ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	urate metabolic process (GO:0046415)	9.24156639
2	drug transmembrane transport (GO:0006855)	9.20223822
3	organic cation transport (GO:0015695)	8.33188387
4	drug transport (GO:0015893)	8.05603675
5	phosphate ion transport (GO:0006817)	7.31505274
6	lysine metabolic process (GO:0006553)	7.09582408
7	lysine catabolic process (GO:0006554)	7.09582408
8	excretion (GO:0007588)	6.83495327
9	quaternary ammonium group transport (GO:0015697)	6.28369807
10	glyoxylate metabolic process (GO:0046487)	6.08339677
11	phosphate ion transmembrane transport (GO:0035435)	5.97724100
12	response to mercury ion (GO:0046689)	5.73482653
13	renal absorption (GO:0070293)	5.66249308
14	cysteine metabolic process (GO:0006534)	5.65135942
15	metanephric nephron tubule development (GO:0072234)	5.51619968
16	metanephric tubule development (GO:0072170)	5.51619968
17	toxin transport (GO:1901998)	5.49779592
18	glycoside metabolic process (GO:0016137)	5.36959337
19	drug catabolic process (GO:0042737)	5.30348598
20	homocysteine metabolic process (GO:0050667)	5.24830755
21	vitamin D metabolic process (GO:0042359)	5.24646843
22	metanephric nephron epithelium development (GO:0072243)	5.17166803
23	trivalent inorganic anion homeostasis (GO:0072506)	5.08894255
24	phosphate ion homeostasis (GO:0055062)	5.08894255
25	exogenous drug catabolic process (GO:0042738)	5.08551560
26	tricarboxylic acid metabolic process (GO:0072350)	5.02551728
27	metanephric epithelium development (GO:0072207)	4.86601059
28	short-chain fatty acid metabolic process (GO:0046459)	4.76000734
29	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.74776429
30	nonribosomal peptide biosynthetic process (GO:0019184)	4.64251529
31	aspartate family amino acid catabolic process (GO:0009068)	4.36811357
32	polyol transport (GO:0015791)	4.36560575
33	nephron tubule development (GO:0072080)	4.32515998
34	tryptophan metabolic process (GO:0006568)	4.29447581
35	branched-chain amino acid metabolic process (GO:0009081)	4.28952776
36	amino-acid betaine transport (GO:0015838)	4.24205972
37	carnitine transport (GO:0015879)	4.24205972
38	indole-containing compound catabolic process (GO:0042436)	4.20256766
39	indolalkylamine catabolic process (GO:0046218)	4.20256766
40	tryptophan catabolic process (GO:0006569)	4.20256766
41	vitamin catabolic process (GO:0009111)	4.10849193
42	fat-soluble vitamin catabolic process (GO:0042363)	4.10849193
43	renal tubule development (GO:0061326)	4.08293434
44	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.02718179
45	aromatic amino acid family catabolic process (GO:0009074)	4.01020250
46	fatty acid beta-oxidation (GO:0006635)	3.92403139
47	modified amino acid transport (GO:0072337)	3.91626817
48	valine metabolic process (GO:0006573)	3.83110755
49	response to magnesium ion (GO:0032026)	3.78738582
50	glutathione biosynthetic process (GO:0006750)	3.76268320
51	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.74777318
52	L-phenylalanine metabolic process (GO:0006558)	3.74777318
53	carnitine metabolic process (GO:0009437)	3.66490592
54	L-phenylalanine catabolic process (GO:0006559)	3.63628000
55	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.63628000
56	amino-acid betaine metabolic process (GO:0006577)	3.61293576
57	indole-containing compound metabolic process (GO:0042430)	3.59918611
58	daunorubicin metabolic process (GO:0044597)	3.58906840
59	polyketide metabolic process (GO:0030638)	3.58906840
60	doxorubicin metabolic process (GO:0044598)	3.58906840
61	nephron epithelium development (GO:0072009)	3.57615493
62	peptide catabolic process (GO:0043171)	3.57568488
63	branched-chain amino acid catabolic process (GO:0009083)	3.53700868
64	serine family amino acid metabolic process (GO:0009069)	3.53476159
65	fatty acid oxidation (GO:0019395)	3.53225548
66	lipid oxidation (GO:0034440)	3.48842578
67	aldehyde catabolic process (GO:0046185)	3.48730140
68	indolalkylamine metabolic process (GO:0006586)	3.48496688
69	cellular response to vitamin D (GO:0071305)	3.47255764
70	serine family amino acid catabolic process (GO:0009071)	3.46997475
71	proline metabolic process (GO:0006560)	3.43862747
72	2-oxoglutarate metabolic process (GO:0006103)	3.39807907
73	NADH metabolic process (GO:0006734)	3.35867298
74	fructose metabolic process (GO:0006000)	3.35084505
