ATP6AP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)5.77863288
2cell wall macromolecule catabolic process (GO:0016998)5.68998704
3cell wall macromolecule metabolic process (GO:0044036)5.68998704
4cilium or flagellum-dependent cell motility (GO:0001539)5.67915165
5fusion of sperm to egg plasma membrane (GO:0007342)5.58183875
6behavioral response to nicotine (GO:0035095)5.45166403
7sperm motility (GO:0030317)5.26791998
8calcium ion-dependent exocytosis (GO:0017156)4.96464816
9synaptic vesicle exocytosis (GO:0016079)4.90868217
10protein localization to synapse (GO:0035418)4.89631250
11epithelial cilium movement (GO:0003351)4.83973988
12motile cilium assembly (GO:0044458)4.78534737
13acrosome assembly (GO:0001675)4.77053601
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.73613952
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.67413101
16plasma membrane fusion (GO:0045026)4.67408192
17neuron cell-cell adhesion (GO:0007158)4.64660783
18axonemal dynein complex assembly (GO:0070286)4.64180848
19vocalization behavior (GO:0071625)4.62052576
20multicellular organism reproduction (GO:0032504)4.58892085
21neuronal action potential propagation (GO:0019227)4.57107059
22L-fucose catabolic process (GO:0042355)4.46229023
23fucose catabolic process (GO:0019317)4.46229023
24L-fucose metabolic process (GO:0042354)4.46229023
25neurotransmitter-gated ion channel clustering (GO:0072578)4.42687553
26presynaptic membrane assembly (GO:0097105)4.40327754
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.37484643
28response to pheromone (GO:0019236)4.34911320
29cerebellar granule cell differentiation (GO:0021707)4.33441971
30glutamate secretion (GO:0014047)4.29983939
31response to histamine (GO:0034776)4.28341615
32sperm-egg recognition (GO:0035036)4.24680895
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.17977993
34regulation of cilium movement (GO:0003352)4.15321518
35spermatid development (GO:0007286)4.14120107
36gamma-aminobutyric acid signaling pathway (GO:0007214)4.13499690
37presynaptic membrane organization (GO:0097090)4.09853931
38regulation of short-term neuronal synaptic plasticity (GO:0048172)4.09402612
39synaptic vesicle docking involved in exocytosis (GO:0016081)4.07822260
40cilium movement (GO:0003341)4.06474066
41glutamate receptor signaling pathway (GO:0007215)4.04307059
42ionotropic glutamate receptor signaling pathway (GO:0035235)4.03889628
43neuron-neuron synaptic transmission (GO:0007270)4.01826804
44behavioral response to cocaine (GO:0048148)4.01046145
45protein localization to cilium (GO:0061512)4.00770179
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99087389
47regulation of synaptic vesicle exocytosis (GO:2000300)3.92985424
48regulation of glutamate receptor signaling pathway (GO:1900449)3.89402141
49* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.82284221
50* ATP hydrolysis coupled proton transport (GO:0015991)3.82284221
51water-soluble vitamin biosynthetic process (GO:0042364)3.80418895
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.80008029
53cell-cell recognition (GO:0009988)3.79606668
54tryptophan catabolic process (GO:0006569)3.74950968
55indole-containing compound catabolic process (GO:0042436)3.74950968
56indolalkylamine catabolic process (GO:0046218)3.74950968
57piRNA metabolic process (GO:0034587)3.72986414
58protein K11-linked deubiquitination (GO:0035871)3.69554896
59positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69425267
60detection of light stimulus involved in visual perception (GO:0050908)3.68422366
61detection of light stimulus involved in sensory perception (GO:0050962)3.68422366
62synaptic transmission, glutamatergic (GO:0035249)3.66625484
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65202121
64neurotransmitter secretion (GO:0007269)3.63674677
65cellular ketone body metabolic process (GO:0046950)3.63099609
66striatum development (GO:0021756)3.62440927
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.61386815
68reproduction (GO:0000003)3.61050374
69positive regulation of synapse maturation (GO:0090129)3.54443461
70negative regulation of inclusion body assembly (GO:0090084)3.54259547
71binding of sperm to zona pellucida (GO:0007339)3.53917258
72indolalkylamine metabolic process (GO:0006586)3.52844340
73regulation of glutamate secretion (GO:0014048)3.48260532
74regulation of postsynaptic membrane potential (GO:0060078)3.45584007
75postsynaptic membrane organization (GO:0001941)3.42416235
76regulation of synaptic vesicle transport (GO:1902803)3.42102027
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.40549142
78transferrin transport (GO:0033572)3.34775631
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34206866
80long-term synaptic potentiation (GO:0060291)3.32776784
81ketone body metabolic process (GO:1902224)3.30765608
82axoneme assembly (GO:0035082)3.30390969
83negative regulation of dendrite morphogenesis (GO:0050774)3.27872012
84startle response (GO:0001964)3.27858535
85platelet dense granule organization (GO:0060155)3.27542529
86male meiosis (GO:0007140)3.26593833
87gamma-aminobutyric acid transport (GO:0015812)3.26408005
88cerebellar Purkinje cell differentiation (GO:0021702)3.26313518
89detection of calcium ion (GO:0005513)3.25168729
90regulation of protein kinase A signaling (GO:0010738)3.24134426
91kynurenine metabolic process (GO:0070189)3.21497252
92membrane depolarization during action potential (GO:0086010)3.20608396
93negative regulation of amino acid transport (GO:0051956)3.18281954
94nephron tubule morphogenesis (GO:0072078)3.17642109
95nephron epithelium morphogenesis (GO:0072088)3.17642109
96positive regulation of membrane potential (GO:0045838)3.16878304
97negative regulation of telomere maintenance (GO:0032205)3.15286611
