ATP6V0E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.61074787
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.60004920
3vocalization behavior (GO:0071625)5.24734146
4neuron cell-cell adhesion (GO:0007158)5.16862272
5glutamate secretion (GO:0014047)5.13097466
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.08617615
7regulation of synaptic vesicle exocytosis (GO:2000300)5.04558424
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.03499391
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97391072
10protein localization to synapse (GO:0035418)4.83487739
11synaptic vesicle maturation (GO:0016188)4.83157851
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.70533371
13neuronal action potential propagation (GO:0019227)4.69311037
14regulation of glutamate receptor signaling pathway (GO:1900449)4.64349408
15sodium ion export (GO:0071436)4.57866587
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56807928
17neurotransmitter-gated ion channel clustering (GO:0072578)4.53362996
18regulation of synaptic vesicle transport (GO:1902803)4.46528598
19locomotory exploration behavior (GO:0035641)4.44058708
20neurotransmitter secretion (GO:0007269)4.36721285
21presynaptic membrane assembly (GO:0097105)4.27314134
22neuronal ion channel clustering (GO:0045161)4.22975437
23neuron-neuron synaptic transmission (GO:0007270)4.21884037
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.20758510
25synaptic transmission, glutamatergic (GO:0035249)4.17292848
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14814922
27dendritic spine morphogenesis (GO:0060997)4.05899404
28presynaptic membrane organization (GO:0097090)4.04945344
29establishment of mitochondrion localization (GO:0051654)3.94540120
30postsynaptic membrane organization (GO:0001941)3.93981841
31glutamate receptor signaling pathway (GO:0007215)3.91779186
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.84983871
33pyrimidine nucleobase catabolic process (GO:0006208)3.83555031
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78330065
35positive regulation of synapse maturation (GO:0090129)3.76723272
36exploration behavior (GO:0035640)3.75082182
37long-term synaptic potentiation (GO:0060291)3.75010809
38regulation of neuronal synaptic plasticity (GO:0048168)3.73269717
39amino acid import (GO:0043090)3.72825339
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71576267
41L-amino acid import (GO:0043092)3.68808231
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65849425
43gamma-aminobutyric acid transport (GO:0015812)3.63175131
44neurotransmitter transport (GO:0006836)3.60574658
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59725139
46positive regulation of dendritic spine development (GO:0060999)3.56304747
47positive regulation of membrane potential (GO:0045838)3.53568050
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53119514
49regulation of neurotransmitter secretion (GO:0046928)3.52752364
50dendritic spine organization (GO:0097061)3.51375511
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.48954115
52potassium ion homeostasis (GO:0055075)3.47935712
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.47698543
54regulation of postsynaptic membrane potential (GO:0060078)3.46520418
55startle response (GO:0001964)3.46254705
56long-term memory (GO:0007616)3.42457062
57regulation of synapse structural plasticity (GO:0051823)3.41720327
58regulation of dendritic spine morphogenesis (GO:0061001)3.39799949
59neuron recognition (GO:0008038)3.39335220
60proline transport (GO:0015824)3.37853551
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36811833
62cell migration in hindbrain (GO:0021535)3.34348965
63central nervous system myelination (GO:0022010)3.33816468
64axon ensheathment in central nervous system (GO:0032291)3.33816468
65synaptic vesicle endocytosis (GO:0048488)3.33626562
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.31747684
67cerebellar Purkinje cell layer development (GO:0021680)3.30747424
68regulation of neurotransmitter transport (GO:0051588)3.30152116
69cerebellar granule cell differentiation (GO:0021707)3.29792450
70regulation of synaptic plasticity (GO:0048167)3.29718531
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29372636
72acidic amino acid transport (GO:0015800)3.28796823
73potassium ion import (GO:0010107)3.27965034
74regulation of neurotransmitter levels (GO:0001505)3.27141228
75regulation of vesicle fusion (GO:0031338)3.27014747
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26139972
77regulation of synapse maturation (GO:0090128)3.24729550
78response to histamine (GO:0034776)3.24592713
79positive regulation of neurotransmitter transport (GO:0051590)3.23813488
80cell communication by electrical coupling (GO:0010644)3.23596180
