ATP6V1G1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)7.96179183
2cytidine deamination (GO:0009972)7.84244432
3cytidine metabolic process (GO:0046087)7.84244432
4cytidine catabolic process (GO:0006216)7.84244432
5actin nucleation (GO:0045010)7.03555103
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.67346229
7DNA deamination (GO:0045006)6.37151784
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.19818873
9regulation of activation of Janus kinase activity (GO:0010533)5.58807648
10regulation of B cell receptor signaling pathway (GO:0050855)5.55050764
11negative regulation of B cell proliferation (GO:0030889)5.11565810
12negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)5.09874732
13regulation of chronic inflammatory response (GO:0002676)5.04918988
14eosinophil chemotaxis (GO:0048245)5.04793963
15regulation of chemokine-mediated signaling pathway (GO:0070099)5.00374884
16negative regulation of mast cell activation (GO:0033004)4.92045359
17positive thymic T cell selection (GO:0045059)4.82029514
18eosinophil migration (GO:0072677)4.57260512
19positive regulation of B cell differentiation (GO:0045579)4.25204899
20macrophage chemotaxis (GO:0048246)4.21748563
21protein neddylation (GO:0045116)4.19926321
22cellular response to interleukin-15 (GO:0071350)4.18804646
23positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.14167422
24positive T cell selection (GO:0043368)4.13279982
25positive regulation of natural killer cell mediated immunity (GO:0002717)4.01886991
26positive regulation of T cell chemotaxis (GO:0010820)3.99723760
27regulation of T cell chemotaxis (GO:0010819)3.99723760
28sequestering of actin monomers (GO:0042989)3.92287206
29negative regulation by host of viral transcription (GO:0043922)3.91178479
30negative regulation of T cell receptor signaling pathway (GO:0050860)3.83440725
31monocyte chemotaxis (GO:0002548)3.82391481
32negative regulation of T cell apoptotic process (GO:0070233)3.79222797
33regulation of alpha-beta T cell proliferation (GO:0046640)3.76375892
34positive regulation of monocyte chemotaxis (GO:0090026)3.68610231
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.64626625
36negative regulation of viral genome replication (GO:0045071)3.42563668
37regulation of T cell receptor signaling pathway (GO:0050856)3.40407266
38negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.39565946
39intestinal epithelial cell development (GO:0060576)3.39092054
40antigen processing and presentation via MHC class Ib (GO:0002475)3.38879659
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.38352098
42regulation of natural killer cell mediated immunity (GO:0002715)3.38352098
43positive regulation of translational initiation (GO:0045948)3.28445022
44regulation of regulatory T cell differentiation (GO:0045589)3.28299504
45regulation of lymphocyte chemotaxis (GO:1901623)3.27894676
46negative regulation of B cell activation (GO:0050869)3.24446932
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22865500
48negative regulation of oxidoreductase activity (GO:0051354)3.15532254
49regulation of B cell differentiation (GO:0045577)3.12174049
50regulation of mononuclear cell migration (GO:0071675)3.11484288
51positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.10764692
52pyrimidine nucleoside catabolic process (GO:0046135)3.08758092
53response to interleukin-15 (GO:0070672)3.02770713
54base-excision repair, AP site formation (GO:0006285)3.01234561
55regulation of glucocorticoid secretion (GO:2000849)2.98758909
56negative regulation of lymphocyte apoptotic process (GO:0070229)2.98662036
57T cell costimulation (GO:0031295)2.94083498
58positive regulation of interleukin-8 secretion (GO:2000484)2.94009394
59adaptation of signaling pathway (GO:0023058)2.93546879
60regulation of T cell tolerance induction (GO:0002664)2.90562655
61lymphocyte costimulation (GO:0031294)2.90511812
62iron-sulfur cluster assembly (GO:0016226)2.90410974
63metallo-sulfur cluster assembly (GO:0031163)2.90410974
64positive regulation of calcium-mediated signaling (GO:0050850)2.90076186
65positive regulation of cell killing (GO:0031343)2.89514988
