ATP6V0B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1amino sugar catabolic process (GO:0046348)4.57473202
2* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.43307442
3* ATP hydrolysis coupled proton transport (GO:0015991)4.43307442
4* transferrin transport (GO:0033572)4.37028105
5* phagosome maturation (GO:0090382)4.33718052
6neuron cell-cell adhesion (GO:0007158)4.30479438
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.23282385
8N-acetylneuraminate metabolic process (GO:0006054)4.20186603
9synaptic vesicle exocytosis (GO:0016079)4.05365444
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.04886841
11* trivalent inorganic cation transport (GO:0072512)4.03253346
12* ferric iron transport (GO:0015682)4.03253346
13presynaptic membrane assembly (GO:0097105)3.83960108
14long-chain fatty acid biosynthetic process (GO:0042759)3.74555201
15neuronal action potential propagation (GO:0019227)3.67893105
16presynaptic membrane organization (GO:0097090)3.64683627
17negative regulation of neurotransmitter transport (GO:0051589)3.59639304
18chaperone-mediated protein transport (GO:0072321)3.57268492
19purine deoxyribonucleotide catabolic process (GO:0009155)3.53974718
20cytochrome complex assembly (GO:0017004)3.50776446
21respiratory chain complex IV assembly (GO:0008535)3.46817613
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38954258
23proteasome assembly (GO:0043248)3.34893239
24dopamine biosynthetic process (GO:0042416)3.32038017
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.31999697
26regulation of synaptic vesicle exocytosis (GO:2000300)3.30133482
27reactive oxygen species biosynthetic process (GO:1903409)3.29868522
28ATP synthesis coupled proton transport (GO:0015986)3.28786891
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28786891
30axon ensheathment in central nervous system (GO:0032291)3.27990068
31central nervous system myelination (GO:0022010)3.27990068
32protein neddylation (GO:0045116)3.27914953
33fatty acid elongation (GO:0030497)3.27516370
34respiratory electron transport chain (GO:0022904)3.26229641
35cellular extravasation (GO:0045123)3.25032055
36response to peptidoglycan (GO:0032494)3.21145846
37base-excision repair, AP site formation (GO:0006285)3.19790845
38electron transport chain (GO:0022900)3.19735597
39oligosaccharide catabolic process (GO:0009313)3.17676908
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17584376
41glycosphingolipid catabolic process (GO:0046479)3.16118066
42regulation of glutamate secretion (GO:0014048)3.10364838
43neutrophil mediated immunity (GO:0002446)3.09600910
44negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.09284438
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.06939392
46antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.06756577
47vocalization behavior (GO:0071625)3.05423371
48negative regulation of neurotransmitter secretion (GO:0046929)3.04687829
49glutamate secretion (GO:0014047)3.04386015
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00759827
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99247789
52positive regulation of TOR signaling (GO:0032008)2.98204767
53pH reduction (GO:0045851)2.97364255
54mitochondrial respiratory chain complex assembly (GO:0033108)2.95025971
55regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93194320
56protein localization to synapse (GO:0035418)2.93159965
57glycolipid catabolic process (GO:0019377)2.93059017
58dopamine transport (GO:0015872)2.91669441
59negative regulation of amino acid transport (GO:0051956)2.91201739
60protoporphyrinogen IX biosynthetic process (GO:0006782)2.91066446
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89767262
62purine deoxyribonucleotide metabolic process (GO:0009151)2.89256795
63neuron-neuron synaptic transmission (GO:0007270)2.89222103
64protein maturation by protein folding (GO:0022417)2.88359449
65neutrophil activation involved in immune response (GO:0002283)2.88124137
66regulation of catecholamine metabolic process (GO:0042069)2.87325779
67regulation of dopamine metabolic process (GO:0042053)2.87325779
68DNA deamination (GO:0045006)2.87312807
69intracellular pH reduction (GO:0051452)2.86568284
70negative regulation of interleukin-12 production (GO:0032695)2.85864550
71regulation of synaptic vesicle transport (GO:1902803)2.85558279
72synaptic transmission, dopaminergic (GO:0001963)2.84868968
73regulation of cellular amino acid metabolic process (GO:0006521)2.84059363
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.83433589
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.83266398
76NADH dehydrogenase complex assembly (GO:0010257)2.83266398
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83266398
78* hydrogen ion transmembrane transport (GO:1902600)2.82283801
79regulation of mitochondrial translation (GO:0070129)2.80339804
80positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79675108
81immunoglobulin mediated immune response (GO:0016064)2.79279770
82microglial cell activation (GO:0001774)2.77743578
83sphingolipid catabolic process (GO:0030149)2.75894034
84establishment of protein localization to mitochondrial membrane (GO:0090151)2.75168851
85transmission of nerve impulse (GO:0019226)2.72978810
86hydrogen peroxide biosynthetic process (GO:0050665)2.71350678
87* iron ion transport (GO:0006826)2.70325087
88regulation of chemokine biosynthetic process (GO:0045073)2.69830288
89positive regulation of chemokine biosynthetic process (GO:0045080)2.69203317
90ceramide catabolic process (GO:0046514)2.69080616
91membrane lipid catabolic process (GO:0046466)2.68027682
92protein deneddylation (GO:0000338)2.68001044
93glutamate receptor signaling pathway (GO:0007215)2.66639156
94synaptic transmission, glutamatergic (GO:0035249)2.66529912
95* proton transport (GO:0015992)2.65527061
96substantia nigra development (GO:0021762)2.65044334
97pyrimidine-containing compound salvage (GO:0008655)2.63034886
98pyrimidine nucleoside salvage (GO:0043097)2.63034886
99behavioral response to cocaine (GO:0048148)2.62594092
100positive regulation of prostaglandin secretion (GO:0032308)2.61764806
