ATP6V0C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.81726376
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48115894
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.23164573
4glutamate secretion (GO:0014047)5.15937364
5regulation of synaptic vesicle exocytosis (GO:2000300)5.01467195
6* transferrin transport (GO:0033572)4.87577412
7synaptic vesicle maturation (GO:0016188)4.80620077
8* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.71496663
9* ATP hydrolysis coupled proton transport (GO:0015991)4.71496663
10vocalization behavior (GO:0071625)4.64571922
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.61039610
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.60893237
13* trivalent inorganic cation transport (GO:0072512)4.49458391
14* ferric iron transport (GO:0015682)4.49458391
15regulation of synaptic vesicle transport (GO:1902803)4.48776226
16* phagosome maturation (GO:0090382)4.42132489
17neuronal action potential propagation (GO:0019227)4.36816716
18regulation of glutamate receptor signaling pathway (GO:1900449)4.36650396
19neurotransmitter secretion (GO:0007269)4.33106173
20neurotransmitter-gated ion channel clustering (GO:0072578)4.28340063
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.26356222
22neuron cell-cell adhesion (GO:0007158)4.18093225
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.07858496
24protein localization to synapse (GO:0035418)4.05263386
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03791586
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.97389537
27locomotory exploration behavior (GO:0035641)3.91756129
28negative regulation of erythrocyte differentiation (GO:0045647)3.90000386
29neuron-neuron synaptic transmission (GO:0007270)3.75512463
30sodium ion export (GO:0071436)3.74381757
31synaptic transmission, glutamatergic (GO:0035249)3.68580032
32proline transport (GO:0015824)3.66560884
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.61197098
34long-term synaptic potentiation (GO:0060291)3.59600971
35regulation of early endosome to late endosome transport (GO:2000641)3.57620270
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56715030
37neuromuscular process controlling posture (GO:0050884)3.56520739
38glutamate receptor signaling pathway (GO:0007215)3.54309797
39negative regulation of amino acid transport (GO:0051956)3.46283996
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44987393
41neurotransmitter transport (GO:0006836)3.42451098
42protein localization to endosome (GO:0036010)3.40304373
43positive regulation of synapse maturation (GO:0090129)3.35215825
44regulation of neuronal synaptic plasticity (GO:0048168)3.33355251
45positive regulation of neurotransmitter transport (GO:0051590)3.31094206
46postsynaptic membrane organization (GO:0001941)3.28608160
47presynaptic membrane assembly (GO:0097105)3.28088424
48regulation of neurotransmitter secretion (GO:0046928)3.27060403
49gamma-aminobutyric acid transport (GO:0015812)3.26244321
50regulation of synapse structural plasticity (GO:0051823)3.25902895
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24955934
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.24713766
53regulation of neurotransmitter levels (GO:0001505)3.21290234
54exploration behavior (GO:0035640)3.20868156
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19225911
56positive regulation of membrane potential (GO:0045838)3.19047530
57response to histamine (GO:0034776)3.18858336
58regulation of glutamate secretion (GO:0014048)3.17392152
59synaptic vesicle endocytosis (GO:0048488)3.17116078
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.12770135
61regulation of synaptic plasticity (GO:0048167)3.11100643
62regulation of neurotransmitter transport (GO:0051588)3.08826718
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07903867
64presynaptic membrane organization (GO:0097090)3.05854605
65startle response (GO:0001964)3.05058199
66response to peptidoglycan (GO:0032494)3.04690599
67regulation of vesicle fusion (GO:0031338)3.03454335
68establishment of synaptic vesicle localization (GO:0097480)3.02778023
69synaptic vesicle transport (GO:0048489)3.02778023
70activation of MAPKKK activity (GO:0000185)3.02395244
71regulation of postsynaptic membrane potential (GO:0060078)3.02207570
72cellular potassium ion homeostasis (GO:0030007)3.02122049
73positive regulation of neurotransmitter secretion (GO:0001956)3.00282209
74long-term memory (GO:0007616)2.98854593
75positive regulation of synaptic transmission (GO:0050806)2.97379441
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95458001
77negative regulation of dendrite morphogenesis (GO:0050774)2.95410325
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94889924
79cell-cell junction maintenance (GO:0045217)2.93820715
80positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92955713
81regulation of ARF protein signal transduction (GO:0032012)2.90937923
82cerebellar granule cell differentiation (GO:0021707)2.89635888
83barbed-end actin filament capping (GO:0051016)2.89033308
84synaptic transmission (GO:0007268)2.86378846
85* iron ion transport (GO:0006826)2.84477792
86modulation by virus of host process (GO:0019054)2.83696402
87response to acidic pH (GO:0010447)2.83490282
88activation of protein kinase A activity (GO:0034199)2.82324230
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81990479
90negative regulation of cell killing (GO:0031342)2.81990479
91NADH metabolic process (GO:0006734)2.81205901
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81059114
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.81059114
94modulation by symbiont of host immune response (GO:0052553)2.81059114
95positive regulation by symbiont of host defense response (GO:0052509)2.81059114
96modulation by symbiont of host defense response (GO:0052031)2.81059114
