ATP6V1C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.00937380
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.37421230
3regulation of synaptic vesicle exocytosis (GO:2000300)5.21096444
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.10480771
5glutamate secretion (GO:0014047)5.08614772
6vocalization behavior (GO:0071625)4.96728696
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.91384725
8neuronal action potential propagation (GO:0019227)4.84431438
9neuron cell-cell adhesion (GO:0007158)4.79414064
10* ATP hydrolysis coupled proton transport (GO:0015991)4.76263706
11* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.76263706
12* transferrin transport (GO:0033572)4.71727989
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.68083738
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.61821795
15regulation of synaptic vesicle transport (GO:1902803)4.59438666
16regulation of glutamate receptor signaling pathway (GO:1900449)4.46951819
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44694232
18synaptic vesicle maturation (GO:0016188)4.44432547
19protein localization to synapse (GO:0035418)4.39702932
20* trivalent inorganic cation transport (GO:0072512)4.37645560
21* ferric iron transport (GO:0015682)4.37645560
22neurotransmitter secretion (GO:0007269)4.28043137
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.15668994
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.15634666
25sodium ion export (GO:0071436)4.12553749
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10430062
27neurotransmitter-gated ion channel clustering (GO:0072578)4.09448033
28neuron-neuron synaptic transmission (GO:0007270)4.07694239
29presynaptic membrane assembly (GO:0097105)4.03499473
30locomotory exploration behavior (GO:0035641)3.95349302
31protein localization to endosome (GO:0036010)3.88784853
32synaptic transmission, glutamatergic (GO:0035249)3.88711962
33* phagosome maturation (GO:0090382)3.88167891
34glutamate receptor signaling pathway (GO:0007215)3.85475585
35response to histamine (GO:0034776)3.85067246
36long-term synaptic potentiation (GO:0060291)3.83581243
37presynaptic membrane organization (GO:0097090)3.74815351
38L-amino acid import (GO:0043092)3.66143760
39amino acid import (GO:0043090)3.62811203
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54638183
41neurotransmitter transport (GO:0006836)3.53495800
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52843755
43proline transport (GO:0015824)3.52418525
44postsynaptic membrane organization (GO:0001941)3.50416917
45melanin biosynthetic process (GO:0042438)3.49618471
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46584180
47positive regulation of synapse maturation (GO:0090129)3.45734716
48regulation of neuronal synaptic plasticity (GO:0048168)3.43386871
49positive regulation of membrane potential (GO:0045838)3.41689183
50neuromuscular process controlling posture (GO:0050884)3.41113368
51synaptic vesicle endocytosis (GO:0048488)3.38136815
52regulation of postsynaptic membrane potential (GO:0060078)3.37300944
53regulation of neurotransmitter secretion (GO:0046928)3.35164988
54exploration behavior (GO:0035640)3.30548718
55regulation of synaptic plasticity (GO:0048167)3.30248617
56regulation of clathrin-mediated endocytosis (GO:2000369)3.28641442
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.28024777
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26033141
59regulation of neurotransmitter levels (GO:0001505)3.25682183
60gamma-aminobutyric acid transport (GO:0015812)3.25463846
61oligosaccharide catabolic process (GO:0009313)3.23708143
62startle response (GO:0001964)3.21245547
63cellular response to thyroid hormone stimulus (GO:0097067)3.20947728
64negative regulation of dendrite morphogenesis (GO:0050774)3.18843577
65regulation of synapse structural plasticity (GO:0051823)3.18223723
66positive regulation of neurotransmitter transport (GO:0051590)3.17105152
67establishment of synaptic vesicle localization (GO:0097480)3.16747461
68synaptic vesicle transport (GO:0048489)3.16747461
69detection of calcium ion (GO:0005513)3.14293983
70glycosphingolipid catabolic process (GO:0046479)3.12691535
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12341571
72regulation of glutamate secretion (GO:0014048)3.12267682
73clathrin coat assembly (GO:0048268)3.12060778
74cerebellar granule cell differentiation (GO:0021707)3.11507373
75regulation of neurotransmitter transport (GO:0051588)3.10404452
76long-term memory (GO:0007616)3.06141100
77positive regulation of neurotransmitter secretion (GO:0001956)3.05471394
78behavioral response to cocaine (GO:0048148)3.05464885
79regulation of vesicle fusion (GO:0031338)3.04989801
80negative regulation of amino acid transport (GO:0051956)3.03000659
81negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.01866562
82vesicle docking (GO:0048278)3.00556633
83positive regulation of synaptic transmission (GO:0050806)2.99878595
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98439231
85neuron recognition (GO:0008038)2.98438630
86synaptic transmission (GO:0007268)2.98431255
87establishment of vesicle localization (GO:0051650)2.95877694
88melanin metabolic process (GO:0006582)2.95753282
89regulation of early endosome to late endosome transport (GO:2000641)2.93624061
90vesicle docking involved in exocytosis (GO:0006904)2.93376429
