ATP6V1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.33671238
2neuron cell-cell adhesion (GO:0007158)5.19732632
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.07358616
4vocalization behavior (GO:0071625)5.01625224
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.63802082
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.53194725
7glutamate secretion (GO:0014047)4.46192731
8gamma-aminobutyric acid signaling pathway (GO:0007214)4.45993455
9protein localization to synapse (GO:0035418)4.37720747
10regulation of synaptic vesicle exocytosis (GO:2000300)4.36813558
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35297137
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.34049369
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33782551
14glutamate receptor signaling pathway (GO:0007215)4.31465056
15regulation of glutamate receptor signaling pathway (GO:1900449)4.31261272
16neuronal action potential propagation (GO:0019227)4.26336537
17locomotory exploration behavior (GO:0035641)4.24960285
18negative regulation of synaptic transmission, GABAergic (GO:0032229)4.17079492
19pyrimidine nucleobase catabolic process (GO:0006208)4.08105612
20neuron-neuron synaptic transmission (GO:0007270)4.07235057
21neuron recognition (GO:0008038)4.07198583
22presynaptic membrane assembly (GO:0097105)3.98271500
23exploration behavior (GO:0035640)3.88476479
24response to histamine (GO:0034776)3.87667331
25regulation of synaptic vesicle transport (GO:1902803)3.87603596
26neurotransmitter secretion (GO:0007269)3.87276999
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.84609189
28synaptic transmission, glutamatergic (GO:0035249)3.80510616
29synaptic vesicle maturation (GO:0016188)3.79812522
30presynaptic membrane organization (GO:0097090)3.75248751
31long-term synaptic potentiation (GO:0060291)3.72679786
32nucleobase catabolic process (GO:0046113)3.64094903
33synaptic vesicle endocytosis (GO:0048488)3.63543823
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61999284
35regulation of glutamate secretion (GO:0014048)3.56008312
36regulation of neuronal synaptic plasticity (GO:0048168)3.55204809
37proline transport (GO:0015824)3.54597199
38neurotransmitter transport (GO:0006836)3.52523395
39transmission of nerve impulse (GO:0019226)3.51841087
40regulation of postsynaptic membrane potential (GO:0060078)3.48035711
41negative regulation of neurotransmitter transport (GO:0051589)3.47016223
42axonal fasciculation (GO:0007413)3.46402278
43* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.44919256
44* ATP hydrolysis coupled proton transport (GO:0015991)3.44919256
45gamma-aminobutyric acid transport (GO:0015812)3.41650243
46mating behavior (GO:0007617)3.32444020
47negative regulation of dendrite development (GO:2000171)3.31796614
48long-term memory (GO:0007616)3.29324660
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28987916
50nerve growth factor signaling pathway (GO:0038180)3.28971054
51regulation of vesicle fusion (GO:0031338)3.28912051
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28440177
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27493730
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.27151608
55cellular potassium ion homeostasis (GO:0030007)3.25212677
56* transferrin transport (GO:0033572)3.25046825
57regulation of synaptic plasticity (GO:0048167)3.23422117
58neurotransmitter-gated ion channel clustering (GO:0072578)3.21513991
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.21179146
60regulation of neurotransmitter levels (GO:0001505)3.18292622
61behavioral response to cocaine (GO:0048148)3.17916481
62protein localization to cilium (GO:0061512)3.17619648
63layer formation in cerebral cortex (GO:0021819)3.17517249
64startle response (GO:0001964)3.14778922
65behavioral fear response (GO:0001662)3.13855341
66behavioral defense response (GO:0002209)3.13855341
67positive regulation of synapse maturation (GO:0090129)3.13635306
68positive regulation of membrane potential (GO:0045838)3.11921112
69postsynaptic membrane organization (GO:0001941)3.11448647
70positive regulation of synapse assembly (GO:0051965)3.09522958
71detection of calcium ion (GO:0005513)3.09209874
72regulation of neurotransmitter secretion (GO:0046928)3.07645249
73negative regulation of dendrite morphogenesis (GO:0050774)3.06730961
74fear response (GO:0042596)3.03352266
75cerebellar granule cell differentiation (GO:0021707)3.03216403
76* ferric iron transport (GO:0015682)3.03188694
77* trivalent inorganic cation transport (GO:0072512)3.03188694
78establishment of synaptic vesicle localization (GO:0097480)3.02301057
79synaptic vesicle transport (GO:0048489)3.02301057
80negative regulation of amino acid transport (GO:0051956)3.00735487
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00259326
82dendritic spine morphogenesis (GO:0060997)2.99324040
