ATP6V0D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.44503966
2synaptic vesicle exocytosis (GO:0016079)5.43036321
3synaptic vesicle maturation (GO:0016188)5.14468264
4neutrophil activation involved in immune response (GO:0002283)4.90638125
5glutamate secretion (GO:0014047)4.84901068
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80254254
7regulation of synaptic vesicle exocytosis (GO:2000300)4.79214097
8locomotory exploration behavior (GO:0035641)4.39280063
9regulation of synaptic vesicle transport (GO:1902803)4.23952761
10vocalization behavior (GO:0071625)4.18233481
11neurotransmitter secretion (GO:0007269)4.08721576
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.05506432
13macrophage activation involved in immune response (GO:0002281)4.04910987
14proline transport (GO:0015824)4.00431758
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.98414176
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.97643955
17response to peptidoglycan (GO:0032494)3.92331101
18neuronal action potential propagation (GO:0019227)3.91120663
19neuron cell-cell adhesion (GO:0007158)3.89820265
20regulation of glutamate receptor signaling pathway (GO:1900449)3.88543805
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.77895041
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.77895041
23modulation by symbiont of host immune response (GO:0052553)3.77895041
24positive regulation by symbiont of host defense response (GO:0052509)3.77895041
25modulation by symbiont of host defense response (GO:0052031)3.77895041
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.77895041
27protein localization to synapse (GO:0035418)3.77180299
28exploration behavior (GO:0035640)3.68711813
29layer formation in cerebral cortex (GO:0021819)3.68572630
30negative regulation of interleukin-12 production (GO:0032695)3.67232672
31* transferrin transport (GO:0033572)3.65685002
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62904160
33glycosphingolipid catabolic process (GO:0046479)3.60518656
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.57223094
35* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.56436669
36* ATP hydrolysis coupled proton transport (GO:0015991)3.56436669
37detection of other organism (GO:0098543)3.55506025
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54669598
39negative regulation of cell killing (GO:0031342)3.54669598
40granulocyte activation (GO:0036230)3.53300604
41regulation of neuronal synaptic plasticity (GO:0048168)3.49008700
42regulation of synapse structural plasticity (GO:0051823)3.47495611
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46043794
44amino sugar catabolic process (GO:0046348)3.44830215
45immunoglobulin mediated immune response (GO:0016064)3.43270931
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.40085829
47* trivalent inorganic cation transport (GO:0072512)3.39720384
48* ferric iron transport (GO:0015682)3.39720384
49detection of bacterium (GO:0016045)3.39051819
50neuromuscular process controlling posture (GO:0050884)3.36210254
51regulation of mast cell degranulation (GO:0043304)3.35468892
52neutrophil activation (GO:0042119)3.35274894
53gamma-aminobutyric acid transport (GO:0015812)3.34910599
54glycolipid catabolic process (GO:0019377)3.29365874
55neurotransmitter transport (GO:0006836)3.26230349
56cellular potassium ion homeostasis (GO:0030007)3.25334460
57glutamate receptor signaling pathway (GO:0007215)3.24825055
58respiratory burst (GO:0045730)3.17254565
59cerebellar Purkinje cell layer development (GO:0021680)3.15850132
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15246224
61* phagosome maturation (GO:0090382)3.14833773
62neuron recognition (GO:0008038)3.14146112
63regulation of leukocyte degranulation (GO:0043300)3.13004179
64neuron-neuron synaptic transmission (GO:0007270)3.11908425
65regulation of vesicle fusion (GO:0031338)3.11568452
66synaptic transmission, glutamatergic (GO:0035249)3.10843132
67activation of protein kinase A activity (GO:0034199)3.09527585
68synaptic vesicle endocytosis (GO:0048488)3.07693836
69lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07639105
70sodium ion export (GO:0071436)3.05346806
71detection of external biotic stimulus (GO:0098581)3.05233784
72regulation of interferon-beta biosynthetic process (GO:0045357)3.04965010
73regulation of mast cell activation involved in immune response (GO:0033006)3.04436850
74antigen processing and presentation of endogenous antigen (GO:0019883)3.03634345
75regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03403870
76regulation of neurotransmitter levels (GO:0001505)3.03212279
77oligosaccharide catabolic process (GO:0009313)3.01724799
78positive regulation of gamma-delta T cell activation (GO:0046645)3.00952801
79macrophage activation (GO:0042116)3.00952272
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99989322
81gamma-aminobutyric acid signaling pathway (GO:0007214)2.99001294
82positive regulation of mast cell activation (GO:0033005)2.97101885
83positive regulation of mast cell degranulation (GO:0043306)2.96924410
84positive regulation of mast cell activation involved in immune response (GO:0033008)2.96924410
85regulation of synaptic plasticity (GO:0048167)2.96499862
86regulation of neurotransmitter secretion (GO:0046928)2.96294727
87negative regulation of amino acid transport (GO:0051956)2.95769144
88myeloid cell activation involved in immune response (GO:0002275)2.95477171
89positive regulation of monocyte chemotaxis (GO:0090026)2.95267381
90long-term synaptic potentiation (GO:0060291)2.95007253
91dendritic spine morphogenesis (GO:0060997)2.94798340
92regulation of regulated secretory pathway (GO:1903305)2.94531882
93synaptic vesicle transport (GO:0048489)2.93930342
94establishment of synaptic vesicle localization (GO:0097480)2.93930342
95ceramide catabolic process (GO:0046514)2.93538694
96vesicle transport along microtubule (GO:0047496)2.91828281
97positive regulation of synapse maturation (GO:0090129)2.91774290
98regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91001322
99neurotransmitter-gated ion channel clustering (GO:0072578)2.90791341
100alanine transport (GO:0032328)2.90076517
101axonal fasciculation (GO:0007413)2.89590582
102detection of molecule of bacterial origin (GO:0032490)2.89300187
103negative regulation of microtubule polymerization (GO:0031115)2.89015960
104G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88904882