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81059114
98regulation of synaptic transmission, dopaminergic (GO:0032225)2.80933329
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80624319
100cerebellar Purkinje cell differentiation (GO:0021702)2.80035225
101modulation by symbiont of host cellular process (GO:0044068)2.79926779
102regulation of synaptic transmission (GO:0050804)2.77615348
103positive regulation of protein dephosphorylation (GO:0035307)2.77305541
104regulation of regulated secretory pathway (GO:1903305)2.76728515
105serotonin metabolic process (GO:0042428)2.76506293
106response to auditory stimulus (GO:0010996)2.76362420
107signal complex assembly (GO:0007172)2.75541286
108protein retention in ER lumen (GO:0006621)2.74534658
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.74528343
110regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.74189277
111regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.74189277
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.73514873
113cerebellar Purkinje cell layer development (GO:0021680)2.72826272
114positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72480394
115behavioral response to cocaine (GO:0048148)2.71299309
116regulation of exocytosis (GO:0017157)2.70875937
117regulation of synaptic transmission, GABAergic (GO:0032228)2.70052922
118regulation of T-helper 2 cell differentiation (GO:0045628)2.68725413
119positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.68630697
120regulation of synapse maturation (GO:0090128)2.67544947
121positive regulation of exocytosis (GO:0045921)2.66875707
122establishment of vesicle localization (GO:0051650)2.65231319
123membrane depolarization (GO:0051899)2.65198105
124G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64758558
125macrophage activation involved in immune response (GO:0002281)2.64620276
126striatum development (GO:0021756)2.64177018
127regulation of leukocyte degranulation (GO:0043300)2.62720681
128regulation of voltage-gated calcium channel activity (GO:1901385)2.62005643
129adenosine receptor signaling pathway (GO:0001973)2.61982943
130membrane hyperpolarization (GO:0060081)2.59405017
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58917227
132cytoskeletal anchoring at plasma membrane (GO:0007016)2.58132299
133long term synaptic depression (GO:0060292)2.57304771
134neutrophil activation involved in immune response (GO:0002283)2.55561672
135regulation of defense response to virus by virus (GO:0050690)2.55284751
136dopamine receptor signaling pathway (GO:0007212)2.52808316
137response to parathyroid hormone (GO:0071107)2.51137741
138regulation of mast cell degranulation (GO:0043304)2.49472163
139mannose metabolic process (GO:0006013)2.49229315
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48611679
141neuromuscular process controlling balance (GO:0050885)2.47279780
142amino acid import (GO:0043090)2.46509398
143maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43972836
144cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.42395241
145cellular response to thyroid hormone stimulus (GO:0097067)2.42031240
146stress fiber assembly (GO:0043149)2.41935996
147L-amino acid import (GO:0043092)2.41488690
148negative regulation of interleukin-12 production (GO:0032695)2.41379420
149regulation of myeloid leukocyte mediated immunity (GO:0002886)2.40739692
150protein targeting to plasma membrane (GO:0072661)2.38817348
151regulation of protein dephosphorylation (GO:0035304)2.34715416
152regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32996212
153positive regulation of regulated secretory pathway (GO:1903307)2.32328899
154establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.31460356
155mitochondrion transport along microtubule (GO:0047497)2.31460356
156adhesion of symbiont to host cell (GO:0044650)2.29523520
157virion attachment to host cell (GO:0019062)2.29523520
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.28889095
159regulation of ARF GTPase activity (GO:0032312)2.27595563
160layer formation in cerebral cortex (GO:0021819)2.27547024
161adhesion of symbiont to host (GO:0044406)2.25207295
162positive regulation of cellular amide metabolic process (GO:0034250)2.23538921
163amino sugar catabolic process (GO:0046348)2.21978588
164regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.21045648
165establishment of mitochondrion localization (GO:0051654)2.20102060
166response to muramyl dipeptide (GO:0032495)2.19124244
167neuronal ion channel clustering (GO:0045161)2.18961132
168glycosphingolipid catabolic process (GO:0046479)2.18097373
169response to dietary excess (GO:0002021)2.17994857
170cell migration in hindbrain (GO:0021535)2.17412778
171endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.16785396
172actin filament polymerization (GO:0030041)2.16561759
173respiratory system process (GO:0003016)2.15108886
174positive regulation of fibroblast migration (GO:0010763)2.14491376
175cell junction maintenance (GO:0034331)2.13895537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44698835
2GBX2_23144817_ChIP-Seq_PC3_Human4.27293085
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23479704
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.11054605
5LXR_22292898_ChIP-Seq_THP-1_Human3.08665940
6REST_21632747_ChIP-Seq_MESCs_Mouse3.05720643
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03369437
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91142179
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83591299
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70628834
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.69178801
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67670744
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.66984267
14VDR_21846776_ChIP-Seq_THP-1_Human2.60435563
