ATP6V1B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.26159929
2synaptic vesicle maturation (GO:0016188)6.19685469
3synaptic vesicle exocytosis (GO:0016079)6.06812953
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.76370648
5regulation of synaptic vesicle exocytosis (GO:2000300)5.64406368
6glutamate secretion (GO:0014047)5.43967436
7locomotory exploration behavior (GO:0035641)5.29621257
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.25880078
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10213316
10regulation of synaptic vesicle transport (GO:1902803)4.99871995
11vocalization behavior (GO:0071625)4.80635690
12negative regulation of interleukin-12 production (GO:0032695)4.73695069
13negative regulation of cell killing (GO:0031342)4.72702750
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.72702750
15macrophage activation involved in immune response (GO:0002281)4.71668640
16cellular potassium ion homeostasis (GO:0030007)4.64025349
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.63335489
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.63335489
19modulation by symbiont of host immune response (GO:0052553)4.63335489
20positive regulation by symbiont of host defense response (GO:0052509)4.63335489
21modulation by symbiont of host defense response (GO:0052031)4.63335489
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.63335489
23neurotransmitter secretion (GO:0007269)4.62384587
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.61269443
25response to peptidoglycan (GO:0032494)4.60370174
26regulation of glutamate receptor signaling pathway (GO:1900449)4.47923520
27protein localization to synapse (GO:0035418)4.47120636
28neutrophil activation involved in immune response (GO:0002283)4.46997854
29positive regulation of gamma-delta T cell activation (GO:0046645)4.44590580
30neuronal action potential propagation (GO:0019227)4.25862278
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23688393
32detection of molecule of bacterial origin (GO:0032490)4.17403950
33sodium ion export (GO:0071436)4.12967372
34proline transport (GO:0015824)4.08532137
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.08490761
36exploration behavior (GO:0035640)4.05529958
37regulation of neuronal synaptic plasticity (GO:0048168)4.05185034
38ionotropic glutamate receptor signaling pathway (GO:0035235)4.03689273
39regulation of synapse structural plasticity (GO:0051823)4.01155582
40cellular extravasation (GO:0045123)4.00712067
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.96984498
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91788756
43synaptic vesicle endocytosis (GO:0048488)3.90744551
44layer formation in cerebral cortex (GO:0021819)3.84750888
45detection of other organism (GO:0098543)3.83779402
46neuron cell-cell adhesion (GO:0007158)3.82955498
47neurotransmitter-gated ion channel clustering (GO:0072578)3.82620097
48synaptic transmission, glutamatergic (GO:0035249)3.79542573
49neuron-neuron synaptic transmission (GO:0007270)3.76945364
50neurotransmitter transport (GO:0006836)3.76351895
51activation of protein kinase A activity (GO:0034199)3.74491447
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.72498803
53glutamate receptor signaling pathway (GO:0007215)3.71737121
54positive regulation of synapse maturation (GO:0090129)3.71593477
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70770285
56neuromuscular process controlling posture (GO:0050884)3.66574706
57positive regulation of cellular amide metabolic process (GO:0034250)3.65563109
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.64806482
59macrophage activation (GO:0042116)3.63482015
60long-term memory (GO:0007616)3.59703057
61detection of external biotic stimulus (GO:0098581)3.59148292
62microglial cell activation (GO:0001774)3.58052417
63positive regulation of membrane potential (GO:0045838)3.54802604
64positive regulation of mast cell activation (GO:0033005)3.54732272
65gamma-aminobutyric acid transport (GO:0015812)3.54222401
66regulation of neurotransmitter secretion (GO:0046928)3.52915704
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51927490
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.49686605
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45461752
70long-term synaptic potentiation (GO:0060291)3.44817854
71regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44366240
72regulation of mast cell degranulation (GO:0043304)3.44353732
73regulation of vesicle fusion (GO:0031338)3.43489335
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42480476
75vesicle transport along microtubule (GO:0047496)3.39015612
76cell communication by electrical coupling (GO:0010644)3.38824616
77detection of bacterium (GO:0016045)3.38384414
78granulocyte activation (GO:0036230)3.38333703
79regulation of neurotransmitter levels (GO:0001505)3.38214309
80regulation of interferon-beta biosynthetic process (GO:0045357)3.36385425
81regulation of synaptic plasticity (GO:0048167)3.34888803
82neutrophil mediated immunity (GO:0002446)3.34575609
83regulation of postsynaptic membrane potential (GO:0060078)3.32880421
84myeloid cell activation involved in immune response (GO:0002275)3.32737815
85cerebellar Purkinje cell differentiation (GO:0021702)3.30073906
86positive regulation of mast cell activation involved in immune response (GO:0033008)3.29745004
87positive regulation of mast cell degranulation (GO:0043306)3.29745004
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29600841
89negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29501760
90regulation of neurotransmitter transport (GO:0051588)3.28164576
91neutrophil activation (GO:0042119)3.25370015
92glycine transport (GO:0015816)3.24827227
93response to pheromone (GO:0019236)3.22715678
94respiratory burst (GO:0045730)3.21638745
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20211917
96regulation of mast cell activation involved in immune response (GO:0033006)3.20050018
97regulation of synaptic transmission, glutamatergic (GO:0051966)3.19944707
98immunoglobulin mediated immune response (GO:0016064)3.19525710
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18902234
100regulation of B cell receptor signaling pathway (GO:0050855)3.18769741
101glycosphingolipid catabolic process (GO:0046479)3.18722523
102neuromuscular process controlling balance (GO:0050885)3.18513546
