ATP6V1F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.55214178
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.17550708
3ATP synthesis coupled proton transport (GO:0015986)7.17550708
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.96749665
5respiratory electron transport chain (GO:0022904)6.10018923
6electron transport chain (GO:0022900)5.98468985
7protein neddylation (GO:0045116)5.44855590
8chaperone-mediated protein transport (GO:0072321)5.42916183
9protein complex biogenesis (GO:0070271)4.74323139
10ribosomal small subunit biogenesis (GO:0042274)4.38587915
11GTP biosynthetic process (GO:0006183)4.37127348
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.23597720
13NADH dehydrogenase complex assembly (GO:0010257)4.23597720
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23597720
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.19655712
16mitochondrial respiratory chain complex assembly (GO:0033108)4.16101146
17* hydrogen ion transmembrane transport (GO:1902600)4.11154544
18viral transcription (GO:0019083)4.04959054
19cotranslational protein targeting to membrane (GO:0006613)3.96683429
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87928435
21protein targeting to ER (GO:0045047)3.87461850
22purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.79788187
23translational termination (GO:0006415)3.78310616
24protein localization to endoplasmic reticulum (GO:0070972)3.75176356
25cytochrome complex assembly (GO:0017004)3.72438653
26* proton transport (GO:0015992)3.71163593
27purine nucleoside triphosphate biosynthetic process (GO:0009145)3.70470995
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68729490
29ribosomal small subunit assembly (GO:0000028)3.67722085
30regulation of oxidative phosphorylation (GO:0002082)3.67056195
31* ATP hydrolysis coupled proton transport (GO:0015991)3.66266840
32* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.66266840
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63911444
34ATP biosynthetic process (GO:0006754)3.63405570
35regulation of mitochondrial translation (GO:0070129)3.63367587
36* hydrogen transport (GO:0006818)3.62846309
37platelet dense granule organization (GO:0060155)3.57345140
38UTP biosynthetic process (GO:0006228)3.55433493
39respiratory chain complex IV assembly (GO:0008535)3.50627406
40dopamine transport (GO:0015872)3.47715073
41proteasome assembly (GO:0043248)3.39494982
42guanosine-containing compound biosynthetic process (GO:1901070)3.33767450
43ribonucleoside triphosphate biosynthetic process (GO:0009201)3.30777300
44* phagosome maturation (GO:0090382)3.28953870
45inner mitochondrial membrane organization (GO:0007007)3.28886215
46signal peptide processing (GO:0006465)3.28266074
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20064619
48viral life cycle (GO:0019058)3.18677535
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18034555
50purine nucleotide salvage (GO:0032261)3.14442684
51cellular protein complex disassembly (GO:0043624)3.14039914
52protein targeting to mitochondrion (GO:0006626)3.11069021
53* transferrin transport (GO:0033572)3.09444449
54antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.08593087
55amino sugar catabolic process (GO:0046348)3.07740524
56translational elongation (GO:0006414)3.07446655
57CTP metabolic process (GO:0046036)3.05798222
58CTP biosynthetic process (GO:0006241)3.05798222
59establishment of protein localization to mitochondrion (GO:0072655)3.03982733
60nucleoside diphosphate phosphorylation (GO:0006165)3.02377341
61dopamine biosynthetic process (GO:0042416)2.99663610
62UTP metabolic process (GO:0046051)2.99181150
63regulation of cellular amino acid metabolic process (GO:0006521)2.98623477
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96670353
65protein-cofactor linkage (GO:0018065)2.96014799
66signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94893941
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.94893941
68glycosphingolipid catabolic process (GO:0046479)2.93379266
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92491593
70signal transduction involved in cell cycle checkpoint (GO:0072395)2.91992993
71positive regulation of TOR signaling (GO:0032008)2.90733443
72positive regulation of prostaglandin secretion (GO:0032308)2.87879880
73nucleoside triphosphate biosynthetic process (GO:0009142)2.87857391
74sequestering of actin monomers (GO:0042989)2.86380177
75translation (GO:0006412)2.85977779
76oxidative phosphorylation (GO:0006119)2.85746126
77metallo-sulfur cluster assembly (GO:0031163)2.85185096
78iron-sulfur cluster assembly (GO:0016226)2.85185096
79purine-containing compound salvage (GO:0043101)2.84098186
80protein deneddylation (GO:0000338)2.82900836
81protein localization to mitochondrion (GO:0070585)2.82565068
82neutrophil activation involved in immune response (GO:0002283)2.81952575
83purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.80711684
84purine nucleoside monophosphate biosynthetic process (GO:0009127)2.80711684
85negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80655434