81cellular sodium ion homeostasis (GO:0006883)3.23437601
82neuromuscular process controlling balance (GO:0050885)3.22588070
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22241615
84cerebellar Purkinje cell differentiation (GO:0021702)3.21907032
85nucleobase catabolic process (GO:0046113)3.17126752
86transmission of nerve impulse (GO:0019226)3.14687288
87* transferrin transport (GO:0033572)3.13493190
88* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.09701552
89* ATP hydrolysis coupled proton transport (GO:0015991)3.09701552
90positive regulation of synapse assembly (GO:0051965)3.08149399
91membrane hyperpolarization (GO:0060081)3.07791238
92positive regulation of synaptic transmission (GO:0050806)3.07772187
93synaptic transmission (GO:0007268)3.07337840
94synapse assembly (GO:0007416)3.06158477
95layer formation in cerebral cortex (GO:0021819)3.04867102
96positive regulation of neurotransmitter secretion (GO:0001956)3.04810289
97behavioral response to cocaine (GO:0048148)3.04791579
98negative regulation of dendrite morphogenesis (GO:0050774)3.04788564
99regulation of synaptic transmission, GABAergic (GO:0032228)3.03930292
100neuromuscular process controlling posture (GO:0050884)3.03681920
101cellular potassium ion homeostasis (GO:0030007)3.03531302
102establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03459326
103mitochondrion transport along microtubule (GO:0047497)3.03459326
104membrane depolarization (GO:0051899)3.03057864
105mechanosensory behavior (GO:0007638)3.01228065
106regulation of dendritic spine development (GO:0060998)2.99088955
107neurotransmitter uptake (GO:0001504)2.97407477
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97401361
109striatum development (GO:0021756)2.96652582
110neuromuscular synaptic transmission (GO:0007274)2.96538611
111dicarboxylic acid transport (GO:0006835)2.96403608
112regulation of synaptic transmission (GO:0050804)2.96004963
113learning (GO:0007612)2.95394571
114response to auditory stimulus (GO:0010996)2.95150988
115auditory behavior (GO:0031223)2.94476778
116membrane depolarization during action potential (GO:0086010)2.94128801
117synaptic vesicle transport (GO:0048489)2.92730798
118establishment of synaptic vesicle localization (GO:0097480)2.92730798
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92531392
120innervation (GO:0060384)2.91355576
121* ferric iron transport (GO:0015682)2.90746090
122* trivalent inorganic cation transport (GO:0072512)2.90746090
123activation of protein kinase A activity (GO:0034199)2.90355857
124axonal fasciculation (GO:0007413)2.90193526
125detection of calcium ion (GO:0005513)2.90182872
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88972311
127regulation of voltage-gated calcium channel activity (GO:1901385)2.87968705
128behavioral fear response (GO:0001662)2.87659859
129behavioral defense response (GO:0002209)2.87659859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46996100
2GBX2_23144817_ChIP-Seq_PC3_Human4.33424200
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13521151
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97140121
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89209759
6REST_21632747_ChIP-Seq_MESCs_Mouse2.74333330
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64999433
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53229065
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.51422867
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49853144
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48797096
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48797096
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45927456
14TAF15_26573619_Chip-Seq_HEK293_Human2.43474246
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41603699
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37421115
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31893306
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30307847
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29354875
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.28680952
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.27637901
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21233488
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.19804085
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18234633
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15109259
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.13291154
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12205175
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02978024
29DROSHA_22980978_ChIP-Seq_HELA_Human2.02959662
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02503307