103regulation of leukocyte degranulation (GO:0043300)3.17958118
104antigen processing and presentation of endogenous antigen (GO:0019883)3.17368778
105synaptic vesicle transport (GO:0048489)3.16077417
106establishment of synaptic vesicle localization (GO:0097480)3.16077417
107innervation (GO:0060384)3.14780320
108detection of biotic stimulus (GO:0009595)3.13909385
109cellular response to thyroid hormone stimulus (GO:0097067)3.13885030
110response to histamine (GO:0034776)3.13372189
111membrane depolarization during action potential (GO:0086010)3.12683953
112response to auditory stimulus (GO:0010996)3.11495060
113regulation of regulated secretory pathway (GO:1903305)3.10874424
114mating behavior (GO:0007617)3.10290640
115positive regulation of neurotransmitter transport (GO:0051590)3.10093770
116response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10024115
117response to host immune response (GO:0052572)3.10024115
118potassium ion homeostasis (GO:0055075)3.08848066
119regulation of gamma-delta T cell activation (GO:0046643)3.08742089
120regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08290381
121regulation of mast cell activation (GO:0033003)3.07042418
122amino sugar catabolic process (GO:0046348)3.02051078
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99344546
124* phagosome maturation (GO:0090382)2.98971419
125positive regulation of synaptic transmission (GO:0050806)2.98809007
126antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98469375
127positive regulation of neurotransmitter secretion (GO:0001956)2.97990256
128synaptic transmission (GO:0007268)2.97880019
129regulation of T-helper 2 cell differentiation (GO:0045628)2.97209452
130myeloid leukocyte mediated immunity (GO:0002444)2.97034941
131membrane hyperpolarization (GO:0060081)2.96843749
132prepulse inhibition (GO:0060134)2.96590762
133regulation of voltage-gated calcium channel activity (GO:1901385)2.95251762
134establishment of vesicle localization (GO:0051650)2.95144497
135negative regulation of interleukin-17 production (GO:0032700)2.94424749
136negative regulation of lymphocyte mediated immunity (GO:0002707)2.93934884
137* transferrin transport (GO:0033572)2.92011618
138membrane depolarization (GO:0051899)2.91821260
139positive regulation of leukocyte degranulation (GO:0043302)2.91065933
140germinal center formation (GO:0002467)2.90897497
141interferon-gamma-mediated signaling pathway (GO:0060333)2.90737408
142organelle transport along microtubule (GO:0072384)2.90666572
143regulation of exocytosis (GO:0017157)2.90534056
144cerebellar Purkinje cell layer development (GO:0021680)2.89571351
145regulation of clathrin-mediated endocytosis (GO:2000369)2.89408344
146regulation of synaptic transmission (GO:0050804)2.89382706
147negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89242608
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88667642
149oligosaccharide catabolic process (GO:0009313)2.88367426
150positive regulation of exocytosis (GO:0045921)2.87784869
151regulation of ARF protein signal transduction (GO:0032012)2.87723182
152axon cargo transport (GO:0008088)2.87646712
153synapse assembly (GO:0007416)2.87354154
154regulation of calcium ion-dependent exocytosis (GO:0017158)2.87299186
155neuron recognition (GO:0008038)2.86432885
156striatum development (GO:0021756)2.86104600
157glycolipid catabolic process (GO:0019377)2.85344583
158positive regulation of macrophage cytokine production (GO:0060907)2.85178709
159long term synaptic depression (GO:0060292)2.84993858
160dendritic spine morphogenesis (GO:0060997)2.84892305
161positive regulation of vesicle fusion (GO:0031340)2.84472555
162production of molecular mediator involved in inflammatory response (GO:0002532)2.83237584
163positive regulation of regulated secretory pathway (GO:1903307)2.83042663
164regulation of dendritic spine morphogenesis (GO:0061001)2.82950041
165T-helper 1 type immune response (GO:0042088)2.81412539
166positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80916772
167negative regulation of leukocyte mediated immunity (GO:0002704)2.79951538
168positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.75081708
169regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.72034012
170regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.71795537
171positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.70924812
172neutrophil chemotaxis (GO:0030593)2.70329918
173negative regulation of erythrocyte differentiation (GO:0045647)2.70073648
174positive regulation of toll-like receptor signaling pathway (GO:0034123)2.69999569
175negative regulation of T cell mediated immunity (GO:0002710)2.69758668
176leukocyte aggregation (GO:0070486)2.67473762
177response to muramyl dipeptide (GO:0032495)2.66541722
178regulation of beta-amyloid formation (GO:1902003)2.66199983
179response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64910734
180response to host (GO:0075136)2.64910734
181response to host defenses (GO:0052200)2.64910734
182regulation of cellular amide metabolic process (GO:0034248)2.64030955
183neutrophil migration (GO:1990266)2.63420249
184myeloid leukocyte activation (GO:0002274)2.63377464
185regulation of T cell tolerance induction (GO:0002664)2.60708810
186positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58407981
187regulation of macrophage cytokine production (GO:0010935)2.55905981
188negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.54551447
189defense response to protozoan (GO:0042832)2.53605525
190protein localization to endosome (GO:0036010)2.51449341
191regulation of tolerance induction (GO:0002643)2.51421918
192ceramide catabolic process (GO:0046514)2.51356373
193regulation of amyloid precursor protein catabolic process (GO:1902991)2.49614102
194N-acetylneuraminate metabolic process (GO:0006054)2.49157950
195positive regulation of type 2 immune response (GO:0002830)2.49037365
196type I interferon signaling pathway (GO:0060337)2.47164052
197cellular response to type I interferon (GO:0071357)2.47164052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.24414939
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.67081098
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.66833259
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.60938499
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.72150239