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93022078
92activation of protein kinase A activity (GO:0034199)2.92638027
93striatum development (GO:0021756)2.91903803
94cellular potassium ion homeostasis (GO:0030007)2.91894518
95membrane depolarization (GO:0051899)2.90016762
96cerebellar Purkinje cell differentiation (GO:0021702)2.89661996
97positive regulation of protein autophosphorylation (GO:0031954)2.88981357
98NADH metabolic process (GO:0006734)2.88693926
99long term synaptic depression (GO:0060292)2.87948883
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86717784
101acidic amino acid transport (GO:0015800)2.86052652
102regulation of synaptic transmission (GO:0050804)2.85912747
103negative regulation of protein localization to plasma membrane (GO:1903077)2.83760397
104regulation of voltage-gated calcium channel activity (GO:1901385)2.83424874
105mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.83022628
106vesicle transport along microtubule (GO:0047496)2.82271562
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82166941
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81661530
109glycolipid catabolic process (GO:0019377)2.81196827
110behavioral defense response (GO:0002209)2.80976292
111behavioral fear response (GO:0001662)2.80976292
112calcium ion-dependent exocytosis (GO:0017156)2.80039511
113righting reflex (GO:0060013)2.79234076
114regulation of exocytosis (GO:0017157)2.78811095
115* iron ion transport (GO:0006826)2.78169838
116regulation of Rac protein signal transduction (GO:0035020)2.77422479
117cytoskeletal anchoring at plasma membrane (GO:0007016)2.76312116
118regulation of synapse maturation (GO:0090128)2.75744739
119positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75700191
120neurotransmitter uptake (GO:0001504)2.74809597
121response to thyroid hormone (GO:0097066)2.74579954
122serotonin metabolic process (GO:0042428)2.74545438
123potassium ion homeostasis (GO:0055075)2.74169386
124membrane depolarization during action potential (GO:0086010)2.73918979
125fear response (GO:0042596)2.73225905
126negative regulation of neurotransmitter transport (GO:0051589)2.72914753
127negative regulation of response to reactive oxygen species (GO:1901032)2.70480726
128cellular copper ion homeostasis (GO:0006878)2.61744124
129secondary metabolite biosynthetic process (GO:0044550)2.60644647
130membrane docking (GO:0022406)2.60398685
131dicarboxylic acid biosynthetic process (GO:0043650)2.60384256
132iron ion import (GO:0097286)2.58891519
133Rap protein signal transduction (GO:0032486)2.56910053
134regulation of dendritic spine development (GO:0060998)2.55888043
135ganglioside metabolic process (GO:0001573)2.55697864
136L-glutamate transport (GO:0015813)2.55563945
137positive regulation of vesicle fusion (GO:0031340)2.54229600
138regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53902473
139inositol phosphate catabolic process (GO:0071545)2.53468482
140positive regulation of macroautophagy (GO:0016239)2.52522964
141COPI coating of Golgi vesicle (GO:0048205)2.52494918
142Golgi transport vesicle coating (GO:0048200)2.52494918
143ceramide catabolic process (GO:0046514)2.52209722
144inositol phosphate dephosphorylation (GO:0046855)2.49737849
145phosphorylated carbohydrate dephosphorylation (GO:0046838)2.49737849
146regulation of hydrogen peroxide-induced cell death (GO:1903205)2.47896918
147nerve growth factor signaling pathway (GO:0038180)2.46109475
148vesicle coating (GO:0006901)2.45937938
149sphingosine metabolic process (GO:0006670)2.45881766
150response to methylmercury (GO:0051597)2.44503892
151layer formation in cerebral cortex (GO:0021819)2.43042219
152neuromuscular process controlling balance (GO:0050885)2.43001084
153regulation of beta-amyloid formation (GO:1902003)2.42150231
154intracellular pH reduction (GO:0051452)2.40660312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52370369
2GBX2_23144817_ChIP-Seq_PC3_Human4.68392363
3REST_21632747_ChIP-Seq_MESCs_Mouse3.03787002
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99744102
5TAF15_26573619_Chip-Seq_HEK293_Human2.97553581
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.77064942
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76628934
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71777988
9* TFEB_21752829_ChIP-Seq_HELA_Human2.67906634
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59103363
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58425268
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.53325820
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45760456
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43392622
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.40538700
16* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.38384218
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27644065
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23976664
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19050931
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18697749
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18070974
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17011307
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15881017
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15751352
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15249254