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.00980641
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99299124
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87850384
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84994371
35AR_21572438_ChIP-Seq_LNCaP_Human1.84131601
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81331295
37SMAD4_21799915_ChIP-Seq_A2780_Human1.79601965
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76566491
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72934155
40P300_19829295_ChIP-Seq_ESCs_Human1.68798766
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68569826
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58701782
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.57182234
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54873737
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54819465
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53271131
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52139988
48IGF1R_20145208_ChIP-Seq_DFB_Human1.51579320
49VDR_22108803_ChIP-Seq_LS180_Human1.46145640
50RNF2_27304074_Chip-Seq_NSC_Mouse1.44155861
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41563705
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.41290420
53CTCF_27219007_Chip-Seq_Bcells_Human1.41027294
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40409455
55KDM2B_26808549_Chip-Seq_K562_Human1.40129008
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40114191
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39306765
58* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38724894
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38465092
60TET1_21490601_ChIP-Seq_MESCs_Mouse1.38085785
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37924124
62LXR_22292898_ChIP-Seq_THP-1_Human1.37548858
63AR_25329375_ChIP-Seq_VCAP_Human1.36062548
64FUS_26573619_Chip-Seq_HEK293_Human1.35342950
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.34823773
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33326105
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32963453
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.31173136
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28266159
70* STAT3_23295773_ChIP-Seq_U87_Human1.27157796
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23398103
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.22912291
73ZNF274_21170338_ChIP-Seq_K562_Hela1.21323447
74SMC4_20622854_ChIP-Seq_HELA_Human1.20839810
75ER_23166858_ChIP-Seq_MCF-7_Human1.20657560
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20171510
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19840384
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16869135
79TCF4_23295773_ChIP-Seq_U87_Human1.16652449
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.16367367
81P68_20966046_ChIP-Seq_HELA_Human1.15517483
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13981329
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13855259
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13632581
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12464436
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.09595511
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09533188
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.08115274
89RUNX2_22187159_ChIP-Seq_PCA_Human1.07655079
90AR_19668381_ChIP-Seq_PC3_Human1.06806406
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06354642
92OCT4_19829295_ChIP-Seq_ESCs_Human1.06006787
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05635763
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.04699976
95JUN_21703547_ChIP-Seq_K562_Human1.04606920
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03666877
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.02627545
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.01995692
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01439763
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01123514
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99636272
102ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98691981
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.97486773
104* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97054882
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.96972587
106NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.95907990
107SOX9_26525672_Chip-Seq_HEART_Mouse0.95233008
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93547381
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92357153
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91983963
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.91856634
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91020352
