ATP6V1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.43186041
2vocalization behavior (GO:0071625)4.76881519
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.76580211
4neuron cell-cell adhesion (GO:0007158)4.74452290
5energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.71625615
6ATP hydrolysis coupled proton transport (GO:0015991)4.71625615
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.62773833
8neuronal action potential propagation (GO:0019227)4.53298090
9protein localization to synapse (GO:0035418)4.51267121
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45062993
11glutamate secretion (GO:0014047)4.42734773
12regulation of synaptic vesicle exocytosis (GO:2000300)4.37987757
13regulation of glutamate receptor signaling pathway (GO:1900449)4.24257713
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23604013
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23602895
16gamma-aminobutyric acid signaling pathway (GO:0007214)4.21579983
17presynaptic membrane assembly (GO:0097105)4.14359220
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.12303680
19* transferrin transport (GO:0033572)4.11231713
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09068517
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.07204741
22neuron-neuron synaptic transmission (GO:0007270)4.00433468
23glutamate receptor signaling pathway (GO:0007215)3.97070272
24respiratory chain complex IV assembly (GO:0008535)3.95957971
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95896928
26regulation of synaptic vesicle transport (GO:1902803)3.93946692
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.93927665
28regulation of glutamate secretion (GO:0014048)3.90606720
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89202756
30ATP synthesis coupled proton transport (GO:0015986)3.89202756
31presynaptic membrane organization (GO:0097090)3.86541648
32response to histamine (GO:0034776)3.83770552
33protein complex biogenesis (GO:0070271)3.82945947
34* trivalent inorganic cation transport (GO:0072512)3.80684245
35* ferric iron transport (GO:0015682)3.80684245
36synaptic transmission, glutamatergic (GO:0035249)3.72628311
37proteasome assembly (GO:0043248)3.72439698
38long-term synaptic potentiation (GO:0060291)3.71520999
39neurotransmitter secretion (GO:0007269)3.66252783
40respiratory electron transport chain (GO:0022904)3.58461561
41protein neddylation (GO:0045116)3.51161229
42electron transport chain (GO:0022900)3.51018256
43behavioral response to cocaine (GO:0048148)3.49053690
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48803715
45synaptic vesicle maturation (GO:0016188)3.48796781
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48499433
47neurotransmitter-gated ion channel clustering (GO:0072578)3.48354075
48mitochondrial respiratory chain complex assembly (GO:0033108)3.48191028
49locomotory exploration behavior (GO:0035641)3.47964212
50negative regulation of amino acid transport (GO:0051956)3.40550132
51cytochrome complex assembly (GO:0017004)3.38536337
52platelet dense granule organization (GO:0060155)3.37162303
53* phagosome maturation (GO:0090382)3.36715191
54regulation of postsynaptic membrane potential (GO:0060078)3.34077727
55postsynaptic membrane organization (GO:0001941)3.32139610
56synaptic transmission, dopaminergic (GO:0001963)3.29110524
57regulation of neuronal synaptic plasticity (GO:0048168)3.27491028
58chaperone-mediated protein transport (GO:0072321)3.27481974
59detection of calcium ion (GO:0005513)3.25913554
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.23703735
61NADH dehydrogenase complex assembly (GO:0010257)3.23703735
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23703735
63neuron recognition (GO:0008038)3.22756181
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22250555
65positive regulation of membrane potential (GO:0045838)3.22086722
66synaptic vesicle endocytosis (GO:0048488)3.21849961
67exploration behavior (GO:0035640)3.21507696
68neurotransmitter transport (GO:0006836)3.19659350
69positive regulation of neurotransmitter transport (GO:0051590)3.18990710
70regulation of protein kinase A signaling (GO:0010738)3.18209822
71regulation of vesicle fusion (GO:0031338)3.18139118
72positive regulation of neurotransmitter secretion (GO:0001956)3.17502862
73startle response (GO:0001964)3.16501274
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16431398
75regulation of synaptic plasticity (GO:0048167)3.15057632
76negative regulation of dendrite morphogenesis (GO:0050774)3.10158814
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10083689
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.09120920
79regulation of neurotransmitter secretion (GO:0046928)3.07142278
80transmission of nerve impulse (GO:0019226)3.06690410
81hydrogen ion transmembrane transport (GO:1902600)3.03494825
82regulation of voltage-gated calcium channel activity (GO:1901385)3.01709615
83long-term memory (GO:0007616)3.00977969
84behavioral defense response (GO:0002209)3.00366799
85behavioral fear response (GO:0001662)3.00366799
86positive regulation of synapse assembly (GO:0051965)3.00057518
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98656550
88female mating behavior (GO:0060180)2.98126079
89cullin deneddylation (GO:0010388)2.96875147
90establishment of protein localization to mitochondrial membrane (GO:0090151)2.96575558
91fear response (GO:0042596)2.94315944
92regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.94200566
93regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.94200566
94establishment of synaptic vesicle localization (GO:0097480)2.93581955
95synaptic vesicle transport (GO:0048489)2.93581955
96* proton transport (GO:0015992)2.91502702
97regulation of neurotransmitter levels (GO:0001505)2.89270875
98regulation of dopamine metabolic process (GO:0042053)2.87595318
99regulation of catecholamine metabolic process (GO:0042069)2.87595318
100regulation of neurotransmitter transport (GO:0051588)2.86765567
101synaptic transmission (GO:0007268)2.86373767
102* hydrogen transport (GO:0006818)2.86366281
103regulation of glucokinase activity (GO:0033131)2.85459845
104regulation of hexokinase activity (GO:1903299)2.85459845
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85156227
106positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84629916
107membrane depolarization (GO:0051899)2.84352535
108dopamine transport (GO:0015872)2.84147677
109striatum development (GO:0021756)2.83866645
110water-soluble vitamin biosynthetic process (GO:0042364)2.81201981
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.80754489
112positive regulation of synaptic transmission (GO:0050806)2.80078958
113proline transport (GO:0015824)2.77314288
114long term synaptic depression (GO:0060292)2.77005410
115regulation of synapse structural plasticity (GO:0051823)2.76269053
116positive regulation of synapse maturation (GO:0090129)2.76165827
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.76048841
118signal peptide processing (GO:0006465)2.75778506
119epithelial cilium movement (GO:0003351)2.72536496
120regulation of cilium movement (GO:0003352)2.70710369
121protein deneddylation (GO:0000338)2.66983052
122negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62723358
123heart process (GO:0003015)2.56205637
124heart contraction (GO:0060047)2.56205637
125behavioral response to nicotine (GO:0035095)2.54444604
126nonmotile primary cilium assembly (GO:0035058)2.51878289
127regulation of cellular amino acid metabolic process (GO:0006521)2.49702760
128glycerophospholipid catabolic process (GO:0046475)2.48131154
129cilium morphogenesis (GO:0060271)2.42645205
130righting reflex (GO:0060013)2.41972834
131ATP biosynthetic process (GO:0006754)2.41611621
132anterograde synaptic vesicle transport (GO:0048490)2.40053656
133positive regulation of meiosis (GO:0045836)2.38283454
134negative regulation of cation channel activity (GO:2001258)2.38228809
135establishment of melanosome localization (GO:0032401)2.37935392
136intraciliary transport (GO:0042073)2.37008289
137positive regulation of actin filament depolymerization (GO:0030836)2.36725952
138melanosome transport (GO:0032402)2.36252845
139regulation of oxidative phosphorylation (GO:0002082)2.35924545
140dopamine biosynthetic process (GO:0042416)2.35662942
141anterograde axon cargo transport (GO:0008089)2.34192027
142cellular ketone body metabolic process (GO:0046950)2.33023849
143retinal cone cell development (GO:0046549)2.32838773
144inositol phosphate catabolic process (GO:0071545)2.31986979
145magnesium ion transport (GO:0015693)2.31984743
146positive regulation of protein autophosphorylation (GO:0031954)2.30736283
147regulation of cell communication by electrical coupling (GO:0010649)2.30214487
148lipid particle organization (GO:0034389)2.30032144
149substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.29187783
150substrate-independent telencephalic tangential migration (GO:0021826)2.29187783
151positive regulation of meiotic cell cycle (GO:0051446)2.28424271
152protein-cofactor linkage (GO:0018065)2.27044317
153regulation of neurotransmitter uptake (GO:0051580)2.26497532
154organelle disassembly (GO:1903008)2.25659123
155lactate metabolic process (GO:0006089)2.25386633
156establishment of pigment granule localization (GO:0051905)2.25354123
157axoneme assembly (GO:0035082)2.24333533
158pigment granule transport (GO:0051904)2.23176180
159regulation of meiosis I (GO:0060631)2.22564621
160purine nucleoside triphosphate biosynthetic process (GO:0009145)2.22275913
161regulation of type B pancreatic cell apoptotic process (GO:2000674)2.21914218
162cilium movement (GO:0003341)2.21225873
163response to amphetamine (GO:0001975)2.21102926
164regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.21099375
165peptidyl-cysteine modification (GO:0018198)2.20697468
166ketone body metabolic process (GO:1902224)2.20674687
167C-terminal protein amino acid modification (GO:0018410)2.18641474
168glutathione derivative metabolic process (GO:1901685)2.18565599
169glutathione derivative biosynthetic process (GO:1901687)2.18565599
170purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.17400267
171xenobiotic catabolic process (GO:0042178)2.17370423
172insulin secretion (GO:0030073)2.17216129
173peroxisome fission (GO:0016559)2.16907170
174DNA double-strand break processing (GO:0000729)2.16750634
175neurofilament cytoskeleton organization (GO:0060052)2.15765752
176positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.15517013
177C-terminal protein lipidation (GO:0006501)2.14401849
178aldehyde catabolic process (GO:0046185)2.14038924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39429705
2GBX2_23144817_ChIP-Seq_PC3_Human4.40548840
3TAF15_26573619_Chip-Seq_HEK293_Human3.14486873
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03378354
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81773461
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77942394
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56073906