66regulation of macrophage chemotaxis (GO:0010758)2.89324306
67purine ribonucleotide transport (GO:0015868)2.88557918
68thymic T cell selection (GO:0045061)2.88332680
69histone H2A acetylation (GO:0043968)2.87607508
70adenine nucleotide transport (GO:0051503)2.86703266
71response to pheromone (GO:0019236)2.86125864
72regulation of viral genome replication (GO:0045069)2.85225000
73carnitine metabolic process (GO:0009437)2.83971413
74T cell receptor signaling pathway (GO:0050852)2.78415488
75terpenoid biosynthetic process (GO:0016114)2.75043378
76behavioral response to nicotine (GO:0035095)2.69269034
77diterpenoid biosynthetic process (GO:0016102)2.69248242
78negative regulation of alpha-beta T cell activation (GO:0046636)2.69226867
79negative T cell selection (GO:0043383)2.68606863
80positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.67488474
81negative regulation of monooxygenase activity (GO:0032769)2.66479131
82amino-acid betaine metabolic process (GO:0006577)2.66365170
83dendritic cell migration (GO:0036336)2.64755992
84dendritic cell chemotaxis (GO:0002407)2.64038691
85positive regulation of defense response to virus by host (GO:0002230)2.62085692
86regulation of leukocyte mediated cytotoxicity (GO:0001910)2.61785593
87platelet dense granule organization (GO:0060155)2.59760202
88regulation of interleukin-8 secretion (GO:2000482)2.59674911
89mechanosensory behavior (GO:0007638)2.57033781
90positive regulation of protein homodimerization activity (GO:0090073)2.55128021
91antigen receptor-mediated signaling pathway (GO:0050851)2.51459262
92positive regulation of T cell apoptotic process (GO:0070234)2.50960779
93positive regulation of actin filament polymerization (GO:0030838)2.50849177
94T cell selection (GO:0045058)2.49268059
95establishment of protein localization to Golgi (GO:0072600)2.49158284
96positive regulation of gamma-delta T cell activation (GO:0046645)2.46287415
97regulation of cell killing (GO:0031341)2.46019297
98forebrain morphogenesis (GO:0048853)2.44947438
99regulation of isotype switching to IgG isotypes (GO:0048302)2.43779959
100neutrophil activation (GO:0042119)2.43166832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.31771136
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.78569335
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57141432
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.46612377
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.38490080
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17146602
7IGF1R_20145208_ChIP-Seq_DFB_Human2.97012277
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95946294
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.94605707
10VDR_22108803_ChIP-Seq_LS180_Human2.93919579
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.74873189
12TAF15_26573619_Chip-Seq_HEK293_Human2.61375270
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.11187245
14GABP_17652178_ChIP-ChIP_JURKAT_Human1.96036675
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.93600546
16TP53_22573176_ChIP-Seq_HFKS_Human1.90419761
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90047040
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88558263
19ZNF274_21170338_ChIP-Seq_K562_Hela1.85511153
20EZH2_22144423_ChIP-Seq_EOC_Human1.78949347
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78844376
22RUNX_20019798_ChIP-Seq_JUKART_Human1.77468305
23MYB_26560356_Chip-Seq_TH2_Human1.76341119
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75957847
25GATA3_26560356_Chip-Seq_TH2_Human1.73911609
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67996837
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.66010030
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.64534950
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62603003
30GATA3_27048872_Chip-Seq_THYMUS_Human1.59146549
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46178206
32EWS_26573619_Chip-Seq_HEK293_Human1.41664341
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41490312
34TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.41401007
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39936878
