ATP6AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.96780441
2Golgi transport vesicle coating (GO:0048200)4.80068695
3COPI coating of Golgi vesicle (GO:0048205)4.80068695
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.63693936
5synaptic vesicle maturation (GO:0016188)4.41169280
6regulation of synaptic vesicle exocytosis (GO:2000300)4.41016462
7glutamate secretion (GO:0014047)4.25532909
8glycosphingolipid catabolic process (GO:0046479)4.11034207
9vocalization behavior (GO:0071625)4.06696028
10neuron cell-cell adhesion (GO:0007158)4.03915244
11protein retention in ER lumen (GO:0006621)3.95620531
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95300937
13synaptic vesicle docking involved in exocytosis (GO:0016081)3.92277879
14locomotory exploration behavior (GO:0035641)3.91724505
15transferrin transport (GO:0033572)3.89978630
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84239636
17regulation of synaptic vesicle transport (GO:1902803)3.83281007
18neuronal action potential propagation (GO:0019227)3.82996135
19amyloid precursor protein catabolic process (GO:0042987)3.82116513
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.81900596
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.81791439
22barbed-end actin filament capping (GO:0051016)3.78461291
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76600276
24glycolipid catabolic process (GO:0019377)3.68562130
25regulation of glutamate receptor signaling pathway (GO:1900449)3.68503728
26protein localization to endosome (GO:0036010)3.68004090
27ferric iron transport (GO:0015682)3.66571595
28trivalent inorganic cation transport (GO:0072512)3.66571595
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.62927979
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.61498791
31neurotransmitter secretion (GO:0007269)3.60382173
32* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.58044736
33* ATP hydrolysis coupled proton transport (GO:0015991)3.58044736
34amino sugar catabolic process (GO:0046348)3.48027924
35protein localization to synapse (GO:0035418)3.44920425
36regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.43941786
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.41365097
38glucose 6-phosphate metabolic process (GO:0051156)3.38996589
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.38499569
40cellular potassium ion homeostasis (GO:0030007)3.37927446
41proline transport (GO:0015824)3.36647927
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34853997
43long-term synaptic potentiation (GO:0060291)3.32379756
44phagosome maturation (GO:0090382)3.29762720
45protein maturation by protein folding (GO:0022417)3.28900638
46neurotransmitter-gated ion channel clustering (GO:0072578)3.25758641
47neuron-neuron synaptic transmission (GO:0007270)3.22846257
48presynaptic membrane assembly (GO:0097105)3.19849720
49oligosaccharide catabolic process (GO:0009313)3.18437114
50ceramide catabolic process (GO:0046514)3.17068010
51mannose metabolic process (GO:0006013)3.15944527
52exploration behavior (GO:0035640)3.15385618
53regulation of synapse structural plasticity (GO:0051823)3.14169838
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13093521
55glutamate receptor signaling pathway (GO:0007215)3.10916564
56synaptic transmission, glutamatergic (GO:0035249)3.07586109
57presynaptic membrane organization (GO:0097090)3.06456608
58gamma-aminobutyric acid transport (GO:0015812)3.03966104
59neurotransmitter transport (GO:0006836)2.99787994
60regulation of neuronal synaptic plasticity (GO:0048168)2.99075909
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96757912
62activation of protein kinase A activity (GO:0034199)2.95030066
63cellular response to thyroid hormone stimulus (GO:0097067)2.94748763
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93732902
65endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.93122752
66regulation of synaptic transmission, glutamatergic (GO:0051966)2.91054624
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90781275
68regulation of excitatory postsynaptic membrane potential (GO:0060079)2.89338466
69postsynaptic membrane organization (GO:0001941)2.84971223
70response to peptidoglycan (GO:0032494)2.84428122
71negative regulation of erythrocyte differentiation (GO:0045647)2.83991091
72neuromuscular process controlling posture (GO:0050884)2.82975471
73regulation of cholesterol storage (GO:0010885)2.80874436
74cerebellar granule cell differentiation (GO:0021707)2.80386078
75neuron recognition (GO:0008038)2.78831944
76regulation of neurotransmitter secretion (GO:0046928)2.78501566
77amyloid precursor protein metabolic process (GO:0042982)2.78435624
78response to thyroid hormone (GO:0097066)2.78191340
79regulation of synaptic plasticity (GO:0048167)2.77216346
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73823525
81regulation of postsynaptic membrane potential (GO:0060078)2.73643255
82regulation of neurotransmitter levels (GO:0001505)2.73246518
83regulation of defense response to virus by virus (GO:0050690)2.71277348
84sphingolipid catabolic process (GO:0030149)2.70886065
85epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70261199
86regulation of vesicle fusion (GO:0031338)2.70086321
87positive regulation of synapse maturation (GO:0090129)2.69345264
88membrane lipid catabolic process (GO:0046466)2.68976708
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68787184
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.68349276
91synaptic vesicle endocytosis (GO:0048488)2.67875548
92positive regulation of membrane potential (GO:0045838)2.67163054
93N-acetylneuraminate metabolic process (GO:0006054)2.66898884
94long-term memory (GO:0007616)2.66737964
95establishment of synaptic vesicle localization (GO:0097480)2.65416019
96synaptic vesicle transport (GO:0048489)2.65416019
97sodium ion export (GO:0071436)2.64428092
98detection of calcium ion (GO:0005513)2.64217457
99cellular copper ion homeostasis (GO:0006878)2.63674378
100regulation of neurotransmitter transport (GO:0051588)2.62899659
101serine transport (GO:0032329)2.62820344
102positive regulation of synaptic transmission (GO:0050806)2.62761106
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.62672683
