ATP6V1B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)6.91970747
2aminoglycoside antibiotic metabolic process (GO:0030647)6.45275425
3type B pancreatic cell proliferation (GO:0044342)6.04864638
4urate metabolic process (GO:0046415)6.03366164
5drug transmembrane transport (GO:0006855)5.93313486
6one-carbon compound transport (GO:0019755)5.83916657
7hemidesmosome assembly (GO:0031581)5.78363181
8renal absorption (GO:0070293)5.45720100
9drug transport (GO:0015893)5.14212673
10phosphate ion transport (GO:0006817)5.08675473
11* excretion (GO:0007588)5.05007305
12organic cation transport (GO:0015695)4.95788885
13semaphorin-plexin signaling pathway (GO:0071526)4.94068491
14establishment of apical/basal cell polarity (GO:0035089)4.82578173
15bone remodeling (GO:0046849)4.79092431
16planar cell polarity pathway involved in neural tube closure (GO:0090179)4.78639682
17lysine metabolic process (GO:0006553)4.72764440
18lysine catabolic process (GO:0006554)4.72764440
19growth hormone receptor signaling pathway (GO:0060396)4.70208304
20positive regulation of protein kinase C signaling (GO:0090037)4.63651091
21lung-associated mesenchyme development (GO:0060484)4.56881040
22regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.52277400
23xenobiotic catabolic process (GO:0042178)4.47913071
24paraxial mesoderm development (GO:0048339)4.37182203
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.35973560
26dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.34968340
27toxin transport (GO:1901998)4.28928728
28notochord development (GO:0030903)4.27233979
29quaternary ammonium group transport (GO:0015697)4.23553963
30response to nitrosative stress (GO:0051409)4.21154298
31phosphate ion transmembrane transport (GO:0035435)4.20771387
32positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.15475594
334-hydroxyproline metabolic process (GO:0019471)4.10818544
34response to mercury ion (GO:0046689)4.10621520
35negative regulation of T cell differentiation in thymus (GO:0033085)4.08155691
36cellular response to growth hormone stimulus (GO:0071378)4.02567121
37regulation of water loss via skin (GO:0033561)3.97162142
38tricarboxylic acid metabolic process (GO:0072350)3.89375116
39intestinal epithelial cell development (GO:0060576)3.89071745
40hippo signaling (GO:0035329)3.88829921
41establishment or maintenance of monopolar cell polarity (GO:0061339)3.87980058
42establishment of monopolar cell polarity (GO:0061162)3.87980058
43negative regulation of smooth muscle cell migration (GO:0014912)3.84287615
44glucuronate metabolic process (GO:0019585)3.80296734
45uronic acid metabolic process (GO:0006063)3.80296734
46establishment of skin barrier (GO:0061436)3.74384599
47drug catabolic process (GO:0042737)3.74069037
48bone trabecula formation (GO:0060346)3.72175210
49exogenous drug catabolic process (GO:0042738)3.67967416
50polarized epithelial cell differentiation (GO:0030859)3.67736431
51glyoxylate metabolic process (GO:0046487)3.67127293
52Notch signaling involved in heart development (GO:0061314)3.66599348
53response to growth hormone (GO:0060416)3.64180806
54non-canonical Wnt signaling pathway (GO:0035567)3.60542599
55phosphate ion homeostasis (GO:0055062)3.58927991
56trivalent inorganic anion homeostasis (GO:0072506)3.58927991
57ear development (GO:0043583)3.56996341
58exocrine pancreas development (GO:0031017)3.56902435
59cranial suture morphogenesis (GO:0060363)3.56842896
60negative regulation of fatty acid transport (GO:2000192)3.52139474
61tooth mineralization (GO:0034505)3.51801418
62COPI coating of Golgi vesicle (GO:0048205)3.49008615
63Golgi transport vesicle coating (GO:0048200)3.49008615
64regulation of cell proliferation involved in kidney development (GO:1901722)3.46659157
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.45679183
66regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.44047492
67branching involved in mammary gland duct morphogenesis (GO:0060444)3.44037644
68cell-cell junction maintenance (GO:0045217)3.43690427
69cellular response to vitamin D (GO:0071305)3.42060732
70regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.36025015
71short-chain fatty acid metabolic process (GO:0046459)3.35528342
72negative regulation of cell fate specification (GO:0009996)3.34269894
73Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.34162160
74polyol transport (GO:0015791)3.33552335
75calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.33114670
76carnitine transport (GO:0015879)3.31895968
77amino-acid betaine transport (GO:0015838)3.31895968
78cysteine metabolic process (GO:0006534)3.31582502
79regulation of cholesterol biosynthetic process (GO:0045540)3.30982681
80vitamin transmembrane transport (GO:0035461)3.30653807
81desmosome organization (GO:0002934)3.30617508
82cellular glucuronidation (GO:0052695)3.28770915
83segment specification (GO:0007379)3.27946559
84metanephric tubule development (GO:0072170)3.25594654
85metanephric nephron tubule development (GO:0072234)3.25594654
86negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.25426737
87trophectodermal cell differentiation (GO:0001829)3.21477741
88keratinocyte development (GO:0003334)3.19824039
89gas transport (GO:0015669)3.18415039
90valine metabolic process (GO:0006573)3.18079370
91multicellular organismal water homeostasis (GO:0050891)3.15773419
92collecting duct development (GO:0072044)3.15220565
93cornea development in camera-type eye (GO:0061303)3.14942248
94regulation of establishment of planar polarity (GO:0090175)3.14473108
95regulation of cell fate specification (GO:0042659)3.13526945
96nephron tubule development (GO:0072080)3.12357535
97modified amino acid transport (GO:0072337)3.12202412
98embryonic process involved in female pregnancy (GO:0060136)3.11334692
99asymmetric protein localization (GO:0008105)3.10553442