75	peptide biosynthetic process (GO:0043043)	3.34958002
76	response to phenylpropanoid (GO:0080184)	3.32124204
77	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.29970990
78	nephron epithelium morphogenesis (GO:0072088)	3.27704958
79	nephron tubule morphogenesis (GO:0072078)	3.27704958
80	monocarboxylic acid catabolic process (GO:0072329)	3.25518771
81	polyol catabolic process (GO:0046174)	3.22107329
82	oligosaccharide catabolic process (GO:0009313)	3.21883977
83	cellular modified amino acid catabolic process (GO:0042219)	3.20841731
84	aromatic amino acid family metabolic process (GO:0009072)	3.17250112
85	fatty acid catabolic process (GO:0009062)	3.16689127
86	response to growth hormone (GO:0060416)	3.16552401
87	interferon-gamma production (GO:0032609)	3.16125822
88	sodium-independent organic anion transport (GO:0043252)	3.12814466
89	transepithelial transport (GO:0070633)	3.07693563
90	acetyl-CoA metabolic process (GO:0006084)	3.04929149
91	cellular ketone body metabolic process (GO:0046950)	3.04873620
92	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.03992485
93	glutathione metabolic process (GO:0006749)	3.02381268
94	sodium ion transport (GO:0006814)	2.99693839
95	sulfur compound transport (GO:0072348)	2.94176156
96	cytidine metabolic process (GO:0046087)	2.93741079
97	cytidine catabolic process (GO:0006216)	2.93741079
98	cytidine deamination (GO:0009972)	2.93741079
99	succinate metabolic process (GO:0006105)	2.91700946
100	aminoglycoside antibiotic metabolic process (GO:0030647)	12.2993845

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	3.01495389
2	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.71192658
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.62053056
4	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.54347254
5	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.53743683
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.50611233
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.42586157
8	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.27177968
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23219956
10	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.15769184
11	* SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.12396720
12	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.02648705
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.96895556
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.93763624
15	* PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.91248832
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87586915
17	* NFE2_27457419_Chip-Seq_LIVER_Mouse	1.86626073
18	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.84204486
19	* EZH2_27294783_Chip-Seq_NPCs_Mouse	1.75336556
20	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.72279110
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.70084884
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.70040347
23	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.65309120
24	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.64985453
25	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.62608146
26	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.62287148
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60488722
28	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.59531880
29	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.56514435
30	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.52962071
31	* VDR_22108803_ChIP-Seq_LS180_Human	1.51662735
32	* OCT4_18555785_Chip-Seq_ESCs_Mouse	1.45585596
33	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.44907938
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.41871363
35	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41014782
36	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.40515011
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.38683136
38	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.38334474
39	* KLF4_18555785_Chip-Seq_ESCs_Mouse	1.36881547
40	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.36020774
41	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.35882883
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35115167
43	* CRX_20693478_ChIP-Seq_RETINA_Mouse	1.33844318
44	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.30621709
