ATP6V1H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.39922174
2neuron cell-cell adhesion (GO:0007158)4.93716140
3regulation of synaptic vesicle exocytosis (GO:2000300)4.86195082
4glutamate secretion (GO:0014047)4.75943118
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66813014
6vocalization behavior (GO:0071625)4.43924516
7negative regulation of synaptic transmission, GABAergic (GO:0032229)4.37003200
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.30885956
9* ATP hydrolysis coupled proton transport (GO:0015991)4.29066276
10* energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.29066276
11* transferrin transport (GO:0033572)4.27754223
12regulation of synaptic vesicle transport (GO:1902803)4.26583420
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.25531172
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.25422212
15presynaptic membrane assembly (GO:0097105)4.12837435
16protein localization to synapse (GO:0035418)4.09701293
17neuronal action potential propagation (GO:0019227)4.08196967
18synaptic vesicle maturation (GO:0016188)4.03276005
19* trivalent inorganic cation transport (GO:0072512)3.99713268
20* ferric iron transport (GO:0015682)3.99713268
21neurotransmitter secretion (GO:0007269)3.97962235
22regulation of glutamate receptor signaling pathway (GO:1900449)3.97783830
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94737652
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94168649
25presynaptic membrane organization (GO:0097090)3.81047381
26gamma-aminobutyric acid signaling pathway (GO:0007214)3.75837407
27neuron-neuron synaptic transmission (GO:0007270)3.71017396
28neurotransmitter-gated ion channel clustering (GO:0072578)3.67059880
29negative regulation of dendrite morphogenesis (GO:0050774)3.65946868
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.64316633
31cellular potassium ion homeostasis (GO:0030007)3.62786543
32long-term synaptic potentiation (GO:0060291)3.58699418
33neurofilament cytoskeleton organization (GO:0060052)3.56516516
34glutamate receptor signaling pathway (GO:0007215)3.51385800
35negative regulation of amino acid transport (GO:0051956)3.48105983
36synaptic transmission, glutamatergic (GO:0035249)3.45739596
37* phagosome maturation (GO:0090382)3.44679499
38neuromuscular process controlling posture (GO:0050884)3.44295144
39ganglioside metabolic process (GO:0001573)3.42016174
40neuron recognition (GO:0008038)3.41471927
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33277984
42neurotransmitter transport (GO:0006836)3.33017039
43proline transport (GO:0015824)3.32144179
44regulation of vesicle fusion (GO:0031338)3.32071552
45acidic amino acid transport (GO:0015800)3.31410197
46postsynaptic membrane organization (GO:0001941)3.30498740
47glycosphingolipid catabolic process (GO:0046479)3.30496412
48gamma-aminobutyric acid transport (GO:0015812)3.28417003
49regulation of neuronal synaptic plasticity (GO:0048168)3.24571774
50locomotory exploration behavior (GO:0035641)3.23899818
51regulation of neurotransmitter secretion (GO:0046928)3.18188484
52oligosaccharide catabolic process (GO:0009313)3.16757853
53regulation of glutamate secretion (GO:0014048)3.15673101
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10966287
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10128911
56negative regulation of dendrite development (GO:2000171)3.08932722
57startle response (GO:0001964)3.08340059
58pyrimidine nucleobase catabolic process (GO:0006208)3.07586651
59regulation of neurotransmitter levels (GO:0001505)3.07130905
60L-glutamate transport (GO:0015813)3.06912801
61synaptic vesicle endocytosis (GO:0048488)3.06811596
62establishment of synaptic vesicle localization (GO:0097480)3.06312005
63synaptic vesicle transport (GO:0048489)3.06312005
64exploration behavior (GO:0035640)3.05081548
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.05021062
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03000649
67regulation of synaptic plasticity (GO:0048167)3.02063011
68regulation of mononuclear cell migration (GO:0071675)3.01788349
69transmission of nerve impulse (GO:0019226)3.01402034
70detection of calcium ion (GO:0005513)3.00319661
71regulation of postsynaptic membrane potential (GO:0060078)2.99692617
72glycolipid catabolic process (GO:0019377)2.98725510
73regulation of neurotransmitter transport (GO:0051588)2.97862971
74response to histamine (GO:0034776)2.97142810
75establishment of melanosome localization (GO:0032401)2.96847317
76regulation of synapse structural plasticity (GO:0051823)2.96612314
77negative regulation of neurotransmitter transport (GO:0051589)2.96240054
78axonal fasciculation (GO:0007413)2.95500877
79positive regulation of membrane potential (GO:0045838)2.94760411
80sodium ion export (GO:0071436)2.94473747
81establishment of pigment granule localization (GO:0051905)2.94296850
82melanosome transport (GO:0032402)2.92391530
83positive regulation of neurotransmitter transport (GO:0051590)2.92364717