101* hydrogen transport (GO:0006818)2.61343253
102adult walking behavior (GO:0007628)2.60614365
103positive regulation of action potential (GO:0045760)2.60471630
104regulation of vesicle fusion (GO:0031338)2.59961013
105mating behavior (GO:0007617)2.59126247
106regulation of glutamate receptor signaling pathway (GO:1900449)2.58623351
107heme biosynthetic process (GO:0006783)2.57805198
108GDP-mannose metabolic process (GO:0019673)2.57792683
109regulation of voltage-gated calcium channel activity (GO:1901385)2.56460477
110long-term synaptic potentiation (GO:0060291)2.55772736
111deoxyribonucleotide catabolic process (GO:0009264)2.55683706
112protein complex biogenesis (GO:0070271)2.54462937
113neurotransmitter secretion (GO:0007269)2.54203700
114negative regulation of growth of symbiont in host (GO:0044130)2.54156760
115negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.54156760
116modulation of growth of symbiont involved in interaction with host (GO:0044144)2.54156760
117regulation of growth of symbiont in host (GO:0044126)2.54156760
118positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52715959
119startle response (GO:0001964)2.51727739
120macrophage activation (GO:0042116)2.51617694
121eosinophil chemotaxis (GO:0048245)2.51388972
122protein targeting to mitochondrion (GO:0006626)2.50842701
123postsynaptic membrane organization (GO:0001941)2.50696793
124response to cocaine (GO:0042220)2.48558232
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48533395
126synaptic vesicle transport (GO:0048489)2.47926535
127establishment of synaptic vesicle localization (GO:0097480)2.47926535
128cellular response to cadmium ion (GO:0071276)2.47679689
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47512453
130myeloid leukocyte mediated immunity (GO:0002444)2.46738271
131heme metabolic process (GO:0042168)2.46537938
132mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.45888440
133establishment of protein localization to mitochondrion (GO:0072655)2.45397577
134mannosylation (GO:0097502)2.45335015
135negative regulation of amine transport (GO:0051953)2.45252280
136antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.45004838
137neurotransmitter uptake (GO:0001504)2.44573219
138regulation of amino acid transport (GO:0051955)2.44025114
139macrophage activation involved in immune response (GO:0002281)2.43254811
140neuron recognition (GO:0008038)2.43053030
141neurotransmitter transport (GO:0006836)2.42645591
142C-terminal protein lipidation (GO:0006501)2.42404065
143protein localization to cilium (GO:0061512)2.41953271
144deoxyribose phosphate catabolic process (GO:0046386)2.39445120
145response to histamine (GO:0034776)2.38762207
146cellular response to zinc ion (GO:0071294)2.38655022
147positive regulation of membrane potential (GO:0045838)2.38399171
148negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.38336133
149regulation of neurotransmitter secretion (GO:0046928)2.37615368
150positive regulation of synapse assembly (GO:0051965)2.37271358
151cerebellar granule cell differentiation (GO:0021707)2.36234591
152positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.36228554
153regulation of axon regeneration (GO:0048679)2.35985346
154regulation of neuron projection regeneration (GO:0070570)2.35985346
155intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.35072474
156signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.35072474
157ATP biosynthetic process (GO:0006754)2.34816346
158granulocyte activation (GO:0036230)2.34639877
159regulation of superoxide anion generation (GO:0032928)2.34424339
160response to redox state (GO:0051775)2.34363268
161modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.33433155
162positive regulation by organism of defense response of other organism involved in symbiotic interact2.33433155
163modulation by symbiont of host immune response (GO:0052553)2.33433155
164positive regulation by symbiont of host defense response (GO:0052509)2.33433155
165modulation by symbiont of host defense response (GO:0052031)2.33433155
166modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.33433155
167protein localization to mitochondrion (GO:0070585)2.33282045
168neuromuscular process controlling posture (GO:0050884)2.32298894
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.31868537
170synaptic vesicle maturation (GO:0016188)2.31516642
171respiratory burst (GO:0045730)2.30517854
172negative regulation of synaptic transmission (GO:0050805)2.30460499
173regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29035867
174eosinophil migration (GO:0072677)2.28644882
175detection of calcium ion (GO:0005513)2.28194355
176regulation of amyloid precursor protein catabolic process (GO:1902991)2.26412440
177membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.26352815
178gamma-aminobutyric acid transport (GO:0015812)2.25766452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.03398040
2EZH2_22144423_ChIP-Seq_EOC_Human3.96483732
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41836660
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14202821
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.07059622
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.99756292
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88351014
8TAF15_26573619_Chip-Seq_HEK293_Human2.76835566
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73790630
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.65765660
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54855753
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.44618168
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.37868140
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37703878
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34237311
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30809598
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.30608055
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.27186583
19REST_21632747_ChIP-Seq_MESCs_Mouse2.20994621
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20880510
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.17277049
