ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.07949785
2	DNA double-strand break processing (GO:0000729)	4.03492507
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.02280641
4	platelet dense granule organization (GO:0060155)	3.93660332
5	detection of light stimulus involved in visual perception (GO:0050908)	3.84445906
6	detection of light stimulus involved in sensory perception (GO:0050962)	3.84445906
7	signal peptide processing (GO:0006465)	3.83216981
8	presynaptic membrane assembly (GO:0097105)	3.69041546
9	establishment of protein localization to Golgi (GO:0072600)	3.52743557
10	protein K11-linked deubiquitination (GO:0035871)	3.50565766
11	L-fucose catabolic process (GO:0042355)	3.50079980
12	fucose catabolic process (GO:0019317)	3.50079980
13	L-fucose metabolic process (GO:0042354)	3.50079980
14	C4-dicarboxylate transport (GO:0015740)	3.44215089
15	retinal cone cell development (GO:0046549)	3.43957636
16	intraciliary transport (GO:0042073)	3.41640445
17	replication fork processing (GO:0031297)	3.38092759
18	regulation of cilium movement (GO:0003352)	3.37694756
19	protein targeting to Golgi (GO:0000042)	3.37009603
20	proline transport (GO:0015824)	3.33785025
21	proteasome assembly (GO:0043248)	3.29085361
22	protein prenylation (GO:0018342)	3.27929101
23	prenylation (GO:0097354)	3.27929101
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.17766848
25	presynaptic membrane organization (GO:0097090)	3.17671371
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.15152999
27	inner ear receptor stereocilium organization (GO:0060122)	3.09689367
28	photoreceptor cell maintenance (GO:0045494)	3.08245131
29	cilium morphogenesis (GO:0060271)	3.08029722
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.01536920
31	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.00348038
32	cyclic nucleotide catabolic process (GO:0009214)	2.98737195
33	cullin deneddylation (GO:0010388)	2.98462940
34	branched-chain amino acid catabolic process (GO:0009083)	2.98265601
35	mannosylation (GO:0097502)	2.90391817
36	photoreceptor cell development (GO:0042461)	2.89878506
37	auditory receptor cell stereocilium organization (GO:0060088)	2.88065357
38	cellular response to sterol (GO:0036315)	2.87736945
39	protein localization to Golgi apparatus (GO:0034067)	2.85782136
40	nonmotile primary cilium assembly (GO:0035058)	2.85417534
41	nucleobase catabolic process (GO:0046113)	2.83382379
42	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.82422377
43	preassembly of GPI anchor in ER membrane (GO:0016254)	2.80509036
44	neuronal action potential propagation (GO:0019227)	2.80494899
45	positive regulation of protein autophosphorylation (GO:0031954)	2.79504305
46	eye photoreceptor cell development (GO:0042462)	2.76782889
47	cilium assembly (GO:0042384)	2.73590678
48	cAMP catabolic process (GO:0006198)	2.73199431
49	cilium organization (GO:0044782)	2.72281307
50	axoneme assembly (GO:0035082)	2.71662863
51	alanine transport (GO:0032328)	2.66493949
52	cell wall macromolecule catabolic process (GO:0016998)	2.66465850
53	inositol phosphate catabolic process (GO:0071545)	2.66332197
54	regulation of glucokinase activity (GO:0033131)	2.65074123
55	regulation of hexokinase activity (GO:1903299)	2.65074123
56	epithelial cilium movement (GO:0003351)	2.64659931
57	fatty acid elongation (GO:0030497)	2.64426483
58	multicellular organism reproduction (GO:0032504)	2.58878324
59	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.58715450
60	protein deneddylation (GO:0000338)	2.55927397
61	respiratory chain complex IV assembly (GO:0008535)	2.54010599
62	xenobiotic catabolic process (GO:0042178)	2.53818037
63	behavioral response to ethanol (GO:0048149)	2.53496048
64	polyol catabolic process (GO:0046174)	2.51108821
65	recombinational repair (GO:0000725)	2.50559674
66	C-terminal protein lipidation (GO:0006501)	2.49216670
67	histone H2A acetylation (GO:0043968)	2.48672728
68	adenosine metabolic process (GO:0046085)	2.48157811
69	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.47080337
70	lipid particle organization (GO:0034389)	2.46237143
71	glycosphingolipid biosynthetic process (GO:0006688)	2.46035416
72	piRNA metabolic process (GO:0034587)	2.43737836
73	neural tube formation (GO:0001841)	2.43512252
74	regulation of protein glycosylation (GO:0060049)	2.43346739