45	* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30275764
46	* ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.28106564
47	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.27590420
48	* STAT3_18555785_Chip-Seq_ESCs_Mouse	1.27271556
49	TP53_18474530_ChIP-ChIP_U2OS_Human	1.27127862
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.26615118
51	* RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.25858401
52	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.24608256
53	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.24545169
54	* P53_22387025_ChIP-Seq_ESCs_Mouse	1.21790797
55	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.21773923
56	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.21222266
57	* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.21187966
58	* E2F1_18555785_Chip-Seq_ESCs_Mouse	1.21139928
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20873663
60	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.20824293
61	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.20824293
62	* ZFX_18555785_Chip-Seq_ESCs_Mouse	1.19720803
63	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.19604359
64	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.19297585
65	* P300_19829295_ChIP-Seq_ESCs_Human	1.19178989
66	* P300_18555785_Chip-Seq_ESCs_Mouse	1.18410691
67	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.17757262
68	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17325435
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.16559744
70	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.16531544
71	* ER_23166858_ChIP-Seq_MCF-7_Human	1.16313826
72	* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15343148
73	* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15282580
74	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.14780414
75	* SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.14363230
76	* CTCF_18555785_Chip-Seq_ESCs_Mouse	1.14220745
77	* SOX2_18555785_Chip-Seq_ESCs_Mouse	1.14174381
78	* NMYC_18555785_Chip-Seq_ESCs_Mouse	1.13648321
79	* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.13290681
80	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.13120094
81	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.13084404
82	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12168198
83	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.11899190
84	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11000966
85	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10330832
86	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.09936347
87	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09479882
88	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08601046
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.08199890
90	* NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06307670
91	STAT1_17558387_ChIP-Seq_HELA_Human	1.05894083
92	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05531806
93	GATA4_25053715_ChIP-Seq_YYC3_Human	1.05167888
94	* TCF4_22108803_ChIP-Seq_LS180_Human	1.04934804
95	* SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.04669324
96	* OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04579808
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03926251
98	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03567823
99	* VDR_24787735_ChIP-Seq_THP-1_Human	1.03563939
100	* PU1_27457419_Chip-Seq_LIVER_Mouse	1.02813769

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	6.54212457
2	MP0005360_urolithiasis	5.65758524
3	MP0004019_abnormal_vitamin_homeostasis	5.47318477
4	MP0003195_calcinosis	4.83582953
5	MP0005332_abnormal_amino_acid	4.32810320
6	MP0009643_abnormal_urine_homeostasis	3.94491892
7	MP0001765_abnormal_ion_homeostasis	3.86288959
8	MP0002138_abnormal_hepatobiliary_system	3.83797512
9	MP0002139_abnormal_hepatobiliary_system	3.47324619
10	MP0005451_abnormal_body_composition	3.39460521
11	MP0001756_abnormal_urination	3.16897727
12	MP0005636_abnormal_mineral_homeostasis	3.15245334
13	MP0002136_abnormal_kidney_physiology	3.09281110
14	MP0003878_abnormal_ear_physiology	2.62106435
15	MP0005377_hearing/vestibular/ear_phenot	2.62106435
16	MP0008875_abnormal_xenobiotic_pharmacok	2.11438534
17	MP0001958_emphysema	2.06853037
18	MP0005084_abnormal_gallbladder_morpholo	1.87559452
19	MP0003186_abnormal_redox_activity	1.87480873