105mating behavior (GO:0007617)2.87932386
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87871190
107barbed-end actin filament capping (GO:0051016)2.87822165
108neuromuscular process controlling balance (GO:0050885)2.85937990
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85592865
110positive regulation of leukocyte degranulation (GO:0043302)2.84053314
111regulation of clathrin-mediated endocytosis (GO:2000369)2.83406870
112regulation of early endosome to late endosome transport (GO:2000641)2.83037970
113positive regulation of vesicle fusion (GO:0031340)2.82645659
114positive regulation of exocytosis (GO:0045921)2.79823221
115positive regulation of membrane potential (GO:0045838)2.79814454
116regulation of postsynaptic membrane potential (GO:0060078)2.79060100
117cellular extravasation (GO:0045123)2.77252273
118long-term memory (GO:0007616)2.76601176
119positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76438130
120response to histamine (GO:0034776)2.75492221
121regulation of neurotransmitter transport (GO:0051588)2.74856104
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74696088
123clathrin coat assembly (GO:0048268)2.72711450
124establishment of vesicle localization (GO:0051650)2.72294596
125NIK/NF-kappaB signaling (GO:0038061)2.72078166
126N-acetylneuraminate metabolic process (GO:0006054)2.71684271
127antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70973230
128leukocyte aggregation (GO:0070486)2.70853829
129regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69948138
130regulation of amyloid precursor protein catabolic process (GO:1902991)2.69838478
131interferon-gamma-mediated signaling pathway (GO:0060333)2.69375939
132protein localization to endosome (GO:0036010)2.69101700
133regulation of exocytosis (GO:0017157)2.68703479
134positive regulation of regulated secretory pathway (GO:1903307)2.67716467
135regulation of glutamate secretion (GO:0014048)2.67632206
136cerebellar Purkinje cell differentiation (GO:0021702)2.67339476
137positive regulation of cellular amide metabolic process (GO:0034250)2.66595287
138organelle transport along microtubule (GO:0072384)2.65757254
139positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.64052671
140amyloid precursor protein catabolic process (GO:0042987)2.64017869
141regulation of T-helper 2 cell differentiation (GO:0045628)2.62985540
142regulation of mast cell activation (GO:0033003)2.62938428
143hydrogen peroxide biosynthetic process (GO:0050665)2.62543170
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61566552
145Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60781475
146microglial cell activation (GO:0001774)2.60362301
147cell migration in hindbrain (GO:0021535)2.60080471
148sphingolipid catabolic process (GO:0030149)2.60008483
149signal release (GO:0023061)2.59156831
150axon cargo transport (GO:0008088)2.57988348
151cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57980478
152glycine transport (GO:0015816)2.57913805
153membrane lipid catabolic process (GO:0046466)2.57678232
154innervation (GO:0060384)2.56990383
155eosinophil chemotaxis (GO:0048245)2.56257693
156cellular response to thyroid hormone stimulus (GO:0097067)2.56015800
157dendrite morphogenesis (GO:0048813)2.55988838
158regulation of ARF protein signal transduction (GO:0032012)2.55964411
159regulation of synaptic transmission, glutamatergic (GO:0051966)2.55249952
160positive regulation of synaptic transmission (GO:0050806)2.55131395
161detection of biotic stimulus (GO:0009595)2.55055338
162regulation of mononuclear cell migration (GO:0071675)2.55010644
163regulation of superoxide anion generation (GO:0032928)2.54017128
164positive regulation of neurotransmitter transport (GO:0051590)2.53493392
165prepulse inhibition (GO:0060134)2.53423109
166regulation of synaptic transmission (GO:0050804)2.53223639
167negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.52887808
168positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51810079
169synaptic transmission (GO:0007268)2.51524562
170production of molecular mediator involved in inflammatory response (GO:0002532)2.51106064
171negative regulation of cytokine production involved in immune response (GO:0002719)2.49124701
172regulation of monocyte chemotaxis (GO:0090025)2.47398830
173response to host immune response (GO:0052572)2.45946531
174response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45946531
175type I interferon signaling pathway (GO:0060337)2.42675911
176cellular response to type I interferon (GO:0071357)2.42675911
177positive regulation of antigen processing and presentation (GO:0002579)2.37814836
178response to type I interferon (GO:0034340)2.36059121
179neutrophil chemotaxis (GO:0030593)2.34583698
180cellular response to arsenic-containing substance (GO:0071243)2.33191924
181myeloid leukocyte activation (GO:0002274)2.32685060
182germinal center formation (GO:0002467)2.32242978
183positive regulation of toll-like receptor signaling pathway (GO:0034123)2.32213148
184regulation of antigen processing and presentation (GO:0002577)2.31591624
185B cell mediated immunity (GO:0019724)2.30829394
186neutrophil mediated immunity (GO:0002446)2.30591076
187reactive oxygen species biosynthetic process (GO:1903409)2.30098335
188eosinophil migration (GO:0072677)2.29503773
189negative regulation of interleukin-6 production (GO:0032715)2.28716125
190myeloid dendritic cell differentiation (GO:0043011)2.28200626
191neutrophil migration (GO:1990266)2.27988364
192response to thyroid hormone (GO:0097066)2.27751317
193leukocyte migration involved in inflammatory response (GO:0002523)2.27332933
194regulation of macrophage chemotaxis (GO:0010758)2.27202791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17761905
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.35690986
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.97400575
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.78502425
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.15722391
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96117196
7REST_21632747_ChIP-Seq_MESCs_Mouse2.78226803
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77931861
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.73399514
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72969698
11GBX2_23144817_ChIP-Seq_PC3_Human2.64182866
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64028204