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60267202
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.58711567
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58396127
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52226026
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51766246
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.50179935
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48032743
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45261298
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44497158
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40780284
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34615728
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34615728
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.30194415
28KDM2B_26808549_Chip-Seq_DND41_Human2.22709256
29KDM2B_26808549_Chip-Seq_K562_Human2.20242153
30RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15519055
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13084990
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.12798232
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12340392
34TAF15_26573619_Chip-Seq_HEK293_Human2.07675050
35EED_16625203_ChIP-ChIP_MESCs_Mouse2.05195535
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03643042
37RACK7_27058665_Chip-Seq_MCF-7_Human2.01247137
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.96208704
39DROSHA_22980978_ChIP-Seq_HELA_Human1.96111952
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.95683105
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94980300
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.94395129
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.90113476
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86975040
45TCF7_22412390_ChIP-Seq_EML_Mouse1.86739518
46MYC_22102868_ChIP-Seq_BL_Human1.84373883
47P68_20966046_ChIP-Seq_HELA_Human1.79938466
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.79752978
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.69660527
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67237401
51VDR_24763502_ChIP-Seq_THP-1_Human1.65708782
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63581056
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.63539724
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.63283030
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.62883087
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61622588
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59958433
58* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59010050
59SMAD4_21799915_ChIP-Seq_A2780_Human1.57833070
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.55912743
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.55336070
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52039959
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51594833
64SMC4_20622854_ChIP-Seq_HELA_Human1.50134018
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49497023
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49151204
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48859533
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47724575
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.47666018
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45022766
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43642835
72P300_19829295_ChIP-Seq_ESCs_Human1.41948079
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41814201
74CREB1_26743006_Chip-Seq_LNCaP_Human1.41790801
75CTCF_27219007_Chip-Seq_Bcells_Human1.41754752
76* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41221552
77VDR_22108803_ChIP-Seq_LS180_Human1.37685166
78AR_25329375_ChIP-Seq_VCAP_Human1.36388580
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.35817920
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35306824
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34398657
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33779325
83BCL6_27268052_Chip-Seq_Bcells_Human1.32644020
84BCOR_27268052_Chip-Seq_Bcells_Human1.31883030
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.31221304
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29363605
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23988622
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23452788
89MAF_26560356_Chip-Seq_TH1_Human1.22346107
90* RUNX1_22412390_ChIP-Seq_EML_Mouse1.21496140
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21016208
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20721711
93IGF1R_20145208_ChIP-Seq_DFB_Human1.20631605
94MAF_26560356_Chip-Seq_TH2_Human1.20558338
95SA1_27219007_Chip-Seq_Bcells_Human1.20239766
96UTX_26944678_Chip-Seq_JUKART_Human1.19936253
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.18885831
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17802530
99* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16867000
100AR_21572438_ChIP-Seq_LNCaP_Human1.16520124
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15796963
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14934222
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.14644853
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14522173
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14348728
106* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13593759
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13383231
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12141171
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12118927
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11962185
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11566061
112* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11372819
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10725286