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.55844384
7GBX2_23144817_ChIP-Seq_PC3_Human3.48156009
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10597915
9* REST_21632747_ChIP-Seq_MESCs_Mouse3.10458125
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07880981
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03160648
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99132711
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.94904236
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93310390
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.89037291
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80449895
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75908079
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66552404
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.64630804
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62363350
21DROSHA_22980978_ChIP-Seq_HELA_Human2.59622658
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53598491
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53158688
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51206366
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48735289
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48735289
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.48437741
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47412725
29SPI1_23127762_ChIP-Seq_K562_Human2.42371642
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38936518
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33750571
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30333063
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28911028
34VDR_24787735_ChIP-Seq_THP-1_Human2.28500854
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27315129
36SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17749053
37EZH2_27294783_Chip-Seq_ESCs_Mouse2.14255036
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13872691
39EZH2_27304074_Chip-Seq_ESCs_Mouse2.12489610
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11617453
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07576381
42RNF2_27304074_Chip-Seq_ESCs_Mouse2.02240437
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01146297
44SPI1_23547873_ChIP-Seq_NB4_Human1.98787455
45VDR_24763502_ChIP-Seq_THP-1_Human1.91114387
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.90804202
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90359487
48RUNX_20019798_ChIP-Seq_JUKART_Human1.87504234
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82530833
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79941521
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79445003
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77926588
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74294559
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72082578
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.70276082
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67084032
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66733224
58SMAD4_21799915_ChIP-Seq_A2780_Human1.66622260
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66027556
60SCL_19346495_ChIP-Seq_HPC-7_Human1.65628172
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65185674
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58549683
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58296179
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57285559
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57130942
66AR_21572438_ChIP-Seq_LNCaP_Human1.56748726
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56004399
68* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55513869
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.55266251
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54231024
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53435318
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53312222
73GATA1_22025678_ChIP-Seq_K562_Human1.53116165
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.52641873
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49504494
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47013288
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45708459
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.43974024
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43452924
80PU_27001747_Chip-Seq_BMDM_Mouse1.42981490
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42535347
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.38613199
83TAF15_26573619_Chip-Seq_HEK293_Human1.38214191
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34941163
85VDR_21846776_ChIP-Seq_THP-1_Human1.33662648
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31433530
87AR_25329375_ChIP-Seq_VCAP_Human1.30907070
88ZNF274_21170338_ChIP-Seq_K562_Hela1.29666168
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28984276
90MYB_26560356_Chip-Seq_TH2_Human1.28167428
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27765431
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27184618
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26699066
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26583514
95IGF1R_20145208_ChIP-Seq_DFB_Human1.25717790
96AR_19668381_ChIP-Seq_PC3_Human1.25370974
97P300_19829295_ChIP-Seq_ESCs_Human1.24781345
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.24201824
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23454007
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23157442
101STAT3_23295773_ChIP-Seq_U87_Human1.22781724
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22734130
103MAF_26560356_Chip-Seq_TH1_Human1.22346217
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20616357
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19036701
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.17942435
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16035664
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15829057
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15502315
110GATA1_19941826_ChIP-Seq_K562_Human1.14992871
111KDM2B_26808549_Chip-Seq_DND41_Human1.14902719
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14836604
113KDM2B_26808549_Chip-Seq_K562_Human1.14830984
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14556405