75	double-strand break repair via homologous recombination (GO:0000724)	2.42722284
76	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.42480971
77	inositol phosphate dephosphorylation (GO:0046855)	2.42480971
78	microtubule anchoring (GO:0034453)	2.41819639
79	positive regulation of amino acid transport (GO:0051957)	2.41519675
80	cellular ketone body metabolic process (GO:0046950)	2.41515202
81	regulation of protein kinase A signaling (GO:0010738)	2.41198624
82	GPI anchor metabolic process (GO:0006505)	2.40971487
83	olfactory bulb development (GO:0021772)	2.38763619
84	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.38085027
85	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.37613689
86	acrosome reaction (GO:0007340)	2.37326227
87	acrosome assembly (GO:0001675)	2.36757467
88	S-adenosylmethionine metabolic process (GO:0046500)	2.35842562
89	anterograde synaptic vesicle transport (GO:0048490)	2.35372973
90	lactate metabolic process (GO:0006089)	2.35195016
91	phospholipid homeostasis (GO:0055091)	2.32207522
92	protein-cofactor linkage (GO:0018065)	2.31781453
93	ketone body metabolic process (GO:1902224)	2.31171282
94	transepithelial transport (GO:0070633)	2.30970385
95	positive regulation of glycolytic process (GO:0045821)	2.30374759
96	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.29901672
97	resolution of meiotic recombination intermediates (GO:0000712)	2.28901371
98	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.28861284
99	DNA integration (GO:0015074)	2.28067294
100	negative regulation of axon guidance (GO:1902668)	2.26664152

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.44761950
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.17032452
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.15855972
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.95967854
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.81375976
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.66170541
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.66085803
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.62663662
9	VDR_22108803_ChIP-Seq_LS180_Human	2.62152504
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.54103522
11	FUS_26573619_Chip-Seq_HEK293_Human	2.53111346
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.38985502
13	P300_19829295_ChIP-Seq_ESCs_Human	2.36927060
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30805760
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.08936510
16	EWS_26573619_Chip-Seq_HEK293_Human	2.00326658
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.95322624
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94117741
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89970318
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.87204399
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.87194941
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.86600382
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.84254368
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80564851
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78896388
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78463626
27	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.74716896
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69764386
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.69764386
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69140287
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65839039
32	AR_25329375_ChIP-Seq_VCAP_Human	1.64698748
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64551192
34	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63192803
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62994841
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60869119
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56688572
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55097220
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54544771
40	STAT3_23295773_ChIP-Seq_U87_Human	1.54506253
41	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.52996113
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51620836
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50768723
44	TCF4_23295773_ChIP-Seq_U87_Human	1.47609548
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47332754