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10057418
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.09842200
116ZNF263_19887448_ChIP-Seq_K562_Human1.09788398
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09482747
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09172250
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09156761
120TP53_20018659_ChIP-ChIP_R1E_Mouse1.08394661
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07301562
122SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06844786
123SPI1_23127762_ChIP-Seq_K562_Human1.05450035
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05144451
125P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04992424
126PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04746673
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03683744
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.02917043
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02643898
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02415441
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02367566
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02336003
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01517472
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01516238
135* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01148831
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00702726
137JUN_21703547_ChIP-Seq_K562_Human0.99950498
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.99024811
139ER_23166858_ChIP-Seq_MCF-7_Human0.98812380
140CTCF_26484167_Chip-Seq_Bcells_Mouse0.98530782
141GATA1_19941826_ChIP-Seq_K562_Human0.98344666
142OCT4_19829295_ChIP-Seq_ESCs_Human0.97948438
143JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97407887
144STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96740593
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96419991
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95547045
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.95399240
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92990646
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92838034
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92329316
151RNF2_27304074_Chip-Seq_NSC_Mouse0.92147675
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92036368
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90402086
154ZNF274_21170338_ChIP-Seq_K562_Hela0.89394568
155* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88799242
156MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88515287
157SMAD3_21741376_ChIP-Seq_ESCs_Human0.86140880
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.85643137
159PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85445075
160AR_19668381_ChIP-Seq_PC3_Human0.84855952
161RUNX2_22187159_ChIP-Seq_PCA_Human0.84661519
162STAT3_23295773_ChIP-Seq_U87_Human0.84617812
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83739677
164CBX2_27304074_Chip-Seq_ESCs_Mouse0.82464027
165TCF4_23295773_ChIP-Seq_U87_Human0.81544092
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81470938
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81036121
168SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80063872
169* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79257724
170BP1_19119308_ChIP-ChIP_Hs578T_Human0.77669823
171GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77131247
172RXR_22108803_ChIP-Seq_LS180_Human0.75868214
173CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75644401
174RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74590965
175KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.73681103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.39550206
2MP0003880_abnormal_central_pattern4.56112977
3MP0003635_abnormal_synaptic_transmissio3.73714612
4MP0009046_muscle_twitch3.56187979
5MP0002064_seizures3.41765252
6MP0009745_abnormal_behavioral_response3.36539208
7MP0001968_abnormal_touch/_nociception3.27388323
8MP0002063_abnormal_learning/memory/cond3.02565473
9MP0002822_catalepsy2.94366599
10MP0002736_abnormal_nociception_after2.85326210
11MP0002572_abnormal_emotion/affect_behav2.72914642
12MP0004270_analgesia2.71188527
13MP0001501_abnormal_sleep_pattern2.67013281
14MP0002735_abnormal_chemical_nociception2.58588408
15MP0009840_abnormal_foam_cell2.53635204
16MP0002272_abnormal_nervous_system2.46071435
17MP0002734_abnormal_mechanical_nocicepti2.40003879
18MP0002733_abnormal_thermal_nociception2.11991634
19MP0001970_abnormal_pain_threshold2.08248724
20MP0001440_abnormal_grooming_behavior2.03270716
21MP0003879_abnormal_hair_cell2.03163927
22MP0009278_abnormal_bone_marrow2.02150216
23MP0003183_abnormal_peptide_metabolism2.01293454
24MP0002067_abnormal_sensory_capabilities1.98740774
25MP0001486_abnormal_startle_reflex1.92198508
26MP0003123_paternal_imprinting1.91476508
27MP0004858_abnormal_nervous_system1.90993659
28MP0003705_abnormal_hypodermis_morpholog1.90966013
29MP0010386_abnormal_urinary_bladder1.88477091
30MP0003122_maternal_imprinting1.88294267
31MP0003191_abnormal_cellular_cholesterol1.85470005
32MP0003329_amyloid_beta_deposits1.80875352
33MP0009780_abnormal_chondrocyte_physiolo1.78454394
34MP0005451_abnormal_body_composition1.76578572
35MP0005058_abnormal_lysosome_morphology1.72871554
36MP0005423_abnormal_somatic_nervous1.71732856
37MP0005646_abnormal_pituitary_gland1.70841781
38MP0003172_abnormal_lysosome_physiology1.70273329
39MP0001905_abnormal_dopamine_level1.69285708
40MP0006276_abnormal_autonomic_nervous1.68321032
41MP0001984_abnormal_olfaction1.63505883
42MP0002909_abnormal_adrenal_gland1.59811677
43MP0003787_abnormal_imprinting1.59522646
44MP0000343_altered_response_to1.57052621
45MP0008569_lethality_at_weaning1.55025416
46MP0004924_abnormal_behavior1.54601361
47MP0005386_behavior/neurological_phenoty1.54601361