20	MP0004885_abnormal_endolymph	1.85040356
21	MP0005365_abnormal_bile_salt	1.80654461
22	MP0003724_increased_susceptibility_to	1.80247822
23	MP0003252_abnormal_bile_duct	1.78912095
24	MP0005085_abnormal_gallbladder_physiolo	1.70740153
25	MP0004147_increased_porphyrin_level	1.65111940
26	MP0005220_abnormal_exocrine_pancreas	1.62037315
27	MP0008961_abnormal_basal_metabolism	1.59520078
28	MP0000538_abnormal_urinary_bladder	1.49140416
29	MP0001984_abnormal_olfaction	1.48975440
30	MP0002876_abnormal_thyroid_physiology	1.45951453
31	MP0010234_abnormal_vibrissa_follicle	1.45118457
32	MP0002168_other_aberrant_phenotype	1.29734393
33	MP0010386_abnormal_urinary_bladder	1.21237322
34	MP0005058_abnormal_lysosome_morphology	1.18736295
35	MP0002796_impaired_skin_barrier	1.16322118
36	MP0002135_abnormal_kidney_morphology	1.14086340
37	MP0005584_abnormal_enzyme/coenzyme_acti	1.13674536
38	MP0002928_abnormal_bile_duct	1.10894528
39	MP0009764_decreased_sensitivity_to	1.08602228
40	MP0000230_abnormal_systemic_arterial	1.07436848
41	MP0005501_abnormal_skin_physiology	1.01388374
42	MP0009379_abnormal_foot_pigmentation	1.01009324
43	MP0001188_hyperpigmentation	1.00736496
44	MP0009384_cardiac_valve_regurgitation	1.00220655
45	MP0005394_taste/olfaction_phenotype	0.98886564
46	MP0005499_abnormal_olfactory_system	0.98886564
47	MP0001666_abnormal_nutrient_absorption	0.97416162
48	MP0005408_hypopigmentation	0.96644534
49	MP0001764_abnormal_homeostasis	0.88337433
50	MP0006036_abnormal_mitochondrial_physio	0.86273313
51	MP0005535_abnormal_body_temperature	0.85295209
52	MP0005248_abnormal_Harderian_gland	0.84206842
53	MP0003868_abnormal_feces_composition	0.82671166
54	MP0005083_abnormal_biliary_tract	0.80569427
55	MP0004782_abnormal_surfactant_physiolog	0.80546036
56	MP0009672_abnormal_birth_weight	0.79641304
57	MP0002098_abnormal_vibrissa_morphology	0.79536616
58	MP0002896_abnormal_bone_mineralization	0.78814977
59	MP0005395_other_phenotype	0.75338664
60	MP0005319_abnormal_enzyme/_coenzyme	0.74890740
61	MP0003300_gastrointestinal_ulcer	0.74597693
62	MP0005646_abnormal_pituitary_gland	0.74496305
63	MP0003959_abnormal_lean_body	0.73406022
64	MP0003638_abnormal_response/metabolism_	0.72597092
65	MP0003866_abnormal_defecation	0.71667951
66	MP0000490_abnormal_crypts_of	0.63521418
67	MP0004742_abnormal_vestibular_system	0.63320743
68	MP0005666_abnormal_adipose_tissue	0.63189792
69	MP0008789_abnormal_olfactory_epithelium	0.61929193
70	MP0008469_abnormal_protein_level	0.61867075
71	MP0009642_abnormal_blood_homeostasis	0.61476270
72	MP0002115_abnormal_skeleton_extremities	0.61317711
73	MP0005670_abnormal_white_adipose	0.60263213
74	MP0003941_abnormal_skin_development	0.58602622
75	MP0000678_abnormal_parathyroid_gland	0.56982596
76	MP0002998_abnormal_bone_remodeling	0.56361064
77	MP0000371_diluted_coat_color	0.54779399
78	MP0002118_abnormal_lipid_homeostasis	0.50756234
79	MP0005165_increased_susceptibility_to	0.49137728
80	MP0003795_abnormal_bone_structure	0.46748301
81	MP0001790_abnormal_immune_system	0.45566257
82	MP0005387_immune_system_phenotype	0.45566257
83	MP0002089_abnormal_postnatal_growth/wei	0.44974276
84	MP0001485_abnormal_pinna_reflex	0.44548548
85	MP0000163_abnormal_cartilage_morphology	0.43598127
86	MP0005334_abnormal_fat_pad	0.43546299
87	MP0000026_abnormal_inner_ear	0.43525202
88	MP0005174_abnormal_tail_pigmentation	0.42262605
89	MP0002069_abnormal_eating/drinking_beha	0.41441102
90	MP0001191_abnormal_skin_condition	0.40678514
91	MP0001879_abnormal_lymphatic_vessel	0.40089201
92	MP0001177_atelectasis	0.38819114
93	MP0003879_abnormal_hair_cell	0.38403566
94	MP0001963_abnormal_hearing_physiology	0.38311156
95	MP0010155_abnormal_intestine_physiology	0.37999612
96	MP0001845_abnormal_inflammatory_respons	0.37823701
97	MP0000534_abnormal_ureter_morphology	0.37783746
98	MP0002396_abnormal_hematopoietic_system	0.36627637
99	MP0001664_abnormal_digestion	0.36153702
100	MP0000383_abnormal_hair_follicle	0.35150848

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Metabolic alkalosis (HP:0200114)	8.07113269
2	Increased circulating renin level (HP:0000848)	7.87645847
3	Hypokalemic alkalosis (HP:0001949)	7.84333979
4	Hypomagnesemia (HP:0002917)	7.42853362
5	Hyperactive renin-angiotensin system (HP:0000841)	7.29679504
6	Polyuria (HP:0000103)	7.14933049
