ATP6V1E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.06661417
2cellular potassium ion homeostasis (GO:0030007)4.73911342
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.67121787
4neuronal action potential propagation (GO:0019227)4.58582658
5vocalization behavior (GO:0071625)4.44545641
6neuron cell-cell adhesion (GO:0007158)4.38285369
7glutamate secretion (GO:0014047)4.29828176
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24759616
9regulation of synaptic vesicle exocytosis (GO:2000300)4.24480503
10* ATP hydrolysis coupled proton transport (GO:0015991)4.21664555
11* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.21664555
12sodium ion export (GO:0071436)4.18726917
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.13222206
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.08670337
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99191173
16protein localization to synapse (GO:0035418)3.96743728
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93039465
18ATP synthesis coupled proton transport (GO:0015986)3.93039465
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85514898
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.84473981
21negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84371876
22* transferrin transport (GO:0033572)3.82624183
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.81198374
24regulation of glutamate receptor signaling pathway (GO:1900449)3.79947529
25regulation of synaptic vesicle transport (GO:1902803)3.75253502
26neurotransmitter secretion (GO:0007269)3.74122390
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.73638433
28regulation of oxidative phosphorylation (GO:0002082)3.72803061
29neuron-neuron synaptic transmission (GO:0007270)3.68972633
30* trivalent inorganic cation transport (GO:0072512)3.54223623
31* ferric iron transport (GO:0015682)3.54223623
32glutamate receptor signaling pathway (GO:0007215)3.54089200
33respiratory electron transport chain (GO:0022904)3.54047523
34regulation of glutamate secretion (GO:0014048)3.48257139
35electron transport chain (GO:0022900)3.47229317
36behavioral response to cocaine (GO:0048148)3.43821686
37synaptic vesicle maturation (GO:0016188)3.40689263
38synaptic transmission, glutamatergic (GO:0035249)3.40330631
39presynaptic membrane assembly (GO:0097105)3.39169188
40regulation of early endosome to late endosome transport (GO:2000641)3.36364035
41detection of calcium ion (GO:0005513)3.35069479
42* phagosome maturation (GO:0090382)3.29727183
43negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.29570092
44neurotransmitter transport (GO:0006836)3.28901656
45potassium ion homeostasis (GO:0055075)3.26613823
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25858192
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25239999
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.25209442
49presynaptic membrane organization (GO:0097090)3.24809678
50chaperone-mediated protein transport (GO:0072321)3.23540193
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23331945
52long-term synaptic potentiation (GO:0060291)3.22982350
53locomotory exploration behavior (GO:0035641)3.22804698
54neuron recognition (GO:0008038)3.21669066
55regulation of vesicle fusion (GO:0031338)3.19089046
56protein maturation by protein folding (GO:0022417)3.15011766
57regulation of neuronal synaptic plasticity (GO:0048168)3.14191651
58regulation of postsynaptic membrane potential (GO:0060078)3.11464308
59synaptic transmission, dopaminergic (GO:0001963)3.10637223
60vesicle docking involved in exocytosis (GO:0006904)3.10108356
61negative regulation of amino acid transport (GO:0051956)3.09156082
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08685292
63response to histamine (GO:0034776)3.08361999
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04865548
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04011339
66gamma-aminobutyric acid transport (GO:0015812)3.03409292
67Golgi transport vesicle coating (GO:0048200)3.03247095
68COPI coating of Golgi vesicle (GO:0048205)3.03247095
69exploration behavior (GO:0035640)3.02007056
70synaptic vesicle endocytosis (GO:0048488)3.01537003
71regulation of neurotransmitter secretion (GO:0046928)3.00964415
72regulation of neurotransmitter levels (GO:0001505)3.00051417
73negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.98296122
74positive regulation of membrane potential (GO:0045838)2.94788271
75proline transport (GO:0015824)2.94725619
76amino acid import (GO:0043090)2.94347483
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93815238
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93097956
79protein localization to endosome (GO:0036010)2.92940931
80regulation of dopamine metabolic process (GO:0042053)2.92629705
81regulation of catecholamine metabolic process (GO:0042069)2.92629705
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91874568
83L-amino acid import (GO:0043092)2.91417674
84glycosphingolipid catabolic process (GO:0046479)2.90473123
85positive regulation of neurotransmitter transport (GO:0051590)2.90100233
86negative regulation of response to reactive oxygen species (GO:1901032)2.89621328
87* hydrogen ion transmembrane transport (GO:1902600)2.88693138
88transmission of nerve impulse (GO:0019226)2.88655665
89regulation of synaptic plasticity (GO:0048167)2.88229293
90regulation of voltage-gated calcium channel activity (GO:1901385)2.86822045
91regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.86600086
92regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.86600086
93regulation of synaptic transmission, glutamatergic (GO:0051966)2.86102305
94negative regulation of neurotransmitter transport (GO:0051589)2.85225266
95positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.84485861
96establishment of synaptic vesicle localization (GO:0097480)2.82375014
97synaptic vesicle transport (GO:0048489)2.82375014
98regulation of protein kinase A signaling (GO:0010738)2.82206478
99regulation of neurotransmitter transport (GO:0051588)2.81772552
100long-term memory (GO:0007616)2.81287543
101regulation of synapse structural plasticity (GO:0051823)2.81144397
102vesicle docking (GO:0048278)2.80898022
103fear response (GO:0042596)2.79607165
104cellular response to thyroid hormone stimulus (GO:0097067)2.79210840
105neurotransmitter-gated ion channel clustering (GO:0072578)2.79000515
106neuromuscular process controlling posture (GO:0050884)2.78604298
107negative regulation of amine transport (GO:0051953)2.76868165
108calcium-mediated signaling using intracellular calcium source (GO:0035584)2.76751211
109cerebellar Purkinje cell layer development (GO:0021680)2.76323346
110positive regulation of neurotransmitter secretion (GO:0001956)2.76204931
111regulation of hydrogen peroxide-induced cell death (GO:1903205)2.76151494
112mating behavior (GO:0007617)2.73231337
113postsynaptic membrane organization (GO:0001941)2.72775209
114synaptic transmission (GO:0007268)2.72375914
115endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.71882349
116negative regulation of dendrite morphogenesis (GO:0050774)2.71334688
117membrane depolarization (GO:0051899)2.70718120
118protein neddylation (GO:0045116)2.70079061
119behavioral fear response (GO:0001662)2.67894916
120behavioral defense response (GO:0002209)2.67894916
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.67275720
122response to cocaine (GO:0042220)2.67182427
123positive regulation of protein dephosphorylation (GO:0035307)2.65451303
124potassium ion import (GO:0010107)2.65101806
125dopamine biosynthetic process (GO:0042416)2.64737080
126striatum development (GO:0021756)2.64539416
127startle response (GO:0001964)2.63273145
128adenosine receptor signaling pathway (GO:0001973)2.63094271
129positive regulation of synapse assembly (GO:0051965)2.62440142
130oligosaccharide catabolic process (GO:0009313)2.60588131
131glycolipid catabolic process (GO:0019377)2.58376791
132deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.55407274
133cerebellar granule cell differentiation (GO:0021707)2.54348841
134cell communication by electrical coupling (GO:0010644)2.54311260
135response to thyroid hormone (GO:0097066)2.53967523
136positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.52274289
137cellular copper ion homeostasis (GO:0006878)2.50381076
138regulation of protein dephosphorylation (GO:0035304)2.49604838
139NADH metabolic process (GO:0006734)2.44600101
140negative regulation of cation channel activity (GO:2001258)2.43162699
141negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.42705049
142positive regulation of cellular amide metabolic process (GO:0034250)2.40370374
143regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.40350845
144* iron ion transport (GO:0006826)2.39970146
145membrane docking (GO:0022406)2.39942398
146negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.39663333
147neuromuscular process controlling balance (GO:0050885)2.38629775
148regulation of ARF protein signal transduction (GO:0032012)2.38200001
149barbed-end actin filament capping (GO:0051016)2.36819314
150clathrin coat assembly (GO:0048268)2.35243748
151regulation of cell communication by electrical coupling (GO:0010649)2.35082839
152regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.34628567
153cytoskeletal anchoring at plasma membrane (GO:0007016)2.34049820
154neurotransmitter uptake (GO:0001504)2.33859057
155regulation of integrin-mediated signaling pathway (GO:2001044)2.33142387
156positive regulation of receptor recycling (GO:0001921)2.32975080
157retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.29981818
158substantia nigra development (GO:0021762)2.29888711
159positive regulation of synapse maturation (GO:0090129)2.28958753
160regulation of exocytosis (GO:0017157)2.27459155
161regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.26305525
162response to acidic pH (GO:0010447)2.24396473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41780596
2GBX2_23144817_ChIP-Seq_PC3_Human4.06988230
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.25154568
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09819604
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92187617
6TAF15_26573619_Chip-Seq_HEK293_Human2.80647595
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80179087
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62599222
9REST_21632747_ChIP-Seq_MESCs_Mouse2.59846638
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59322377
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51260249
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.50973568
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44863563
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42872902
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40056240
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38552623
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35153230
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33749938
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33749938
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32552267
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26028518
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.25964889
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20752688
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19888678
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.17814360