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10263067
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10263067
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02935033
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02916510
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99021607
31SMAD4_21799915_ChIP-Seq_A2780_Human1.97049635
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.96235451
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90145824
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.87659169
35VDR_22108803_ChIP-Seq_LS180_Human1.87576654
36* P300_19829295_ChIP-Seq_ESCs_Human1.86112812
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.85857145
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.83983397
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80998378
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.80407675
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78115260
42* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77416526
43GATA1_22025678_ChIP-Seq_K562_Human1.72586439
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71461665
45IGF1R_20145208_ChIP-Seq_DFB_Human1.69847951
46AR_21909140_ChIP-Seq_LNCAP_Human1.68248671
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68072441
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66635927
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64957523
50DROSHA_22980978_ChIP-Seq_HELA_Human1.64730907
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63615601
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.63041654
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.61617220
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61394557
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.61218773
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58776301
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.57654073
58* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56825889
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54985443
60FUS_26573619_Chip-Seq_HEK293_Human1.54943789
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54028250
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.53696467
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53049441
64AR_25329375_ChIP-Seq_VCAP_Human1.52397578
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.52003012
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47927058
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47647909
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47269251
69ER_23166858_ChIP-Seq_MCF-7_Human1.46113571
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44844292
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41523160
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.41149633
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.39709764
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.37260628
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36649143
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36104901
77P300_18555785_Chip-Seq_ESCs_Mouse1.35971976
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35053741
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33974515
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33854280
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32580264
82PU1_27457419_Chip-Seq_LIVER_Mouse1.30958743
83CLOCK_20551151_ChIP-Seq_293T_Human1.30629064
84JUN_21703547_ChIP-Seq_K562_Human1.30169884
85SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29390072
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.29126388
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28589808
88STAT3_23295773_ChIP-Seq_U87_Human1.28071814
89AR_21572438_ChIP-Seq_LNCaP_Human1.27895599
90* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27482325
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27309801
92ZNF274_21170338_ChIP-Seq_K562_Hela1.26031574
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24897946
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24691538
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24312730
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.23712610
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23123372
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.22782036
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.21689885
100TCF4_23295773_ChIP-Seq_U87_Human1.20698475
101RNF2_27304074_Chip-Seq_NSC_Mouse1.20134998
102KLF4_18555785_Chip-Seq_ESCs_Mouse1.19520374
103* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19253553
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.18777031
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.18493243
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.18405170
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.18323760
108* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18174362
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.17719363
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.16412521
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16383807
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.16325431
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16100994
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15143084
115SOX2_20726797_ChIP-Seq_SW620_Human1.14674912
116* PRDM14_20953172_ChIP-Seq_ESCs_Human1.14458083