48MP0001529_abnormal_vocalization1.53770536
49MP0004811_abnormal_neuron_physiology1.53683658
50MP0005025_abnormal_response_to1.52010004
51MP0004142_abnormal_muscle_tone1.47006578
52MP0005464_abnormal_platelet_physiology1.46962669
53MP0003300_gastrointestinal_ulcer1.46403061
54MP0002557_abnormal_social/conspecific_i1.45416634
55MP0002184_abnormal_innervation1.43356075
56MP0000678_abnormal_parathyroid_gland1.43069606
57MP0003453_abnormal_keratinocyte_physiol1.40552212
58MP0005000_abnormal_immune_tolerance1.38756197
59MP0002876_abnormal_thyroid_physiology1.36452406
60MP0001533_abnormal_skeleton_physiology1.36166877
61MP0000604_amyloidosis1.35923632
62MP0005409_darkened_coat_color1.34642302
63MP0005623_abnormal_meninges_morphology1.33723102
64MP0004947_skin_inflammation1.33676462
65MP0001502_abnormal_circadian_rhythm1.33074106
66MP0005645_abnormal_hypothalamus_physiol1.30773396
67MP0003303_peritoneal_inflammation1.29264395
68MP0002066_abnormal_motor_capabilities/c1.28832360
69MP0003075_altered_response_to1.28661502
70MP0003633_abnormal_nervous_system1.28482459
71MP0000858_altered_metastatic_potential1.23003875
72MP0003724_increased_susceptibility_to1.21525571
73MP0002998_abnormal_bone_remodeling1.20439143
74MP0002877_abnormal_melanocyte_morpholog1.18394775
75MP0008260_abnormal_autophagy1.14142124
76MP0001790_abnormal_immune_system1.13810982
77MP0005387_immune_system_phenotype1.13810982
78MP0001348_abnormal_lacrimal_gland1.12277142
79MP0000955_abnormal_spinal_cord1.10835274
80MP0002249_abnormal_larynx_morphology1.09952135
81MP0002882_abnormal_neuron_morphology1.09566678
82MP0000013_abnormal_adipose_tissue1.09437692
83MP0004510_myositis1.07022929
84MP0001849_ear_inflammation1.06931992
85MP0005671_abnormal_response_to1.06208973
86MP0003631_nervous_system_phenotype1.05964219
87MP0005535_abnormal_body_temperature1.04287709
88MP0009785_altered_susceptibility_to1.03860727
89MP0001986_abnormal_taste_sensitivity1.02558838
90MP0004185_abnormal_adipocyte_glucose1.01763872
91MP0004043_abnormal_pH_regulation1.01184375
92MP0005171_absent_coat_pigmentation0.98429715
93MP0000685_abnormal_immune_system0.97937438
94MP0009333_abnormal_splenocyte_physiolog0.97538223
95MP0002229_neurodegeneration0.97033879
96MP0003279_aneurysm0.96965762
97MP0002723_abnormal_immune_serum0.96548918
98MP0002837_dystrophic_cardiac_calcinosis0.93488610
99MP0002638_abnormal_pupillary_reflex0.92693407
100MP0002090_abnormal_vision0.92544982
101MP0002420_abnormal_adaptive_immunity0.92447289
102MP0008872_abnormal_physiological_respon0.92328660
103MP0002069_abnormal_eating/drinking_beha0.91628497
104MP0001819_abnormal_immune_cell0.91042677
105MP0001188_hyperpigmentation0.90655407
106MP0003690_abnormal_glial_cell0.90639010
107MP0001545_abnormal_hematopoietic_system0.89975220
108MP0005397_hematopoietic_system_phenotyp0.89975220
109MP0003646_muscle_fatigue0.89897834
110MP0002089_abnormal_postnatal_growth/wei0.89796295
111MP0000751_myopathy0.88999356
112MP0003634_abnormal_glial_cell0.87035260
113MP0002452_abnormal_antigen_presenting0.86237702
114MP0005076_abnormal_cell_differentiation0.85758480
115MP0008874_decreased_physiological_sensi0.85515114
116MP0005083_abnormal_biliary_tract0.85187128
117MP0000778_abnormal_nervous_system0.84962399
118MP0002332_abnormal_exercise_endurance0.84661782
119MP0006082_CNS_inflammation0.83276602
120MP0005666_abnormal_adipose_tissue0.82619713
121MP0005310_abnormal_salivary_gland0.81990848
122MP0001542_abnormal_bone_strength0.78392270
123MP0004130_abnormal_muscle_cell0.76914913
124MP0005390_skeleton_phenotype0.76706527
125MP0001963_abnormal_hearing_physiology0.76604990
126MP0001835_abnormal_antigen_presentation0.75943889
127MP0002796_impaired_skin_barrier0.72532629
128MP0005375_adipose_tissue_phenotype0.72434163
129MP0001845_abnormal_inflammatory_respons0.71400517
130MP0003632_abnormal_nervous_system0.71155648
131MP0001664_abnormal_digestion0.69703871
132MP0005167_abnormal_blood-brain_barrier0.69187660
133MP0004742_abnormal_vestibular_system0.68320543
134MP0005551_abnormal_eye_electrophysiolog0.67777179
135MP0001800_abnormal_humoral_immune0.67639539
136MP0005166_decreased_susceptibility_to0.65096668
137MP0002148_abnormal_hypersensitivity_rea0.63366104
138MP0002152_abnormal_brain_morphology0.63318842
139MP0000681_abnormal_thyroid_gland0.62889561
140MP0004885_abnormal_endolymph0.59281251
141MP0008004_abnormal_stomach_pH0.55730012
142MP0005448_abnormal_energy_balance0.55542584
143MP0002419_abnormal_innate_immunity0.54439912
144MP0004484_altered_response_of0.53884621
145MP0003436_decreased_susceptibility_to0.53683806
146MP0008961_abnormal_basal_metabolism0.52648871
147MP0003195_calcinosis0.52602304
148MP0002653_abnormal_ependyma_morphology0.52504150
149MP0000920_abnormal_myelination0.51243677
150MP0001765_abnormal_ion_homeostasis0.50327798

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.32296372
2Myokymia (HP:0002411)5.52519153
3Atonic seizures (HP:0010819)5.38562637
4Epileptic encephalopathy (HP:0200134)5.15941468
5Focal seizures (HP:0007359)4.78804563
6Febrile seizures (HP:0002373)4.60770758
7Visual hallucinations (HP:0002367)4.47775677
8Absence seizures (HP:0002121)4.30984895
9Dialeptic seizures (HP:0011146)4.01594108
10Neurofibrillary tangles (HP:0002185)4.01046080
11Generalized tonic-clonic seizures (HP:0002069)3.78316939
12Polyphagia (HP:0002591)3.73046071
13Failure to thrive in infancy (HP:0001531)3.63480795
14Pheochromocytoma (HP:0002666)3.62862661
15Abnormal eating behavior (HP:0100738)3.51442012
16Neuroendocrine neoplasm (HP:0100634)3.47874550
17Cerebral inclusion bodies (HP:0100314)3.47477506
18Progressive cerebellar ataxia (HP:0002073)3.43275220
19Obstructive sleep apnea (HP:0002870)3.42180404
20Abnormal hair whorl (HP:0010721)3.40449064
21Hyperventilation (HP:0002883)3.38547379
22Increased cerebral lipofuscin (HP:0011813)3.34397917
23Abnormality of macrophages (HP:0004311)3.01066505
24Increased neuronal autofluorescent lipopigment (HP:0002074)2.96307979
25Abnormality of glycolipid metabolism (HP:0010969)2.92745322
26Abnormality of liposaccharide metabolism (HP:0010968)2.92745322
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.92745322
28Axonal loss (HP:0003447)2.92408110
29Supranuclear gaze palsy (HP:0000605)2.90906376
30Purpura (HP:0000979)2.87898304
31Loss of speech (HP:0002371)2.87081501
32Eczematoid dermatitis (HP:0000976)2.84151779
33Mutism (HP:0002300)2.80412004
34Apathy (HP:0000741)2.77292303
35Oligomenorrhea (HP:0000876)2.77128371
36Diplopia (HP:0000651)2.76518011
37Abnormality of binocular vision (HP:0011514)2.76518011
38Poor suck (HP:0002033)2.76012039
39Diminished motivation (HP:0000745)2.69917165
40Limb dystonia (HP:0002451)2.68719313
41Depression (HP:0000716)2.67086861
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.61932254
43Progressive inability to walk (HP:0002505)2.59975076
44Dysostosis multiplex (HP:0000943)2.57697411
45Abnormal mitochondria in muscle tissue (HP:0008316)2.54866729
46Systemic lupus erythematosus (HP:0002725)2.54681327
47Achilles tendon contracture (HP:0001771)2.51551647
48Anxiety (HP:0000739)2.49791464
49Nuclear cataract (HP:0100018)2.49662219
50Acute necrotizing encephalopathy (HP:0006965)2.49031313
51Epileptiform EEG discharges (HP:0011182)2.47573152
52Gaze-evoked nystagmus (HP:0000640)2.42137926
53Hyperparathyroidism (HP:0000843)2.40472181
54Annular pancreas (HP:0001734)2.40287475
55Chronic obstructive pulmonary disease (HP:0006510)2.39633627
56Obstructive lung disease (HP:0006536)2.39633627
57Peripheral hypomyelination (HP:0007182)2.39302752
58Broad-based gait (HP:0002136)2.35353496
59Hyperthyroidism (HP:0000836)2.35034102
60Gait imbalance (HP:0002141)2.32078258
61Upper limb amyotrophy (HP:0009129)2.31587198
62Distal upper limb amyotrophy (HP:0007149)2.31587198
63Vertebral compression fractures (HP:0002953)2.31423549
64Action tremor (HP:0002345)2.30284919
65Amblyopia (HP:0000646)2.28949588
66Dysdiadochokinesis (HP:0002075)2.26703996
67Neuronal loss in central nervous system (HP:0002529)2.26400053
68Poor eye contact (HP:0000817)2.25914068
69Abnormality of the Achilles tendon (HP:0005109)2.23417357
70EEG with generalized epileptiform discharges (HP:0011198)2.23091128
71Petechiae (HP:0000967)2.22552913
72Amyloidosis (HP:0011034)2.22374264
73Disinhibition (HP:0000734)2.21570648
74Bradykinesia (HP:0002067)2.21180682
75Truncal ataxia (HP:0002078)2.21179916
76Hypoventilation (HP:0002791)2.20093543
77Dysmetria (HP:0001310)2.18105171
78Nephrogenic diabetes insipidus (HP:0009806)2.18051864
79Congenital primary aphakia (HP:0007707)2.17397650
80Resting tremor (HP:0002322)2.15503488
81Ankle clonus (HP:0011448)2.15037056
82Recurrent abscess formation (HP:0002722)2.12314655
83Postural instability (HP:0002172)2.12086827
84Status epilepticus (HP:0002133)2.12077186
85Inability to walk (HP:0002540)2.11500791
86Neoplasm of the peripheral nervous system (HP:0100007)2.11415066
87Impaired social interactions (HP:0000735)2.11136987
88Abnormal social behavior (HP:0012433)2.11136987
89Slow saccadic eye movements (HP:0000514)2.10481642
90Mitochondrial inheritance (HP:0001427)2.09780941
91Impaired vibration sensation in the lower limbs (HP:0002166)2.08567668
92Medial flaring of the eyebrow (HP:0010747)2.08216963
93Hypsarrhythmia (HP:0002521)2.07390281
94Progressive macrocephaly (HP:0004481)2.06628573
95Psychosis (HP:0000709)2.06405508
96Hyperacusis (HP:0010780)2.05853998
97Generalized myoclonic seizures (HP:0002123)2.05230423
98Torticollis (HP:0000473)2.04865900
99Craniofacial dystonia (HP:0012179)2.03614516
100Stridor (HP:0010307)2.03155032
101Distal lower limb muscle weakness (HP:0009053)2.01430499
102Focal dystonia (HP:0004373)2.01423549
103Tetraplegia (HP:0002445)2.00426378
104Vacuolated lymphocytes (HP:0001922)1.99050090
105Hypercortisolism (HP:0001578)1.99028522
106Mediastinal lymphadenopathy (HP:0100721)1.97773085
107Hypothermia (HP:0002045)1.97618326
108Urinary glycosaminoglycan excretion (HP:0003541)1.97266341
109Mucopolysacchariduria (HP:0008155)1.97266341
110Rapidly progressive (HP:0003678)1.95429776
111J-shaped sella turcica (HP:0002680)1.94835004
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94555103
113Increased IgE level (HP:0003212)1.93551497
114Abnormal gallbladder physiology (HP:0012438)1.93341757
115Cholecystitis (HP:0001082)1.93341757
116Hand muscle atrophy (HP:0009130)1.93272510
117Cellulitis (HP:0100658)1.93096426
118Hip dysplasia (HP:0001385)1.93091846
119Insomnia (HP:0100785)1.92951770
120Delusions (HP:0000746)1.92281863
121Hepatocellular necrosis (HP:0001404)1.92055457
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91547183
123Abnormality of polysaccharide metabolism (HP:0011012)1.91547183
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91547183
125Rigidity (HP:0002063)1.91040169
126Specific learning disability (HP:0001328)1.90734383
127Polygenic inheritance (HP:0010982)1.90678092
128Fetal akinesia sequence (HP:0001989)1.89777146
129Esotropia (HP:0000565)1.88673085
130Spinal canal stenosis (HP:0003416)1.88491946
131Bulbar palsy (HP:0001283)1.88274234
132Iris hypopigmentation (HP:0007730)1.88196861
133Progressive neurologic deterioration (HP:0002344)1.86619786
134Agitation (HP:0000713)1.86334374
135Dementia (HP:0000726)1.86192298
136Recurrent bacterial skin infections (HP:0005406)1.84875599
137Cerebral aneurysm (HP:0004944)1.84416106
138Recurrent gram-negative bacterial infections (HP:0005420)1.82778564
139Urinary bladder sphincter dysfunction (HP:0002839)1.82391127
140Segmental peripheral demyelination/remyelination (HP:0003481)1.82123867
141Myoclonus (HP:0001336)1.82033357
142Esophageal neoplasm (HP:0100751)1.81369021