98trivalent inorganic cation transport (GO:0072512)3.15245106
99ferric iron transport (GO:0015682)3.15245106
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14058675
101tryptophan metabolic process (GO:0006568)3.12062029
102membrane depolarization (GO:0051899)3.09942577
103regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.08478304
104regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.08478304
105prepulse inhibition (GO:0060134)3.07778017
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06664374
107nonmotile primary cilium assembly (GO:0035058)3.06649418
108centriole replication (GO:0007099)3.06448936
109cilium organization (GO:0044782)3.04942266
110sperm capacitation (GO:0048240)3.04443071
111positive regulation of cardiac muscle cell differentiation (GO:2000727)3.04386850
112DNA methylation involved in gamete generation (GO:0043046)3.03616731
113regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03181904
114DNA deamination (GO:0045006)3.03038700
115negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01670548
116protein polyglutamylation (GO:0018095)3.01513662
117regulation of neurotransmitter secretion (GO:0046928)3.00440539
118cilium assembly (GO:0042384)2.99996671
119cilium morphogenesis (GO:0060271)2.96586284
120regulation of synaptic plasticity (GO:0048167)2.96333906
121positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95800552
122kidney morphogenesis (GO:0060993)2.95146657
123serotonin metabolic process (GO:0042428)2.94874886
124replication fork processing (GO:0031297)2.94758051
125single fertilization (GO:0007338)2.93157531
126neurotransmitter transport (GO:0006836)2.91709524
127regulation of inclusion body assembly (GO:0090083)2.90051874
128synaptonemal complex organization (GO:0070193)2.89693341
129polyol catabolic process (GO:0046174)2.88903388
130retinal cone cell development (GO:0046549)2.86445850
131primary amino compound metabolic process (GO:1901160)2.85317803
132positive regulation of neurotransmitter secretion (GO:0001956)2.84897441
133regulation of neurotransmitter transport (GO:0051588)2.84113010
134long term synaptic depression (GO:0060292)2.82357827
135synaptic transmission, dopaminergic (GO:0001963)2.81391213
136reflex (GO:0060004)2.79292739
137regulation of action potential (GO:0098900)2.78709280
138reciprocal meiotic recombination (GO:0007131)2.78578789
139reciprocal DNA recombination (GO:0035825)2.78578789
140S-adenosylmethionine metabolic process (GO:0046500)2.77389281
141photoreceptor cell maintenance (GO:0045494)2.76691773
142respiratory chain complex IV assembly (GO:0008535)2.76501839
143regulation of hexokinase activity (GO:1903299)2.72495058
144regulation of glucokinase activity (GO:0033131)2.72495058
145neuronal action potential (GO:0019228)2.71874992
146sulfation (GO:0051923)2.70447022
147indole-containing compound metabolic process (GO:0042430)2.70321590
148synaptic transmission, cholinergic (GO:0007271)2.67043234
149positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.66536237
150recombinational repair (GO:0000725)2.61632493
151double-strand break repair via homologous recombination (GO:0000724)2.60004352
152auditory receptor cell stereocilium organization (GO:0060088)2.58530644
153neural tube formation (GO:0001841)2.58304307
154C4-dicarboxylate transport (GO:0015740)2.58253158
155rRNA catabolic process (GO:0016075)2.57556471
156regulation of meiosis I (GO:0060631)2.57268696
157behavioral response to ethanol (GO:0048149)2.56322669
158regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55016684
159adaptation of signaling pathway (GO:0023058)2.53966374
160preassembly of GPI anchor in ER membrane (GO:0016254)2.53288042
161rhodopsin mediated signaling pathway (GO:0016056)2.52500760
162negative regulation of reactive oxygen species metabolic process (GO:2000378)2.52464656
163negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51497175
164negative regulation of translation, ncRNA-mediated (GO:0040033)2.51497175
165regulation of translation, ncRNA-mediated (GO:0045974)2.51497175
166positive regulation of sodium ion transmembrane transport (GO:1902307)2.51347219
167DNA double-strand break processing (GO:0000729)2.51264807
168photoreceptor cell development (GO:0042461)2.49372935
169cAMP catabolic process (GO:0006198)2.48231076
170renal tubule morphogenesis (GO:0061333)2.47515972
171amine catabolic process (GO:0009310)2.47281686
172cellular biogenic amine catabolic process (GO:0042402)2.47281686
173regulation of telomere maintenance (GO:0032204)2.45819042
174L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44867627
175inner ear receptor stereocilium organization (GO:0060122)2.44629579
176detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42497032
177mannosylation (GO:0097502)2.42360635
178intraciliary transport (GO:0042073)2.39722425
179regulation of microtubule-based movement (GO:0060632)2.39429942
180cornea development in camera-type eye (GO:0061303)2.39216543
181protein import into peroxisome matrix (GO:0016558)2.37910698
182cytochrome complex assembly (GO:0017004)2.37330239
183axon ensheathment in central nervous system (GO:0032291)2.37248838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78260367
2GBX2_23144817_ChIP-Seq_PC3_Human3.84238534
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.95346991
4TAF15_26573619_Chip-Seq_HEK293_Human2.91314381
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.90616231
6IGF1R_20145208_ChIP-Seq_DFB_Human2.71991121
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.57802346
8REST_21632747_ChIP-Seq_MESCs_Mouse2.55895073
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49010165
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48516617
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43414531