8REST_21632747_ChIP-Seq_MESCs_Mouse2.54280722
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50130529
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47368640
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44257144
12* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43356274
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39394038
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.34538069
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34162177
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32394928
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27683280
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.26438697
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25963281
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25963281
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24409123
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20044764
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17547600
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15978796
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.08831937
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08085372
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.05155390
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.02768764
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99601316
30* P300_19829295_ChIP-Seq_ESCs_Human1.96941336
31VDR_22108803_ChIP-Seq_LS180_Human1.92712660
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.92689185
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89242043
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88638557
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87672237
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85460344
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85347087
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.79200052
39FUS_26573619_Chip-Seq_HEK293_Human1.78692105
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.76575923
41* EST1_17652178_ChIP-ChIP_JURKAT_Human1.75283703
42ELK1_19687146_ChIP-ChIP_HELA_Human1.64402815
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63829128
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59649350
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53999759
46AR_21572438_ChIP-Seq_LNCaP_Human1.52886908
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.51504654
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51105842
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50546669
50DROSHA_22980978_ChIP-Seq_HELA_Human1.49952457
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.49153631
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48031837
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47413411
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46737374
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45863177
56AR_25329375_ChIP-Seq_VCAP_Human1.44849884
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43659139
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43525157
59ER_23166858_ChIP-Seq_MCF-7_Human1.43029448
60ZNF274_21170338_ChIP-Seq_K562_Hela1.42618031
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42471888
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.40005918
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.38072223
64SOX2_19829295_ChIP-Seq_ESCs_Human1.37517473
65NANOG_19829295_ChIP-Seq_ESCs_Human1.37517473
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36643893
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.35354437
68RNF2_27304074_Chip-Seq_NSC_Mouse1.35071847
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33571697
70HTT_18923047_ChIP-ChIP_STHdh_Human1.33253882
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.30568618
72IGF1R_20145208_ChIP-Seq_DFB_Human1.28360262
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25924679
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25449618
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.22348692
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.21656586
77JUN_21703547_ChIP-Seq_K562_Human1.20729188
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20692328
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.19815720
80* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19656747
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18698785
82TP53_22573176_ChIP-Seq_HFKS_Human1.18148548
83TCF4_22108803_ChIP-Seq_LS180_Human1.17769940
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17645419
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.17293372
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.16640285
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15958205
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15958205
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15839761
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15506858
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.14796033
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13915537
93RUNX2_22187159_ChIP-Seq_PCA_Human1.11695433
94STAT3_23295773_ChIP-Seq_U87_Human1.11649149
95P300_18555785_Chip-Seq_ESCs_Mouse1.11323216
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10757400
97* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10755136
98* CDX2_22108803_ChIP-Seq_LS180_Human1.10550415
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.10062657
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.09861270
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09861270