83righting reflex (GO:0060013)2.98835401
84regulation of synapse structural plasticity (GO:0051823)2.98468645
85synaptic transmission, dopaminergic (GO:0001963)2.98046311
86vesicle transport along microtubule (GO:0047496)2.96832832
87regulation of dendritic spine morphogenesis (GO:0061001)2.96233220
88synapse assembly (GO:0007416)2.95852466
89membrane depolarization (GO:0051899)2.90998943
90regulation of clathrin-mediated endocytosis (GO:2000369)2.90644328
91learning (GO:0007612)2.89917734
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88815162
93synaptic transmission (GO:0007268)2.88009943
94* phagosome maturation (GO:0090382)2.85788595
95ganglioside metabolic process (GO:0001573)2.84250055
96regulation of neurotransmitter transport (GO:0051588)2.83659668
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.82771300
98regulation of protein kinase A signaling (GO:0010738)2.82569461
99dopamine biosynthetic process (GO:0042416)2.82044145
100positive regulation of neurotransmitter secretion (GO:0001956)2.81863246
101establishment of vesicle localization (GO:0051650)2.80189654
102acidic amino acid transport (GO:0015800)2.79308233
103regulation of synaptic transmission (GO:0050804)2.78021904
104neuron remodeling (GO:0016322)2.77532101
105negative regulation of synaptic transmission (GO:0050805)2.77399963
106positive regulation of synaptic transmission (GO:0050806)2.76282912
107synapse organization (GO:0050808)2.75525797
108regulation of dendritic spine development (GO:0060998)2.75493347
109membrane hyperpolarization (GO:0060081)2.75321204
110peptidyl-cysteine modification (GO:0018198)2.75224042
111long term synaptic depression (GO:0060292)2.75072516
112dendritic spine organization (GO:0097061)2.74629648
113clathrin coat assembly (GO:0048268)2.74370742
114positive regulation of neurotransmitter transport (GO:0051590)2.73341629
115glycosphingolipid biosynthetic process (GO:0006688)2.72976701
116response to dietary excess (GO:0002021)2.69062167
117melanosome transport (GO:0032402)2.66000508
118negative regulation of neurotransmitter secretion (GO:0046929)2.64900362
119vesicle docking (GO:0048278)2.64729958
120neurotransmitter uptake (GO:0001504)2.64388534
121positive regulation of exocytosis (GO:0045921)2.63561493
122establishment of melanosome localization (GO:0032401)2.63174890
123regulation of feeding behavior (GO:0060259)2.61862015
124vesicle docking involved in exocytosis (GO:0006904)2.60915110
125regulation of exocytosis (GO:0017157)2.58145830
126glycosphingolipid catabolic process (GO:0046479)2.58027552
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57149822
128pigment granule transport (GO:0051904)2.56578203
129dendrite morphogenesis (GO:0048813)2.56143937
130signal release (GO:0023061)2.55450907
131establishment of pigment granule localization (GO:0051905)2.54285103
132cellular response to ethanol (GO:0071361)2.53690794
133oligosaccharide catabolic process (GO:0009313)2.53449972
134C4-dicarboxylate transport (GO:0015740)2.53430741
135* iron ion transport (GO:0006826)2.52623121
136L-glutamate transport (GO:0015813)2.52250781
137regulation of cAMP-dependent protein kinase activity (GO:2000479)2.50603984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.64357634
2GBX2_23144817_ChIP-Seq_PC3_Human4.19841125
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08915365
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98477208
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88903326
6TAF15_26573619_Chip-Seq_HEK293_Human2.79324557
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65066274
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48507701
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46298098
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46298098
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44748184
12REST_21632747_ChIP-Seq_MESCs_Mouse2.44617979
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42573006
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34989299
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34256627
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28567534
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28378627
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.26595238
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.22753623
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.21297312
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14955620
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.97551014
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97515386
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93195104
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.92547793
26SMAD4_21799915_ChIP-Seq_A2780_Human1.91667815
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.89141995
28* P300_19829295_ChIP-Seq_ESCs_Human1.88013434