7	Abnormal urine output (HP:0012590)	6.65345837
8	Abnormality of chloride homeostasis (HP:0011422)	6.53811538
9	Abnormality of magnesium homeostasis (HP:0004921)	6.37552375
10	Abnormality of renal excretion (HP:0011036)	6.22714812
11	Gout (HP:0001997)	6.15305624
12	Polydipsia (HP:0001959)	5.80922613
13	Abnormal drinking behavior (HP:0030082)	5.80922613
14	Tetany (HP:0001281)	5.48058815
15	Hyperaldosteronism (HP:0000859)	5.39360874
16	Proximal tubulopathy (HP:0000114)	5.35510819
17	Abnormality of renin-angiotensin system (HP:0000847)	5.26448593
18	Renal salt wasting (HP:0000127)	5.08182832
19	Alkalosis (HP:0001948)	5.06906815
20	Increased purine levels (HP:0004368)	4.49752154
21	Hyperuricemia (HP:0002149)	4.49752154
22	Generalized aminoaciduria (HP:0002909)	4.29740917
23	Hypokalemia (HP:0002900)	4.16659612
24	Hyperglycinuria (HP:0003108)	4.03696551
25	Hypercalciuria (HP:0002150)	3.79775014
26	Renal tubular acidosis (HP:0001947)	3.76075420
27	Abnormality of purine metabolism (HP:0004352)	3.74909045
28	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.52328936
29	Abnormality of potassium homeostasis (HP:0011042)	3.35694994
30	Dehydration (HP:0001944)	3.24842362
31	Abnormality of urine glucose concentration (HP:0011016)	3.18972378
32	Glycosuria (HP:0003076)	3.18972378
33	Abnormality of serine family amino acid metabolism (HP:0010894)	3.04937075
34	Abnormality of glycine metabolism (HP:0010895)	3.04937075
35	Ketoacidosis (HP:0001993)	3.01141425
36	Hyperphosphaturia (HP:0003109)	2.87607907
37	Nephrocalcinosis (HP:0000121)	2.82355919
38	Abnormal urine phosphate concentration (HP:0012599)	2.78890002
39	Abnormality of nucleobase metabolism (HP:0010932)	2.75172089
40	Abnormality of fatty-acid metabolism (HP:0004359)	2.74249796
41	Abnormality of sodium homeostasis (HP:0010931)	2.71581287
42	Hyponatremia (HP:0002902)	2.68939158
43	Delayed epiphyseal ossification (HP:0002663)	2.56856093
44	Enlarged kidneys (HP:0000105)	2.52586072
45	Widely patent fontanelles and sutures (HP:0004492)	2.51498011
46	Nephrolithiasis (HP:0000787)	2.48465781
47	Decreased circulating renin level (HP:0003351)	2.43909006
48	Ketosis (HP:0001946)	2.41380452
49	Tubulointerstitial fibrosis (HP:0005576)	2.38183384
50	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.37848229
51	Rickets (HP:0002748)	2.37037827
52	Hypophosphatemia (HP:0002148)	2.36885697
53	Tubular atrophy (HP:0000092)	2.35818175
54	Renal tubular dysfunction (HP:0000124)	2.35343641
55	Adrenal overactivity (HP:0002717)	2.31935405
56	Abnormality of renal resorption (HP:0011038)	2.26804379
57	Abnormality of the renal cortex (HP:0011035)	2.24739540
58	Vacuolated lymphocytes (HP:0001922)	2.23705839
59	Vomiting (HP:0002013)	2.22850683
60	Hyperglycinemia (HP:0002154)	2.16554057
61	Abnormality of proline metabolism (HP:0010907)	2.12014572
62	Hydroxyprolinuria (HP:0003080)	2.12014572
63	Bilateral sensorineural hearing impairment (HP:0008619)	2.11130816
64	Dicarboxylic aciduria (HP:0003215)	2.10230972
65	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.10230972
66	Neonatal onset (HP:0003623)	2.09864038
67	Vascular calcification (HP:0004934)	2.05430066
68	Metabolic acidosis (HP:0001942)	2.00999246
69	Renal cortical cysts (HP:0000803)	1.97554980
70	Facial shape deformation (HP:0011334)	1.84954799
71	Potter facies (HP:0002009)	1.84954799
72	Hyperammonemia (HP:0001987)	1.77098332
73	Abnormality of Sharpey fibers (HP:0100685)	1.75604675
74	Cardiovascular calcification (HP:0011915)	1.75574643
75	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.75378369
76	Hypophosphatemic rickets (HP:0004912)	1.73967118
77	Metaphyseal cupping (HP:0003021)	1.72454645
78	Chondrocalcinosis (HP:0000934)	1.72210341
79	Delayed CNS myelination (HP:0002188)	1.71251883
80	Hypothermia (HP:0002045)	1.71140999
81	Tubulointerstitial abnormality (HP:0001969)	1.70606982
82	Metaphyseal irregularity (HP:0003025)	1.67831774
83	Bicornuate uterus (HP:0000813)	1.67770827
84	Thin bony cortex (HP:0002753)	1.67397355
85	Metaphyseal dysplasia (HP:0100255)	1.63041487
86	Lethargy (HP:0001254)	1.62715882
87	Hypotension (HP:0002615)	1.62646836
88	Methylmalonic aciduria (HP:0012120)	1.60860823
89	Generalized muscle weakness (HP:0003324)	1.59067364
90	Tachypnea (HP:0002789)	1.54677403
91	Malnutrition (HP:0004395)	1.54264017
92	Enlarged epiphyses (HP:0010580)	1.53522870
