ATP6V0A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.90039703
2drug transmembrane transport (GO:0006855)9.38803031
3axonemal dynein complex assembly (GO:0070286)8.27917563
4drug transport (GO:0015893)8.12775799
5organic cation transport (GO:0015695)7.97679965
6lysine metabolic process (GO:0006553)7.78916338
7lysine catabolic process (GO:0006554)7.78916338
8phosphate ion transport (GO:0006817)7.72954100
9renal absorption (GO:0070293)6.62093740
10pyrimidine-containing compound transmembrane transport (GO:0072531)6.56904875
11quaternary ammonium group transport (GO:0015697)6.53380835
12cilium or flagellum-dependent cell motility (GO:0001539)6.51659735
13* excretion (GO:0007588)6.49684234
14sphingosine metabolic process (GO:0006670)6.45758292
15response to mercury ion (GO:0046689)6.45680858
16phosphate ion transmembrane transport (GO:0035435)6.44213831
17diol metabolic process (GO:0034311)6.37335784
18cysteine metabolic process (GO:0006534)6.10253554
19glyoxylate metabolic process (GO:0046487)5.93440452
20sphingoid metabolic process (GO:0046519)5.90490503
21cilium movement (GO:0003341)5.83815706
22drug catabolic process (GO:0042737)5.79853618
23modified amino acid transport (GO:0072337)5.68408728
24motile cilium assembly (GO:0044458)5.62259488
25exogenous drug catabolic process (GO:0042738)5.51361085
26vitamin D metabolic process (GO:0042359)5.50283560
27nonribosomal peptide biosynthetic process (GO:0019184)5.48153621
28trivalent inorganic anion homeostasis (GO:0072506)5.47889526
29phosphate ion homeostasis (GO:0055062)5.47889526
30tricarboxylic acid metabolic process (GO:0072350)5.34815376
31metanephric tubule development (GO:0072170)5.30935341
32metanephric nephron tubule development (GO:0072234)5.30935341
33primary alcohol catabolic process (GO:0034310)5.17607033
34epithelial cilium movement (GO:0003351)5.02558209
35aspartate family amino acid catabolic process (GO:0009068)4.97799420
36glutathione biosynthetic process (GO:0006750)4.92858343
37toxin transport (GO:1901998)4.92445276
38carnitine transport (GO:0015879)4.92332826
39amino-acid betaine transport (GO:0015838)4.92332826
40metanephric nephron epithelium development (GO:0072243)4.87985454
41desmosome organization (GO:0002934)4.86428919
42branched-chain amino acid metabolic process (GO:0009081)4.86404526
43regulation of cellular respiration (GO:0043457)4.84810852
44short-chain fatty acid metabolic process (GO:0046459)4.82187218
45polyol transport (GO:0015791)4.79311311
46homocysteine metabolic process (GO:0050667)4.78900446
47serine family amino acid catabolic process (GO:0009071)4.75267461
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.58522691
49amino-acid betaine metabolic process (GO:0006577)4.56934183
50glycoside metabolic process (GO:0016137)4.47008912
51fructose metabolic process (GO:0006000)4.44800782
52metanephric epithelium development (GO:0072207)4.44664982
53serine family amino acid metabolic process (GO:0009069)4.43900196
54valine metabolic process (GO:0006573)4.43849429
55proline metabolic process (GO:0006560)4.35571223
56regulation of oxidative phosphorylation (GO:0002082)4.35451706
57nephron tubule development (GO:0072080)4.34944210
58vitamin transport (GO:0051180)4.33941406
59tryptophan catabolic process (GO:0006569)4.29827211
60indole-containing compound catabolic process (GO:0042436)4.29827211
61indolalkylamine catabolic process (GO:0046218)4.29827211
62intestinal epithelial cell development (GO:0060576)4.27892339
63regulation of hippo signaling (GO:0035330)4.27694552
64bundle of His cell to Purkinje myocyte communication (GO:0086069)4.22888200
652-oxoglutarate metabolic process (GO:0006103)4.22589109
66cellular modified amino acid catabolic process (GO:0042219)4.18143647
67aromatic amino acid family catabolic process (GO:0009074)4.16655916
68peptide catabolic process (GO:0043171)4.10765844
69carnitine metabolic process (GO:0009437)4.10219528
70L-phenylalanine metabolic process (GO:0006558)4.09603449
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.09603449
72multicellular organismal water homeostasis (GO:0050891)4.09254795
73molting cycle (GO:0042303)4.05673456
74hair cycle (GO:0042633)4.05673456
75branched-chain amino acid catabolic process (GO:0009083)4.05067232
76regulation of water loss via skin (GO:0033561)4.03910555
77tryptophan metabolic process (GO:0006568)4.02650493
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.95415198
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.95175891
80L-phenylalanine catabolic process (GO:0006559)3.95175891
81fatty acid beta-oxidation (GO:0006635)3.93031558
82establishment of skin barrier (GO:0061436)3.92968078
83peptide biosynthetic process (GO:0043043)3.92064254
84NADH metabolic process (GO:0006734)3.91898416
85regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.89728731
86response to phenylpropanoid (GO:0080184)3.89698820
87oligosaccharide catabolic process (GO:0009313)3.82608912
88sodium-independent organic anion transport (GO:0043252)3.82022044
89renal tubule development (GO:0061326)3.80993537
90acetyl-CoA metabolic process (GO:0006084)3.80159673
91sulfur compound transport (GO:0072348)3.78711285
92biotin metabolic process (GO:0006768)3.76216225
93vitamin transmembrane transport (GO:0035461)3.74894024
94fatty acid oxidation (GO:0019395)3.70815797
95regulation of interleukin-5 production (GO:0032674)3.70517150
96establishment of apical/basal cell polarity (GO:0035089)3.70257493
97diterpenoid biosynthetic process (GO:0016102)3.69813491
98regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.68104410
99exocrine pancreas development (GO:0031017)3.67444721
100lipid oxidation (GO:0034440)3.62570271
101response to parathyroid hormone (GO:0071107)3.61500577
102surfactant homeostasis (GO:0043129)3.60701845
103one-carbon compound transport (GO:0019755)3.50286431
104ethanol metabolic process (GO:0006067)3.49152681
105response to growth hormone (GO:0060416)3.48798452
106serine family amino acid biosynthetic process (GO:0009070)3.47483068
107nephron epithelium development (GO:0072009)3.45997635
108response to xenobiotic stimulus (GO:0009410)3.45160180
109glutathione derivative metabolic process (GO:1901685)3.44905890
110glutathione derivative biosynthetic process (GO:1901687)3.44905890
111axoneme assembly (GO:0035082)3.44309520
112glomerular epithelial cell development (GO:0072310)3.43493990
113proline biosynthetic process (GO:0006561)3.40153684
114regulation of apoptotic process involved in morphogenesis (GO:1902337)3.39476201
115cellular amino acid catabolic process (GO:0009063)3.37789407
116water homeostasis (GO:0030104)3.37785827
117glutathione metabolic process (GO:0006749)3.33390065
118sulfur amino acid catabolic process (GO:0000098)3.32784039
119folic acid transport (GO:0015884)3.32767089
120glutamate metabolic process (GO:0006536)3.31407061
121negative regulation of keratinocyte proliferation (GO:0010839)3.31344700
122O-glycan processing (GO:0016266)3.30994076
123aromatic amino acid family metabolic process (GO:0009072)3.28621568
124kynurenine metabolic process (GO:0070189)3.28355973
125positive regulation of Cdc42 GTPase activity (GO:0043089)3.27319598
126alditol metabolic process (GO:0019400)3.26424813
127folic acid metabolic process (GO:0046655)3.26064823
128collecting duct development (GO:0072044)3.26039988
129cellular response to vitamin D (GO:0071305)3.25657379
130transepithelial transport (GO:0070633)3.25109195
131sodium ion transport (GO:0006814)3.24309037
132alpha-amino acid catabolic process (GO:1901606)3.23533034
133lung epithelium development (GO:0060428)3.22966095
134cellular ketone body metabolic process (GO:0046950)3.21815114
135calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.21182904
136epithelial cell maturation (GO:0002070)3.19919490
137fatty acid catabolic process (GO:0009062)3.19840483
138actin filament depolymerization (GO:0030042)3.18742977
139nephron epithelium morphogenesis (GO:0072088)3.16980734
140nephron tubule morphogenesis (GO:0072078)3.16980734
141negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.11237455
142regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.07882948
143lipopolysaccharide biosynthetic process (GO:0009103)3.07462819
144DNA methylation involved in gamete generation (GO:0043046)3.06040238
145notochord development (GO:0030903)3.02189268
146keratinocyte development (GO:0003334)3.01263331
147keratinization (GO:0031424)3.01205676
148retinoic acid metabolic process (GO:0042573)2.95621220
149establishment of monopolar cell polarity (GO:0061162)2.92323307
150establishment or maintenance of monopolar cell polarity (GO:0061339)2.92323307
151paraxial mesoderm development (GO:0048339)2.86036770
152positive regulation of cellular amine metabolic process (GO:0033240)2.84864034
153centriole assembly (GO:0098534)2.84730221
154regulation of integrin-mediated signaling pathway (GO:2001044)2.84460595
155nucleoside transmembrane transport (GO:1901642)2.83922777
156piRNA metabolic process (GO:0034587)2.82566498
157glycosylceramide metabolic process (GO:0006677)2.82294242
158norepinephrine metabolic process (GO:0042415)2.82005122
159heme transport (GO:0015886)2.81950337
160terpenoid biosynthetic process (GO:0016114)2.81273690
161basic amino acid transport (GO:0015802)2.80060704
162cyclooxygenase pathway (GO:0019371)2.79143842
163positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.75381989
164amyloid precursor protein catabolic process (GO:0042987)2.74398632
165protein autoprocessing (GO:0016540)2.72736491
166sphingomyelin metabolic process (GO:0006684)2.71370488
167ventricular system development (GO:0021591)2.70670387
168negative regulation of stem cell proliferation (GO:2000647)2.68786748
169microtubule bundle formation (GO:0001578)2.67218338
170cellular copper ion homeostasis (GO:0006878)2.67043682
171nucleoside transport (GO:0015858)2.66976354
172prostaglandin biosynthetic process (GO:0001516)2.66042951
173prostanoid biosynthetic process (GO:0046457)2.66042951
174regulation of keratinocyte proliferation (GO:0010837)2.64475973
175hippo signaling (GO:0035329)2.64198655
176negative regulation of T cell differentiation in thymus (GO:0033085)2.61256207
177ear development (GO:0043583)2.60908850
178* transferrin transport (GO:0033572)2.59648912
179negative regulation of glycoprotein biosynthetic process (GO:0010561)2.56140274
180regulation of clathrin-mediated endocytosis (GO:2000369)2.54845542
181COPI coating of Golgi vesicle (GO:0048205)2.54596483
182urate metabolic process (GO:0046415)10.2040764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.76208970
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.04104093
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.95871420
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.18192923
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.14005863
6* ESR1_21235772_ChIP-Seq_MCF-7_Human3.86828663
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.61047586
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.46845693
9* ESR2_21235772_ChIP-Seq_MCF-7_Human3.06552934
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.01730390
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.97543738
12AR_21909140_ChIP-Seq_LNCAP_Human2.93318630
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.87440383
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75450301
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.62409655
16ZNF263_19887448_ChIP-Seq_K562_Human2.60260544
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.58293843
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46323721
19CLOCK_20551151_ChIP-Seq_293T_Human2.29126083
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19084818
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.19028182
22AR_21572438_ChIP-Seq_LNCaP_Human2.14951229
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08408640
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.99720344
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.99433107
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.94289538
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.93190300
28GATA4_25053715_ChIP-Seq_YYC3_Human1.89212861
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86642968
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85368318
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80994590
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76050844
33RACK7_27058665_Chip-Seq_MCF-7_Human1.74614122
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.74259639
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66962265
36GATA6_25053715_ChIP-Seq_YYC3_Human1.59633520
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59263802
38KLF5_25053715_ChIP-Seq_YYC3_Human1.57326146
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.48388787
40ELF5_23300383_ChIP-Seq_T47D_Human1.47716453
41NANOG_18692474_ChIP-Seq_MEFs_Mouse1.45931642
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44918634
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44883390
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42560485
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41568461
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40636908
47VDR_22108803_ChIP-Seq_LS180_Human1.40384121
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39898487
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.39316203
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39206858
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38575379
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38247616
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37900551
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37261187
55SOX2_20726797_ChIP-Seq_SW620_Human1.36821785
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36382521
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35502851
58ATF3_27146783_Chip-Seq_COLON_Human1.34159408
59* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30422300
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30361036
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29201881
62HNF4A_19822575_ChIP-Seq_HepG2_Human1.26913712
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26242628
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25039890
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24846886
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24318647
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22750461
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21403916
69SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19791428
70LXR_22292898_ChIP-Seq_THP-1_Human1.18782491
71HOXB7_26014856_ChIP-Seq_BT474_Human1.18007752
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16794062
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16022920
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15623927
75TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.15462751
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14530799
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14384135
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.14290468
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13670478
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.12728465
81DCP1A_22483619_ChIP-Seq_HELA_Human1.11085245
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10899487
83RXR_22108803_ChIP-Seq_LS180_Human1.08768785
84* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08462520
85* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08198913
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08042431
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.06055466
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.05726167
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04431241
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02666895
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02339913
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01289162
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00790757
94CTCF_20526341_ChIP-Seq_ESCs_Human1.00508240
95TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00107664
96FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97825092
97PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97079326
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96727720
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.96466285
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96054028
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.96031157
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95672386
103STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94988310
104MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94956100
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94600460
106CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94531997
107E2F1_20622854_ChIP-Seq_HELA_Human0.93565283
108ETS1_20019798_ChIP-Seq_JURKAT_Human0.93192355
109NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92870831
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91381215
111MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91331204
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90902294
113UBF1/2_26484160_Chip-Seq_HMECs_Human0.90770621
114GABP_17652178_ChIP-ChIP_JURKAT_Human0.90032503
115P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89999979
116PHF8_20622854_ChIP-Seq_HELA_Human0.89910181
117TP63_22573176_ChIP-Seq_HFKS_Human0.88236512
118BCOR_27268052_Chip-Seq_Bcells_Human0.87421734
119* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87375873
120SMC4_20622854_ChIP-Seq_HELA_Human0.87271372
121CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87223331
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.86683560
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86525337
124* TBX20_22080862_ChIP-Seq_HEART_Mouse0.85931701
125* TBX20_22328084_ChIP-Seq_HEART_Mouse0.85931701
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83874557
127EGR1_19032775_ChIP-ChIP_M12_Human0.83835992
128P68_20966046_ChIP-Seq_HELA_Human0.83591594
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83576376
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.83241531
131AHR_22903824_ChIP-Seq_MCF-7_Human0.83119116
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83040206
133RAC3_21632823_ChIP-Seq_H3396_Human0.82358079
134NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82176929
135GATA3_21867929_ChIP-Seq_CD8_Mouse0.82118973
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81977920
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81434927
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80985374
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80985374
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80880946
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78451200
142TP63_23658742_ChIP-Seq_EP156T_Human0.77245079
143NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77118952
144CDX2_22108803_ChIP-Seq_LS180_Human0.76847085
145SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76260908
146NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.75089898
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73646336
148CEBPB_22108803_ChIP-Seq_LS180_Human0.73367393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.51261775
2MP0004043_abnormal_pH_regulation6.37198569
3MP0004019_abnormal_vitamin_homeostasis5.16933065
4MP0005332_abnormal_amino_acid4.42235439
5MP0003195_calcinosis4.34909194
6MP0009643_abnormal_urine_homeostasis3.87293356
7MP0001765_abnormal_ion_homeostasis3.77379266
8MP0003136_yellow_coat_color3.66945965
9MP0002139_abnormal_hepatobiliary_system3.55138769
10MP0001756_abnormal_urination3.51906328
11MP0002138_abnormal_hepatobiliary_system3.50720557
12MP0004381_abnormal_hair_follicle3.45433382
13MP0005171_absent_coat_pigmentation3.38882709
14MP0005377_hearing/vestibular/ear_phenot3.24337804
15MP0003878_abnormal_ear_physiology3.24337804
16MP0005636_abnormal_mineral_homeostasis3.05089088
17MP0002136_abnormal_kidney_physiology3.04353158
18MP0000383_abnormal_hair_follicle2.88602466
19MP0010234_abnormal_vibrissa_follicle2.74172601
20MP0008875_abnormal_xenobiotic_pharmacok2.69977349
21MP0002653_abnormal_ependyma_morphology2.66840942
22MP0001958_emphysema2.61162909
23MP0002796_impaired_skin_barrier2.59424931
24MP0000647_abnormal_sebaceous_gland2.54987819
25MP0003950_abnormal_plasma_membrane2.53649882
26MP0002837_dystrophic_cardiac_calcinosis2.24281514
27MP0010352_gastrointestinal_tract_polyps1.95282602
28MP0003890_abnormal_embryonic-extraembry1.95244969
29MP0005451_abnormal_body_composition1.86086222
30MP0003252_abnormal_bile_duct1.84580461
31MP0004885_abnormal_endolymph1.78352540
32MP0003186_abnormal_redox_activity1.75331690
33MP0000427_abnormal_hair_cycle1.74454000
34MP0005365_abnormal_bile_salt1.70124517
35MP0005075_abnormal_melanosome_morpholog1.68812010
36MP0005501_abnormal_skin_physiology1.68296577
37MP0000538_abnormal_urinary_bladder1.67819003
38MP0005058_abnormal_lysosome_morphology1.62491797
39MP0005085_abnormal_gallbladder_physiolo1.57224896
40MP0001346_abnormal_lacrimal_gland1.57177279
41MP0008961_abnormal_basal_metabolism1.48665374
42MP0002168_other_aberrant_phenotype1.48344053
43MP0004233_abnormal_muscle_weight1.35508379
44MP0002098_abnormal_vibrissa_morphology1.32678344
45MP0005275_abnormal_skin_tensile1.32574145
46MP0002876_abnormal_thyroid_physiology1.31346504
47MP0004264_abnormal_extraembryonic_tissu1.30837383
48MP0001348_abnormal_lacrimal_gland1.21063574
49MP0005395_other_phenotype1.19437763
50MP0000566_synostosis1.18912918
51MP0002135_abnormal_kidney_morphology1.14936772
52MP0003300_gastrointestinal_ulcer1.14017206
53MP0005584_abnormal_enzyme/coenzyme_acti1.13279995
54MP0003045_fibrosis1.08501149
55MP0005319_abnormal_enzyme/_coenzyme1.08442138
56MP0008872_abnormal_physiological_respon1.06708590
57MP0000230_abnormal_systemic_arterial1.06355521
58MP0005670_abnormal_white_adipose1.05584839
59MP0003879_abnormal_hair_cell1.04202090
60MP0003941_abnormal_skin_development1.03517514
61MP0005409_darkened_coat_color1.03024086
62MP0009379_abnormal_foot_pigmentation1.01495521
63MP0002896_abnormal_bone_mineralization1.00840067
64MP0000377_abnormal_hair_follicle0.98628153
65MP0004957_abnormal_blastocyst_morpholog0.96695581
66MP0009780_abnormal_chondrocyte_physiolo0.96600283
67MP0003191_abnormal_cellular_cholesterol0.93911764
68MP0003566_abnormal_cell_adhesion0.92424005
69MP0001216_abnormal_epidermal_layer0.88972894
70MP0000358_abnormal_cell_content/0.88852642
71MP0005666_abnormal_adipose_tissue0.88705498
72MP0003806_abnormal_nucleotide_metabolis0.87447370
73MP0008004_abnormal_stomach_pH0.86609897
74MP0006036_abnormal_mitochondrial_physio0.85362358
75MP0004272_abnormal_basement_membrane0.81915392
76MP0000372_irregular_coat_pigmentation0.80672847
77MP0002928_abnormal_bile_duct0.80078158
78MP0001661_extended_life_span0.77380742
79MP0003718_maternal_effect0.75972752
80MP0001764_abnormal_homeostasis0.75767498
81MP0003315_abnormal_perineum_morphology0.75234365
82MP0010678_abnormal_skin_adnexa0.74161561
83MP0003638_abnormal_response/metabolism_0.73434661
84MP0005084_abnormal_gallbladder_morpholo0.72521935
85MP0001666_abnormal_nutrient_absorption0.71712848
86MP0002075_abnormal_coat/hair_pigmentati0.70875467
87MP0000762_abnormal_tongue_morphology0.70824627
88MP0002095_abnormal_skin_pigmentation0.70241686
89MP0003646_muscle_fatigue0.69895654
90MP0002089_abnormal_postnatal_growth/wei0.69665155
91MP0002118_abnormal_lipid_homeostasis0.67628319
92MP0002160_abnormal_reproductive_system0.67339876
93MP0000534_abnormal_ureter_morphology0.66676515
94MP0000015_abnormal_ear_pigmentation0.65855351
95MP0000470_abnormal_stomach_morphology0.65136295
96MP0005535_abnormal_body_temperature0.64565872
97MP0005083_abnormal_biliary_tract0.64222488
98MP0000749_muscle_degeneration0.62789583
99MP0003705_abnormal_hypodermis_morpholog0.62787414
100MP0010771_integument_phenotype0.61100690
101MP0005330_cardiomyopathy0.60801665
102MP0003329_amyloid_beta_deposits0.60433985
103MP0005408_hypopigmentation0.60188249
104MP0005076_abnormal_cell_differentiation0.60031716
105MP0003283_abnormal_digestive_organ0.58506895
106MP0001186_pigmentation_phenotype0.58432453
107MP0003693_abnormal_embryo_hatching0.58302180
108MP0000579_abnormal_nail_morphology0.57797836
109MP0005220_abnormal_exocrine_pancreas0.57684535
110MP0009642_abnormal_blood_homeostasis0.57273191
111MP0008932_abnormal_embryonic_tissue0.56650599
112MP0008789_abnormal_olfactory_epithelium0.56228110
113MP0009764_decreased_sensitivity_to0.55400272
114MP0002084_abnormal_developmental_patter0.54764042
115MP0002115_abnormal_skeleton_extremities0.54728929
116MP0000367_abnormal_coat/_hair0.53986385
117MP0002060_abnormal_skin_morphology0.53742846
118MP0001485_abnormal_pinna_reflex0.52621675
119MP0001697_abnormal_embryo_size0.52356375
120MP0003453_abnormal_keratinocyte_physiol0.52336391
121MP0005257_abnormal_intraocular_pressure0.50163986
122MP0000609_abnormal_liver_physiology0.49905804
123MP0005165_increased_susceptibility_to0.49832245
124MP0001849_ear_inflammation0.49469542
125MP0004742_abnormal_vestibular_system0.49078120
126MP0001243_abnormal_dermal_layer0.47813499
127MP0003795_abnormal_bone_structure0.47664087
128MP0005623_abnormal_meninges_morphology0.46685554
129MP0008260_abnormal_autophagy0.46168077
130MP0001191_abnormal_skin_condition0.45743327
131MP0002254_reproductive_system_inflammat0.45473175
132MP0000163_abnormal_cartilage_morphology0.44795522
133MP0001730_embryonic_growth_arrest0.44552924
134MP0000747_muscle_weakness0.44256708
135MP0005375_adipose_tissue_phenotype0.41122333
136MP0010329_abnormal_lipoprotein_level0.39792894
137MP0000678_abnormal_parathyroid_gland0.38639878
138MP0001177_atelectasis0.38312286
139MP0006035_abnormal_mitochondrial_morpho0.38003460
140MP0004484_altered_response_of0.37282850
141MP0004782_abnormal_surfactant_physiolog0.36108215
142MP0002282_abnormal_trachea_morphology0.35915671
143MP0004147_increased_porphyrin_level0.35494139
144MP0000467_abnormal_esophagus_morphology0.34634089
145MP0000598_abnormal_liver_morphology0.33014658
146MP0002998_abnormal_bone_remodeling0.32675466

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)8.20479905
2Hypokalemic alkalosis (HP:0001949)7.91618953
3Metabolic alkalosis (HP:0200114)7.85183883
4Hyperactive renin-angiotensin system (HP:0000841)7.33980173
5Hypomagnesemia (HP:0002917)7.18914581
6Gout (HP:0001997)7.03500934
7Polyuria (HP:0000103)6.79699015
8Abnormality of chloride homeostasis (HP:0011422)6.75828637
9Abnormal urine output (HP:0012590)6.34796763
10Abnormality of magnesium homeostasis (HP:0004921)6.04431511
11Abnormality of renal excretion (HP:0011036)6.02472738
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.66747021
13Abnormal drinking behavior (HP:0030082)5.39451961
14Polydipsia (HP:0001959)5.39451961
15Renal salt wasting (HP:0000127)5.35555795
16Tetany (HP:0001281)5.32543390
17Proximal tubulopathy (HP:0000114)5.14966098
18Hyperaldosteronism (HP:0000859)5.11680487
19Abnormality of renin-angiotensin system (HP:0000847)5.06548076
20Amelogenesis imperfecta (HP:0000705)5.05132974
21Alkalosis (HP:0001948)4.94393414
22Hyperuricemia (HP:0002149)4.93320192
23Increased purine levels (HP:0004368)4.93320192
24Abnormal respiratory motile cilium physiology (HP:0012261)4.87449664
25Abnormal respiratory epithelium morphology (HP:0012253)4.82492465
26Abnormal respiratory motile cilium morphology (HP:0005938)4.82492465
27Hyperglycinuria (HP:0003108)4.82449549
28Dynein arm defect of respiratory motile cilia (HP:0012255)4.71309550
29Absent/shortened dynein arms (HP:0200106)4.71309550
30Abnormal ciliary motility (HP:0012262)4.63446924
31Chronic bronchitis (HP:0004469)4.47628782
32Rhinitis (HP:0012384)4.36768994
33Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25220863
34Abnormality of purine metabolism (HP:0004352)4.11687666
35Hypokalemia (HP:0002900)3.94806406
36Hypercalciuria (HP:0002150)3.92475333
37Abnormality of glycine metabolism (HP:0010895)3.84076296
38Abnormality of serine family amino acid metabolism (HP:0010894)3.84076296
39Generalized aminoaciduria (HP:0002909)3.75494617
40Glycosuria (HP:0003076)3.38708590
41Abnormality of urine glucose concentration (HP:0011016)3.38708590
42Delayed epiphyseal ossification (HP:0002663)3.29129374
43Bronchiectasis (HP:0002110)3.28248495
44Abnormality of potassium homeostasis (HP:0011042)3.23911521
45Abnormality of nucleobase metabolism (HP:0010932)3.04244094
46Ketoacidosis (HP:0001993)2.97746728
47Hyperphosphaturia (HP:0003109)2.89896661
48Abnormality of proline metabolism (HP:0010907)2.84757638
49Hydroxyprolinuria (HP:0003080)2.84757638
50Hyperglycinemia (HP:0002154)2.81008670
51Abnormality of fatty-acid metabolism (HP:0004359)2.74156965
52Abnormal urine phosphate concentration (HP:0012599)2.73008869
53Woolly hair (HP:0002224)2.72494694
54Nephrolithiasis (HP:0000787)2.69030857
55Fragile nails (HP:0001808)2.68151196
56* Renal tubular acidosis (HP:0001947)2.66876219
57Abnormality of sodium homeostasis (HP:0010931)2.64882708
58Metaphyseal cupping (HP:0003021)2.55663807
59Ketosis (HP:0001946)2.55283871
60Hyponatremia (HP:0002902)2.52589993
61Congenital ichthyosiform erythroderma (HP:0007431)2.52458909
62Nasal polyposis (HP:0100582)2.52442996
63Vascular calcification (HP:0004934)2.46566827
64* Dehydration (HP:0001944)2.45881203
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.45528126
66Rickets (HP:0002748)2.44978361
67Pili torti (HP:0003777)2.42120315
68* Nephrocalcinosis (HP:0000121)2.41530181
69Widely patent fontanelles and sutures (HP:0004492)2.38115374
70Vacuolated lymphocytes (HP:0001922)2.35016155
71Facial shape deformation (HP:0011334)2.34768870
72Potter facies (HP:0002009)2.34768870
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34098523
74Malnutrition (HP:0004395)2.32430014
75Paralysis (HP:0003470)2.30860324
76Chondrocalcinosis (HP:0000934)2.29997154
77Adrenal overactivity (HP:0002717)2.28705094
78Hypophosphatemia (HP:0002148)2.25871583
79Delayed CNS myelination (HP:0002188)2.25122458
80Tubulointerstitial fibrosis (HP:0005576)2.21158230
81Cardiovascular calcification (HP:0011915)2.21110998
82Abnormality of the dental root (HP:0006486)2.17968697
83Taurodontia (HP:0000679)2.17968697
84Abnormality of permanent molar morphology (HP:0011071)2.17968697
85Abnormality of Sharpey fibers (HP:0100685)2.15730810
86Male infertility (HP:0003251)2.15454992
87Hyperammonemia (HP:0001987)2.12989340
88Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10282489
89Right ventricular cardiomyopathy (HP:0011663)2.06937182
90Dicarboxylic aciduria (HP:0003215)2.05805737
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05805737
92Abnormality of renal resorption (HP:0011038)2.02518172
93Confusion (HP:0001289)2.01031099
94Bicornuate uterus (HP:0000813)2.00974345
95Abnormality of molar morphology (HP:0011070)1.99543138
96Abnormality of molar (HP:0011077)1.99543138
97Tubular atrophy (HP:0000092)1.99449832
98Abnormal enzyme/coenzyme activity (HP:0012379)1.95531125
99Thin bony cortex (HP:0002753)1.95159756
100Enlarged kidneys (HP:0000105)1.92775980
101Abnormality of the nasal mucosa (HP:0000433)1.92304716
102Abnormality of alkaline phosphatase activity (HP:0004379)1.90505825
103Abnormal tarsal ossification (HP:0008369)1.88613510
104Abnormality of the dental pulp (HP:0006479)1.88407238
105Metabolic acidosis (HP:0001942)1.88034472
106* Vomiting (HP:0002013)1.87253059
107Abnormality of the frontal sinuses (HP:0002687)1.86719222
108Lethargy (HP:0001254)1.86073676
109Infertility (HP:0000789)1.86067417
110Metaphyseal irregularity (HP:0003025)1.85864235
111Decreased circulating renin level (HP:0003351)1.85824330
112Abnormality of the costochondral junction (HP:0000919)1.85191826
113Glomerulosclerosis (HP:0000096)1.82043069
114Aplasia of the musculature (HP:0100854)1.80716185
115Hypotension (HP:0002615)1.79781203
116Lip pit (HP:0100267)1.78397561
117Nausea (HP:0002018)1.75976777
118Abnormality of sulfur amino acid metabolism (HP:0004339)1.74366226
119Onycholysis (HP:0001806)1.74330989
120Popliteal pterygium (HP:0009756)1.73924345
121Erythroderma (HP:0001019)1.71465120
122Aplasia/Hypoplasia of the spleen (HP:0010451)1.68937592
123Irritability (HP:0000737)1.66561259
124Methylmalonic aciduria (HP:0012120)1.66524169
125Bronchitis (HP:0012387)1.64563727
126Cone-rod dystrophy (HP:0000548)1.63830636
127Advanced eruption of teeth (HP:0006288)1.63742286
128Generalized muscle weakness (HP:0003324)1.63677117
129Abnormality of serum amino acid levels (HP:0003112)1.62730535
130* Renal tubular dysfunction (HP:0000124)1.61968149
131Pancreatic cysts (HP:0001737)1.60371795
132Abnormality of macular pigmentation (HP:0008002)1.59745743
133Abnormality of dental color (HP:0011073)1.59269849
134Asplenia (HP:0001746)1.57582799
135Distal lower limb muscle weakness (HP:0009053)1.57283348
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57128556
137Protuberant abdomen (HP:0001538)1.56483382
138Recurrent otitis media (HP:0000403)1.56003398
139Abnormality of aromatic amino acid family metabolism (HP:0004338)1.55467279
140Enlarged epiphyses (HP:0010580)1.51705881
141High anterior hairline (HP:0009890)1.50608030
142Hypoplasia of dental enamel (HP:0006297)1.49350791
143Abnormality of carpal bone ossification (HP:0006257)1.47869680
144Hypoparathyroidism (HP:0000829)1.47194408
145Hypotrichosis (HP:0001006)1.45861921
146Ulnar bowing (HP:0003031)1.44384200
147Lymphangioma (HP:0100764)1.42304113
148Abnormal hair laboratory examination (HP:0003328)1.42013495
149Elevated alkaline phosphatase (HP:0003155)1.41807752
150Parakeratosis (HP:0001036)1.41802122
151Abnormality of the renal medulla (HP:0100957)1.41689573
152Recurrent sinusitis (HP:0011108)1.41443372
153Thick nail (HP:0001805)1.41125332
154Hyperkalemia (HP:0002153)1.40157790
155Occipital encephalocele (HP:0002085)1.39313008
156Cystic liver disease (HP:0006706)1.38615367
157Cerebellar dysplasia (HP:0007033)1.37014586
158Hypokinesia (HP:0002375)1.35622786
159Brittle hair (HP:0002299)1.33592948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.39878919
2WNK37.95487163
3OXSR17.15820461
4STK394.26290476
5STK38L2.95528210
6BCKDK2.43975573
7NEK12.09512319
8EPHA22.07909104
9MST41.97090002
10PDK31.93982498
11PDK41.93982498
12PDK21.65765666
13SGK2231.60633429
14SGK4941.60633429
15MST1R1.54207835
16MAPK151.49504526
17WNK11.43336744
18STK381.34131988
19MAP3K31.19181959
20PINK11.16850126
21LRRK21.16037828
22FER1.13112551
23FGFR41.07962660
24CDK121.06038672
25LATS11.03794879
26EPHB11.02207569
27SGK20.92742275
28PRKD30.87009668
29SGK30.86134310
30IRAK30.85583335
31ICK0.84790217
32NME10.84082004
33PRKCI0.80552103
34NEK60.78079726
35SCYL20.78064121
36STK100.76803793
37LMTK20.75105649
38BMPR1B0.70933386
39PAK40.70923416
40GSK3A0.67661410
41TESK10.67582684
42TTK0.67347109
43NME20.62996211
44PRKG20.60970234
45PTK20.60303705
46MAP3K60.59453385
47DYRK1B0.58640437
48ERN10.55982495
49ABL20.53716324
50STK160.51187134
51TGFBR20.50213140
52MET0.49943768
53PLK10.49302723
54MAPKAPK30.47729879
55SMG10.45372463
56GRK60.44715336
57LATS20.44657391
58PRKAA10.44325044
59CHEK20.43508197
60ARAF0.42933033
61EPHB20.41689455
62MELK0.40776243
63EPHA30.40065126
64SGK10.40042855
65TRIB30.39952341
66NLK0.38172596
67MAP2K70.37942892
68BUB10.37673540
69TIE10.37164355
70PAK30.37005755
71PTK60.36202704
72EIF2AK10.36086328
73MAP3K70.33855742
74EIF2AK30.33491717
75AKT30.33233197
76STK240.32967744
77STK30.32121523
78PRKD20.30336054
79MAP3K90.29579262
80ACVR1B0.29508996
81PNCK0.26996172
82PDPK10.26816245
83LIMK10.26585816
84MAPK110.26435798
85MAP3K20.25880249
86ILK0.25876017
87MAP2K10.25507481
88PRKCZ0.25024394
89RPS6KB20.24718210
90IRAK10.23687938
91PRKAA20.23073076
92TAOK10.22473671
93PTK2B0.21856523
94CDK70.21294397
95CAMK2G0.20383680
96AKT20.20182370
97TSSK60.19763303
98PRKCD0.19378921
99MAP3K80.18877460
100MAP2K20.18860026
101PIM10.18353056
102TNIK0.18038916
103PAK10.16971900
104ERBB40.16488997
105PHKG10.16256249
106PHKG20.16256249
107CDK190.16192810
108DDR20.15832377
109MTOR0.15570862
110VRK20.15110152
111AURKA0.14184432
112CHEK10.13712023
113PLK40.12792815
114WEE10.12467160
115ADRBK10.11996273
116PRKD10.11278460
117BMX0.11028581
118MAP3K120.10594390
119STK40.10577635
120FRK0.10488886
121MYLK0.09595235
122PRKCA0.09125628
123BCR0.08232700
124IRAK20.07667686
125PRKACG0.07547298
126PRKACA0.07182314
127DYRK30.06966887
128PLK20.06559615
129ZAK0.06457712
130CAMK2B0.06419814
131CSNK1E0.06357745
132EEF2K0.06351920
133STK110.06188459
134CSNK1A10.06029375
135ROCK10.05657711
136PBK0.05340571
137NEK20.05336667
138TGFBR10.05304219
139NTRK10.04943189
140NEK90.03213440
141RIPK10.02777349
142PRKCE0.02750948
143AURKB0.02489997
144MATK0.00894362
145ERBB20.00103777
146MAP3K11-0.0001451

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.87622832
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.43958568
3Butanoate metabolism_Homo sapiens_hsa006503.40482095
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.26057200
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22488691
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.08669383
7Pentose and glucuronate interconversions_Homo sapiens_hsa000403.07540858
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.05503506
9Propanoate metabolism_Homo sapiens_hsa006402.92930101
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.86823551
11Vitamin digestion and absorption_Homo sapiens_hsa049772.53004193
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.32078079
13Peroxisome_Homo sapiens_hsa041462.28945126
14Fatty acid degradation_Homo sapiens_hsa000712.26508468
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.25787714
16Pyruvate metabolism_Homo sapiens_hsa006202.15222111
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12096683
18beta-Alanine metabolism_Homo sapiens_hsa004102.00538024
19Tryptophan metabolism_Homo sapiens_hsa003801.99626072
20Glutathione metabolism_Homo sapiens_hsa004801.88486079
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87530350
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82532959
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82277713
24* Collecting duct acid secretion_Homo sapiens_hsa049661.77862032
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74557555
26Carbon metabolism_Homo sapiens_hsa012001.68125701
27Mineral absorption_Homo sapiens_hsa049781.68055348
28Sulfur metabolism_Homo sapiens_hsa009201.67591948
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60834332
30Fatty acid metabolism_Homo sapiens_hsa012121.60180419
31* Vibrio cholerae infection_Homo sapiens_hsa051101.57116590
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54134698
33Bile secretion_Homo sapiens_hsa049761.53233220
34Protein digestion and absorption_Homo sapiens_hsa049741.49428695
35Other glycan degradation_Homo sapiens_hsa005111.47309644
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47139856
37Folate biosynthesis_Homo sapiens_hsa007901.45909520
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44967346
39Arginine and proline metabolism_Homo sapiens_hsa003301.43999797
40Basal transcription factors_Homo sapiens_hsa030221.42193394