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.87328556
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86883202
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.86118517
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84558342
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84346159
34AR_21572438_ChIP-Seq_LNCaP_Human1.81007412
35DROSHA_22980978_ChIP-Seq_HELA_Human1.79630289
36* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78124167
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77175825
38FUS_26573619_Chip-Seq_HEK293_Human1.71514491
39VDR_22108803_ChIP-Seq_LS180_Human1.69120802
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66170596
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65751480
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64779051
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64211500
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63655869
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62847394
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62368243
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62118777
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61636301
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60909861
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.58540428
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58259744
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.57305496
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.56440598
54ZNF274_21170338_ChIP-Seq_K562_Hela1.53340483
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51682857
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50743591
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50610177
58IGF1R_20145208_ChIP-Seq_DFB_Human1.48538080
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48501030
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47406266
61AR_25329375_ChIP-Seq_VCAP_Human1.46863033
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.42974126
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.41995436
64* EWS_26573619_Chip-Seq_HEK293_Human1.41561844
65ER_23166858_ChIP-Seq_MCF-7_Human1.41017523
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39503654
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39371492
68CBP_20019798_ChIP-Seq_JUKART_Human1.39371492
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.38592886
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36047927
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.33919036
72* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33847799
73P300_18555785_Chip-Seq_ESCs_Mouse1.32881770
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.31768965
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31341748
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30802637
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.30446462
78SOX2_18555785_Chip-Seq_ESCs_Mouse1.29875155
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29628881
80STAT3_23295773_ChIP-Seq_U87_Human1.28600719
81* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28464363
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27666322
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24898701
84RNF2_27304074_Chip-Seq_NSC_Mouse1.23437793
85NMYC_18555785_Chip-Seq_ESCs_Mouse1.23281791
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22677559
87JUN_21703547_ChIP-Seq_K562_Human1.22380702
88GATA1_22025678_ChIP-Seq_K562_Human1.21612328
89* PRDM14_20953172_ChIP-Seq_ESCs_Human1.19389130
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.19143311
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17682039
92TCF4_23295773_ChIP-Seq_U87_Human1.17250009
93RUNX2_22187159_ChIP-Seq_PCA_Human1.17215942
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.17125133
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.16734521
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.16535229
97TP53_18474530_ChIP-ChIP_U2OS_Human1.16309185
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.15866812
99TP53_16413492_ChIP-PET_HCT116_Human1.14927389
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.14801737
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.14663296
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14206789
103PU1_27457419_Chip-Seq_LIVER_Mouse1.13310905
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.13122048
105* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13045153
106HTT_18923047_ChIP-ChIP_STHdh_Human1.11380804
107TCF4_22108803_ChIP-Seq_LS180_Human1.11366138
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11266263
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10429495
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09290304
111AHR_22903824_ChIP-Seq_MCF-7_Human1.09060757
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08462857
113BCAT_22108803_ChIP-Seq_LS180_Human1.07483549
114SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06421944
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06198866
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05081654
117RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05026352
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.04885806
119SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04463556
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03933774
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03341805
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02988790
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01971628
124AR_19668381_ChIP-Seq_PC3_Human1.01639417
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00958972
126RING1B_27294783_Chip-Seq_ESCs_Mouse0.98931735
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98647014
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97872498
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97872498
130KDM2B_26808549_Chip-Seq_REH_Human0.96423696
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95880776
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92759393
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.92539812
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92289125
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.91985051
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91299377
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89524758
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89371988
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89371988
140P53_22387025_ChIP-Seq_ESCs_Mouse0.89220584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.72327172
2MP0004859_abnormal_synaptic_plasticity5.33503589
3MP0003635_abnormal_synaptic_transmissio3.92565588
4MP0009745_abnormal_behavioral_response3.46960123
5MP0002064_seizures3.40555943
6MP0009046_muscle_twitch3.33301012
7MP0004270_analgesia3.25855769
8MP0002063_abnormal_learning/memory/cond3.19377812
9MP0001968_abnormal_touch/_nociception3.13661240
10MP0002572_abnormal_emotion/affect_behav2.87778271
11MP0002736_abnormal_nociception_after2.77777422
12MP0002272_abnormal_nervous_system2.68225905
13MP0003195_calcinosis2.66558962
14MP0001501_abnormal_sleep_pattern2.64123149
15MP0001440_abnormal_grooming_behavior2.63734321
16MP0002734_abnormal_mechanical_nocicepti2.49357771
17MP0002735_abnormal_chemical_nociception2.45970226
18MP0001486_abnormal_startle_reflex2.38744624
19MP0003329_amyloid_beta_deposits2.24531316
20MP0006276_abnormal_autonomic_nervous2.24259976
21MP0010234_abnormal_vibrissa_follicle2.21421940
22MP0002067_abnormal_sensory_capabilities2.15237573
23MP0005423_abnormal_somatic_nervous2.12118434
24MP0001529_abnormal_vocalization2.07366099
25MP0002733_abnormal_thermal_nociception2.04625884
26MP0001970_abnormal_pain_threshold1.98273226
27MP0002822_catalepsy1.93470995
28MP0001905_abnormal_dopamine_level1.92659955
29MP0004924_abnormal_behavior1.86684899
30MP0005386_behavior/neurological_phenoty1.86684899
31MP0000778_abnormal_nervous_system1.85343824
32MP0002184_abnormal_innervation1.79724506
33MP0002102_abnormal_ear_morphology1.68480903
34MP0002837_dystrophic_cardiac_calcinosis1.65941955
35MP0009780_abnormal_chondrocyte_physiolo1.65666985
36MP0001984_abnormal_olfaction1.62968173
37MP0002557_abnormal_social/conspecific_i1.61796997
38MP0008569_lethality_at_weaning1.50301079
39MP0004142_abnormal_muscle_tone1.49428730
40MP0001188_hyperpigmentation1.47586477
41MP0003121_genomic_imprinting1.45565378
42MP0004811_abnormal_neuron_physiology1.44040880
43MP0002066_abnormal_motor_capabilities/c1.43377219
44MP0000015_abnormal_ear_pigmentation1.40164761
45MP0000604_amyloidosis1.36844491
46MP0000955_abnormal_spinal_cord1.36385480
47MP0002882_abnormal_neuron_morphology1.35626939
48MP0003879_abnormal_hair_cell1.34953405
49MP0010386_abnormal_urinary_bladder1.34226208
50MP0003122_maternal_imprinting1.34080370
51MP0004858_abnormal_nervous_system1.34026259
52MP0004742_abnormal_vestibular_system1.32547519
53MP0005248_abnormal_Harderian_gland1.29153344
54MP0002909_abnormal_adrenal_gland1.29053113
55MP0005167_abnormal_blood-brain_barrier1.27393285
56MP0005253_abnormal_eye_physiology1.26975162
57MP0004885_abnormal_endolymph1.26070554
58MP0003633_abnormal_nervous_system1.25528156
59MP0005646_abnormal_pituitary_gland1.24771262
60MP0003631_nervous_system_phenotype1.17267045
61MP0002876_abnormal_thyroid_physiology1.16151139
62MP0000920_abnormal_myelination1.15893119
63MP0001502_abnormal_circadian_rhythm1.14646843
64MP0006082_CNS_inflammation1.12981404
65MP0002229_neurodegeneration1.12895230
66MP0005551_abnormal_eye_electrophysiolog1.10982007
67MP0010678_abnormal_skin_adnexa1.09600397
68MP0003787_abnormal_imprinting1.09595670
69MP0000371_diluted_coat_color1.09201057
70MP0005645_abnormal_hypothalamus_physiol1.08069108