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16769581
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15009483
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13354435
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13129314
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07287755
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07242549
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05836746
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04840099
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03244250
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.01866420
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99803199
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95223120
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95134713
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92820784
36* GABP_19822575_ChIP-Seq_HepG2_Human1.92207677
37VDR_22108803_ChIP-Seq_LS180_Human1.92152307
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91993944
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91993944
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.90847459
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90448332
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88337487
43VDR_23849224_ChIP-Seq_CD4+_Human1.86316147
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85731423
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82888071
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81674320
47* TFEB_21752829_ChIP-Seq_HELA_Human1.81595280
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81514580
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81501713
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80036745
51VDR_21846776_ChIP-Seq_THP-1_Human1.78856538
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.78604659
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77329728
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76965436
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76337651
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.73703133
57* SPI1_23547873_ChIP-Seq_NB4_Human1.71195753
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69165163
59* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68867571
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.68797656
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68465484
62BCL6_27268052_Chip-Seq_Bcells_Human1.67607366
63DCP1A_22483619_ChIP-Seq_HELA_Human1.65746649
64P300_19829295_ChIP-Seq_ESCs_Human1.64446619
65* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60769396
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60322689
67ER_23166858_ChIP-Seq_MCF-7_Human1.58469131
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56316184
69FOXP3_21729870_ChIP-Seq_TREG_Human1.54863191
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53674921
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51336365
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.50321338
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49738896
74IGF1R_20145208_ChIP-Seq_DFB_Human1.49318214
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.49088822
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.47542917
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46509699
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.45188311
79BCOR_27268052_Chip-Seq_Bcells_Human1.44961349
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.44890674
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42858817
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42655731
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41671829
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41228739
85SMAD4_21799915_ChIP-Seq_A2780_Human1.40592469
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40398005
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39630896
88* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38527973
89DROSHA_22980978_ChIP-Seq_HELA_Human1.37075169
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35539067
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35395912
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.35340181
93CTCF_18555785_ChIP-Seq_MESCs_Mouse1.34295247
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33696996
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33691967
96* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33416790
97LXR_22292898_ChIP-Seq_THP-1_Human1.31329450
98XRN2_22483619_ChIP-Seq_HELA_Human1.31198544
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30451767
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29537111
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29087055
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28852589
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.27825071
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.27812405
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27610603
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27073261
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.25653019
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24987370
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24866924
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24451604
111E2F1_20622854_ChIP-Seq_HELA_Human1.24345927
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24138083
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22752894
114VDR_24763502_ChIP-Seq_THP-1_Human1.22641557
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.21465850
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21454243
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21408443
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.20388798
119YY1_22570637_ChIP-Seq_MALME-3M_Human1.19513249
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19100052
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18956945
122P68_20966046_ChIP-Seq_HELA_Human1.18928246
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18035734
124* KDM5A_27292631_Chip-Seq_BREAST_Human1.17894774
125AR_21572438_ChIP-Seq_LNCaP_Human1.16517241
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16217425
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16190225
128FUS_26573619_Chip-Seq_HEK293_Human1.14426857
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13029019
130NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13029019
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12625796
132PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11632594
133PHF8_20622854_ChIP-Seq_HELA_Human1.11018021
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10892576
135CTCF_20526341_ChIP-Seq_ESCs_Human1.09932177
136RNF2_27304074_Chip-Seq_NSC_Mouse1.09910220
137* SA1_27219007_Chip-Seq_Bcells_Human1.09559213
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09491056
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09487829
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09462606
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09377805
142AR_25329375_ChIP-Seq_VCAP_Human1.09224679
143ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09010605
144CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08224203
145JUN_21703547_ChIP-Seq_K562_Human1.07389284
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06251515
147NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05976626
148P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05875996
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05860315
150Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05795475
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05425156
152PRDM14_20953172_ChIP-Seq_ESCs_Human1.05028077
153STAT1_20625510_ChIP-Seq_HELA_Human1.05017270
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04329508
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04138777
156CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03779493
157CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03210017
158* FOXP1_21924763_ChIP-Seq_HESCs_Human1.03082339
159MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02615666
160NANOG_18555785_Chip-Seq_ESCs_Mouse1.02573018
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02347497
162E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02299732
163GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02293145
164GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00788965
165ERG_21242973_ChIP-ChIP_JURKAT_Human1.00004573
166E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99836835
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99283612
168ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98636144
169RUNX2_22187159_ChIP-Seq_PCA_Human0.97202367
170RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96286760
171MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95179906
172ZNF274_21170338_ChIP-Seq_K562_Hela0.92155101
173TAL1_26923725_Chip-Seq_HPCs_Mouse0.91348116
174CMYC_18555785_Chip-Seq_ESCs_Mouse0.91309171
175STAT3_23295773_ChIP-Seq_U87_Human0.91179200
176SOX2_21211035_ChIP-Seq_LN229_Gbm0.91079698
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89759565
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88991285
179SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88823059
180* TCF4_23295773_ChIP-Seq_U87_Human0.88220197
181P53_22387025_ChIP-Seq_ESCs_Mouse0.87746300
182KDM2B_26808549_Chip-Seq_REH_Human0.87027846
183RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84671817
184SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84562622
185SOX2_19829295_ChIP-Seq_ESCs_Human0.84294472
186NANOG_19829295_ChIP-Seq_ESCs_Human0.84294472
187STAT3_18555785_Chip-Seq_ESCs_Mouse0.83609101
188AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82528055
189TP53_18474530_ChIP-ChIP_U2OS_Human0.82298860
190CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81187849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.89780769
2MP0004859_abnormal_synaptic_plasticity3.46601729
3MP0003806_abnormal_nucleotide_metabolis3.16991368
4MP0009046_muscle_twitch3.04278985
5MP0002064_seizures3.02236667
6MP0003635_abnormal_synaptic_transmissio2.86915608
7MP0004270_analgesia2.81204904
8MP0009745_abnormal_behavioral_response2.80155712
9MP0001529_abnormal_vocalization2.77913897
10MP0001905_abnormal_dopamine_level2.74879955
11MP0009840_abnormal_foam_cell2.59466266
12MP0001968_abnormal_touch/_nociception2.58601456
13MP0002736_abnormal_nociception_after2.49582265
14MP0002272_abnormal_nervous_system2.44605447
15MP0009785_altered_susceptibility_to2.42955806
16MP0002735_abnormal_chemical_nociception2.42702624
17MP0002734_abnormal_mechanical_nocicepti2.40486426
18MP0002572_abnormal_emotion/affect_behav2.31413327
19MP0003436_decreased_susceptibility_to2.29338768
20MP0002063_abnormal_learning/memory/cond2.27385630
21MP0001440_abnormal_grooming_behavior2.23629622
22MP0000920_abnormal_myelination2.17967802
23MP0001501_abnormal_sleep_pattern2.16491149
24MP0006276_abnormal_autonomic_nervous2.15027859
25MP0006036_abnormal_mitochondrial_physio2.11445513
26MP0005083_abnormal_biliary_tract2.10662652
27MP0001486_abnormal_startle_reflex2.10429788
28MP0005058_abnormal_lysosome_morphology2.04025446
29MP0001970_abnormal_pain_threshold2.03518859
30MP0002733_abnormal_thermal_nociception2.00025124
31MP0010386_abnormal_urinary_bladder1.98027340
32MP0003724_increased_susceptibility_to1.97331089
33MP0003303_peritoneal_inflammation1.94309493
34MP0003329_amyloid_beta_deposits1.90413961
35MP0004142_abnormal_muscle_tone1.89962522
36MP0005025_abnormal_response_to1.89761847
37MP0002822_catalepsy1.89234326
38MP0002067_abnormal_sensory_capabilities1.88029205
39MP0000343_altered_response_to1.86410215
40MP0001835_abnormal_antigen_presentation1.85004458
41MP0005365_abnormal_bile_salt1.83291569
42MP0005671_abnormal_response_to1.79732197
43MP0005171_absent_coat_pigmentation1.73577595
44MP0003690_abnormal_glial_cell1.66938766
45MP0004742_abnormal_vestibular_system1.65570494
46MP0008875_abnormal_xenobiotic_pharmacok1.64063433
47MP0005387_immune_system_phenotype1.63349221
48MP0001790_abnormal_immune_system1.63349221
49MP0004924_abnormal_behavior1.61626186
50MP0005386_behavior/neurological_phenoty1.61626186
51MP0003183_abnormal_peptide_metabolism1.59157509
52MP0003186_abnormal_redox_activity1.58032814
53MP0006035_abnormal_mitochondrial_morpho1.56332858
54MP0003634_abnormal_glial_cell1.54295426
55MP0008260_abnormal_autophagy1.53327287
56MP0009764_decreased_sensitivity_to1.52122868
57MP0005423_abnormal_somatic_nervous1.51461983
58MP0002139_abnormal_hepatobiliary_system1.51164225
59MP0002277_abnormal_respiratory_mucosa1.49731272
60MP0005645_abnormal_hypothalamus_physiol1.48454096
61MP0002876_abnormal_thyroid_physiology1.48421173
62MP0002229_neurodegeneration1.46011259
63MP0002452_abnormal_antigen_presenting1.45616898
64MP0001986_abnormal_taste_sensitivity1.45445518
65MP0000015_abnormal_ear_pigmentation1.45377380
66MP0000604_amyloidosis1.43951001
67MP0005451_abnormal_body_composition1.43484133
68MP0001845_abnormal_inflammatory_respons1.41754158
69MP0001984_abnormal_olfaction1.41515432
70MP0003191_abnormal_cellular_cholesterol1.40157833
71MP0002723_abnormal_immune_serum1.39427636
72MP0003172_abnormal_lysosome_physiology1.39077408
73MP0008469_abnormal_protein_level1.36057276
74MP0005646_abnormal_pituitary_gland1.35733111
75MP0002420_abnormal_adaptive_immunity1.35426314
76MP0001819_abnormal_immune_cell1.33684812
77MP0003195_calcinosis1.33100788
78MP0000778_abnormal_nervous_system1.31864688
79MP0002066_abnormal_motor_capabilities/c1.29437886
80MP0005075_abnormal_melanosome_morpholog1.28597130
81MP0001502_abnormal_circadian_rhythm1.28154616
82MP0001853_heart_inflammation1.26941320
83MP0006082_CNS_inflammation1.26417927
84MP0005464_abnormal_platelet_physiology1.24603087
85MP0003122_maternal_imprinting1.24217648
86MP0002557_abnormal_social/conspecific_i1.22110656
87MP0003011_delayed_dark_adaptation1.20084959
88MP0004858_abnormal_nervous_system1.19846228
89MP0002693_abnormal_pancreas_physiology1.19672388
90MP0004043_abnormal_pH_regulation1.19509577
91MP0003786_premature_aging1.18655879
92MP0002837_dystrophic_cardiac_calcinosis1.17874866
93MP0002184_abnormal_innervation1.17343554
94MP0004019_abnormal_vitamin_homeostasis1.16579690
95MP0002882_abnormal_neuron_morphology1.15999854
96MP0001800_abnormal_humoral_immune1.15514561
97MP0005310_abnormal_salivary_gland1.15097557
98MP0004885_abnormal_endolymph1.14649867
99MP0003633_abnormal_nervous_system1.11785082
100MP0005551_abnormal_eye_electrophysiolog1.11347431
101MP0002132_abnormal_respiratory_system1.11319424
102MP0001188_hyperpigmentation1.11304073
103MP0001533_abnormal_skeleton_physiology1.11169348
104MP0000685_abnormal_immune_system1.11145806
105MP0000955_abnormal_spinal_cord1.10964028
106MP0008569_lethality_at_weaning1.10653074
107MP0003879_abnormal_hair_cell1.10500742
108MP0005535_abnormal_body_temperature1.10156704
109MP0003631_nervous_system_phenotype1.09654023
110MP0008058_abnormal_DNA_repair1.07159688
111MP0009333_abnormal_splenocyte_physiolog1.06975440
112MP0002638_abnormal_pupillary_reflex1.06803736
113MP0001764_abnormal_homeostasis1.06231307
114MP0003632_abnormal_nervous_system1.06180865
115MP0002090_abnormal_vision1.05919386
116MP0002148_abnormal_hypersensitivity_rea1.05366399
117MP0009780_abnormal_chondrocyte_physiolo1.04018926
118MP0001963_abnormal_hearing_physiology1.02366376
119MP0005332_abnormal_amino_acid1.01949514
120MP0004811_abnormal_neuron_physiology1.01375400
121MP0005167_abnormal_blood-brain_barrier1.00740131
122MP0000013_abnormal_adipose_tissue1.00313265
123MP0005166_decreased_susceptibility_to0.97991273
124MP0005584_abnormal_enzyme/coenzyme_acti0.96442343
125MP0002909_abnormal_adrenal_gland0.94238272
126MP0005085_abnormal_gallbladder_physiolo0.94075826
127MP0005379_endocrine/exocrine_gland_phen0.93851679
128MP0000358_abnormal_cell_content/0.91684820
129MP0005319_abnormal_enzyme/_coenzyme0.89345561
130MP0005409_darkened_coat_color0.88696582
131MP0004510_myositis0.87783807
132MP0001756_abnormal_urination0.86938420
133MP0002332_abnormal_exercise_endurance0.86350521
134MP0005084_abnormal_gallbladder_morpholo0.86313567
135MP0003136_yellow_coat_color0.85097917
136MP0000716_abnormal_immune_system0.84259802
137MP0003123_paternal_imprinting0.83392693
138MP0005636_abnormal_mineral_homeostasis0.83004954
139MP0001664_abnormal_digestion0.82984338
140MP0009643_abnormal_urine_homeostasis0.82338815
141MP0001485_abnormal_pinna_reflex0.80678384
142MP0002405_respiratory_system_inflammati0.79716888
143MP0002069_abnormal_eating/drinking_beha0.76137128
144MP0003075_altered_response_to0.76081685
145MP0010329_abnormal_lipoprotein_level0.75511947
146MP0008873_increased_physiological_sensi0.75054677
147MP0000372_irregular_coat_pigmentation0.73553366
148MP0002419_abnormal_innate_immunity0.73376465
149MP0005410_abnormal_fertilization0.71281528
150MP0005253_abnormal_eye_physiology0.70705585
151MP0002752_abnormal_somatic_nervous0.70216605
152MP0008872_abnormal_physiological_respon0.66632329
153MP0008874_decreased_physiological_sensi0.66160979
154MP0000538_abnormal_urinary_bladder0.65550993
155MP0000681_abnormal_thyroid_gland0.65239916
156MP0002163_abnormal_gland_morphology0.64093811
157MP0001727_abnormal_embryo_implantation0.63278076
158MP0003787_abnormal_imprinting0.62996371
159MP0005164_abnormal_response_to0.62931884
160MP0005000_abnormal_immune_tolerance0.62516428

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.75517717
2Acute necrotizing encephalopathy (HP:0006965)4.25837025
3Atonic seizures (HP:0010819)3.98264281
4Abnormal mitochondria in muscle tissue (HP:0008316)3.79365291
5Mitochondrial inheritance (HP:0001427)3.73381532
6Myokymia (HP:0002411)3.62324725
7Pheochromocytoma (HP:0002666)3.62301311
8Neurofibrillary tangles (HP:0002185)3.58838892
9Progressive macrocephaly (HP:0004481)3.57050388
10Neuroendocrine neoplasm (HP:0100634)3.47188622
11Epileptic encephalopathy (HP:0200134)3.42535105
12Loss of speech (HP:0002371)3.40356256
13Supranuclear gaze palsy (HP:0000605)3.28557005
14Limb dystonia (HP:0002451)3.24945069
15Acute encephalopathy (HP:0006846)3.24306463
16Focal seizures (HP:0007359)3.18690055
17Increased intramyocellular lipid droplets (HP:0012240)3.16467906
18Visual hallucinations (HP:0002367)3.16075567
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.12134277
20Hepatocellular necrosis (HP:0001404)3.11326366