46	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45919038
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45897795
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.43275450
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.43249569
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36278810
51	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.36232202
52	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.35439467
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35199628
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.31922224
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30557003
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29996284
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29606772
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29192387
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29192387
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29139895
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.27521704
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25368563
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25019329
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24178279
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.23638015
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.20732836
67	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.20430218
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20186130
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.20123076
70	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19893587
71	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19595589
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18467632
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17926449
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17684292
75	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.14535627
76	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.13540756
77	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.12883972
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11892164
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11623953
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11623953
81	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.09110044
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08821761
83	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08714751
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08416223
85	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07900347
86	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07414470
87	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05371323
88	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04581084
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04350719
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04328054
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03591379
92	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.02405373
93	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.02405373
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01869780
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01869780
96	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.00295258
97	EZH2_22144423_ChIP-Seq_EOC_Human	0.98716024
98	JUN_21703547_ChIP-Seq_K562_Human	0.97656107
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96860477
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96698153

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.47371846
2	MP0000372_irregular_coat_pigmentation	3.11082522
3	MP0006054_spinal_hemorrhage	2.71052707
4	MP0005551_abnormal_eye_electrophysiolog	2.65286830
5	MP0008877_abnormal_DNA_methylation	2.63484362
6	MP0003011_delayed_dark_adaptation	2.42927114
7	MP0006072_abnormal_retinal_apoptosis	2.39716428
8	MP0005253_abnormal_eye_physiology	2.34366563
9	MP0001984_abnormal_olfaction	2.15478608
10	MP0002837_dystrophic_cardiac_calcinosis	2.12933217
11	MP0002102_abnormal_ear_morphology	2.08925649
12	MP0001986_abnormal_taste_sensitivity	2.08667603
13	MP0002638_abnormal_pupillary_reflex	2.07002372
14	MP0003880_abnormal_central_pattern	1.94856351
15	MP0002736_abnormal_nociception_after	1.94617896
16	MP0003718_maternal_effect	1.89431621
17	MP0004147_increased_porphyrin_level	1.85187028