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17538733
27SRY_22984422_ChIP-ChIP_TESTIS_Rat2.16580248
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.14300523
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13375683
30VDR_22108803_ChIP-Seq_LS180_Human2.10070062
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06814946
32RARB_27405468_Chip-Seq_BRAIN_Mouse2.02877525
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99120678
34ZNF263_19887448_ChIP-Seq_K562_Human1.98879864
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96581694
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94056662
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.91768745
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.88303007
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87031481
40* TFEB_21752829_ChIP-Seq_HELA_Human1.80347278
41P300_19829295_ChIP-Seq_ESCs_Human1.77488134
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.76045536
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75918304
44SMAD4_21799915_ChIP-Seq_A2780_Human1.74413473
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74310623
46GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.73954236
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.73357435
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70934868
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70200154
50CLOCK_20551151_ChIP-Seq_293T_Human1.68275981
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68218294
52LXR_22292898_ChIP-Seq_THP-1_Human1.65355951
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65284554
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.65032796
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59740914
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59101141
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.58245435
58DROSHA_22980978_ChIP-Seq_HELA_Human1.56043329
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.55825168
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55660245
61TET1_21490601_ChIP-Seq_MESCs_Mouse1.55278603
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53897923
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53532094
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50647475
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47036176
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46290179
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45114669
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44651484
69AR_21572438_ChIP-Seq_LNCaP_Human1.43526113
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43482165
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.42041921
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41051126
73FUS_26573619_Chip-Seq_HEK293_Human1.40676207
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.39575800
75IGF1R_20145208_ChIP-Seq_DFB_Human1.39535254
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38709241
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38666021
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.38147382
79KDM2B_26808549_Chip-Seq_K562_Human1.37734952
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34981951
81ZNF274_21170338_ChIP-Seq_K562_Hela1.34784743
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34530811
83* PIAS1_25552417_ChIP-Seq_VCAP_Human1.33950101
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33570016
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33372308
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33318396
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31697514
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31422286
89* AR_25329375_ChIP-Seq_VCAP_Human1.31260378
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30929994
91ER_23166858_ChIP-Seq_MCF-7_Human1.30204550
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30139599
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.28001546
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26929591
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25403901
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.24483342
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23193869
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22806008
99* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22159465
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20550936
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18872253
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.17645830
103RACK7_27058665_Chip-Seq_MCF-7_Human1.17049827
104* JUN_21703547_ChIP-Seq_K562_Human1.16307189
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16279754
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15632791
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14782861
108TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14589905
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.14451234
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10923747
111RNF2_27304074_Chip-Seq_NSC_Mouse1.10560275
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.10531237
113SOX2_20726797_ChIP-Seq_SW620_Human1.10342984
114SPI1_23127762_ChIP-Seq_K562_Human1.10079953
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07936177
116RUNX2_22187159_ChIP-Seq_PCA_Human1.07039361
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06073984
118STAT3_23295773_ChIP-Seq_U87_Human1.05918260
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05830184
120EOMES_21245162_ChIP-Seq_HESCs_Human1.05739224
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05614286
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05578936
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05337064
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.05249272