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09095151
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09095151
23Hypothermia (HP:0002045)3.00945575
24Absence seizures (HP:0002121)2.99690325
25Dialeptic seizures (HP:0011146)2.97244312
26Cerebral inclusion bodies (HP:0100314)2.96264658
27Increased CSF lactate (HP:0002490)2.95117136
28Abnormality of liposaccharide metabolism (HP:0010968)2.88453373
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.88453373
30Abnormality of glycolipid metabolism (HP:0010969)2.88453373
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.86009476
32Increased muscle lipid content (HP:0009058)2.84811688
33Polyphagia (HP:0002591)2.79269786
34Vacuolated lymphocytes (HP:0001922)2.75251579
35Akinesia (HP:0002304)2.74068746
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.72462679
37Increased cerebral lipofuscin (HP:0011813)2.72388945
38Obstructive lung disease (HP:0006536)2.69018210
39Chronic obstructive pulmonary disease (HP:0006510)2.69018210
40Generalized tonic-clonic seizures (HP:0002069)2.68738533
41Sensory axonal neuropathy (HP:0003390)2.68263464
42Renal Fanconi syndrome (HP:0001994)2.67935584
43Petechiae (HP:0000967)2.67304714
44Abnormal hair whorl (HP:0010721)2.65374487
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.63284269
46Febrile seizures (HP:0002373)2.61627734
47Medial flaring of the eyebrow (HP:0010747)2.60874128
48Leukodystrophy (HP:0002415)2.58600503
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57966129
50Parakeratosis (HP:0001036)2.57134873
51Generalized aminoaciduria (HP:0002909)2.55886506
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.55654911
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.55654911
54Gait imbalance (HP:0002141)2.55125419
55Hyperventilation (HP:0002883)2.51602216
56Abnormality of glycolysis (HP:0004366)2.50836811
57Increased serum pyruvate (HP:0003542)2.50836811
58Increased hepatocellular lipid droplets (HP:0006565)2.50360796
59Stomatitis (HP:0010280)2.48889425
60Eczematoid dermatitis (HP:0000976)2.43775577
61Optic disc pallor (HP:0000543)2.41393758
62Progressive cerebellar ataxia (HP:0002073)2.40498416
63Exertional dyspnea (HP:0002875)2.37157776
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36913223
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36913223
66Abnormality of polysaccharide metabolism (HP:0011012)2.36913223
67Congenital primary aphakia (HP:0007707)2.36554197
68Recurrent abscess formation (HP:0002722)2.35411004
69Failure to thrive in infancy (HP:0001531)2.31435279
70Hepatic necrosis (HP:0002605)2.30661382
71Abnormality of macrophages (HP:0004311)2.30402343
72Vaginal atresia (HP:0000148)2.30166614
73Cerebral hemorrhage (HP:0001342)2.29395680
74Dysostosis multiplex (HP:0000943)2.27300037
75Increased serum lactate (HP:0002151)2.26683521
76Nephrogenic diabetes insipidus (HP:0009806)2.26603830
77Mutism (HP:0002300)2.26353796
78Genital tract atresia (HP:0001827)2.25961310
79Progressive inability to walk (HP:0002505)2.25675826
80Abnormal eating behavior (HP:0100738)2.24922126
81Respiratory failure (HP:0002878)2.24760277
82Prolonged neonatal jaundice (HP:0006579)2.22542256
83Respiratory difficulties (HP:0002880)2.21497549
84Progressive microcephaly (HP:0000253)2.21482566
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20863000
86Hepatosplenomegaly (HP:0001433)2.19960993
87Diminished movement (HP:0002374)2.19351942
88Recurrent bacterial skin infections (HP:0005406)2.17547850
89Dysmetria (HP:0001310)2.16870888
90Recurrent gram-negative bacterial infections (HP:0005420)2.15754030
91Mediastinal lymphadenopathy (HP:0100721)2.10360680
92CNS demyelination (HP:0007305)2.10202963
93Myoclonus (HP:0001336)2.07962683
94Emotional lability (HP:0000712)2.05493447
95Anxiety (HP:0000739)2.04322198
96Mucopolysacchariduria (HP:0008155)2.04110357
97Urinary glycosaminoglycan excretion (HP:0003541)2.04110357
98Systemic lupus erythematosus (HP:0002725)2.02116499
99Broad-based gait (HP:0002136)2.02063922
100Neuronal loss in central nervous system (HP:0002529)2.01522630
101Lipid accumulation in hepatocytes (HP:0006561)2.01018965
102Abnormality of the corticospinal tract (HP:0002492)2.00359148
103Hypokinesia (HP:0002375)2.00047269
104Retinal dysplasia (HP:0007973)1.99384443
105Delusions (HP:0000746)1.98995445
106Disinhibition (HP:0000734)1.98310977
107Episodic fever (HP:0001954)1.98184953
108Poor suck (HP:0002033)1.97362170
109Nausea (HP:0002018)1.93642732
110Congenital ichthyosiform erythroderma (HP:0007431)1.93320924
111Diplopia (HP:0000651)1.93029727
112Abnormality of binocular vision (HP:0011514)1.93029727
113Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92990640
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92961856
115Generalized myoclonic seizures (HP:0002123)1.92385162
1163-Methylglutaconic aciduria (HP:0003535)1.91798274
117Psychosis (HP:0000709)1.90911611
118Myositis (HP:0100614)1.90900217
119Abnormality of renal resorption (HP:0011038)1.90792397
120Glycosuria (HP:0003076)1.89947199
121Abnormality of urine glucose concentration (HP:0011016)1.89947199
122Microvesicular hepatic steatosis (HP:0001414)1.89492604
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88989999
124Dicarboxylic aciduria (HP:0003215)1.88989999
125Ketoacidosis (HP:0001993)1.88017951
126Esotropia (HP:0000565)1.87779374
127Gaze-evoked nystagmus (HP:0000640)1.87432115
128Spastic gait (HP:0002064)1.87195499
129Retinal atrophy (HP:0001105)1.86523104
130Agitation (HP:0000713)1.86126526
131Recurrent skin infections (HP:0001581)1.86117827
132Increased serum ferritin (HP:0003281)1.85079808
133J-shaped sella turcica (HP:0002680)1.83116217
134Methylmalonic aciduria (HP:0012120)1.82934387
135Cerebral edema (HP:0002181)1.82848581
136Epileptiform EEG discharges (HP:0011182)1.82236769
137Cerebral hypomyelination (HP:0006808)1.80938010
138Testicular atrophy (HP:0000029)1.80365137
139Axonal loss (HP:0003447)1.80308866
140Ankle clonus (HP:0011448)1.80067225
141Fetal akinesia sequence (HP:0001989)1.77738095
142Abnormality of the anterior horn cell (HP:0006802)1.77634501
143Degeneration of anterior horn cells (HP:0002398)1.77634501