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43355089
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20409686
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12351417
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04879846
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04761695
17* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04298683
18VDR_22108803_ChIP-Seq_LS180_Human2.03759888
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98753396
20* EWS_26573619_Chip-Seq_HEK293_Human1.90585929
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.90492534
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88848907
23ZNF274_21170338_ChIP-Seq_K562_Hela1.88754590
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88413403
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87293493
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.87047087
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83925078
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.82921673
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.82631548
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80579498
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80311734
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79241395
33FUS_26573619_Chip-Seq_HEK293_Human1.77844473
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77103460
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77007318
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75711512
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73273410
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73273410
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.71052957
40* P300_19829295_ChIP-Seq_ESCs_Human1.70269095
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.69767834
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67639981
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65173010
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64720768
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64354240
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62358853
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58221380
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.55863706
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.55214310
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.53595897
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52122622
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.50840857
53IRF1_19129219_ChIP-ChIP_H3396_Human1.49131184
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46944777
55TP53_22573176_ChIP-Seq_HFKS_Human1.46011085
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.45931101
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45479899
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43789256
59AR_25329375_ChIP-Seq_VCAP_Human1.43700968
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43357639
61ER_23166858_ChIP-Seq_MCF-7_Human1.41696162
62RNF2_27304074_Chip-Seq_NSC_Mouse1.41402959
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40891207
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.39705879
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39635708
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38396814
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.36691486
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35692182
69KDM2B_26808549_Chip-Seq_REH_Human1.35550477
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35549867
71DROSHA_22980978_ChIP-Seq_HELA_Human1.34314806
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33206942
73NANOG_19829295_ChIP-Seq_ESCs_Human1.31638654
74SOX2_19829295_ChIP-Seq_ESCs_Human1.31638654
75* TCF4_22108803_ChIP-Seq_LS180_Human1.31548730
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.30459003
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29194496
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28149795
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28003930
80AR_21572438_ChIP-Seq_LNCaP_Human1.27979466
81TCF4_23295773_ChIP-Seq_U87_Human1.27470908
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27337150
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26985468
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25526338
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25303565
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25224967
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24138262
88MYC_18940864_ChIP-ChIP_HL60_Human1.22500877
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22268238
90P53_22387025_ChIP-Seq_ESCs_Mouse1.22004763
91* STAT3_23295773_ChIP-Seq_U87_Human1.21949597
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21903007
93CBP_20019798_ChIP-Seq_JUKART_Human1.21903007
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.20705976
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20705976
96* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19998536
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19136801
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18425210
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17555857
100GATA3_21878914_ChIP-Seq_MCF-7_Human1.17509957
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.17356786
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16426461
103SOX9_26525672_Chip-Seq_HEART_Mouse1.16290181
104* NOTCH1_21737748_ChIP-Seq_TLL_Human1.15823104
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.15446231
106HOXB7_26014856_ChIP-Seq_BT474_Human1.15321860
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15312824
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.15013447
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14845593
110* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14477429
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12677990
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12677990
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.12571598
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12541341
115NCOR_22424771_ChIP-Seq_293T_Human1.12306029
116* BCAT_22108803_ChIP-Seq_LS180_Human1.11234114
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.10558702
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.10473142
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.10386275
120* RUNX2_22187159_ChIP-Seq_PCA_Human1.09985010
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09559418
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08759727
123P300_18555785_Chip-Seq_ESCs_Mouse1.07627250
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07521829
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07476458
126SOX2_18555785_Chip-Seq_ESCs_Mouse1.07239901
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05838968
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.04909891
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04568930
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03704534
131JUN_21703547_ChIP-Seq_K562_Human1.03582471
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03420408
133AR_20517297_ChIP-Seq_VCAP_Human1.03107690
134STAT3_18555785_Chip-Seq_ESCs_Mouse1.01405912
135GABP_17652178_ChIP-ChIP_JURKAT_Human1.00891552
136AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00673048
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00100260
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95894643
139ERA_21632823_ChIP-Seq_H3396_Human0.95780248
140MYC_19829295_ChIP-Seq_ESCs_Human0.95428005
141CDX2_22108803_ChIP-Seq_LS180_Human0.94596362
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.93290733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.09385422
2MP0003880_abnormal_central_pattern5.01510797
3MP0004859_abnormal_synaptic_plasticity4.38366645
4MP0009046_muscle_twitch3.99249148
5MP0003635_abnormal_synaptic_transmissio3.79104406
6MP0009745_abnormal_behavioral_response3.39750439
7MP0001968_abnormal_touch/_nociception3.26149138
8MP0004270_analgesia3.19517846
9MP0002064_seizures3.10260091
10MP0002063_abnormal_learning/memory/cond3.07936139
11MP0002822_catalepsy2.81509272
12MP0002572_abnormal_emotion/affect_behav2.78343993
13MP0002736_abnormal_nociception_after2.68226256
14MP0000569_abnormal_digit_pigmentation2.61297348
15MP0003195_calcinosis2.58448693
16MP0001486_abnormal_startle_reflex2.54050362
17MP0002272_abnormal_nervous_system2.51233934
18MP0001984_abnormal_olfaction2.50375033
19MP0001440_abnormal_grooming_behavior2.49201801
20MP0003136_yellow_coat_color2.42752148
21MP0002734_abnormal_mechanical_nocicepti2.38464701
22MP0006292_abnormal_olfactory_placode2.32633642
23MP0002067_abnormal_sensory_capabilities2.24075321
24MP0003698_abnormal_male_reproductive2.20965345
25MP0002735_abnormal_chemical_nociception2.15412081
26MP0003879_abnormal_hair_cell1.96628740
27MP0001501_abnormal_sleep_pattern1.93148114
28MP0008875_abnormal_xenobiotic_pharmacok1.90469154
29MP0001529_abnormal_vocalization1.90400325
30MP0002733_abnormal_thermal_nociception1.89567150
31MP0006072_abnormal_retinal_apoptosis1.88718217
32MP0008877_abnormal_DNA_methylation1.85675217
33MP0005253_abnormal_eye_physiology1.82081773
34MP0008569_lethality_at_weaning1.79251304
35MP0005645_abnormal_hypothalamus_physiol1.78640754
36MP0001970_abnormal_pain_threshold1.76734874
37MP0002837_dystrophic_cardiac_calcinosis1.74498295
38MP0001929_abnormal_gametogenesis1.70560953
39MP0002638_abnormal_pupillary_reflex1.69446099
40MP0002653_abnormal_ependyma_morphology1.64244942
41MP0002557_abnormal_social/conspecific_i1.62513876
42MP0005423_abnormal_somatic_nervous1.58113142
43MP0002184_abnormal_innervation1.57327557
44MP0004133_heterotaxia1.56635486
45MP0005386_behavior/neurological_phenoty1.56324880
46MP0004924_abnormal_behavior1.56324880
47MP0000427_abnormal_hair_cycle1.53289451
48MP0005646_abnormal_pituitary_gland1.51845675
49MP0001188_hyperpigmentation1.41776407
50MP0000778_abnormal_nervous_system1.39348458
51MP0005174_abnormal_tail_pigmentation1.35198683
52MP0006276_abnormal_autonomic_nervous1.33030623
53MP0002938_white_spotting1.32240459
54MP0000372_irregular_coat_pigmentation1.30788457
55MP0002066_abnormal_motor_capabilities/c1.30462866
56MP0001905_abnormal_dopamine_level1.29677371
57MP0005377_hearing/vestibular/ear_phenot1.28955748
58MP0003878_abnormal_ear_physiology1.28955748
59MP0004811_abnormal_neuron_physiology1.27380171
60MP0003329_amyloid_beta_deposits1.26418998
61MP0002234_abnormal_pharynx_morphology1.26356967
62MP0005171_absent_coat_pigmentation1.25728093
63MP0004142_abnormal_muscle_tone1.24287161
64MP0008789_abnormal_olfactory_epithelium1.23007405
65MP0002161_abnormal_fertility/fecundity1.21805083
66MP0004742_abnormal_vestibular_system1.19835219
67MP0002095_abnormal_skin_pigmentation1.16685891
68MP0003718_maternal_effect1.16670901
69MP0002876_abnormal_thyroid_physiology1.16325861
70MP0003633_abnormal_nervous_system1.14560149
71MP0008872_abnormal_physiological_respon1.11403310
72MP0002882_abnormal_neuron_morphology1.11166251
73MP0000955_abnormal_spinal_cord1.10562409
74MP0000013_abnormal_adipose_tissue1.09297882
75MP0004036_abnormal_muscle_relaxation1.08997308
76MP0000383_abnormal_hair_follicle1.07772274
77MP0005195_abnormal_posterior_eye1.07286951
78MP0009780_abnormal_chondrocyte_physiolo1.06118442
79MP0004858_abnormal_nervous_system1.05988611
80MP0002160_abnormal_reproductive_system1.05898552
81MP0001986_abnormal_taste_sensitivity1.05013956
82MP0005499_abnormal_olfactory_system1.04654641
83MP0005394_taste/olfaction_phenotype1.04654641