93	Confusion (HP:0001289)	1.53471584
94	Nausea (HP:0002018)	1.52152871
95	Abnormal enzyme/coenzyme activity (HP:0012379)	1.51904687
96	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.50685534
97	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.50685534
98	Glomerulosclerosis (HP:0000096)	1.48897267
99	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.48808201
100	Abnormality of the costochondral junction (HP:0000919)	1.47905801

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	7.80101286
2	WNK3	7.66189134
3	OXSR1	7.05803658
4	STK39	3.66628875
5	SGK223	2.23262588
6	SGK494	2.23262588
7	TXK	1.99052687
8	SRPK1	1.98523841
9	STK38L	1.96274164
10	SGK2	1.92229280
11	MAP2K6	1.64927346
12	BCKDK	1.62038712
13	SGK3	1.48752630
14	SIK3	1.34910053
15	DAPK2	1.32020594
16	IRAK3	1.27794776
17	MAP3K14	1.26015262
18	WNK1	1.25500218
19	MST4	1.18023197
20	MYLK	1.13275324
21	GRK1	1.12892546
22	NEK6	1.12483141
23	PDK2	1.06141757
24	MAP3K12	1.01169560
25	MST1R	0.95098311
26	PDK3	0.87935565
27	PDK4	0.87935565
28	STK11	0.86299121
29	PAK4	0.84575150
30	PIK3CA	0.82642739
31	ACVR1B	0.81298445
32	IRAK2	0.74608697
33	PINK1	0.71112998
34	CASK	0.69461369
35	EIF2AK2	0.67839351
36	STK38	0.66945727
37	MAP3K7	0.62645296
38	BMPR2	0.60656644
39	RIPK4	0.60352345
40	GSK3A	0.58525380
41	ADRBK2	0.58524997
42	BCR	0.58508726
43	SIK1	0.58507094
44	ZAK	0.58384682
45	PRKCI	0.57971407
46	SGK1	0.56741886
47	IRAK1	0.56703044
48	INSRR	0.55285516
49	MAP3K2	0.53743123
50	FGFR4	0.52236395
51	TRPM7	0.46365757
52	ERBB4	0.45130247
53	NEK9	0.44124665
54	YES1	0.43589026
55	EPHA4	0.42869616
56	PRKCZ	0.41172891
57	IRAK4	0.40717294
58	PRKCD	0.39785175
59	MAP4K1	0.37235855
60	CAMKK2	0.36794365
61	NEK1	0.36223227
62	ERBB3	0.34278312
63	PIK3CG	0.33910777
64	CAMK4	0.33311235
65	MAP2K3	0.32511467
66	PRKCG	0.31516790
67	TLK1	0.29869322
68	DYRK1B	0.29340924
69	CAMK1	0.29232820
70	IKBKE	0.28310790
71	PKN1	0.27105366
72	PTK2	0.26889036
73	NTRK3	0.26751726
74	MAPK11	0.26656444
75	MAP2K7	0.26467129
76	PTK6	0.25961000
77	PRKACA	0.25818345
78	OBSCN	0.25785726
79	MAP3K3	0.25765615
80	PAK3	0.24577787
81	PRKCA	0.23152236
82	CSNK1A1	0.22860278
83	PRKCQ	0.22591193
84	NME1	0.22349109
85	PRKCE	0.21448121
86	TNK2	0.19570239
87	TIE1	0.19474897
88	PRKAA1	0.18861401
89	PRPF4B	0.18798931
90	MAPK12	0.18784073
91	ABL2	0.17589369
92	LYN	0.16603420
93	CHUK	0.16450079
94	TYK2	0.15819970
95	FRK	0.15562639
96	GRK6	0.14934417
97	PRKACG	0.14684165
98	MAPK4	0.13932354
99	FER	0.12312108
100	EIF2AK1	0.12119706

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.89014755
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.62819941
3	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.30805831
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.22898931
5	Propanoate metabolism_Homo sapiens_hsa00640	3.17518816
6	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.11500726
7	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.00509839
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.86295726
9	Peroxisome_Homo sapiens_hsa04146	2.82242003
10	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.77648812
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.56002192
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.51303612
13	* Collecting duct acid secretion_Homo sapiens_hsa04966	2.47765289
14	Fatty acid degradation_Homo sapiens_hsa00071	2.41762818
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.28963586
16	beta-Alanine metabolism_Homo sapiens_hsa00410	2.15033348
17	Tryptophan metabolism_Homo sapiens_hsa00380	2.13151303
18	Pyruvate metabolism_Homo sapiens_hsa00620	2.07065839
19	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.02863970
20	Sulfur metabolism_Homo sapiens_hsa00920	1.81681833
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.73792343
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.66623596
23	Glutathione metabolism_Homo sapiens_hsa00480	1.64313592
24	Phenylalanine metabolism_Homo sapiens_hsa00360	1.60258286
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.52122371
26	Carbon metabolism_Homo sapiens_hsa01200	1.48691296
27	Mineral absorption_Homo sapiens_hsa04978	1.48163869
28	Fatty acid elongation_Homo sapiens_hsa00062	1.43536976
29	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.38442595
30	Other glycan degradation_Homo sapiens_hsa00511	1.37532129