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24467955
42Phototransduction_Homo sapiens_hsa047441.23004474
43Histidine metabolism_Homo sapiens_hsa003401.18784946
44Huntingtons disease_Homo sapiens_hsa050161.18511418
45Ribosome_Homo sapiens_hsa030101.18166056
46PPAR signaling pathway_Homo sapiens_hsa033201.17654351
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15916853
48Lysine degradation_Homo sapiens_hsa003101.10104035
49Biosynthesis of amino acids_Homo sapiens_hsa012301.09218126
50Adherens junction_Homo sapiens_hsa045201.08227712
51Selenocompound metabolism_Homo sapiens_hsa004501.07062053
52Phenylalanine metabolism_Homo sapiens_hsa003601.06339585
53Fructose and mannose metabolism_Homo sapiens_hsa000511.05474248
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03541133
55Starch and sucrose metabolism_Homo sapiens_hsa005001.01041698
56RNA transport_Homo sapiens_hsa030130.99917275
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99768100
58Glycerolipid metabolism_Homo sapiens_hsa005610.98585271
59Arginine biosynthesis_Homo sapiens_hsa002200.98372103
60Pentose phosphate pathway_Homo sapiens_hsa000300.94247525
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92921000
62* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92883090
63Thyroid cancer_Homo sapiens_hsa052160.92879890
64N-Glycan biosynthesis_Homo sapiens_hsa005100.89801084
65Renin-angiotensin system_Homo sapiens_hsa046140.86558581
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85686482
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85326258
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84556233
69Chemical carcinogenesis_Homo sapiens_hsa052040.80829559
70Retinol metabolism_Homo sapiens_hsa008300.79588991
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.78682959
72Proteasome_Homo sapiens_hsa030500.78526043
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.76303426
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76095722
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.75057237
76* Synaptic vesicle cycle_Homo sapiens_hsa047210.70711396
77Arachidonic acid metabolism_Homo sapiens_hsa005900.70275738
78Nitrogen metabolism_Homo sapiens_hsa009100.70012396
79Nucleotide excision repair_Homo sapiens_hsa034200.68051708
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.66568735
81Olfactory transduction_Homo sapiens_hsa047400.62973720
82* Lysosome_Homo sapiens_hsa041420.60294989
83Fatty acid elongation_Homo sapiens_hsa000620.59617253
84* Metabolic pathways_Homo sapiens_hsa011000.59003360
85mRNA surveillance pathway_Homo sapiens_hsa030150.56973229
86Sphingolipid metabolism_Homo sapiens_hsa006000.56733208
87Fatty acid biosynthesis_Homo sapiens_hsa000610.56299160
88Pancreatic cancer_Homo sapiens_hsa052120.54261970
89Vitamin B6 metabolism_Homo sapiens_hsa007500.53575881
90Endocytosis_Homo sapiens_hsa041440.52752891
91Thyroid hormone synthesis_Homo sapiens_hsa049180.52302499
92Gastric acid secretion_Homo sapiens_hsa049710.48132953
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44775399
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.43401053
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43208608
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43115846
97* Oxidative phosphorylation_Homo sapiens_hsa001900.41618561
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41294051
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41130124
100Pyrimidine metabolism_Homo sapiens_hsa002400.40975218
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.37767675
102Tyrosine metabolism_Homo sapiens_hsa003500.37199695
103Endometrial cancer_Homo sapiens_hsa052130.37078559
104Sulfur relay system_Homo sapiens_hsa041220.35851438
105Taste transduction_Homo sapiens_hsa047420.35036722
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33590694
107ECM-receptor interaction_Homo sapiens_hsa045120.33091662
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.30962252
109Regulation of autophagy_Homo sapiens_hsa041400.30072354
110Steroid biosynthesis_Homo sapiens_hsa001000.29651071
111Small cell lung cancer_Homo sapiens_hsa052220.28394460
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28354230
113Base excision repair_Homo sapiens_hsa034100.28037676
114Galactose metabolism_Homo sapiens_hsa000520.25085274
115Tight junction_Homo sapiens_hsa045300.24871052
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23463052
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21891634
118ABC transporters_Homo sapiens_hsa020100.18271021
119Parkinsons disease_Homo sapiens_hsa050120.14871933
120Bladder cancer_Homo sapiens_hsa052190.14442787
121Choline metabolism in cancer_Homo sapiens_hsa052310.14281101
122Hedgehog signaling pathway_Homo sapiens_hsa043400.08042125
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.08004900
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06820215
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.06800104
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06556704
127Insulin resistance_Homo sapiens_hsa049310.06286636
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.05687527
129Inositol phosphate metabolism_Homo sapiens_hsa005620.05640909
130FoxO signaling pathway_Homo sapiens_hsa040680.04745611
131AMPK signaling pathway_Homo sapiens_hsa041520.02329380
132Hepatitis C_Homo sapiens_hsa051600.00286203
133One carbon pool by folate_Homo sapiens_hsa00670-0.0065193
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0063362
135Hippo signaling pathway_Homo sapiens_hsa04390-0.0016746

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