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.13577935
118* CJUN_26792858_Chip-Seq_BT549_Human1.13339549
119RUNX2_22187159_ChIP-Seq_PCA_Human1.12949402
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12594195
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11675243
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11405636
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.11400671
124TP53_18474530_ChIP-ChIP_U2OS_Human1.10301986
125ESRRB_18555785_Chip-Seq_ESCs_Mouse1.09547319
126PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08692954
127* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08533865
128TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08204077
129ZFX_18555785_Chip-Seq_ESCs_Mouse1.07982882
130BRD4_25478319_ChIP-Seq_HGPS_Human1.06283067
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06145827
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05310713
133ELF5_23300383_ChIP-Seq_T47D_Human1.04992930
134FLI1_27457419_Chip-Seq_LIVER_Mouse1.04948142
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04440921
136CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04247444
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03154400
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00231182
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99995112
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98579910
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.98123988
142P53_22387025_ChIP-Seq_ESCs_Mouse0.97443301
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97293339
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.97022227
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95130421
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94967693
147CBX2_27304074_Chip-Seq_ESCs_Mouse0.94941606
148CMYC_18555785_Chip-Seq_ESCs_Mouse0.94931757
149IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93723274
150CBP_20019798_ChIP-Seq_JUKART_Human0.93723274
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93224764
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92171177
153NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92171177
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92148343
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.91533611
156AR_19668381_ChIP-Seq_PC3_Human0.91283814
157KDM2B_26808549_Chip-Seq_REH_Human0.90352052
158CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89871505
159PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89842674
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.88141098
161REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88125852
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.88017051
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88002460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.33022261
2MP0004859_abnormal_synaptic_plasticity5.31253696
3MP0010234_abnormal_vibrissa_follicle3.94395908
4MP0003635_abnormal_synaptic_transmissio3.85370187
5MP0009046_muscle_twitch3.62390315
6MP0002877_abnormal_melanocyte_morpholog3.46549301
7MP0002064_seizures3.45165469
8MP0009745_abnormal_behavioral_response3.44405019
9MP0004270_analgesia3.34039472
10MP0001968_abnormal_touch/_nociception3.29310007
11MP0002063_abnormal_learning/memory/cond3.13352202
12MP0002736_abnormal_nociception_after2.91183853
13MP0002572_abnormal_emotion/affect_behav2.83768373
14MP0003950_abnormal_plasma_membrane2.76656785
15MP0002734_abnormal_mechanical_nocicepti2.66086529
16MP0002272_abnormal_nervous_system2.65415633
17MP0001501_abnormal_sleep_pattern2.63220894
18MP0002735_abnormal_chemical_nociception2.62302522
19MP0003656_abnormal_erythrocyte_physiolo2.31484428
20MP0001440_abnormal_grooming_behavior2.31426915
21MP0002822_catalepsy2.28805507
22MP0004147_increased_porphyrin_level2.20864861
23MP0002733_abnormal_thermal_nociception2.12259502
24MP0002067_abnormal_sensory_capabilities2.11439763
25MP0001970_abnormal_pain_threshold2.11108370
26MP0001486_abnormal_startle_reflex2.09475287
27MP0000015_abnormal_ear_pigmentation2.01730654
28MP0009780_abnormal_chondrocyte_physiolo1.95443804
29MP0003879_abnormal_hair_cell1.93325818
30MP0006276_abnormal_autonomic_nervous1.89813021
31MP0000372_irregular_coat_pigmentation1.89714937
32MP0010386_abnormal_urinary_bladder1.88300573
33MP0003329_amyloid_beta_deposits1.87046859
34MP0003191_abnormal_cellular_cholesterol1.84850793
35MP0001529_abnormal_vocalization1.81313564
36MP0002876_abnormal_thyroid_physiology1.76664200
37MP0005646_abnormal_pituitary_gland1.76274716
38MP0001984_abnormal_olfaction1.71899425
39MP0005423_abnormal_somatic_nervous1.69887700
40MP0000371_diluted_coat_color1.65452271
41MP0005386_behavior/neurological_phenoty1.65279064
42MP0004924_abnormal_behavior1.65279064
43MP0001905_abnormal_dopamine_level1.63971220
44MP0003183_abnormal_peptide_metabolism1.63311504
45MP0005408_hypopigmentation1.62790952
46MP0002837_dystrophic_cardiac_calcinosis1.62004978
47MP0002909_abnormal_adrenal_gland1.60390712
48MP0003787_abnormal_imprinting1.55741773
49MP0008569_lethality_at_weaning1.53414930
50MP0000013_abnormal_adipose_tissue1.51244455
51MP0002184_abnormal_innervation1.50573524
52MP0002557_abnormal_social/conspecific_i1.49707207
53MP0004811_abnormal_neuron_physiology1.49391154
54MP0005174_abnormal_tail_pigmentation1.48955340
55MP0010352_gastrointestinal_tract_polyps1.46657342