143Neoplasm of head and neck (HP:0012288)1.81369021
144Cortical visual impairment (HP:0100704)1.80865219
145Generalized hypopigmentation (HP:0007513)1.80831228
146Upper motor neuron abnormality (HP:0002127)1.80168886
147Pathologic fracture (HP:0002756)1.78777722
148Increased serum ferritin (HP:0003281)1.76894324
149Distal lower limb amyotrophy (HP:0008944)1.76323797
150Ocular albinism (HP:0001107)1.75465438
151Abnormality of the nasal mucosa (HP:0000433)1.75237028
152Growth hormone excess (HP:0000845)1.74672715
153Long palpebral fissure (HP:0000637)1.73526357
154Hypertensive crisis (HP:0100735)1.72630315
155Personality changes (HP:0000751)1.72562897
156Truncus arteriosus (HP:0001660)1.71428248
157Urticaria (HP:0001025)1.70332160
158Myositis (HP:0100614)1.69743567
159Genu recurvatum (HP:0002816)1.66744649
160Spastic gait (HP:0002064)1.65485902
161Lower limb amyotrophy (HP:0007210)1.65348329
162Prolonged neonatal jaundice (HP:0006579)1.65244505
163Urinary incontinence (HP:0000020)1.63926824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.35014804
2MAP3K124.26154910
3NTRK33.75639554
4EPHA43.12367234
5MAP3K93.08953595
6TRIB32.99364058
7RIPK42.98405293
8ERN12.88126490
9ARAF2.87475819
10DAPK22.78428219
11MAP2K72.73936792
12MAP3K42.57125436
13DAPK12.50189566
14CDK192.43168780
15PLK22.35855836
16TAOK22.12545530
17MINK12.11092497
18SIK12.05301832
19IRAK32.02999498
20PRPF4B1.98631431
21NME21.93457000
22ICK1.85616184
23RIPK11.80588514
24GRK51.79981031
25TESK21.75453384
26CAMKK21.69998401
27KSR21.66676310
28SMG11.65448918
29MAP2K31.64268456
30MAP2K41.63490577
31CCNB11.61433974
32AKT31.55163601
33SIK31.54626071
34MARK21.51433032
35PAK61.44063895
36CAMKK11.40813060
37BRAF1.40510287
38TSSK61.38838649
39PRKCG1.33328931
40MAP3K31.32729664
41NTRK11.28599116
42MAP4K11.26380873
43FES1.23993241
44NTRK21.21013674
45CDK51.20636292
46MAP3K131.19485957
47OXSR11.17897290
48MARK11.11355333
49NME11.10604234
50PRKD21.07379448
51TBK11.05140978
52BMPR21.01754405
53TYRO30.98978563
54MAPK120.97658295
55CAMK2A0.96955087
56GRK60.95790649
57DAPK30.95731214
58CDK120.92874560
59PTK2B0.91077686
60KSR10.89708449
61IRAK40.89319897
62CDC42BPA0.88138362
63CDK180.86949418
64SGK2230.86097381
65SGK4940.86097381
66GRK70.85737624
67IRAK20.84749078
68CDK140.83474601
69NEK10.82828175
70MAP3K10.82681947
71HIPK20.82620515
72CAMK2B0.82400063
73ZAP700.81100288
74CDK150.79543789
75EPHB10.78181192
76SGK20.78054862
77CSK0.77001521
78MAP3K20.75840898
79LATS20.75121432
80PRKCE0.74648639
81DDR20.71515622
82FGR0.70544027
83CDK11A0.69106160
84PRKG20.67832243
85ADRBK20.67604027
86CAMK1D0.67507220
87PRKCH0.67163550
88STK380.65565310
89DYRK1B0.65265668
90MAPK130.64596480
91RPS6KL10.64212815
92RPS6KC10.64212815
93MAP2K20.63140814
94SIK20.62876569
95UHMK10.60675087
96RAF10.60345098
97MYLK0.60190875
98TESK10.59819295
99CAMK2G0.59002705
100PTK60.58613036
101CAMK10.58285098
102SGK30.57771745
103SYK0.56987919
104PDPK10.56985119
105TYK20.56973374
106LMTK20.56271667
107WNK30.55697764
108MAP3K110.55263615
109STK110.54965296
110CAMK2D0.53466180
111ALK0.53221594
112PRKD30.52903467
113PKN20.52756897
114PINK10.52358730
115PIM20.51929220
116TNIK0.51840168
117EEF2K0.51771141
118TAOK10.51092395
119PDK10.50702003
120PDK20.49774062
121DMPK0.48661612
122PDK40.47531545
123PDK30.47531545
124MAP2K10.46411791
125PTK20.46292484
126BMX0.46164413
127ADRBK10.45359053
128RPS6KA60.45060807
129LIMK10.44301183
130MAPK40.43936392
131SCYL20.42419563
132LRRK20.41792784
133RPS6KA20.41015841
134MOS0.40702005
135SGK10.40152710
136MATK0.37353444
137PAK10.37265143
138BLK0.37062942
139DYRK1A0.32592261
140TNK20.32120002
141CSNK1G20.31764143
142MAP3K140.31322744
143PRKCA0.31042049
144FER0.30817297
145PRKCD0.30293573
146ABL20.28188894
147FYN0.28025495
148ERBB40.27730896
149CAMK40.27709499

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047214.80843385
2* Collecting duct acid secretion_Homo sapiens_hsa049664.01182107
3Nicotine addiction_Homo sapiens_hsa050333.50635547
4* Vibrio cholerae infection_Homo sapiens_hsa051102.75517899
5GABAergic synapse_Homo sapiens_hsa047272.46360882
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40215659
7Olfactory transduction_Homo sapiens_hsa047402.34483278
8Morphine addiction_Homo sapiens_hsa050322.23654825
9Circadian entrainment_Homo sapiens_hsa047132.16868751
10* Oxidative phosphorylation_Homo sapiens_hsa001902.03728517
11Long-term potentiation_Homo sapiens_hsa047202.01871956
12Amphetamine addiction_Homo sapiens_hsa050312.01780438
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99480721
14* Rheumatoid arthritis_Homo sapiens_hsa053231.94484140
15* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.88764270
16Glutamatergic synapse_Homo sapiens_hsa047241.82371095
17Dopaminergic synapse_Homo sapiens_hsa047281.80189477
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73932741
19Insulin secretion_Homo sapiens_hsa049111.71565809
20VEGF signaling pathway_Homo sapiens_hsa043701.68912110
21* Phagosome_Homo sapiens_hsa041451.62354132
22Salivary secretion_Homo sapiens_hsa049701.57581336
23Taste transduction_Homo sapiens_hsa047421.57243406
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50037064
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47772060
26Serotonergic synapse_Homo sapiens_hsa047261.47454378
27Cocaine addiction_Homo sapiens_hsa050301.44405939
28Cholinergic synapse_Homo sapiens_hsa047251.44126793
29Type I diabetes mellitus_Homo sapiens_hsa049401.43178457
30* Lysosome_Homo sapiens_hsa041421.41526819
31B cell receptor signaling pathway_Homo sapiens_hsa046621.41014350
32Long-term depression_Homo sapiens_hsa047301.37550918
33Acute myeloid leukemia_Homo sapiens_hsa052211.33076576
34Parkinsons disease_Homo sapiens_hsa050121.31535771
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29432037
36Notch signaling pathway_Homo sapiens_hsa043301.28549502