71MP0003634_abnormal_glial_cell1.07625752
72MP0003690_abnormal_glial_cell1.05719341
73MP0005174_abnormal_tail_pigmentation1.05058060
74MP0000372_irregular_coat_pigmentation1.04150911
75MP0008877_abnormal_DNA_methylation1.03322841
76MP0003632_abnormal_nervous_system1.02990306
77MP0005171_absent_coat_pigmentation0.99739131
78MP0002152_abnormal_brain_morphology0.99033723
79MP0001963_abnormal_hearing_physiology0.96944402
80MP0002090_abnormal_vision0.96749723
81MP0004484_altered_response_of0.95143027
82MP0005535_abnormal_body_temperature0.94672743
83MP0002163_abnormal_gland_morphology0.94587959
84MP0000013_abnormal_adipose_tissue0.93329004
85MP0000647_abnormal_sebaceous_gland0.90082154
86MP0003656_abnormal_erythrocyte_physiolo0.89690630
87MP0008874_decreased_physiological_sensi0.87427256
88MP0008872_abnormal_physiological_respon0.87294235
89MP0005409_darkened_coat_color0.87292901
90MP0000427_abnormal_hair_cycle0.87080212
91MP0002069_abnormal_eating/drinking_beha0.86447868
92MP0005187_abnormal_penis_morphology0.83001450
93MP0001324_abnormal_eye_pigmentation0.81727574
94MP0004147_increased_porphyrin_level0.79950476
95MP0005058_abnormal_lysosome_morphology0.79883630
96MP0001756_abnormal_urination0.78896891
97MP0002752_abnormal_somatic_nervous0.78850642
98MP0001177_atelectasis0.77827103
99MP0004145_abnormal_muscle_electrophysio0.77556674
100MP0003123_paternal_imprinting0.75010359
101MP0003172_abnormal_lysosome_physiology0.74210366
102MP0002638_abnormal_pupillary_reflex0.73919470
103MP0005623_abnormal_meninges_morphology0.72149614
104MP0001664_abnormal_digestion0.71594884
105MP0005394_taste/olfaction_phenotype0.71435622
106MP0005499_abnormal_olfactory_system0.71435622
107MP0000751_myopathy0.70951304
108MP0005367_renal/urinary_system_phenotyp0.70478236
109MP0000516_abnormal_urinary_system0.70478236
110MP0004043_abnormal_pH_regulation0.68457879
111MP0004085_abnormal_heartbeat0.67121784
112MP0001986_abnormal_taste_sensitivity0.66896235
113MP0005408_hypopigmentation0.66423683
114MP0002693_abnormal_pancreas_physiology0.64903305
115MP0000631_abnormal_neuroendocrine_gland0.62960252
116MP0000569_abnormal_digit_pigmentation0.60427756
117MP0001485_abnormal_pinna_reflex0.59409974
118MP0000026_abnormal_inner_ear0.58780076
119MP0001943_abnormal_respiration0.56736055
120MP0004215_abnormal_myocardial_fiber0.54710594
121MP0003183_abnormal_peptide_metabolism0.54414245
122MP0005379_endocrine/exocrine_gland_phen0.52750137
123MP0001765_abnormal_ion_homeostasis0.52723180
124MP0004510_myositis0.52492811
125MP0003075_altered_response_to0.48703024
126MP0005410_abnormal_fertilization0.48444060
127MP0003956_abnormal_body_size0.44291973
128MP0004233_abnormal_muscle_weight0.44230201
129MP0006072_abnormal_retinal_apoptosis0.43864079
130MP0010770_preweaning_lethality0.42836953

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.68153779
2Focal seizures (HP:0007359)5.47351269
3Atonic seizures (HP:0010819)5.28607049
4Visual hallucinations (HP:0002367)5.22053475
5Epileptic encephalopathy (HP:0200134)4.84111159
6Myokymia (HP:0002411)4.63882098
7Absence seizures (HP:0002121)4.61732866
8Dialeptic seizures (HP:0011146)4.38157145
9Hyperventilation (HP:0002883)4.37497100
10Febrile seizures (HP:0002373)4.32027712
11Cerebral inclusion bodies (HP:0100314)4.31636546
12Abnormality of glycolipid metabolism (HP:0010969)4.16404079
13Abnormality of liposaccharide metabolism (HP:0010968)4.16404079
14Abnormality of glycosphingolipid metabolism (HP:0004343)4.16404079
15Neurofibrillary tangles (HP:0002185)3.97844225
16Generalized tonic-clonic seizures (HP:0002069)3.89841113
17Supranuclear gaze palsy (HP:0000605)3.80631841
18Progressive cerebellar ataxia (HP:0002073)3.78084605
19Broad-based gait (HP:0002136)3.46605314
20Truncal ataxia (HP:0002078)3.15269152
21Progressive inability to walk (HP:0002505)3.09403508
22Amblyopia (HP:0000646)3.02861368
23Papillary thyroid carcinoma (HP:0002895)3.00780285
24Diplopia (HP:0000651)2.99032387
25Abnormality of binocular vision (HP:0011514)2.99032387
26Disinhibition (HP:0000734)2.95508798
27Excessive salivation (HP:0003781)2.92743136
28Drooling (HP:0002307)2.92743136
29Pheochromocytoma (HP:0002666)2.92426090
30Vacuolated lymphocytes (HP:0001922)2.88651672
31Dysmetria (HP:0001310)2.87718834
32Gaze-evoked nystagmus (HP:0000640)2.81957281
33Abnormal eating behavior (HP:0100738)2.81386311
34Limb dystonia (HP:0002451)2.80262984
35Insidious onset (HP:0003587)2.79770572
36Termporal pattern (HP:0011008)2.79770572
37Apathy (HP:0000741)2.78979328
38Polyphagia (HP:0002591)2.78569339
39Action tremor (HP:0002345)2.74094602
40Dysdiadochokinesis (HP:0002075)2.72876363
41Mutism (HP:0002300)2.72598519
42Anxiety (HP:0000739)2.70172467
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.68228370
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.68228370
45Neuroendocrine neoplasm (HP:0100634)2.67997815
46Abnormality of the corticospinal tract (HP:0002492)2.67555358
47Hypothermia (HP:0002045)2.67108715
48Diminished motivation (HP:0000745)2.65674375
49Absent speech (HP:0001344)2.64114525
50Inability to walk (HP:0002540)2.60241349
51Poor eye contact (HP:0000817)2.58923475
52Thyroid carcinoma (HP:0002890)2.57207338
53Acute necrotizing encephalopathy (HP:0006965)2.56165913
54Epileptiform EEG discharges (HP:0011182)2.54370991
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.48252685
56Impaired vibration sensation in the lower limbs (HP:0002166)2.46849894
57Abnormal social behavior (HP:0012433)2.42351305
58Impaired social interactions (HP:0000735)2.42351305
59Progressive macrocephaly (HP:0004481)2.41892002
60Generalized myoclonic seizures (HP:0002123)2.41185609
61Depression (HP:0000716)2.40998793
62Hemiparesis (HP:0001269)2.40699460
63Gait imbalance (HP:0002141)2.40583432
64EEG with generalized epileptiform discharges (HP:0011198)2.36252239
65Neuronal loss in central nervous system (HP:0002529)2.33508125
66Amyotrophic lateral sclerosis (HP:0007354)2.32584267
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.31914862
68Abnormal mitochondria in muscle tissue (HP:0008316)2.31452740
69Delusions (HP:0000746)2.30572113
70Muscular hypotonia of the trunk (HP:0008936)2.28430018
71Scanning speech (HP:0002168)2.28162408
72Increased circulating renin level (HP:0000848)2.26795435
73Agnosia (HP:0010524)2.26695794
74Spinal muscular atrophy (HP:0007269)2.24330383
75Urinary bladder sphincter dysfunction (HP:0002839)2.23201669
76Akinesia (HP:0002304)2.21493252
77Retinal atrophy (HP:0001105)2.21344888
78Psychosis (HP:0000709)2.20730196
79Abnormality of the anterior horn cell (HP:0006802)2.18453167
80Degeneration of anterior horn cells (HP:0002398)2.18453167
81Bradykinesia (HP:0002067)2.17853975
82Ankle clonus (HP:0011448)2.17713673
83Loss of speech (HP:0002371)2.15505151
84Spastic gait (HP:0002064)2.14523334
85Hyperinsulinemic hypoglycemia (HP:0000825)2.14217461
86Hypsarrhythmia (HP:0002521)2.13625765
87Tetraparesis (HP:0002273)2.12406783
88Postural instability (HP:0002172)2.11263464
89Protruding tongue (HP:0010808)2.10956696
90Blue irides (HP:0000635)2.10468625
91Fetal akinesia sequence (HP:0001989)2.10341676
92Clumsiness (HP:0002312)2.09684950
93Medial flaring of the eyebrow (HP:0010747)2.08603061
94Generalized hypopigmentation of hair (HP:0011358)2.08578041
95Congenital primary aphakia (HP:0007707)2.08518934
96Mitochondrial inheritance (HP:0001427)2.07151680
97Hypomagnesemia (HP:0002917)2.05560633
98Abnormality of salivation (HP:0100755)2.05196274
99Intestinal atresia (HP:0011100)2.02127492
100Urinary urgency (HP:0000012)2.01914829
101Epidermoid cyst (HP:0200040)2.01362848
102Intention tremor (HP:0002080)2.00659314
103Paraplegia (HP:0010550)1.97617691
104Hypokalemic alkalosis (HP:0001949)1.96963276
105Hypoglycemic coma (HP:0001325)1.96944075
106Inappropriate behavior (HP:0000719)1.96287919
107Status epilepticus (HP:0002133)1.95813966
108Nephrogenic diabetes insipidus (HP:0009806)1.95503195
109Impaired smooth pursuit (HP:0007772)1.95258469
110Gait ataxia (HP:0002066)1.94317643
111Esotropia (HP:0000565)1.94085030
112Lower limb muscle weakness (HP:0007340)1.92663467
113Genital tract atresia (HP:0001827)1.92544653
114Neoplasm of the adrenal cortex (HP:0100641)1.92485953
115Rapidly progressive (HP:0003678)1.91896031
116Vaginal atresia (HP:0000148)1.91552920
117Widely spaced teeth (HP:0000687)1.91057335
118Hypoglycemic seizures (HP:0002173)1.90372999
119Retinal dysplasia (HP:0007973)1.90259757
120Stereotypic behavior (HP:0000733)1.89992708
121Neoplasm of the adrenal gland (HP:0100631)1.89152399
122Cerebral hemorrhage (HP:0001342)1.88147615
123Abnormal hair whorl (HP:0010721)1.87433834
124Acute encephalopathy (HP:0006846)1.87277357
125Hyperthyroidism (HP:0000836)1.86613460
126Sensorimotor neuropathy (HP:0007141)1.86481779
127Impaired vibratory sensation (HP:0002495)1.86151438
128Thickened helices (HP:0000391)1.86012991
129Papilledema (HP:0001085)1.85763764
130Ketoacidosis (HP:0001993)1.85724018
131Agitation (HP:0000713)1.84352979
132Exotropia (HP:0000577)1.84066353
133Tongue fasciculations (HP:0001308)1.82652601
134Iris hypopigmentation (HP:0007730)1.82131750
135Specific learning disability (HP:0001328)1.81111550
136Abnormal neuron morphology (HP:0012757)1.80535357
137Abnormality of the motor neurons (HP:0002450)1.80535357
138Sensory axonal neuropathy (HP:0003390)1.77884687
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77550260
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77550260
141Failure to thrive in infancy (HP:0001531)1.76886042
142Fair hair (HP:0002286)1.76682865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.96278729
2EPHA43.79925841
3MAP3K123.31309678
4FRK3.29666790
5RIPK43.22446840
6MAP3K43.22446836
7MAP3K93.21785658
8TRIM283.12305332
9CASK3.11461581
10PNCK3.08309093
11MAP2K72.82609870
12MINK12.42983524
13PLK22.39657317
14MARK12.18508428
15ERBB32.16374717
16MAP2K42.14481211
17GRK51.92970978
18ARAF1.89742053
19OXSR11.88375358
20NTRK11.79991105
21KSR21.72997923
22PINK11.72737225
23DAPK21.63185440
24CDK191.58721527
25FGR1.52689189
26PAK61.50973422
27NTRK21.49261985
28CSNK1G11.46106198
29CSNK1A1L1.44160576
30BMPR21.42265974
31MAP4K21.40552966
32ACVR1B1.38464562
33STK391.35587846
34KSR11.34438417
35DAPK11.34291727
36FES1.33856671
37NME11.32994076
38CDK51.32977611
39PTK2B1.32625045
40MAP3K131.29776505
41TNIK1.29577626
42CAMK2A1.26384658
43FGFR21.19405288
44PRKCG1.17707846
45CAMK2B1.13647180
46EPHA31.03823970
47GRK71.02341272
48SIK21.00823740
49MAP3K20.97964330
50MAPK130.97254119
51YES10.97128692
52LMTK20.95717820
53CAMKK20.93701703
54PRPF4B0.93365122
55CSNK1G20.90819476
56EIF2AK30.88562282
57BMPR1B0.87800959
58WNK40.87598089
59PRKCE0.84630501
60CAMKK10.84259740
61BCR0.84031062
62CDK140.83744756
63UHMK10.82048765
64CAMK2D0.81606685
65GRK60.81433370
66STK38L0.80671218
67WNK30.80437000
68CDK180.77840958
69RAF10.76505165
70MAPKAPK50.74873528
71CDK150.74420710
72SGK2230.74053334
73SGK4940.74053334
74DYRK1A0.69424954
75FER0.67756974
76SGK30.66842363
77PAK30.65940806
78ROCK20.65451243
79LATS20.64700477
80FGFR30.64522919
81DYRK20.63834895
82MAP3K60.63703225
83STK240.63395313
84CDK11A0.62131269
85EIF2AK10.61837235
86MAP3K50.61806340
87AKT30.61357166
88SGK10.60494679
89RET0.59338341
90STK380.59187149
91CAMK2G0.57916685
92NEK60.57907851
93CAMK1G0.56413692
94RPS6KB10.54059468
95ADRBK10.53398607
96ADRBK20.53239493
97PLK30.53188593
98TYRO30.53127254
99CSNK1G30.51960128
100STK110.50245735
101TAF10.48895257
102MAP3K10.48772782
103PDPK10.47461662
104PDK30.46608012
105PDK40.46608012
106SCYL20.46426958
107FYN0.46298446
108PRKACB0.45933601
109CSNK1D0.45444666
110MAP2K10.45315255
111CAMK10.45195867
112BRAF0.44777933
113PKN10.44568664
114WNK10.44353395
115MOS0.44254999
116CCNB10.42469526
117MUSK0.41809312
118CSNK1A10.41032710
119SGK20.40945262
120PDK10.38566367
121PHKG10.37607377
122PHKG20.37607377
123TAOK10.37504491
124PRKCZ0.36173205
125PRKG20.36018750
126DYRK30.35362085
127TRPM70.34281044
128LIMK10.33539602
129TSSK60.32733703
130PDK20.32639491
131* PRKACA0.32509152
132ALK0.32459317
133PRKCH0.32358559
134SIK30.32123630
135TGFBR20.30300699
136PRKG10.29878926
137PRKAA10.28634246

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.10771947
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.42576770
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84407405
4* Collecting duct acid secretion_Homo sapiens_hsa049662.81060570
5Long-term potentiation_Homo sapiens_hsa047202.62318325
6GABAergic synapse_Homo sapiens_hsa047272.61674406
7Amphetamine addiction_Homo sapiens_hsa050312.39046632
8Morphine addiction_Homo sapiens_hsa050322.35111633
9Glutamatergic synapse_Homo sapiens_hsa047242.34898094
10Circadian entrainment_Homo sapiens_hsa047132.33518015
11Olfactory transduction_Homo sapiens_hsa047402.19953686
12Vitamin B6 metabolism_Homo sapiens_hsa007502.19061468
13* Oxidative phosphorylation_Homo sapiens_hsa001902.16720711
14Dopaminergic synapse_Homo sapiens_hsa047282.08773039
15Salivary secretion_Homo sapiens_hsa049702.02718819
16Serotonergic synapse_Homo sapiens_hsa047261.97932503
17Taste transduction_Homo sapiens_hsa047421.94647787
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92280830
19Long-term depression_Homo sapiens_hsa047301.89590916
20Renin secretion_Homo sapiens_hsa049241.84682055
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.81967740
22* Vibrio cholerae infection_Homo sapiens_hsa051101.72220679
23Gastric acid secretion_Homo sapiens_hsa049711.69229815
24Protein export_Homo sapiens_hsa030601.68742978
25Alzheimers disease_Homo sapiens_hsa050101.67469866
26Cholinergic synapse_Homo sapiens_hsa047251.56213757
27Insulin secretion_Homo sapiens_hsa049111.55043839
28Parkinsons disease_Homo sapiens_hsa050121.52461344
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.49429690
30Calcium signaling pathway_Homo sapiens_hsa040201.48825853
31Cocaine addiction_Homo sapiens_hsa050301.48062249
32Oxytocin signaling pathway_Homo sapiens_hsa049211.41567301
33Sulfur metabolism_Homo sapiens_hsa009201.37725987
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35293938
35Steroid biosynthesis_Homo sapiens_hsa001001.35160505
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33618632
37Regulation of autophagy_Homo sapiens_hsa041401.33094353
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32370856
39* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31464386
40Cardiac muscle contraction_Homo sapiens_hsa042601.29543145
41GnRH signaling pathway_Homo sapiens_hsa049121.27219207
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25486951
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24975107
44Phototransduction_Homo sapiens_hsa047441.20217671