56MP0003122_maternal_imprinting1.46486979
57MP0005645_abnormal_hypothalamus_physiol1.44643447
58MP0004142_abnormal_muscle_tone1.44149685
59MP0002066_abnormal_motor_capabilities/c1.35696704
60MP0003633_abnormal_nervous_system1.34091591
61MP0009840_abnormal_foam_cell1.29430548
62MP0000604_amyloidosis1.29163238
63MP0005167_abnormal_blood-brain_barrier1.27403917
64MP0003172_abnormal_lysosome_physiology1.23509216
65MP0004858_abnormal_nervous_system1.19068430
66MP0008260_abnormal_autophagy1.19057447
67MP0006054_spinal_hemorrhage1.18384193
68MP0006082_CNS_inflammation1.17697504
69MP0010678_abnormal_skin_adnexa1.16307888
70MP0000955_abnormal_spinal_cord1.16227659
71MP0002882_abnormal_neuron_morphology1.16192950
72MP0004043_abnormal_pH_regulation1.16129479
73MP0001502_abnormal_circadian_rhythm1.15693711
74MP0005058_abnormal_lysosome_morphology1.15675352
75MP0001177_atelectasis1.14294128
76MP0001188_hyperpigmentation1.14031072
77MP0003631_nervous_system_phenotype1.13388911
78MP0000778_abnormal_nervous_system1.13263358
79MP0005257_abnormal_intraocular_pressure1.13123925
80MP0000343_altered_response_to1.11787297
81MP0005248_abnormal_Harderian_gland1.08653743
82MP0002229_neurodegeneration1.07659233
83MP0005535_abnormal_body_temperature1.00503676
84MP0003806_abnormal_nucleotide_metabolis0.97795477
85MP0002095_abnormal_skin_pigmentation0.97384382
86MP0002090_abnormal_vision0.96637151
87MP0008872_abnormal_physiological_respon0.92567691
88MP0001986_abnormal_taste_sensitivity0.91749831
89MP0002069_abnormal_eating/drinking_beha0.91113574
90MP0002638_abnormal_pupillary_reflex0.88696751
91MP0003221_abnormal_cardiomyocyte_apopto0.87354028
92MP0008877_abnormal_DNA_methylation0.86504454
93MP0005171_absent_coat_pigmentation0.85740234
94MP0005310_abnormal_salivary_gland0.85393405
95MP0005551_abnormal_eye_electrophysiolog0.84765718
96MP0003634_abnormal_glial_cell0.84547431
97MP0005075_abnormal_melanosome_morpholog0.82968638
98MP0008874_decreased_physiological_sensi0.82038690
99MP0001963_abnormal_hearing_physiology0.81932293
100MP0003690_abnormal_glial_cell0.79458347
101MP0003632_abnormal_nervous_system0.77818193
102MP0002152_abnormal_brain_morphology0.76427682
103MP0004510_myositis0.75114191
104MP0003646_muscle_fatigue0.75091768
105MP0005165_increased_susceptibility_to0.73868088
106MP0000358_abnormal_cell_content/0.73179763
107MP0006035_abnormal_mitochondrial_morpho0.72907330
108MP0000427_abnormal_hair_cycle0.72826513
109MP0004742_abnormal_vestibular_system0.72750309
110MP0004145_abnormal_muscle_electrophysio0.71326797
111MP0001664_abnormal_digestion0.71277184
112MP0004484_altered_response_of0.71147193
113MP0003075_altered_response_to0.69914937
114MP0003186_abnormal_redox_activity0.69910177
115MP0000751_myopathy0.69373438
116MP0001186_pigmentation_phenotype0.66502989
117MP0003448_altered_tumor_morphology0.64495269
118MP0004085_abnormal_heartbeat0.64390792
119MP0000920_abnormal_myelination0.64258782
120MP0008057_abnormal_DNA_replication0.64129432
121MP0004215_abnormal_myocardial_fiber0.62582773
122MP0002139_abnormal_hepatobiliary_system0.61628042
123MP0005166_decreased_susceptibility_to0.61418332
124MP0002075_abnormal_coat/hair_pigmentati0.60884627
125MP0000747_muscle_weakness0.60733903
126MP0010307_abnormal_tumor_latency0.60522895
127MP0004885_abnormal_endolymph0.60081696
128MP0002332_abnormal_exercise_endurance0.59546117
129MP0005384_cellular_phenotype0.58037461
130MP0004233_abnormal_muscle_weight0.57808588
131MP0001324_abnormal_eye_pigmentation0.57528189
132MP0001765_abnormal_ion_homeostasis0.57069140
133MP0002254_reproductive_system_inflammat0.56881308
134MP0005621_abnormal_cell_physiology0.56602561
135MP0005379_endocrine/exocrine_gland_phen0.56416413
136MP0003195_calcinosis0.56250073
137MP0006036_abnormal_mitochondrial_physio0.55940525
138MP0002752_abnormal_somatic_nervous0.54240829
139MP0000569_abnormal_digit_pigmentation0.53936549
140MP0003123_paternal_imprinting0.53585922
141MP0002693_abnormal_pancreas_physiology0.52285053
142MP0004036_abnormal_muscle_relaxation0.51848496

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.05456805
2Atonic seizures (HP:0010819)5.85355117
3Epileptic encephalopathy (HP:0200134)5.34491856
4Focal seizures (HP:0007359)5.26532783
5Febrile seizures (HP:0002373)4.89294656
6Myokymia (HP:0002411)4.88142225
7Visual hallucinations (HP:0002367)4.77051216
8Absence seizures (HP:0002121)4.73210972
9Dialeptic seizures (HP:0011146)4.48252191
10Hyperventilation (HP:0002883)4.03418288
11Generalized tonic-clonic seizures (HP:0002069)4.02066432
12Apathy (HP:0000741)3.67864094
13Disinhibition (HP:0000734)3.54885418
14Progressive cerebellar ataxia (HP:0002073)3.51334176
15Diminished motivation (HP:0000745)3.51243805
16Pheochromocytoma (HP:0002666)3.45130874
17Neuroendocrine neoplasm (HP:0100634)3.33753638
18Polyphagia (HP:0002591)3.21804871
19Abnormal eating behavior (HP:0100738)3.21297161
20Loss of speech (HP:0002371)3.09971428
21Acute necrotizing encephalopathy (HP:0006965)3.04751070
22Abnormal hair whorl (HP:0010721)3.00572142
23Abnormal mitochondria in muscle tissue (HP:0008316)3.00480871
24Intention tremor (HP:0002080)2.89471094
25Gait imbalance (HP:0002141)2.87050204
26Broad-based gait (HP:0002136)2.86285419
27Supranuclear gaze palsy (HP:0000605)2.84251173
28Gaze-evoked nystagmus (HP:0000640)2.80233672
29Hypokinesia (HP:0002375)2.79302093