18	MP0003787_abnormal_imprinting	1.84938111
19	MP0005646_abnormal_pituitary_gland	1.83551006
20	MP0005187_abnormal_penis_morphology	1.77595718
21	MP0003136_yellow_coat_color	1.76989091
22	MP0002938_white_spotting	1.74569692
23	MP0001968_abnormal_touch/_nociception	1.74185113
24	MP0005367_renal/urinary_system_phenotyp	1.71664442
25	MP0000516_abnormal_urinary_system	1.71664442
26	MP0008058_abnormal_DNA_repair	1.71580037
27	MP0001486_abnormal_startle_reflex	1.65472249
28	MP0009046_muscle_twitch	1.58089750
29	MP0005084_abnormal_gallbladder_morpholo	1.57765038
30	MP0000427_abnormal_hair_cycle	1.56359472
31	MP0004215_abnormal_myocardial_fiber	1.52794206
32	MP0002234_abnormal_pharynx_morphology	1.50534298
33	MP0005174_abnormal_tail_pigmentation	1.46962936
34	MP0001764_abnormal_homeostasis	1.46479192
35	MP0004043_abnormal_pH_regulation	1.35576722
36	MP0005248_abnormal_Harderian_gland	1.34012693
37	MP0008789_abnormal_olfactory_epithelium	1.30179869
38	MP0009745_abnormal_behavioral_response	1.29187220
39	MP0003950_abnormal_plasma_membrane	1.28958092
40	MP0002272_abnormal_nervous_system	1.26296259
41	MP0008875_abnormal_xenobiotic_pharmacok	1.26096964
42	MP0005171_absent_coat_pigmentation	1.25417186
43	MP0008872_abnormal_physiological_respon	1.25147558
44	MP0004885_abnormal_endolymph	1.24291809
45	MP0005408_hypopigmentation	1.23676699
46	MP0002557_abnormal_social/conspecific_i	1.23481717
47	MP0005410_abnormal_fertilization	1.23030187
48	MP0009697_abnormal_copulation	1.22426468
49	MP0003186_abnormal_redox_activity	1.21553343
50	MP0002160_abnormal_reproductive_system	1.20982571
51	MP0000647_abnormal_sebaceous_gland	1.18805527
52	MP0001529_abnormal_vocalization	1.17311015
53	MP0005645_abnormal_hypothalamus_physiol	1.16954795
54	MP0001485_abnormal_pinna_reflex	1.15532474
55	MP0002138_abnormal_hepatobiliary_system	1.13418459
56	MP0001501_abnormal_sleep_pattern	1.12784603
57	MP0005379_endocrine/exocrine_gland_phen	1.11204764
58	MP0004270_analgesia	1.09368946
59	MP0005389_reproductive_system_phenotype	1.07462380
60	MP0005647_abnormal_sex_gland	1.06982672
61	MP0002751_abnormal_autonomic_nervous	1.06035173
62	MP0002090_abnormal_vision	1.05659087
63	MP0002067_abnormal_sensory_capabilities	1.05300080
64	MP0004742_abnormal_vestibular_system	1.03469648
65	MP0002876_abnormal_thyroid_physiology	1.02299244
66	MP0005167_abnormal_blood-brain_barrier	1.01240169
67	MP0005195_abnormal_posterior_eye	1.00881481
68	MP0005395_other_phenotype	0.99589683
69	MP0002735_abnormal_chemical_nociception	0.99450658
70	MP0002734_abnormal_mechanical_nocicepti	0.98991620
71	MP0004484_altered_response_of	0.98293662
72	MP0002572_abnormal_emotion/affect_behav	0.97050562
73	MP0000778_abnormal_nervous_system	0.96307932
74	MP0008775_abnormal_heart_ventricle	0.95927233
75	MP0001929_abnormal_gametogenesis	0.95109377
76	MP0006276_abnormal_autonomic_nervous	0.94795746
77	MP0003698_abnormal_male_reproductive	0.94707488
78	MP0000015_abnormal_ear_pigmentation	0.94522519
79	MP0010329_abnormal_lipoprotein_level	0.93307373
80	MP0004142_abnormal_muscle_tone	0.92254754
81	MP0003121_genomic_imprinting	0.91832814
82	MP0000538_abnormal_urinary_bladder	0.91077721
83	MP0003119_abnormal_digestive_system	0.90976773
84	MP0010386_abnormal_urinary_bladder	0.87862421
85	MP0005391_vision/eye_phenotype	0.87764563
86	MP0000631_abnormal_neuroendocrine_gland	0.87304022
87	MP0005394_taste/olfaction_phenotype	0.85986357
88	MP0005499_abnormal_olfactory_system	0.85986357
89	MP0004924_abnormal_behavior	0.85493803
90	MP0005386_behavior/neurological_phenoty	0.85493803
91	MP0003137_abnormal_impulse_conducting	0.85259962
92	MP0000569_abnormal_digit_pigmentation	0.84526242
93	MP0001324_abnormal_eye_pigmentation	0.84511929
94	MP0004085_abnormal_heartbeat	0.84398507
95	MP0001970_abnormal_pain_threshold	0.81637030
96	MP0010368_abnormal_lymphatic_system	0.81428124
97	MP0002229_neurodegeneration	0.80162462
98	MP0002752_abnormal_somatic_nervous	0.78129443
99	MP0010094_abnormal_chromosome_stability	0.77752861
100	MP0000026_abnormal_inner_ear	0.76209317

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.25873499
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.03192641
3	Hypoplasia of the fovea (HP:0007750)	4.03192641
4	True hermaphroditism (HP:0010459)	3.85830301
5	Pancreatic cysts (HP:0001737)	3.79168124