104regulation of amyloid precursor protein catabolic process (GO:1902991)2.62212865
105vesicle transport along microtubule (GO:0047496)2.61103709
106cerebellar Purkinje cell layer development (GO:0021680)2.60925710
107regulation of leukocyte degranulation (GO:0043300)2.59352347
108negative regulation of cell size (GO:0045792)2.59137854
109response to histamine (GO:0034776)2.58751223
110cell-cell junction maintenance (GO:0045217)2.57961524
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.57129811
112negative regulation of neurotransmitter transport (GO:0051589)2.57057075
113semaphorin-plexin signaling pathway (GO:0071526)2.55038155
114regulation of early endosome to late endosome transport (GO:2000641)2.55001914
115regulation of beta-amyloid formation (GO:1902003)2.52028513
116regulation of regulated secretory pathway (GO:1903305)2.51873675
117pentose-phosphate shunt (GO:0006098)2.50697747
118cerebellar Purkinje cell differentiation (GO:0021702)2.50582902
119apoptotic cell clearance (GO:0043277)2.49578018
120synaptic transmission (GO:0007268)2.49109367
121potassium ion import (GO:0010107)2.47740282
122regulation of synaptic transmission (GO:0050804)2.47624594
123startle response (GO:0001964)2.46331008
124membrane depolarization (GO:0051899)2.46091967
125regulation of voltage-gated calcium channel activity (GO:1901385)2.46032738
126positive regulation of neurotransmitter transport (GO:0051590)2.45980430
127clathrin coat assembly (GO:0048268)2.45951684
128mating behavior (GO:0007617)2.44735900
129ganglioside metabolic process (GO:0001573)2.43612884
130regulation of synaptic transmission, GABAergic (GO:0032228)2.43560781
131layer formation in cerebral cortex (GO:0021819)2.43466211
132protein insertion into membrane (GO:0051205)2.43436554
133mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.43203801
134axonal fasciculation (GO:0007413)2.42565815
135regulation of autophagic vacuole assembly (GO:2000785)2.42407664
136iron ion transport (GO:0006826)2.41840206
137establishment of vesicle localization (GO:0051650)2.41278823
138synapse assembly (GO:0007416)2.41160014
139acidic amino acid transport (GO:0015800)2.40774606
140response to auditory stimulus (GO:0010996)2.40347008
141regulation of cholesterol biosynthetic process (GO:0045540)2.40187488
142glycine transport (GO:0015816)2.39788570
143adult walking behavior (GO:0007628)2.39752548
144* regulation of exocytosis (GO:0017157)2.39401521
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.37153948
146positive regulation of cellular amide metabolic process (GO:0034250)2.37122503
147response to acidic pH (GO:0010447)2.34023198
148positive regulation of leukocyte degranulation (GO:0043302)2.33455469
149activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.33100213
150negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.32535647
151negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31867179
152regulation of superoxide anion generation (GO:0032928)2.30595212
153lipopolysaccharide-mediated signaling pathway (GO:0031663)2.29905151
154L-serine transport (GO:0015825)2.28272427
155glucose catabolic process (GO:0006007)2.25821270
156regulation of mast cell degranulation (GO:0043304)2.25283078
157lysosome organization (GO:0007040)2.24623533
158lytic vacuole organization (GO:0080171)2.24623533
159regulation of ARF protein signal transduction (GO:0032012)2.24393047
160regulation of vacuole organization (GO:0044088)2.23667467
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.23160232
162regulation of T-helper 2 cell differentiation (GO:0045628)2.22741841
163positive regulation of regulated secretory pathway (GO:1903307)2.21732000
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.21639430
165positive regulation of protein dephosphorylation (GO:0035307)2.21584463
166adenosine receptor signaling pathway (GO:0001973)2.21215723
167stress fiber assembly (GO:0043149)2.19116815
168positive regulation of receptor recycling (GO:0001921)2.13991423
169hyaluronan catabolic process (GO:0030214)2.13712316
170membrane protein intracellular domain proteolysis (GO:0031293)2.13650196
171decidualization (GO:0046697)2.12591681
172negative regulation of microtubule polymerization (GO:0031115)2.12527354
173positive regulation of nuclease activity (GO:0032075)2.12276098
174adhesion of symbiont to host (GO:0044406)2.12121879
175vesicle coating (GO:0006901)2.11538821
176pinocytosis (GO:0006907)2.11373125
177neutrophil activation involved in immune response (GO:0002283)2.11226518
178positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.11224712
179alpha-linolenic acid metabolic process (GO:0036109)2.11008430
180amino acid import (GO:0043090)2.10679750
181glial cell migration (GO:0008347)2.10590492
182oligosaccharide metabolic process (GO:0009311)2.09741148
183intracellular estrogen receptor signaling pathway (GO:0030520)2.09199929
184G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.08290044
185virion assembly (GO:0019068)2.07821299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.16379122
2GBX2_23144817_ChIP-Seq_PC3_Human3.87542869
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.19423181
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05717297
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98512250
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97542591
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.91374288
8LXR_22292898_ChIP-Seq_THP-1_Human2.89406404
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58033333
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55154623
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47998919
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46379670
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44326668
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42826151
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36722468
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36722468
17REST_21632747_ChIP-Seq_MESCs_Mouse2.32452885
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31124631
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.26241748
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21751165