84L-amino acid import (GO:0043092)2.92252206
85amino acid import (GO:0043090)2.91311513
86establishment of vesicle localization (GO:0051650)2.90053476
87pigment granule transport (GO:0051904)2.89927668
88synapse assembly (GO:0007416)2.89640669
89amino sugar catabolic process (GO:0046348)2.85754636
90behavioral response to cocaine (GO:0048148)2.84768463
91positive regulation of synapse assembly (GO:0051965)2.84496800
92adult walking behavior (GO:0007628)2.83356249
93ceramide catabolic process (GO:0046514)2.82961954
94cerebellar Purkinje cell differentiation (GO:0021702)2.82384828
95synaptic transmission (GO:0007268)2.81384136
96vesicle transport along microtubule (GO:0047496)2.80637061
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80614476
98positive regulation of synaptic transmission (GO:0050806)2.80500033
99regulation of synaptic transmission, GABAergic (GO:0032228)2.79943360
100positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79422088
101* iron ion transport (GO:0006826)2.77279307
102female mating behavior (GO:0060180)2.76641906
103calcium ion-dependent exocytosis (GO:0017156)2.75583460
104positive regulation of neurotransmitter secretion (GO:0001956)2.74696909
105layer formation in cerebral cortex (GO:0021819)2.73933670
106* cellular iron ion homeostasis (GO:0006879)2.72094696
107cerebellar granule cell differentiation (GO:0021707)2.71242825
108protein localization to cilium (GO:0061512)2.70994893
109mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.70063775
110regulation of synaptic transmission (GO:0050804)2.69057837
111eosinophil chemotaxis (GO:0048245)2.68809342
112dendrite development (GO:0016358)2.68689266
113neuronal ion channel clustering (GO:0045161)2.68566757
114striatum development (GO:0021756)2.68155671
115negative regulation of microtubule polymerization (GO:0031115)2.68102069
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67701107
117regulation of female receptivity (GO:0045924)2.67452065
118regulation of vitamin D biosynthetic process (GO:0060556)2.65534843
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.65518837
120positive regulation of vesicle fusion (GO:0031340)2.65392088
121establishment of mitochondrion localization (GO:0051654)2.64080348
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63337224
123regulation of exocytosis (GO:0017157)2.63207045
124mechanosensory behavior (GO:0007638)2.62997430
125membrane depolarization (GO:0051899)2.62910555
126response to auditory stimulus (GO:0010996)2.62356030
127chaperone-mediated protein transport (GO:0072321)2.62140677
128long-term memory (GO:0007616)2.62132777
129G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62068467
130activation of protein kinase A activity (GO:0034199)2.61865958
131melanosome localization (GO:0032400)2.59881536
132vesicle docking involved in exocytosis (GO:0006904)2.59579451
133nucleobase catabolic process (GO:0046113)2.59297905
134pigment granule localization (GO:0051875)2.59013737
135response to dietary excess (GO:0002021)2.58903109
136glycerophospholipid catabolic process (GO:0046475)2.57186672
137righting reflex (GO:0060013)2.55213555
138protein localization to endosome (GO:0036010)2.55203558
139positive regulation of heat generation (GO:0031652)2.54149911
140positive regulation of dendritic spine development (GO:0060999)2.52025630
141cellular response to thyroid hormone stimulus (GO:0097067)2.51907685
142membrane lipid catabolic process (GO:0046466)2.50841916
143vesicle docking (GO:0048278)2.48648001
144response to acidic pH (GO:0010447)2.48448605
145neuromuscular process controlling balance (GO:0050885)2.46828259
146regulation of fever generation (GO:0031620)2.43774343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.80960971
2GBX2_23144817_ChIP-Seq_PC3_Human4.64438511
3TAF15_26573619_Chip-Seq_HEK293_Human3.05869903
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92091921
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69127308
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.57141632
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50090101
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49377026
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43212943
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40869760
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36408264
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36402791
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30650136
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27322345
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.25445066
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21071476
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17697887
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15118266
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14433476
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14048547
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13683842
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12508463