37Gastric acid secretion_Homo sapiens_hsa049711.27028754
38Calcium signaling pathway_Homo sapiens_hsa040201.20476765
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19951409
40Alzheimers disease_Homo sapiens_hsa050101.18391861
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16522747
42Bladder cancer_Homo sapiens_hsa052191.14551337
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12301044
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12201157
45Renin secretion_Homo sapiens_hsa049241.10046329
46Malaria_Homo sapiens_hsa051441.08378774
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07611984
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06533146
49Non-small cell lung cancer_Homo sapiens_hsa052231.04730834
50Oxytocin signaling pathway_Homo sapiens_hsa049211.02757358
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98150446
52Chronic myeloid leukemia_Homo sapiens_hsa052200.97718425
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97543470
54Staphylococcus aureus infection_Homo sapiens_hsa051500.93206191
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91612822
56Gap junction_Homo sapiens_hsa045400.88133380
57Cardiac muscle contraction_Homo sapiens_hsa042600.85874293
58TNF signaling pathway_Homo sapiens_hsa046680.85722060
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85031320
60Type II diabetes mellitus_Homo sapiens_hsa049300.84727192
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84407272
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84269914
63Renal cell carcinoma_Homo sapiens_hsa052110.83905036
64GnRH signaling pathway_Homo sapiens_hsa049120.82967570
65Amoebiasis_Homo sapiens_hsa051460.82948256
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81618369
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81345131
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81304005
69* Tuberculosis_Homo sapiens_hsa051520.80727177
70cAMP signaling pathway_Homo sapiens_hsa040240.80025464
71Other glycan degradation_Homo sapiens_hsa005110.78881156
72Huntingtons disease_Homo sapiens_hsa050160.76386399
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75066716
74Endometrial cancer_Homo sapiens_hsa052130.74029729
75Pancreatic cancer_Homo sapiens_hsa052120.72818980
76Sulfur relay system_Homo sapiens_hsa041220.70901624
77Hepatitis C_Homo sapiens_hsa051600.70574547
78mTOR signaling pathway_Homo sapiens_hsa041500.70182940
79Toxoplasmosis_Homo sapiens_hsa051450.70012838
80Insulin signaling pathway_Homo sapiens_hsa049100.69718521
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.67271847
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.65460403
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.64572684
84Rap1 signaling pathway_Homo sapiens_hsa040150.64414894
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64062911
86T cell receptor signaling pathway_Homo sapiens_hsa046600.63828115
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63571285
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63261137
89Choline metabolism in cancer_Homo sapiens_hsa052310.63062315
90Estrogen signaling pathway_Homo sapiens_hsa049150.63032020
91Phototransduction_Homo sapiens_hsa047440.62503274
92Regulation of autophagy_Homo sapiens_hsa041400.61560593
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.60960151
94Pentose phosphate pathway_Homo sapiens_hsa000300.60282254
95Apoptosis_Homo sapiens_hsa042100.59815142
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58634360
97Glioma_Homo sapiens_hsa052140.56969143
98Salmonella infection_Homo sapiens_hsa051320.56626147
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55010259
100ErbB signaling pathway_Homo sapiens_hsa040120.54158722
101Prolactin signaling pathway_Homo sapiens_hsa049170.54138016
102Prion diseases_Homo sapiens_hsa050200.52732359
103African trypanosomiasis_Homo sapiens_hsa051430.50568241
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.49954539
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49369210
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48492322
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.47645562
108Chemokine signaling pathway_Homo sapiens_hsa040620.46144295
109Endocytosis_Homo sapiens_hsa041440.45435252
110Melanogenesis_Homo sapiens_hsa049160.44929220
111Fructose and mannose metabolism_Homo sapiens_hsa000510.44606834
112MAPK signaling pathway_Homo sapiens_hsa040100.43820615
113Pancreatic secretion_Homo sapiens_hsa049720.42286948
114Pertussis_Homo sapiens_hsa051330.41369751
115Thyroid hormone synthesis_Homo sapiens_hsa049180.41003280
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39575730
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36473682
118Legionellosis_Homo sapiens_hsa051340.36278981
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34742318
120Leishmaniasis_Homo sapiens_hsa051400.31971697
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.30942815
122Galactose metabolism_Homo sapiens_hsa000520.30492692
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30159156
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.30007571
125Mineral absorption_Homo sapiens_hsa049780.28844880
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27324050
127Asthma_Homo sapiens_hsa053100.26237227
128Axon guidance_Homo sapiens_hsa043600.25617911
129Oocyte meiosis_Homo sapiens_hsa041140.25164012
130Dilated cardiomyopathy_Homo sapiens_hsa054140.24862546
131Shigellosis_Homo sapiens_hsa051310.24737529
132Ras signaling pathway_Homo sapiens_hsa040140.24248222
133Inositol phosphate metabolism_Homo sapiens_hsa005620.23820374
134Osteoclast differentiation_Homo sapiens_hsa043800.23818558
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23209482
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22538611

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