84MP0001502_abnormal_circadian_rhythm1.03073843
85MP0002928_abnormal_bile_duct1.02470677
86MP0005084_abnormal_gallbladder_morpholo1.00038129
87MP0001963_abnormal_hearing_physiology0.99407948
88MP0010386_abnormal_urinary_bladder0.99306633
89MP0004233_abnormal_muscle_weight0.98721547
90MP0004145_abnormal_muscle_electrophysio0.97380352
91MP0002210_abnormal_sex_determination0.97368349
92MP0005551_abnormal_eye_electrophysiolog0.97318481
93MP0003631_nervous_system_phenotype0.97122661
94MP0004484_altered_response_of0.95278693
95MP0004215_abnormal_myocardial_fiber0.93103190
96MP0002152_abnormal_brain_morphology0.92266684
97MP0002909_abnormal_adrenal_gland0.92063181
98MP0002229_neurodegeneration0.90331886
99MP0005075_abnormal_melanosome_morpholog0.90160632
100MP0006035_abnormal_mitochondrial_morpho0.89202957
101MP0003646_muscle_fatigue0.88938063
102MP0008874_decreased_physiological_sensi0.88826743
103MP0000751_myopathy0.87511363
104MP0001919_abnormal_reproductive_system0.87198239
105MP0004085_abnormal_heartbeat0.86971291
106MP0003011_delayed_dark_adaptation0.84601900
107MP0001324_abnormal_eye_pigmentation0.82599020
108MP0003183_abnormal_peptide_metabolism0.81707141
109MP0000015_abnormal_ear_pigmentation0.81240987
110MP0008058_abnormal_DNA_repair0.80674406
111MP0003121_genomic_imprinting0.80329744
112MP0001145_abnormal_male_reproductive0.79991780
113MP0001764_abnormal_homeostasis0.79086614
114MP0002693_abnormal_pancreas_physiology0.78919182
115MP0005623_abnormal_meninges_morphology0.78307771
116MP0003119_abnormal_digestive_system0.78248731
117MP0003137_abnormal_impulse_conducting0.77106402
118MP0001485_abnormal_pinna_reflex0.76455901
119MP0002163_abnormal_gland_morphology0.73786479
120MP0000653_abnormal_sex_gland0.73642368
121MP0005535_abnormal_body_temperature0.73272445
122MP0002069_abnormal_eating/drinking_beha0.72928092
123MP0004147_increased_porphyrin_level0.71081332
124MP0003787_abnormal_imprinting0.70552038
125MP0002752_abnormal_somatic_nervous0.67760170
126MP0005379_endocrine/exocrine_gland_phen0.67694079
127MP0004043_abnormal_pH_regulation0.67373138
128MP0001765_abnormal_ion_homeostasis0.64232525
129MP0009697_abnormal_copulation0.63663920
130MP0000026_abnormal_inner_ear0.61712411
131MP0002102_abnormal_ear_morphology0.59080593
132MP0005389_reproductive_system_phenotype0.58196427
133MP0004885_abnormal_endolymph0.57902675
134MP0000604_amyloidosis0.57444468
135MP0000631_abnormal_neuroendocrine_gland0.54874294
136MP0008260_abnormal_autophagy0.52286111
137MP0001664_abnormal_digestion0.51926201

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)7.90756319
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.90756319
3Focal motor seizures (HP:0011153)7.42170633
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.30569536
5Abnormal respiratory motile cilium morphology (HP:0005938)5.52795991
6Abnormal respiratory epithelium morphology (HP:0012253)5.52795991
7Abnormal respiratory motile cilium physiology (HP:0012261)5.46381176
8Epileptic encephalopathy (HP:0200134)5.16478178
9Atonic seizures (HP:0010819)5.12495709
10Abnormal ciliary motility (HP:0012262)4.85929018
11Hyperventilation (HP:0002883)4.72934828
12Focal seizures (HP:0007359)4.69683611
13Rhinitis (HP:0012384)4.59656820
14Pancreatic cysts (HP:0001737)4.57793381
15Pancreatic fibrosis (HP:0100732)4.35112581
16True hermaphroditism (HP:0010459)4.05987653
17Type II lissencephaly (HP:0007260)4.01830337
18Febrile seizures (HP:0002373)3.88320985
19Absence seizures (HP:0002121)3.85538157
20Progressive cerebellar ataxia (HP:0002073)3.81043686
21Gaze-evoked nystagmus (HP:0000640)3.75129951
22Myokymia (HP:0002411)3.74538501
23Congenital stationary night blindness (HP:0007642)3.69626505
24Abnormality of the renal cortex (HP:0011035)3.69340918
25Chronic bronchitis (HP:0004469)3.61141621
26Infertility (HP:0000789)3.60060793
27Dialeptic seizures (HP:0011146)3.59255895
28Medial flaring of the eyebrow (HP:0010747)3.54981538
29Abnormality of the renal medulla (HP:0100957)3.42616012
30Gait imbalance (HP:0002141)3.35703640
31Dysmetric saccades (HP:0000641)3.30315603
32Congenital primary aphakia (HP:0007707)3.20335750
33Broad-based gait (HP:0002136)3.19155314
34Cystic liver disease (HP:0006706)3.16101013
35Visual hallucinations (HP:0002367)3.13867137
36Renal cortical cysts (HP:0000803)3.08235652
37Generalized tonic-clonic seizures (HP:0002069)3.00086918
38Chronic hepatic failure (HP:0100626)2.92707057
39Nephrogenic diabetes insipidus (HP:0009806)2.91472989
40Tubular atrophy (HP:0000092)2.85780512
41Sensory axonal neuropathy (HP:0003390)2.79231169
42Acute necrotizing encephalopathy (HP:0006965)2.75667250
43Truncal ataxia (HP:0002078)2.75125821
44Cerebellar dysplasia (HP:0007033)2.69459174
45Abnormal biliary tract physiology (HP:0012439)2.67689685
46Bile duct proliferation (HP:0001408)2.67689685
47Inability to walk (HP:0002540)2.67420759
48Abnormal drinking behavior (HP:0030082)2.66296734
49Polydipsia (HP:0001959)2.66296734
50Dysdiadochokinesis (HP:0002075)2.66054218
51Pendular nystagmus (HP:0012043)2.64252337
52Attenuation of retinal blood vessels (HP:0007843)2.64198307
53Sclerocornea (HP:0000647)2.58478355
54Poor coordination (HP:0002370)2.56132694
55Lissencephaly (HP:0001339)2.55310194
56Abnormal hair whorl (HP:0010721)2.52220786
57Impaired smooth pursuit (HP:0007772)2.51878640
58Progressive macrocephaly (HP:0004481)2.50564636
59Amblyopia (HP:0000646)2.48673525
60Abnormal mitochondria in muscle tissue (HP:0008316)2.46174298
61Abnormality of the labia minora (HP:0012880)2.45752455
62Impaired vibration sensation in the lower limbs (HP:0002166)2.45466929
63Abnormal eating behavior (HP:0100738)2.41090864
64Abolished electroretinogram (ERG) (HP:0000550)2.40130925
65Hyperalaninemia (HP:0003348)2.38566029
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38566029