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12508463
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.11487651
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.11200774
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09877072
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07044282
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.05538585
29P300_19829295_ChIP-Seq_ESCs_Human2.02698505
30SMAD4_21799915_ChIP-Seq_A2780_Human1.97564568
31VDR_22108803_ChIP-Seq_LS180_Human1.96039173
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91100166
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.86891931
34IGF1R_20145208_ChIP-Seq_DFB_Human1.81354210
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77504119
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77463666
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75859159
38* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73450312
39AR_21572438_ChIP-Seq_LNCaP_Human1.73432995
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73045081
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72945125
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.71093616
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68604032
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.67061758
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.62784261
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61770150
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.61008551
48FUS_26573619_Chip-Seq_HEK293_Human1.60114319
49ER_23166858_ChIP-Seq_MCF-7_Human1.57976695
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.57333082
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.55703318
52AR_25329375_ChIP-Seq_VCAP_Human1.54140259
53DROSHA_22980978_ChIP-Seq_HELA_Human1.53391755
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51928571
55REST_19997604_ChIP-ChIP_NEURONS_Mouse1.45324217
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.40164628
57RNF2_27304074_Chip-Seq_NSC_Mouse1.37338300
58* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36830345
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36528961
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33332935
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.33230006
62JUN_21703547_ChIP-Seq_K562_Human1.31886362
63STAT3_23295773_ChIP-Seq_U87_Human1.31119753
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28876773
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.28709791
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26150560
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24896657
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24047057
69* NANOG_18555785_Chip-Seq_ESCs_Mouse1.23511243
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23069857
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.21676834
72RUNX2_22187159_ChIP-Seq_PCA_Human1.20578739
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.20292418
74* TFEB_21752829_ChIP-Seq_HELA_Human1.19889281
75* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19039133
76* TCF4_23295773_ChIP-Seq_U87_Human1.18714209
77* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18227345
78ZNF274_21170338_ChIP-Seq_K562_Hela1.17983694
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17434648
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17285362
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14252407
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14252407
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13397243
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13305108
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12072970
86TP53_18474530_ChIP-ChIP_U2OS_Human1.11433683
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10512610
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08924080
89* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08699178
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08176864
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07896701
92* P53_22387025_ChIP-Seq_ESCs_Mouse1.07419086
93* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07040474
94* SOX2_18555785_Chip-Seq_ESCs_Mouse1.06520105
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06120391
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05917322
97KDM2B_26808549_Chip-Seq_REH_Human1.05515210
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05126026
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.04897722
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04597525
101BCAT_22108803_ChIP-Seq_LS180_Human1.03833910
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03139051
103* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02984242
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02565577
105* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02386653
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.00956656
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.00457327