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.90951628
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90647598
115AHR_22903824_ChIP-Seq_MCF-7_Human0.90478440
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90141893
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90067204
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90067204
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89199475
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89050932
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87789989
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87185810
123* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86987257
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86963593
125P53_22387025_ChIP-Seq_ESCs_Mouse0.86407554
126CREB1_26743006_Chip-Seq_LNCaP_Human0.86301912
127* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86251759
128RING1B_27294783_Chip-Seq_NPCs_Mouse0.86050967
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84670890
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84342258
131NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84180632
132CTCF_20526341_ChIP-Seq_ESCs_Human0.81947608
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81878035
134THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79633485
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77985971
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76356823
137KLF4_19829295_ChIP-Seq_ESCs_Human0.75597988
138TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74463383
139YY1_21170310_ChIP-Seq_MESCs_Mouse0.73380202
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72613724
141SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.71679103
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.70844066
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70531761
144* MYC_19915707_ChIP-ChIP_AK7_Human0.70464080
145SA1_27219007_Chip-Seq_Bcells_Human0.69651386
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.69412562
147DPY_21335234_ChIP-Seq_ESCs_Mouse0.69279106
148SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67073103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.14437086
2MP0003880_abnormal_central_pattern4.99096563
3MP0003635_abnormal_synaptic_transmissio3.76637264
4MP0004270_analgesia3.38957842
5MP0009745_abnormal_behavioral_response3.28639839
6MP0009046_muscle_twitch3.24725450
7MP0001968_abnormal_touch/_nociception3.18206484
8MP0002064_seizures3.13100821
9MP0002063_abnormal_learning/memory/cond3.06198970
10MP0002736_abnormal_nociception_after2.79682090
11MP0002734_abnormal_mechanical_nocicepti2.76304374
12MP0002572_abnormal_emotion/affect_behav2.75009058
13MP0002272_abnormal_nervous_system2.73233743
14MP0002735_abnormal_chemical_nociception2.48393763
15MP0002822_catalepsy2.48219770
16MP0001486_abnormal_startle_reflex2.44857422
17MP0005423_abnormal_somatic_nervous2.43300911
18MP0001501_abnormal_sleep_pattern2.15328532
19MP0009780_abnormal_chondrocyte_physiolo2.10325946
20MP0002067_abnormal_sensory_capabilities2.10214018
21MP0001440_abnormal_grooming_behavior2.05492737
22MP0006276_abnormal_autonomic_nervous2.01323072
23MP0005646_abnormal_pituitary_gland1.99494854
24MP0001970_abnormal_pain_threshold1.98555315
25MP0002733_abnormal_thermal_nociception1.95619858
26MP0001529_abnormal_vocalization1.91937082
27MP0001984_abnormal_olfaction1.85543049
28MP0002184_abnormal_innervation1.84758040
29MP0003787_abnormal_imprinting1.81618772
30MP0002557_abnormal_social/conspecific_i1.73971146
31MP0000778_abnormal_nervous_system1.73932104
32MP0003879_abnormal_hair_cell1.70467152
33MP0001188_hyperpigmentation1.68406889
34MP0005386_behavior/neurological_phenoty1.68325933
35MP0004924_abnormal_behavior1.68325933
36MP0008569_lethality_at_weaning1.67978547
37MP0004142_abnormal_muscle_tone1.63719272
38MP0001905_abnormal_dopamine_level1.61380001
39MP0003122_maternal_imprinting1.58438029
40MP0004811_abnormal_neuron_physiology1.55378059
41MP0005645_abnormal_hypothalamus_physiol1.49786359
42MP0003690_abnormal_glial_cell1.48207392
43MP0000955_abnormal_spinal_cord1.47824036
44MP0003123_paternal_imprinting1.47501209
45MP0005551_abnormal_eye_electrophysiolog1.46553815
46MP0002882_abnormal_neuron_morphology1.44121868
47MP0002909_abnormal_adrenal_gland1.40268386
48MP0002066_abnormal_motor_capabilities/c1.37703786
49MP0003329_amyloid_beta_deposits1.37289348
50MP0010386_abnormal_urinary_bladder1.35608187
51MP0001502_abnormal_circadian_rhythm1.33195310
52MP0004858_abnormal_nervous_system1.32107806
53MP0004885_abnormal_endolymph1.22121854
54MP0002876_abnormal_thyroid_physiology1.21782209
55MP0000604_amyloidosis1.16233934
56MP0003183_abnormal_peptide_metabolism1.14836904
57MP0002229_neurodegeneration1.13248919