67Abnormality of alanine metabolism (HP:0010916)2.38566029
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.37330691
69Vaginal atresia (HP:0000148)2.35840230
70Genital tract atresia (HP:0001827)2.34744579
71Large for gestational age (HP:0001520)2.33102495
72Abnormality of ocular smooth pursuit (HP:0000617)2.29426524
73Methylmalonic acidemia (HP:0002912)2.27701932
74Keratoconus (HP:0000563)2.27060546
75Increased corneal curvature (HP:0100692)2.27060546
76Congenital hepatic fibrosis (HP:0002612)2.25572404
77Poor eye contact (HP:0000817)2.25356502
78Protruding tongue (HP:0010808)2.24953180
79Epileptiform EEG discharges (HP:0011182)2.22332408
80Pachygyria (HP:0001302)2.18133472
81Progressive inability to walk (HP:0002505)2.17507370
82Male pseudohermaphroditism (HP:0000037)2.16849077
83Retinal dysplasia (HP:0007973)2.15350617
84Nasal polyposis (HP:0100582)2.14965349
85Absent speech (HP:0001344)2.13310730
86Polyuria (HP:0000103)2.12799214
87Abnormal rod and cone electroretinograms (HP:0008323)2.12413143
88Nephronophthisis (HP:0000090)2.11620492
89Optic nerve hypoplasia (HP:0000609)2.11176666
90Postaxial foot polydactyly (HP:0001830)2.10900698
91Acute encephalopathy (HP:0006846)2.09827565
92Anencephaly (HP:0002323)2.09588658
93Annular pancreas (HP:0001734)2.09205226
94Dysmetria (HP:0001310)2.08835843
95Impaired vibratory sensation (HP:0002495)2.08820014
96Hemiparesis (HP:0001269)2.08737568
97Status epilepticus (HP:0002133)2.08615396
98Pheochromocytoma (HP:0002666)2.05799041
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05156029
100Abnormal social behavior (HP:0012433)2.05130931
101Impaired social interactions (HP:0000735)2.05130931
102Bronchiectasis (HP:0002110)2.05023980
103Urinary bladder sphincter dysfunction (HP:0002839)2.02883552
104Furrowed tongue (HP:0000221)2.02274907
105Abnormality of saccadic eye movements (HP:0000570)2.02164913
106Patellar aplasia (HP:0006443)2.00981683
107Abnormality of the lower motor neuron (HP:0002366)2.00649340
108Specific learning disability (HP:0001328)1.98916808
109Scanning speech (HP:0002168)1.98873448
110Poor suck (HP:0002033)1.97448272
111Mitochondrial inheritance (HP:0001427)1.97140174
112Polyphagia (HP:0002591)1.96863800
113Termporal pattern (HP:0011008)1.96808598
114Insidious onset (HP:0003587)1.96808598
115Drooling (HP:0002307)1.95239125
116Excessive salivation (HP:0003781)1.95239125
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.93095516
118Aplasia/Hypoplasia of the lens (HP:0008063)1.92762289
119Neuroendocrine neoplasm (HP:0100634)1.91554945
120Cholecystitis (HP:0001082)1.91292027
121Abnormal gallbladder physiology (HP:0012438)1.91292027
122Abnormality of the pons (HP:0007361)1.91140294
123Hypoplasia of the pons (HP:0012110)1.90869529
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.89838655
125Occipital encephalocele (HP:0002085)1.89714674
126Hypothermia (HP:0002045)1.89563611
127Supernumerary spleens (HP:0009799)1.89184304
128Optic disc pallor (HP:0000543)1.88529443
129Hyperglycinemia (HP:0002154)1.88504934
130Gait ataxia (HP:0002066)1.88431589
131Delusions (HP:0000746)1.88191140
132Postaxial hand polydactyly (HP:0001162)1.87584676
133Aplasia/Hypoplasia of the patella (HP:0006498)1.87537609
134Stereotypic behavior (HP:0000733)1.87351922
135Clumsiness (HP:0002312)1.86000872
136Severe muscular hypotonia (HP:0006829)1.84826270
137Chorioretinal atrophy (HP:0000533)1.84802152
138Decreased central vision (HP:0007663)1.84429693
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83880648
140EEG with generalized epileptiform discharges (HP:0011198)1.83743256
141Resting tremor (HP:0002322)1.83025784
142Decreased circulating renin level (HP:0003351)1.82377344
143Generalized myoclonic seizures (HP:0002123)1.80847880
144Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76969776
145Abnormality of the renal collecting system (HP:0004742)1.75854127
146Ketosis (HP:0001946)1.75810289
147Bony spicule pigmentary retinopathy (HP:0007737)1.75402475
148Fetal akinesia sequence (HP:0001989)1.75061212
149Depression (HP:0000716)1.74449579
150Limb ataxia (HP:0002070)1.74317063
151Concave nail (HP:0001598)1.73633351
152Preaxial hand polydactyly (HP:0001177)1.72978572
153Methylmalonic aciduria (HP:0012120)1.72544045
154Abnormal urine output (HP:0012590)1.72386768
155Abnormality of the ileum (HP:0001549)1.71364850
156Congenital, generalized hypertrichosis (HP:0004540)1.69248325
157Dandy-Walker malformation (HP:0001305)1.69233858
158Fair hair (HP:0002286)1.69087822
159Aplasia/Hypoplasia of the spleen (HP:0010451)1.68708520
160Duplicated collecting system (HP:0000081)1.67947890
161Increased CSF lactate (HP:0002490)1.67942418
162Genetic anticipation (HP:0003743)1.67527570
163Tachypnea (HP:0002789)1.67291180
164Hypoplastic iliac wings (HP:0002866)1.67084574
165Molar tooth sign on MRI (HP:0002419)1.64488022
166Abnormality of midbrain morphology (HP:0002418)1.64488022
167Blue irides (HP:0000635)1.64196691
168Degeneration of the lateral corticospinal tracts (HP:0002314)1.61381490
169Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.61381490
170Hypsarrhythmia (HP:0002521)1.61303067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.41959906
2FRK4.82187850
3PDK33.63562970
4PDK43.63562970
5CDK192.97356011
6MAP2K72.93924337
7EPHA42.93589054
8MAP3K42.90132274
9MAP4K22.89352629
10INSRR2.87391704
11NTRK32.78161046
12CCNB12.62340006
13MAP3K122.52494756
14GRK12.41575855
15ZAK2.38506442
16NUAK12.37909310
17RIPK42.36110617
18PNCK2.35741304
19PDK22.35622499
20PLK22.26116443
21DAPK22.16247516
22SIK32.11299574
23MAP3K92.03644802
24TAOK32.00702761
25AKT31.98178244
26MINK11.94231854
27OXSR11.87182819
28MAP2K41.77014087
29ARAF1.74613867
30PTK2B1.72266817
31DAPK11.72153855
32ACVR1B1.65867213