108* PU1_27457419_Chip-Seq_LIVER_Mouse1.00119995
109* FLI1_27457419_Chip-Seq_LIVER_Mouse0.99668282
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99431825
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99409431
112CBP_20019798_ChIP-Seq_JUKART_Human0.99409431
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98938573
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98740105
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98729254
116* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97845600
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.97833907
118AHR_22903824_ChIP-Seq_MCF-7_Human0.96740143
119EGR1_19032775_ChIP-ChIP_M12_Human0.96317441
120HTT_18923047_ChIP-ChIP_STHdh_Human0.96229401
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94848745
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94275459
123* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94260918
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94124542
125* STAT3_18555785_Chip-Seq_ESCs_Mouse0.94062110
126* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93670018
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93598960
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92653660
129* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92336127
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91574171
131KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91368469
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88173794
133* NMYC_18555785_Chip-Seq_ESCs_Mouse0.86956560
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.86305124
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86162085
136* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.85911967
137* P300_18555785_Chip-Seq_ESCs_Mouse0.84686198
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84441079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.08730502
2MP0004859_abnormal_synaptic_plasticity4.77578036
3MP0003635_abnormal_synaptic_transmissio3.63291240
4MP0004270_analgesia3.43811316
5MP0005058_abnormal_lysosome_morphology3.27548454
6MP0009745_abnormal_behavioral_response3.25665675
7MP0001968_abnormal_touch/_nociception3.20061014
8MP0002064_seizures3.16928109
9MP0009046_muscle_twitch3.10497595
10MP0002063_abnormal_learning/memory/cond3.04252345
11MP0002736_abnormal_nociception_after2.92552126
12MP0002734_abnormal_mechanical_nocicepti2.81343438
13MP0002735_abnormal_chemical_nociception2.75386344
14MP0002572_abnormal_emotion/affect_behav2.69570464
15MP0006276_abnormal_autonomic_nervous2.65131095
16MP0002272_abnormal_nervous_system2.57518617
17MP0001501_abnormal_sleep_pattern2.46791129
18MP0002822_catalepsy2.35572906
19MP0009840_abnormal_foam_cell2.35454044
20MP0001440_abnormal_grooming_behavior2.28686969
21MP0001529_abnormal_vocalization2.25336548
22MP0001486_abnormal_startle_reflex2.23016551
23MP0002733_abnormal_thermal_nociception2.17511518
24MP0001970_abnormal_pain_threshold2.11540089
25MP0009780_abnormal_chondrocyte_physiolo2.06838386
26MP0002067_abnormal_sensory_capabilities2.03320072
27MP0010386_abnormal_urinary_bladder1.99509742
28MP0005167_abnormal_blood-brain_barrier1.98276903
29MP0005646_abnormal_pituitary_gland1.93820851
30MP0001984_abnormal_olfaction1.90454513
31MP0001905_abnormal_dopamine_level1.81438119
32MP0003191_abnormal_cellular_cholesterol1.80322618
33MP0004924_abnormal_behavior1.78911449
34MP0005386_behavior/neurological_phenoty1.78911449
35MP0002876_abnormal_thyroid_physiology1.78736951
36MP0000343_altered_response_to1.77554539
37MP0000778_abnormal_nervous_system1.76402128
38MP0002184_abnormal_innervation1.76109586
39MP0001188_hyperpigmentation1.74445277
40MP0003329_amyloid_beta_deposits1.74438726
41MP0004858_abnormal_nervous_system1.70195052
42MP0005645_abnormal_hypothalamus_physiol1.66069468
43MP0005423_abnormal_somatic_nervous1.62948892
44MP0003303_peritoneal_inflammation1.62356320
45MP0006082_CNS_inflammation1.60944897
46MP0003879_abnormal_hair_cell1.59764656
47MP0002557_abnormal_social/conspecific_i1.59630969
48MP0002909_abnormal_adrenal_gland1.59517035
49MP0003183_abnormal_peptide_metabolism1.55522008
50MP0004811_abnormal_neuron_physiology1.54750995
51MP0003075_altered_response_to1.52975372
52MP0003787_abnormal_imprinting1.47931045
53MP0004510_myositis1.46475923
54MP0004142_abnormal_muscle_tone1.44859908
55MP0005171_absent_coat_pigmentation1.43130757
56MP0003806_abnormal_nucleotide_metabolis1.38748595
57MP0002837_dystrophic_cardiac_calcinosis1.35000567
58MP0000955_abnormal_spinal_cord1.34138563
59MP0003122_maternal_imprinting1.33821357
60MP0002066_abnormal_motor_capabilities/c1.33038782
61MP0000013_abnormal_adipose_tissue1.28723746
62MP0008569_lethality_at_weaning1.28406361
63MP0002148_abnormal_hypersensitivity_rea1.28127067
64MP0002882_abnormal_neuron_morphology1.27681340
65MP0002139_abnormal_hepatobiliary_system1.21733277
66MP0003633_abnormal_nervous_system1.18643644
67MP0001502_abnormal_circadian_rhythm1.17790588
68MP0001986_abnormal_taste_sensitivity1.17054281