6	Pancreatic fibrosis (HP:0100732)	3.74509942
7	Molar tooth sign on MRI (HP:0002419)	3.69460322
8	Abnormality of midbrain morphology (HP:0002418)	3.69460322
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.64686208
10	Abnormality of the fovea (HP:0000493)	3.40355903
11	Medial flaring of the eyebrow (HP:0010747)	3.36850042
12	Abnormality of macular pigmentation (HP:0008002)	3.18423535
13	Renal cortical cysts (HP:0000803)	3.14067212
14	Abnormality of the renal cortex (HP:0011035)	3.05872257
15	Nephronophthisis (HP:0000090)	2.92422731
16	Severe visual impairment (HP:0001141)	2.86898900
17	Intestinal atresia (HP:0011100)	2.86203334
18	Congenital primary aphakia (HP:0007707)	2.79300164
19	Albinism (HP:0001022)	2.78908442
20	Gait imbalance (HP:0002141)	2.77490430
21	Chronic hepatic failure (HP:0100626)	2.74026635
22	Hyperventilation (HP:0002883)	2.66628184
23	Abnormality of the renal medulla (HP:0100957)	2.60577510
24	Type II lissencephaly (HP:0007260)	2.60252947
25	Aplasia/Hypoplasia of the macula (HP:0008059)	2.59389043
26	Abolished electroretinogram (ERG) (HP:0000550)	2.58480943
27	Hypoglycemic coma (HP:0001325)	2.53685655
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.51020457
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.50370199
30	Methylmalonic acidemia (HP:0002912)	2.48095601
31	Gaze-evoked nystagmus (HP:0000640)	2.47855264
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.46148337
33	Occipital encephalocele (HP:0002085)	2.44213213
34	Pancreatic islet-cell hyperplasia (HP:0004510)	2.43828627
35	Central scotoma (HP:0000603)	2.42920316
36	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.37802396
37	Nephrogenic diabetes insipidus (HP:0009806)	2.37534128
38	Cystic liver disease (HP:0006706)	2.34011376
39	Degeneration of anterior horn cells (HP:0002398)	2.32124799
40	Abnormality of the anterior horn cell (HP:0006802)	2.32124799
41	Genital tract atresia (HP:0001827)	2.31644757
42	Progressive inability to walk (HP:0002505)	2.30648365
43	Pigmentary retinal degeneration (HP:0001146)	2.23809601
44	Disproportionate short-trunk short stature (HP:0003521)	2.21582977
45	Congenital sensorineural hearing impairment (HP:0008527)	2.20900327
46	Febrile seizures (HP:0002373)	2.19933929
47	Vaginal atresia (HP:0000148)	2.18542569
48	Methylmalonic aciduria (HP:0012120)	2.18126507
49	Attenuation of retinal blood vessels (HP:0007843)	2.17308235
50	Short tibia (HP:0005736)	2.15922021
51	Bifid tongue (HP:0010297)	2.12413932
52	Absent speech (HP:0001344)	2.10553501
53	Progressive macrocephaly (HP:0004481)	2.09336215
54	Astigmatism (HP:0000483)	2.07476777
55	Dyschromatopsia (HP:0007641)	2.07160071
56	Hemiparesis (HP:0001269)	2.06980961
57	Postaxial hand polydactyly (HP:0001162)	2.06146306
58	Hypothermia (HP:0002045)	2.05758067
59	Hyperinsulinemic hypoglycemia (HP:0000825)	2.04562291
60	Congenital hepatic fibrosis (HP:0002612)	2.02290435
61	Median cleft lip (HP:0000161)	2.01939806
62	Decreased central vision (HP:0007663)	2.01458759
63	Cerebellar dysplasia (HP:0007033)	1.99564773
64	Acute necrotizing encephalopathy (HP:0006965)	1.97791638
65	Oculomotor apraxia (HP:0000657)	1.97356961
66	Ketosis (HP:0001946)	1.96326831
67	Sclerocornea (HP:0000647)	1.96122455
68	Tubulointerstitial nephritis (HP:0001970)	1.95905150
69	Tubular atrophy (HP:0000092)	1.95868347
70	Epidermoid cyst (HP:0200040)	1.95838330
71	Abnormality of vitamin B metabolism (HP:0004340)	1.93657262
72	Abnormality of the labia minora (HP:0012880)	1.93096259
73	Postaxial foot polydactyly (HP:0001830)	1.92901992
74	Hyperglycinemia (HP:0002154)	1.92664295
75	Furrowed tongue (HP:0000221)	1.92284044
76	Acute encephalopathy (HP:0006846)	1.92003945
77	Ketoacidosis (HP:0001993)	1.90208325
78	Lissencephaly (HP:0001339)	1.89367913
79	Preaxial hand polydactyly (HP:0001177)	1.89205296
80	Type I transferrin isoform profile (HP:0003642)	1.88322588
81	Hypoplasia of the uterus (HP:0000013)	1.88230813
82	Inability to walk (HP:0002540)	1.87594131
83	Anencephaly (HP:0002323)	1.84655865
84	Small hand (HP:0200055)	1.83305856
85	Retinal dysplasia (HP:0007973)	1.81884113
86	Hypoglycemic seizures (HP:0002173)	1.77996457
87	Broad foot (HP:0001769)	1.76771431
88	Broad-based gait (HP:0002136)	1.76714485
89	Hepatic necrosis (HP:0002605)	1.76555637
90	Poor coordination (HP:0002370)	1.75809345