100positive regulation of hormone metabolic process (GO:0032352)3.10411669
101glutathione derivative metabolic process (GO:1901685)3.09053463
102glutathione derivative biosynthetic process (GO:1901687)3.09053463
103diterpenoid biosynthetic process (GO:0016102)3.07038893
104branching involved in salivary gland morphogenesis (GO:0060445)3.05687725
105apical protein localization (GO:0045176)3.05649830
106cell junction maintenance (GO:0034331)3.05024157
107metanephric nephron epithelium development (GO:0072243)3.04115179
108peptide catabolic process (GO:0043171)3.02012670
109lung epithelium development (GO:0060428)3.01633701
110branched-chain amino acid metabolic process (GO:0009081)2.99017074
111outflow tract septum morphogenesis (GO:0003148)2.98835298
112tight junction assembly (GO:0070830)2.98202266
113benzene-containing compound metabolic process (GO:0042537)2.97575287
114hair cycle (GO:0042633)2.96217940
115molting cycle (GO:0042303)2.96217940
116aspartate family amino acid catabolic process (GO:0009068)2.96175731
117nephron tubule morphogenesis (GO:0072078)2.96058805
118nephron epithelium morphogenesis (GO:0072088)2.96058805
119regulation of G0 to G1 transition (GO:0070316)2.94785918
120activation of Rac GTPase activity (GO:0032863)2.94473922
121atrioventricular valve morphogenesis (GO:0003181)2.93070256
122regulation of ruffle assembly (GO:1900027)2.92108296
123regulation of transforming growth factor beta2 production (GO:0032909)2.92055079
124convergent extension (GO:0060026)2.91735659
125negative regulation of stem cell proliferation (GO:2000647)2.90947642
126iron ion import (GO:0097286)2.90896443
127urogenital system development (GO:0001655)2.90471640
128positive regulation of keratinocyte differentiation (GO:0045618)2.90408303
129nonribosomal peptide biosynthetic process (GO:0019184)2.88949785
130L-ascorbic acid metabolic process (GO:0019852)2.88658556
131cellular response to vitamin (GO:0071295)2.87403906
132apoptotic process involved in morphogenesis (GO:0060561)2.86022542
133establishment or maintenance of apical/basal cell polarity (GO:0035088)2.85625661
134establishment or maintenance of bipolar cell polarity (GO:0061245)2.85625661
135auditory receptor cell stereocilium organization (GO:0060088)2.85105686
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.84586817
137epithelial cell-cell adhesion (GO:0090136)2.84030299
138camera-type eye morphogenesis (GO:0048593)2.82734356
139regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.82280248
140mammary gland epithelial cell proliferation (GO:0033598)2.82150674
141peptidyl-proline hydroxylation (GO:0019511)2.81744582
142acetyl-CoA metabolic process (GO:0006084)2.80149276
143hypotonic response (GO:0006971)2.80075793
144basement membrane organization (GO:0071711)2.79780334
145regulation of clathrin-mediated endocytosis (GO:2000369)2.79773694
146bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79364179
147adherens junction assembly (GO:0034333)2.79073661
148regulation of hippo signaling (GO:0035330)2.78947794
149negative regulation of cell fate commitment (GO:0010454)2.78083126
150positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.77922582
151cardiac right ventricle morphogenesis (GO:0003215)2.77794031
152norepinephrine metabolic process (GO:0042415)2.77789253
153cell-cell junction assembly (GO:0007043)2.77113535
154cell migration in hindbrain (GO:0021535)2.75579094
155sulfur amino acid catabolic process (GO:0000098)2.74959075
156establishment of tissue polarity (GO:0007164)2.74717961
157establishment of planar polarity (GO:0001736)2.74717961
158fatty acid beta-oxidation (GO:0006635)2.74597675
159ethanol oxidation (GO:0006069)2.74420403
160maternal placenta development (GO:0001893)2.74256023
161cellular zinc ion homeostasis (GO:0006882)2.74074587
162cytoskeletal anchoring at plasma membrane (GO:0007016)2.73574785
163vitamin D metabolic process (GO:0042359)2.72913011
164regulation of cholesterol metabolic process (GO:0090181)2.72686904
165response to food (GO:0032094)2.72321217
166glutathione metabolic process (GO:0006749)2.71754931
167biotin metabolic process (GO:0006768)2.71158093
168metanephric epithelium development (GO:0072207)2.70517280
169RNA localization (GO:0006403)2.70220876
170nephron tubule formation (GO:0072079)2.70021186
171negative regulation of cartilage development (GO:0061037)2.69757570
172regulation of apoptotic process involved in morphogenesis (GO:1902337)2.69198224
173morphogenesis of embryonic epithelium (GO:0016331)2.68670607
174renal tubule development (GO:0061326)2.68440828
175sodium-independent organic anion transport (GO:0043252)2.68186937
176positive regulation of odontogenesis (GO:0042482)2.67306127
177trophoblast giant cell differentiation (GO:0060707)2.67219358
178fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.67104288
179erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.65780504
180L-phenylalanine metabolic process (GO:0006558)2.65780504
181negative regulation of keratinocyte proliferation (GO:0010839)2.65014331
182regulation of keratinocyte differentiation (GO:0045616)2.64865473
183regulation of mammary gland epithelial cell proliferation (GO:0033599)2.64759058
184homocysteine metabolic process (GO:0050667)2.64392852
185amino-acid betaine metabolic process (GO:0006577)2.63687126
186hair follicle development (GO:0001942)2.63407488
187response to vitamin D (GO:0033280)2.62642843
188interferon-gamma secretion (GO:0072643)2.61391555
189positive regulation of epidermis development (GO:0045684)2.61291222
190negative regulation of cell size (GO:0045792)2.58208093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.80731705
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.54263531
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.98838134