69MP0004043_abnormal_pH_regulation1.13182806
70MP0002102_abnormal_ear_morphology1.10896217
71MP0000604_amyloidosis1.09121528
72MP0003631_nervous_system_phenotype1.07552653
73MP0009764_decreased_sensitivity_to1.06892608
74MP0004742_abnormal_vestibular_system1.05577518
75MP0005535_abnormal_body_temperature1.04808185
76MP0002332_abnormal_exercise_endurance1.02931579
77MP0002229_neurodegeneration1.01921955
78MP0009785_altered_susceptibility_to1.00738000
79MP0004885_abnormal_endolymph1.00348782
80MP0002638_abnormal_pupillary_reflex0.99005448
81MP0002069_abnormal_eating/drinking_beha0.96283824
82MP0005253_abnormal_eye_physiology0.93906174
83MP0005551_abnormal_eye_electrophysiolog0.92900762
84MP0008872_abnormal_physiological_respon0.92252723
85MP0004147_increased_porphyrin_level0.92197929
86MP0003634_abnormal_glial_cell0.91763505
87MP0003195_calcinosis0.91652354
88MP0001963_abnormal_hearing_physiology0.91536055
89MP0003186_abnormal_redox_activity0.90195620
90MP0005499_abnormal_olfactory_system0.87752405
91MP0005394_taste/olfaction_phenotype0.87752405
92MP0001664_abnormal_digestion0.86663148
93MP0003123_paternal_imprinting0.86464772
94MP0003300_gastrointestinal_ulcer0.85273590
95MP0002152_abnormal_brain_morphology0.84661171
96MP0002090_abnormal_vision0.84378210
97MP0000372_irregular_coat_pigmentation0.84356952
98MP0001177_atelectasis0.82988648
99MP0003172_abnormal_lysosome_physiology0.80777765
100MP0003632_abnormal_nervous_system0.80710297
101MP0008260_abnormal_autophagy0.80227048
102MP0000920_abnormal_myelination0.77940852
103MP0000371_diluted_coat_color0.75667590
104MP0005379_endocrine/exocrine_gland_phen0.75328593
105MP0001542_abnormal_bone_strength0.74702115
106MP0003656_abnormal_erythrocyte_physiolo0.73174102
107MP0000681_abnormal_thyroid_gland0.72115652
108MP0000631_abnormal_neuroendocrine_gland0.70842408
109MP0000538_abnormal_urinary_bladder0.69368919
110MP0002751_abnormal_autonomic_nervous0.68440946
111MP0003137_abnormal_impulse_conducting0.68411319
112MP0003121_genomic_imprinting0.67910227
113MP0002752_abnormal_somatic_nervous0.67362386
114MP0005248_abnormal_Harderian_gland0.67102614
115MP0008874_decreased_physiological_sensi0.66435163
116MP0003690_abnormal_glial_cell0.66223741
117MP0006072_abnormal_retinal_apoptosis0.65901637
118MP0000015_abnormal_ear_pigmentation0.64065391
119MP0005310_abnormal_salivary_gland0.63198622
120MP0000569_abnormal_digit_pigmentation0.61465420
121MP0004085_abnormal_heartbeat0.60900740
122MP0004484_altered_response_of0.56955860
123MP0006035_abnormal_mitochondrial_morpho0.56022310
124MP0008004_abnormal_stomach_pH0.53620242
125MP0005409_darkened_coat_color0.51853678
126MP0009697_abnormal_copulation0.50832915
127MP0002163_abnormal_gland_morphology0.50657483
128MP0001485_abnormal_pinna_reflex0.50143600
129MP0000026_abnormal_inner_ear0.49610576

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.78232611
2Abnormality of glycolipid metabolism (HP:0010969)6.18017045
3Abnormality of liposaccharide metabolism (HP:0010968)6.18017045
4Abnormality of glycosphingolipid metabolism (HP:0004343)6.18017045
5Atonic seizures (HP:0010819)5.49623003
6Epileptic encephalopathy (HP:0200134)4.72075849
7Focal seizures (HP:0007359)4.64065091
8Myokymia (HP:0002411)4.59713706
9Febrile seizures (HP:0002373)4.44822766
10Hyperventilation (HP:0002883)4.23958572
11Vacuolated lymphocytes (HP:0001922)4.23254941
12Absence seizures (HP:0002121)4.16955313
13Visual hallucinations (HP:0002367)4.16859874
14Pheochromocytoma (HP:0002666)4.04805641
15Dialeptic seizures (HP:0011146)3.86561705
16Neuroendocrine neoplasm (HP:0100634)3.85837757
17Disinhibition (HP:0000734)3.83309992
18Increased cerebral lipofuscin (HP:0011813)3.73391050
19Generalized tonic-clonic seizures (HP:0002069)3.59691716
20Apathy (HP:0000741)3.56562180
21Diminished motivation (HP:0000745)3.52345937
22Progressive cerebellar ataxia (HP:0002073)3.49923821
23Hypothermia (HP:0002045)3.47287966
24Neuronal loss in central nervous system (HP:0002529)3.41426592
25Dysostosis multiplex (HP:0000943)3.21240250
26Loss of speech (HP:0002371)3.20818865
27Abnormal hair whorl (HP:0010721)3.19949109
28Acute necrotizing encephalopathy (HP:0006965)3.17356352
29Polyphagia (HP:0002591)3.13584961
30Gait imbalance (HP:0002141)3.12036815
31Intention tremor (HP:0002080)3.06137879
32Abnormal eating behavior (HP:0100738)3.00009550
33Abnormal mitochondria in muscle tissue (HP:0008316)2.96305282
34Limb dystonia (HP:0002451)2.96051483
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.94817290
36Amblyopia (HP:0000646)2.94429430
37Progressive macrocephaly (HP:0004481)2.90042826
38Epileptiform EEG discharges (HP:0011182)2.88386214
39Inappropriate behavior (HP:0000719)2.86926196
40Medial flaring of the eyebrow (HP:0010747)2.86586950
41Supranuclear gaze palsy (HP:0000605)2.84551977
42Abnormality of polysaccharide metabolism (HP:0011012)2.77843426
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77843426
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77843426