30Tetraplegia (HP:0002445)2.77924286
31Medial flaring of the eyebrow (HP:0010747)2.75195505
32Progressive inability to walk (HP:0002505)2.73751500
33Progressive macrocephaly (HP:0004481)2.73631405
34Abnormality of the corticospinal tract (HP:0002492)2.72442157
35Truncal ataxia (HP:0002078)2.69765563
36Congenital primary aphakia (HP:0007707)2.68829255
37Epileptiform EEG discharges (HP:0011182)2.68460438
38Dysostosis multiplex (HP:0000943)2.67571180
39Vacuolated lymphocytes (HP:0001922)2.66490345
40Ocular albinism (HP:0001107)2.66021764
41Impaired vibration sensation in the lower limbs (HP:0002166)2.65699103
42Urinary urgency (HP:0000012)2.65448815
43Abnormality of binocular vision (HP:0011514)2.64122241
44Diplopia (HP:0000651)2.64122241
45Amblyopia (HP:0000646)2.63375068
46Cerebral hypomyelination (HP:0006808)2.62690201
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.61861056
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61861056
49Failure to thrive in infancy (HP:0001531)2.60643203
50Inappropriate behavior (HP:0000719)2.59047698
51Nephrogenic diabetes insipidus (HP:0009806)2.55412211
52Agnosia (HP:0010524)2.54957547
53Axonal loss (HP:0003447)2.53434903
54Depression (HP:0000716)2.51868471
55Papillary thyroid carcinoma (HP:0002895)2.50393538
56Resting tremor (HP:0002322)2.48266808
57Anxiety (HP:0000739)2.48119461
58Poor eye contact (HP:0000817)2.46718005
59Mitochondrial inheritance (HP:0001427)2.46001014
60Iris hypopigmentation (HP:0007730)2.45782766
61Inability to walk (HP:0002540)2.42190865
62EEG with generalized epileptiform discharges (HP:0011198)2.41890244
63Lower limb muscle weakness (HP:0007340)2.41076065
64Tetraparesis (HP:0002273)2.40305086
65Dysdiadochokinesis (HP:0002075)2.39108670
66Oligomenorrhea (HP:0000876)2.36616853
67Abnormal social behavior (HP:0012433)2.34504931
68Impaired social interactions (HP:0000735)2.34504931
69Poor suck (HP:0002033)2.34007802
70Dysmetria (HP:0001310)2.30624172
71Excessive salivation (HP:0003781)2.30074428
72Drooling (HP:0002307)2.30074428
73Acute encephalopathy (HP:0006846)2.26369768
74Mutism (HP:0002300)2.26060245
75Personality changes (HP:0000751)2.25765767
76Bradykinesia (HP:0002067)2.25572888
77Hypsarrhythmia (HP:0002521)2.24481460
78Delusions (HP:0000746)2.24449637
79Action tremor (HP:0002345)2.24084196
80Increased cerebral lipofuscin (HP:0011813)2.23510749
81Cerebral inclusion bodies (HP:0100314)2.18638520
82Increased CSF lactate (HP:0002490)2.18582697
83Status epilepticus (HP:0002133)2.18142901
84Generalized myoclonic seizures (HP:0002123)2.16967901
85Ankle clonus (HP:0011448)2.16247013
86Impaired smooth pursuit (HP:0007772)2.15599490
87Urinary bladder sphincter dysfunction (HP:0002839)2.13969142
88Neuronal loss in central nervous system (HP:0002529)2.13884862
89Spastic tetraparesis (HP:0001285)2.11427206
90Limb dystonia (HP:0002451)2.11320501
91Diminished movement (HP:0002374)2.11249832
92Hepatocellular necrosis (HP:0001404)2.10805723
93Increased serum pyruvate (HP:0003542)2.10497410
94Abnormality of glycolysis (HP:0004366)2.10497410
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07165234
96Abnormality of polysaccharide metabolism (HP:0011012)2.07165234
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07165234
98Insidious onset (HP:0003587)2.07153039
99Termporal pattern (HP:0011008)2.07153039
100Global brain atrophy (HP:0002283)2.06724687
101Protruding tongue (HP:0010808)2.06383494
102Urinary glycosaminoglycan excretion (HP:0003541)2.06076037
103Mucopolysacchariduria (HP:0008155)2.06076037
104Neurofibrillary tangles (HP:0002185)2.05511221
105Degeneration of anterior horn cells (HP:0002398)2.03012450
106Abnormality of the anterior horn cell (HP:0006802)2.03012450
107Akinesia (HP:0002304)2.02741186
108Postural tremor (HP:0002174)2.02541172
109Urinary incontinence (HP:0000020)2.00810806
110Psychosis (HP:0000709)2.00454961
111Cutaneous melanoma (HP:0012056)2.00374267
112Nuclear cataract (HP:0100018)2.00129088
113Dementia (HP:0000726)1.99840862
114Increased neuronal autofluorescent lipopigment (HP:0002074)1.99248846
115Fetal akinesia sequence (HP:0001989)1.98573547
116Specific learning disability (HP:0001328)1.98117279
117Postural instability (HP:0002172)1.97885533
118Abnormality of the periventricular white matter (HP:0002518)1.97697828
119Poor coordination (HP:0002370)1.97447156
120Scanning speech (HP:0002168)1.97080098
121Abnormality of glycolipid metabolism (HP:0010969)1.96691538
122Abnormality of liposaccharide metabolism (HP:0010968)1.96691538
123Abnormality of glycosphingolipid metabolism (HP:0004343)1.96691538
124Papilledema (HP:0001085)1.96412291
125Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95762056
126Esotropia (HP:0000565)1.94991424
127Hemiparesis (HP:0001269)1.94938070
128Spinal muscular atrophy (HP:0007269)1.94463971
129Thyroid carcinoma (HP:0002890)1.93763187
130Generalized hypopigmentation (HP:0007513)1.92881513
131Blue irides (HP:0000635)1.92333527
132Absent speech (HP:0001344)1.92178384
133Vaginal atresia (HP:0000148)1.91676888
134Dysmetric saccades (HP:0000641)1.91512684
135Rigidity (HP:0002063)1.91225762
136Genital tract atresia (HP:0001827)1.91080367
137Heterochromia iridis (HP:0001100)1.90732618
138Abnormality of the labia minora (HP:0012880)1.90698836
139Impaired vibratory sensation (HP:0002495)1.89681477
140Progressive neurologic deterioration (HP:0002344)1.89663089
141Neoplasm of the peripheral nervous system (HP:0100007)1.89643760
142Cholecystitis (HP:0001082)1.89327433
143Abnormal gallbladder physiology (HP:0012438)1.89327433
144Spastic gait (HP:0002064)1.88126395
145Abnormality of ocular smooth pursuit (HP:0000617)1.87371186
146Clonus (HP:0002169)1.86072697
147Gait ataxia (HP:0002066)1.85335964
148Autoamputation (HP:0001218)1.84660551
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.84656051
150Unsteady gait (HP:0002317)1.84309217
151Choreoathetosis (HP:0001266)1.84011990
152Rapidly progressive (HP:0003678)1.83628950
153Hyperthyroidism (HP:0000836)1.83370222
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81833098
155Sensorimotor neuropathy (HP:0007141)1.80700616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.44278376
2NTRK34.03658258
3MAP3K123.68065746
4EPHA43.27089497
5MAP3K93.16233650
6MAP3K42.97091545
7MAP2K72.94920544
8EIF2AK12.94687884
9RIPK42.88405391
10EIF2AK32.68933992
11ARAF2.65405871
12TRIM282.52006524
13PLK22.40736797
14LATS22.32256650
15DAPK22.25799757
16CDK192.25762261
17MINK12.07747059
18DAPK12.07337651
19AKT31.98963088
20GRK51.97935167
21ERBB31.95485120
22MAP2K41.88931334
23KSR21.86236201
24CAMKK21.84574402
25IRAK31.81764848
26CCNB11.68223147
27LIMK11.67480859
28MST41.67010382
29TSSK61.59881759
30PRPF4B1.57950514
31OXSR11.46762868
32MARK11.45721055
33BMPR21.45535018
34PAK61.45292317
35BRAF1.40804881
36MST1R1.40654753
37PNCK1.38840050
38MAP3K131.37828080
39NTRK11.37552164
40NME11.36333972
41MAP3K141.31432351
42ACVR1B1.31185999
43PRKCG1.29216880
44PBK1.29082292
45PDK31.28728457
46PDK41.28728457
47TESK11.23722878
48KSR11.22638391
49CAMKK11.22337658
50CDK51.19067258
51FRK1.17267445
52ALK1.11305869
53NTRK21.10300160
54CAMK2A1.08805419
55FES1.06827651
56PDK21.05050759
57MAP3K21.02250178
58CAMK2B0.95846445
59PTK2B0.91340290
60RAF10.91321243
61GRK70.87835278
62CSNK1A1L0.85371803
63SGK4940.82231927
64SGK2230.82231927
65STK38L0.81968447
66PRKCE0.81460224
67CDK140.80587112
68CDK180.80113796
69PAK40.79168465
70PRKD30.78739266
71YES10.77864120
72SGK20.75679986
73CDK150.74434712
74ABL20.74039536
75MAPK130.72849699
76WNK30.71969695
77FGR0.71375661
78CSNK1G30.69457912
79SIK30.68230850
80CSNK1G10.67886258
81TNIK0.65054111
82ADRBK20.64371462
83CAMK2D0.62124277
84MOS0.61916448
85MAP3K50.61706297
86MAP3K10.61554564
87CDK11A0.61364689
88TGFBR20.60445945
89STK390.60337546
90STK380.60309688
91NEK10.59122366
92DAPK30.58985779
93CAMK2G0.55965983
94BRSK10.55830470
95PDPK10.55289836
96PDK10.54206667
97JAK10.52226720
98MAP2K10.52150010
99SCYL20.51497396
100FER0.51219167
101BCR0.47764208
102CDK60.47133711
103CAMK10.46694571
104ERBB40.46685586
105SGK10.46502537
106ADRBK10.45754242
107UHMK10.44949680
108PRKCH0.44800952
109MET0.43997068
110CSNK1G20.43673437
111EIF2AK20.43269561
112STK160.42743481
113PDGFRA0.41871038
114MAPK100.41006193
115PINK10.40228773
116RET0.40036870
117DYRK1A0.39868231
118SGK30.39777935
119PTK20.39581933
120RIPK10.35159462
121SIK20.34273610
122PAK30.33891368
123NME20.33621585
124STK110.32875896
125PLK30.32530420
126BMPR1B0.31150786
127MYLK0.31033160
128SYK0.30404567
129PRKACA0.29681591
130PRKCA0.29644648
131CDK80.29432296
132TNK20.28526913
133RPS6KA30.26651830
134CSNK1A10.24282571
135PRKCB0.23327021
136NEK60.23287382

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047214.53852046
2* Collecting duct acid secretion_Homo sapiens_hsa049663.98697875
3Nicotine addiction_Homo sapiens_hsa050333.97583113
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68366549
5GABAergic synapse_Homo sapiens_hsa047272.57277736
6* Vibrio cholerae infection_Homo sapiens_hsa051102.52669519
7Long-term potentiation_Homo sapiens_hsa047202.44248200
8* Oxidative phosphorylation_Homo sapiens_hsa001902.39181519
9Morphine addiction_Homo sapiens_hsa050322.35014497
10Olfactory transduction_Homo sapiens_hsa047402.33319445
11Amphetamine addiction_Homo sapiens_hsa050312.31691661
12Circadian entrainment_Homo sapiens_hsa047132.27440032
13Glutamatergic synapse_Homo sapiens_hsa047242.04638236
14Dopaminergic synapse_Homo sapiens_hsa047281.94218543
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93124148
16Insulin secretion_Homo sapiens_hsa049111.84110026
17Taste transduction_Homo sapiens_hsa047421.77171770
18Salivary secretion_Homo sapiens_hsa049701.77059695
19* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.74730372
20Other glycan degradation_Homo sapiens_hsa005111.74154366
21Serotonergic synapse_Homo sapiens_hsa047261.63845600
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.62001981
23* Rheumatoid arthritis_Homo sapiens_hsa053231.60620102
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58834162
25Long-term depression_Homo sapiens_hsa047301.54533015
26Parkinsons disease_Homo sapiens_hsa050121.54379070
27Sphingolipid metabolism_Homo sapiens_hsa006001.52153091
28Alzheimers disease_Homo sapiens_hsa050101.50136946
29Protein export_Homo sapiens_hsa030601.49094104
30Renin secretion_Homo sapiens_hsa049241.45326751
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44989120
32Cholinergic synapse_Homo sapiens_hsa047251.42621214
33Gastric acid secretion_Homo sapiens_hsa049711.39645966
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37016957
35Calcium signaling pathway_Homo sapiens_hsa040201.34827172
36Cocaine addiction_Homo sapiens_hsa050301.32063894
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27592998
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24246180
39* Phagosome_Homo sapiens_hsa041451.23410240
40Type I diabetes mellitus_Homo sapiens_hsa049401.22050257
41Oxytocin signaling pathway_Homo sapiens_hsa049211.21901640
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21092614
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16762169
44Cardiac muscle contraction_Homo sapiens_hsa042601.12125958
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10715242
46Huntingtons disease_Homo sapiens_hsa050161.09560173
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08429454
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98043213
49GnRH signaling pathway_Homo sapiens_hsa049120.97096655
50Lysosome_Homo sapiens_hsa041420.97050648
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94543181
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94282543
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92472221
54Gap junction_Homo sapiens_hsa045400.88968212
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87700089
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86460269
57Phototransduction_Homo sapiens_hsa047440.86090477
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85065222
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84180694
60Regulation of autophagy_Homo sapiens_hsa041400.83989244
61Type II diabetes mellitus_Homo sapiens_hsa049300.83658375
62cAMP signaling pathway_Homo sapiens_hsa040240.83602643
63Legionellosis_Homo sapiens_hsa051340.83235432
64Folate biosynthesis_Homo sapiens_hsa007900.81748391
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81186203
66Fatty acid biosynthesis_Homo sapiens_hsa000610.77992221
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77550505
68Shigellosis_Homo sapiens_hsa051310.77333907
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74634295
70Estrogen signaling pathway_Homo sapiens_hsa049150.74523946
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.74221215
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73671156
73Oocyte meiosis_Homo sapiens_hsa041140.68388883
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.68196374
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66276697
76Glioma_Homo sapiens_hsa052140.61811276
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58409907
78Proteasome_Homo sapiens_hsa030500.58055325
79ErbB signaling pathway_Homo sapiens_hsa040120.57283700
80Pancreatic secretion_Homo sapiens_hsa049720.56797107
81Fatty acid metabolism_Homo sapiens_hsa012120.52620245
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52548167
83Melanogenesis_Homo sapiens_hsa049160.52370489
84Thyroid hormone synthesis_Homo sapiens_hsa049180.51995638
85beta-Alanine metabolism_Homo sapiens_hsa004100.51644805
86Renal cell carcinoma_Homo sapiens_hsa052110.51432124
87Tuberculosis_Homo sapiens_hsa051520.51010746
88Fatty acid elongation_Homo sapiens_hsa000620.50814733
89Inositol phosphate metabolism_Homo sapiens_hsa005620.47972392
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46762166
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44550553
92Pyruvate metabolism_Homo sapiens_hsa006200.43514772
93MAPK signaling pathway_Homo sapiens_hsa040100.42412260
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42020584
95Endocytosis_Homo sapiens_hsa041440.40754482
96Glucagon signaling pathway_Homo sapiens_hsa049220.40102641
97Vitamin B6 metabolism_Homo sapiens_hsa007500.39628752
98Pertussis_Homo sapiens_hsa051330.39153874
99Prion diseases_Homo sapiens_hsa050200.39053694
100Sulfur metabolism_Homo sapiens_hsa009200.37999442
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37485015
102Fructose and mannose metabolism_Homo sapiens_hsa000510.37034993
103African trypanosomiasis_Homo sapiens_hsa051430.35687306
104Proteoglycans in cancer_Homo sapiens_hsa052050.35146477
105Circadian rhythm_Homo sapiens_hsa047100.34315897
106Insulin signaling pathway_Homo sapiens_hsa049100.32551739
107Carbon metabolism_Homo sapiens_hsa012000.32521568
108Osteoclast differentiation_Homo sapiens_hsa043800.31959018
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.31276376
110Ras signaling pathway_Homo sapiens_hsa040140.31122249
111Axon guidance_Homo sapiens_hsa043600.30707540
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.30597303
113Alcoholism_Homo sapiens_hsa050340.30495406
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28867276
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27165541
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.26827036
117Dorso-ventral axis formation_Homo sapiens_hsa043200.26757173
118Choline metabolism in cancer_Homo sapiens_hsa052310.26299713
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25619767
120Mineral absorption_Homo sapiens_hsa049780.23433330
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22342360
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19948657
123Dilated cardiomyopathy_Homo sapiens_hsa054140.19937834
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.19568507
125Chemokine signaling pathway_Homo sapiens_hsa040620.17990211
126Salmonella infection_Homo sapiens_hsa051320.17413096
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15822266
128mTOR signaling pathway_Homo sapiens_hsa041500.14960720

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