33CAMKK21.59847291
34TLK11.58074972
35TXK1.49566134
36KSR11.46089877
37STK38L1.33054154
38TNIK1.32283378
39BRAF1.20065808
40TESK11.18129656
41PAK61.17170168
42STK391.16750597
43BCR1.16653657
44PAK31.16156463
45PRPF4B1.15845554
46TGFBR11.15353813
47PRKD31.14927338
48PRKCG1.10909221
49BMPR21.09699127
50GRK51.07519007
51NTRK21.06422140
52CSNK1G21.03817109
53NEK21.03783502
54CAMKK11.01380675
55CAMK2A1.01359580
56VRK11.00549740
57CSNK1G30.99884729
58DYRK20.99203640
59MAPK150.99127755
60LATS10.98131262
61OBSCN0.97385131
62CSNK1A1L0.97330678
63BRSK20.96075005
64CDK180.95582701
65MARK10.95177767
66CDK50.94691147
67STK380.93959500
68CSNK1G10.93910059
69MAPK130.93694006
70NLK0.90733242
71KSR20.86349512
72TRIM280.86306178
73WNK40.83584894
74SGK20.83392311
75PDK10.82476661
76PHKG10.82341021
77PHKG20.82341021
78NME10.82023960
79CDK150.81211980
80CDK140.79929077
81BCKDK0.76400028
82CAMK2B0.75685302
83SGK2230.72546074
84SGK4940.72546074
85CDK11A0.69821180
86PIK3CA0.68986324
87PDPK10.67658386
88TSSK60.67310382
89RAF10.66359225
90NTRK10.66042421
91FGFR20.65544314
92MAPKAPK50.64882687
93MAPKAPK30.64736478
94PRKAA20.64636211
95PRKCQ0.63982620
96PLK40.63664425
97FES0.63492700
98MAP3K60.62045302
99EPHA30.60623885
100WEE10.59498677
101PKN10.59461001
102MKNK10.56951510
103MAP3K70.55812561
104WNK10.55275987
105VRK20.54765383
106MAP2K60.54329546
107FGR0.54174504
108BMPR1B0.53932660
109MUSK0.53294772
110CSNK1D0.53032477
111CSNK1A10.52281017
112TNK20.51916217
113SIK20.51751675
114CDK80.50341523
115SGK10.49791454
116PRKCE0.49502747
117EIF2AK30.49278239
118ICK0.48640569
119STK110.47707548
120CDK30.46479489
121PRKAA10.45280527
122MARK30.45064888
123MAPK70.44950370
124ATR0.42891582
125ADRBK20.42849157
126TEC0.42610389
127PINK10.42581356
128MYLK0.41975751
129DYRK1A0.41817614
130ERBB30.41695959
131RPS6KA50.40658589
132TIE10.40577855
133MAPK120.40424136
134TYRO30.40268156
135IRAK10.39489873
136MAP2K10.39000579
137TAF10.38255803
138ATM0.37472599
139PRKCZ0.36726495
140PRKACA0.36401086
141STK30.36053777
142NEK60.35981132
143ITK0.35864864
144PRKCI0.35463119
145SGK30.35286651
146DAPK30.35277000
147MAP3K130.34980711
148CAMK10.34683218
149GRK70.34566930
150ADRBK10.34283259
151PRKACB0.34254574
152CAMK2G0.33688790
153CAMK2D0.30941406
154FER0.28707729
155PRKG10.28659069
156PRKCB0.26163165
157MKNK20.24475405
158RPS6KA30.24171212
159PRKCA0.24114728
160MAP3K20.23955894
161PLK30.23747254
162UHMK10.23399123
163WNK30.22344824

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.20024047
2Synaptic vesicle cycle_Homo sapiens_hsa047213.73937304
3Collecting duct acid secretion_Homo sapiens_hsa049663.35345901
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80647178
5Amphetamine addiction_Homo sapiens_hsa050312.79521053
6Long-term potentiation_Homo sapiens_hsa047202.77900585
7Nitrogen metabolism_Homo sapiens_hsa009102.71178797
8Morphine addiction_Homo sapiens_hsa050322.58380051
9Olfactory transduction_Homo sapiens_hsa047402.56132729
10Linoleic acid metabolism_Homo sapiens_hsa005912.55135939
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47858109
12GABAergic synapse_Homo sapiens_hsa047272.47375725
13Circadian entrainment_Homo sapiens_hsa047132.43237296
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.40843869
15Taste transduction_Homo sapiens_hsa047422.38570495
16Glutamatergic synapse_Homo sapiens_hsa047242.29470972
17Oxidative phosphorylation_Homo sapiens_hsa001902.25594876
18Homologous recombination_Homo sapiens_hsa034402.18561508
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16120899
20Renin secretion_Homo sapiens_hsa049242.09807742
21Salivary secretion_Homo sapiens_hsa049702.09782791
22Dopaminergic synapse_Homo sapiens_hsa047282.03563011
23Fanconi anemia pathway_Homo sapiens_hsa034601.88974929
24Protein export_Homo sapiens_hsa030601.76292702
25Tryptophan metabolism_Homo sapiens_hsa003801.75105543
26Long-term depression_Homo sapiens_hsa047301.75056920
27Vibrio cholerae infection_Homo sapiens_hsa051101.74423546
28Selenocompound metabolism_Homo sapiens_hsa004501.74137690
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71803051
30Cardiac muscle contraction_Homo sapiens_hsa042601.69603460
31Insulin secretion_Homo sapiens_hsa049111.68317296
32Calcium signaling pathway_Homo sapiens_hsa040201.68206390
33Basal transcription factors_Homo sapiens_hsa030221.66088497
34Caffeine metabolism_Homo sapiens_hsa002321.64934861
35Serotonergic synapse_Homo sapiens_hsa047261.63000673
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60990121
37ABC transporters_Homo sapiens_hsa020101.60952554
38Alzheimers disease_Homo sapiens_hsa050101.60053761
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58532830
40Gastric acid secretion_Homo sapiens_hsa049711.53671583
41Parkinsons disease_Homo sapiens_hsa050121.52196961
42Huntingtons disease_Homo sapiens_hsa050161.49461761
43Oxytocin signaling pathway_Homo sapiens_hsa049211.45387310
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41841446
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41767150
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40006170
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36619303
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36432205
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36008860
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31275069
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31121105
52Cholinergic synapse_Homo sapiens_hsa047251.29120961
53RNA polymerase_Homo sapiens_hsa030201.28978677
54Cocaine addiction_Homo sapiens_hsa050301.28936808
55Pyruvate metabolism_Homo sapiens_hsa006201.22451586
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.22294766
57Peroxisome_Homo sapiens_hsa041461.20935967
58One carbon pool by folate_Homo sapiens_hsa006701.20152483