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04915953
126MYC_19915707_ChIP-ChIP_AK7_Human1.03610810
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.03487422
128ELK3_25401928_ChIP-Seq_HUVEC_Human1.03012219
129SMAD_19615063_ChIP-ChIP_OVARY_Human1.02681842
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02190930
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01478133
132NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01478133
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01401278
134BCAT_22108803_ChIP-Seq_LS180_Human0.99966503
135E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98461659
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98379780
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98146599
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97997119
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97895335
140TCF4_23295773_ChIP-Seq_U87_Human0.97551692
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97415811
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97194831
143P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97103472
144GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96576766
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96475719
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96454300
147TBX20_22328084_ChIP-Seq_HEART_Mouse0.95857334
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.95857334
149GATA1_19941826_ChIP-Seq_K562_Human0.95605059
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95541385
151UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95506437
152ATF3_27146783_Chip-Seq_COLON_Human0.95412512
153CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93897631
154TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93877285
155PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93735079
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92982897
157TP53_18474530_ChIP-ChIP_U2OS_Human0.92824947
158* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92781581
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92734087
160OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92241831
161KDM2B_26808549_Chip-Seq_REH_Human0.91495933
162* GATA1_19941827_ChIP-Seq_MEL_Mouse0.91383800
163ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91281992
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90932138
165CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90791830
166CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90603415
167P53_22387025_ChIP-Seq_ESCs_Mouse0.89623532
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89577138
169RXR_22158963_ChIP-Seq_LIVER_Mouse0.88933494
170CMYC_18555785_Chip-Seq_ESCs_Mouse0.88222763
171MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88149086
172GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87434955
173IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87145315
174CBP_20019798_ChIP-Seq_JUKART_Human0.87145315
175SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87095927
176FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86811085
177CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86508801
178FLI1_21867929_ChIP-Seq_TH2_Mouse0.86271230
179E2F1_18555785_Chip-Seq_ESCs_Mouse0.86215706
180TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86074419
181RING1B_27294783_Chip-Seq_ESCs_Mouse0.85956744
182CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84764326
183* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84075468
184TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83298165
185ARNT_22903824_ChIP-Seq_MCF-7_Human0.82479381
186SOX2_18555785_Chip-Seq_ESCs_Mouse0.80546092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.22256843
2MP0004859_abnormal_synaptic_plasticity4.85955533
3MP0005058_abnormal_lysosome_morphology3.72464275
4MP0003635_abnormal_synaptic_transmissio3.57103190
5MP0004270_analgesia3.28734972
6MP0009745_abnormal_behavioral_response3.28012586
7MP0002064_seizures3.20340491
8MP0001968_abnormal_touch/_nociception3.19383356
9MP0009046_muscle_twitch3.11948408
10MP0002063_abnormal_learning/memory/cond2.92694178
11MP0002736_abnormal_nociception_after2.92570042
12MP0002735_abnormal_chemical_nociception2.74712013
13MP0002822_catalepsy2.72646499
14MP0001501_abnormal_sleep_pattern2.72237176
15MP0002572_abnormal_emotion/affect_behav2.71035663
16MP0002272_abnormal_nervous_system2.63926246
17MP0002734_abnormal_mechanical_nocicepti2.59364015
18MP0001440_abnormal_grooming_behavior2.54178745
19MP0009840_abnormal_foam_cell2.52422960
20MP0003172_abnormal_lysosome_physiology2.47372640
21MP0006276_abnormal_autonomic_nervous2.37684308
22MP0002837_dystrophic_cardiac_calcinosis2.30208581
23MP0001529_abnormal_vocalization2.24629762
24MP0000343_altered_response_to2.21052504
25MP0002733_abnormal_thermal_nociception2.19174690
26MP0001970_abnormal_pain_threshold2.17558187
27MP0010386_abnormal_urinary_bladder2.15448739
28MP0001486_abnormal_startle_reflex2.12887916
29MP0001905_abnormal_dopamine_level2.07544620
30MP0003329_amyloid_beta_deposits2.04423818
31MP0002067_abnormal_sensory_capabilities2.03198689
32MP0003191_abnormal_cellular_cholesterol1.90068487
33MP0005423_abnormal_somatic_nervous1.77885997
34MP0001984_abnormal_olfaction1.76840085
35MP0003303_peritoneal_inflammation1.76212479
36MP0006082_CNS_inflammation1.76041773
37MP0004924_abnormal_behavior1.74932784
38MP0005386_behavior/neurological_phenoty1.74932784
39MP0003806_abnormal_nucleotide_metabolis1.62900958
40MP0002184_abnormal_innervation1.61829724
41MP0002877_abnormal_melanocyte_morpholog1.58365865
42MP0004142_abnormal_muscle_tone1.49672731
43MP0005464_abnormal_platelet_physiology1.49165119
44MP0002909_abnormal_adrenal_gland1.48334857