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14538090
116GATA3_27048872_Chip-Seq_THYMUS_Human1.14531551
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.14386547
118TCF7_22412390_ChIP-Seq_EML_Mouse1.13349803
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12988188
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.12490690
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11716719
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11349117
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11015656
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10448249
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10127184
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03984871
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03876555
128SMAD3_21741376_ChIP-Seq_ESCs_Human1.03147102
129TCF4_23295773_ChIP-Seq_U87_Human1.02981467
130* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02449990
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01501348
132PIAS1_25552417_ChIP-Seq_VCAP_Human1.00093377
133GATA3_26560356_Chip-Seq_TH2_Human0.99841916
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99820205
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99810770
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99721980
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98630584
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97554505
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.96819320
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.95292522
141UTX_26944678_Chip-Seq_JUKART_Human0.95182049
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95093834
143TFEB_21752829_ChIP-Seq_HELA_Human0.95047869
144MYB_26560356_Chip-Seq_TH1_Human0.94907291
145* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93849555
146AHR_22903824_ChIP-Seq_MCF-7_Human0.93752811
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93529784
148GATA2_19941826_ChIP-Seq_K562_Human0.92299809
149GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91255599
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91212931
151LXR_22292898_ChIP-Seq_THP-1_Human0.90840413
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89934065
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89811558
154* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89164954
155FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88104728
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.88060707
157RUNX2_22187159_ChIP-Seq_PCA_Human0.87543835
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.87534267
159RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87144863
160GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86448012
161TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85312875
162* SMAD3_21741376_ChIP-Seq_HESCs_Human0.84792058
163RNF2_27304074_Chip-Seq_NSC_Mouse0.84011060
164RXR_22108803_ChIP-Seq_LS180_Human0.83930648
165KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83067521
166TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82291807
167THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81740550
168KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80309436
169TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80183653
170SMRT_27268052_Chip-Seq_Bcells_Human0.79970158
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79659018
172FLI1_21867929_ChIP-Seq_TH2_Mouse0.79443917
173MAF_26560356_Chip-Seq_TH2_Human0.78910104
174NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78028662
175TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78021394
176BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77791255
177FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75602264
178GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75313430
179EGR1_19032775_ChIP-ChIP_M12_Human0.74010254
180KDM2B_26808549_Chip-Seq_JURKAT_Human0.73813913
181PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72347605
182VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.71730498
183RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64276277
184* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.60017505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.22997998
2MP0003880_abnormal_central_pattern4.39820547
3MP0003635_abnormal_synaptic_transmissio4.01329018
4MP0003724_increased_susceptibility_to3.96171494
5MP0004270_analgesia3.55027669
6MP0006082_CNS_inflammation3.39518729
7MP0009046_muscle_twitch3.27151138
8MP0002064_seizures3.21851832
9MP0009745_abnormal_behavioral_response3.21657517
10MP0002063_abnormal_learning/memory/cond3.21035169
11MP0003436_decreased_susceptibility_to3.18133466
12MP0001968_abnormal_touch/_nociception3.04095217
13MP0001835_abnormal_antigen_presentation2.89426516
14MP0002419_abnormal_innate_immunity2.80013141
15MP0002734_abnormal_mechanical_nocicepti2.68747094
16MP0002572_abnormal_emotion/affect_behav2.64535124
17MP0003191_abnormal_cellular_cholesterol2.53063519
18MP0009785_altered_susceptibility_to2.51655770
19MP0002822_catalepsy2.49536985
20MP0002272_abnormal_nervous_system2.48624282
21MP0005671_abnormal_response_to2.45456620
22MP0002735_abnormal_chemical_nociception2.40696338
23MP0002148_abnormal_hypersensitivity_rea2.39585104
24MP0002736_abnormal_nociception_after2.37895717
25MP0005000_abnormal_immune_tolerance2.31920270
26MP0005423_abnormal_somatic_nervous2.31446298
27MP0005025_abnormal_response_to2.30500208
28MP0002909_abnormal_adrenal_gland2.30232562
29MP0003300_gastrointestinal_ulcer2.29897819
30MP0001501_abnormal_sleep_pattern2.26969959
31MP0001486_abnormal_startle_reflex2.23092559
32MP0005387_immune_system_phenotype2.17646465
33MP0001790_abnormal_immune_system2.17646465
34MP0002733_abnormal_thermal_nociception2.13526586
35MP0009840_abnormal_foam_cell2.11452844
36MP0009780_abnormal_chondrocyte_physiolo2.10982179
37MP0004858_abnormal_nervous_system2.06133248
38MP0008260_abnormal_autophagy2.05614097
39MP0001970_abnormal_pain_threshold2.05527934
40MP0001440_abnormal_grooming_behavior2.02088931
41MP0010386_abnormal_urinary_bladder2.01650502
42MP0003329_amyloid_beta_deposits1.98652785
43MP0002067_abnormal_sensory_capabilities1.98536267
44MP0002452_abnormal_antigen_presenting1.95518416
45MP0002723_abnormal_immune_serum1.94294454
46MP0001800_abnormal_humoral_immune1.87458391
47MP0001533_abnormal_skeleton_physiology1.87174425
48MP0008569_lethality_at_weaning1.86428304
49MP0003879_abnormal_hair_cell1.86105063
50MP0000685_abnormal_immune_system1.84275937
51MP0004811_abnormal_neuron_physiology1.80112718
52MP0002420_abnormal_adaptive_immunity1.78132538
53MP0001819_abnormal_immune_cell1.76244892
54MP0000343_altered_response_to1.71505321
55MP0001984_abnormal_olfaction1.69520680
56MP0002184_abnormal_innervation1.69458078
57MP0009764_decreased_sensitivity_to1.65955909
58MP0005451_abnormal_body_composition1.62825071
59MP0003172_abnormal_lysosome_physiology1.62677722
60MP0005386_behavior/neurological_phenoty1.61615594
61MP0004924_abnormal_behavior1.61615594
62MP0002998_abnormal_bone_remodeling1.59977116
63MP0005646_abnormal_pituitary_gland1.59504703
64MP0002557_abnormal_social/conspecific_i1.56836621
65MP0005464_abnormal_platelet_physiology1.55786925
66MP0006276_abnormal_autonomic_nervous1.53211104
67MP0001845_abnormal_inflammatory_respons1.51792497
68MP0009278_abnormal_bone_marrow1.49261700
69MP0003633_abnormal_nervous_system1.48681211
70MP0000955_abnormal_spinal_cord1.46504345
71MP0001502_abnormal_circadian_rhythm1.46478603
72MP0003787_abnormal_imprinting1.42684102
73MP0005551_abnormal_eye_electrophysiolog1.42337299
74MP0000569_abnormal_digit_pigmentation1.42312759
75MP0003183_abnormal_peptide_metabolism1.39631212
76MP0003122_maternal_imprinting1.38789086
77MP0002405_respiratory_system_inflammati1.38157241
78MP0005645_abnormal_hypothalamus_physiol1.38126640
79MP0004947_skin_inflammation1.36869402
80MP0002066_abnormal_motor_capabilities/c1.36654179
81MP0002882_abnormal_neuron_morphology1.36591424
82MP0000013_abnormal_adipose_tissue1.35801442
83MP0005166_decreased_susceptibility_to1.35508059
84MP0002090_abnormal_vision1.32912638
85MP0008469_abnormal_protein_level1.27560135
86MP0004885_abnormal_endolymph1.26819711
87MP0003656_abnormal_erythrocyte_physiolo1.25964102
88MP0000604_amyloidosis1.24866937
89MP0000778_abnormal_nervous_system1.24167132
90MP0000015_abnormal_ear_pigmentation1.23054026
91MP0001545_abnormal_hematopoietic_system1.22100979
92MP0005397_hematopoietic_system_phenotyp1.22100979
93MP0002229_neurodegeneration1.19964691
94MP0003828_pulmonary_edema1.19415992
95MP0000716_abnormal_immune_system1.19087979
96MP0010155_abnormal_intestine_physiology1.18066413
97MP0003631_nervous_system_phenotype1.17196964
98MP0004043_abnormal_pH_regulation1.14394216
99MP0004142_abnormal_muscle_tone1.10322841
100MP0003448_altered_tumor_morphology1.09962931
101MP0003283_abnormal_digestive_organ1.08883393
102MP0008961_abnormal_basal_metabolism1.08560271
103MP0001853_heart_inflammation1.06975218
104MP0003075_altered_response_to1.05466527
105MP0003634_abnormal_glial_cell1.04114596
106MP0002139_abnormal_hepatobiliary_system1.02646774
107MP0003690_abnormal_glial_cell1.01179918
108MP0004883_abnormal_blood_vessel1.01075969
109MP0005535_abnormal_body_temperature1.00788791
110MP0005058_abnormal_lysosome_morphology0.99238974
111MP0001905_abnormal_dopamine_level0.98985811
112MP0002398_abnormal_bone_marrow0.98275151
113MP0002638_abnormal_pupillary_reflex0.97868273
114MP0001529_abnormal_vocalization0.96999140
115MP0002069_abnormal_eating/drinking_beha0.95661505
116MP0004233_abnormal_muscle_weight0.93494607
117MP0005164_abnormal_response_to0.92946360
118MP0000858_altered_metastatic_potential0.92069251
119MP0008004_abnormal_stomach_pH0.91561685
120MP0002152_abnormal_brain_morphology0.91305420
121MP0006072_abnormal_retinal_apoptosis0.89238599
122MP0008872_abnormal_physiological_respon0.87522796
123MP0000689_abnormal_spleen_morphology0.87380967
124MP0003195_calcinosis0.84503378
125MP0000371_diluted_coat_color0.84161884
126MP0002429_abnormal_blood_cell0.83524105
127MP0002837_dystrophic_cardiac_calcinosis0.83133684
128MP0005167_abnormal_blood-brain_barrier0.82593494
129MP0003866_abnormal_defecation0.82348882
130MP0009333_abnormal_splenocyte_physiolog0.81980162
131MP0005253_abnormal_eye_physiology0.81856032
132MP0005499_abnormal_olfactory_system0.81172452
133MP0005394_taste/olfaction_phenotype0.81172452
134MP0004510_myositis0.81105301
135MP0000751_myopathy0.80996020
136MP0000465_gastrointestinal_hemorrhage0.80317735
137MP0008874_decreased_physiological_sensi0.79538365
138MP0003632_abnormal_nervous_system0.79229848
139MP0002332_abnormal_exercise_endurance0.78709496
140MP0002722_abnormal_immune_system0.76780289
141MP0002277_abnormal_respiratory_mucosa0.74153661
142MP0001851_eye_inflammation0.72135005
143MP0001188_hyperpigmentation0.71585288
144MP0010234_abnormal_vibrissa_follicle0.71506089
145MP0001963_abnormal_hearing_physiology0.70757149
146MP0004742_abnormal_vestibular_system0.70319992
147MP0006054_spinal_hemorrhage0.69770722
148MP0002877_abnormal_melanocyte_morpholog0.67776918
149MP0004145_abnormal_muscle_electrophysio0.67737601
150MP0009763_increased_sensitivity_to0.67576510
151MP0001177_atelectasis0.67445281
152MP0002752_abnormal_somatic_nervous0.66942428
153MP0003795_abnormal_bone_structure0.66156460
154MP0003045_fibrosis0.64954306
155MP0005174_abnormal_tail_pigmentation0.64447475
156MP0003453_abnormal_keratinocyte_physiol0.64052959
157MP0004085_abnormal_heartbeat0.63522428
158MP0002876_abnormal_thyroid_physiology0.61796713
159MP0000631_abnormal_neuroendocrine_gland0.60502063
160MP0004215_abnormal_myocardial_fiber0.59074225
161MP0000920_abnormal_myelination0.58562988
162MP0001765_abnormal_ion_homeostasis0.55930081
163MP0001664_abnormal_digestion0.55397006
164MP0003123_paternal_imprinting0.53102695
165MP0005310_abnormal_salivary_gland0.52850262
166MP0003303_peritoneal_inflammation0.52131228
167MP0002693_abnormal_pancreas_physiology0.51864334

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.70191782
2Myokymia (HP:0002411)5.99650761
3Visual hallucinations (HP:0002367)5.50333929
4Eczematoid dermatitis (HP:0000976)5.22837993
5Focal seizures (HP:0007359)5.17693068
6Abnormality of macrophages (HP:0004311)5.11953537
7Recurrent bacterial skin infections (HP:0005406)4.95006915
8Recurrent abscess formation (HP:0002722)4.75356703
9Epileptic encephalopathy (HP:0200134)4.71468227
10Atonic seizures (HP:0010819)4.63034134
11Absence seizures (HP:0002121)4.34051173
12Febrile seizures (HP:0002373)4.26930533
13Supranuclear gaze palsy (HP:0000605)4.16400314
14Progressive cerebellar ataxia (HP:0002073)4.02151412
15Orchitis (HP:0100796)3.98889856
16Dialeptic seizures (HP:0011146)3.93559070
17Generalized tonic-clonic seizures (HP:0002069)3.91847443