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38245582
37CIITA_25753668_ChIP-Seq_RAJI_Human1.36536266
38MYC_18940864_ChIP-ChIP_HL60_Human1.36043895
39NCOR_22424771_ChIP-Seq_293T_Human1.35684127
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35023377
41SOX2_19829295_ChIP-Seq_ESCs_Human1.33545012
42NANOG_19829295_ChIP-Seq_ESCs_Human1.33545012
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32203143
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.31779150
45ER_23166858_ChIP-Seq_MCF-7_Human1.27116889
46GATA3_26560356_Chip-Seq_TH1_Human1.26538971
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26147707
48AR_20517297_ChIP-Seq_VCAP_Human1.25719444
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25395665
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25138330
51FOXH1_21741376_ChIP-Seq_EPCs_Human1.22422096
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21446214
53TAF2_19829295_ChIP-Seq_ESCs_Human1.21384654
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.21206213
55GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.19709253
56FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19360332
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.18753725
58HTT_18923047_ChIP-ChIP_STHdh_Human1.18748877
59VDR_23849224_ChIP-Seq_CD4+_Human1.18100694
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17768631
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.17768631
62BCAT_22108803_ChIP-Seq_LS180_Human1.16774521
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15436925
64IRF1_19129219_ChIP-ChIP_H3396_Human1.14669779
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13665407
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13413096
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.12850313
68HOXB7_26014856_ChIP-Seq_BT474_Human1.09754144
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.09222702
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07232471
71MYC_19829295_ChIP-Seq_ESCs_Human1.06693278
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.04538296
73P300_19829295_ChIP-Seq_ESCs_Human1.04518923
74TCF4_22108803_ChIP-Seq_LS180_Human1.04383596
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04270304
76CBP_20019798_ChIP-Seq_JUKART_Human1.04270304
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03393985
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02181086
79BCL6_27268052_Chip-Seq_Bcells_Human1.01123841
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00723835
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00702292
82AR_25329375_ChIP-Seq_VCAP_Human0.98799628
83TP53_16413492_ChIP-PET_HCT116_Human0.97999298
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96830061
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96809626
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96505447
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.95919072
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.95688765
89GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95343203
90EGR1_19032775_ChIP-ChIP_M12_Human0.94646664
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.94392122
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94261077
93NANOG_20526341_ChIP-Seq_ESCs_Human0.94234712
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.93998982
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93631351
96FOXP3_21729870_ChIP-Seq_TREG_Human0.93498532
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91308656
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90633363
99P53_21459846_ChIP-Seq_SAOS-2_Human0.90061499
100ERG_20517297_ChIP-Seq_VCAP_Human0.89713636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.18579614
2MP0003011_delayed_dark_adaptation4.10314558
3MP0002638_abnormal_pupillary_reflex2.59613670
4MP0001800_abnormal_humoral_immune2.50243589
5MP0001873_stomach_inflammation2.46097881
6MP0003183_abnormal_peptide_metabolism2.41636170
7MP0004147_increased_porphyrin_level2.35573761
8MP0001968_abnormal_touch/_nociception2.31257408
9MP0003763_abnormal_thymus_physiology2.28010557
10MP0002723_abnormal_immune_serum2.10775016
11MP0009785_altered_susceptibility_to2.09175565