45Congenital primary aphakia (HP:0007707)2.77767465
46Progressive inability to walk (HP:0002505)2.71417346
47Failure to thrive in infancy (HP:0001531)2.70519056
48Nephrogenic diabetes insipidus (HP:0009806)2.70458872
49EEG with generalized epileptiform discharges (HP:0011198)2.68208791
50Broad-based gait (HP:0002136)2.62887365
51Urinary glycosaminoglycan excretion (HP:0003541)2.62520036
52Mucopolysacchariduria (HP:0008155)2.62520036
53Truncal ataxia (HP:0002078)2.53500604
54Axonal loss (HP:0003447)2.53261021
55Agnosia (HP:0010524)2.52578330
56Hypsarrhythmia (HP:0002521)2.51076152
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50011755
58Anxiety (HP:0000739)2.49792806
59Mitochondrial inheritance (HP:0001427)2.49195344
60Inability to walk (HP:0002540)2.48681600
61Excessive salivation (HP:0003781)2.44595143
62Drooling (HP:0002307)2.44595143
63Impaired vibration sensation in the lower limbs (HP:0002166)2.42687269
64Cerebral hypomyelination (HP:0006808)2.42622860
65Acute encephalopathy (HP:0006846)2.39940164
66Ankle clonus (HP:0011448)2.38916487
67Poor suck (HP:0002033)2.36775481
68Gaze-evoked nystagmus (HP:0000640)2.32493222
69Akinesia (HP:0002304)2.32289400
70Blue irides (HP:0000635)2.30041625
71Action tremor (HP:0002345)2.28367222
72Dementia (HP:0000726)2.28142393
73Poor eye contact (HP:0000817)2.27465652
74Scanning speech (HP:0002168)2.26438247
75Neurofibrillary tangles (HP:0002185)2.26155435
76Progressive neurologic deterioration (HP:0002344)2.26020285
77Abnormality of the motor neurons (HP:0002450)2.24511550
78Abnormal neuron morphology (HP:0012757)2.24511550
79Absent speech (HP:0001344)2.23838615
80Cerebral inclusion bodies (HP:0100314)2.23070205
81Nuclear cataract (HP:0100018)2.22334901
82Spastic tetraparesis (HP:0001285)2.22325743
83Oligomenorrhea (HP:0000876)2.21823229
84Genital tract atresia (HP:0001827)2.18680427
85Increased serum pyruvate (HP:0003542)2.16285117
86Abnormality of glycolysis (HP:0004366)2.16285117
87Diplopia (HP:0000651)2.16156257
88Abnormality of binocular vision (HP:0011514)2.16156257
89Specific learning disability (HP:0001328)2.15985127
90Dysmetria (HP:0001310)2.15585484
91Depression (HP:0000716)2.15352534
92Vaginal atresia (HP:0000148)2.15199533
93Increased CSF lactate (HP:0002490)2.14882630
94Fetal akinesia sequence (HP:0001989)2.13666491
953-Methylglutaconic aciduria (HP:0003535)2.13221859
96Abnormality of the corticospinal tract (HP:0002492)2.12585608
97Dysdiadochokinesis (HP:0002075)2.12289683
98Esotropia (HP:0000565)2.11431885
99CNS hypomyelination (HP:0003429)2.10419713
100Sensorimotor neuropathy (HP:0007141)2.09247951
101Protruding tongue (HP:0010808)2.08996439
102Degeneration of the lateral corticospinal tracts (HP:0002314)2.05295437
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05295437
104Spastic gait (HP:0002064)2.04763594
105Atrophy/Degeneration involving motor neurons (HP:0007373)2.04470124
106Neoplasm of the peripheral nervous system (HP:0100007)2.04446860
107Termporal pattern (HP:0011008)2.03851285
108Insidious onset (HP:0003587)2.03851285
109Craniofacial dystonia (HP:0012179)2.03203796
110Impaired social interactions (HP:0000735)2.02775717
111Abnormal social behavior (HP:0012433)2.02775717
112Urinary urgency (HP:0000012)2.01565567
113Poor coordination (HP:0002370)2.01475662
114Delusions (HP:0000746)2.01226500
115Tetraplegia (HP:0002445)1.99632601
116Hand muscle atrophy (HP:0009130)1.98229950
117Generalized myoclonic seizures (HP:0002123)1.97992235
118Agitation (HP:0000713)1.95682135
119Mutism (HP:0002300)1.95528173
120Retinal atrophy (HP:0001105)1.94973445
121Peripheral hypomyelination (HP:0007182)1.94444524
122Status epilepticus (HP:0002133)1.94152822
123Resting tremor (HP:0002322)1.93623554
124Hyperthyroidism (HP:0000836)1.93387853
125Personality changes (HP:0000751)1.92345133
126Bradykinesia (HP:0002067)1.92072620
127Urinary bladder sphincter dysfunction (HP:0002839)1.90821266
128Autoamputation (HP:0001218)1.89497346
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89188915
130Abnormality of the anterior horn cell (HP:0006802)1.87827047
131Degeneration of anterior horn cells (HP:0002398)1.87827047
132Postural instability (HP:0002172)1.86989723
133Generalized aminoaciduria (HP:0002909)1.85651287
134Global brain atrophy (HP:0002283)1.85428861
135Psychosis (HP:0000709)1.84206736
136Spastic tetraplegia (HP:0002510)1.82845221
137Lower limb muscle weakness (HP:0007340)1.82583097
138Hypokinesia (HP:0002375)1.82552224
139Amyotrophic lateral sclerosis (HP:0007354)1.82347493
140Hepatocellular necrosis (HP:0001404)1.81789059
141Hypoventilation (HP:0002791)1.81304198
142Postural tremor (HP:0002174)1.79672053
143Abnormality of salivation (HP:0100755)1.79575777
144Myoclonus (HP:0001336)1.79164165
145Frequent falls (HP:0002359)1.78425026
146Focal dystonia (HP:0004373)1.77748144
147Muscular hypotonia of the trunk (HP:0008936)1.77648640
148Torticollis (HP:0000473)1.77441114
149Optic disc pallor (HP:0000543)1.76811738
150Lissencephaly (HP:0001339)1.76028045
151Gait ataxia (HP:0002066)1.75302518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.37650647
2MAP3K123.71359447
3NTRK33.69518038
4MAP2K73.21809323
5EPHA43.11336628
6MAP3K42.92631669
7MAP3K92.66929990
8MARK12.59298300
9MINK12.37017782
10PLK22.35076108
11TESK12.20975692
12RIPK42.20535231
13ARAF2.01867924
14DAPK21.93820988
15PIM21.91100849
16NME21.89185697
17BMPR21.78155129
18CDK191.77724831
19DAPK11.76715653
20PINK11.76256007
21MAP2K41.74008236
22OXSR11.73133016
23TRIM281.71944488
24AKT31.67541822
25MAP4K21.61678391
26GRK51.59567785
27PRPF4B1.58140199
28NTRK11.52225944
29MAPK131.45254375
30MAP3K111.43056642
31LATS21.40379652
32TAOK11.39810600
33IRAK31.39025810
34BCR1.38602527
35NTRK21.37332304
36SIK31.29756297
37TNIK1.28826324
38CDK51.28409479
39PRKCG1.24400001
40KSR11.21414797
41SGK2231.20835776
42SGK4941.20835776
43ABL21.19387669
44ERBB31.19042552
45PAK61.15902882
46DDR21.15377874
47CCNB11.14726160
48KSR21.14697569
49CSNK1A1L1.13730966
50TSSK61.10280607
51PNCK1.09221637
52CAMK2A1.06369314
53BRAF1.03407652
54MAP3K51.00878213
55SGK21.00673088
56CAMK2B1.00616765
57CAMKK20.99140534
58PDK30.98118379
59PDK40.98118379
60GRK70.97356298
61PRKCE0.97077191
62NME10.96819388
63BMPR1B0.91543490
64MAP3K20.89873233
65TAOK20.88544837
66WNK30.87063327
67CAMK1D0.86570096
68CSNK1G20.83317560
69CDK140.82299779
70FRK0.81898263
71UHMK10.81077786
72CDK180.80726802
73SCYL20.79489931
74LIMK10.79333197
75DYRK30.77670666
76MOS0.76728794
77CSNK1G10.75931513
78FES0.75225211
79FGR0.74746440
80CAMK10.73843609
81CDK150.71761330
82PTK2B0.71524191
83NEK10.69948172
84MAP3K130.68321922
85ADRBK20.68213741
86SIK20.67531065
87PDK20.66830527
88PAK30.65980438
89ACVR1B0.64804946
90CAMKK10.64625659
91CAMK2D0.63117862
92MAP2K10.62290749
93DYRK1A0.61233058
94ERBB40.59383810
95CDK11A0.58718932
96MATK0.56798606
97TESK20.55693323
98ADRBK10.55515807
99DYRK20.54135513
100STK390.53167352
101SGK10.52858140
102PRKCH0.52658162
103CSNK1G30.52522434
104FER0.51877624
105PKN10.50878058
106CAMK2G0.50310253
107SGK30.49546715
108CAMK40.48203947
109MAP3K140.47268653
110INSRR0.46149182
111EIF2AK30.46048026
112ALK0.45506505
113RAF10.44622956
114CAMK1G0.43398115
115MST40.42318208
116PRKD30.42273952
117MYLK0.42007602
118IRAK20.41662899
119WNK40.41474518
120DYRK1B0.41457170
121CSNK1A10.41428365
122PRKCZ0.40317934
123BCKDK0.39679737
124PDPK10.37247764
125MAP3K10.37188822
126LMTK20.36878944
127PHKG20.36560012
128PHKG10.36560012
129TGFBR20.36124598
130ROCK20.35200424
131RPS6KA20.34754028
132PRKACA0.34744185
133YES10.34037971
134NEK60.33258576
135DAPK30.32856766
136PRKCA0.32634303
137PLK30.32456771
138FYN0.32309252

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047214.25375856
2Collecting duct acid secretion_Homo sapiens_hsa049664.02595566
3Nicotine addiction_Homo sapiens_hsa050333.76298987
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62759027
5* Oxidative phosphorylation_Homo sapiens_hsa001902.58143086
6* Vibrio cholerae infection_Homo sapiens_hsa051102.55796834
7GABAergic synapse_Homo sapiens_hsa047272.52932522
8Olfactory transduction_Homo sapiens_hsa047402.33917396
9Morphine addiction_Homo sapiens_hsa050322.27438781
10Circadian entrainment_Homo sapiens_hsa047132.21289264
11Amphetamine addiction_Homo sapiens_hsa050312.20493126
12Long-term potentiation_Homo sapiens_hsa047202.14469418
13Dopaminergic synapse_Homo sapiens_hsa047282.10506107
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.09059121
15Other glycan degradation_Homo sapiens_hsa005112.05771204
16Glutamatergic synapse_Homo sapiens_hsa047242.00357628
17Serotonergic synapse_Homo sapiens_hsa047261.88043423
18Taste transduction_Homo sapiens_hsa047421.84764706
19Parkinsons disease_Homo sapiens_hsa050121.75697590
20* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.73494907
21Insulin secretion_Homo sapiens_hsa049111.73195153
22Alzheimers disease_Homo sapiens_hsa050101.66126599
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66108544
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59634355
25Salivary secretion_Homo sapiens_hsa049701.57470627
26Cocaine addiction_Homo sapiens_hsa050301.55220940
27Cholinergic synapse_Homo sapiens_hsa047251.54809770
28Long-term depression_Homo sapiens_hsa047301.54422790
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54179102
30* Rheumatoid arthritis_Homo sapiens_hsa053231.52699438
31Renin secretion_Homo sapiens_hsa049241.50705356
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48672227
33Salmonella infection_Homo sapiens_hsa051321.39582302
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37058677
35* Phagosome_Homo sapiens_hsa041451.33323171
36Gastric acid secretion_Homo sapiens_hsa049711.27002929
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25931311
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17540546
39Calcium signaling pathway_Homo sapiens_hsa040201.17499729
40Huntingtons disease_Homo sapiens_hsa050161.13041815
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11744871
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10608290
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09939823
44Type I diabetes mellitus_Homo sapiens_hsa049401.09356245
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09043535
46Oxytocin signaling pathway_Homo sapiens_hsa049211.06010877
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01187770
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00296733
49Phototransduction_Homo sapiens_hsa047440.98922630
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96847856
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95853685
52Gap junction_Homo sapiens_hsa045400.93486046
53Vitamin B6 metabolism_Homo sapiens_hsa007500.93422133
54Legionellosis_Homo sapiens_hsa051340.92756183
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91152372
56Cardiac muscle contraction_Homo sapiens_hsa042600.89166811
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.86407176
58Pertussis_Homo sapiens_hsa051330.86168962
59GnRH signaling pathway_Homo sapiens_hsa049120.83555889
60Axon guidance_Homo sapiens_hsa043600.80889759
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80211733
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78189033
63cAMP signaling pathway_Homo sapiens_hsa040240.77327655
64Type II diabetes mellitus_Homo sapiens_hsa049300.75721378
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75352723
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74387260
67Regulation of autophagy_Homo sapiens_hsa041400.73078988
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71648481
69Estrogen signaling pathway_Homo sapiens_hsa049150.68919716
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66774937
71Osteoclast differentiation_Homo sapiens_hsa043800.66453868
72ErbB signaling pathway_Homo sapiens_hsa040120.66358812
73Pyruvate metabolism_Homo sapiens_hsa006200.64287946
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63815045
75beta-Alanine metabolism_Homo sapiens_hsa004100.63429727
76* Lysosome_Homo sapiens_hsa041420.62201223
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59172485
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.57825348
79Shigellosis_Homo sapiens_hsa051310.56819664
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56079046
81Glioma_Homo sapiens_hsa052140.55583374
82Proteasome_Homo sapiens_hsa030500.54728073
83Butanoate metabolism_Homo sapiens_hsa006500.53408590
84Pancreatic secretion_Homo sapiens_hsa049720.51907308
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51677275
86Glutathione metabolism_Homo sapiens_hsa004800.48280443
87Thyroid hormone synthesis_Homo sapiens_hsa049180.47226921
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46779403
89Tryptophan metabolism_Homo sapiens_hsa003800.46649299
90Melanogenesis_Homo sapiens_hsa049160.45634149
91Protein export_Homo sapiens_hsa030600.45464996
92Alcoholism_Homo sapiens_hsa050340.45269868
93Oocyte meiosis_Homo sapiens_hsa041140.43382659
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42223971
95Sulfur metabolism_Homo sapiens_hsa009200.42080042
96TNF signaling pathway_Homo sapiens_hsa046680.41194610
97Galactose metabolism_Homo sapiens_hsa000520.39398126
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39356765
99Ras signaling pathway_Homo sapiens_hsa040140.39172265
100African trypanosomiasis_Homo sapiens_hsa051430.38739882
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.38569561
102MAPK signaling pathway_Homo sapiens_hsa040100.38361286
103Prion diseases_Homo sapiens_hsa050200.37720763
104Steroid biosynthesis_Homo sapiens_hsa001000.37034106
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35014290
106Fatty acid elongation_Homo sapiens_hsa000620.34975457
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34072937
108Endocytosis_Homo sapiens_hsa041440.30921059
109Glucagon signaling pathway_Homo sapiens_hsa049220.30764492
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28176174
111Inositol phosphate metabolism_Homo sapiens_hsa005620.28082813
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.28063526
113Choline metabolism in cancer_Homo sapiens_hsa052310.27803934
114Carbon metabolism_Homo sapiens_hsa012000.27782025
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26560843
116Ether lipid metabolism_Homo sapiens_hsa005650.25855647
117Fatty acid biosynthesis_Homo sapiens_hsa000610.24835666
118Peroxisome_Homo sapiens_hsa041460.24742767
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24417699
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23501114
121Sphingolipid metabolism_Homo sapiens_hsa006000.22453980
122* Tuberculosis_Homo sapiens_hsa051520.21932898
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.21718854
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20390539
125Circadian rhythm_Homo sapiens_hsa047100.19713699
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19409354
127Mineral absorption_Homo sapiens_hsa049780.18017753

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