58MP0002837_dystrophic_cardiac_calcinosis1.10718789
59MP0003633_abnormal_nervous_system1.10646804
60MP0005171_absent_coat_pigmentation1.10386400
61MP0001986_abnormal_taste_sensitivity1.05501824
62MP0005499_abnormal_olfactory_system1.04994114
63MP0005394_taste/olfaction_phenotype1.04994114
64MP0004742_abnormal_vestibular_system1.04204967
65MP0002638_abnormal_pupillary_reflex1.01541931
66MP0002152_abnormal_brain_morphology1.00342835
67MP0001963_abnormal_hearing_physiology1.00286184
68MP0000013_abnormal_adipose_tissue1.00123850
69MP0003631_nervous_system_phenotype0.99574887
70MP0004043_abnormal_pH_regulation0.97866706
71MP0000751_myopathy0.97598919
72MP0005167_abnormal_blood-brain_barrier0.95354469
73MP0002752_abnormal_somatic_nervous0.94519625
74MP0002653_abnormal_ependyma_morphology0.90129091
75MP0000631_abnormal_neuroendocrine_gland0.89941144
76MP0002069_abnormal_eating/drinking_beha0.89842435
77MP0008872_abnormal_physiological_respon0.88753494
78MP0006072_abnormal_retinal_apoptosis0.87121777
79MP0003634_abnormal_glial_cell0.86966110
80MP0008877_abnormal_DNA_methylation0.86263934
81MP0004145_abnormal_muscle_electrophysio0.84256200
82MP0004085_abnormal_heartbeat0.78339164
83MP0001664_abnormal_digestion0.77057077
84MP0005253_abnormal_eye_physiology0.76656780
85MP0001177_atelectasis0.75300447
86MP0003632_abnormal_nervous_system0.71905566
87MP0004233_abnormal_muscle_weight0.71655494
88MP0001485_abnormal_pinna_reflex0.70432981
89MP0002751_abnormal_autonomic_nervous0.69451641
90MP0004215_abnormal_myocardial_fiber0.69421407
91MP0005535_abnormal_body_temperature0.69343703
92MP0000026_abnormal_inner_ear0.68711648
93MP0001346_abnormal_lacrimal_gland0.68251094
94MP0002090_abnormal_vision0.67073639
95MP0000681_abnormal_thyroid_gland0.66436172
96MP0005187_abnormal_penis_morphology0.66163635
97MP0003861_abnormal_nervous_system0.65877502
98MP0002249_abnormal_larynx_morphology0.65569921
99MP0000920_abnormal_myelination0.64801905
100MP0006292_abnormal_olfactory_placode0.62516514
101MP0008874_decreased_physiological_sensi0.60800461
102MP0001943_abnormal_respiration0.60304974
103MP0003137_abnormal_impulse_conducting0.60041521
104MP0003938_abnormal_ear_development0.57699594
105MP0003075_altered_response_to0.57530453
106MP0008789_abnormal_olfactory_epithelium0.56612167
107MP0005379_endocrine/exocrine_gland_phen0.55618856
108MP0010769_abnormal_survival0.55330180
109MP0003121_genomic_imprinting0.54929810
110MP0003956_abnormal_body_size0.53442146
111MP0002082_postnatal_lethality0.52840829
112MP0010770_preweaning_lethality0.52840829
113MP0005409_darkened_coat_color0.52751827
114MP0010768_mortality/aging0.52694657
115MP0004484_altered_response_of0.52562892
116MP0008260_abnormal_autophagy0.52529183
117MP0000639_abnormal_adrenal_gland0.52470262
118MP0003646_muscle_fatigue0.52229066
119MP0001348_abnormal_lacrimal_gland0.52074814
120MP0005623_abnormal_meninges_morphology0.50378103

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.39240466
2Myokymia (HP:0002411)5.55278827
3Atonic seizures (HP:0010819)5.25883796
4Epileptic encephalopathy (HP:0200134)5.22221887
5Focal seizures (HP:0007359)4.96147320
6Febrile seizures (HP:0002373)4.76554193
7Visual hallucinations (HP:0002367)4.26772412
8Absence seizures (HP:0002121)4.15596508
9Progressive cerebellar ataxia (HP:0002073)4.01327905
10Hyperventilation (HP:0002883)3.92012429
11Dialeptic seizures (HP:0011146)3.82962272
12Generalized tonic-clonic seizures (HP:0002069)3.59529982
13Neurofibrillary tangles (HP:0002185)3.46726440
14Cerebral hypomyelination (HP:0006808)3.33112065
15Pheochromocytoma (HP:0002666)3.27687789
16Broad-based gait (HP:0002136)3.24279235
17Gait imbalance (HP:0002141)3.20054171
18Gaze-evoked nystagmus (HP:0000640)3.12169231
19Peripheral hypomyelination (HP:0007182)3.06461434
20Intention tremor (HP:0002080)3.01141594
21Neuroendocrine neoplasm (HP:0100634)3.00779130
22Abnormal hair whorl (HP:0010721)2.93613602
23Abnormal eating behavior (HP:0100738)2.90946216
24Congenital primary aphakia (HP:0007707)2.89441464
25Medial flaring of the eyebrow (HP:0010747)2.83870873
26Impaired vibration sensation in the lower limbs (HP:0002166)2.82355435
27Ankle clonus (HP:0011448)2.80714966
28Cerebral inclusion bodies (HP:0100314)2.78904171
29Epileptiform EEG discharges (HP:0011182)2.77449415
30Action tremor (HP:0002345)2.75598858
31Nephrogenic diabetes insipidus (HP:0009806)2.75047969
32Limb dystonia (HP:0002451)2.74387782
33Dysdiadochokinesis (HP:0002075)2.71083656
34Anxiety (HP:0000739)2.70393245
35Truncal ataxia (HP:0002078)2.67945844
36Tetraplegia (HP:0002445)2.66290389
37Amblyopia (HP:0000646)2.64882143
38Neuronal loss in central nervous system (HP:0002529)2.64627369
39Polyphagia (HP:0002591)2.64525910
40Depression (HP:0000716)2.64256536
41EEG with generalized epileptiform discharges (HP:0011198)2.57358824
42Craniofacial dystonia (HP:0012179)2.57028117
43Urinary bladder sphincter dysfunction (HP:0002839)2.56858603
44Poor eye contact (HP:0000817)2.56515852
45Supranuclear gaze palsy (HP:0000605)2.51700306
46Papilledema (HP:0001085)2.50900470
47Hemiplegia (HP:0002301)2.47940387
48Annular pancreas (HP:0001734)2.47938580
49Apathy (HP:0000741)2.45973066
50Insomnia (HP:0100785)2.45881054
51Dysmetria (HP:0001310)2.45283306
52Fetal akinesia sequence (HP:0001989)2.42807863
53CNS hypomyelination (HP:0003429)2.40949930
54Genetic anticipation (HP:0003743)2.39573693
55Morphological abnormality of the pyramidal tract (HP:0002062)2.38435814
56Hypsarrhythmia (HP:0002521)2.38110610
57Rigidity (HP:0002063)2.37399985
58Specific learning disability (HP:0001328)2.36787363
59Diminished motivation (HP:0000745)2.36756553
60Clonus (HP:0002169)2.36281326
61Abnormality of the corticospinal tract (HP:0002492)2.34485637
62Poor suck (HP:0002033)2.34366891
63Failure to thrive in infancy (HP:0001531)2.33840032
64Progressive inability to walk (HP:0002505)2.33680872
65Genital tract atresia (HP:0001827)2.32448708
66Excessive salivation (HP:0003781)2.32382305
67Drooling (HP:0002307)2.32382305
68Vaginal atresia (HP:0000148)2.32084460
69Termporal pattern (HP:0011008)2.31760167
70Insidious onset (HP:0003587)2.31760167
71Acute necrotizing encephalopathy (HP:0006965)2.30754521
72Amyotrophic lateral sclerosis (HP:0007354)2.30512549
73Scanning speech (HP:0002168)2.27616937
74Abnormal social behavior (HP:0012433)2.26831441
75Impaired social interactions (HP:0000735)2.26831441
76Spastic tetraplegia (HP:0002510)2.25441164
77Abnormal mitochondria in muscle tissue (HP:0008316)2.24947880
78Spastic gait (HP:0002064)2.23691003
79Inability to walk (HP:0002540)2.21143452
80Muscular hypotonia of the trunk (HP:0008936)2.19363561
81Abnormality of binocular vision (HP:0011514)2.17161490
82Diplopia (HP:0000651)2.17161490
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.16813838
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16813838
85Hand muscle atrophy (HP:0009130)2.15560657
86Urinary urgency (HP:0000012)2.14205617
87Blue irides (HP:0000635)2.12184470
88Abnormality of the labia minora (HP:0012880)2.11674223
89Rapidly progressive (HP:0003678)2.11485849
90Split foot (HP:0001839)2.10980885
91Poor coordination (HP:0002370)2.10687745
92Diminished movement (HP:0002374)2.10175922
93Obstructive sleep apnea (HP:0002870)2.09130139
94Progressive macrocephaly (HP:0004481)2.08811156
95Absent speech (HP:0001344)2.07106039
96Abnormality of the lower motor neuron (HP:0002366)2.05510885
97Mutism (HP:0002300)2.05195935
98Impaired vibratory sensation (HP:0002495)2.04597764
99Bradykinesia (HP:0002067)2.03733379
100Spastic tetraparesis (HP:0001285)2.02172579
101Postural instability (HP:0002172)2.01924908
102Impaired smooth pursuit (HP:0007772)2.01400596
103Choreoathetosis (HP:0001266)2.00417370
104Torticollis (HP:0000473)1.97232913
105Abnormal ciliary motility (HP:0012262)1.96822513
106Absent/shortened dynein arms (HP:0200106)1.95168069
107Dynein arm defect of respiratory motile cilia (HP:0012255)1.95168069
108Protruding tongue (HP:0010808)1.94830469
109Agitation (HP:0000713)1.94575914
110Focal dystonia (HP:0004373)1.94454587
111Dysmetric saccades (HP:0000641)1.94156818
112Hemiparesis (HP:0001269)1.90917049
113Esotropia (HP:0000565)1.90863490
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90357796
115Akinesia (HP:0002304)1.89994791
116Hypokinesia (HP:0002375)1.89862500
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88950504
118Hyperthyroidism (HP:0000836)1.88054629
119Lower limb muscle weakness (HP:0007340)1.87793726
120Delusions (HP:0000746)1.86494344
121Neoplasm of the peripheral nervous system (HP:0100007)1.84579774
122Generalized myoclonic seizures (HP:0002123)1.83539809
123Sleep apnea (HP:0010535)1.83533967
124Gait ataxia (HP:0002066)1.83096453
125Hypoplasia of the corpus callosum (HP:0002079)1.81768280
126Abnormal gallbladder physiology (HP:0012438)1.81035863
127Cholecystitis (HP:0001082)1.81035863
128Incomplete penetrance (HP:0003829)1.78037180
129Hypoventilation (HP:0002791)1.77801523
130Dyskinesia (HP:0100660)1.77536078
131Growth hormone excess (HP:0000845)1.75709318
132Status epilepticus (HP:0002133)1.75670497
133Distal upper limb amyotrophy (HP:0007149)1.75614995
134Upper limb amyotrophy (HP:0009129)1.75614995
135Abnormal respiratory motile cilium physiology (HP:0012261)1.74659388
136Mitochondrial inheritance (HP:0001427)1.74393590
137Oligomenorrhea (HP:0000876)1.72712437
138Retinal dysplasia (HP:0007973)1.72442988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.67428349
2NTRK33.82266035
3EPHA43.28525621
4MAP3K43.11591148
5MAP2K73.10085317