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61931183
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59815530
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.53906415
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.52459089
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51190444
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49901517
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49412699
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44907472
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43520780
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43520780
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42676770
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.39926497
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38231313
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38140034
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32594904
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31665417
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14587758
30SPI1_23127762_ChIP-Seq_K562_Human2.14573414
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.12350671
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04884906
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.03910180
34DROSHA_22980978_ChIP-Seq_HELA_Human2.03878994
35MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01173977
36VDR_24763502_ChIP-Seq_THP-1_Human2.01070364
37EZH2_27294783_Chip-Seq_ESCs_Mouse2.01067301
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93110253
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.93014678
40VDR_21846776_ChIP-Seq_THP-1_Human1.92939825
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91475706
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88313277
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.87613750
44* SPI1_23547873_ChIP-Seq_NB4_Human1.87024619
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85283383
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79251043
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78095254
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77854456
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75023839
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74470690
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.73375900
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72438795
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69668609
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69516155
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69144394
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.61105552
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59607942
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59110602
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.57067866
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55000375
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53786665
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52464788
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51361299
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49680435
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.48860478
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47515797
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45769891
68BCL6_27268052_Chip-Seq_Bcells_Human1.45610223
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45266902
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42281441
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41693865
72* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40238349
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40214433
74BCOR_27268052_Chip-Seq_Bcells_Human1.39143522
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.38677269
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38642673
77* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38235718
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35720295
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35034728
80KDM2B_26808549_Chip-Seq_K562_Human1.34866960
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33680959
82AR_21572438_ChIP-Seq_LNCaP_Human1.33322233
83VDR_24787735_ChIP-Seq_THP-1_Human1.33028200
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31863133
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31839401
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31552989
87MAF_26560356_Chip-Seq_TH1_Human1.31433097
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31211424
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30194507
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30160210
91UTX_26944678_Chip-Seq_JUKART_Human1.28521348
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24882663
93SMAD4_21799915_ChIP-Seq_A2780_Human1.24448822
94ZNF274_21170338_ChIP-Seq_K562_Hela1.24435889
95KDM2B_26808549_Chip-Seq_DND41_Human1.21031993
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20482269
97RACK7_27058665_Chip-Seq_MCF-7_Human1.19796174
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18295165
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17902193
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17881412
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16367861
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14203609
103SCL_19346495_ChIP-Seq_HPC-7_Human1.13811478
104* TFEB_21752829_ChIP-Seq_HELA_Human1.13765398
105STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13551385
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.13326028
107AR_25329375_ChIP-Seq_VCAP_Human1.12260515
108TAF15_26573619_Chip-Seq_HEK293_Human1.11500113
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10818036
110P68_20966046_ChIP-Seq_HELA_Human1.10796484
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.10165327
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.09619075
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09105828
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08927164
115GATA1_19941826_ChIP-Seq_K562_Human1.08885858
116LXR_22292898_ChIP-Seq_THP-1_Human1.08858063
117MAF_26560356_Chip-Seq_TH2_Human1.07914329
118TCF7_22412390_ChIP-Seq_EML_Mouse1.07830072
119RXR_22158963_ChIP-Seq_LIVER_Mouse1.07236719
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06968955
121RUNX_20019798_ChIP-Seq_JUKART_Human1.05469692
122ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04819437
123PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04230479
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04165173
125SA1_27219007_Chip-Seq_Bcells_Human1.03282430
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01919928
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01695805
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01695805
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.01666747
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00395108
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00297082
132* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99128001
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98907191
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98722346
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98709143
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98699564
137SA1_27219007_Chip-Seq_ERYTHROID_Human0.98448706
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97607752
139ZNF263_19887448_ChIP-Seq_K562_Human0.97492880
140SMC4_20622854_ChIP-Seq_HELA_Human0.97342355
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97312987
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97077869
143IGF1R_20145208_ChIP-Seq_DFB_Human0.96943353
144AR_19668381_ChIP-Seq_PC3_Human0.96326958
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95620708
146* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95591296
147P300_19829295_ChIP-Seq_ESCs_Human0.95289757
148STAT1_20625510_ChIP-Seq_HELA_Human0.95251691
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95203562
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.94307361
151ESR2_21235772_ChIP-Seq_MCF-7_Human0.94150962
152* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93967070
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93884198
154TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92315514
155* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92079650
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.91770467
157NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91533854
158SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91500648
159* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90811858
160AHR_22903824_ChIP-Seq_MCF-7_Human0.90716841
161* RXR_22108803_ChIP-Seq_LS180_Human0.90152833
162* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90050464
163TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90035967
164VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89988845
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89027192
166CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87962439
167KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87269296
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86838807
169RING1B_27294783_Chip-Seq_NPCs_Mouse0.86657823
170SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85606585
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.85247356
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85056209
173ARNT_22903824_ChIP-Seq_MCF-7_Human0.84499390
174CTCF_27219007_Chip-Seq_Bcells_Human0.83501480
175TP53_20018659_ChIP-ChIP_R1E_Mouse0.83053511
176RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82240234
177BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81962064
178OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81741850
179SMAD4_21741376_ChIP-Seq_HESCs_Human0.80897971
180SMAD3_21741376_ChIP-Seq_EPCs_Human0.80789240
181SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79477071
182SMAD_19615063_ChIP-ChIP_OVARY_Human0.77998261
183RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77701099
184YAP1_20516196_ChIP-Seq_MESCs_Mouse0.75861102
185STAT3_23295773_ChIP-Seq_U87_Human0.74841632
186TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.73035222
187KLF4_19829295_ChIP-Seq_ESCs_Human0.72827836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77376541
2MP0003880_abnormal_central_pattern4.48456921
3MP0003635_abnormal_synaptic_transmissio3.79925463
4MP0004270_analgesia3.35276190
5MP0003436_decreased_susceptibility_to3.34221817
6MP0003724_increased_susceptibility_to3.32170137
7MP0006082_CNS_inflammation3.20043962
8MP0002064_seizures3.19382156
9MP0002063_abnormal_learning/memory/cond3.10631865
10MP0001968_abnormal_touch/_nociception3.09070470
11MP0009046_muscle_twitch3.05030471
12MP0009745_abnormal_behavioral_response3.01174254
13MP0003191_abnormal_cellular_cholesterol3.00778816
14MP0003329_amyloid_beta_deposits2.78847645
15MP0009785_altered_susceptibility_to2.61795722
16MP0002148_abnormal_hypersensitivity_rea2.61682201
17MP0002419_abnormal_innate_immunity2.61203074
18MP0004858_abnormal_nervous_system2.56352247
19MP0002735_abnormal_chemical_nociception2.53805082
20MP0002572_abnormal_emotion/affect_behav2.52573535
21MP0002734_abnormal_mechanical_nocicepti2.51287091
22MP0002736_abnormal_nociception_after2.49557562
23MP0002733_abnormal_thermal_nociception2.45679494
24MP0008260_abnormal_autophagy2.43355559
25MP0001835_abnormal_antigen_presentation2.42484628
26MP0005025_abnormal_response_to2.34005756
27MP0002909_abnormal_adrenal_gland2.26995119
28MP0001501_abnormal_sleep_pattern2.26244553
29MP0001440_abnormal_grooming_behavior2.25505985
30MP0005000_abnormal_immune_tolerance2.22717636
31MP0005671_abnormal_response_to2.22627528
32MP0001790_abnormal_immune_system2.20937355
33MP0005387_immune_system_phenotype2.20937355
34MP0001970_abnormal_pain_threshold2.18943400
35MP0002272_abnormal_nervous_system2.12391092
36MP0006276_abnormal_autonomic_nervous2.11058302
37MP0003172_abnormal_lysosome_physiology2.01558568
38MP0003806_abnormal_nucleotide_metabolis1.99932291
39MP0000343_altered_response_to1.97151830
40MP0001533_abnormal_skeleton_physiology1.97125187
41MP0009780_abnormal_chondrocyte_physiolo1.95958571
42MP0000604_amyloidosis1.91914509
43MP0002452_abnormal_antigen_presenting1.87448101
44MP0010386_abnormal_urinary_bladder1.87387306
45MP0002723_abnormal_immune_serum1.86887991
46MP0005464_abnormal_platelet_physiology1.84328504
47MP0005423_abnormal_somatic_nervous1.81921542
48MP0000685_abnormal_immune_system1.81502066
49MP0003300_gastrointestinal_ulcer1.81440167
50MP0005451_abnormal_body_composition1.79198467
51MP0001486_abnormal_startle_reflex1.78877928
52MP0002067_abnormal_sensory_capabilities1.78687476
53MP0005058_abnormal_lysosome_morphology1.78232148
54MP0002822_catalepsy1.76126904