144Progressive neurologic deterioration (HP:0002344)1.77540699
145Elevated erythrocyte sedimentation rate (HP:0003565)1.77298849
146Peripheral hypomyelination (HP:0007182)1.77266520
147Abnormal gallbladder physiology (HP:0012438)1.77213664
148Cholecystitis (HP:0001082)1.77213664
149Gliosis (HP:0002171)1.76825985
150Exercise intolerance (HP:0003546)1.75743163
151Oligomenorrhea (HP:0000876)1.74540507
152Microretrognathia (HP:0000308)1.74289810
153Lactic acidosis (HP:0003128)1.73765182
154Lethargy (HP:0001254)1.73433721
155Ragged-red muscle fibers (HP:0003200)1.71702930
156Diminished motivation (HP:0000745)1.70567858
157Urticaria (HP:0001025)1.69187320
158Type I transferrin isoform profile (HP:0003642)1.68612178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.04753206
2NME23.75773007
3TESK23.33419142
4MAP3K123.24901452
5ARAF3.16784720
6VRK22.88118896
7OXSR12.83799386
8RIPK42.82968014
9TESK12.69171894
10MAP3K112.52422563
11STK392.49901010
12BCKDK2.47005595
13NTRK32.37836238
14EPHA42.32686870
15ERN12.27600889
16CDK192.18442821
17CCNB12.15233282
18MAP2K72.08860283
19PBK1.98506093
20GRK51.97242713
21PDK21.84347473
22PLK21.83957984
23TNIK1.80953620
24PRPF4B1.78792975
25MAP3K41.72901568
26TAOK11.63808336
27BCR1.63338565
28TYK21.62578575
29BMPR21.60677463
30MAP3K91.57947523
31DAPK21.56572619
32GRK71.53915419
33MAP4K21.52375540
34PNCK1.51356911
35NTRK11.50180044
36NME11.49016285
37WNK41.48634742
38FGR1.41065029
39MAPKAPK51.39136919
40MARK11.38772813
41TBK11.38629380
42MAP3K31.34701594
43CAMK2B1.33532537
44BRAF1.31015781
45TNK21.29969428
46ADRBK21.26670201
47MINK11.26501455
48MAP4K11.25913239
49TLK11.21941815
50BMPR1B1.16942767
51CSNK1G31.15311164
52MAP2K61.12670102
53IKBKB1.11948915
54CDK51.11895406
55CAMK2A1.10430985
56TXK1.08593942
57TAOK21.08099825
58CAMK2D1.08045969
59STK161.07842304
60MAP2K31.07760649
61PKN11.07576885
62DAPK11.07530920
63CAMKK21.07427633
64FES1.06775722
65CAMK1D1.03828995
66PRKCE1.03031979
67CSNK1G21.02729602
68LIMK10.99108893
69MST40.98291673
70UHMK10.97632790
71SIK30.96844102
72MAPK130.96406349
73TRIM280.96308460
74MAP3K130.95956983
75CSK0.95728685
76PRKCG0.94249223
77MAP2K40.92597817
78SGK4940.88889477
79SGK2230.88889477
80MAP3K50.88112034
81CAMK2G0.86498791
82PINK10.86026737
83PAK60.84768967
84CDK140.83480522
85NTRK20.81418611
86KSR20.79424480
87KDR0.78955188
88PIM20.77888400
89CDK180.77300245
90PTK2B0.77217756
91MATK0.77210452
92IKBKE0.76567015
93ZAP700.74723913
94NEK60.73856470
95GRK10.73788449
96GRK60.73142172
97LRRK20.73047283
98BUB10.72724471
99TAOK30.72458309
100CDK150.71801185
101MYLK0.70637265
102DAPK30.70180942
103PRKCI0.69865497
104LYN0.68901775
105AKT30.66517338
106ADRBK10.66372157
107TSSK60.66155979
108MAP3K140.66007420
109ROCK20.65039030
110IRAK40.64832452
111EPHB10.63787210
112ABL20.61508544
113CDK11A0.61328653
114MUSK0.60306085
115VRK10.59622900
116CSNK1G10.57094118
117PDPK10.56556430
118BLK0.56167361
119PHKG20.55003980
120PHKG10.55003980
121MAP3K20.53788204
122MET0.53325374
123IRAK30.50770848
124ZAK0.49915542
125WNK10.49132452
126SYK0.48705819
127CSNK1A1L0.48231612
128RPS6KA50.47865292
129WNK30.47570462
130ERBB40.47286805
131PAK40.46364895
132MOS0.45954342
133PAK10.45208552
134PRKG20.44888032
135DYRK20.44675642
136DYRK1A0.44398221
137CHUK0.43941275
138YES10.43786745
139FYN0.43282133
140MAP3K10.42639593
141MAPK150.41848137
142PRKACA0.41599097
143CAMKK10.40835666
144PRKCQ0.39342352
145MST1R0.36275428
146EIF2AK10.35792240
147PRKCD0.35566580
148CSNK1A10.34572991
149IRAK20.33804455
150LCK0.32437442
151CAMK10.30222343
152PDK10.29226352
153HCK0.27864243

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.44576301
2* Oxidative phosphorylation_Homo sapiens_hsa001904.07511146
3* Synaptic vesicle cycle_Homo sapiens_hsa047213.58720655
4Parkinsons disease_Homo sapiens_hsa050123.00137405
5* Vibrio cholerae infection_Homo sapiens_hsa051102.82033067
6Nicotine addiction_Homo sapiens_hsa050332.63251310
7Alzheimers disease_Homo sapiens_hsa050102.53867440
8* Rheumatoid arthritis_Homo sapiens_hsa053232.33965055
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93655032
10Protein export_Homo sapiens_hsa030601.89472746
11Huntingtons disease_Homo sapiens_hsa050161.89279894
12* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.89023479
13GABAergic synapse_Homo sapiens_hsa047271.87945111
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78733815
15* Phagosome_Homo sapiens_hsa041451.77423419
16Morphine addiction_Homo sapiens_hsa050321.71774656
17Serotonergic synapse_Homo sapiens_hsa047261.68204226
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63851277
19* Lysosome_Homo sapiens_hsa041421.61261784
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60701228
21Amphetamine addiction_Homo sapiens_hsa050311.51530959
22Staphylococcus aureus infection_Homo sapiens_hsa051501.47487644
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46619757
24Circadian entrainment_Homo sapiens_hsa047131.46179018
25Glutamatergic synapse_Homo sapiens_hsa047241.44871571
26Cocaine addiction_Homo sapiens_hsa050301.43093015
27Proteasome_Homo sapiens_hsa030501.42586206
28Olfactory transduction_Homo sapiens_hsa047401.39981286
29Dopaminergic synapse_Homo sapiens_hsa047281.39467297
30Folate biosynthesis_Homo sapiens_hsa007901.38824699
31Taste transduction_Homo sapiens_hsa047421.35210661
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32043068
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30304603
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29615733
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28670090
36Cardiac muscle contraction_Homo sapiens_hsa042601.28390720
37RNA polymerase_Homo sapiens_hsa030201.25843461
38Glutathione metabolism_Homo sapiens_hsa004801.24472894
39Fatty acid elongation_Homo sapiens_hsa000621.23585978
40Long-term potentiation_Homo sapiens_hsa047201.21525096
41Steroid biosynthesis_Homo sapiens_hsa001001.19839612
42Long-term depression_Homo sapiens_hsa047301.17187973
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15261790
44Phototransduction_Homo sapiens_hsa047441.12849841
45Other glycan degradation_Homo sapiens_hsa005111.12560025
46Ether lipid metabolism_Homo sapiens_hsa005651.12538751