18Retrobulbar optic neuritis (HP:0100654)3.91036485
19Optic neuritis (HP:0100653)3.91036485
20Recurrent gram-negative bacterial infections (HP:0005420)3.89025467
21Myositis (HP:0100614)3.83900464
22Loss of speech (HP:0002371)3.83456257
23Vacuolated lymphocytes (HP:0001922)3.78198419
24Stomatitis (HP:0010280)3.71036083
25Action tremor (HP:0002345)3.61902583
26Disinhibition (HP:0000734)3.58228957
27Depression (HP:0000716)3.43876852
28Mutism (HP:0002300)3.38709517
29Abnormal eating behavior (HP:0100738)3.21288048
30Mediastinal lymphadenopathy (HP:0100721)3.16702976
31Postural instability (HP:0002172)3.16579744
32Ankle clonus (HP:0011448)3.14384303
33Recurrent skin infections (HP:0001581)3.10861647
34Truncal ataxia (HP:0002078)3.07345964
35Pheochromocytoma (HP:0002666)3.00002044
36Poor eye contact (HP:0000817)2.98390123
37Systemic lupus erythematosus (HP:0002725)2.98021211
38Dysdiadochokinesis (HP:0002075)2.95759588
39Abnormality of polysaccharide metabolism (HP:0011012)2.93436731
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93436731
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93436731
42Papilledema (HP:0001085)2.91838161
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.85679909
44Anxiety (HP:0000739)2.84433637
45Chronic obstructive pulmonary disease (HP:0006510)2.84269732
46Obstructive lung disease (HP:0006536)2.84269732
47Impaired vibration sensation in the lower limbs (HP:0002166)2.81251564
48Gaze-evoked nystagmus (HP:0000640)2.79175455
49Urinary glycosaminoglycan excretion (HP:0003541)2.77920537
50Mucopolysacchariduria (HP:0008155)2.77920537
51Recurrent fungal infections (HP:0002841)2.77910143
52Impaired social interactions (HP:0000735)2.76206137
53Abnormal social behavior (HP:0012433)2.76206137
54Urinary bladder sphincter dysfunction (HP:0002839)2.75733473
55Amyloidosis (HP:0011034)2.71339456
56Gingivitis (HP:0000230)2.69824864
57Keratoconjunctivitis sicca (HP:0001097)2.69525955
58Dysmetria (HP:0001310)2.68935352
59Elevated erythrocyte sedimentation rate (HP:0003565)2.68833119
60Broad-based gait (HP:0002136)2.67945811
61Increased cerebral lipofuscin (HP:0011813)2.66758487
62Neuroendocrine neoplasm (HP:0100634)2.66334498
63Epileptiform EEG discharges (HP:0011182)2.63479705
64Abnormality of binocular vision (HP:0011514)2.61103134
65Diplopia (HP:0000651)2.61103134
66Abnormality of the lower motor neuron (HP:0002366)2.60990499
67Spontaneous hematomas (HP:0007420)2.60747260
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.59874000
69Bradykinesia (HP:0002067)2.59675004
70EEG with generalized epileptiform discharges (HP:0011198)2.56255141
71Impaired smooth pursuit (HP:0007772)2.55604715
72Amblyopia (HP:0000646)2.52158031
73Polyphagia (HP:0002591)2.51961728
74Gastrointestinal infarctions (HP:0005244)2.51565937
75Neurofibrillary tangles (HP:0002185)2.50254795
76Agitation (HP:0000713)2.50050223
77Recurrent cutaneous fungal infections (HP:0011370)2.48575395
78Chronic mucocutaneous candidiasis (HP:0002728)2.48575395
79Genetic anticipation (HP:0003743)2.47814517
80Cerebral inclusion bodies (HP:0100314)2.47737765
81Keratoconjunctivitis (HP:0001096)2.47353762
82Progressive inability to walk (HP:0002505)2.44226029
83Hemiparesis (HP:0001269)2.41521562
84Resting tremor (HP:0002322)2.39654134
85Neuronal loss in central nervous system (HP:0002529)2.39083131
86Urticaria (HP:0001025)2.37818158
87Torticollis (HP:0000473)2.37101390
88Ventricular fibrillation (HP:0001663)2.36673652
89Central scotoma (HP:0000603)2.36273829
90Urinary urgency (HP:0000012)2.35657043
91Hemoptysis (HP:0002105)2.35396633
92Pulmonary infiltrates (HP:0002113)2.35193844
93Meningitis (HP:0001287)2.34925659
94Hyperventilation (HP:0002883)2.34281082
95Hypsarrhythmia (HP:0002521)2.33465356
96Hemiplegia (HP:0002301)2.33083860
97Autoimmune thrombocytopenia (HP:0001973)2.32925255
98Vasculitis (HP:0002633)2.30866342
99Episodic fever (HP:0001954)2.30128284
100T lymphocytopenia (HP:0005403)2.28617814
101Agnosia (HP:0010524)2.27370248
102Abnormality of ocular smooth pursuit (HP:0000617)2.26914917
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26787054
104Failure to thrive in infancy (HP:0001531)2.26692695
105Progressive neurologic deterioration (HP:0002344)2.24671121
106Abnormality of glycolipid metabolism (HP:0010969)2.22910245
107Abnormality of liposaccharide metabolism (HP:0010968)2.22910245
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.22910245
109Increased CSF protein (HP:0002922)2.22336018
110Status epilepticus (HP:0002133)2.22202689
111Excessive salivation (HP:0003781)2.21953605
112Drooling (HP:0002307)2.21953605
113Dysmetric saccades (HP:0000641)2.20548396
114Memory impairment (HP:0002354)2.18445031
115Hypercortisolism (HP:0001578)2.18417580
116Focal dystonia (HP:0004373)2.17745704
117Encephalitis (HP:0002383)2.16926400
118Spastic gait (HP:0002064)2.16603343
119Hematochezia (HP:0002573)2.15893607
120Intention tremor (HP:0002080)2.15318462
121Purpura (HP:0000979)2.15211023
122Stereotypic behavior (HP:0000733)2.15014517
123Slow saccadic eye movements (HP:0000514)2.14301522
124Scanning speech (HP:0002168)2.14086153
125Peripheral hypomyelination (HP:0007182)2.12053297
126Apathy (HP:0000741)2.11116207
127Increased IgE level (HP:0003212)2.10476195
128Myocardial infarction (HP:0001658)2.10377604
129Generalized myoclonic seizures (HP:0002123)2.08744184
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07759418
131Upper motor neuron abnormality (HP:0002127)2.06986892
132Limb dystonia (HP:0002451)2.05485959
133Abnormality of T cell number (HP:0011839)2.04923931
134Petechiae (HP:0000967)2.04623016
135Rigidity (HP:0002063)2.03132822
136Menstrual irregularities (HP:0000858)2.02699187
137Termporal pattern (HP:0011008)2.01804283
138Insidious onset (HP:0003587)2.01804283
139Neoplasm of the peripheral nervous system (HP:0100007)2.00511941
140Leukocytosis (HP:0001974)1.99932531
141Hepatosplenomegaly (HP:0001433)1.98711465
142Lower limb muscle weakness (HP:0007340)1.98372466
143Cellulitis (HP:0100658)1.98220438
144Gingival bleeding (HP:0000225)1.97453898
145Axonal loss (HP:0003447)1.97433756
146Increased neuronal autofluorescent lipopigment (HP:0002074)1.97350323
147Gait ataxia (HP:0002066)1.96353101
148Dysostosis multiplex (HP:0000943)1.95628071
149Congenital stationary night blindness (HP:0007642)1.95458130
150Craniofacial dystonia (HP:0012179)1.95062729