21VDR_21846776_ChIP-Seq_THP-1_Human2.20826098
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.20116682
23RACK7_27058665_Chip-Seq_MCF-7_Human2.15382036
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12677246
25DROSHA_22980978_ChIP-Seq_HELA_Human2.11208063
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10235707
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09868359
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.09429964
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.09324431
30ZNF263_19887448_ChIP-Seq_K562_Human2.08145378
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.06613286
32TP63_17297297_ChIP-ChIP_HaCaT_Human2.06207478
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.04520351
34TAF15_26573619_Chip-Seq_HEK293_Human1.97621593
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97536599
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.90112462
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88811415
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.87039403
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82060956
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79567918
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78535843
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.77779582
43KDM2B_26808549_Chip-Seq_K562_Human1.75224477
44KDM2B_26808549_Chip-Seq_DND41_Human1.73493938
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71951551
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.71315096
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69064613
48AR_21572438_ChIP-Seq_LNCaP_Human1.68287764
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67762597
50SMAD4_21799915_ChIP-Seq_A2780_Human1.66734948
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66231680
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65115634
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64331626
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.63011754
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.62796508
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60835251
57P68_20966046_ChIP-Seq_HELA_Human1.59221301
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58962173
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.58814351
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54834922
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53935238
62TCF7_22412390_ChIP-Seq_EML_Mouse1.52492245
63SMC4_20622854_ChIP-Seq_HELA_Human1.51544321
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51372913
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49693373
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47772958
67CLOCK_20551151_ChIP-Seq_293T_Human1.46787212
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45824742
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45761829
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.44364174
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.42881373
72P300_19829295_ChIP-Seq_ESCs_Human1.42681730
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.42345351
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42054640
75VDR_24763502_ChIP-Seq_THP-1_Human1.41869295
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41196717
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38484677
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37148314
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.34421497
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33805273
81ZNF274_21170338_ChIP-Seq_K562_Hela1.32476555
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.32352096
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32301253
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32183483
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32181621
86BCL6_27268052_Chip-Seq_Bcells_Human1.32180934
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32155343
88AR_25329375_ChIP-Seq_VCAP_Human1.30394207
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30312395
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29641453
91BCOR_27268052_Chip-Seq_Bcells_Human1.28470362
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.28039844
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27656260
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27639540
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27568541
96* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26900063
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26541585
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26251809
99CREB1_26743006_Chip-Seq_LNCaP_Human1.24159994
100MYC_22102868_ChIP-Seq_BL_Human1.23296159
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23021348
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.22845650
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21637339
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21559288
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21114224
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20778361
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.20097553
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19963821
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19963821
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19202328
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16316695
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15715533
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15692203
114ER_23166858_ChIP-Seq_MCF-7_Human1.15553350
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15286325
116SPI1_23127762_ChIP-Seq_K562_Human1.15255439
117TET1_21490601_ChIP-Seq_MESCs_Mouse1.15017311
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.13935087
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13560410
120DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12698158
121STAT3_23295773_ChIP-Seq_U87_Human1.11920805
122IGF1R_20145208_ChIP-Seq_DFB_Human1.11043034
123HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10994326
124* ERG_21242973_ChIP-ChIP_JURKAT_Human1.10735330
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09903689
126AHR_22903824_ChIP-Seq_MCF-7_Human1.09612608