55MP0001800_abnormal_humoral_immune1.74985529
56MP0004811_abnormal_neuron_physiology1.71427022
57MP0002420_abnormal_adaptive_immunity1.69610912
58MP0001819_abnormal_immune_cell1.68565975
59MP0002184_abnormal_innervation1.66982269
60MP0009764_decreased_sensitivity_to1.63138119
61MP0001845_abnormal_inflammatory_respons1.59672830
62MP0004924_abnormal_behavior1.49607810
63MP0005386_behavior/neurological_phenoty1.49607810
64MP0003633_abnormal_nervous_system1.48185485
65MP0000778_abnormal_nervous_system1.46928678
66MP0002139_abnormal_hepatobiliary_system1.46065851
67MP0008469_abnormal_protein_level1.45714669
68MP0003879_abnormal_hair_cell1.44936918
69MP0000955_abnormal_spinal_cord1.41978502
70MP0008569_lethality_at_weaning1.41458580
71MP0010155_abnormal_intestine_physiology1.41170134
72MP0002557_abnormal_social/conspecific_i1.39666069
73MP0003303_peritoneal_inflammation1.39244189
74MP0004947_skin_inflammation1.39074767
75MP0000013_abnormal_adipose_tissue1.38521590
76MP0002066_abnormal_motor_capabilities/c1.33234168
77MP0003075_altered_response_to1.32537310
78MP0001502_abnormal_circadian_rhythm1.27025916
79MP0002998_abnormal_bone_remodeling1.26590726
80MP0002090_abnormal_vision1.26134720
81MP0004510_myositis1.25141961
82MP0001984_abnormal_olfaction1.24242997
83MP0002405_respiratory_system_inflammati1.23800092
84MP0005645_abnormal_hypothalamus_physiol1.23500124
85MP0002882_abnormal_neuron_morphology1.22259671
86MP0002837_dystrophic_cardiac_calcinosis1.21812796
87MP0003634_abnormal_glial_cell1.20094842
88MP0009278_abnormal_bone_marrow1.20064332
89MP0000465_gastrointestinal_hemorrhage1.19215069
90MP0003122_maternal_imprinting1.18533045
91MP0000858_altered_metastatic_potential1.18488637
92MP0005535_abnormal_body_temperature1.17377243
93MP0003631_nervous_system_phenotype1.16402747
94MP0010234_abnormal_vibrissa_follicle1.13932096
95MP0008961_abnormal_basal_metabolism1.13530025
96MP0009333_abnormal_splenocyte_physiolog1.12594023
97MP0008004_abnormal_stomach_pH1.12304691
98MP0001905_abnormal_dopamine_level1.10960332
99MP0004142_abnormal_muscle_tone1.10579460
100MP0001529_abnormal_vocalization1.10203763
101MP0000716_abnormal_immune_system1.10164340
102MP0005167_abnormal_blood-brain_barrier1.08848402
103MP0003866_abnormal_defecation1.07941456
104MP0003283_abnormal_digestive_organ1.04874652
105MP0001853_heart_inflammation1.04108123
106MP0003183_abnormal_peptide_metabolism1.02024347
107MP0003690_abnormal_glial_cell1.01077044
108MP0000015_abnormal_ear_pigmentation1.00284302
109MP0003828_pulmonary_edema0.96512016
110MP0002229_neurodegeneration0.95711043
111MP0002069_abnormal_eating/drinking_beha0.95654409
112MP0006054_spinal_hemorrhage0.95589241
113MP0005165_increased_susceptibility_to0.94679027
114MP0008874_decreased_physiological_sensi0.93808469
115MP0005365_abnormal_bile_salt0.92532509
116MP0003448_altered_tumor_morphology0.92248841
117MP0005584_abnormal_enzyme/coenzyme_acti0.90276569
118MP0000569_abnormal_digit_pigmentation0.90088103
119MP0001542_abnormal_bone_strength0.88927071
120MP0002876_abnormal_thyroid_physiology0.87863734
121MP0004885_abnormal_endolymph0.87844859
122MP0002277_abnormal_respiratory_mucosa0.86859533
123MP0005646_abnormal_pituitary_gland0.84602288
124MP0002152_abnormal_brain_morphology0.84003942
125MP0005166_decreased_susceptibility_to0.83123666
126MP0002398_abnormal_bone_marrow0.83078791
127MP0000920_abnormal_myelination0.82383455
128MP0002429_abnormal_blood_cell0.80800663
129MP0005397_hematopoietic_system_phenotyp0.80613807
130MP0001545_abnormal_hematopoietic_system0.80613807
131MP0000689_abnormal_spleen_morphology0.80368867
132MP0003656_abnormal_erythrocyte_physiolo0.79016847
133MP0002332_abnormal_exercise_endurance0.76940101
134MP0001851_eye_inflammation0.76917399
135MP0005390_skeleton_phenotype0.76376721
136MP0003632_abnormal_nervous_system0.76316252
137MP0005319_abnormal_enzyme/_coenzyme0.75425619
138MP0003453_abnormal_keratinocyte_physiol0.74495260
139MP0002638_abnormal_pupillary_reflex0.72825351
140MP0002132_abnormal_respiratory_system0.72391097
141MP0009763_increased_sensitivity_to0.70762515
142MP0002722_abnormal_immune_system0.68839113
143MP0004043_abnormal_pH_regulation0.68326590
144MP0008872_abnormal_physiological_respon0.67662406
145MP0004130_abnormal_muscle_cell0.67459780
146MP0003795_abnormal_bone_structure0.67350346
147MP0004742_abnormal_vestibular_system0.66448507
148MP0005448_abnormal_energy_balance0.64222618
149MP0001663_abnormal_digestive_system0.63796565
150MP0000249_abnormal_blood_vessel0.63405242
151MP0001348_abnormal_lacrimal_gland0.62634002
152MP0004883_abnormal_blood_vessel0.60864324
153MP0005623_abnormal_meninges_morphology0.60411291
154MP0002118_abnormal_lipid_homeostasis0.60308609
155MP0009840_abnormal_foam_cell0.58084858
156MP0001765_abnormal_ion_homeostasis0.57294592
157MP0005310_abnormal_salivary_gland0.56941631
158MP0000538_abnormal_urinary_bladder0.56680242
159MP0005551_abnormal_eye_electrophysiolog0.55506500
160MP0002078_abnormal_glucose_homeostasis0.54267087
161MP0002693_abnormal_pancreas_physiology0.54265572
162MP0001177_atelectasis0.53728633
163MP0010329_abnormal_lipoprotein_level0.53488576
164MP0003195_calcinosis0.51503687
165MP0005164_abnormal_response_to0.49341279
166MP0001664_abnormal_digestion0.48723876
167MP0002877_abnormal_melanocyte_morpholog0.48283763
168MP0003638_abnormal_response/metabolism_0.48055001
169MP0003953_abnormal_hormone_level0.48005907
170MP0000681_abnormal_thyroid_gland0.47670700

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.09077728
2Myokymia (HP:0002411)5.28269323
3Visual hallucinations (HP:0002367)5.20718532
4Abnormality of macrophages (HP:0004311)5.06051348
5Focal seizures (HP:0007359)4.89940964
6Supranuclear gaze palsy (HP:0000605)4.71227683
7Eczematoid dermatitis (HP:0000976)4.53398646
8Recurrent abscess formation (HP:0002722)4.44897424
9Vacuolated lymphocytes (HP:0001922)4.39783468
10Recurrent bacterial skin infections (HP:0005406)4.27858695
11Loss of speech (HP:0002371)4.01305870
12Epileptic encephalopathy (HP:0200134)3.97517734
13Absence seizures (HP:0002121)3.91933263
14Atonic seizures (HP:0010819)3.90531775
15Neurofibrillary tangles (HP:0002185)3.79775778
16Generalized tonic-clonic seizures (HP:0002069)3.69873623
17Cerebral inclusion bodies (HP:0100314)3.69649041
18Dialeptic seizures (HP:0011146)3.66393695
19Disinhibition (HP:0000734)3.44939663
20Increased cerebral lipofuscin (HP:0011813)3.44128107