151Psychosis (HP:0000709)1.94906216
152Diminished motivation (HP:0000745)1.94661079
153Nuclear cataract (HP:0100018)1.94102903
154Osteomyelitis (HP:0002754)1.93973594
155Abnormality of macular pigmentation (HP:0008002)1.93806375
156Abnormality of the periventricular white matter (HP:0002518)1.93624691
157Hypoventilation (HP:0002791)1.93393245
158Chest pain (HP:0100749)1.92556625
159Inability to walk (HP:0002540)1.92544842
160Pulmonary embolism (HP:0002204)1.91779844
161Global brain atrophy (HP:0002283)1.91770152
162Fetal akinesia sequence (HP:0001989)1.90884252
163Ocular albinism (HP:0001107)1.89897060
164Annular pancreas (HP:0001734)1.87703467
165Megalencephaly (HP:0001355)1.86930210
166Inappropriate behavior (HP:0000719)1.86846709
167Arterial thrombosis (HP:0004420)1.86559523
168Vertigo (HP:0002321)1.86548636
169Abnormal delayed hypersensitivity skin test (HP:0002963)1.85866211
170Impaired vibratory sensation (HP:0002495)1.85461329
171Dementia (HP:0000726)1.85310548
172Absent speech (HP:0001344)1.84489968
173Gangrene (HP:0100758)1.83216113
174Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82335452
175Interstitial pulmonary disease (HP:0006530)1.79306475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.46720806
2NTRK34.38007670
3EPHA43.39477086
4MAP3K43.10618296
5MINK12.88200467
6BLK2.81866931
7KSR22.69465480
8DAPK22.63219690
9PAK62.55544835
10MAP2K72.45867155
11MARK12.43413449
12TYK22.41340810
13MAP3K122.34568775
14RIPK42.31788085
15PRKD32.23951718
16IRAK42.23825052
17CSK2.19314392
18FGR2.10497915
19CAMKK12.10349077
20MAP3K142.03215754
21MAP2K32.01548587
22NTRK12.01471604
23ARAF2.00249835
24IRAK31.93386087
25MAP2K41.92811707
26MAP3K111.91011895
27MAP4K11.79396546
28CAMKK21.74448034
29DAPK11.73199521
30EPHB11.72441817
31MAP3K31.70436762
32MAP3K131.69066763
33CASK1.59946158
34PLK21.57045052
35MAP3K21.56645064
36KSR11.56228272
37ZAP701.54968816
38STK381.54556265
39NTRK21.53953580
40CDK51.51109462
41MATK1.47412296
42GRK51.46724352
43GRK71.45823472
44NEK11.44685758
45TXK1.39772724
46PRPF4B1.37372534
47JAK21.37312480
48ERN11.36514532
49JAK11.32084622
50SYK1.30920974
51TBK11.28917553
52TGFBR21.28420683
53CDK191.27093722
54FES1.25750149
55EPHA31.20237297
56IRAK21.20220532
57IKBKE1.19148208
58PRKCG1.18934085
59HCK1.16997423
60TAOK21.16652495
61SCYL21.13354453
62JAK31.10294560
63IRAK11.09840138
64TAOK31.05624571
65PINK11.01102932
66SGK2231.00200073
67SGK4941.00200073
68UHMK11.00078831
69LYN0.99227668
70MAP3K10.99106043
71PRKCH0.97940600
72SIK20.95849464
73ACVR1B0.94136599
74RET0.94035165
75TAOK10.93760431
76MARK30.92629574
77CDK140.91577147
78CDK180.88157480
79CDK150.85622504
80WNK30.85545730
81MAPK130.85336450
82CAMK2A0.84355093
83ALK0.83516003
84LMTK20.80872556
85MAPK120.80662454
86MAP3K50.80452606
87PHKG20.80398189
88PHKG10.80398189
89CSF1R0.80171909
90YES10.79072305
91RAF10.78959671
92PNCK0.77565572
93GRK60.76900721
94SGK20.76213750
95DDR20.75918276
96SGK30.74112013
97LCK0.73651024
98IKBKB0.72791387
99CDK11A0.72595529
100BMPR20.71756870
101BTK0.71715902
102CAMK10.71667882
103PAK30.71175982
104FGFR30.69549857
105RIPK10.68164054
106OXSR10.68062378
107PDK10.66958207
108LATS20.66645604
109DYRK1A0.66522113
110PDPK10.65947891
111FER0.65779666
112STK110.64349812
113BRAF0.64258320
114TYRO30.63201635
115SGK10.62802916
116KIT0.62610239
117MAP2K60.61230854
118PTK2B0.59613330
119TNIK0.56555955
120CAMK2B0.56487737
121PRKCE0.56194276
122BRSK10.54928273
123MAP2K10.53672171
124PDK20.53261503
125CSNK1G20.51832605
126TNK20.51217492
127PRKCZ0.48631579
128MAPK70.48601156
129CCNB10.47353240
130CAMK40.47159128
131ITK0.46846965
132WNK10.46729293
133AKT30.46325600
134CAMK1D0.45550562
135RPS6KA30.45504104
136CAMK2D0.45394050
137DAPK30.43921724
138MAP3K60.43353277
139NEK60.43151571
140CDC42BPA0.42248572
141MAPK100.42077468
142PRKD20.41112083
143NME10.41020056
144SIK30.38677202
145FYN0.38397862
146CAMK2G0.37510890
147RPS6KA20.37291044
148HIPK20.36629258
149TESK20.36365070
150MARK20.34707446
151MOS0.32889652
152WNK40.30894788
153PRKCB0.30885807
154CAMK1G0.29230482
155PRKCA0.28826309

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047214.03794692
2Nicotine addiction_Homo sapiens_hsa050333.37720437
3Osteoclast differentiation_Homo sapiens_hsa043802.73117045
4GABAergic synapse_Homo sapiens_hsa047272.72143737
5Olfactory transduction_Homo sapiens_hsa047402.59577361
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.53778453
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51207242
8Circadian entrainment_Homo sapiens_hsa047132.45297078
9Morphine addiction_Homo sapiens_hsa050322.41559986
10Leishmaniasis_Homo sapiens_hsa051402.41259107
11Staphylococcus aureus infection_Homo sapiens_hsa051502.37723809
12Long-term potentiation_Homo sapiens_hsa047202.35175987
13Other glycan degradation_Homo sapiens_hsa005112.29927261
14Insulin secretion_Homo sapiens_hsa049112.20129693
15* Collecting duct acid secretion_Homo sapiens_hsa049662.19874772
16Glutamatergic synapse_Homo sapiens_hsa047242.18054372
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16060735
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15987956
19Amphetamine addiction_Homo sapiens_hsa050312.13915708
20Dopaminergic synapse_Homo sapiens_hsa047282.03150423
21Salivary secretion_Homo sapiens_hsa049701.93508532
22Cholinergic synapse_Homo sapiens_hsa047251.80200823
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70637461
24Gastric acid secretion_Homo sapiens_hsa049711.69752051
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66122641
26Taste transduction_Homo sapiens_hsa047421.63114195
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61132638
28Allograft rejection_Homo sapiens_hsa053301.58781065
29Renin secretion_Homo sapiens_hsa049241.58199143
30Legionellosis_Homo sapiens_hsa051341.58101437
31Malaria_Homo sapiens_hsa051441.57345851
32Graft-versus-host disease_Homo sapiens_hsa053321.55549785
33* Vibrio cholerae infection_Homo sapiens_hsa051101.52661613
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50338229
35Serotonergic synapse_Homo sapiens_hsa047261.49197365
36Cocaine addiction_Homo sapiens_hsa050301.46699126
37Oxytocin signaling pathway_Homo sapiens_hsa049211.45968789
38Long-term depression_Homo sapiens_hsa047301.45758087
39B cell receptor signaling pathway_Homo sapiens_hsa046621.45424031
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44463349