47Sulfur relay system_Homo sapiens_hsa041221.12510488
48Insulin secretion_Homo sapiens_hsa049111.12134650
49Type I diabetes mellitus_Homo sapiens_hsa049401.10519030
50Sphingolipid metabolism_Homo sapiens_hsa006001.10441622
51Cholinergic synapse_Homo sapiens_hsa047251.09862943
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08800164
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06610820
54Salivary secretion_Homo sapiens_hsa049701.05408044
55Osteoclast differentiation_Homo sapiens_hsa043801.00961925
56Regulation of autophagy_Homo sapiens_hsa041400.99233805
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97506448
58Leishmaniasis_Homo sapiens_hsa051400.96843909
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92153966
60Pyrimidine metabolism_Homo sapiens_hsa002400.89378824
61Sulfur metabolism_Homo sapiens_hsa009200.88444769
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87791224
63Renin secretion_Homo sapiens_hsa049240.87056430
64Fructose and mannose metabolism_Homo sapiens_hsa000510.82627407
65Calcium signaling pathway_Homo sapiens_hsa040200.81745316
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.80882650
67Antigen processing and presentation_Homo sapiens_hsa046120.79929452
68Peroxisome_Homo sapiens_hsa041460.78370541
69Galactose metabolism_Homo sapiens_hsa000520.77820889
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77154563
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76180371
72Gastric acid secretion_Homo sapiens_hsa049710.74857297
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.74473963
74Graft-versus-host disease_Homo sapiens_hsa053320.74452812
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.70884510
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70433534
77Vitamin B6 metabolism_Homo sapiens_hsa007500.70328225
78Asthma_Homo sapiens_hsa053100.68442486
79* Tuberculosis_Homo sapiens_hsa051520.64658927
80Salmonella infection_Homo sapiens_hsa051320.63799905
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62187611
82Ribosome_Homo sapiens_hsa030100.62048583
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60017623
84Axon guidance_Homo sapiens_hsa043600.59240669
85Base excision repair_Homo sapiens_hsa034100.57225646
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57055568
87Prion diseases_Homo sapiens_hsa050200.56800038
88Pertussis_Homo sapiens_hsa051330.56489062
89African trypanosomiasis_Homo sapiens_hsa051430.56397442
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.55541172
91Pancreatic secretion_Homo sapiens_hsa049720.55313519
92Oxytocin signaling pathway_Homo sapiens_hsa049210.53968070
93Pentose phosphate pathway_Homo sapiens_hsa000300.53258537
94Shigellosis_Homo sapiens_hsa051310.52133050
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51864315
96Gap junction_Homo sapiens_hsa045400.51647222
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.47249137
98N-Glycan biosynthesis_Homo sapiens_hsa005100.45480836
99Carbon metabolism_Homo sapiens_hsa012000.44754178
100GnRH signaling pathway_Homo sapiens_hsa049120.44093684
101cAMP signaling pathway_Homo sapiens_hsa040240.41345486
102Mineral absorption_Homo sapiens_hsa049780.40967763
103Endocytosis_Homo sapiens_hsa041440.40922713
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.40190304
105Selenocompound metabolism_Homo sapiens_hsa004500.40167230
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40036402
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.39027468
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38173360
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.38128935
110Malaria_Homo sapiens_hsa051440.38114884
111Hematopoietic cell lineage_Homo sapiens_hsa046400.37671800
112Purine metabolism_Homo sapiens_hsa002300.36898954
113Tryptophan metabolism_Homo sapiens_hsa003800.35662060
114Epstein-Barr virus infection_Homo sapiens_hsa051690.35509358
115Autoimmune thyroid disease_Homo sapiens_hsa053200.35134105
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34543186
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34357448
118Type II diabetes mellitus_Homo sapiens_hsa049300.34136223
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34123629
120Allograft rejection_Homo sapiens_hsa053300.34063351
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33552881
122Chemokine signaling pathway_Homo sapiens_hsa040620.33366721
123Pyruvate metabolism_Homo sapiens_hsa006200.33285362
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32398265
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32264979
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31425876
127Arachidonic acid metabolism_Homo sapiens_hsa005900.30962042
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30352686
129ErbB signaling pathway_Homo sapiens_hsa040120.29505070
130Butanoate metabolism_Homo sapiens_hsa006500.28813795
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28502878
132Renin-angiotensin system_Homo sapiens_hsa046140.28106258
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27925417
134* Metabolic pathways_Homo sapiens_hsa011000.26713262
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.26331523
136Ras signaling pathway_Homo sapiens_hsa040140.25890034
137Alcoholism_Homo sapiens_hsa050340.25868725
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25860144
139Legionellosis_Homo sapiens_hsa051340.25065588
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25008025
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24719446
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24548643
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22641912
144Estrogen signaling pathway_Homo sapiens_hsa049150.21464202
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20595061
146beta-Alanine metabolism_Homo sapiens_hsa004100.19581747
147Basal transcription factors_Homo sapiens_hsa030220.19324942
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17667478
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17249727
150Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.17098793

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