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.47803652
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.10857231
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.97164438
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97016624
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.56991898
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.33427485
10CLOCK_20551151_ChIP-Seq_293T_Human2.21072802
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13905038
12AHR_22903824_ChIP-Seq_MCF-7_Human2.13484792
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12922611
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12891707
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08330080
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07816214
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.06495608
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.98502722
19LXR_22158963_ChIP-Seq_LIVER_Mouse1.96780946
20* ZNF263_19887448_ChIP-Seq_K562_Human1.92809304
21SOX9_24532713_ChIP-Seq_HFSC_Mouse1.91207554
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89556406
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88970302
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83111366
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79220875
26RACK7_27058665_Chip-Seq_MCF-7_Human1.77650947
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75261112
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74153186
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71881695
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.69902840
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69153455
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68153012
33SMC4_20622854_ChIP-Seq_HELA_Human1.66714407
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62747457
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62270867
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.59737781
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.59661944
38P68_20966046_ChIP-Seq_HELA_Human1.59080812
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56935759
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.56345173
41SOX2_20726797_ChIP-Seq_SW620_Human1.54169937
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53783701
43TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52584621
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48520063
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47544864
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44962704
47SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.44677564
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42980888
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42046574
50* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41609319
51* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41128744
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39056343
53CREB1_26743006_Chip-Seq_LNCaP_Human1.38870839
54CTCF_27219007_Chip-Seq_Bcells_Human1.37878377
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36530979
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35398296
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34055675
58AR_21572438_ChIP-Seq_LNCaP_Human1.33178923
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.31534900
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31458334
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30934792
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30609326
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30131369
64GATA4_25053715_ChIP-Seq_YYC3_Human1.27252952
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.26582129
66CJUN_26792858_Chip-Seq_BT549_Human1.25979078
67TP63_22573176_ChIP-Seq_HFKS_Human1.25760461
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.24625771
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.24549200
70TCF7_22412390_ChIP-Seq_EML_Mouse1.24139047
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.23093478
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22078746
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21980407
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21723560
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21569461
76GATA6_25053715_ChIP-Seq_YYC3_Human1.20111919
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17705114
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17043241
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16634973
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16153002
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16153002
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15503609
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.14274026
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.14274026
85KLF5_25053715_ChIP-Seq_YYC3_Human1.13843664
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13487240
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12765903
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12643292
89TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12622347
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11422600
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09800860
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.09752493
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09480684
94KDM2B_26808549_Chip-Seq_DND41_Human1.09148249
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08891152
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08216873
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.08092354
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07325281
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07221816
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06519120
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06142504