6MARK13.02376313
7MAP3K122.87622797
8MAP3K92.60757900
9MINK12.36090997
10CDK192.33984915
11DAPK22.27944269
12PRPF4B2.02410212
13PLK22.01387567
14AKT31.80365931
15MAP2K41.80259507
16DAPK11.73551885
17NTRK21.67335241
18PAK61.59676319
19ARAF1.58522083
20OXSR11.55744598
21TESK11.53552487
22MAPK131.50856626
23GRK51.46520531
24CCNB11.40230495
25PNCK1.34731075
26TNIK1.34482894
27PRKCG1.33863087
28CDK51.33018390
29CSNK1G31.31559842
30SGK4941.28777146
31SGK2231.28777146
32NTRK11.27531338
33PRKD31.23549270
34KSR11.16612485
35TSSK61.14828214
36KSR21.14373655
37NME11.13942823
38CAMKK21.11902628
39MAP3K111.09960538
40CAMK2A1.09640495
41CAMKK11.09560382
42SGK21.07369120
43CAMK2B1.05681073
44UHMK11.04297762
45DYRK21.02552204
46RIPK41.01979227
47TYRO31.01384856
48BRAF0.97914157
49RIPK10.95754464
50CSNK1A1L0.95714578
51PHKG20.95669040
52PHKG10.95669040
53MAP4K20.93854526
54CDK180.91565212
55BMPR20.91398493
56PINK10.91194964
57SIK30.88507652
58CDK140.87927254
59FES0.86857113
60CDK150.85736082
61TESK20.85382310
62CSNK1G10.82992861
63BCR0.82960738
64PRKCE0.81941291
65BRSK10.78197226
66WNK30.74734331
67CDK11A0.74318837
68CAMK2D0.74292920
69STK380.73602768
70BCKDK0.73460355
71NEK60.72123155
72MAPKAPK50.71347491
73DYRK1A0.70585336
74PTK2B0.69957581
75ICK0.66516297
76PRKCH0.64281195
77SGK30.63756295
78CAMK10.63429347
79CAMK2G0.62838092
80CSNK1G20.62831334
81MAPK120.62338475
82DYRK1B0.61822745
83CAMK40.61390777
84PDK30.60344805
85PDK40.60344805
86MAP3K20.58944489
87NEK10.58188107
88ADRBK20.57213136
89SIK20.57046648
90SGK10.56107971
91FER0.54003217
92GRK70.53862488
93MAPK100.53063715
94PAK30.52753141
95TNK20.51305478
96LMTK20.51258932
97MAP3K130.50922275
98CDC42BPA0.50888750
99ALK0.47853282
100ADRBK10.47403468
101LIMK10.46721638
102STK110.46710569
103TRIM280.45955236
104DAPK30.45143943
105ROCK20.44462348
106STK390.43482431
107STK160.42665495
108SCYL20.41702450
109PKN10.41497282
110PIM20.39994521
111RAF10.39866822
112PDK10.39502179
113PRKCZ0.39244523
114RET0.38416775
115PRKACA0.37320818
116MUSK0.37199464
117CDK30.36810466
118TAOK10.36513131
119PRKAA10.35886436
120LATS20.35685585
121FYN0.35517946
122RPS6KA30.35461148
123FGFR20.34694005
124ERBB30.34328209
125CSNK1D0.34322943
126PDPK10.33884615
127IRAK20.33445037
128MARK20.33319062
129MAP2K10.32663766
130CSNK1A10.31021876
131EPHA30.28209542

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047214.16398192
2Nicotine addiction_Homo sapiens_hsa050334.14173419
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85947991
4GABAergic synapse_Homo sapiens_hsa047272.85909291
5Olfactory transduction_Homo sapiens_hsa047402.75488923
6* Collecting duct acid secretion_Homo sapiens_hsa049662.70312533
7Morphine addiction_Homo sapiens_hsa050322.64086416
8Circadian entrainment_Homo sapiens_hsa047132.61694994
9Glutamatergic synapse_Homo sapiens_hsa047242.38902844
10Amphetamine addiction_Homo sapiens_hsa050312.38822650
11Long-term potentiation_Homo sapiens_hsa047202.33254792
12Dopaminergic synapse_Homo sapiens_hsa047282.15360478
13Insulin secretion_Homo sapiens_hsa049112.06442249
14Taste transduction_Homo sapiens_hsa047422.03119864
15Salivary secretion_Homo sapiens_hsa049701.89671452
16Phototransduction_Homo sapiens_hsa047441.88605904
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88180896
18Serotonergic synapse_Homo sapiens_hsa047261.85485668
19* Vibrio cholerae infection_Homo sapiens_hsa051101.83215979
20Cholinergic synapse_Homo sapiens_hsa047251.75388659
21* Oxidative phosphorylation_Homo sapiens_hsa001901.72423090
22Vitamin B6 metabolism_Homo sapiens_hsa007501.71066594
23Long-term depression_Homo sapiens_hsa047301.66710500
24Cocaine addiction_Homo sapiens_hsa050301.62188768
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58197853
26Gastric acid secretion_Homo sapiens_hsa049711.57505556
27Renin secretion_Homo sapiens_hsa049241.53997086
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52320016
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51282388
30Calcium signaling pathway_Homo sapiens_hsa040201.50112053
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49290810
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43406926
33Oxytocin signaling pathway_Homo sapiens_hsa049211.38560720
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35973367
35Parkinsons disease_Homo sapiens_hsa050121.25655528
36* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21411453
37Cardiac muscle contraction_Homo sapiens_hsa042601.20690052
38Alzheimers disease_Homo sapiens_hsa050101.17689140
39Gap junction_Homo sapiens_hsa045401.16249361
40GnRH signaling pathway_Homo sapiens_hsa049121.11158373
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10901002
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09511736
43cAMP signaling pathway_Homo sapiens_hsa040241.08577989
44Axon guidance_Homo sapiens_hsa043601.03338175
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03069365
46Arginine and proline metabolism_Homo sapiens_hsa003300.96317462
47Bile secretion_Homo sapiens_hsa049760.95513859
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95494212
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92525668
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89766824
51Huntingtons disease_Homo sapiens_hsa050160.88787828
52Type II diabetes mellitus_Homo sapiens_hsa049300.87045495
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85776720
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84075358
55ErbB signaling pathway_Homo sapiens_hsa040120.83440354
56Melanogenesis_Homo sapiens_hsa049160.82649609
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82547063
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.82345697
59Estrogen signaling pathway_Homo sapiens_hsa049150.80213282
60Type I diabetes mellitus_Homo sapiens_hsa049400.76014947
61Arginine biosynthesis_Homo sapiens_hsa002200.71941079
62Oocyte meiosis_Homo sapiens_hsa041140.71698744
63Sulfur relay system_Homo sapiens_hsa041220.71106789
64Biosynthesis of amino acids_Homo sapiens_hsa012300.70860772
65beta-Alanine metabolism_Homo sapiens_hsa004100.69425582
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68952831
67* Rheumatoid arthritis_Homo sapiens_hsa053230.68271220
68Glioma_Homo sapiens_hsa052140.67911511
69Fatty acid biosynthesis_Homo sapiens_hsa000610.65313322
70Pancreatic secretion_Homo sapiens_hsa049720.64060504
71Fatty acid elongation_Homo sapiens_hsa000620.62955790
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61950986
73Fatty acid metabolism_Homo sapiens_hsa012120.60402017
74Circadian rhythm_Homo sapiens_hsa047100.59387141
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58260481
76Phenylalanine metabolism_Homo sapiens_hsa003600.57329467
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56058311
78Alcoholism_Homo sapiens_hsa050340.55713791
79MAPK signaling pathway_Homo sapiens_hsa040100.55673937
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55270410
81Thyroid hormone synthesis_Homo sapiens_hsa049180.53485462
82Ras signaling pathway_Homo sapiens_hsa040140.51414184
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50655125
84AMPK signaling pathway_Homo sapiens_hsa041520.50337541
85Dilated cardiomyopathy_Homo sapiens_hsa054140.50164383
86* Phagosome_Homo sapiens_hsa041450.50089701
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49910110
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.43765231
89Glucagon signaling pathway_Homo sapiens_hsa049220.43011261
90Histidine metabolism_Homo sapiens_hsa003400.42225261
91Carbon metabolism_Homo sapiens_hsa012000.41946223
92Inositol phosphate metabolism_Homo sapiens_hsa005620.41633368
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40060954
94Regulation of autophagy_Homo sapiens_hsa041400.39763232
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.39233880
96Ovarian steroidogenesis_Homo sapiens_hsa049130.39130102
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39027614
98Folate biosynthesis_Homo sapiens_hsa007900.38952562
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38648997
100Choline metabolism in cancer_Homo sapiens_hsa052310.38606851
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36649102
102Butanoate metabolism_Homo sapiens_hsa006500.36596091
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.34804979
104Dorso-ventral axis formation_Homo sapiens_hsa043200.34361620
105Peroxisome_Homo sapiens_hsa041460.33908878
106Steroid biosynthesis_Homo sapiens_hsa001000.32922192
107Endocytosis_Homo sapiens_hsa041440.31103757
108Pyruvate metabolism_Homo sapiens_hsa006200.30958679
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30549572
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30523241
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30125896
112Rap1 signaling pathway_Homo sapiens_hsa040150.29692855
113Wnt signaling pathway_Homo sapiens_hsa043100.29148369
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.28009079
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.26230322
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26182834
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24572010
118Melanoma_Homo sapiens_hsa052180.23832545
119Prion diseases_Homo sapiens_hsa050200.23081714
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.22574628
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22334299
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21513210
123Insulin signaling pathway_Homo sapiens_hsa049100.18899573

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