45MP0004858_abnormal_nervous_system1.47540258
46MP0002557_abnormal_social/conspecific_i1.46411842
47MP0005166_decreased_susceptibility_to1.45009869
48MP0005646_abnormal_pituitary_gland1.44522753
49MP0000013_abnormal_adipose_tissue1.42077838
50MP0003123_paternal_imprinting1.41216537
51MP0003186_abnormal_redox_activity1.41090400
52MP0005451_abnormal_body_composition1.40128361
53MP0008569_lethality_at_weaning1.39523512
54MP0010234_abnormal_vibrissa_follicle1.38330139
55MP0000778_abnormal_nervous_system1.38206000
56MP0009780_abnormal_chondrocyte_physiolo1.36996903
57MP0003879_abnormal_hair_cell1.36932396
58MP0002876_abnormal_thyroid_physiology1.36322665
59MP0002066_abnormal_motor_capabilities/c1.33381682
60MP0004811_abnormal_neuron_physiology1.32604408
61MP0002638_abnormal_pupillary_reflex1.31656615
62MP0000955_abnormal_spinal_cord1.30505805
63MP0005165_increased_susceptibility_to1.27572022
64MP0002148_abnormal_hypersensitivity_rea1.23982566
65MP0003633_abnormal_nervous_system1.21794928
66MP0005535_abnormal_body_temperature1.21677741
67MP0005167_abnormal_blood-brain_barrier1.19493545
68MP0002882_abnormal_neuron_morphology1.19486492
69MP0004043_abnormal_pH_regulation1.19346066
70MP0001502_abnormal_circadian_rhythm1.18187894
71MP0000604_amyloidosis1.17906690
72MP0001188_hyperpigmentation1.16495832
73MP0004147_increased_porphyrin_level1.15834797
74MP0003566_abnormal_cell_adhesion1.14119842
75MP0001853_heart_inflammation1.12815680
76MP0000747_muscle_weakness1.11858002
77MP0005171_absent_coat_pigmentation1.11515602
78MP0002295_abnormal_pulmonary_circulatio1.10562127
79MP0002229_neurodegeneration1.10399737
80MP0004742_abnormal_vestibular_system1.09497064
81MP0005645_abnormal_hypothalamus_physiol1.07986162
82MP0003631_nervous_system_phenotype1.07339237
83MP0001986_abnormal_taste_sensitivity1.05450967
84MP0008872_abnormal_physiological_respon1.04385656
85MP0003122_maternal_imprinting1.03075701
86MP0000920_abnormal_myelination1.01399473
87MP0005379_endocrine/exocrine_gland_phen0.99395179
88MP0005551_abnormal_eye_electrophysiolog0.94905137
89MP0003634_abnormal_glial_cell0.93131516
90MP0000749_muscle_degeneration0.89020494
91MP0008438_abnormal_cutaneous_collagen0.88744873
92MP0002090_abnormal_vision0.88612221
93MP0003195_calcinosis0.88212817
94MP0005584_abnormal_enzyme/coenzyme_acti0.87917269
95MP0008874_decreased_physiological_sensi0.87485956
96MP0002069_abnormal_eating/drinking_beha0.86571740
97MP0001963_abnormal_hearing_physiology0.86502013
98MP0004484_altered_response_of0.84636104
99MP0003300_gastrointestinal_ulcer0.82865899
100MP0008260_abnormal_autophagy0.82337921
101MP0001542_abnormal_bone_strength0.81712327
102MP0002163_abnormal_gland_morphology0.80990873
103MP0003656_abnormal_erythrocyte_physiolo0.80414511
104MP0003690_abnormal_glial_cell0.79826596
105MP0004885_abnormal_endolymph0.78938503
106MP0001727_abnormal_embryo_implantation0.78668496
107MP0000751_myopathy0.78653298
108MP0004145_abnormal_muscle_electrophysio0.78029646
109MP0003632_abnormal_nervous_system0.76869285
110MP0003787_abnormal_imprinting0.75045704
111MP0002152_abnormal_brain_morphology0.73897448
112MP0003950_abnormal_plasma_membrane0.73566301
113MP0002972_abnormal_cardiac_muscle0.72780270
114MP0006035_abnormal_mitochondrial_morpho0.72719226
115MP0002139_abnormal_hepatobiliary_system0.72461903
116MP0005623_abnormal_meninges_morphology0.71780706
117MP0004019_abnormal_vitamin_homeostasis0.71248940
118MP0004085_abnormal_heartbeat0.70874143
119MP0001664_abnormal_digestion0.70696664
120MP0001756_abnormal_urination0.70421134
121MP0002998_abnormal_bone_remodeling0.70414007
122MP0002752_abnormal_somatic_nervous0.70231329
123MP0000372_irregular_coat_pigmentation0.70085262
124MP0001533_abnormal_skeleton_physiology0.67892362
125MP0003453_abnormal_keratinocyte_physiol0.67178199
126MP0004233_abnormal_muscle_weight0.66611067
127MP0009785_altered_susceptibility_to0.66505284
128MP0001765_abnormal_ion_homeostasis0.66148209
129MP0003646_muscle_fatigue0.66043347
130MP0002419_abnormal_innate_immunity0.65955552
131MP0001348_abnormal_lacrimal_gland0.65812999
132MP0000538_abnormal_urinary_bladder0.65365151
133MP0005409_darkened_coat_color0.64610861
134MP0002693_abnormal_pancreas_physiology0.62892852
135MP0002332_abnormal_exercise_endurance0.62263733
136MP0003183_abnormal_peptide_metabolism0.61507478
137MP0005000_abnormal_immune_tolerance0.61337798
138MP0004510_myositis0.60930862
139MP0006036_abnormal_mitochondrial_physio0.60482500
140MP0004215_abnormal_myocardial_fiber0.59888035
141MP0004947_skin_inflammation0.59751522
142MP0004036_abnormal_muscle_relaxation0.58020838
143MP0003075_altered_response_to0.56345483
144MP0001485_abnormal_pinna_reflex0.55352515
145MP0005499_abnormal_olfactory_system0.55294243
146MP0005394_taste/olfaction_phenotype0.55294243

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.21219825
2Myokymia (HP:0002411)5.16365244
3Atonic seizures (HP:0010819)5.03578328
4Abnormality of liposaccharide metabolism (HP:0010968)4.86713095
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.86713095
6Abnormality of glycolipid metabolism (HP:0010969)4.86713095
7Focal seizures (HP:0007359)4.81093388
8Visual hallucinations (HP:0002367)4.72159692
9Acute necrotizing encephalopathy (HP:0006965)4.52067048
10Epileptic encephalopathy (HP:0200134)4.38422971
11Absence seizures (HP:0002121)4.25783462
12Febrile seizures (HP:0002373)4.17587633
13Abnormal mitochondria in muscle tissue (HP:0008316)4.17082460
14Dialeptic seizures (HP:0011146)4.03019189
15Progressive macrocephaly (HP:0004481)3.94697616
16Mitochondrial inheritance (HP:0001427)3.74770343
17Hyperventilation (HP:0002883)3.69849143
18Generalized tonic-clonic seizures (HP:0002069)3.65072960