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05383534
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.04984037
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04674306
105ELF5_23300383_ChIP-Seq_T47D_Human1.03335978
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03164324
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03164324
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03164324
109BCOR_27268052_Chip-Seq_Bcells_Human1.01903972
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01415991
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00981023
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00345304
113TP63_23658742_ChIP-Seq_EP156T_Human0.98334174
114RARB_24833708_ChIP-Seq_LIVER_Mouse0.98242628
115TP53_22127205_ChIP-Seq_IMR90_Human0.98128353
116VDR_24787735_ChIP-Seq_THP-1_Human0.97903850
117VDR_21846776_ChIP-Seq_THP-1_Human0.97411393
118* LXR_22292898_ChIP-Seq_THP-1_Human0.97376842
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96824706
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96648038
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96537272
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.96503979
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96239893
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95236641
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95004946
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94798298
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94500214
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94295543
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94286523
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.93354276
131KDM2B_26808549_Chip-Seq_K562_Human0.93244913
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92282803
133TP53_18474530_ChIP-ChIP_U2OS_Human0.90612512
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90154039
135ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88813867
136ATF3_27146783_Chip-Seq_COLON_Human0.88393811
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87484855
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87484855
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86780696
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85312411
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84838824
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83118075
143CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83007977
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.82496247
145AR_21909140_ChIP-Seq_LNCAP_Human0.81416118
146EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81390583
147RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81390583
148RXR_22108803_ChIP-Seq_LS180_Human0.81242833
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.80327241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.84514174
2MP0004043_abnormal_pH_regulation4.15185447
3MP0005360_urolithiasis3.88788576
4MP0004019_abnormal_vitamin_homeostasis3.53887699
5MP0002254_reproductive_system_inflammat3.45598763
6MP0003878_abnormal_ear_physiology3.43662286
7MP0005377_hearing/vestibular/ear_phenot3.43662286
8MP0004885_abnormal_endolymph3.25528062
9MP0003195_calcinosis3.10192725
10MP0000383_abnormal_hair_follicle3.05400130
11MP0003300_gastrointestinal_ulcer2.99624667
12MP0001881_abnormal_mammary_gland2.85615118
13MP0009643_abnormal_urine_homeostasis2.62652704
14MP0008875_abnormal_xenobiotic_pharmacok2.54260230
15MP0001765_abnormal_ion_homeostasis2.51888527
16MP0001849_ear_inflammation2.36711726
17MP0005332_abnormal_amino_acid2.36646000
18MP0003566_abnormal_cell_adhesion2.15784627
19MP0000647_abnormal_sebaceous_gland2.15239199
20MP0002136_abnormal_kidney_physiology2.05743720
21MP0004264_abnormal_extraembryonic_tissu1.90881298
22MP0000762_abnormal_tongue_morphology1.88482885
23MP0005499_abnormal_olfactory_system1.82796551
24MP0005394_taste/olfaction_phenotype1.82796551
25MP0002139_abnormal_hepatobiliary_system1.82571390
26MP0005636_abnormal_mineral_homeostasis1.81390519
27MP0001756_abnormal_urination1.79197382
28MP0002098_abnormal_vibrissa_morphology1.77637074
29MP0004272_abnormal_basement_membrane1.75513758
30MP0000566_synostosis1.71558999
31MP0001958_emphysema1.69448318
32MP0002796_impaired_skin_barrier1.68607850
33MP0008789_abnormal_olfactory_epithelium1.65975994
34MP0003705_abnormal_hypodermis_morpholog1.64473269
35MP0003941_abnormal_skin_development1.64119741
36MP0002249_abnormal_larynx_morphology1.64101103
37MP0004084_abnormal_cardiac_muscle1.51279338
38MP0005451_abnormal_body_composition1.49467058
39MP0002138_abnormal_hepatobiliary_system1.48268629
40MP0000627_abnormal_mammary_gland1.46913866
41MP0005503_abnormal_tendon_morphology1.46648983
42MP0005058_abnormal_lysosome_morphology1.45730479
43MP0002896_abnormal_bone_mineralization1.45398061
44MP0003453_abnormal_keratinocyte_physiol1.45324990
45MP0005409_darkened_coat_color1.45198687
46MP0008961_abnormal_basal_metabolism1.42264380
47MP0004782_abnormal_surfactant_physiolog1.38295790
48MP0000579_abnormal_nail_morphology1.36947272
49MP0005248_abnormal_Harderian_gland1.34807085
50MP0002168_other_aberrant_phenotype1.34080205
51MP0003879_abnormal_hair_cell1.34076181
52MP0005408_hypopigmentation1.33379193
53MP0002282_abnormal_trachea_morphology1.31220652
54MP0010678_abnormal_skin_adnexa1.30337123
55MP0009780_abnormal_chondrocyte_physiolo1.29215749
56MP0000427_abnormal_hair_cycle1.26566190
57MP0003186_abnormal_redox_activity1.25534720
58MP0008260_abnormal_autophagy1.22030177
59MP0000538_abnormal_urinary_bladder1.21673741
60MP0000377_abnormal_hair_follicle1.21123064
61MP0002060_abnormal_skin_morphology1.20776053
62MP0003045_fibrosis1.17258645
63MP0000534_abnormal_ureter_morphology1.14363566
64MP0002877_abnormal_melanocyte_morpholog1.12792681
65MP0002697_abnormal_eye_size1.12516009
66MP0000750_abnormal_muscle_regeneration1.12271754
67MP0001270_distended_abdomen1.10572300
68MP0005501_abnormal_skin_physiology1.10184014
69MP0004185_abnormal_adipocyte_glucose1.09662233
70MP0005083_abnormal_biliary_tract1.08428805
71MP0000467_abnormal_esophagus_morphology1.07472400
72MP0001485_abnormal_pinna_reflex1.07174797
73MP0002909_abnormal_adrenal_gland1.05030695
74MP0005275_abnormal_skin_tensile1.04345290
75MP0000858_altered_metastatic_potential1.03466850
76MP0005666_abnormal_adipose_tissue1.01856164
77MP0005365_abnormal_bile_salt1.01448515
78MP0005085_abnormal_gallbladder_physiolo1.01351147
79MP0000537_abnormal_urethra_morphology0.99672976
80MP0002233_abnormal_nose_morphology0.98616028
81MP0010352_gastrointestinal_tract_polyps0.92323488
82MP0005375_adipose_tissue_phenotype0.91347076
83MP0005257_abnormal_intraocular_pressure0.91067719
84MP0001216_abnormal_epidermal_layer0.91006017
85MP0000367_abnormal_coat/_hair0.90802783
86MP0009931_abnormal_skin_appearance0.90550696
87MP0008872_abnormal_physiological_respon0.90071320
88MP0002135_abnormal_kidney_morphology0.88195862
89MP0003252_abnormal_bile_duct0.88149690
90MP0010030_abnormal_orbit_morphology0.87094325
91MP0004858_abnormal_nervous_system0.86689498
92MP0002751_abnormal_autonomic_nervous0.85686818
93MP0001177_atelectasis0.82342228
94MP0003942_abnormal_urinary_system0.82071071
95MP0005670_abnormal_white_adipose0.81598879
96MP0001348_abnormal_lacrimal_gland0.80063368
97MP0003119_abnormal_digestive_system0.78741973
98MP0002116_abnormal_craniofacial_bone0.78513003
99MP0000432_abnormal_head_morphology0.77760411
100MP0002234_abnormal_pharynx_morphology0.76595456
101MP0003183_abnormal_peptide_metabolism0.74875392
102MP0001502_abnormal_circadian_rhythm0.74783041
103MP0003385_abnormal_body_wall0.73359602
104MP0003938_abnormal_ear_development0.72675529
105MP0001346_abnormal_lacrimal_gland0.72560160
106MP0006138_congestive_heart_failure0.71920667
107MP0003806_abnormal_nucleotide_metabolis0.71781990
108MP0005584_abnormal_enzyme/coenzyme_acti0.70786525
109MP0003115_abnormal_respiratory_system0.70714442
110MP0003936_abnormal_reproductive_system0.70332134
111MP0000163_abnormal_cartilage_morphology0.70322889
112MP0004147_increased_porphyrin_level0.69844898
113MP0001340_abnormal_eyelid_morphology0.69706372
114MP0009053_abnormal_anal_canal0.69564343
115MP0009278_abnormal_bone_marrow0.68947849
116MP0003638_abnormal_response/metabolism_0.68926313
117MP0002086_abnormal_extraembryonic_tissu0.68603793
118MP0002998_abnormal_bone_remodeling0.67830535
119MP0000230_abnormal_systemic_arterial0.67561649
120MP0009379_abnormal_foot_pigmentation0.66811332
121MP0000516_abnormal_urinary_system0.66657289
122MP0005367_renal/urinary_system_phenotyp0.66657289
123MP0005023_abnormal_wound_healing0.66106080
124MP0005310_abnormal_salivary_gland0.65998890
125MP0003935_abnormal_craniofacial_develop0.65838351
126MP0010329_abnormal_lipoprotein_level0.64536555
127MP0000678_abnormal_parathyroid_gland0.64468432
128MP0009384_cardiac_valve_regurgitation0.63313100
129MP0010630_abnormal_cardiac_muscle0.62209074
130MP0000003_abnormal_adipose_tissue0.62175552
131MP0003567_abnormal_fetal_cardiomyocyte0.61783198
132MP0000639_abnormal_adrenal_gland0.61708724
133MP0002111_abnormal_tail_morphology0.61042924
134MP0002653_abnormal_ependyma_morphology0.60596215
135MP0000462_abnormal_digestive_system0.60523637
136MP0002085_abnormal_embryonic_tissue0.59997986
137MP0002108_abnormal_muscle_morphology0.59960153
138MP0005076_abnormal_cell_differentiation0.58666119
139MP0001663_abnormal_digestive_system0.58273391
140MP0002932_abnormal_joint_morphology0.58176729
141MP0010771_integument_phenotype0.57617979
142MP0004381_abnormal_hair_follicle0.57542487
143MP0002092_abnormal_eye_morphology0.57541514
144MP0005508_abnormal_skeleton_morphology0.56997615
145MP0005171_absent_coat_pigmentation0.55135068
146MP0005319_abnormal_enzyme/_coenzyme0.54419098
147MP0001730_embryonic_growth_arrest0.53467632
148MP0000477_abnormal_intestine_morphology0.53431448

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.35311852
2Hypokalemic alkalosis (HP:0001949)6.25611970
3Hyperactive renin-angiotensin system (HP:0000841)5.88625700
4Metabolic alkalosis (HP:0200114)5.73583630
5Abnormality of chloride homeostasis (HP:0011422)5.45555955
6Polyuria (HP:0000103)5.26541660
7Hypomagnesemia (HP:0002917)5.17362368
8Abnormality of renal excretion (HP:0011036)5.09095942
9Abnormal urine output (HP:0012590)4.97323000
10Gout (HP:0001997)4.92181935
11Stomach cancer (HP:0012126)4.40749780
12Milia (HP:0001056)4.37786466
13Abnormality of magnesium homeostasis (HP:0004921)4.30070509
14Cervical subluxation (HP:0003308)4.26373571
15Tetany (HP:0001281)4.10611735
16Abnormal drinking behavior (HP:0030082)4.05621669
17Polydipsia (HP:0001959)4.05621669
18Renal salt wasting (HP:0000127)4.01334720
19Abnormality of renin-angiotensin system (HP:0000847)3.96175116
20Hyperaldosteronism (HP:0000859)3.95224157
21Woolly hair (HP:0002224)3.69717146
22Alkalosis (HP:0001948)3.59531565
23Alveolar cell carcinoma (HP:0006519)3.58385134
24Atrophic scars (HP:0001075)3.56213147
25Hypercalciuria (HP:0002150)3.55619449
26Onycholysis (HP:0001806)3.46245754
27Bilateral sensorineural hearing impairment (HP:0008619)3.37100240
28Obstructive sleep apnea (HP:0002870)3.35610813
29Proximal tubulopathy (HP:0000114)3.34388555
30Amelogenesis imperfecta (HP:0000705)3.33981022
31Right ventricular cardiomyopathy (HP:0011663)3.30299836
32Increased purine levels (HP:0004368)3.28824987
33Hyperuricemia (HP:0002149)3.28824987
34Neoplasm of the tracheobronchial system (HP:0100552)3.27550361
35* Renal tubular acidosis (HP:0001947)3.23630678
36Abnormality of purine metabolism (HP:0004352)3.21553633
37Hyperglycinuria (HP:0003108)3.21515683
38Abnormality of cochlea (HP:0000375)3.11089372
39Abnormality of glutamine family amino acid metabolism (HP:0010902)3.10007708
40Ependymoma (HP:0002888)3.06234746
41Hypokalemia (HP:0002900)3.06080307
42Bell-shaped thorax (HP:0001591)3.03483689
43Vascular calcification (HP:0004934)3.01079579
44Asymmetry of the thorax (HP:0001555)3.00246877
45Morphological abnormality of the inner ear (HP:0011390)2.98406154
46High anterior hairline (HP:0009890)2.97972166
47Nephrocalcinosis (HP:0000121)2.90763023
48Tracheal stenosis (HP:0002777)2.88897892
49Dehydration (HP:0001944)2.79233227
50Cardiovascular calcification (HP:0011915)2.78049347
51Aplasia of the musculature (HP:0100854)2.73963147
52Pili torti (HP:0003777)2.72978063
53Abnormality of dental color (HP:0011073)2.72913318
54Fragile nails (HP:0001808)2.70690241
55Abnormality of potassium homeostasis (HP:0011042)2.69604198
56Rickets (HP:0002748)2.62404708
57Potter facies (HP:0002009)2.58067639
58Facial shape deformation (HP:0011334)2.58067639
59Ketoacidosis (HP:0001993)2.57453328
60Severe Myopia (HP:0011003)2.56818578
61Concave nail (HP:0001598)2.55358615
62Generalized aminoaciduria (HP:0002909)2.53787087
63Abnormality of glycine metabolism (HP:0010895)2.50684740
64Abnormality of serine family amino acid metabolism (HP:0010894)2.50684740
65Stridor (HP:0010307)2.49065476
66Pterygium (HP:0001059)2.40562841
67Broad face (HP:0000283)2.38191533
68Shallow orbits (HP:0000586)2.34702710
69Abnormality of the astrocytes (HP:0100707)2.31849808
70Astrocytoma (HP:0009592)2.31849808
71Hypoplasia of dental enamel (HP:0006297)2.30780558
72Abnormal hair laboratory examination (HP:0003328)2.28770268
73Abnormality of permanent molar morphology (HP:0011071)2.28347726
74Abnormality of the dental root (HP:0006486)2.28347726
75Taurodontia (HP:0000679)2.28347726
76Turricephaly (HP:0000262)2.28114844
77Hypoplasia of the iris (HP:0007676)2.27034191
78Abnormality of sodium homeostasis (HP:0010931)2.26049372
79Persistence of primary teeth (HP:0006335)2.25994328
80Glomerulosclerosis (HP:0000096)2.25237365
81Delayed epiphyseal ossification (HP:0002663)2.23835728
82Abnormality of molar (HP:0011077)2.22182363
83Abnormality of molar morphology (HP:0011070)2.22182363
84Bronchomalacia (HP:0002780)2.20505300
85Hydroxyprolinuria (HP:0003080)2.19664326
86Abnormality of proline metabolism (HP:0010907)2.19664326
87Mildly elevated creatine phosphokinase (HP:0008180)2.19347843
88Curly hair (HP:0002212)2.15571488
89J-shaped sella turcica (HP:0002680)2.15205115
90Absent eyebrow (HP:0002223)2.12773818
91Thin bony cortex (HP:0002753)2.12165342
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12031037
93Widely patent fontanelles and sutures (HP:0004492)2.11506929
94Chondrocalcinosis (HP:0000934)2.10994383
95* Nephrolithiasis (HP:0000787)2.10236976
96Lip pit (HP:0100267)2.09115029
97Abnormality of nucleobase metabolism (HP:0010932)2.08025439
98Advanced eruption of teeth (HP:0006288)2.07991353
99Absent eyelashes (HP:0000561)2.07642693
100Aplasia/Hypoplasia of the clavicles (HP:0006710)2.07615881
101Visceral angiomatosis (HP:0100761)2.05756274
102Metaphyseal cupping (HP:0003021)2.05621942
103Abnormality of the salivary glands (HP:0010286)2.05500556
104Glycosuria (HP:0003076)2.04979657
105Abnormality of urine glucose concentration (HP:0011016)2.04979657
106Abnormal urine phosphate concentration (HP:0012599)2.04817527
107Abnormality of the distal phalanges of the toes (HP:0010182)2.04543098
108Enlarged epiphyses (HP:0010580)2.03497222
109Ketosis (HP:0001946)2.03090967
110Acanthosis nigricans (HP:0000956)2.00619180
111Focal segmental glomerulosclerosis (HP:0000097)2.00441408
112Abnormality of renal resorption (HP:0011038)1.99263137
113Abnormality of Sharpey fibers (HP:0100685)1.99121000
114Natal tooth (HP:0000695)1.98803157
115Broad nasal tip (HP:0000455)1.97732986
116Abnormality of the dental pulp (HP:0006479)1.97690074
117Hypophosphatemia (HP:0002148)1.97588182
118Abnormality of the middle phalanges of the toes (HP:0010183)1.97387179
119Abnormality of the lacrimal duct (HP:0011481)1.96305206
120Myelomeningocele (HP:0002475)1.96256412
121Plantar hyperkeratosis (HP:0007556)1.96030481
122Hyperphosphaturia (HP:0003109)1.95962802
123Abnormal vertebral ossification (HP:0100569)1.95839783
124Lymphangioma (HP:0100764)1.95732840
125Cone-rod dystrophy (HP:0000548)1.94868509
126Ankle contracture (HP:0006466)1.93425580
127Sparse lateral eyebrow (HP:0005338)1.91190240
128Glucose intolerance (HP:0000833)1.91129530
129Increased connective tissue (HP:0009025)1.90855645
130Malnutrition (HP:0004395)1.90370988
131Short clavicles (HP:0000894)1.90321735
132Hypoparathyroidism (HP:0000829)1.90301398
133Fragile skin (HP:0001030)1.87982968
134Choanal stenosis (HP:0000452)1.87119884
135Abnormal tarsal ossification (HP:0008369)1.85502000
136Flat acetabular roof (HP:0003180)1.83739414
137Neonatal short-limb short stature (HP:0008921)1.83422221
138Adrenal overactivity (HP:0002717)1.82328975
139Aplasia cutis congenita (HP:0001057)1.82012341
140Hyperparathyroidism (HP:0000843)1.81255269
141Abnormality of the aortic arch (HP:0012303)1.80458499
142Paralysis (HP:0003470)1.79993727
143Congenital ichthyosiform erythroderma (HP:0007431)1.79962204
144Premature rupture of membranes (HP:0001788)1.79832775
145Abnormality of fatty-acid metabolism (HP:0004359)1.79508709
146Hypoplastic ischia (HP:0003175)1.77131220
147Morphological abnormality of the middle ear (HP:0008609)1.77073248
148Abnormality of the pubic bones (HP:0003172)1.75997487
149Hemangiomatosis (HP:0007461)1.75876632
150Hypotrichosis (HP:0001006)1.71636166
151Neonatal death (HP:0003811)1.70754632
152Down-sloping shoulders (HP:0200021)1.69971290
153Ulnar bowing (HP:0003031)1.69352574
154Broad metatarsal (HP:0001783)1.68585587
155Neoplasm of the lung (HP:0100526)1.68025406
156Glioma (HP:0009733)1.67951150