86* trivalent inorganic cation transport (GO:0072512)2.77699166
87* ferric iron transport (GO:0015682)2.77699166
88oligosaccharide catabolic process (GO:0009313)2.77479107
89termination of RNA polymerase III transcription (GO:0006386)2.76809855
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.76809855
91protein localization to cilium (GO:0061512)2.76758894
92positive regulation of ligase activity (GO:0051351)2.76347236
93regulation of dopamine metabolic process (GO:0042053)2.74598781
94regulation of catecholamine metabolic process (GO:0042069)2.74598781
95negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.73966424
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73789794
97intracellular protein transmembrane import (GO:0044743)2.73381975
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70256966
99viral protein processing (GO:0019082)2.69920155
100cellular response to zinc ion (GO:0071294)2.68216022
101protein targeting to membrane (GO:0006612)2.67303550
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65392913
103eosinophil chemotaxis (GO:0048245)2.62554379
104cullin deneddylation (GO:0010388)2.62304391
105glycolipid catabolic process (GO:0019377)2.62085467
106mannosylation (GO:0097502)2.60854303
107rRNA modification (GO:0000154)2.60660253
108aldehyde catabolic process (GO:0046185)2.60230367
109protein maturation by protein folding (GO:0022417)2.57782877
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56499146
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56499146
112positive regulation of mitochondrial fission (GO:0090141)2.55545472
113pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.54644670
114regulation of cellular amine metabolic process (GO:0033238)2.53938849
115long-chain fatty acid biosynthetic process (GO:0042759)2.52463431
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.52205750
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52205750
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.52205750
119aerobic respiration (GO:0009060)2.49322289
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49141011
121negative regulation of ligase activity (GO:0051352)2.49141011
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.48744524
123establishment of viral latency (GO:0019043)2.48739141
124mitochondrial transport (GO:0006839)2.47138359
125translational initiation (GO:0006413)2.46898501
126regulation of cellular respiration (GO:0043457)2.45780576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.56602160
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.91000549
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.60305403
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53513677
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.42055095
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.25749267
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.15169183
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03807341
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97673657
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92115397
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84300271
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.56789014
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.36006774
14TAF15_26573619_Chip-Seq_HEK293_Human2.35572038
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33117561
16EZH2_22144423_ChIP-Seq_EOC_Human2.30150157
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24438832
18VDR_22108803_ChIP-Seq_LS180_Human2.22205976
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15028480
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.12223200
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.08035127
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99136004
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.92140876
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88326325
25* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79474573
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78439707
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72711930
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71970263
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71841890
30* VDR_23849224_ChIP-Seq_CD4+_Human1.66386653
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65236974
32ELK1_19687146_ChIP-ChIP_HELA_Human1.62814934
33DCP1A_22483619_ChIP-Seq_HELA_Human1.60819982
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60671849
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.58592601
36GBX2_23144817_ChIP-Seq_PC3_Human1.57807067
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.57072972
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55377120
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51053991
40TFEB_21752829_ChIP-Seq_HELA_Human1.51009988
41IRF1_19129219_ChIP-ChIP_H3396_Human1.49638571
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45355765
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45070645
44* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42187047
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41203169
46* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39756882
47IGF1R_20145208_ChIP-Seq_DFB_Human1.38559614
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37843195
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.36657123
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35737259
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35484309
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35312859
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34900885
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.33031504
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32961110
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31394710
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31248136
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28494366
59* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28404083
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28211837
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28124178
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26174374
63CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21429685
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20914727
65* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20856791
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20166916
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19781927
68TTF2_22483619_ChIP-Seq_HELA_Human1.15572280
69BCL6_27268052_Chip-Seq_Bcells_Human1.14663630
70* MYC_18555785_ChIP-Seq_MESCs_Mouse1.12459060
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11563626
72FUS_26573619_Chip-Seq_HEK293_Human1.11127130
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11000293
74P300_19829295_ChIP-Seq_ESCs_Human1.10955057
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10925504
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10515468
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10168092
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09369878
79CTCF_26484167_Chip-Seq_Bcells_Mouse1.09161194
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09109202
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.08974435
82REST_21632747_ChIP-Seq_MESCs_Mouse1.08879161
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08297348
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07548848
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06634740
86SPI1_23547873_ChIP-Seq_NB4_Human1.06083311
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.05820030
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05333462
89* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05062519
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04702995
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04210620
92KDM5A_27292631_Chip-Seq_BREAST_Human1.03844863
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03843882
94* TET1_21451524_ChIP-Seq_MESCs_Mouse1.02021757
95XRN2_22483619_ChIP-Seq_HELA_Human1.00023247
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99472777
97FOXP3_21729870_ChIP-Seq_TREG_Human0.99186977
98CTCF_20526341_ChIP-Seq_ESCs_Human0.99000591
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98349670
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.98028477
101* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97491449
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94268597
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94222341
104MYC_18940864_ChIP-ChIP_HL60_Human0.94144984
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93373146
106SA1_27219007_Chip-Seq_Bcells_Human0.93145720
107STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92227281
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92096949
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91885488
110ER_23166858_ChIP-Seq_MCF-7_Human0.91827365
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91817532
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91443486
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91352157
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91202222
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90203717
116* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90153302
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.90023427
118BCOR_27268052_Chip-Seq_Bcells_Human0.89989935
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89682092
120SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89497375
121REST_18959480_ChIP-ChIP_MESCs_Mouse0.89370020
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88373075
123EED_16625203_ChIP-ChIP_MESCs_Mouse0.87272540
124RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87096542
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86987481
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86462078
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86220988
128* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86154389
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85612373
130RNF2_27304074_Chip-Seq_NSC_Mouse0.85360095
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84835224
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84053969
133STAT1_20625510_ChIP-Seq_HELA_Human0.83711397
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82654054
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82616621
136GABP_19822575_ChIP-Seq_HepG2_Human0.82040307
137HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81689601
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81601135
139LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81289081
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80373307
141FLI1_27457419_Chip-Seq_LIVER_Mouse0.79764874
142REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79377236
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76801178
144TAL1_26923725_Chip-Seq_HPCs_Mouse0.75670877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.27158677
2MP0003806_abnormal_nucleotide_metabolis3.74520762
3MP0009379_abnormal_foot_pigmentation3.45078411
4MP0001529_abnormal_vocalization3.17748425
5MP0009840_abnormal_foam_cell2.99521140
6MP0001905_abnormal_dopamine_level2.99005299
7MP0006276_abnormal_autonomic_nervous2.70874335
8MP0002736_abnormal_nociception_after2.67378415
9MP0000343_altered_response_to2.65771241
10MP0001968_abnormal_touch/_nociception2.54075909
11MP0010386_abnormal_urinary_bladder2.48167271
12MP0004270_analgesia2.44209514
13MP0003172_abnormal_lysosome_physiology2.41293791
14MP0002735_abnormal_chemical_nociception2.39078084
15MP0001986_abnormal_taste_sensitivity2.34285968
16MP0000372_irregular_coat_pigmentation2.15229728
17MP0002064_seizures2.11709505
18MP0002148_abnormal_hypersensitivity_rea2.08449696
19MP0002638_abnormal_pupillary_reflex2.03558103
20MP0002272_abnormal_nervous_system2.01024693
21MP0001970_abnormal_pain_threshold2.00058097
22MP0009745_abnormal_behavioral_response1.99992604
23MP0003075_altered_response_to1.96933196
24MP0002734_abnormal_mechanical_nocicepti1.92598743
25MP0004142_abnormal_muscle_tone1.92116415
26MP0005379_endocrine/exocrine_gland_phen1.91143882
27MP0009046_muscle_twitch1.87899911
28MP0001501_abnormal_sleep_pattern1.87896565
29MP0002139_abnormal_hepatobiliary_system1.84361692
30MP0002163_abnormal_gland_morphology1.83749573
31MP0009785_altered_susceptibility_to1.83321215
32MP0002733_abnormal_thermal_nociception1.81451645
33MP0003724_increased_susceptibility_to1.80665375
34MP0001440_abnormal_grooming_behavior1.79921134
35MP0000604_amyloidosis1.79421912
36MP0001835_abnormal_antigen_presentation1.74456573
37MP0002572_abnormal_emotion/affect_behav1.73686556
38MP0003635_abnormal_synaptic_transmissio1.73004652
39MP0001853_heart_inflammation1.69877466
40MP0003136_yellow_coat_color1.65777047
41MP0005645_abnormal_hypothalamus_physiol1.64647086
42MP0009764_decreased_sensitivity_to1.61211543
43MP0005171_absent_coat_pigmentation1.49546955
44MP0001764_abnormal_homeostasis1.48313978
45MP0003303_peritoneal_inflammation1.48289537
46MP0003011_delayed_dark_adaptation1.46110082
47MP0006036_abnormal_mitochondrial_physio1.46031250
48MP0005000_abnormal_immune_tolerance1.45396849
49MP0004859_abnormal_synaptic_plasticity1.42659592
50MP0002876_abnormal_thyroid_physiology1.41074629
51MP0001188_hyperpigmentation1.39728081
52MP0002067_abnormal_sensory_capabilities1.39469775
53MP0005671_abnormal_response_to1.36938594
54MP0002063_abnormal_learning/memory/cond1.36901274
55MP0004510_myositis1.36861872
56MP0003186_abnormal_redox_activity1.36128458
57MP0005423_abnormal_somatic_nervous1.35844958
58MP0006082_CNS_inflammation1.35155412
59MP0000920_abnormal_myelination1.34751506
60MP0001984_abnormal_olfaction1.34684443
61MP0002653_abnormal_ependyma_morphology1.26179635
62MP0000358_abnormal_cell_content/1.25095311
63MP0002837_dystrophic_cardiac_calcinosis1.24378721
64MP0005025_abnormal_response_to1.23429773
65MP0005167_abnormal_blood-brain_barrier1.22020559
66MP0008875_abnormal_xenobiotic_pharmacok1.21129640
67MP0008260_abnormal_autophagy1.19504897
68MP0005058_abnormal_lysosome_morphology1.19471037
69MP0002277_abnormal_respiratory_mucosa1.18666634
70MP0004742_abnormal_vestibular_system1.17157704
71MP0005409_darkened_coat_color1.16428597
72MP0003436_decreased_susceptibility_to1.16279838
73MP0005408_hypopigmentation1.15850837
74MP0003191_abnormal_cellular_cholesterol1.14735039
75MP0004924_abnormal_behavior1.13079290
76MP0005386_behavior/neurological_phenoty1.13079290
77MP0001486_abnormal_startle_reflex1.11974442
78MP0004043_abnormal_pH_regulation1.11363398
79MP0006072_abnormal_retinal_apoptosis1.09326846
80MP0005387_immune_system_phenotype1.07684733
81MP0001790_abnormal_immune_system1.07684733
82MP0001502_abnormal_circadian_rhythm1.07240731
83MP0008995_early_reproductive_senescence1.05945003
84MP0002419_abnormal_innate_immunity1.04813746
85MP0002184_abnormal_innervation1.04653959
86MP0005464_abnormal_platelet_physiology1.04494213
87MP0006292_abnormal_olfactory_placode1.03062851
88MP0005174_abnormal_tail_pigmentation1.03053334
89MP0008469_abnormal_protein_level1.01770431
90MP0003195_calcinosis1.01543188
91MP0005535_abnormal_body_temperature1.00979306
92MP0005636_abnormal_mineral_homeostasis1.00911137
93MP0005646_abnormal_pituitary_gland1.00118522
94MP0008872_abnormal_physiological_respon0.99813151
95MP0003122_maternal_imprinting0.99304415
96MP0006035_abnormal_mitochondrial_morpho0.98552340
97MP0002723_abnormal_immune_serum0.97810362
98MP0002822_catalepsy0.96588490
99MP0004019_abnormal_vitamin_homeostasis0.96239873
100MP0003183_abnormal_peptide_metabolism0.96145362
101MP0002557_abnormal_social/conspecific_i0.95718738
102MP0003633_abnormal_nervous_system0.94977164
103MP0001727_abnormal_embryo_implantation0.94827042
104MP0003879_abnormal_hair_cell0.94532791
105MP0000538_abnormal_urinary_bladder0.94223335
106MP0005166_decreased_susceptibility_to0.93436893
107MP0002095_abnormal_skin_pigmentation0.91315826
108MP0001845_abnormal_inflammatory_respons0.90251205
109MP0005397_hematopoietic_system_phenotyp0.90204420
110MP0001545_abnormal_hematopoietic_system0.90204420
111MP0005253_abnormal_eye_physiology0.89838031
112MP0002751_abnormal_autonomic_nervous0.89505166
113MP0008789_abnormal_olfactory_epithelium0.88962149
114MP0000015_abnormal_ear_pigmentation0.88430038
115MP0004147_increased_porphyrin_level0.88004694
116MP0002229_neurodegeneration0.87796608
117MP0001664_abnormal_digestion0.87069158
118MP0005075_abnormal_melanosome_morpholog0.87059007
119MP0005310_abnormal_salivary_gland0.86380192
120MP0005084_abnormal_gallbladder_morpholo0.86244581
121MP0005499_abnormal_olfactory_system0.85927847
122MP0005394_taste/olfaction_phenotype0.85927847
123MP0002132_abnormal_respiratory_system0.84502140
124MP0002693_abnormal_pancreas_physiology0.82559510
125MP0003786_premature_aging0.82219091
126MP0000750_abnormal_muscle_regeneration0.81753298
127MP0008058_abnormal_DNA_repair0.81659456
128MP0000681_abnormal_thyroid_gland0.81571678
129MP0002420_abnormal_adaptive_immunity0.81519650
130MP0001819_abnormal_immune_cell0.81263177
131MP0005584_abnormal_enzyme/coenzyme_acti0.80638265
132MP0003137_abnormal_impulse_conducting0.79884612
133MP0002452_abnormal_antigen_presenting0.79450887
134MP0000013_abnormal_adipose_tissue0.79339895
135MP0002066_abnormal_motor_capabilities/c0.79130433
136MP0002090_abnormal_vision0.78717658
137MP0001963_abnormal_hearing_physiology0.78599873
138MP0005551_abnormal_eye_electrophysiolog0.77798625
139MP0005410_abnormal_fertilization0.76119573
140MP0003329_amyloid_beta_deposits0.73595172

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.65037248
2Abnormal mitochondria in muscle tissue (HP:0008316)5.98514773
3Mitochondrial inheritance (HP:0001427)5.86546139
4Progressive macrocephaly (HP:0004481)5.55367108
5Abnormality of glycolipid metabolism (HP:0010969)5.31040059
6Abnormality of liposaccharide metabolism (HP:0010968)5.31040059
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.31040059
8Acute encephalopathy (HP:0006846)5.19245270
9Hepatocellular necrosis (HP:0001404)4.88864271
10Increased CSF lactate (HP:0002490)4.81903046
11Increased hepatocellular lipid droplets (HP:0006565)4.63911907
12Renal Fanconi syndrome (HP:0001994)4.36157536
13Hepatic necrosis (HP:0002605)4.02229857
14Lipid accumulation in hepatocytes (HP:0006561)3.99862079
15Hypothermia (HP:0002045)3.90075869
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.74261268
173-Methylglutaconic aciduria (HP:0003535)3.73201252
18Mutism (HP:0002300)3.61575967
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.54876279
20Optic disc pallor (HP:0000543)3.46961905
21Increased intramyocellular lipid droplets (HP:0012240)3.42135083
22Leukodystrophy (HP:0002415)3.40841527
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.36139292
24Exertional dyspnea (HP:0002875)3.35691828
25Abnormality of cells of the erythroid lineage (HP:0012130)3.34869742
26Respiratory failure (HP:0002878)3.33116427
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.30379684
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.30379684
29Exercise intolerance (HP:0003546)3.28468669
30Cerebral edema (HP:0002181)3.24563856
31Myokymia (HP:0002411)3.15640369
32Increased cerebral lipofuscin (HP:0011813)3.10002788
33Lactic acidosis (HP:0003128)3.05601571
34Abnormality of renal resorption (HP:0011038)3.00603039
35Generalized aminoaciduria (HP:0002909)2.99987701
36Abnormal number of erythroid precursors (HP:0012131)2.94165441
37Neuroendocrine neoplasm (HP:0100634)2.94138465
38Increased serum lactate (HP:0002151)2.83805007
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.81259793
40Increased serum pyruvate (HP:0003542)2.81114390
41Abnormality of glycolysis (HP:0004366)2.81114390
42Loss of speech (HP:0002371)2.79209000
43Parakeratosis (HP:0001036)2.78641764
44Pheochromocytoma (HP:0002666)2.77842705
45Increased muscle lipid content (HP:0009058)2.75810208
46Vacuolated lymphocytes (HP:0001922)2.74222445
47Abnormal gallbladder physiology (HP:0012438)2.61933381
48Cholecystitis (HP:0001082)2.61933381
49Abnormality of the anterior horn cell (HP:0006802)2.61797312
50Degeneration of anterior horn cells (HP:0002398)2.61797312
51Limb dystonia (HP:0002451)2.61293846
52Dysostosis multiplex (HP:0000943)2.60980190
53Respiratory difficulties (HP:0002880)2.56151185
54Reticulocytopenia (HP:0001896)2.44816326
55Disinhibition (HP:0000734)2.37585237
56Nausea (HP:0002018)2.37106583
57Abnormal hair whorl (HP:0010721)2.34000279
58Medial flaring of the eyebrow (HP:0010747)2.33331136
59Petechiae (HP:0000967)2.32617287
60Hyperphosphaturia (HP:0003109)2.28463228
61X-linked dominant inheritance (HP:0001423)2.26351976
62Prolonged neonatal jaundice (HP:0006579)2.25101916
63Cerebral hypomyelination (HP:0006808)2.24880947
64Aplastic anemia (HP:0001915)2.24145275
65Macrocytic anemia (HP:0001972)2.23944509
66Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23168432
67Congenital ichthyosiform erythroderma (HP:0007431)2.19927597
68Focal motor seizures (HP:0011153)2.18668921
69Progressive neurologic deterioration (HP:0002344)2.18485927
70Recurrent abscess formation (HP:0002722)2.17428725
71Abnormal pupillary function (HP:0007686)2.15166196
72Axonal loss (HP:0003447)2.13076788
73Emotional lability (HP:0000712)2.10766712
74Pallor (HP:0000980)2.10368811
75Poor head control (HP:0002421)2.09883270
76Systemic lupus erythematosus (HP:0002725)2.09688212
77Lethargy (HP:0001254)2.07476735
78Nuclear cataract (HP:0100018)2.06600758
79Increased IgM level (HP:0003496)2.05490956
80Renal tubular dysfunction (HP:0000124)2.00708902
81Gait imbalance (HP:0002141)2.00476627
82Abnormality of urine glucose concentration (HP:0011016)2.00120270
83Glycosuria (HP:0003076)2.00120270
84Congenital primary aphakia (HP:0007707)1.97590273
85Nephrogenic diabetes insipidus (HP:0009806)1.95628770
86Poor suck (HP:0002033)1.95541121
87Cerebral hemorrhage (HP:0001342)1.95420021
88Recurrent bacterial skin infections (HP:0005406)1.95237645
89Abnormal ciliary motility (HP:0012262)1.93186224
90Abnormality of macrophages (HP:0004311)1.92537376
91CNS demyelination (HP:0007305)1.91555351
92Visual hallucinations (HP:0002367)1.89863642
93Progressive microcephaly (HP:0000253)1.88519173
94Agnosia (HP:0010524)1.88460800
95Abnormal urine phosphate concentration (HP:0012599)1.88205992
96Neuronal loss in central nervous system (HP:0002529)1.87317878
97Multiple enchondromatosis (HP:0005701)1.87066125
98Hepatosplenomegaly (HP:0001433)1.86652055
99Methylmalonic aciduria (HP:0012120)1.86447446
100Atonic seizures (HP:0010819)1.86265539
101Abnormal autonomic nervous system physiology (HP:0012332)1.85990436
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84598502
103Dicarboxylic aciduria (HP:0003215)1.84598502
104Delusions (HP:0000746)1.84582761
105Retinal dysplasia (HP:0007973)1.84535458
106Vaginal atresia (HP:0000148)1.84301750
107Type I transferrin isoform profile (HP:0003642)1.84221927
108Diminished motivation (HP:0000745)1.83381559
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81170792
110Genital tract atresia (HP:0001827)1.79856254
111Abnormal respiratory epithelium morphology (HP:0012253)1.79775445
112Abnormal respiratory motile cilium morphology (HP:0005938)1.79775445
113Myoclonus (HP:0001336)1.78636325
114Apathy (HP:0000741)1.77031595
115Retinal atrophy (HP:0001105)1.74767869
116Increased neuronal autofluorescent lipopigment (HP:0002074)1.70074967
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69876229
118Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69336640
119Abnormality of polysaccharide metabolism (HP:0011012)1.69336640
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69336640
121CNS hypomyelination (HP:0003429)1.69152774
122Focal dystonia (HP:0004373)1.67743661
123Opisthotonus (HP:0002179)1.67613193
124Sensory axonal neuropathy (HP:0003390)1.67609765
125Vomiting (HP:0002013)1.67398779
126Polyphagia (HP:0002591)1.65621550
127Abnormality of magnesium homeostasis (HP:0004921)1.65542460
128Hypomagnesemia (HP:0002917)1.64261484
129Anxiety (HP:0000739)1.63289090
130Peripheral hypomyelination (HP:0007182)1.62482880
131Absent/shortened dynein arms (HP:0200106)1.61247362
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.61247362
133Absence seizures (HP:0002121)1.61138670
134Abnormal respiratory motile cilium physiology (HP:0012261)1.59560327
135Stomatitis (HP:0010280)1.54350657
136Progressive inability to walk (HP:0002505)1.53820512
137Blindness (HP:0000618)1.52165977
138Hypokinesia (HP:0002375)1.50890392
139Aplasia/hypoplasia of the uterus (HP:0008684)1.50066251
140Dialeptic seizures (HP:0011146)1.50061392
141Obstructive lung disease (HP:0006536)1.49666202
142Chronic obstructive pulmonary disease (HP:0006510)1.49666202
143Gliosis (HP:0002171)1.46990691
144Dysautonomia (HP:0002459)1.46519291
145Psychosis (HP:0000709)1.46480225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.55336951
2VRK24.42006114
3STK163.41700534
4CDK192.90319562
5ARAF2.83799877
6MST42.69366702
7NME22.67663459
8BCKDK2.62735338
9NME12.58225642
10RIPK42.47807989
11GRK52.37283030
12CASK2.36465805
13PBK2.26221852
14BMPR1B2.13956601
15PDK21.87415195
16PIM21.85867564
17GRK71.80087781
18ADRBK21.74034393
19OXSR11.70887811
20TAOK21.67351820
21MAPKAPK51.65548574
22MYLK1.65032915
23BMPR21.62725795
24MAP2K71.58845371
25MUSK1.57012314
26MAP4K21.56076433
27STK391.50956074
28VRK11.35647208
29BCR1.33188344
30WNK41.25742393
31TNIK1.25429270
32CSNK1A1L1.25084853
33SIK31.23172631
34TESK21.20797491
35NTRK31.18736453
36TRIM281.18287016
37EIF2AK11.17401795
38LIMK11.16821039
39CCNB11.14513346
40CAMK2B1.07595380
41PLK21.06084204
42TLK11.04567086
43CSNK1G11.04417387
44NEK11.03457094
45BLK1.02306776
46SYK0.98668935
47MATK0.98368994
48BRAF0.97871302
49BUB10.96139923
50DAPK10.94815581
51IRAK40.94493674
52ABL20.92624078
53TXK0.91790715
54PNCK0.91642903
55MAPK150.88653903
56TESK10.87613355
57DAPK30.83653564
58DYRK20.83138932
59PINK10.82333199
60PAK60.80838013
61CSNK1G30.80237292
62FGR0.79677948
63ADRBK10.79650609
64PAK10.79572042
65WNK30.78019385
66KDR0.77873640
67MAP3K20.77684164
68CAMK2D0.76570816
69MAPK130.75950354
70PKN10.75596970
71UHMK10.74835053
72CAMK2A0.74415986
73MAP3K140.74326146
74EIF2AK30.73811656
75TAOK10.73366094
76PTK2B0.72942404
77MAP3K40.72223790
78CAMKK20.71930909
79DAPK20.70770326
80CDK80.69801592
81TSSK60.69634423
82GRK60.69602058
83IRAK30.68137191
84ZAK0.66861313
85LRRK20.66238384
86CAMK2G0.65126370
87DDR20.64611508
88TBK10.64506781
89MINK10.64374519
90PRKG20.64036434
91PRKCE0.62166523
92DYRK30.61972828
93MAP3K130.61783840
94PAK40.61742425
95GRK10.60996786
96MAP3K90.58735979
97MAP2K60.57800101
98FES0.56829005
99NTRK10.56745162
100PHKG10.56724027
101PHKG20.56724027
102MOS0.56632925
103MAPKAPK30.55993668
104IKBKB0.55417581
105IRAK10.53755103
106CDK150.52784410
107MARK30.52608354
108LYN0.52501182
109CSNK2A10.52031782
110SRPK10.51925467
111TEC0.50963653
112INSRR0.47681165
113MAP2K20.46982530
114EPHA40.45716691
115MAP3K30.45338499
116CLK10.44793925
117AURKA0.44593541
118KIT0.43998561
119ILK0.43816675
120PRKCD0.42438314
121PRKCG0.42434046
122CDK140.42408840
123RPS6KA50.42155124
124CSNK2A20.42031634
125MAP2K40.42024980
126CSNK1G20.41501630
127EPHB20.40547519
128MAP3K50.40390506
129TYK20.40367709
130IRAK20.39996118
131PRKACA0.39848464
132LCK0.39756562
133IKBKE0.38250881
134YES10.38174656
135PRKCI0.38012186
136MARK10.37266052
137MAP3K110.37165096
138CDK50.36984869
139TNK20.36718289
140CDK11A0.36400508
141NUAK10.36231006
142RAF10.36222067
143MST1R0.36110749
144CDK180.35156910
145PIK3CG0.34204545

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.07100372
2Parkinsons disease_Homo sapiens_hsa050125.01767125
3Ribosome_Homo sapiens_hsa030103.92701178
4Alzheimers disease_Homo sapiens_hsa050103.91553176
5Proteasome_Homo sapiens_hsa030503.48709395
6Huntingtons disease_Homo sapiens_hsa050163.47298325
7Protein export_Homo sapiens_hsa030603.29024701
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.11592450
9* Collecting duct acid secretion_Homo sapiens_hsa049662.88085439
10Cardiac muscle contraction_Homo sapiens_hsa042601.97015837
11* Vibrio cholerae infection_Homo sapiens_hsa051101.91751465
12RNA polymerase_Homo sapiens_hsa030201.91457776
13* Rheumatoid arthritis_Homo sapiens_hsa053231.79620262
14* Synaptic vesicle cycle_Homo sapiens_hsa047211.75268687
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70810044
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40551081
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34500708
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.34135627
19Graft-versus-host disease_Homo sapiens_hsa053321.31540647
20Nicotine addiction_Homo sapiens_hsa050331.31310913
21Folate biosynthesis_Homo sapiens_hsa007901.30726069
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24051214
23* Phagosome_Homo sapiens_hsa041451.18641759
24* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17990914
25Type I diabetes mellitus_Homo sapiens_hsa049401.15673627
26Serotonergic synapse_Homo sapiens_hsa047261.15064806
27Fatty acid elongation_Homo sapiens_hsa000621.07083281
28Allograft rejection_Homo sapiens_hsa053301.06210463
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03634031
30Sulfur metabolism_Homo sapiens_hsa009201.00177503
31Asthma_Homo sapiens_hsa053100.97511633
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95061358
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95037091
34Mismatch repair_Homo sapiens_hsa034300.94494355
35Pyrimidine metabolism_Homo sapiens_hsa002400.94452961
36Taste transduction_Homo sapiens_hsa047420.92499790
37African trypanosomiasis_Homo sapiens_hsa051430.92204915
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91141757
39Base excision repair_Homo sapiens_hsa034100.89720454
40Sulfur relay system_Homo sapiens_hsa041220.89303832
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87507088
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85662468
43Fructose and mannose metabolism_Homo sapiens_hsa000510.84379468
44DNA replication_Homo sapiens_hsa030300.81834173
45Autoimmune thyroid disease_Homo sapiens_hsa053200.80579481
46Homologous recombination_Homo sapiens_hsa034400.80557683
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80426632
48Carbon metabolism_Homo sapiens_hsa012000.79085114
49Regulation of autophagy_Homo sapiens_hsa041400.76827143
50GABAergic synapse_Homo sapiens_hsa047270.75389734
51Peroxisome_Homo sapiens_hsa041460.75269889
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74225025
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.73456723
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73236687
55Lysosome_Homo sapiens_hsa041420.71123649
56Pentose phosphate pathway_Homo sapiens_hsa000300.68199485
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67742670
58Morphine addiction_Homo sapiens_hsa050320.67275747
59Phototransduction_Homo sapiens_hsa047440.65511991
60Amphetamine addiction_Homo sapiens_hsa050310.65229572
61Steroid biosynthesis_Homo sapiens_hsa001000.64438032
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64327369
63Circadian entrainment_Homo sapiens_hsa047130.61613770
64Galactose metabolism_Homo sapiens_hsa000520.61452552
65Ether lipid metabolism_Homo sapiens_hsa005650.61334492
66Dopaminergic synapse_Homo sapiens_hsa047280.58685100
67* Metabolic pathways_Homo sapiens_hsa011000.57650994
68Other glycan degradation_Homo sapiens_hsa005110.57334903
69Staphylococcus aureus infection_Homo sapiens_hsa051500.56582356
70Purine metabolism_Homo sapiens_hsa002300.56226575
71Pertussis_Homo sapiens_hsa051330.55686806
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55337259
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.53959236
74Arachidonic acid metabolism_Homo sapiens_hsa005900.53723503
75Cocaine addiction_Homo sapiens_hsa050300.52142724
76Tyrosine metabolism_Homo sapiens_hsa003500.51507875
77Glutamatergic synapse_Homo sapiens_hsa047240.50747603
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48325834
79Phenylalanine metabolism_Homo sapiens_hsa003600.47669525
80Long-term depression_Homo sapiens_hsa047300.46897267
81Sphingolipid metabolism_Homo sapiens_hsa006000.46682979
82Long-term potentiation_Homo sapiens_hsa047200.46411415
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46029337
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45761776
85Butanoate metabolism_Homo sapiens_hsa006500.45473279
86Shigellosis_Homo sapiens_hsa051310.45176990
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43981393
88Antigen processing and presentation_Homo sapiens_hsa046120.43155553
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42401237
90Tryptophan metabolism_Homo sapiens_hsa003800.42101416
91Insulin secretion_Homo sapiens_hsa049110.41527788
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41175117
93Vitamin B6 metabolism_Homo sapiens_hsa007500.40096391
94Cholinergic synapse_Homo sapiens_hsa047250.39522805
95Malaria_Homo sapiens_hsa051440.39402583
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39355051
97Biosynthesis of amino acids_Homo sapiens_hsa012300.39219146
98Tuberculosis_Homo sapiens_hsa051520.37413528
99Salmonella infection_Homo sapiens_hsa051320.36667562
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36547120
101Glutathione metabolism_Homo sapiens_hsa004800.35959091
102Hematopoietic cell lineage_Homo sapiens_hsa046400.35726408
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35500930
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35449044
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.35333472
106Renin secretion_Homo sapiens_hsa049240.34796585
107Prion diseases_Homo sapiens_hsa050200.34775682
108Salivary secretion_Homo sapiens_hsa049700.34497637
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33721005
110Epstein-Barr virus infection_Homo sapiens_hsa051690.33525645
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.33119221
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32981594
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32345917
114Histidine metabolism_Homo sapiens_hsa003400.32122931
115Calcium signaling pathway_Homo sapiens_hsa040200.31465148
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31191328
117Linoleic acid metabolism_Homo sapiens_hsa005910.30892728
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30064684
119Leishmaniasis_Homo sapiens_hsa051400.29967029
120Pyruvate metabolism_Homo sapiens_hsa006200.29776029
121Olfactory transduction_Homo sapiens_hsa047400.29245364
122Alcoholism_Homo sapiens_hsa050340.29156434
123Nucleotide excision repair_Homo sapiens_hsa034200.29122193
124Legionellosis_Homo sapiens_hsa051340.28730922
125Osteoclast differentiation_Homo sapiens_hsa043800.28664451
126Basal transcription factors_Homo sapiens_hsa030220.28557606
127Propanoate metabolism_Homo sapiens_hsa006400.27419706
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27366475
129N-Glycan biosynthesis_Homo sapiens_hsa005100.27010260
130RNA degradation_Homo sapiens_hsa030180.25760136
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25420462
132Mineral absorption_Homo sapiens_hsa049780.23969356
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23510238
134Spliceosome_Homo sapiens_hsa030400.22310925
135Gastric acid secretion_Homo sapiens_hsa049710.22085459
136Pancreatic secretion_Homo sapiens_hsa049720.22027921
137Primary immunodeficiency_Homo sapiens_hsa053400.21263082

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