19Acute encephalopathy (HP:0006846)3.57426094
20Pheochromocytoma (HP:0002666)3.27770293
21Supranuclear gaze palsy (HP:0000605)3.16467839
22Amblyopia (HP:0000646)3.14462930
23Dysostosis multiplex (HP:0000943)3.13934523
24Progressive cerebellar ataxia (HP:0002073)3.11502193
25Cerebral inclusion bodies (HP:0100314)3.11029199
26Increased CSF lactate (HP:0002490)3.10544099
27Neuroendocrine neoplasm (HP:0100634)3.10106176
28Apathy (HP:0000741)3.02337008
29Diminished motivation (HP:0000745)2.92174275
30Neuronal loss in central nervous system (HP:0002529)2.91805100
31Vacuolated lymphocytes (HP:0001922)2.91642753
32Neurofibrillary tangles (HP:0002185)2.88226124
33Hepatocellular necrosis (HP:0001404)2.87340243
34Loss of speech (HP:0002371)2.81369536
35Anxiety (HP:0000739)2.81026616
36Tetraplegia (HP:0002445)2.79588939
37Hypothermia (HP:0002045)2.76880891
38Axonal loss (HP:0003447)2.68439146
39Limb dystonia (HP:0002451)2.68022532
40Broad-based gait (HP:0002136)2.65862584
41Abnormal eating behavior (HP:0100738)2.64150094
42Focal dystonia (HP:0004373)2.63751605
43Craniofacial dystonia (HP:0012179)2.60604982
44Progressive inability to walk (HP:0002505)2.60407768
45Nuclear cataract (HP:0100018)2.58668072
46Polyphagia (HP:0002591)2.56915602
47Optic disc pallor (HP:0000543)2.55768761
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.54264946
49Increased hepatocellular lipid droplets (HP:0006565)2.52583401
50Delusions (HP:0000746)2.51665238
51Progressive neurologic deterioration (HP:0002344)2.50356409
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45984033
53Abnormality of polysaccharide metabolism (HP:0011012)2.45984033
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45984033
55Mucopolysacchariduria (HP:0008155)2.39776384
56Urinary glycosaminoglycan excretion (HP:0003541)2.39776384
57Increased serum pyruvate (HP:0003542)2.38998866
58Abnormality of glycolysis (HP:0004366)2.38998866
59Cerebral hypomyelination (HP:0006808)2.36886101
60Action tremor (HP:0002345)2.36821361
61Gait imbalance (HP:0002141)2.36648303
62Rigidity (HP:0002063)2.36323348
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.35740934
64Torticollis (HP:0000473)2.35135411
65Poor eye contact (HP:0000817)2.34726316
66Truncal ataxia (HP:0002078)2.34591188
67Epileptiform EEG discharges (HP:0011182)2.34007206
68Petechiae (HP:0000967)2.33132351
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.32729625
70Leukodystrophy (HP:0002415)2.32570130
71Dysmetria (HP:0001310)2.31290568
72Abnormality of binocular vision (HP:0011514)2.31168920
73Diplopia (HP:0000651)2.31168920
74Renal Fanconi syndrome (HP:0001994)2.30707562
75Cerebral edema (HP:0002181)2.30070758
76Vertebral compression fractures (HP:0002953)2.29131837
77Intention tremor (HP:0002080)2.28535525
78Medial flaring of the eyebrow (HP:0010747)2.26598149
79Hypokinesia (HP:0002375)2.25394413
80Gaze-evoked nystagmus (HP:0000640)2.24633851
81Inability to walk (HP:0002540)2.21973391
82Bundle branch block (HP:0011710)2.20580754
83Spastic gait (HP:0002064)2.20385788
84Hepatic necrosis (HP:0002605)2.18755244
85EEG with generalized epileptiform discharges (HP:0011198)2.18533333
86Dementia (HP:0000726)2.15692535
87Congenital primary aphakia (HP:0007707)2.15483085
88Abnormality of macrophages (HP:0004311)2.14109191
89X-linked dominant inheritance (HP:0001423)2.12536181
90Dysdiadochokinesis (HP:0002075)2.12181819
91Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11967974
92Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11967974
93Impaired social interactions (HP:0000735)2.11747238
94Abnormal social behavior (HP:0012433)2.11747238
95Depression (HP:0000716)2.11205387
96Respiratory failure (HP:0002878)2.10961868
97Lipid accumulation in hepatocytes (HP:0006561)2.09590004
98Akinesia (HP:0002304)2.09579508
99Disinhibition (HP:0000734)2.07914089
100Psychosis (HP:0000709)2.07635695
101Insidious onset (HP:0003587)2.07277081
102Termporal pattern (HP:0011008)2.07277081
103Purpura (HP:0000979)2.06581865
104Tetraparesis (HP:0002273)2.05780480
105Nephrogenic diabetes insipidus (HP:0009806)2.05479071
106Increased cerebral lipofuscin (HP:0011813)2.05238074
107Generalized myoclonic seizures (HP:0002123)2.04426780
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04084749
109Degeneration of the lateral corticospinal tracts (HP:0002314)2.04084749
110Hemiparesis (HP:0001269)2.03571841
111Upper limb amyotrophy (HP:0009129)2.03090260
112Distal upper limb amyotrophy (HP:0007149)2.03090260
113Abnormal hair whorl (HP:0010721)2.02620765
114Hypsarrhythmia (HP:0002521)2.02251121
115Abnormal autonomic nervous system physiology (HP:0012332)2.02180912
116Increased intramyocellular lipid droplets (HP:0012240)2.00585528
117Hand muscle atrophy (HP:0009130)2.00195680
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99904503
119Distal lower limb muscle weakness (HP:0009053)1.97462676
120Retinal dysplasia (HP:0007973)1.97393997
121Hyperparathyroidism (HP:0000843)1.97004387
122Cerebral hemorrhage (HP:0001342)1.96797008
123Lactic acidosis (HP:0003128)1.95925552
124Exercise intolerance (HP:0003546)1.95557491
125Excessive salivation (HP:0003781)1.95531795
126Drooling (HP:0002307)1.95531795
127Ankle clonus (HP:0011448)1.95276603
128Abnormality of the corticospinal tract (HP:0002492)1.95169743
129Poor suck (HP:0002033)1.94654453
130Ventricular fibrillation (HP:0001663)1.92316179
131Peripheral hypomyelination (HP:0007182)1.91477264
132Failure to thrive in infancy (HP:0001531)1.90312811
133Dysautonomia (HP:0002459)1.89994887
134Abnormal gallbladder physiology (HP:0012438)1.88893254
135Cholecystitis (HP:0001082)1.88893254
136Impaired vibration sensation in the lower limbs (HP:0002166)1.86547951
137Hyperthyroidism (HP:0000836)1.86384055