157Bicornuate uterus (HP:0000813)1.66310852
158Septate vagina (HP:0001153)1.66069168
159Aplasia involving bones of the extremities (HP:0009825)1.64148727
160Aplasia involving bones of the upper limbs (HP:0009823)1.64148727
161Aplasia of the phalanges of the hand (HP:0009802)1.64148727
162Abnormal blistering of the skin (HP:0008066)1.63617602
163* Renal tubular dysfunction (HP:0000124)1.62929243
164Alacrima (HP:0000522)1.62434417
165Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.61885682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.57915918
2MATK4.86400015
3SIK14.56833790
4STK394.25341485
5OXSR14.13398844
6EPHA23.56198750
7WNK33.32603876
8EPHA33.07716767
9EPHB13.06052250
10CDK122.37392573
11NME22.30049349
12FER2.15507473
13FGFR41.79512552
14LATS11.79093687
15ICK1.76721889
16STK38L1.74312919
17MAP3K61.72152851
18RIPK11.60943453
19ERBB21.54174295
20WNK11.49172181
21MST41.44716708
22BMX1.39328646
23BCKDK1.33895180
24PDK31.31934776
25PDK41.31934776
26SMG11.31035867
27ERN11.20466434
28FRK1.20348647
29PDK21.19856009
30CAMK1G1.15618055
31STK381.15464645
32PTK61.14769549
33MAP3K21.13854737
34TRIB31.09951111
35PIK3CA1.07519595
36NLK1.07217848
37SGK4941.06744314
38SGK2231.06744314
39LMTK21.03896879
40MAP3K30.98131619
41PTK20.96129146
42PKN20.95906989
43PBK0.93484434
44MUSK0.92193120
45CAMK1D0.91956991
46EIF2AK10.91720550
47IRAK10.88308867
48RPS6KA20.87575987
49LRRK20.87537695
50MAP2K60.82596031
51PAK30.79999886
52SGK30.77895545
53RET0.75892235
54RPS6KL10.74666922
55RPS6KC10.74666922
56PRKD20.73758187
57ILK0.73237176
58MST1R0.73000662
59SGK20.72434333
60RPS6KA40.71468747
61FGFR10.70796616
62TGFBR20.69234597
63PAK40.66995737
64CDK70.66009717
65GSK3A0.64872958
66MAP3K70.64461687
67DAPK20.63609852
68RPS6KA60.61453050
69DYRK1B0.61262800
70FGFR30.60103270
71EPHB20.58390235
72FGFR20.57359705
73PHKG10.57354386
74PHKG20.57354386
75CDC42BPA0.54667979
76STK240.53332597
77AKT30.52887719
78SCYL20.49785926
79HIPK20.49665841
80TAOK10.49519710
81CDK60.48569073
82KDR0.48234042
83NEK10.47787506
84LATS20.47417062
85DAPK10.44459780
86STK30.44226754
87RPS6KB20.43897797
88MAPKAPK30.43831621
89MAPK150.43385738
90CHUK0.43097382
91MAP3K10.42354324
92DAPK30.42021795
93EEF2K0.41220951
94STK100.40847272
95PDGFRB0.40331106
96MET0.38133952
97PRKG20.35846423
98CAMK2G0.35590670
99NME10.35572652
100PRKD30.35370180
101TTN0.35038986
102INSRR0.34829209
103JAK10.34504261
104TNK20.34256484
105DDR20.33632641
106PRKCI0.32504032
107TRPM70.32223024
108PRKCE0.32180634
109AKT20.31448511
110ZAP700.31208982
111TESK10.30084430
112IRAK30.29697890
113MAP2K20.27233590
114EGFR0.27121636
115PDGFRA0.25921379
116PRKD10.25089428
117MAPK10.24889521
118MTOR0.24062118
119MAP2K30.22645463
120NEK60.22612965
121PRKAA10.22460495
122GRK60.21687294
123SGK10.21597587
124JAK20.20773087
125PDPK10.20699536
126CAMK40.19736822
127MAPKAPK20.19707811
128MAP2K10.19700891
129ALK0.19533560
130CSNK1A10.18889821
131ABL20.17942760
132MAPK30.17721776
133INSR0.17057153
134NTRK10.16808406
135MAPK80.16060070
136PRKCZ0.15482700
137AURKB0.15437995
138PRKAA20.15104052
139IGF1R0.15071426
140RPS6KA10.14984978
141SRC0.13917682
142MARK20.13356856
143MAP3K110.11640413
144MAP3K140.11394904
145CSNK1G10.08814571

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.64196211
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.59037159
3Folate biosynthesis_Homo sapiens_hsa007903.39386524
4Notch signaling pathway_Homo sapiens_hsa043302.80507975
5Butanoate metabolism_Homo sapiens_hsa006502.65351320
6Hedgehog signaling pathway_Homo sapiens_hsa043402.49983798
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.48538326
8Propanoate metabolism_Homo sapiens_hsa006402.45406986
9Sulfur metabolism_Homo sapiens_hsa009202.37416605
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.25264703
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20425387
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07079864
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02923966
14Fatty acid degradation_Homo sapiens_hsa000712.00882013
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.99198893
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90268225
17beta-Alanine metabolism_Homo sapiens_hsa004101.90224900
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86854756
19Chemical carcinogenesis_Homo sapiens_hsa052041.83764085
20Pyruvate metabolism_Homo sapiens_hsa006201.81641647
21Glutathione metabolism_Homo sapiens_hsa004801.79657322
22* Collecting duct acid secretion_Homo sapiens_hsa049661.76738824
23Fatty acid metabolism_Homo sapiens_hsa012121.72516942
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65563303
25Thyroid cancer_Homo sapiens_hsa052161.64259484
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.61856366
27Peroxisome_Homo sapiens_hsa041461.61544465
28Bladder cancer_Homo sapiens_hsa052191.53927019
29Protein digestion and absorption_Homo sapiens_hsa049741.52630836
30Adherens junction_Homo sapiens_hsa045201.51502264
31ECM-receptor interaction_Homo sapiens_hsa045121.49319517
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47990505
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47828756
34Ribosome_Homo sapiens_hsa030101.46802960
35Phenylalanine metabolism_Homo sapiens_hsa003601.42808497
36Insulin signaling pathway_Homo sapiens_hsa049101.38461019
37Fatty acid biosynthesis_Homo sapiens_hsa000611.37016808
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35101118
39Tryptophan metabolism_Homo sapiens_hsa003801.31222560
40Axon guidance_Homo sapiens_hsa043601.30247937
41Starch and sucrose metabolism_Homo sapiens_hsa005001.30107580
42Bile secretion_Homo sapiens_hsa049761.23428248
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22263786
44PPAR signaling pathway_Homo sapiens_hsa033201.20880000
45Caffeine metabolism_Homo sapiens_hsa002321.17992371