91	Narrow forehead (HP:0000341)	1.74971633
92	Male pseudohermaphroditism (HP:0000037)	1.73082326
93	Renal hypoplasia (HP:0000089)	1.72991538
94	Abnormal biliary tract physiology (HP:0012439)	1.72765291
95	Bile duct proliferation (HP:0001408)	1.72765291
96	Sloping forehead (HP:0000340)	1.71495869
97	Polydipsia (HP:0001959)	1.71315643
98	Abnormal drinking behavior (HP:0030082)	1.71315643
99	Scotoma (HP:0000575)	1.70348602
100	Abnormality of the metopic suture (HP:0005556)	1.70224084

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.41612206
2	MAP4K2	3.61871217
3	BMPR1B	3.18798806
4	INSRR	2.91929655
5	MAPK13	2.73339841
6	ACVR1B	2.56718739
7	CASK	2.38927472
8	PRKD3	2.30720986
9	TRIM28	2.22894334
10	TIE1	2.21300940
11	WNK3	2.20929015
12	GRK1	2.03450492
13	NUAK1	2.02932169
14	FER	1.81237065
15	IRAK1	1.79147474
16	PAK3	1.75961300
17	MKNK2	1.62710812
18	STK39	1.62494625
19	WEE1	1.55481012
20	PLK2	1.53828413
21	MST4	1.47477728
22	ADRBK2	1.45574853
23	MAP3K4	1.43067910
24	TNIK	1.42318440
25	PINK1	1.40793878
26	PDK2	1.40485693
27	MKNK1	1.40337206
28	BCR	1.38752152
29	ERBB3	1.36963371
30	BCKDK	1.20450664
31	CSNK1G1	1.16935858
32	PNCK	1.16774368
33	CSNK1G2	1.13339657
34	MAP2K7	1.11329072
35	EIF2AK3	1.11329006
36	CSNK1G3	1.10751188
37	MARK1	1.10327467
38	BRSK2	1.06435234
39	OXSR1	1.04121235
40	IRAK2	1.03483245
41	FGFR2	1.02753063
42	CSNK1A1L	1.00021340
43	PRKCE	0.99849598
44	NTRK3	0.97179470
45	PLK3	0.92875677
46	PLK4	0.90566536
47	EPHA4	0.87786788
48	PTK2B	0.87379233
49	FLT3	0.85978973
50	EIF2AK1	0.83246955
51	ZAK	0.81867524
52	MAP3K12	0.81101499
53	NEK1	0.80986549
54	AKT3	0.79417023
55	TGFBR1	0.77549474
56	DYRK2	0.75378465
57	CAMKK2	0.72631544
58	VRK1	0.72390956
59	PKN1	0.69280240
60	STK38L	0.66391557
61	ROCK1	0.65212717
62	PRKCG	0.64896869
63	SIK3	0.62814996
64	STK3	0.59778234
65	MAPKAPK5	0.59686924
66	EPHA3	0.59217761
67	DAPK2	0.58570366
68	WNK4	0.56420416
69	CCNB1	0.55721090
70	FGFR1	0.53276300
71	PLK1	0.53146163
72	YES1	0.52628510
73	PKN2	0.50980081
74	NTRK2	0.50330438
75	CDK8	0.48652811
76	ADRBK1	0.46931594
77	CAMK2A	0.44854994
78	PIK3CG	0.44486119
79	TAOK3	0.41623601
80	BRD4	0.39821564
81	PRKACA	0.36016401
82	RPS6KA4	0.35843588
83	ATR	0.35285924
84	DYRK3	0.34985068
85	PRKCI	0.34485746
86	PRKD2	0.34086937
87	ATM	0.33524543
88	TEC	0.33203496
89	CSNK1A1	0.32893590
90	VRK2	0.32681122
91	ROCK2	0.32402788
92	TTK	0.31775115
93	PRKG1	0.31093445
94	CAMK2D	0.30921196
95	ABL1	0.29550524
96	MINK1	0.29404946
97	MUSK	0.28551842
98	PRKACB	0.28047572
99	PRKCQ	0.26588546
100	CSNK1D	0.25904471

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.64112367
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.98941640
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.75375772
4	Propanoate metabolism_Homo sapiens_hsa00640	2.67401983
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.38815524
6	Butanoate metabolism_Homo sapiens_hsa00650	2.16817125
7	Proteasome_Homo sapiens_hsa03050	2.14444060
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.09743079
9	Phototransduction_Homo sapiens_hsa04744	2.06107099
10	Non-homologous end-joining_Homo sapiens_hsa03450	1.99749723
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89130672
12	Homologous recombination_Homo sapiens_hsa03440	1.86044812
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82028124
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77877868
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75550374
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.71576060
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.68112146
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.64527558
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.63672329
20	Basal transcription factors_Homo sapiens_hsa03022	1.63253497
21	Fatty acid elongation_Homo sapiens_hsa00062	1.60342342
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.46278292
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.38359033
24	Caffeine metabolism_Homo sapiens_hsa00232	1.37050920
25	Peroxisome_Homo sapiens_hsa04146	1.36854416
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36051906
27	Fatty acid metabolism_Homo sapiens_hsa01212	1.35336801
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.32829066
29	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.31430986
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25012182