138Resting tremor (HP:0002322)1.85957245
139Bradykinesia (HP:0002067)1.85220043
140Mutism (HP:0002300)1.85064712
141Blue irides (HP:0000635)1.84836857
142Esotropia (HP:0000565)1.84835238
143Systemic lupus erythematosus (HP:0002725)1.84191097
144Type II lissencephaly (HP:0007260)1.83919129
145Oligomenorrhea (HP:0000876)1.83903626
146Genital tract atresia (HP:0001827)1.83887112
147Vaginal atresia (HP:0000148)1.83606140
148Rapidly progressive (HP:0003678)1.81836179
149Hypoventilation (HP:0002791)1.80446863
150Emotional lability (HP:0000712)1.80138253
151Upper limb muscle weakness (HP:0003484)1.80119173
152Postural tremor (HP:0002174)1.77773260
153Asymmetric septal hypertrophy (HP:0001670)1.77047400
154Diminished movement (HP:0002374)1.72003417
155Lower limb muscle weakness (HP:0007340)1.71278895
156Choreoathetosis (HP:0001266)1.70344217
157Spastic tetraparesis (HP:0001285)1.66254712
158Tongue fasciculations (HP:0001308)1.65229277
159Abnormal atrioventricular conduction (HP:0005150)1.63976920
160Postural instability (HP:0002172)1.61841565
161Hyporeflexia of lower limbs (HP:0002600)1.61535497
162Esophageal neoplasm (HP:0100751)1.60653683
163Neoplasm of head and neck (HP:0012288)1.60653683
164CNS hypomyelination (HP:0003429)1.59608967
165Global brain atrophy (HP:0002283)1.59578293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.81092556
2NTRK33.67426018
3EPHA43.52837844
4RIPK43.35953390
5CASK3.01989827
6MAP3K42.97790743
7MAP3K92.82073994
8MAP2K72.77999866
9ARAF2.68311038
10TESK12.48522495
11GRK52.40004159
12NME22.35604137
13PLK22.29245441
14MINK12.23501243
15DAPK22.15821708
16NTRK11.97724531
17PNCK1.95463865
18IRAK31.93601388
19MAP2K41.92561316
20LATS21.85581907
21MAP3K111.79253899
22OXSR11.79092319
23DAPK11.72529224
24NME11.70322026
25KSR21.69379266
26CDK191.65286341
27BMPR21.63489809
28MARK11.62467259
29TAOK21.56115309
30GRK71.54341227
31PAK61.26311607
32NTRK21.23257169
33CDK51.23062550
34FGR1.22608688
35CAMKK21.20869044
36MAP3K131.20834055
37CAMK2A1.19432314
38PTK2B1.18192695
39PRKCG1.14612416
40MAP3K21.13820239
41MAP3K31.12805564
42PAK41.11252869
43STK391.09495197
44BCR1.06847930
45CAMK2B1.06785732
46FES1.03508863
47EIF2AK11.02526491
48RIPK11.02108548
49SCYL21.01387407
50KSR10.99744179
51WNK40.96811041
52PRKD30.96642418
53PRKCE0.95846533
54TNIK0.94292573
55BRAF0.92263342
56PIM20.89623273
57ALK0.89554055
58MYLK0.83625649
59MAPK130.82437806
60CAMK2D0.80943505
61ILK0.80870476
62MAPK120.80200579
63WNK30.78566954
64PRPF4B0.75982019
65CDK140.75663534
66SGK2230.75308018
67SGK4940.75308018
68UHMK10.75301105
69PDK10.74980715
70STK160.74923142
71ADRBK10.74853035
72DDR20.74628497
73DAPK30.73325755
74AKT30.72612964
75ADRBK20.72612863
76CAMKK10.72091071
77PRKG20.71207055
78SIK30.70490543
79CDK180.69785701
80CAMK2G0.69449884
81MST40.68117551
82MUSK0.67125923
83CCNB10.67037567
84MAP2K10.66994811
85RAF10.66651627
86CSNK1G20.65806704
87PAK10.64484858
88CDK150.64277420
89GRK60.64250788
90MAPKAPK50.64074070
91LIMK10.62813507
92TBK10.62636103
93DYRK1A0.62377336
94MAP2K60.62005236
95MAP3K50.61292914
96MAPKAPK30.59760076
97PDK30.59261935
98PDK40.59261935
99MAP3K10.58890973
100PTK20.57168701
101PAK30.57001701
102FER0.56987850
103PRKCH0.55897849
104CDK11A0.55296683
105SIK20.55196482
106BMX0.54831786
107PDK20.54692176
108TESK20.54672176
109PDPK10.51301882
110PBK0.51202550
111PHKG10.50556268
112PHKG20.50556268
113BMPR1B0.50216809
114DMPK0.48832843
115PINK10.47655811
116SGK10.47356907
117ROCK20.45669995
118PRKACA0.44127509
119LMTK20.43697609
120TAOK10.43249143
121MAP2K30.42904816
122EPHB10.41470151
123JAK10.40977094
124CAMK10.40850938
125MOS0.40266205
126JAK20.39567611
127RET0.38749067
128ABL20.38416289
129INSRR0.37209995
130IRAK20.37092773
131CSNK1G30.36896768
132STK380.36281667
133PRKCZ0.35198283
134FYN0.34940064
135ERBB40.34509830
136PRKCA0.33743167
137ROCK10.32899429
138AKT20.31523265
139PRKCD0.30735757

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001903.71942593
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.70228781
3* Collecting duct acid secretion_Homo sapiens_hsa049663.50337177
4Nicotine addiction_Homo sapiens_hsa050333.48326668
5Parkinsons disease_Homo sapiens_hsa050122.79532321
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53594897
7Alzheimers disease_Homo sapiens_hsa050102.53160188
8GABAergic synapse_Homo sapiens_hsa047272.39924485
9Other glycan degradation_Homo sapiens_hsa005112.29872318
10* Vibrio cholerae infection_Homo sapiens_hsa051102.26042416
11Long-term potentiation_Homo sapiens_hsa047202.16841617
12Amphetamine addiction_Homo sapiens_hsa050312.12562311
13Morphine addiction_Homo sapiens_hsa050322.09704125
14Circadian entrainment_Homo sapiens_hsa047132.09598655
15Olfactory transduction_Homo sapiens_hsa047402.08343325
16Glutamatergic synapse_Homo sapiens_hsa047241.98224902
17Dopaminergic synapse_Homo sapiens_hsa047281.90328982
18Taste transduction_Homo sapiens_hsa047421.89427619
19Huntingtons disease_Homo sapiens_hsa050161.86409302
20Serotonergic synapse_Homo sapiens_hsa047261.81772920
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.80839794
22Cardiac muscle contraction_Homo sapiens_hsa042601.74193156
23Vitamin B6 metabolism_Homo sapiens_hsa007501.70058931
24Salivary secretion_Homo sapiens_hsa049701.69397804
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68292897
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60882115
27Insulin secretion_Homo sapiens_hsa049111.59286535
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56747860
29Renin secretion_Homo sapiens_hsa049241.52393858
30Long-term depression_Homo sapiens_hsa047301.50755891
31* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48010449
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45684043
33Cocaine addiction_Homo sapiens_hsa050301.45195437