12MP0006292_abnormal_olfactory_placode2.05084377
13MP0005000_abnormal_immune_tolerance2.00626678
14MP0001835_abnormal_antigen_presentation1.91686189
15MP0006276_abnormal_autonomic_nervous1.90142225
16MP0009333_abnormal_splenocyte_physiolog1.89317113
17MP0006072_abnormal_retinal_apoptosis1.88867811
18MP0002138_abnormal_hepatobiliary_system1.85628049
19MP0005551_abnormal_eye_electrophysiolog1.77977148
20MP0002148_abnormal_hypersensitivity_rea1.70000827
21MP0005645_abnormal_hypothalamus_physiol1.69706732
22MP0002420_abnormal_adaptive_immunity1.68830294
23MP0009764_decreased_sensitivity_to1.68436634
24MP0001819_abnormal_immune_cell1.65266930
25MP0005253_abnormal_eye_physiology1.64455561
26MP0002452_abnormal_antigen_presenting1.62457697
27MP0002933_joint_inflammation1.62221964
28MP0010155_abnormal_intestine_physiology1.58786859
29MP0000013_abnormal_adipose_tissue1.58383789
30MP0000372_irregular_coat_pigmentation1.52808153
31MP0002166_altered_tumor_susceptibility1.52173896
32MP0003283_abnormal_digestive_organ1.41713850
33MP0001188_hyperpigmentation1.40059399
34MP0002736_abnormal_nociception_after1.40037246
35MP0002163_abnormal_gland_morphology1.37043987
36MP0003195_calcinosis1.36945439
37MP0005451_abnormal_body_composition1.36752197
38MP0009046_muscle_twitch1.32555700
39MP0000716_abnormal_immune_system1.30362098
40MP0002822_catalepsy1.29510650
41MP0001485_abnormal_pinna_reflex1.29328125
42MP0003567_abnormal_fetal_cardiomyocyte1.27852302
43MP0002398_abnormal_bone_marrow1.27064963
44MP0001984_abnormal_olfaction1.23342260
45MP0002405_respiratory_system_inflammati1.23264155
46MP0002102_abnormal_ear_morphology1.22623904
47MP0001845_abnormal_inflammatory_respons1.20632923
48MP0008007_abnormal_cellular_replicative1.20512030
49MP0002234_abnormal_pharynx_morphology1.19152299
50MP0002006_tumorigenesis1.17133072
51MP0005084_abnormal_gallbladder_morpholo1.16771795
52MP0005387_immune_system_phenotype1.14496744
53MP0001790_abnormal_immune_system1.14496744
54MP0000689_abnormal_spleen_morphology1.12347764
55MP0003786_premature_aging1.12135902
56MP0002009_preneoplasia1.12101169
57MP0000685_abnormal_immune_system1.11600877
58MP0001919_abnormal_reproductive_system1.10257542
59MP0005025_abnormal_response_to1.10044214
60MP0009745_abnormal_behavioral_response1.08345281
61MP0005379_endocrine/exocrine_gland_phen1.03748259
62MP0001853_heart_inflammation1.03497934
63MP0001986_abnormal_taste_sensitivity1.03346962
64MP0001905_abnormal_dopamine_level1.02033303
65MP0004043_abnormal_pH_regulation1.01639416
66MP0004742_abnormal_vestibular_system0.98357163
67MP0008877_abnormal_DNA_methylation0.97473155
68MP0008872_abnormal_physiological_respon0.96813108
69MP0005389_reproductive_system_phenotype0.93920276
70MP0003866_abnormal_defecation0.92021220
71MP0010386_abnormal_urinary_bladder0.91139422
72MP0002429_abnormal_blood_cell0.90872811
73MP0009765_abnormal_xenobiotic_induced0.90553379
74MP0003880_abnormal_central_pattern0.90153933
75MP0008873_increased_physiological_sensi0.88005932
76MP0005646_abnormal_pituitary_gland0.86508895
77MP0005167_abnormal_blood-brain_barrier0.85734206
78MP0002909_abnormal_adrenal_gland0.84115451
79MP0002722_abnormal_immune_system0.82829781
80MP0001501_abnormal_sleep_pattern0.81329591
81MP0004133_heterotaxia0.78005866
82MP0008260_abnormal_autophagy0.77275328
83MP0009643_abnormal_urine_homeostasis0.77178275
84MP0002928_abnormal_bile_duct0.77167899
85MP0003806_abnormal_nucleotide_metabolis0.76857923
86MP0002733_abnormal_thermal_nociception0.73611342
87MP0001661_extended_life_span0.72973191
88MP0004145_abnormal_muscle_electrophysio0.72773797
89MP0000703_abnormal_thymus_morphology0.72767666
90MP0003075_altered_response_to0.72473879
91MP0002064_seizures0.71751539
92MP0006082_CNS_inflammation0.71135675
93MP0003938_abnormal_ear_development0.70977256
94MP0008469_abnormal_protein_level0.70860694
95MP0002019_abnormal_tumor_incidence0.70608334
96MP0002160_abnormal_reproductive_system0.67920339
97MP0003045_fibrosis0.67665427
98MP0002557_abnormal_social/conspecific_i0.67596770
99MP0000639_abnormal_adrenal_gland0.66997860
100MP0002693_abnormal_pancreas_physiology0.66377012