102TCF4_23295773_ChIP-Seq_U87_Human1.09045958
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08180576
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08075862
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07898376
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07884448
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07231390
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06377020
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.05420766
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05134611
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05074136
112BCAT_22108803_ChIP-Seq_LS180_Human1.04918420
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04698234
114P53_22387025_ChIP-Seq_ESCs_Mouse1.03861077
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.03185443
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03021759
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01309645
118KDM2B_26808549_Chip-Seq_REH_Human1.00660376
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00246235
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00070930
121TP53_18474530_ChIP-ChIP_U2OS_Human1.00045987
122CMYC_18555785_Chip-Seq_ESCs_Mouse0.99944543
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99707779
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.99099746
125* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98530864
126NMYC_18555785_Chip-Seq_ESCs_Mouse0.98018504
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97671556
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96634464
129SOX2_18555785_Chip-Seq_ESCs_Mouse0.96575313
130CBP_20019798_ChIP-Seq_JUKART_Human0.95343119
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95343119
132EWS_26573619_Chip-Seq_HEK293_Human0.94937527
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93681267
134SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91761539
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.90733289
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.90493577
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89888416
138STAT3_18555785_Chip-Seq_ESCs_Mouse0.89824968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.10713601
2MP0004859_abnormal_synaptic_plasticity4.96050150
3MP0003635_abnormal_synaptic_transmissio3.74810695
4MP0009745_abnormal_behavioral_response3.49259827
5MP0001968_abnormal_touch/_nociception3.30994884
6MP0002064_seizures3.28208040
7MP0009046_muscle_twitch3.16369046
8MP0002063_abnormal_learning/memory/cond3.06233340
9MP0004270_analgesia3.01975674
10MP0002736_abnormal_nociception_after3.01129061
11MP0002572_abnormal_emotion/affect_behav2.82601545
12MP0002272_abnormal_nervous_system2.61368837
13MP0001501_abnormal_sleep_pattern2.54240125
14MP0001529_abnormal_vocalization2.49832095
15MP0001440_abnormal_grooming_behavior2.45844275
16MP0002735_abnormal_chemical_nociception2.44906163
17MP0002734_abnormal_mechanical_nocicepti2.40332619
18MP0002822_catalepsy2.29633276
19MP0001486_abnormal_startle_reflex2.28558726
20MP0006276_abnormal_autonomic_nervous2.27882155
21MP0002837_dystrophic_cardiac_calcinosis2.15202150
22MP0002067_abnormal_sensory_capabilities2.06884649
23MP0001905_abnormal_dopamine_level2.04401127
24MP0003195_calcinosis2.03484595
25MP0001984_abnormal_olfaction2.00849825
26MP0005423_abnormal_somatic_nervous1.99778472
27MP0001970_abnormal_pain_threshold1.99148734
28MP0002733_abnormal_thermal_nociception1.93633507
29MP0003806_abnormal_nucleotide_metabolis1.85342219
30MP0000372_irregular_coat_pigmentation1.83582775
31MP0004924_abnormal_behavior1.83222581
32MP0005386_behavior/neurological_phenoty1.83222581
33MP0000569_abnormal_digit_pigmentation1.82755024
34MP0003011_delayed_dark_adaptation1.81003201
35MP0005646_abnormal_pituitary_gland1.80511936
36MP0002102_abnormal_ear_morphology1.77535284
37MP0003329_amyloid_beta_deposits1.67165625
38MP0003122_maternal_imprinting1.59369492
39MP0002557_abnormal_social/conspecific_i1.58114063
40MP0004142_abnormal_muscle_tone1.54779649
41MP0002184_abnormal_innervation1.54328884
42MP0003879_abnormal_hair_cell1.54324683
43MP0005253_abnormal_eye_physiology1.54121183
44MP0002876_abnormal_thyroid_physiology1.53758913
45MP0003787_abnormal_imprinting1.52188550
46MP0010386_abnormal_urinary_bladder1.49321372
47MP0008875_abnormal_xenobiotic_pharmacok1.47134628
48MP0000778_abnormal_nervous_system1.45224218
49MP0001188_hyperpigmentation1.44967412
50MP0005084_abnormal_gallbladder_morpholo1.39730893
51MP0008569_lethality_at_weaning1.33768970
52MP0003186_abnormal_redox_activity1.33162597
53MP0002066_abnormal_motor_capabilities/c1.30499643
54MP0003950_abnormal_plasma_membrane1.30416326
55MP0009780_abnormal_chondrocyte_physiolo1.29128044
56MP0004811_abnormal_neuron_physiology1.28975097
57MP0003283_abnormal_digestive_organ1.27536290
58MP0003136_yellow_coat_color1.25603864
59MP0003718_maternal_effect1.23556057
60MP0001502_abnormal_circadian_rhythm1.23305661
61MP0002938_white_spotting1.22906079
62MP0001756_abnormal_urination1.18422038
63MP0006054_spinal_hemorrhage1.18015359
64MP0000647_abnormal_sebaceous_gland1.17776318
65MP0002882_abnormal_neuron_morphology1.17706152
66MP0005171_absent_coat_pigmentation1.17162021
67MP0003121_genomic_imprinting1.16620783
68MP0002909_abnormal_adrenal_gland1.15864686
69MP0003890_abnormal_embryonic-extraembry1.13036995
70MP0000955_abnormal_spinal_cord1.11970995
71MP0004147_increased_porphyrin_level1.11526068
72MP0004742_abnormal_vestibular_system1.10114591
73MP0005645_abnormal_hypothalamus_physiol1.09703229
74MP0000751_myopathy1.08911394
75MP0003633_abnormal_nervous_system1.07893094
76MP0002234_abnormal_pharynx_morphology1.07852962
77MP0008872_abnormal_physiological_respon1.04776791
78MP0005535_abnormal_body_temperature1.04659588
79MP0004145_abnormal_muscle_electrophysio1.04535969
80MP0000013_abnormal_adipose_tissue1.04493691
81MP0001963_abnormal_hearing_physiology1.03044329
82MP0005332_abnormal_amino_acid1.01643574
83MP0004858_abnormal_nervous_system0.99150060
84MP0004019_abnormal_vitamin_homeostasis0.98963726
85MP0002163_abnormal_gland_morphology0.98342246
86MP0003137_abnormal_impulse_conducting0.96998905
87MP0003646_muscle_fatigue0.96744630
88MP0002295_abnormal_pulmonary_circulatio0.96676093
89MP0002229_neurodegeneration0.95767891
90MP0005551_abnormal_eye_electrophysiolog0.95487069
91MP0004885_abnormal_endolymph0.94964487
92MP0003631_nervous_system_phenotype0.91934130
93MP0002139_abnormal_hepatobiliary_system0.91205331
94MP0005379_endocrine/exocrine_gland_phen0.91157860
95MP0000516_abnormal_urinary_system0.91026016
96MP0005367_renal/urinary_system_phenotyp0.91026016
97MP0003941_abnormal_skin_development0.90960696
98MP0000427_abnormal_hair_cycle0.90820144
99MP0004133_heterotaxia0.89837376
100MP0001944_abnormal_pancreas_morphology0.88828795
101MP0004484_altered_response_of0.87754878
102MP0000604_amyloidosis0.85423447
103MP0002638_abnormal_pupillary_reflex0.84042694
104MP0005174_abnormal_tail_pigmentation0.83336234
105MP0002069_abnormal_eating/drinking_beha0.83126973
106MP0004043_abnormal_pH_regulation0.83001456
107MP0008789_abnormal_olfactory_epithelium0.82805804
108MP0008874_decreased_physiological_sensi0.82260504
109MP0002090_abnormal_vision0.81852807
110MP0005499_abnormal_olfactory_system0.80969576
111MP0005394_taste/olfaction_phenotype0.80969576
112MP0001986_abnormal_taste_sensitivity0.80307893
113MP0004510_myositis0.80163235
114MP0002160_abnormal_reproductive_system0.77994908
115MP0000639_abnormal_adrenal_gland0.77938745
116MP0002152_abnormal_brain_morphology0.76774573
117MP0006035_abnormal_mitochondrial_morpho0.75686210
118MP0002693_abnormal_pancreas_physiology0.75433070
119MP0005409_darkened_coat_color0.73517528
120MP0004085_abnormal_heartbeat0.72845971
121MP0001664_abnormal_digestion0.72124230
122MP0004215_abnormal_myocardial_fiber0.71271424
123MP0002752_abnormal_somatic_nervous0.70410800
124MP0004036_abnormal_muscle_relaxation0.69780256
125MP0000631_abnormal_neuroendocrine_gland0.69759551
126MP0002332_abnormal_exercise_endurance0.68559186
127MP0001485_abnormal_pinna_reflex0.67350735
128MP0003634_abnormal_glial_cell0.66586732
129MP0006072_abnormal_retinal_apoptosis0.64300361
130MP0000026_abnormal_inner_ear0.60894989
131MP0008877_abnormal_DNA_methylation0.60322444
132MP0000920_abnormal_myelination0.59210519
133MP0001765_abnormal_ion_homeostasis0.57618644
134MP0005410_abnormal_fertilization0.57603916
135MP0003183_abnormal_peptide_metabolism0.57009679
136MP0005310_abnormal_salivary_gland0.55841823
137MP0000015_abnormal_ear_pigmentation0.55792201
138MP0006036_abnormal_mitochondrial_physio0.55288903

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.78724827
2Atonic seizures (HP:0010819)5.29300284
3Myokymia (HP:0002411)5.19678313
4Focal seizures (HP:0007359)4.99677308
5Acute necrotizing encephalopathy (HP:0006965)4.88325623
6Epileptic encephalopathy (HP:0200134)4.84020667
7Abnormal mitochondria in muscle tissue (HP:0008316)4.48070767
8Visual hallucinations (HP:0002367)4.47625480
9Febrile seizures (HP:0002373)4.46121240
10Absence seizures (HP:0002121)4.35325081
11Progressive macrocephaly (HP:0004481)4.30869160
12Dialeptic seizures (HP:0011146)4.13953557
13Hyperventilation (HP:0002883)4.04353831
14Mitochondrial inheritance (HP:0001427)3.93629393
15Acute encephalopathy (HP:0006846)3.64803609
16Generalized tonic-clonic seizures (HP:0002069)3.62749029
17Increased CSF lactate (HP:0002490)3.36279131
18Progressive cerebellar ataxia (HP:0002073)3.32567831
19Pheochromocytoma (HP:0002666)3.21018018
20Neuroendocrine neoplasm (HP:0100634)3.15771647
21Broad-based gait (HP:0002136)3.09120406
22Gait imbalance (HP:0002141)3.08779348
23Medial flaring of the eyebrow (HP:0010747)3.05004557
24Amblyopia (HP:0000646)3.03189116
25Hepatocellular necrosis (HP:0001404)2.96637442
26Congenital primary aphakia (HP:0007707)2.92102447
27Abnormal hair whorl (HP:0010721)2.86086680
28Nephrogenic diabetes insipidus (HP:0009806)2.78029717
29Methylmalonic acidemia (HP:0002912)2.76923444
303-Methylglutaconic aciduria (HP:0003535)2.76027638
31Optic disc pallor (HP:0000543)2.74737713
32Progressive inability to walk (HP:0002505)2.71097875
33Anxiety (HP:0000739)2.68557069
34Pancreatic fibrosis (HP:0100732)2.68120747
35Polyphagia (HP:0002591)2.64285632
36Abnormality of midbrain morphology (HP:0002418)2.61697752
37Molar tooth sign on MRI (HP:0002419)2.61697752
38Abnormal eating behavior (HP:0100738)2.59467684
39Hypoglycemic coma (HP:0001325)2.56640639
40Gaze-evoked nystagmus (HP:0000640)2.55887402
41True hermaphroditism (HP:0010459)2.55059254
42Inability to walk (HP:0002540)2.54908699
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50740117
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50740117
45Hypokinesia (HP:0002375)2.48402059
46Limb dystonia (HP:0002451)2.47212303
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45452522
48Delusions (HP:0000746)2.44596515
49Supranuclear gaze palsy (HP:0000605)2.40953650
50Pancreatic cysts (HP:0001737)2.40117535
51Truncal ataxia (HP:0002078)2.37059486
52Leukodystrophy (HP:0002415)2.36998716
53Cerebral inclusion bodies (HP:0100314)2.35511854
54Increased hepatocellular lipid droplets (HP:0006565)2.33553664
55Congenital, generalized hypertrichosis (HP:0004540)2.33304084
56Delayed gross motor development (HP:0002194)2.31393165
57Absent/shortened dynein arms (HP:0200106)2.30957413
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.30957413
59Epileptiform EEG discharges (HP:0011182)2.30731163
60Respiratory failure (HP:0002878)2.30109838
61Genital tract atresia (HP:0001827)2.29107628
62Poor eye contact (HP:0000817)2.27515817
63Increased serum pyruvate (HP:0003542)2.24539073
64Abnormality of glycolysis (HP:0004366)2.24539073
65Exertional dyspnea (HP:0002875)2.24311520
66Hyperinsulinemic hypoglycemia (HP:0000825)2.24271117
67Vaginal atresia (HP:0000148)2.24176513
68Glycosuria (HP:0003076)2.24091236
69Abnormality of urine glucose concentration (HP:0011016)2.24091236
70Fetal akinesia sequence (HP:0001989)2.20665409
71Abnormality of binocular vision (HP:0011514)2.19088199
72Diplopia (HP:0000651)2.19088199
73Cerebral edema (HP:0002181)2.18938669
74Impaired vibration sensation in the lower limbs (HP:0002166)2.17972483
75Large for gestational age (HP:0001520)2.15866601
76Degeneration of anterior horn cells (HP:0002398)2.15627698
77Abnormality of the anterior horn cell (HP:0006802)2.15627698
78Dysmetria (HP:0001310)2.15118153
79Exercise intolerance (HP:0003546)2.14112752
80Generalized aminoaciduria (HP:0002909)2.11963027
81Hypothermia (HP:0002045)2.11845930
82X-linked dominant inheritance (HP:0001423)2.09737856
83Abnormality of renal resorption (HP:0011038)2.09584272
84Intestinal atresia (HP:0011100)2.09521313
85Neurofibrillary tangles (HP:0002185)2.09096284
86Depression (HP:0000716)2.08243944
87Drooling (HP:0002307)2.08076208
88Excessive salivation (HP:0003781)2.08076208
89Methylmalonic aciduria (HP:0012120)2.08035397
90Poor coordination (HP:0002370)2.07891861
91EEG with generalized epileptiform discharges (HP:0011198)2.04596383
92Renal Fanconi syndrome (HP:0001994)2.04556140
93Abnormal ciliary motility (HP:0012262)2.03679891
94Failure to thrive in infancy (HP:0001531)2.02643342
95Ketoacidosis (HP:0001993)2.02002343
96Hepatic necrosis (HP:0002605)2.01685525
97Lactic acidosis (HP:0003128)2.00107502
98Dysdiadochokinesis (HP:0002075)2.00059525
99Diminished movement (HP:0002374)1.99318583
100Absent speech (HP:0001344)1.99156862
101Esotropia (HP:0000565)1.98895875
102Rhinitis (HP:0012384)1.98788482
103Poor suck (HP:0002033)1.98671886
104Blue irides (HP:0000635)1.97913357
105Hypoglycemic seizures (HP:0002173)1.97899162
106Abnormality of vitamin B metabolism (HP:0004340)1.97800234
107Aplasia/Hypoplasia of the fovea (HP:0008060)1.96596876
108Hypoplasia of the fovea (HP:0007750)1.96596876
109Muscular hypotonia of the trunk (HP:0008936)1.95625292
110Psychosis (HP:0000709)1.95217551
111Nephronophthisis (HP:0000090)1.93639148
112Impaired social interactions (HP:0000735)1.92784261
113Abnormal social behavior (HP:0012433)1.92784261
114CNS demyelination (HP:0007305)1.92600757
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92070699
116Generalized myoclonic seizures (HP:0002123)1.92044098
117Specific learning disability (HP:0001328)1.91813274
118Oligomenorrhea (HP:0000876)1.90628246
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90622273
120Bradykinesia (HP:0002067)1.88360383
121Abnormality of the labia minora (HP:0012880)1.87476011
122Abnormal respiratory epithelium morphology (HP:0012253)1.86703037
123Abnormal respiratory motile cilium morphology (HP:0005938)1.86703037
124Abnormal respiratory motile cilium physiology (HP:0012261)1.85469535
125Urinary bladder sphincter dysfunction (HP:0002839)1.85014058
126Increased serum lactate (HP:0002151)1.84930139
127Hemiparesis (HP:0001269)1.84803401
128Palpitations (HP:0001962)1.83176292
129Hypsarrhythmia (HP:0002521)1.83113271
130Action tremor (HP:0002345)1.82769013
131Mutism (HP:0002300)1.81576732
132Tongue fasciculations (HP:0001308)1.81452797
133Lipid accumulation in hepatocytes (HP:0006561)1.80456468
134Furrowed tongue (HP:0000221)1.80333329
135Abnormality of glycolipid metabolism (HP:0010969)1.79854477
136Abnormality of liposaccharide metabolism (HP:0010968)1.79854477
137Abnormality of glycosphingolipid metabolism (HP:0004343)1.79854477
138Protruding tongue (HP:0010808)1.78437835
139Increased intramyocellular lipid droplets (HP:0012240)1.76401207
140Cerebral hemorrhage (HP:0001342)1.76077532
141Cholecystitis (HP:0001082)1.75919561
142Abnormal gallbladder physiology (HP:0012438)1.75919561
143Incomplete penetrance (HP:0003829)1.74321116
144Type II lissencephaly (HP:0007260)1.73803560
145Focal dystonia (HP:0004373)1.73705611
146Hypomagnesemia (HP:0002917)1.72696249
147Resting tremor (HP:0002322)1.72453390
148Abnormality of alanine metabolism (HP:0010916)1.72439334
149Hyperalaninemia (HP:0003348)1.72439334
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72439334
151Abnormality of the fovea (HP:0000493)1.70586741
152Congenital malformation of the right heart (HP:0011723)1.70106469
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69764949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.22543277
2CASK4.00016838
3NTRK33.78236364
4EPHA43.64580019
5RIPK43.35650673
6FRK3.02468780
7MAP2K72.93530685
8MAP3K42.89846716
9TRIM282.60400113
10ARAF2.56297764
11MAP3K92.50855184
12PLK22.44658014
13CDK192.26383557
14GRK52.19304041
15PNCK2.18158384
16MINK12.04870935
17STK162.04384347
18MAP2K41.97160985
19DAPK21.94464346
20ERBB31.85611509
21BMPR21.83510112
22MAP4K21.82843061
23NME11.82515640
24OXSR11.81591189
25DAPK11.81240494
26LIMK11.77768311
27STK38L1.70147193
28TNIK1.57033207
29EIF2AK11.55137996
30SIK31.54654914
31ACVR1B1.53732133
32EIF2AK31.49814982
33BCR1.45531701
34MARK11.34932429
35GRK71.32119366
36PTK2B1.28203240
37STK241.28187108
38KSR21.25811244
39CAMKK21.25550956
40GRK11.24268171
41PLK31.20541127
42MAP3K131.18595775
43PRKCG1.18185075
44AKT31.17850445
45CAMK2A1.17374914
46CSNK1G11.16544242
47CDK51.14145575
48FES1.13171502
49CCNB11.11973376
50PRPF4B1.10598290
51KSR11.08370509
52MAPK131.08064250
53CAMK2B1.03745647
54NTRK21.03606553
55NTRK11.02408008
56FGR0.99067051
57TESK10.98563228
58PAK60.97798944
59MYLK0.93053856
60PBK0.92117045
61ADRBK20.90332889
62PDK40.88983794
63PDK30.88983794
64STK30.88860659
65TSSK60.87941208
66BRAF0.85904994
67PRKCE0.82986699
68STK390.82537158
69BUB10.81935677
70MST40.81910986
71ZAK0.79734846
72INSRR0.78803833
73WNK40.78355817
74NUAK10.78210211
75SIK20.77453395
76DYRK20.77344410
77PDK20.77038091
78CAMKK10.76689598
79CDK180.75227930
80ADRBK10.75192519
81MKNK20.74964745
82NEK10.74113058
83CDK140.73838157
84CSNK1A1L0.72174671
85CDK150.66757423
86CAMK2D0.64857950
87SGK2230.64564213
88SGK4940.64564213
89MUSK0.64248874
90EPHB20.62741067
91ERBB40.62643383
92LMTK20.62188240
93ABL20.62001774
94DAPK30.60768523
95RAF10.60268868
96FER0.59114669
97CDK11A0.57967151
98FGFR20.56717061
99MAP3K20.56527428
100PINK10.56331820
101CAMK2G0.54993850
102WNK30.54096033
103CSNK1G20.53949875
104DYRK1A0.53075400
105UHMK10.52803093
106MOS0.52368176
107GRK60.52237121
108SGK20.52146161
109ROCK10.50664004
110ILK0.50458863
111PRKCI0.50329074
112MAPKAPK50.49996451
113CAMK10.48705190
114WEE10.47324760
115VRK10.47114611
116BRSK20.46464745
117SGK10.44488188
118PAK30.43832709
119PRKG10.43508246
120SYK0.42151542
121PLK10.41819836
122ROCK20.41691148
123TNK20.41523454
124MAP2K10.41445402
125OBSCN0.41434092
126BMPR1B0.41415110
127PRKACA0.39696741
128PKN10.37846769
129MAP3K10.37797650
130CSNK1A10.37205015
131PHKG10.36569892
132PHKG20.36569892
133MAPKAPK30.36228668
134TRPM70.35515688
135MAPK120.34766082
136STK380.34268136
137PDPK10.33552993
138NEK60.31502191
139PDK10.31064724
140PRKCA0.30495767
141CSNK1G30.29925554
142STK110.29211498
143FYN0.25114882

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86750281
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.73987741
3* Oxidative phosphorylation_Homo sapiens_hsa001903.68303424
4* Collecting duct acid secretion_Homo sapiens_hsa049663.60875383
5Parkinsons disease_Homo sapiens_hsa050122.80961923
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68396471
7Alzheimers disease_Homo sapiens_hsa050102.50176594
8Long-term potentiation_Homo sapiens_hsa047202.40072818
9GABAergic synapse_Homo sapiens_hsa047272.39972268
10Olfactory transduction_Homo sapiens_hsa047402.39119639
11Amphetamine addiction_Homo sapiens_hsa050312.35815664
12Morphine addiction_Homo sapiens_hsa050322.31299130
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28488408
14Circadian entrainment_Homo sapiens_hsa047132.28344606
15* Vibrio cholerae infection_Homo sapiens_hsa051102.16196276
16Glutamatergic synapse_Homo sapiens_hsa047242.06683054
17Sulfur metabolism_Homo sapiens_hsa009202.02900816
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.97588519
19Huntingtons disease_Homo sapiens_hsa050161.97144789
20Taste transduction_Homo sapiens_hsa047421.95196293
21Dopaminergic synapse_Homo sapiens_hsa047281.93116596
22Folate biosynthesis_Homo sapiens_hsa007901.91196985
23Cardiac muscle contraction_Homo sapiens_hsa042601.84442214
24Salivary secretion_Homo sapiens_hsa049701.83389139
25Serotonergic synapse_Homo sapiens_hsa047261.81039139
26Fatty acid elongation_Homo sapiens_hsa000621.75330731
27Butanoate metabolism_Homo sapiens_hsa006501.64031390
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63091008
29Renin secretion_Homo sapiens_hsa049241.62993796
30* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.57803435
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57468335
32* Rheumatoid arthritis_Homo sapiens_hsa053231.57184059
33Propanoate metabolism_Homo sapiens_hsa006401.54980697
34Insulin secretion_Homo sapiens_hsa049111.54002008
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53998211
36Calcium signaling pathway_Homo sapiens_hsa040201.51610555
37Long-term depression_Homo sapiens_hsa047301.49988032
38Gastric acid secretion_Homo sapiens_hsa049711.46670546
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44243170
40Cholinergic synapse_Homo sapiens_hsa047251.42164241
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39630616
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38651720
43Cocaine addiction_Homo sapiens_hsa050301.36069522
44Vitamin B6 metabolism_Homo sapiens_hsa007501.34517649
45Oxytocin signaling pathway_Homo sapiens_hsa049211.33507227
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33283217
47RNA polymerase_Homo sapiens_hsa030201.31434621
48Basal transcription factors_Homo sapiens_hsa030221.26788561
49Phototransduction_Homo sapiens_hsa047441.26397551
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20565104
51Tryptophan metabolism_Homo sapiens_hsa003801.19962399
52Steroid biosynthesis_Homo sapiens_hsa001001.18883515
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14306243
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14118153
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12297195
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10721096
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.05669219
58Glutathione metabolism_Homo sapiens_hsa004801.05554933
59Type I diabetes mellitus_Homo sapiens_hsa049401.05013404
60GnRH signaling pathway_Homo sapiens_hsa049121.02062747
61Gap junction_Homo sapiens_hsa045400.94549145
62Nitrogen metabolism_Homo sapiens_hsa009100.94481011
63Peroxisome_Homo sapiens_hsa041460.93519989
64beta-Alanine metabolism_Homo sapiens_hsa004100.89873070
65* Phagosome_Homo sapiens_hsa041450.87216060
66cAMP signaling pathway_Homo sapiens_hsa040240.86740761
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85332863
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81513459
69Sphingolipid metabolism_Homo sapiens_hsa006000.81201719
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78213773
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.77999930
72Ether lipid metabolism_Homo sapiens_hsa005650.77685524
73Proteasome_Homo sapiens_hsa030500.76172678
74* Metabolic pathways_Homo sapiens_hsa011000.75295581
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74449913
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74105481
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73409057
78Chemical carcinogenesis_Homo sapiens_hsa052040.72573023
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71748014
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71005405
81Selenocompound metabolism_Homo sapiens_hsa004500.70500825
82African trypanosomiasis_Homo sapiens_hsa051430.69254344
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67665976
84Estrogen signaling pathway_Homo sapiens_hsa049150.67096999
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65997579
86Melanogenesis_Homo sapiens_hsa049160.65049726
87Linoleic acid metabolism_Homo sapiens_hsa005910.63276775
88Axon guidance_Homo sapiens_hsa043600.61171917
89Pancreatic secretion_Homo sapiens_hsa049720.59295285
90RNA degradation_Homo sapiens_hsa030180.59117058
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56232379
92Purine metabolism_Homo sapiens_hsa002300.53584758
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53540871
94Fatty acid degradation_Homo sapiens_hsa000710.53439336
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53340955
96Oocyte meiosis_Homo sapiens_hsa041140.53214984
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52347146
98Caffeine metabolism_Homo sapiens_hsa002320.51416935
99Glioma_Homo sapiens_hsa052140.50910445
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50909113
101Type II diabetes mellitus_Homo sapiens_hsa049300.50503202
102ErbB signaling pathway_Homo sapiens_hsa040120.49851401
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48475625
104Fatty acid metabolism_Homo sapiens_hsa012120.48293654
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46577571
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45976050
107Arginine and proline metabolism_Homo sapiens_hsa003300.45276430
108Regulation of autophagy_Homo sapiens_hsa041400.44432857
109MAPK signaling pathway_Homo sapiens_hsa040100.42670167
110Homologous recombination_Homo sapiens_hsa034400.41948144
111Pyruvate metabolism_Homo sapiens_hsa006200.41224795
112Non-homologous end-joining_Homo sapiens_hsa034500.41091448
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40881423
114Histidine metabolism_Homo sapiens_hsa003400.40846477
115Dilated cardiomyopathy_Homo sapiens_hsa054140.39988135
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39283725
117Thyroid hormone synthesis_Homo sapiens_hsa049180.38285851
118Mismatch repair_Homo sapiens_hsa034300.38197760
119Nucleotide excision repair_Homo sapiens_hsa034200.37479669
120Tuberculosis_Homo sapiens_hsa051520.35816159
121Glucagon signaling pathway_Homo sapiens_hsa049220.35811822
122Ovarian steroidogenesis_Homo sapiens_hsa049130.35652118
123Ras signaling pathway_Homo sapiens_hsa040140.35598487
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35160609
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.34790946
126Graft-versus-host disease_Homo sapiens_hsa053320.34343379
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.32556298
128Inositol phosphate metabolism_Homo sapiens_hsa005620.32546514
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31590166
130Circadian rhythm_Homo sapiens_hsa047100.29304876
131Alcoholism_Homo sapiens_hsa050340.28911605
132Dorso-ventral axis formation_Homo sapiens_hsa043200.28786302
133Protein export_Homo sapiens_hsa030600.26961967
134Prion diseases_Homo sapiens_hsa050200.26693001
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.25743741
136Choline metabolism in cancer_Homo sapiens_hsa052310.25037487
137Allograft rejection_Homo sapiens_hsa053300.20351732
138Salmonella infection_Homo sapiens_hsa051320.19824608
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.19461111
140Autoimmune thyroid disease_Homo sapiens_hsa053200.18088088
141VEGF signaling pathway_Homo sapiens_hsa043700.17978920
142Chemokine signaling pathway_Homo sapiens_hsa040620.17730235
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17536785
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17494209
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17055010
146Lysosome_Homo sapiens_hsa041420.16558935
147Mineral absorption_Homo sapiens_hsa049780.16437705
148Rap1 signaling pathway_Homo sapiens_hsa040150.15797527
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14443557
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13117801
151Endocytosis_Homo sapiens_hsa041440.13012277

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