21Systemic lupus erythematosus (HP:0002725)3.41977062
22Polyphagia (HP:0002591)3.31423413
23Progressive cerebellar ataxia (HP:0002073)3.31353011
24Mutism (HP:0002300)3.30234159
25Recurrent gram-negative bacterial infections (HP:0005420)3.29238964
26Abnormal eating behavior (HP:0100738)3.24857164
27Myositis (HP:0100614)3.23163863
28Febrile seizures (HP:0002373)3.15472620
29Amyloidosis (HP:0011034)3.11650615
30Action tremor (HP:0002345)3.09356502
31Stomatitis (HP:0010280)3.06974012
32Orchitis (HP:0100796)3.04961906
33Petechiae (HP:0000967)2.99190968
34Obstructive lung disease (HP:0006536)2.95201937
35Chronic obstructive pulmonary disease (HP:0006510)2.95201937
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.93612868
37Progressive neurologic deterioration (HP:0002344)2.85319417
38Dysostosis multiplex (HP:0000943)2.82198243
39Pheochromocytoma (HP:0002666)2.80793819
40Amblyopia (HP:0000646)2.80207543
41Depression (HP:0000716)2.77256281
42Failure to thrive in infancy (HP:0001531)2.76553327
43Purpura (HP:0000979)2.76487133
44Diplopia (HP:0000651)2.76437059
45Abnormality of binocular vision (HP:0011514)2.76437059
46Mediastinal lymphadenopathy (HP:0100721)2.75155185
47Agitation (HP:0000713)2.71443778
48Elevated erythrocyte sedimentation rate (HP:0003565)2.67784353
49Retrobulbar optic neuritis (HP:0100654)2.64297063
50Optic neuritis (HP:0100653)2.64297063
51Ankle clonus (HP:0011448)2.61856510
52Anxiety (HP:0000739)2.58878365
53Progressive inability to walk (HP:0002505)2.57980433
54Abnormality of liposaccharide metabolism (HP:0010968)2.57385756
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.57385756
56Abnormality of glycolipid metabolism (HP:0010969)2.57385756
57Neuronal loss in central nervous system (HP:0002529)2.54875656
58Recurrent skin infections (HP:0001581)2.54714001
59Epileptiform EEG discharges (HP:0011182)2.50993052
60Abnormal social behavior (HP:0012433)2.50196358
61Impaired social interactions (HP:0000735)2.50196358
62Urinary glycosaminoglycan excretion (HP:0003541)2.47936583
63Mucopolysacchariduria (HP:0008155)2.47936583
64Apathy (HP:0000741)2.47757458
65Poor eye contact (HP:0000817)2.47685957
66Neuroendocrine neoplasm (HP:0100634)2.47586179
67Hypercortisolism (HP:0001578)2.47506588
68Truncal ataxia (HP:0002078)2.45335099
69Papilledema (HP:0001085)2.44633052
70Urticaria (HP:0001025)2.44046114
71Torticollis (HP:0000473)2.43873590
72EEG with generalized epileptiform discharges (HP:0011198)2.43018591
73Hepatosplenomegaly (HP:0001433)2.42682894
74Status epilepticus (HP:0002133)2.42164413
75Hyperventilation (HP:0002883)2.42026159
76Abnormality of polysaccharide metabolism (HP:0011012)2.38772917
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38772917
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38772917
79Episodic fever (HP:0001954)2.38722281
80Diminished motivation (HP:0000745)2.37487702
81Global brain atrophy (HP:0002283)2.36928779
82Hypsarrhythmia (HP:0002521)2.35398752
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35044013
84Increased serum ferritin (HP:0003281)2.34924288
85Postural instability (HP:0002172)2.34197246
86Limb dystonia (HP:0002451)2.31017456
87Hemiparesis (HP:0001269)2.30552979
88Focal dystonia (HP:0004373)2.29014927
89Dysdiadochokinesis (HP:0002075)2.28420462
90Gingivitis (HP:0000230)2.26612675
91Akinesia (HP:0002304)2.25377546
92Termporal pattern (HP:0011008)2.24902927
93Insidious onset (HP:0003587)2.24902927
94Dysmetria (HP:0001310)2.24161492
95Generalized myoclonic seizures (HP:0002123)2.23647066
96Prolonged neonatal jaundice (HP:0006579)2.23454282
97Psychosis (HP:0000709)2.21059545
98Recurrent fungal infections (HP:0002841)2.18647190
99Impaired vibration sensation in the lower limbs (HP:0002166)2.18081503
100Vertebral compression fractures (HP:0002953)2.17726558
101Genetic anticipation (HP:0003743)2.17578370
102Excessive salivation (HP:0003781)2.17270444
103Drooling (HP:0002307)2.17270444
104Amyotrophic lateral sclerosis (HP:0007354)2.16642627
105Craniofacial dystonia (HP:0012179)2.16053199
106Upper motor neuron abnormality (HP:0002127)2.14624611
107Rapidly progressive (HP:0003678)2.13913842
108Meningitis (HP:0001287)2.13677606
109Postural tremor (HP:0002174)2.13002857
110Hypoventilation (HP:0002791)2.12475769
111Interstitial pulmonary disease (HP:0006530)2.11979215
112Agnosia (HP:0010524)2.11896441
113Bradykinesia (HP:0002067)2.11819227
114Urinary bladder sphincter dysfunction (HP:0002839)2.11765359
115Nuclear cataract (HP:0100018)2.10860454
116Malnutrition (HP:0004395)2.10276571
117Broad-based gait (HP:0002136)2.06300069
118Increased IgE level (HP:0003212)2.06168557
119Pulmonary infiltrates (HP:0002113)2.06106870
120Hypokinesia (HP:0002375)2.05585637
121Spontaneous hematomas (HP:0007420)2.04862834
122Gingival bleeding (HP:0000225)2.03109960
123Clumsiness (HP:0002312)2.03019638
124Dementia (HP:0000726)2.02934532
125Intention tremor (HP:0002080)2.02698926
126Rigidity (HP:0002063)1.99926037
127Personality changes (HP:0000751)1.98206222
128Abnormality of the lower motor neuron (HP:0002366)1.97031984
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94893885
130Autoimmune thrombocytopenia (HP:0001973)1.94201973
131Abnormality of iron homeostasis (HP:0011031)1.92808047
132Urinary urgency (HP:0000012)1.92607381
133Axonal loss (HP:0003447)1.91885060
134Oligomenorrhea (HP:0000876)1.90647097
135Stereotypic behavior (HP:0000733)1.89691899
136Cellulitis (HP:0100658)1.89283290
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88936188
138Increased IgM level (HP:0003496)1.88649489
139Vasculitis (HP:0002633)1.88040016
140Delusions (HP:0000746)1.87903442
141Pathologic fracture (HP:0002756)1.87812294
142Spastic gait (HP:0002064)1.87215934
143Restlessness (HP:0000711)1.86805112
144Glomerulonephritis (HP:0000099)1.86510719
145Hemoptysis (HP:0002105)1.83853040
146Gastrointestinal infarctions (HP:0005244)1.82666627
147Myocardial infarction (HP:0001658)1.81788216
148Hand muscle atrophy (HP:0009130)1.81466134
149Hypergammaglobulinemia (HP:0010702)1.80772691
150Retinal atrophy (HP:0001105)1.80650491
151Impaired smooth pursuit (HP:0007772)1.78663154
152Abnormality of the corticospinal tract (HP:0002492)1.78275171
153Absent speech (HP:0001344)1.78067449
154Inappropriate behavior (HP:0000719)1.78018807
155Memory impairment (HP:0002354)1.75874826
156Epistaxis (HP:0000421)1.73683411
157Basal ganglia calcification (HP:0002135)1.73121914
158Polyneuropathy (HP:0001271)1.72969496