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09521574
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09078360
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09066366
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09007161
131RUNX1_27514584_Chip-Seq_MCF-7_Human1.08986860
132CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08950092
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08297464
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07492293
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06480845
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.06012720
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05979663
138EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05792580
139SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05525756
140GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05445712
141PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05371490
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04959897
143ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04937531
144CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04652418
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04402613
146CTCF_27219007_Chip-Seq_Bcells_Human1.04199559
147RXR_22108803_ChIP-Seq_LS180_Human1.03874543
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03039316
149P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02883967
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02852684
151BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02743443
152PRDM14_20953172_ChIP-Seq_ESCs_Human1.02612819
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02534321
154TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02499454
155CTCF_26484167_Chip-Seq_Bcells_Mouse1.02469988
156TP53_22127205_ChIP-Seq_IMR90_Human1.02362130
157WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01959715
158TP53_18474530_ChIP-ChIP_U2OS_Human1.01506654
159IRF8_21731497_ChIP-ChIP_J774_Mouse1.01152131
160AR_19668381_ChIP-Seq_PC3_Human1.00967568
161P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00450266
162ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00387564
163SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00057888
164STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99727629
165SA1_27219007_Chip-Seq_Bcells_Human0.99363900
166GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99280907
167TCF4_23295773_ChIP-Seq_U87_Human0.97437302
168RUNX2_22187159_ChIP-Seq_PCA_Human0.94557697
169SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94500903
170VDR_22108803_ChIP-Seq_LS180_Human0.93982604
171EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92621931
172UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92002408
173CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90548123
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90283472
175MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89621157
176SMAD3_21741376_ChIP-Seq_ESCs_Human0.89465527
177YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88998387
178RING1B_27294783_Chip-Seq_ESCs_Mouse0.88963206
179TRIM28_21343339_ChIP-Seq_HEK293_Human0.87960871
180CBX2_27304074_Chip-Seq_ESCs_Mouse0.87910988
181JUN_21703547_ChIP-Seq_K562_Human0.87233514
182NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86340124
183EP300_21415370_ChIP-Seq_HL-1_Mouse0.86204969
184* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84386430
185FLI1_21867929_ChIP-Seq_TH2_Mouse0.81881367
186BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81801238
187SMAD4_21741376_ChIP-Seq_HESCs_Human0.80700311
188WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79841213
189RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79609892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98215621
2MP0003880_abnormal_central_pattern4.10929823
3MP0009840_abnormal_foam_cell4.02295255
4MP0003635_abnormal_synaptic_transmissio3.54509821
5MP0003191_abnormal_cellular_cholesterol3.50694030
6MP0002064_seizures3.18078967
7MP0009046_muscle_twitch3.09668699
8MP0004270_analgesia3.08386586
9MP0009745_abnormal_behavioral_response2.98398762
10MP0001968_abnormal_touch/_nociception2.79038062
11MP0002063_abnormal_learning/memory/cond2.78721109
12MP0009780_abnormal_chondrocyte_physiolo2.71827503
13MP0005451_abnormal_body_composition2.61383217
14MP0002572_abnormal_emotion/affect_behav2.51903054
15MP0002736_abnormal_nociception_after2.49189234
16MP0002272_abnormal_nervous_system2.43981606
17MP0002734_abnormal_mechanical_nocicepti2.42364017
18MP0003329_amyloid_beta_deposits2.39750988
19MP0003436_decreased_susceptibility_to2.34341428
20MP0002735_abnormal_chemical_nociception2.32825292
21MP0001501_abnormal_sleep_pattern2.28228336
22MP0003183_abnormal_peptide_metabolism2.17126319
23MP0009278_abnormal_bone_marrow2.12761697
24MP0006082_CNS_inflammation2.04864482
25MP0000013_abnormal_adipose_tissue2.02961089
26MP0002909_abnormal_adrenal_gland2.02083284
27MP0001486_abnormal_startle_reflex2.01714305
28MP0001970_abnormal_pain_threshold2.01102651
29MP0002733_abnormal_thermal_nociception2.00876658
30MP0001440_abnormal_grooming_behavior1.93122378
31MP0002822_catalepsy1.91897291
32MP0005058_abnormal_lysosome_morphology1.87125232
33MP0000343_altered_response_to1.86643184
34MP0002067_abnormal_sensory_capabilities1.84743151
35MP0010386_abnormal_urinary_bladder1.83994349
36MP0004858_abnormal_nervous_system1.80915258
37MP0003172_abnormal_lysosome_physiology1.79830467
38MP0002837_dystrophic_cardiac_calcinosis1.77542875
39MP0003705_abnormal_hypodermis_morpholog1.71533179
40MP0003879_abnormal_hair_cell1.67076408
41MP0008569_lethality_at_weaning1.63656637
42MP0000604_amyloidosis1.62799018
43MP0005646_abnormal_pituitary_gland1.61744857
44MP0002419_abnormal_innate_immunity1.60273053
45MP0005423_abnormal_somatic_nervous1.57176592
46MP0002877_abnormal_melanocyte_morpholog1.55169395
47MP0001849_ear_inflammation1.52323720
48MP0004043_abnormal_pH_regulation1.50122684
49MP0005167_abnormal_blood-brain_barrier1.49788825
50MP0000920_abnormal_myelination1.49233828
51MP0003300_gastrointestinal_ulcer1.46680392
52MP0004811_abnormal_neuron_physiology1.46627263
53MP0005386_behavior/neurological_phenoty1.46153238
54MP0004924_abnormal_behavior1.46153238