41Pertussis_Homo sapiens_hsa051331.43479178
42Salmonella infection_Homo sapiens_hsa051321.43319354
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42552188
44Type II diabetes mellitus_Homo sapiens_hsa049301.37121708
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30206792
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30120496
47Autoimmune thyroid disease_Homo sapiens_hsa053201.30078347
48Calcium signaling pathway_Homo sapiens_hsa040201.29336674
49GnRH signaling pathway_Homo sapiens_hsa049121.29023091
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.28881858
51TNF signaling pathway_Homo sapiens_hsa046681.27485785
52Antigen processing and presentation_Homo sapiens_hsa046121.25293629
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23522010
54Toxoplasmosis_Homo sapiens_hsa051451.21973341
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21794231
56Gap junction_Homo sapiens_hsa045401.19137860
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15333446
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14999430
59Asthma_Homo sapiens_hsa053101.09538381
60cAMP signaling pathway_Homo sapiens_hsa040241.07588512
61Influenza A_Homo sapiens_hsa051641.06617308
62Hematopoietic cell lineage_Homo sapiens_hsa046401.06102326
63Estrogen signaling pathway_Homo sapiens_hsa049151.05265955
64African trypanosomiasis_Homo sapiens_hsa051431.03482352
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03296081
66Glioma_Homo sapiens_hsa052141.03038152
67* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01803012
68Phototransduction_Homo sapiens_hsa047441.00905349
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99523563
70Type I diabetes mellitus_Homo sapiens_hsa049400.98280488
71Measles_Homo sapiens_hsa051620.94818361
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93080603
73T cell receptor signaling pathway_Homo sapiens_hsa046600.92713830
74Lysosome_Homo sapiens_hsa041420.92173450
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90014819
76Acute myeloid leukemia_Homo sapiens_hsa052210.89903409
77Shigellosis_Homo sapiens_hsa051310.89186507
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88733540
79ErbB signaling pathway_Homo sapiens_hsa040120.85940546
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83400339
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.83002186
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.80549522
83Oocyte meiosis_Homo sapiens_hsa041140.78803512
84Pancreatic secretion_Homo sapiens_hsa049720.78614703
85Hepatitis B_Homo sapiens_hsa051610.78413621
86Hepatitis C_Homo sapiens_hsa051600.77860694
87Viral myocarditis_Homo sapiens_hsa054160.76358725
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.76127171
89Melanogenesis_Homo sapiens_hsa049160.75927998
90Thyroid hormone synthesis_Homo sapiens_hsa049180.75018125
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.73356177
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.72771947
93Cardiac muscle contraction_Homo sapiens_hsa042600.72564244
94Dorso-ventral axis formation_Homo sapiens_hsa043200.72029344
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69670469
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69043686
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68641920
98mTOR signaling pathway_Homo sapiens_hsa041500.67483029
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67426109
100Amoebiasis_Homo sapiens_hsa051460.67295245
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.66765313
102Inositol phosphate metabolism_Homo sapiens_hsa005620.66343799
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66153879
104Platelet activation_Homo sapiens_hsa046110.66054254
105Endocytosis_Homo sapiens_hsa041440.64601531
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.63723807
107Apoptosis_Homo sapiens_hsa042100.63431369
108* Rheumatoid arthritis_Homo sapiens_hsa053230.61827188
109Circadian rhythm_Homo sapiens_hsa047100.61024084
110* Phagosome_Homo sapiens_hsa041450.60574588
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60359805
112MAPK signaling pathway_Homo sapiens_hsa040100.59893302
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58765565
114Choline metabolism in cancer_Homo sapiens_hsa052310.58085729
115Glucagon signaling pathway_Homo sapiens_hsa049220.57543888
116Herpes simplex infection_Homo sapiens_hsa051680.57409249
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57227998
118Axon guidance_Homo sapiens_hsa043600.56128744
119HIF-1 signaling pathway_Homo sapiens_hsa040660.56027660
120VEGF signaling pathway_Homo sapiens_hsa043700.56008319
121Sphingolipid metabolism_Homo sapiens_hsa006000.55987609
122Dilated cardiomyopathy_Homo sapiens_hsa054140.55560874
123Nitrogen metabolism_Homo sapiens_hsa009100.53724549
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.52626356
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51329249
126Prion diseases_Homo sapiens_hsa050200.50581511
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49574197
128Primary immunodeficiency_Homo sapiens_hsa053400.46917352
129Insulin signaling pathway_Homo sapiens_hsa049100.46114280
130Ras signaling pathway_Homo sapiens_hsa040140.44008021
131Chemokine signaling pathway_Homo sapiens_hsa040620.43803653
132Renal cell carcinoma_Homo sapiens_hsa052110.42556504
133Endometrial cancer_Homo sapiens_hsa052130.42541104
134Alcoholism_Homo sapiens_hsa050340.42014821
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41992922
136Tuberculosis_Homo sapiens_hsa051520.40780671
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38920971
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38039197
139Rap1 signaling pathway_Homo sapiens_hsa040150.37858828
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.36504922
141Regulation of autophagy_Homo sapiens_hsa041400.36270538
142Non-small cell lung cancer_Homo sapiens_hsa052230.35644638
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.35430842
144Mineral absorption_Homo sapiens_hsa049780.34838050
145Bile secretion_Homo sapiens_hsa049760.34181754
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33490110
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30482109
148Prolactin signaling pathway_Homo sapiens_hsa049170.30232961
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30179269

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