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)5.46614668
2T lymphocytopenia (HP:0005403)5.12703196
3Abnormality of T cell number (HP:0011839)5.11450982
4Thyroiditis (HP:0100646)4.52786031
5Severe combined immunodeficiency (HP:0004430)4.24512550
6IgG deficiency (HP:0004315)4.16986826
7Abnormality of B cell number (HP:0010975)3.84255983
8Hypoproteinemia (HP:0003075)3.81155980
9Stomatitis (HP:0010280)3.70932939
10Abnormality of eosinophils (HP:0001879)3.62200638
11Keratoconus (HP:0000563)3.59489051
12Increased corneal curvature (HP:0100692)3.59489051
13Abnormality of the prostate (HP:0008775)3.36711468
14Combined immunodeficiency (HP:0005387)3.33968182
15Gastrointestinal infarctions (HP:0005244)3.21317371
16Elevated erythrocyte sedimentation rate (HP:0003565)3.20290991
17B lymphocytopenia (HP:0010976)3.14369409
18Abolished electroretinogram (ERG) (HP:0000550)3.12848168
19Dysautonomia (HP:0002459)3.08471192
20Congenital stationary night blindness (HP:0007642)3.04691551
21Agammaglobulinemia (HP:0004432)3.02895997
22Autoimmune hemolytic anemia (HP:0001890)2.99731221
23Acute necrotizing encephalopathy (HP:0006965)2.97621482
24Stomach cancer (HP:0012126)2.96903310
25Pendular nystagmus (HP:0012043)2.89447503
26Progressive macrocephaly (HP:0004481)2.85373374
27Abnormality of T cells (HP:0002843)2.75817983
28Focal motor seizures (HP:0011153)2.74988903
29Abnormal mitochondria in muscle tissue (HP:0008316)2.74635102
30Hypoplasia of the thymus (HP:0000778)2.62883246
31Decreased central vision (HP:0007663)2.58934355
32Eosinophilia (HP:0001880)2.58341811
33Recurrent bronchitis (HP:0002837)2.57378363
34Clumsiness (HP:0002312)2.57376863
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.57057250
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.57057250
37Leukocytosis (HP:0001974)2.54331641
38Hypoglycemic seizures (HP:0002173)2.53754929
393-Methylglutaconic aciduria (HP:0003535)2.51999143
40Abnormal rod and cone electroretinograms (HP:0008323)2.49205825
41Lymphopenia (HP:0001888)2.40688694
42Recurrent cutaneous fungal infections (HP:0011370)2.39084507
43Chronic mucocutaneous candidiasis (HP:0002728)2.39084507
44Abnormality of binocular vision (HP:0011514)2.35299676
45Diplopia (HP:0000651)2.35299676
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.34138533
47Hypoalbuminemia (HP:0003073)2.34062874
48Abnormal albumin level (HP:0012116)2.34062874
49Ureteral stenosis (HP:0000071)2.31857711
50Visual hallucinations (HP:0002367)2.31751194
51Pulmonary infiltrates (HP:0002113)2.29401074
52Chronic diarrhea (HP:0002028)2.28190626
53Severe visual impairment (HP:0001141)2.27515468
54Orthostatic hypotension (HP:0001278)2.25765379
55Mitochondrial inheritance (HP:0001427)2.24998506
56Absent thumb (HP:0009777)2.24419171
57Ureteral obstruction (HP:0006000)2.20303837
58Attenuation of retinal blood vessels (HP:0007843)2.19589050
59Abnormality of the pleura (HP:0002103)2.19323791
60Amyotrophic lateral sclerosis (HP:0007354)2.15219336
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14564103
62Acute encephalopathy (HP:0006846)2.13227842
63Pancreatic cysts (HP:0001737)2.13143235
64Abnormality of male internal genitalia (HP:0000022)2.11878695
65Encephalitis (HP:0002383)2.08530900
66Meningitis (HP:0001287)2.04334364
67Abnormality of fatty-acid metabolism (HP:0004359)2.02836454
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02602813
69Aplastic anemia (HP:0001915)2.02483028
70Clubbing of toes (HP:0100760)2.01628948
71Hypergammaglobulinemia (HP:0010702)2.00282990
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99343781
73Increased CSF lactate (HP:0002490)1.98550951
74Recurrent otitis media (HP:0000403)1.95584226
75Polydipsia (HP:0001959)1.94980698
76Abnormal drinking behavior (HP:0030082)1.94980698
77Conical tooth (HP:0000698)1.89749598
78Optic disc pallor (HP:0000543)1.89721243
79Agitation (HP:0000713)1.88865841
80J-shaped sella turcica (HP:0002680)1.87619345
81Renal cortical cysts (HP:0000803)1.87601600
82Radial bowing (HP:0002986)1.87118005
83Vasculitis (HP:0002633)1.87070528
84Hypoplasia of the fovea (HP:0007750)1.86128823
85Aplasia/Hypoplasia of the fovea (HP:0008060)1.86128823
86Gangrene (HP:0100758)1.85460508
87Skin rash (HP:0000988)1.84893258
88Delayed CNS myelination (HP:0002188)1.84453203
89Granulocytopenia (HP:0001913)1.82736539
90Pancreatic fibrosis (HP:0100732)1.82705987
91Carpal bone hypoplasia (HP:0001498)1.82148880
92Methylmalonic acidemia (HP:0002912)1.81736506
93True hermaphroditism (HP:0010459)1.81456157
94Chorioretinal atrophy (HP:0000533)1.80762012
95Bronchitis (HP:0012387)1.74319092
96Periorbital edema (HP:0100539)1.73449219
97Hemiplegia (HP:0002301)1.72658168
98Obstructive lung disease (HP:0006536)1.72430910
99Chronic obstructive pulmonary disease (HP:0006510)1.72430910
100Hypothermia (HP:0002045)1.69949500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.31657363
2KDR4.91797012
3FRK2.95197354
4GRK12.59774798
5ADRBK22.49595342
6TESK22.29263416
7TRIM282.27692929
8ZAK2.21628271
9IRAK12.02682914
10MAP4K22.02637432
11ITK2.00849702
12BCKDK1.95550736
13TAOK31.85735825
14CDK191.78755479
15MATK1.76112877
16SYK1.75941098
17IRAK21.59422983
18TEC1.58169514
19INSRR1.53934403
20EPHA31.47560610
21CAMKK21.47403093
22WNK41.37798640
23TIE11.36134079
24MAPKAPK31.34069190
25NTRK11.31699368
26TBK11.27266508
27IKBKE1.23219269
28TRPM71.22021119
29FES1.21948976
30PINK11.19507437
31MAP4K11.16374435
32GRK61.13051150
33IKBKB1.12899464
34BTK1.08287158
35PRKCQ0.97809700
36MST40.96897324
37PASK0.86938955
38CHUK0.85166071
39WNK30.82444863
40PRKCE0.81986550
41CDK40.79918248
42BMPR20.79862572
43PRKD30.78753105
44MAPK130.77951298
45RPS6KA50.77520902
46CSK0.77385891
47MAP3K110.70477874
48FGFR20.68663654
49LCK0.67400495
50PTK2B0.66474338
51PLK20.66091042
52STK160.62261481
53EIF2AK30.61120967
54MAP3K90.60850481
55ERBB30.60231590
56LYN0.60046344
57ROCK10.58274106
58PRKCG0.58216849
59CAMKK10.56290277
60ADRBK10.55573754
61EPHB10.53691375
62PRKCH0.53334868
63PRKACA0.51762271
64OBSCN0.51269063
65CCNB10.50961098
66PRKCA0.50281077
67GRK50.48513749
68CSNK1G10.48403729
69CSF1R0.47814546
70MAPK110.47665259
71CDK80.47418780
72CDK90.47361321
73ABL10.47245083
74CAMK2A0.47209452
75IGF1R0.45856729
76TLK10.45366224
77TYRO30.45362718
78EPHA40.45124677
79SCYL20.44037239
80SRPK10.43158346
81ZAP700.41330753
82PRKD20.41039920
83MAPKAPK20.40031389
84MUSK0.40005973
85BCR0.39933250
86MAP2K20.39502113
87AURKA0.38222425
88PHKG10.37837128
89PHKG20.37837128
90DYRK20.37105924
91PKN10.36231207
92ERBB20.35574635
93HCK0.35141991
94OXSR10.34712208
95RPS6KA40.34350194
96MAP3K40.33802763
97INSR0.33444429
98FYN0.32778267
99CAMK10.32534750
100MYLK0.32231434

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.31222307
2Graft-versus-host disease_Homo sapiens_hsa053323.47617793
3Autoimmune thyroid disease_Homo sapiens_hsa053203.43554880
4Proteasome_Homo sapiens_hsa030503.16199706
5Allograft rejection_Homo sapiens_hsa053303.15720772
6Antigen processing and presentation_Homo sapiens_hsa046122.78124250
7Type I diabetes mellitus_Homo sapiens_hsa049402.60100352
8Phototransduction_Homo sapiens_hsa047442.57898380
9Asthma_Homo sapiens_hsa053102.57479703
10Hematopoietic cell lineage_Homo sapiens_hsa046402.52620358
11Regulation of autophagy_Homo sapiens_hsa041402.27189409
12Oxidative phosphorylation_Homo sapiens_hsa001902.25186168
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.22978401
14Rheumatoid arthritis_Homo sapiens_hsa053231.96573297
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89733908
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89133555
17Protein export_Homo sapiens_hsa030601.85077349
18Homologous recombination_Homo sapiens_hsa034401.79637493
19T cell receptor signaling pathway_Homo sapiens_hsa046601.68332987
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55552504
21Linoleic acid metabolism_Homo sapiens_hsa005911.53341693
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46914283
23Parkinsons disease_Homo sapiens_hsa050121.46138042
24Non-homologous end-joining_Homo sapiens_hsa034501.45646143
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45107249
26Ether lipid metabolism_Homo sapiens_hsa005651.43477296
27Selenocompound metabolism_Homo sapiens_hsa004501.41430988
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39424750
29Viral myocarditis_Homo sapiens_hsa054161.39096117
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27031694
31Fanconi anemia pathway_Homo sapiens_hsa034601.21361312
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.18071405
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15256390
34Shigellosis_Homo sapiens_hsa051311.09361051
35Collecting duct acid secretion_Homo sapiens_hsa049661.05736274
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04979476
37Olfactory transduction_Homo sapiens_hsa047401.03682763
38Systemic lupus erythematosus_Homo sapiens_hsa053220.97875825
39Butanoate metabolism_Homo sapiens_hsa006500.97435606
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96589993
41Alzheimers disease_Homo sapiens_hsa050100.95881292
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95609061
43Nitrogen metabolism_Homo sapiens_hsa009100.93482031
44Peroxisome_Homo sapiens_hsa041460.89115040
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88410709
46Salmonella infection_Homo sapiens_hsa051320.87417006
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86568956
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84268360
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84249759
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78485572
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.74787859
52Taste transduction_Homo sapiens_hsa047420.74375800
53Staphylococcus aureus infection_Homo sapiens_hsa051500.73390086
54Morphine addiction_Homo sapiens_hsa050320.73287991
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69394997
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.68589034
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65618627
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65576298
59Retinol metabolism_Homo sapiens_hsa008300.63693464
60Propanoate metabolism_Homo sapiens_hsa006400.61588646
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60041348
62Chemokine signaling pathway_Homo sapiens_hsa040620.57904126
63Huntingtons disease_Homo sapiens_hsa050160.56735148
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55539861
65Measles_Homo sapiens_hsa051620.53617320
66African trypanosomiasis_Homo sapiens_hsa051430.51680223
67Cardiac muscle contraction_Homo sapiens_hsa042600.51086215
68RNA degradation_Homo sapiens_hsa030180.50520619
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48648271
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47866077
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47614577
72Fat digestion and absorption_Homo sapiens_hsa049750.45514255
73Arachidonic acid metabolism_Homo sapiens_hsa005900.43349431
74Pyrimidine metabolism_Homo sapiens_hsa002400.41777917
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41151214
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.40860950
77Mismatch repair_Homo sapiens_hsa034300.40743309
78Alcoholism_Homo sapiens_hsa050340.38070224
79Malaria_Homo sapiens_hsa051440.37988786
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34921434
81Prion diseases_Homo sapiens_hsa050200.34593950
82Herpes simplex infection_Homo sapiens_hsa051680.34089351
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34054854
84Phagosome_Homo sapiens_hsa041450.33265881
85Chemical carcinogenesis_Homo sapiens_hsa052040.32363560
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32197981
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31811123
88GABAergic synapse_Homo sapiens_hsa047270.31308878
89Leishmaniasis_Homo sapiens_hsa051400.30329610
90RNA polymerase_Homo sapiens_hsa030200.29812066
91Serotonergic synapse_Homo sapiens_hsa047260.27701974
92Dorso-ventral axis formation_Homo sapiens_hsa043200.27095114
93Circadian entrainment_Homo sapiens_hsa047130.24051625
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.22618310
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22515333
96Nicotine addiction_Homo sapiens_hsa050330.22250476
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19473092
98Purine metabolism_Homo sapiens_hsa002300.19251526
99Glutamatergic synapse_Homo sapiens_hsa047240.15266254
100Metabolic pathways_Homo sapiens_hsa011000.12070916

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