55MP0001533_abnormal_skeleton_physiology1.45593971
56MP0001529_abnormal_vocalization1.45296777
57MP0003690_abnormal_glial_cell1.44774697
58MP0002184_abnormal_innervation1.43220370
59MP0001984_abnormal_olfaction1.42963657
60MP0002148_abnormal_hypersensitivity_rea1.41960785
61MP0003633_abnormal_nervous_system1.41929608
62MP0001905_abnormal_dopamine_level1.39553392
63MP0006276_abnormal_autonomic_nervous1.36853325
64MP0003634_abnormal_glial_cell1.36315433
65MP0005025_abnormal_response_to1.34332469
66MP0003724_increased_susceptibility_to1.33811182
67MP0002557_abnormal_social/conspecific_i1.32728532
68MP0005257_abnormal_intraocular_pressure1.29792393
69MP0002066_abnormal_motor_capabilities/c1.27816458
70MP0002090_abnormal_vision1.26575881
71MP0004142_abnormal_muscle_tone1.26516829
72MP0000858_altered_metastatic_potential1.26377556
73MP0005464_abnormal_platelet_physiology1.26339979
74MP0002998_abnormal_bone_remodeling1.25465235
75MP0003453_abnormal_keratinocyte_physiol1.25428150
76MP0000955_abnormal_spinal_cord1.23409080
77MP0003122_maternal_imprinting1.21518981
78MP0000778_abnormal_nervous_system1.19992961
79MP0002882_abnormal_neuron_morphology1.18053900
80MP0003631_nervous_system_phenotype1.16963656
81MP0004947_skin_inflammation1.16050294
82MP0005645_abnormal_hypothalamus_physiol1.15677985
83MP0004885_abnormal_endolymph1.12629887
84MP0002229_neurodegeneration1.11858183
85MP0003566_abnormal_cell_adhesion1.09710417
86MP0005000_abnormal_immune_tolerance1.09299840
87MP0001502_abnormal_circadian_rhythm1.08714682
88MP0009785_altered_susceptibility_to1.07609529
89MP0003075_altered_response_to1.05703020
90MP0002139_abnormal_hepatobiliary_system1.05355740
91MP0004782_abnormal_surfactant_physiolog1.04918805
92MP0005166_decreased_susceptibility_to1.04089317
93MP0005165_increased_susceptibility_to1.03987074
94MP0003279_aneurysm1.03556313
95MP0000751_myopathy1.03427304
96MP0001545_abnormal_hematopoietic_system1.03297943
97MP0005397_hematopoietic_system_phenotyp1.03297943
98MP0008438_abnormal_cutaneous_collagen1.03266258
99MP0002653_abnormal_ependyma_morphology1.00145104
100MP0003195_calcinosis0.99619161
101MP0002876_abnormal_thyroid_physiology0.98593254
102MP0003787_abnormal_imprinting0.94671181
103MP0005171_absent_coat_pigmentation0.94014823
104MP0003632_abnormal_nervous_system0.93110375
105MP0000678_abnormal_parathyroid_gland0.93009051
106MP0010234_abnormal_vibrissa_follicle0.92046075
107MP0005409_darkened_coat_color0.90517673
108MP0005535_abnormal_body_temperature0.84570273
109MP0005551_abnormal_eye_electrophysiolog0.84380599
110MP0001299_abnormal_eye_distance/0.83515020
111MP0004742_abnormal_vestibular_system0.83443624
112MP0002069_abnormal_eating/drinking_beha0.83345643
113MP0008874_decreased_physiological_sensi0.83095142
114MP0003656_abnormal_erythrocyte_physiolo0.81610905
115MP0001542_abnormal_bone_strength0.80916214
116MP0008469_abnormal_protein_level0.80106308
117MP0001845_abnormal_inflammatory_respons0.79290393
118MP0005310_abnormal_salivary_gland0.77663278
119MP0002896_abnormal_bone_mineralization0.77144358
120MP0001765_abnormal_ion_homeostasis0.76746942
121MP0001853_heart_inflammation0.76091327
122MP0002796_impaired_skin_barrier0.75016334
123MP0001664_abnormal_digestion0.74867192
124MP0003303_peritoneal_inflammation0.74370173
125MP0004085_abnormal_heartbeat0.73654215
126MP0005387_immune_system_phenotype0.73289032
127MP0001790_abnormal_immune_system0.73289032
128MP0004484_altered_response_of0.73166890
129MP0001963_abnormal_hearing_physiology0.71919995
130MP0005390_skeleton_phenotype0.71837880
131MP0004233_abnormal_muscle_weight0.71703587
132MP0003123_paternal_imprinting0.71662805
133MP0002452_abnormal_antigen_presenting0.71125570
134MP0002152_abnormal_brain_morphology0.71056236
135MP0004130_abnormal_muscle_cell0.70694873
136MP0009764_decreased_sensitivity_to0.70380004
137MP0003091_abnormal_cell_migration0.70249132
138MP0002089_abnormal_postnatal_growth/wei0.69587216
139MP0005671_abnormal_response_to0.69084489
140MP0003795_abnormal_bone_structure0.68110650
141MP0005365_abnormal_bile_salt0.68036258
142MP0008004_abnormal_stomach_pH0.67600673
143MP0009333_abnormal_splenocyte_physiolog0.67460046
144MP0004264_abnormal_extraembryonic_tissu0.67051823
145MP0002723_abnormal_immune_serum0.66876364
146MP0001727_abnormal_embryo_implantation0.65937153
147MP0005623_abnormal_meninges_morphology0.65856563
148MP0000747_muscle_weakness0.64650204
149MP0001177_atelectasis0.63707899
150MP0010155_abnormal_intestine_physiology0.63027427
151MP0003283_abnormal_digestive_organ0.62660355
152MP0003045_fibrosis0.62436569
153MP0000681_abnormal_thyroid_gland0.61513679
154MP0004145_abnormal_muscle_electrophysio0.61130993
155MP0004036_abnormal_muscle_relaxation0.60978078
156MP0004215_abnormal_myocardial_fiber0.60692238
157MP0000003_abnormal_adipose_tissue0.60449588
158MP0001986_abnormal_taste_sensitivity0.59325546
159MP0000230_abnormal_systemic_arterial0.59308940
160MP0004510_myositis0.59305629
161MP0001188_hyperpigmentation0.57678229
162MP0008260_abnormal_autophagy0.55233558

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.14117985
2Atonic seizures (HP:0010819)4.72006103
3Visual hallucinations (HP:0002367)4.53718948
4Focal seizures (HP:0007359)4.38197746
5Myokymia (HP:0002411)4.34281596
6Epileptic encephalopathy (HP:0200134)4.22726068
7Absence seizures (HP:0002121)3.75236991
8Supranuclear gaze palsy (HP:0000605)3.74303124
9Increased cerebral lipofuscin (HP:0011813)3.73247342
10J-shaped sella turcica (HP:0002680)3.71804723
11Neurofibrillary tangles (HP:0002185)3.67717215
12Pheochromocytoma (HP:0002666)3.60574803
13Dialeptic seizures (HP:0011146)3.55790976
14Cerebral inclusion bodies (HP:0100314)3.39574407
15Generalized tonic-clonic seizures (HP:0002069)3.33812898
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.32091690
17Diminished motivation (HP:0000745)3.26866352
18Febrile seizures (HP:0002373)3.24691580
19Neuroendocrine neoplasm (HP:0100634)3.23555463
20Vertebral compression fractures (HP:0002953)3.15771694
21Abnormal eating behavior (HP:0100738)3.12090141
22Abnormality of macrophages (HP:0004311)3.04796485
23Systemic lupus erythematosus (HP:0002725)2.98186265
24Axonal loss (HP:0003447)2.97957972
25Dysostosis multiplex (HP:0000943)2.94997847
26Polyphagia (HP:0002591)2.94794881
27Mutism (HP:0002300)2.94689449
28Progressive cerebellar ataxia (HP:0002073)2.94256026
29Hyperventilation (HP:0002883)2.93856323
30Action tremor (HP:0002345)2.92816049
31Nuclear cataract (HP:0100018)2.91997032
32Diplopia (HP:0000651)2.86458726
33Abnormality of binocular vision (HP:0011514)2.86458726
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77846255
35Hand muscle atrophy (HP:0009130)2.77628571
36Upper limb amyotrophy (HP:0009129)2.76284769
37Distal upper limb amyotrophy (HP:0007149)2.76284769
38Neuronal loss in central nervous system (HP:0002529)2.76217751
39Depression (HP:0000716)2.71260053
40Abnormality of glycolipid metabolism (HP:0010969)2.70644212
41Abnormality of liposaccharide metabolism (HP:0010968)2.70644212
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.70644212
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.61406400
44Ankle clonus (HP:0011448)2.60694046
45Truncal ataxia (HP:0002078)2.58008779
46Anxiety (HP:0000739)2.55933029
47Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55010296
48Progressive neurologic deterioration (HP:0002344)2.53987707
49Failure to thrive in infancy (HP:0001531)2.51693798
50Progressive inability to walk (HP:0002505)2.46588127
51Epileptiform EEG discharges (HP:0011182)2.43382867
52Dysmetria (HP:0001310)2.40918296
53Cholecystitis (HP:0001082)2.38956176
54Abnormal gallbladder physiology (HP:0012438)2.38956176
55Purpura (HP:0000979)2.38386092
56Prolonged neonatal jaundice (HP:0006579)2.37335286
57Hyperparathyroidism (HP:0000843)2.36279068
58Agitation (HP:0000713)2.36101188
59Broad-based gait (HP:0002136)2.35490703
60Dysdiadochokinesis (HP:0002075)2.33589573
61Akinesia (HP:0002304)2.31702012
62Interstitial pulmonary disease (HP:0006530)2.31375374
63Insidious onset (HP:0003587)2.30704289
64Termporal pattern (HP:0011008)2.30704289
65Amyloidosis (HP:0011034)2.28979263
66EEG with generalized epileptiform discharges (HP:0011198)2.28341521
67Poor eye contact (HP:0000817)2.27769947
68Resting tremor (HP:0002322)2.27274810
69Dementia (HP:0000726)2.26611600
70Abnormal hair whorl (HP:0010721)2.26304297
71Disinhibition (HP:0000734)2.21693651
72Abnormal social behavior (HP:0012433)2.19847888
73Impaired social interactions (HP:0000735)2.19847888
74Urinary glycosaminoglycan excretion (HP:0003541)2.19204344
75Mucopolysacchariduria (HP:0008155)2.19204344
76Eczematoid dermatitis (HP:0000976)2.18750644
77Cerebral aneurysm (HP:0004944)2.18625020
78Papilledema (HP:0001085)2.16859202
79Postural instability (HP:0002172)2.15817540
80Hypsarrhythmia (HP:0002521)2.15519359
81Spastic gait (HP:0002064)2.13906066
82Limb dystonia (HP:0002451)2.13166071
83Torticollis (HP:0000473)2.09753924
84Generalized myoclonic seizures (HP:0002123)2.09207529
85Hyperacusis (HP:0010780)2.09178390
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09123239
87Abnormality of polysaccharide metabolism (HP:0011012)2.09123239
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09123239
89Recurrent abscess formation (HP:0002722)2.08492007
90Psychosis (HP:0000709)2.08255900
91Intention tremor (HP:0002080)2.08119871
92Oligomenorrhea (HP:0000876)2.07504386
93Gaze-evoked nystagmus (HP:0000640)2.06195005
94Deformed sella turcica (HP:0002681)2.06094589
95Distal lower limb muscle weakness (HP:0009053)2.05713739
96Impaired vibration sensation in the lower limbs (HP:0002166)2.05654198
97Abnormality of the corticospinal tract (HP:0002492)2.05261407
98Amblyopia (HP:0000646)2.03732424
99Postural tremor (HP:0002174)2.02493713
100Cardiomegaly (HP:0001640)2.01763607
101Hepatosplenomegaly (HP:0001433)2.01666339
102Scanning speech (HP:0002168)2.00956410
103Excessive salivation (HP:0003781)2.00272060
104Drooling (HP:0002307)2.00272060
105Clumsiness (HP:0002312)1.99501630
106Achilles tendon contracture (HP:0001771)1.99467984
107Rapidly progressive (HP:0003678)1.98709103
108Hypokinesia (HP:0002375)1.98543933
109Retinal atrophy (HP:0001105)1.96677314
110Abnormality of the periventricular white matter (HP:0002518)1.96486129
111Cervical subluxation (HP:0003308)1.95688137
112Hypoventilation (HP:0002791)1.94894234
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.94837717
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94837717
115Bradykinesia (HP:0002067)1.93717444
116Growth hormone excess (HP:0000845)1.92454152
117Pathologic fracture (HP:0002756)1.92038485
118Upper motor neuron abnormality (HP:0002127)1.92012180
119Focal dystonia (HP:0004373)1.91838859
120Gait imbalance (HP:0002141)1.91501207
121Asymmetric septal hypertrophy (HP:0001670)1.91439993
122Personality changes (HP:0000751)1.91403780
123Rigidity (HP:0002063)1.91074636
124Recurrent bacterial skin infections (HP:0005406)1.90261229
125Urinary bladder sphincter dysfunction (HP:0002839)1.89510038
126Neoplasm of the peripheral nervous system (HP:0100007)1.88949002
127Increased serum ferritin (HP:0003281)1.88362850
128Retinal dysplasia (HP:0007973)1.85869708
129Vacuolated lymphocytes (HP:0001922)1.84146192
130Thin bony cortex (HP:0002753)1.83362116
131Hypercortisolism (HP:0001578)1.82735478
132Inability to walk (HP:0002540)1.81937322
133Glomerulonephritis (HP:0000099)1.81926764
134Poor suck (HP:0002033)1.81861096
135Gait ataxia (HP:0002066)1.81109255
136Ragged-red muscle fibers (HP:0003200)1.80674061
137Loss of speech (HP:0002371)1.80265704
138Bone pain (HP:0002653)1.79872418
139Abnormality of the Achilles tendon (HP:0005109)1.79766201
140Craniofacial dystonia (HP:0012179)1.78773745
141Insomnia (HP:0100785)1.78614488
142Blue irides (HP:0000635)1.78206724
143Fetal akinesia sequence (HP:0001989)1.77996391
144Apathy (HP:0000741)1.77180933
145Increased circulating renin level (HP:0000848)1.76637513
146Peripheral hypomyelination (HP:0007182)1.76394730
147Lower limb muscle weakness (HP:0007340)1.76156121
148Urinary urgency (HP:0000012)1.73697460
149Long toe (HP:0010511)1.70414062
150Obstructive lung disease (HP:0006536)1.69983975
151Chronic obstructive pulmonary disease (HP:0006510)1.69983975
152Thoracic kyphosis (HP:0002942)1.68576806
153Abnormal neuron morphology (HP:0012757)1.67444225
154Abnormality of the motor neurons (HP:0002450)1.67444225
155Petechiae (HP:0000967)1.65995357
156Abnormality of the nasal mucosa (HP:0000433)1.65913610
157Reticulocytosis (HP:0001923)1.65576327
158Premature rupture of membranes (HP:0001788)1.64803931
159Joint stiffness (HP:0001387)1.64015017
160Urinary incontinence (HP:0000020)1.63296137
161Broad face (HP:0000283)1.62918438
162Hypertensive crisis (HP:0100735)1.60472305
163Slow saccadic eye movements (HP:0000514)1.60123570
164Stridor (HP:0010307)1.59192660
165Athetosis (HP:0002305)1.57980884
166Distal lower limb amyotrophy (HP:0008944)1.57587456
167Mitral stenosis (HP:0001718)1.57104135
168Abdominal distention (HP:0003270)1.56356415
169Fasciculations (HP:0002380)1.56348768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.69780336
2NTRK33.57387100
3CASK3.45103565
4TESK13.38603640
5MAP3K93.04560082
6TESK23.04484587
7IRAK32.94687661
8ERN12.92496119
9MAP3K122.71234932
10NME22.67489211
11EPHA42.67424204
12MAP3K42.49952150
13MAP2K72.28850481
14MAP3K112.25662953
15DAPK22.23440388
16NTRK12.16991814
17CDK192.16247457
18SIK12.16069540
19PLK22.13233650
20OXSR12.11139077
21MINK12.09960541
22RIPK42.04031704
23MARK11.97463290
24PIM21.91235469
25CAMKK21.83990222
26ICK1.82668270
27SMG11.76997456
28RIPK11.76151962
29TAOK21.71800015
30PAK61.71641084
31KSR21.71604271
32PRPF4B1.66869764
33GRK51.61808321
34PKN21.61343282
35MAP2K41.60640393
36TAOK11.56881643
37ARAF1.54061108
38DAPK11.51552694
39MAP3K21.45568067
40EPHA21.44335032
41TBK11.43408346
42MAP3K31.41298081
43CDK51.41255118
44CAMKK11.35300923
45NTRK21.34229545
46FES1.34065590
47BCKDK1.26991553
48PRKCG1.19923970
49PRKCH1.18840864
50SGK4941.16571976
51SGK2231.16571976
52CAMK2A1.10494073
53CAMK2B1.10226872
54PTK2B1.04261222
55EPHB11.03336734
56PAK41.01131810
57STK391.00714569
58PRKCE0.99230776
59PHKG10.97139459
60PHKG20.97139459
61MAPKAPK30.96477496
62MAP3K130.96022722
63MAP2K30.94800634
64PAK30.94327121
65WNK40.94085674
66PRKD30.93855618
67AKT30.93517287
68BLK0.92699185
69UHMK10.91758108
70FGFR40.90163529
71MARK20.89999523
72CDK140.89646246
73TYK20.87406304
74CCNB10.84773412
75KSR10.83401223
76GRK70.83290323
77CDK180.83154373
78FGR0.83034486
79CAMK2D0.82548003
80CDC42BPA0.82200905
81LIMK10.81108066
82CDK150.79873126
83MATK0.79739643
84ABL20.79246079
85MAP3K10.79137514
86RET0.77502025
87EEF2K0.77112388
88PRKD20.76226800
89PDK20.75524490
90INSRR0.75412350
91MAPK130.74925350
92FER0.74680345
93GRK60.74493415
94SCYL20.73670638
95IRAK40.73126170
96MAPKAPK50.72967613
97TNIK0.72953284
98PDPK10.70814308
99IRAK20.70238166
100WNK30.69900089
101PDK30.69564883
102PDK40.69564883
103SGK20.68865481
104CSNK1G20.68318399
105MAP2K10.66033175
106WNK10.65414701
107MAP3K140.64758462
108CDK11A0.64268674
109CAMK2G0.64019855
110DYRK1B0.63909268
111PTK60.63162268
112TGFBR20.61884370
113DAPK30.61741926
114ZAP700.61689066
115BCR0.61528800
116SIK30.61501905
117FYN0.59745359
118PDK10.58546960
119SGK30.58308806
120MAP2K20.58031149
121ROCK20.57178894
122BMPR20.57013702
123TSSK60.56025917
124TTN0.55840613
125CSK0.55554245
126BMPR1B0.55276051
127TNK20.55038925
128SIK20.54599468
129CSF1R0.54142820
130ADRBK10.53757821
131NME10.53622472
132EPHA30.52146064
133SGK10.51200177
134CAMK1D0.50470152
135CAMK10.50406395
136PDGFRA0.49062945
137CSNK1G30.48450151
138PTK20.47698698
139MYLK0.47527928
140LRRK20.47003923
141RPS6KC10.46921034
142RPS6KL10.46921034
143ADRBK20.46825434
144MAPK120.46693125
145STK380.46674229
146PRKG20.46290840
147MAP3K60.43732500
148KDR0.43229264
149PRKD10.43140648
150RPS6KA20.42888552
151TYRO30.42580604
152STK110.42502136
153HIPK20.42228187
154LATS20.42190297
155PKN10.42055747
156DYRK1A0.41204058
157MOS0.39214174
158DDR20.35817383
159CAMK1G0.35245748
160LMTK20.35206546

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.78217663
2Collecting duct acid secretion_Homo sapiens_hsa049663.34558151
3Nicotine addiction_Homo sapiens_hsa050332.90788899
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.83623606
5GABAergic synapse_Homo sapiens_hsa047272.33543731
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28101767
7* Vibrio cholerae infection_Homo sapiens_hsa051102.25048814
8Olfactory transduction_Homo sapiens_hsa047402.09998084
9Circadian entrainment_Homo sapiens_hsa047132.08513586
10Morphine addiction_Homo sapiens_hsa050322.07614637
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91752052
12Long-term potentiation_Homo sapiens_hsa047201.87581989
13Glutamatergic synapse_Homo sapiens_hsa047241.83853839
14Insulin secretion_Homo sapiens_hsa049111.83435582
15Amphetamine addiction_Homo sapiens_hsa050311.82491675
16Dopaminergic synapse_Homo sapiens_hsa047281.77290127
17Salivary secretion_Homo sapiens_hsa049701.68830986
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64810445
19Serotonergic synapse_Homo sapiens_hsa047261.53130296
20* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51402401
21* Lysosome_Homo sapiens_hsa041421.51023224
22Taste transduction_Homo sapiens_hsa047421.50433144
23Gastric acid secretion_Homo sapiens_hsa049711.48811496
24Cholinergic synapse_Homo sapiens_hsa047251.48792649
25Long-term depression_Homo sapiens_hsa047301.45314358
26Galactose metabolism_Homo sapiens_hsa000521.44945536
27Renin secretion_Homo sapiens_hsa049241.44209799
28Fructose and mannose metabolism_Homo sapiens_hsa000511.41975860
29Cocaine addiction_Homo sapiens_hsa050301.41890503
30Osteoclast differentiation_Homo sapiens_hsa043801.40626722
31* Rheumatoid arthritis_Homo sapiens_hsa053231.32966701
32* Phagosome_Homo sapiens_hsa041451.31919584
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31658091
34Pentose phosphate pathway_Homo sapiens_hsa000301.30491773
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27274695
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27005378
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26980578
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20449837
39Bladder cancer_Homo sapiens_hsa052191.20089841
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19968250
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17199927
42Calcium signaling pathway_Homo sapiens_hsa040201.15895402
43Oxytocin signaling pathway_Homo sapiens_hsa049211.14061162
44Pertussis_Homo sapiens_hsa051331.11759058
45* Oxidative phosphorylation_Homo sapiens_hsa001901.11429274
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08341856
47Acute myeloid leukemia_Homo sapiens_hsa052211.07159420
48Leishmaniasis_Homo sapiens_hsa051401.06300855
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04043340
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00239784
51Type II diabetes mellitus_Homo sapiens_hsa049301.00067032
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99473205
53Shigellosis_Homo sapiens_hsa051310.98955879
54Gap junction_Homo sapiens_hsa045400.98578857
55Staphylococcus aureus infection_Homo sapiens_hsa051500.96592747
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95082786
57GnRH signaling pathway_Homo sapiens_hsa049120.94926513
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93054272
59cAMP signaling pathway_Homo sapiens_hsa040240.91384749
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90253930
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87786227
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.86772331
63Estrogen signaling pathway_Homo sapiens_hsa049150.86673791
64Notch signaling pathway_Homo sapiens_hsa043300.85961362
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84226734
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83800799
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83311353
68Type I diabetes mellitus_Homo sapiens_hsa049400.83098413
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82421064
70Amoebiasis_Homo sapiens_hsa051460.80956092
71Alzheimers disease_Homo sapiens_hsa050100.80795643
72Hepatitis C_Homo sapiens_hsa051600.80794549
73Axon guidance_Homo sapiens_hsa043600.77657585
74Legionellosis_Homo sapiens_hsa051340.77593795
75Pancreatic secretion_Homo sapiens_hsa049720.76925088
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76360137
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.74970362
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74823012
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.74541778
80Glioma_Homo sapiens_hsa052140.73835231
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73177851
82Thyroid hormone synthesis_Homo sapiens_hsa049180.72823211
83Other glycan degradation_Homo sapiens_hsa005110.71350407
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70673046
85Toxoplasmosis_Homo sapiens_hsa051450.70293836
86Cardiac muscle contraction_Homo sapiens_hsa042600.68590139
87TNF signaling pathway_Homo sapiens_hsa046680.66471263
88Non-small cell lung cancer_Homo sapiens_hsa052230.66366230
89Endocytosis_Homo sapiens_hsa041440.65881817
90mTOR signaling pathway_Homo sapiens_hsa041500.63940228
91Chronic myeloid leukemia_Homo sapiens_hsa052200.63481761
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63232395
93Phenylalanine metabolism_Homo sapiens_hsa003600.63050238
94B cell receptor signaling pathway_Homo sapiens_hsa046620.62700200
95Insulin signaling pathway_Homo sapiens_hsa049100.61918647
96Malaria_Homo sapiens_hsa051440.61688627
97ErbB signaling pathway_Homo sapiens_hsa040120.61473517
98Dilated cardiomyopathy_Homo sapiens_hsa054140.61273637
99AMPK signaling pathway_Homo sapiens_hsa041520.60728473
100Endometrial cancer_Homo sapiens_hsa052130.60046752
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58805669
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.58672881
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.58364957
104Biosynthesis of amino acids_Homo sapiens_hsa012300.57572859
105Parkinsons disease_Homo sapiens_hsa050120.57482928
106Carbon metabolism_Homo sapiens_hsa012000.56014595
107Phototransduction_Homo sapiens_hsa047440.55958606
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.54986942
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.54873777
110Pancreatic cancer_Homo sapiens_hsa052120.54745339
111HIF-1 signaling pathway_Homo sapiens_hsa040660.53705837
112Prion diseases_Homo sapiens_hsa050200.53504169
113Sphingolipid metabolism_Homo sapiens_hsa006000.52302266
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52223729
115Melanogenesis_Homo sapiens_hsa049160.51885848
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51318241
117Renal cell carcinoma_Homo sapiens_hsa052110.51263327
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50740612
119Apoptosis_Homo sapiens_hsa042100.50417914
120Prolactin signaling pathway_Homo sapiens_hsa049170.49296155
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48755302
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.48055837
123Ras signaling pathway_Homo sapiens_hsa040140.46805686
124MAPK signaling pathway_Homo sapiens_hsa040100.46332496
125* Tuberculosis_Homo sapiens_hsa051520.45114760
126PPAR signaling pathway_Homo sapiens_hsa033200.43429208
127N-Glycan biosynthesis_Homo sapiens_hsa005100.41628195
128Influenza A_Homo sapiens_hsa051640.41004315
129Fatty acid elongation_Homo sapiens_hsa000620.39943553
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39244186
131Sulfur relay system_Homo sapiens_hsa041220.39228604
132Steroid biosynthesis_Homo sapiens_hsa001000.39079352
133Regulation of autophagy_Homo sapiens_hsa041400.38342050
134Inositol phosphate metabolism_Homo sapiens_hsa005620.38298697
135Chemokine signaling pathway_Homo sapiens_hsa040620.37656152
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35886727
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35526802
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35458573
139Rap1 signaling pathway_Homo sapiens_hsa040150.35401021
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35019175
141Choline metabolism in cancer_Homo sapiens_hsa052310.34673531
142Dorso-ventral axis formation_Homo sapiens_hsa043200.33926774
143VEGF signaling pathway_Homo sapiens_hsa043700.33274856
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32631821
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31944082
146Mineral absorption_Homo sapiens_hsa049780.31572152
147Glucagon signaling pathway_Homo sapiens_hsa049220.29634158
148Salmonella infection_Homo sapiens_hsa051320.29603648
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29314278
150Sulfur metabolism_Homo sapiens_hsa009200.27425160

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