46Histidine metabolism_Homo sapiens_hsa003401.17348349
47Melanogenesis_Homo sapiens_hsa049161.15798340
48Choline metabolism in cancer_Homo sapiens_hsa052311.14613924
49Mineral absorption_Homo sapiens_hsa049781.13820575
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12290291
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12282326
52Wnt signaling pathway_Homo sapiens_hsa043101.11904901
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11420132
54Pancreatic cancer_Homo sapiens_hsa052121.10642989
55Vitamin digestion and absorption_Homo sapiens_hsa049771.10344596
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09268971
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08788628
58Carbon metabolism_Homo sapiens_hsa012001.08236111
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.06083936
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03643223
61ABC transporters_Homo sapiens_hsa020101.03332253
62Endometrial cancer_Homo sapiens_hsa052131.03101779
63Endocytosis_Homo sapiens_hsa041441.02914138
64Lysine degradation_Homo sapiens_hsa003101.02690346
65Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00709218
66Arginine biosynthesis_Homo sapiens_hsa002200.99795519
67mTOR signaling pathway_Homo sapiens_hsa041500.96671461
68Focal adhesion_Homo sapiens_hsa045100.94672730
69Galactose metabolism_Homo sapiens_hsa000520.94006883
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93789437
71Lysosome_Homo sapiens_hsa041420.93154751
72Amoebiasis_Homo sapiens_hsa051460.90591448
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.89614774
74N-Glycan biosynthesis_Homo sapiens_hsa005100.88752019
75Small cell lung cancer_Homo sapiens_hsa052220.87735781
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85007044
77Sphingolipid metabolism_Homo sapiens_hsa006000.84314421
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81910763
79mRNA surveillance pathway_Homo sapiens_hsa030150.81324167
80Insulin resistance_Homo sapiens_hsa049310.81270209
81Pentose phosphate pathway_Homo sapiens_hsa000300.80430940
82Gastric acid secretion_Homo sapiens_hsa049710.79178827
83Non-small cell lung cancer_Homo sapiens_hsa052230.79149962
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79072952
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78055206
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77911476
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76918589
88VEGF signaling pathway_Homo sapiens_hsa043700.76362880
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74513144
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73980556
91Proteoglycans in cancer_Homo sapiens_hsa052050.72743053
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71942356
93Selenocompound metabolism_Homo sapiens_hsa004500.70031282
94Inositol phosphate metabolism_Homo sapiens_hsa005620.69997997
95Prostate cancer_Homo sapiens_hsa052150.69885458
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.67917319
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.67875761
98* Vibrio cholerae infection_Homo sapiens_hsa051100.67670074
99HIF-1 signaling pathway_Homo sapiens_hsa040660.64009536
100Tight junction_Homo sapiens_hsa045300.63495527
101Ovarian steroidogenesis_Homo sapiens_hsa049130.63371878
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.62901513
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59869359
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59812881
105Arginine and proline metabolism_Homo sapiens_hsa003300.59503958
106Fructose and mannose metabolism_Homo sapiens_hsa000510.59239065
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.56482121
108Fatty acid elongation_Homo sapiens_hsa000620.55604034
109Base excision repair_Homo sapiens_hsa034100.55286027
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54684781
111Glycerolipid metabolism_Homo sapiens_hsa005610.54292175
112Rap1 signaling pathway_Homo sapiens_hsa040150.53491810
113Circadian rhythm_Homo sapiens_hsa047100.51996159
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51364767
115Ras signaling pathway_Homo sapiens_hsa040140.50276186
116Thyroid hormone synthesis_Homo sapiens_hsa049180.50005650
117Hippo signaling pathway_Homo sapiens_hsa043900.49694524
118Toxoplasmosis_Homo sapiens_hsa051450.49678383
119Sulfur relay system_Homo sapiens_hsa041220.49012114
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.47933522
121Biosynthesis of amino acids_Homo sapiens_hsa012300.46494953
122Tyrosine metabolism_Homo sapiens_hsa003500.45239217
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45141482
124Prolactin signaling pathway_Homo sapiens_hsa049170.44562131
125Basal cell carcinoma_Homo sapiens_hsa052170.43585611
126Retinol metabolism_Homo sapiens_hsa008300.43397700
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.42434618
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.39337459
129Acute myeloid leukemia_Homo sapiens_hsa052210.38392996
130FoxO signaling pathway_Homo sapiens_hsa040680.37286501
131Salivary secretion_Homo sapiens_hsa049700.37269782
132* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36904888
133AMPK signaling pathway_Homo sapiens_hsa041520.36115348
134Renin-angiotensin system_Homo sapiens_hsa046140.35102796
135ErbB signaling pathway_Homo sapiens_hsa040120.33242909
136Chronic myeloid leukemia_Homo sapiens_hsa052200.32901795
137Pathways in cancer_Homo sapiens_hsa052000.31076574
138Renal cell carcinoma_Homo sapiens_hsa052110.29392914
139MicroRNAs in cancer_Homo sapiens_hsa052060.28958380
140Other glycan degradation_Homo sapiens_hsa005110.27598164
141Hepatitis C_Homo sapiens_hsa051600.26894091
142* Rheumatoid arthritis_Homo sapiens_hsa053230.26339905
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25132958
144Melanoma_Homo sapiens_hsa052180.23917260

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