159Increased CSF protein (HP:0002922)1.72772382
160Chest pain (HP:0100749)1.72364213
161Cardiomegaly (HP:0001640)1.71699397
162Abnormality of the nasal mucosa (HP:0000433)1.71129192
163Keratoconjunctivitis sicca (HP:0001097)1.70306250
164Abnormal gallbladder physiology (HP:0012438)1.68335227
165Cholecystitis (HP:0001082)1.68335227
166Asymmetric septal hypertrophy (HP:0001670)1.67644979
167Encephalitis (HP:0002383)1.65596269
168Abnormality of the motor neurons (HP:0002450)1.64669322
169Abnormal neuron morphology (HP:0012757)1.64669322
170Pustule (HP:0200039)1.64079868
171Chronic mucocutaneous candidiasis (HP:0002728)1.62003777
172Recurrent cutaneous fungal infections (HP:0011370)1.62003777
173Osteomyelitis (HP:0002754)1.57767311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.37790048
2NTRK33.68676237
3RIPK43.34787237
4EPHA43.07724208
5MAP3K123.05895557
6MARK12.94897905
7TESK22.87375704
8KSR22.86367706
9MAP3K42.64710388
10MINK12.59254707
11BLK2.54516846
12DAPK22.51808152
13NTRK12.32816726
14MAP3K32.24599870
15ARAF2.23034930
16TYK22.13719869
17PAK62.12285358
18MAP2K32.08076626
19MAP2K42.06597699
20MAP2K72.03449231
21IRAK32.02572191
22IRAK42.00150990
23TBK11.92477824
24CSK1.76416874
25MAP3K21.74588234
26MAP4K11.73314686
27CAMKK11.71658930
28TAOK21.71601500
29NTRK21.69589267
30EPHB11.68388732
31KSR11.68056343
32GRK51.66447391
33DAPK11.63015556
34ZAP701.54736058
35PLK21.50840639
36GRK61.40739156
37CDK191.39518142
38CDK51.39256964
39PRKD31.39153274
40TNK21.39084941
41TGFBR21.28964040
42SCYL21.26937426
43PNCK1.26563916
44CAMKK21.25762528
45GRK71.17174945
46PIM21.16377098
47RET1.13373345
48LATS21.13222666
49MAP3K11.10393882
50PRKD21.09834333
51FES1.08965902
52IKBKE1.08067476
53CASK1.07057002
54TRIB31.06623829
55PRKCG1.05528594
56MAP3K131.05232265
57SIK21.04408997
58NME21.03802402
59MAP3K141.03278888
60PDK21.02235538
61IKBKB0.98694933
62UHMK10.96587257
63HCK0.94927045
64LYN0.93234286
65CDK140.92764064
66TYRO30.91967343
67JAK20.90728609
68MAP3K110.88112959
69FGR0.87729707
70JAK30.87681119
71PAK40.86097548
72CDK180.85008219
73TAOK10.83947878
74CSF1R0.82634431
75CAMK2A0.82239285
76CDK150.81466345
77PRKG20.80444638
78PAK30.80096378
79IRAK20.79879129
80MAP2K60.78413688
81MAPK120.77134151
82BCKDK0.76722863
83BMPR20.75781626
84DAPK30.75093372
85MAP2K10.74530006
86ERN10.74219791
87PDPK10.74066630
88STK380.73255859
89RAF10.72234933
90CDK11A0.71945676
91PTK2B0.71753197
92CSNK1G20.71655923
93FER0.70163910
94JAK10.69840449
95PRKCH0.68020438
96CSNK1G30.67006266
97MARK20.66902912
98LCK0.66376988
99PRKCZ0.65926073
100CDC42BPA0.65386507
101SIK30.64504035
102BTK0.64387701
103EPHA30.64248350
104RIPK10.63844892
105ABL20.63655528
106MAPKAPK30.63471226
107BMX0.62426937
108SGK4940.61669919
109SGK2230.61669919
110MARK30.61273073
111DDR20.60886322
112PHKG20.59765991
113PHKG10.59765991
114TXK0.59731494
115PRKCE0.59471161
116BRAF0.59395521
117CAMK2B0.59351140
118WNK30.59151151
119PDK10.58474395
120MAPK130.56507635
121LIMK10.56427430
122ALK0.53904154
123KDR0.49336630
124FYN0.48855272
125PTK20.48317702
126MAP3K60.47941707
127RPS6KA20.47749582
128STK110.46197087
129SGK30.44836041
130PRKD10.44177527
131PRKCD0.43286034
132CSNK1A1L0.43284743
133OXSR10.41529321
134PTK60.41421951
135PRPF4B0.40794070
136MST1R0.40645240
137MAP3K50.40363835
138IRAK10.40229068
139SIK10.39856057
140DYRK1A0.39742419
141NME10.39206290
142MOS0.39206029
143CAMK2G0.38990441
144SGK10.38676942
145SYK0.38582392
146CAMK10.37544302
147MAPKAPK20.37044803
148CAMK1G0.34951105
149MATK0.33637853
150CAMK2D0.33326711
151PINK10.33151998
152TESK10.31775239
153LMTK20.31545072

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047213.99573249
2Other glycan degradation_Homo sapiens_hsa005113.46039554
3* Collecting duct acid secretion_Homo sapiens_hsa049662.82587294
4Nicotine addiction_Homo sapiens_hsa050332.78460063
5Staphylococcus aureus infection_Homo sapiens_hsa051502.53742486
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48273587
7Osteoclast differentiation_Homo sapiens_hsa043802.41092200
8GABAergic synapse_Homo sapiens_hsa047272.30235562
9Long-term potentiation_Homo sapiens_hsa047202.17205143
10Leishmaniasis_Homo sapiens_hsa051402.12847342
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10616610
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.07675621
13Circadian entrainment_Homo sapiens_hsa047132.02637183
14* Vibrio cholerae infection_Homo sapiens_hsa051102.01204331
15Amphetamine addiction_Homo sapiens_hsa050311.94085134
16Olfactory transduction_Homo sapiens_hsa047401.91103718
17Dopaminergic synapse_Homo sapiens_hsa047281.89814111
18Morphine addiction_Homo sapiens_hsa050321.87538353
19Glutamatergic synapse_Homo sapiens_hsa047241.87272140
20Allograft rejection_Homo sapiens_hsa053301.85996879
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83656691
22Graft-versus-host disease_Homo sapiens_hsa053321.76427569
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76205333
24Insulin secretion_Homo sapiens_hsa049111.71437937
25Autoimmune thyroid disease_Homo sapiens_hsa053201.67855385
26Salivary secretion_Homo sapiens_hsa049701.64431211
27Cholinergic synapse_Homo sapiens_hsa047251.56216938
28Long-term depression_Homo sapiens_hsa047301.53833324
29Asthma_Homo sapiens_hsa053101.50140933
30Cocaine addiction_Homo sapiens_hsa050301.50127242
31Pertussis_Homo sapiens_hsa051331.48140857
32Legionellosis_Homo sapiens_hsa051341.47062906
33Antigen processing and presentation_Homo sapiens_hsa046121.43189591
34Serotonergic synapse_Homo sapiens_hsa047261.41612237
35* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40272198
36Gastric acid secretion_Homo sapiens_hsa049711.39564506
37* Lysosome_Homo sapiens_hsa041421.34081308
38Malaria_Homo sapiens_hsa051441.33413531
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33021537
40Renin secretion_Homo sapiens_hsa049241.32339053
41Taste transduction_Homo sapiens_hsa047421.31863658
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30836063
43Sulfur metabolism_Homo sapiens_hsa009201.25793041
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25321751
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23262334
46GnRH signaling pathway_Homo sapiens_hsa049121.19738608
47Shigellosis_Homo sapiens_hsa051311.19524211
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19324149
49Oxytocin signaling pathway_Homo sapiens_hsa049211.18749349
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17693993