45Gap junction_Homo sapiens_hsa045401.18389654
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13452050
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12861103
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08659803
49Axon guidance_Homo sapiens_hsa043601.05196815
50* Rheumatoid arthritis_Homo sapiens_hsa053231.02529587
51Huntingtons disease_Homo sapiens_hsa050161.01612339
52Estrogen signaling pathway_Homo sapiens_hsa049150.98292909
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97093299
54cAMP signaling pathway_Homo sapiens_hsa040240.97054505
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90754063
56Fatty acid elongation_Homo sapiens_hsa000620.89839368
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89658837
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87637288
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.85581121
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.84051377
61Melanogenesis_Homo sapiens_hsa049160.83854095
62Glioma_Homo sapiens_hsa052140.83836198
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83103459
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82496512
65ErbB signaling pathway_Homo sapiens_hsa040120.77957669
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77357670
67* Phagosome_Homo sapiens_hsa041450.77035273
68Circadian rhythm_Homo sapiens_hsa047100.76737304
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75784191
70Pancreatic secretion_Homo sapiens_hsa049720.74261090
71Type II diabetes mellitus_Homo sapiens_hsa049300.73295695
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69938266
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68364639
74Dorso-ventral axis formation_Homo sapiens_hsa043200.68296924
75beta-Alanine metabolism_Homo sapiens_hsa004100.67470111
76Thyroid hormone synthesis_Homo sapiens_hsa049180.67001115
77Type I diabetes mellitus_Homo sapiens_hsa049400.63836856
78Other glycan degradation_Homo sapiens_hsa005110.63782654
79African trypanosomiasis_Homo sapiens_hsa051430.62901131
80Oocyte meiosis_Homo sapiens_hsa041140.62424213
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61312783
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60952394
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59599846
84Legionellosis_Homo sapiens_hsa051340.59313181
85Choline metabolism in cancer_Homo sapiens_hsa052310.59191271
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.58133624
87mTOR signaling pathway_Homo sapiens_hsa041500.56027033
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.54328189
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52681025
90MAPK signaling pathway_Homo sapiens_hsa040100.52027473
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50298133
92Ras signaling pathway_Homo sapiens_hsa040140.49185903
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46844706
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46250281
95VEGF signaling pathway_Homo sapiens_hsa043700.45252101
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45070048
97Propanoate metabolism_Homo sapiens_hsa006400.44565366
98Fatty acid metabolism_Homo sapiens_hsa012120.43571921
99Lysosome_Homo sapiens_hsa041420.43257236
100Inositol phosphate metabolism_Homo sapiens_hsa005620.43159069
101Prion diseases_Homo sapiens_hsa050200.41166641
102Dilated cardiomyopathy_Homo sapiens_hsa054140.40745887
103Fatty acid biosynthesis_Homo sapiens_hsa000610.40697388
104Alcoholism_Homo sapiens_hsa050340.38213999
105Renal cell carcinoma_Homo sapiens_hsa052110.37857338
106Mineral absorption_Homo sapiens_hsa049780.37020488
107Glucagon signaling pathway_Homo sapiens_hsa049220.37020377
108Peroxisome_Homo sapiens_hsa041460.36941909
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36125754
110Butanoate metabolism_Homo sapiens_hsa006500.35970255
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35816010
112Rap1 signaling pathway_Homo sapiens_hsa040150.34809262
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33349334
114Bile secretion_Homo sapiens_hsa049760.33305888
115Endocytosis_Homo sapiens_hsa041440.31383539
116Ether lipid metabolism_Homo sapiens_hsa005650.30901086
117Selenocompound metabolism_Homo sapiens_hsa004500.28557612
118Tuberculosis_Homo sapiens_hsa051520.28383300
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28297935
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.28158860
121Sphingolipid metabolism_Homo sapiens_hsa006000.21498615
122Ovarian steroidogenesis_Homo sapiens_hsa049130.19625682
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19454922
124Salmonella infection_Homo sapiens_hsa051320.18507574
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17717045
126Wnt signaling pathway_Homo sapiens_hsa043100.17192409
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16502699

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