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24330417
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.22722688
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22470988
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.21849420
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.17689870
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.14229065
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10341661
38	Regulation of autophagy_Homo sapiens_hsa04140	1.09284395
39	Sulfur metabolism_Homo sapiens_hsa00920	1.06523720
40	Nicotine addiction_Homo sapiens_hsa05033	1.05168817
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05108082
42	GABAergic synapse_Homo sapiens_hsa04727	1.04594231
43	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.03245374
44	Olfactory transduction_Homo sapiens_hsa04740	1.00447854
45	Sphingolipid metabolism_Homo sapiens_hsa00600	1.00323888
46	Glutathione metabolism_Homo sapiens_hsa00480	0.99898184
47	Morphine addiction_Homo sapiens_hsa05032	0.99544333
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99544292
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.98999381
50	RNA degradation_Homo sapiens_hsa03018	0.97099404
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95478586
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.92804588
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.91907629
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91047563
55	Insulin secretion_Homo sapiens_hsa04911	0.89159180
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.87878325
57	Mineral absorption_Homo sapiens_hsa04978	0.87731165
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87717469
59	Fatty acid degradation_Homo sapiens_hsa00071	0.86568766
60	Serotonergic synapse_Homo sapiens_hsa04726	0.84738619
61	RNA polymerase_Homo sapiens_hsa03020	0.83768303
62	Purine metabolism_Homo sapiens_hsa00230	0.82702523
63	Parkinsons disease_Homo sapiens_hsa05012	0.80689852
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.80574717
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80548827
66	Taste transduction_Homo sapiens_hsa04742	0.79210668
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78931920
68	Retinol metabolism_Homo sapiens_hsa00830	0.76051381
69	Circadian entrainment_Homo sapiens_hsa04713	0.75961099
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74529540
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.73543165
72	Metabolic pathways_Homo sapiens_hsa01100	0.69590465
73	Renin secretion_Homo sapiens_hsa04924	0.63871715
74	Arginine and proline metabolism_Homo sapiens_hsa00330	0.62437118
75	ABC transporters_Homo sapiens_hsa02010	0.60854948
76	One carbon pool by folate_Homo sapiens_hsa00670	0.59025251
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.58179254
78	Salivary secretion_Homo sapiens_hsa04970	0.54393294
79	Alzheimers disease_Homo sapiens_hsa05010	0.54248663
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.52708583
81	Circadian rhythm_Homo sapiens_hsa04710	0.52160731
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50811705
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.50729861
84	Oocyte meiosis_Homo sapiens_hsa04114	0.50061766
85	PPAR signaling pathway_Homo sapiens_hsa03320	0.48772907
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48728097
87	Huntingtons disease_Homo sapiens_hsa05016	0.48380015
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47008112
89	Folate biosynthesis_Homo sapiens_hsa00790	0.44508827
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44421982
91	Histidine metabolism_Homo sapiens_hsa00340	0.44262197
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.40624957
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.40294388
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39725531
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39246130
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38818172
97	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38461477
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37798820
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.36865687
100	RNA transport_Homo sapiens_hsa03013	0.36603743

ATP6V1G1P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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