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.17260014
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17258169
53Gap junction_Homo sapiens_hsa045401.16783358
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15738047
55Viral myocarditis_Homo sapiens_hsa054161.15234842
56* Phagosome_Homo sapiens_hsa041451.13685139
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13044795
58Toxoplasmosis_Homo sapiens_hsa051451.12649839
59Type II diabetes mellitus_Homo sapiens_hsa049301.12161229
60B cell receptor signaling pathway_Homo sapiens_hsa046621.11535438
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10267786
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09231236
63Nitrogen metabolism_Homo sapiens_hsa009101.09196274
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08638217
65Glioma_Homo sapiens_hsa052141.06340960
66Estrogen signaling pathway_Homo sapiens_hsa049151.05864273
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05790076
68* Rheumatoid arthritis_Homo sapiens_hsa053231.04624578
69Hematopoietic cell lineage_Homo sapiens_hsa046401.03212327
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.99344576
71TNF signaling pathway_Homo sapiens_hsa046680.97481986
72Sphingolipid metabolism_Homo sapiens_hsa006000.95086482
73Influenza A_Homo sapiens_hsa051640.94995434
74Calcium signaling pathway_Homo sapiens_hsa040200.94817329
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91162774
76Galactose metabolism_Homo sapiens_hsa000520.90205523
77* Oxidative phosphorylation_Homo sapiens_hsa001900.89625603
78Prion diseases_Homo sapiens_hsa050200.88238366
79Type I diabetes mellitus_Homo sapiens_hsa049400.85952662
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85437621
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84223579
82Melanogenesis_Homo sapiens_hsa049160.81880502
83VEGF signaling pathway_Homo sapiens_hsa043700.81017234
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.80759777
85Fructose and mannose metabolism_Homo sapiens_hsa000510.79454956
86cAMP signaling pathway_Homo sapiens_hsa040240.78471793
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.77828164
88ErbB signaling pathway_Homo sapiens_hsa040120.77638427
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75652656
90Dorso-ventral axis formation_Homo sapiens_hsa043200.73895519
91Endocytosis_Homo sapiens_hsa041440.73681568
92Alzheimers disease_Homo sapiens_hsa050100.72327958
93Hepatitis C_Homo sapiens_hsa051600.71667827
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.70451128
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68403793
96mTOR signaling pathway_Homo sapiens_hsa041500.66857442
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.66812562
98Primary immunodeficiency_Homo sapiens_hsa053400.66804974
99Pancreatic secretion_Homo sapiens_hsa049720.66104373
100Axon guidance_Homo sapiens_hsa043600.65243278
101* Tuberculosis_Homo sapiens_hsa051520.65242738
102Apoptosis_Homo sapiens_hsa042100.62870882
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62138896
104Thyroid hormone synthesis_Homo sapiens_hsa049180.61390404
105Cardiac muscle contraction_Homo sapiens_hsa042600.60201256
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.58744777
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58455544
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57021930
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56790554
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56191881
111Acute myeloid leukemia_Homo sapiens_hsa052210.56035678
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55883672
113Choline metabolism in cancer_Homo sapiens_hsa052310.55137629
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54693834
115Measles_Homo sapiens_hsa051620.54693360
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54437417
117T cell receptor signaling pathway_Homo sapiens_hsa046600.53704566
118PPAR signaling pathway_Homo sapiens_hsa033200.52655055
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52330782
120MAPK signaling pathway_Homo sapiens_hsa040100.51853783
121Renal cell carcinoma_Homo sapiens_hsa052110.51511322
122Salmonella infection_Homo sapiens_hsa051320.51368507
123Fatty acid elongation_Homo sapiens_hsa000620.51197551
124Pentose phosphate pathway_Homo sapiens_hsa000300.50545915
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.49424367
126Parkinsons disease_Homo sapiens_hsa050120.48121681
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46231183
128Phototransduction_Homo sapiens_hsa047440.45308395
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45184595
130Platelet activation_Homo sapiens_hsa046110.44466112
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.44279437
132African trypanosomiasis_Homo sapiens_hsa051430.43138047
133Arginine biosynthesis_Homo sapiens_hsa002200.43043222
134Oocyte meiosis_Homo sapiens_hsa041140.42983768
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.42626467
136Hepatitis B_Homo sapiens_hsa051610.42493185
137Insulin signaling pathway_Homo sapiens_hsa049100.41595953
138Herpes simplex infection_Homo sapiens_hsa051680.41221174
139Regulation of autophagy_Homo sapiens_hsa041400.39001160
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38430272
141Glucagon signaling pathway_Homo sapiens_hsa049220.38271933
142Ras signaling pathway_Homo sapiens_hsa040140.37992755
143Bile secretion_Homo sapiens_hsa049760.37772950
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37650319
145Chemokine signaling pathway_Homo sapiens_hsa040620.37046261
146Glutathione metabolism_Homo sapiens_hsa004800.34402546
147Rap1 signaling pathway_Homo sapiens_hsa040150.33961535
148Complement and coagulation cascades_Homo sapiens_hsa046100.33638858
149Non-small cell lung cancer_Homo sapiens_hsa052230.33395732
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33171475
151Amoebiasis_Homo sapiens_hsa051460.31988604
152Mineral absorption_Homo sapiens_hsa049780.31230116
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31004134
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.30288475
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29921541
156Bladder cancer_Homo sapiens_hsa052190.24462776
157HIF-1 signaling pathway_Homo sapiens_hsa040660.22885551
158Arachidonic acid metabolism_Homo sapiens_hsa005900.22489977
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.22086533

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