59Chemical carcinogenesis_Homo sapiens_hsa052041.18352197
60RNA degradation_Homo sapiens_hsa030181.18261497
61Oocyte meiosis_Homo sapiens_hsa041141.17379233
62Vitamin B6 metabolism_Homo sapiens_hsa007501.15293710
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14948051
64beta-Alanine metabolism_Homo sapiens_hsa004101.13249605
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12281921
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.08840541
67Phototransduction_Homo sapiens_hsa047441.05864473
68cAMP signaling pathway_Homo sapiens_hsa040241.04981872
69Gap junction_Homo sapiens_hsa045401.03929089
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03895928
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02791420
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02470272
73Glucagon signaling pathway_Homo sapiens_hsa049221.02115326
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01923616
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00601952
76Retinol metabolism_Homo sapiens_hsa008300.94763754
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.92896363
78Rheumatoid arthritis_Homo sapiens_hsa053230.91709762
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89856153
80Estrogen signaling pathway_Homo sapiens_hsa049150.89431889
81Arachidonic acid metabolism_Homo sapiens_hsa005900.88269151
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87258462
83Non-homologous end-joining_Homo sapiens_hsa034500.84747564
84Histidine metabolism_Homo sapiens_hsa003400.83004005
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81886894
86Fat digestion and absorption_Homo sapiens_hsa049750.80307041
87GnRH signaling pathway_Homo sapiens_hsa049120.79850971
88Ovarian steroidogenesis_Homo sapiens_hsa049130.76465993
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75932724
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74958268
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74744690
92Pancreatic secretion_Homo sapiens_hsa049720.68449375
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65471158
94Dorso-ventral axis formation_Homo sapiens_hsa043200.64102411
95Axon guidance_Homo sapiens_hsa043600.63518067
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62996001
97Primary immunodeficiency_Homo sapiens_hsa053400.62838127
98Inositol phosphate metabolism_Homo sapiens_hsa005620.62479160
99Mineral absorption_Homo sapiens_hsa049780.62391357
100Metabolic pathways_Homo sapiens_hsa011000.61568800
101Fatty acid degradation_Homo sapiens_hsa000710.61181648
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60565417
103ErbB signaling pathway_Homo sapiens_hsa040120.59138928
104Melanogenesis_Homo sapiens_hsa049160.59137738
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.57895778
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57389318
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57182810
108Vitamin digestion and absorption_Homo sapiens_hsa049770.56166956
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55758364
110Thyroid hormone synthesis_Homo sapiens_hsa049180.53912637
111African trypanosomiasis_Homo sapiens_hsa051430.52671198
112Circadian rhythm_Homo sapiens_hsa047100.52588855
113MAPK signaling pathway_Homo sapiens_hsa040100.52273073
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52087750
115Nucleotide excision repair_Homo sapiens_hsa034200.51908531
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.51494240
117Fatty acid biosynthesis_Homo sapiens_hsa000610.51358346
118Type II diabetes mellitus_Homo sapiens_hsa049300.51173137
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50977917
120Type I diabetes mellitus_Homo sapiens_hsa049400.49667647
121Fructose and mannose metabolism_Homo sapiens_hsa000510.47950038
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47665550
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47204738
124Lysine degradation_Homo sapiens_hsa003100.46832405
125Basal cell carcinoma_Homo sapiens_hsa052170.46532075
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45843333
127Hedgehog signaling pathway_Homo sapiens_hsa043400.44111279
128Phagosome_Homo sapiens_hsa041450.42995098
129Propanoate metabolism_Homo sapiens_hsa006400.42277990
130Dilated cardiomyopathy_Homo sapiens_hsa054140.41526133
131Glioma_Homo sapiens_hsa052140.40837895
132Fatty acid metabolism_Homo sapiens_hsa012120.40566849
133Pyrimidine metabolism_Homo sapiens_hsa002400.36813919
134Ras signaling pathway_Homo sapiens_hsa040140.35624922
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.35600772
136VEGF signaling pathway_Homo sapiens_hsa043700.33559269
137Ether lipid metabolism_Homo sapiens_hsa005650.33327403
138Sulfur relay system_Homo sapiens_hsa041220.32862097
139Alcoholism_Homo sapiens_hsa050340.32231403
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31447104
141Glycerolipid metabolism_Homo sapiens_hsa005610.30595926
142Butanoate metabolism_Homo sapiens_hsa006500.30365809
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30117458
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29214214
145Regulation of autophagy_Homo sapiens_hsa041400.26793486
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25476428
147Wnt signaling pathway_Homo sapiens_hsa043100.22534353
148Carbon metabolism_Homo sapiens_hsa012000.22426601
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.22062193
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21967245
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21622462
152Purine metabolism_Homo sapiens_hsa002300.21413963
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21402153
154Rap1 signaling pathway_Homo sapiens_hsa040150.19793950
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19444032

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