34* Rheumatoid arthritis_Homo sapiens_hsa053231.41735741
35Cholinergic synapse_Homo sapiens_hsa047251.40708382
36Gastric acid secretion_Homo sapiens_hsa049711.35034748
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29580332
38Calcium signaling pathway_Homo sapiens_hsa040201.26317042
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24746433
40Phototransduction_Homo sapiens_hsa047441.18890432
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14083943
42Oxytocin signaling pathway_Homo sapiens_hsa049211.12901231
43Folate biosynthesis_Homo sapiens_hsa007901.11429035
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08970127
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04754791
46Type I diabetes mellitus_Homo sapiens_hsa049401.04369837
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03171407
48* Phagosome_Homo sapiens_hsa041451.03071243
49Endocytosis_Homo sapiens_hsa041440.99389611
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95971190
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95952835
52GnRH signaling pathway_Homo sapiens_hsa049120.94928563
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91837319
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86824738
55Protein export_Homo sapiens_hsa030600.85082281
56Gap junction_Homo sapiens_hsa045400.84956584
57Pentose phosphate pathway_Homo sapiens_hsa000300.83854443
58Shigellosis_Homo sapiens_hsa051310.79287724
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79135815
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78179079
61Carbon metabolism_Homo sapiens_hsa012000.77751283
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75886928
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75554737
64cAMP signaling pathway_Homo sapiens_hsa040240.74209108
65Proteasome_Homo sapiens_hsa030500.73874406
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73766427
67Galactose metabolism_Homo sapiens_hsa000520.72307039
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.71568024
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69751147
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68707449
71Regulation of autophagy_Homo sapiens_hsa041400.67426640
72Pancreatic secretion_Homo sapiens_hsa049720.65119259
73Pertussis_Homo sapiens_hsa051330.63938396
74Estrogen signaling pathway_Homo sapiens_hsa049150.63750573
75Type II diabetes mellitus_Homo sapiens_hsa049300.63309501
76African trypanosomiasis_Homo sapiens_hsa051430.62166308
77Arginine and proline metabolism_Homo sapiens_hsa003300.61250959
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60868317
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60040261
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59780365
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59056039
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58026100
83Axon guidance_Homo sapiens_hsa043600.57861158
84Pyruvate metabolism_Homo sapiens_hsa006200.57838069
85VEGF signaling pathway_Homo sapiens_hsa043700.57764679
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56790958
87Fructose and mannose metabolism_Homo sapiens_hsa000510.55534300
88Melanogenesis_Homo sapiens_hsa049160.55528320
89Legionellosis_Homo sapiens_hsa051340.54757891
90Butanoate metabolism_Homo sapiens_hsa006500.54576291
91Glutathione metabolism_Homo sapiens_hsa004800.53089833
92Sulfur metabolism_Homo sapiens_hsa009200.52679088
93Osteoclast differentiation_Homo sapiens_hsa043800.52543296
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48305707
95Lysosome_Homo sapiens_hsa041420.48292822
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48196397
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45659483
98Thyroid hormone synthesis_Homo sapiens_hsa049180.44210894
99HIF-1 signaling pathway_Homo sapiens_hsa040660.43699002
100ErbB signaling pathway_Homo sapiens_hsa040120.43673651
101Circadian rhythm_Homo sapiens_hsa047100.43616002
102Amoebiasis_Homo sapiens_hsa051460.43510521
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.43305493
104Glioma_Homo sapiens_hsa052140.42288468
105Fatty acid elongation_Homo sapiens_hsa000620.42011774
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41674568
107Phenylalanine metabolism_Homo sapiens_hsa003600.41474509
108Prion diseases_Homo sapiens_hsa050200.41230441
109Insulin signaling pathway_Homo sapiens_hsa049100.33841133
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.32713957
111Mineral absorption_Homo sapiens_hsa049780.32619906
112Tyrosine metabolism_Homo sapiens_hsa003500.30018451
113Glucagon signaling pathway_Homo sapiens_hsa049220.29496837
114MAPK signaling pathway_Homo sapiens_hsa040100.29298439
115Alcoholism_Homo sapiens_hsa050340.29089890
116Oocyte meiosis_Homo sapiens_hsa041140.28254315
117Ether lipid metabolism_Homo sapiens_hsa005650.27520756
118Tuberculosis_Homo sapiens_hsa051520.27360276
119Sphingolipid metabolism_Homo sapiens_hsa006000.27280522
120Ras signaling pathway_Homo sapiens_hsa040140.27101688
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26143615
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25459775
123Dorso-ventral axis formation_Homo sapiens_hsa043200.25258111
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.24338483
125Inositol phosphate metabolism_Homo sapiens_hsa005620.22907671
126Choline metabolism in cancer_Homo sapiens_hsa052310.20380158
127Dilated cardiomyopathy_Homo sapiens_hsa054140.20050838
128Salmonella infection_Homo sapiens_hsa051320.19348513
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19196886
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18840553
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18073642

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