31	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.37224168
32	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.30946358
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.28265780
34	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.26754045
35	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.25504525
36	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.22936172
37	Arginine and proline metabolism_Homo sapiens_hsa00330	1.22387171
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.22170430
39	Bile secretion_Homo sapiens_hsa04976	1.20233974
40	Protein digestion and absorption_Homo sapiens_hsa04974	1.19722560
41	PPAR signaling pathway_Homo sapiens_hsa03320	1.05298512
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04972520
43	* Oxidative phosphorylation_Homo sapiens_hsa00190	0.99421629
44	Histidine metabolism_Homo sapiens_hsa00340	0.98405607
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.96021484
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93116159
47	Folate biosynthesis_Homo sapiens_hsa00790	0.91060237
48	Lysine degradation_Homo sapiens_hsa00310	0.87415706
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.82195164
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82054867
51	Renin-angiotensin system_Homo sapiens_hsa04614	0.76533893
52	Retinol metabolism_Homo sapiens_hsa00830	0.74999958
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74261669
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73234191
55	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.66207789
56	Pentose phosphate pathway_Homo sapiens_hsa00030	0.66089563
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65198984
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64318944
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59336425
60	Parkinsons disease_Homo sapiens_hsa05012	0.59188147
61	* Metabolic pathways_Homo sapiens_hsa01100	0.58570422
62	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.58166106
63	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.53851194
64	Graft-versus-host disease_Homo sapiens_hsa05332	0.51199708
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.50589825
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.49718200
67	Lysosome_Homo sapiens_hsa04142	0.46741110
68	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46712346
69	ABC transporters_Homo sapiens_hsa02010	0.42825061
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42728035
71	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.42628198
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.40361351
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37738271
74	Gastric acid secretion_Homo sapiens_hsa04971	0.34569792
75	* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.34354635
76	* Rheumatoid arthritis_Homo sapiens_hsa05323	0.34348780
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.29897800
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26736120
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25486785
80	* Vibrio cholerae infection_Homo sapiens_hsa05110	0.23303687
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.20678775
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.20502352
83	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.20390145
84	Alzheimers disease_Homo sapiens_hsa05010	0.19713724
85	Galactose metabolism_Homo sapiens_hsa00052	0.19025280
86	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.18391403
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.18350013
88	Arginine biosynthesis_Homo sapiens_hsa00220	0.17396156
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.15834704
90	Hepatitis C_Homo sapiens_hsa05160	0.15229756
91	Cardiac muscle contraction_Homo sapiens_hsa04260	0.14982429
92	One carbon pool by folate_Homo sapiens_hsa00670	0.13790497
93	Sulfur relay system_Homo sapiens_hsa04122	0.12040927
94	* Synaptic vesicle cycle_Homo sapiens_hsa04721	0.09853017
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.08713522
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.06285807
97	Huntingtons disease_Homo sapiens_hsa05016	0.04214618
98	Mismatch repair_Homo sapiens_hsa03430	0.03989339
99	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.03218234
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.01743442

ATP6V1G3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »