ATP7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1iron ion import (GO:0097286)4.88611819
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67392542
3modulation by symbiont of host defense response (GO:0052031)4.52078142
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.52078142
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.52078142
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.52078142
7modulation by symbiont of host immune response (GO:0052553)4.52078142
8positive regulation by symbiont of host defense response (GO:0052509)4.52078142
9phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.88935843
10positive regulation of muscle hypertrophy (GO:0014742)3.76031404
11positive regulation of cardiac muscle hypertrophy (GO:0010613)3.76031404
12neutrophil activation involved in immune response (GO:0002283)3.75536213
13ganglion development (GO:0061548)3.69733250
14regulation of interferon-beta biosynthetic process (GO:0045357)3.69241527
15definitive hemopoiesis (GO:0060216)3.61910339
16hepatocyte apoptotic process (GO:0097284)3.60709714
17positive regulation of gamma-delta T cell activation (GO:0046645)3.58415729
18regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.48530256
19positive regulation of interferon-alpha production (GO:0032727)3.44249067
20COPI coating of Golgi vesicle (GO:0048205)3.40313748
21Golgi transport vesicle coating (GO:0048200)3.40313748
22regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.38848760
23cytoplasmic mRNA processing body assembly (GO:0033962)3.32624943
24sequestering of metal ion (GO:0051238)3.28770293
25regulation of interferon-alpha production (GO:0032647)3.24914673
26cellular response to ethanol (GO:0071361)3.24669253
27establishment of protein localization to Golgi (GO:0072600)3.22698337
28ER overload response (GO:0006983)3.19365177
29protein targeting to Golgi (GO:0000042)3.18469823
30melanin biosynthetic process (GO:0042438)3.13791121
31microglial cell activation (GO:0001774)3.11659558
32histone H3-K4 trimethylation (GO:0080182)3.07287742
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07250699
34response to host immune response (GO:0052572)3.07250699
35retrograde transport, vesicle recycling within Golgi (GO:0000301)3.06739092
36regulation of somitogenesis (GO:0014807)3.05911490
37macrophage activation involved in immune response (GO:0002281)3.04405460
38regulation of B cell receptor signaling pathway (GO:0050855)3.00981056
39regulation of chemokine-mediated signaling pathway (GO:0070099)2.99867128
40erythrocyte development (GO:0048821)2.98277365
41monoubiquitinated protein deubiquitination (GO:0035520)2.96951705
42Golgi to endosome transport (GO:0006895)2.95032862
43histamine secretion (GO:0001821)2.94443998
44nuclear pore organization (GO:0006999)2.92401563
45detection of external biotic stimulus (GO:0098581)2.92344531
46positive regulation of granulocyte differentiation (GO:0030854)2.91558494
47protoporphyrinogen IX metabolic process (GO:0046501)2.91233838
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90842424
49response to peptidoglycan (GO:0032494)2.88738295
50regulation of mononuclear cell migration (GO:0071675)2.85132329
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83782584
52response to host (GO:0075136)2.83782584
53response to host defenses (GO:0052200)2.83782584
54positive regulation of cardiac muscle cell differentiation (GO:2000727)2.80885081
55negative regulation of peptidyl-lysine acetylation (GO:2000757)2.79603055
56embryonic hemopoiesis (GO:0035162)2.78848301
57interleukin-6-mediated signaling pathway (GO:0070102)2.77827862
58platelet-derived growth factor receptor signaling pathway (GO:0048008)2.77259874
59developmental pigmentation (GO:0048066)2.75101304
60regulation of cardiac muscle hypertrophy (GO:0010611)2.75043583
61myeloid cell development (GO:0061515)2.74399127
62neutrophil activation (GO:0042119)2.73498306
63positive regulation of interferon-beta production (GO:0032728)2.72893742
64type B pancreatic cell development (GO:0003323)2.72399158
65cellular response to arsenic-containing substance (GO:0071243)2.71919809
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70946686
67I-kappaB phosphorylation (GO:0007252)2.70653538
68histone mRNA catabolic process (GO:0071044)2.69945628
69positive regulation of SMAD protein import into nucleus (GO:0060391)2.69730050
70neutrophil mediated immunity (GO:0002446)2.69159934
71regulation of muscle hypertrophy (GO:0014743)2.68943795
72positive regulation of cellular amide metabolic process (GO:0034250)2.68816921
73melanin metabolic process (GO:0006582)2.68779260
74B cell receptor signaling pathway (GO:0050853)2.68078388
75response to lipoprotein particle (GO:0055094)2.67187995
76granulocyte activation (GO:0036230)2.66283536
77erythrocyte maturation (GO:0043249)2.65206990
78myeloid leukocyte mediated immunity (GO:0002444)2.64310639
79regulation of mast cell activation involved in immune response (GO:0033006)2.64227630
80exocrine pancreas development (GO:0031017)2.63569153
81prostate gland growth (GO:0060736)2.58301150
82macrophage activation (GO:0042116)2.58148096
83neural tube formation (GO:0001841)2.57221094
84negative regulation of systemic arterial blood pressure (GO:0003085)2.56417319
85regulation of sarcomere organization (GO:0060297)2.56318497
86eosinophil chemotaxis (GO:0048245)2.55783892
87axon extension involved in axon guidance (GO:0048846)2.55531614
88neuron projection extension involved in neuron projection guidance (GO:1902284)2.55531614
89histamine transport (GO:0051608)2.54356350
90T cell mediated immunity (GO:0002456)2.50724788
91regulation of SMAD protein import into nucleus (GO:0060390)2.50207172
92response to interleukin-15 (GO:0070672)2.49868163
93regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.49019840
94negative regulation of mast cell activation (GO:0033004)2.47432773
95detection of other organism (GO:0098543)2.47162730
96cell adhesion mediated by integrin (GO:0033627)2.46623079
97* cellular copper ion homeostasis (GO:0006878)2.46092358
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.46077424
99negative regulation of T-helper cell differentiation (GO:0045623)2.46077424
100positive regulation of erythrocyte differentiation (GO:0045648)2.45410110
101sequestering of extracellular ligand from receptor (GO:0035581)2.45333611
102T-helper 1 type immune response (GO:0042088)2.44266364
103regulation of dendritic cell antigen processing and presentation (GO:0002604)2.44193468
104germinal center formation (GO:0002467)2.44104898
105detection of biotic stimulus (GO:0009595)2.43437570
106positive regulation of chemokine biosynthetic process (GO:0045080)2.42846460
107embryonic camera-type eye morphogenesis (GO:0048596)2.41049155
108N-terminal protein amino acid acetylation (GO:0006474)2.41040233
109regulation of mast cell degranulation (GO:0043304)2.40773609
110histone lysine demethylation (GO:0070076)2.40582016
111nuclear pore complex assembly (GO:0051292)2.40260197
112production of molecular mediator involved in inflammatory response (GO:0002532)2.39124266
113dorsal/ventral axis specification (GO:0009950)2.38221257
114regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.37925665
115positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.37850713
116secondary metabolite biosynthetic process (GO:0044550)2.36173764
117retina vasculature morphogenesis in camera-type eye (GO:0061299)2.35352150
118histone demethylation (GO:0016577)2.34787175
119establishment of skin barrier (GO:0061436)2.34754011
120histone H3-K36 demethylation (GO:0070544)2.34592552
121nerve growth factor signaling pathway (GO:0038180)2.34483592
122wound healing, spreading of epidermal cells (GO:0035313)2.33848753
123macroautophagy (GO:0016236)2.33733188
124negative regulation of bone resorption (GO:0045779)2.33420680
125hypotonic response (GO:0006971)2.32522886
126replicative senescence (GO:0090399)2.31851666
127detection of molecule of bacterial origin (GO:0032490)2.31461330
128protein targeting to lysosome (GO:0006622)2.31457945
129establishment of protein localization to vacuole (GO:0072666)2.31457945
130protein targeting to vacuole (GO:0006623)2.31457945
131oxygen transport (GO:0015671)2.31284715
132positive regulation of cell size (GO:0045793)2.30594046
133interkinetic nuclear migration (GO:0022027)2.30401220
134regulation of gamma-delta T cell activation (GO:0046643)2.30185858
135positive regulation of hormone biosynthetic process (GO:0046886)2.30071419
136positive regulation vascular endothelial growth factor production (GO:0010575)2.29915245
137regulation of RNA export from nucleus (GO:0046831)2.29894334
138blood vessel maturation (GO:0001955)2.28997981
139regulation of MHC class I biosynthetic process (GO:0045343)2.28756088
140peptidyl-lysine trimethylation (GO:0018023)2.28308617
141positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.27580501
142positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.27580501
143positive regulation of mitotic sister chromatid separation (GO:1901970)2.27580501
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.27538536
145positive regulation of digestive system process (GO:0060456)2.27447651
146lipid translocation (GO:0034204)2.25964506
147phospholipid translocation (GO:0045332)2.25964506
148response to muramyl dipeptide (GO:0032495)2.25566058
149cellular response to ATP (GO:0071318)2.24468587
150pore complex assembly (GO:0046931)2.24235015
151positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23728019
152cellular response to vitamin D (GO:0071305)2.23527513
153positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.23234463
154positive regulation of macrophage cytokine production (GO:0060907)2.22738479
155cellular extravasation (GO:0045123)2.18484574
156fibroblast migration (GO:0010761)2.18461090
157substrate-dependent cell migration (GO:0006929)2.17830463
158phagocytosis, engulfment (GO:0006911)2.16841558
159positive regulation of chemokine production (GO:0032722)2.15909327
160regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.15623828
161glandular epithelial cell development (GO:0002068)2.15206364
162natural killer cell mediated cytotoxicity (GO:0042267)2.15205410
163natural killer cell mediated immunity (GO:0002228)2.15205410
164eosinophil migration (GO:0072677)2.14935422
165vascular endothelial growth factor signaling pathway (GO:0038084)2.14247335
166phenol-containing compound catabolic process (GO:0019336)2.13060045
167positive regulation of actin filament depolymerization (GO:0030836)2.12879358
168regulation of mast cell activation (GO:0033003)2.12813549
169positive regulation of interleukin-12 production (GO:0032735)2.11682302
170positive regulation of antigen processing and presentation (GO:0002579)2.09709912
171regulation of integrin-mediated signaling pathway (GO:2001044)2.08632967
172positive regulation of smooth muscle cell migration (GO:0014911)2.07106864
173dendritic cell migration (GO:0036336)2.06100786
174lipopolysaccharide-mediated signaling pathway (GO:0031663)2.05655794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.32437514
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.56877618
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.80206301
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.61172869
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.41097208
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.95306256
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.90049153
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.85734302
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73091468
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.71987758
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63196249
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.41903802
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41749492
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.33168333
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23187740
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.13067415
17SCL_19346495_ChIP-Seq_HPC-7_Human2.04090578
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.03508388
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97956094
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.95516435
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93884613
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91045051
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.84865794
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82844088
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81542277
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81358238
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79786909
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.79133627
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78123103
30VDR_24787735_ChIP-Seq_THP-1_Human1.76736389
31RUNX_20019798_ChIP-Seq_JUKART_Human1.73525353
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72830402
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.67957261
34BRD4_25478319_ChIP-Seq_HGPS_Human1.67660728
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.65616712
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65486316
37GATA1_19941826_ChIP-Seq_K562_Human1.65329045
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64176224
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.63346280
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.61352625
41CJUN_26792858_Chip-Seq_BT549_Human1.60480578
42* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55509454
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55443895
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53311557
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.50593451
46GATA2_19941826_ChIP-Seq_K562_Human1.48836052
47ER_23166858_ChIP-Seq_MCF-7_Human1.46039782
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44248516
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44248516
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42862722
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42853993
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42328154
53* TFEB_21752829_ChIP-Seq_HELA_Human1.42140617
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41424116
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41424116
56CLOCK_20551151_ChIP-Seq_293T_Human1.40217934
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37611611
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35709921
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35292309
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34885679
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34380738
62TP53_16413492_ChIP-PET_HCT116_Human1.32245088
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31314492
64GATA1_22025678_ChIP-Seq_K562_Human1.30928911
65SOX2_20726797_ChIP-Seq_SW620_Human1.30736316
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30476151
67IGF1R_20145208_ChIP-Seq_DFB_Human1.29932278
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28375525
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26604566
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25965702
71SALL4_22934838_ChIP-ChIP_CD34+_Human1.24840655
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23068886
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23061866
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22494361
75STAT3_23295773_ChIP-Seq_U87_Human1.22350062
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.21948345
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21096190
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19075916
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18868616
80PU_27001747_Chip-Seq_BMDM_Mouse1.18832208
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.18377410
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18189941
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16916282
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15761285
85* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15382345
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14365617
87SMAD4_21799915_ChIP-Seq_A2780_Human1.11725493
88AR_21572438_ChIP-Seq_LNCaP_Human1.11204058
89MYB_26560356_Chip-Seq_TH1_Human1.10810243
90KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10737892
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08144983
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.07421372
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07219163
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06867203
95SPI1_23127762_ChIP-Seq_K562_Human1.06616394
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.05571646
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04974676
98FUS_26573619_Chip-Seq_HEK293_Human1.02863768
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01445844
100GBX2_23144817_ChIP-Seq_PC3_Human1.01264836
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01156387
102TAF15_26573619_Chip-Seq_HEK293_Human0.98901100
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.98248580
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96552008
105BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96502006
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96501698
107P300_19829295_ChIP-Seq_ESCs_Human0.96095891
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95795475
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95462986
110CRX_20693478_ChIP-Seq_RETINA_Mouse0.95373503
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.95146716
112TP53_18474530_ChIP-ChIP_U2OS_Human0.94922920
113GATA3_26560356_Chip-Seq_TH2_Human0.94770391
114CDX2_22108803_ChIP-Seq_LS180_Human0.94066739
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.93943092
116SPI1_23547873_ChIP-Seq_NB4_Human0.93176613
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93008127
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92620154
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92198901
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.92007477
121AHR_22903824_ChIP-Seq_MCF-7_Human0.90580067
122TP63_23658742_ChIP-Seq_EP156T_Human0.89563182
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88598905
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.87420015
125* ELK1_19687146_ChIP-ChIP_HELA_Human0.87089275
126GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86466293
127GATA3_27048872_Chip-Seq_THYMUS_Human0.85958370
128MYB_26560356_Chip-Seq_TH2_Human0.85142907
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84400721
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83213234
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82530282
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82050597
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81008260
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80712817
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79717070
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.79571452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005408_hypopigmentation3.36738917
2MP0008057_abnormal_DNA_replication3.35498954
3MP0003656_abnormal_erythrocyte_physiolo3.31939746
4MP0000569_abnormal_digit_pigmentation3.12961228
5MP0002877_abnormal_melanocyte_morpholog2.84360314
6MP0005257_abnormal_intraocular_pressure2.64072362
7* MP0000372_irregular_coat_pigmentation2.56429210
8MP0010352_gastrointestinal_tract_polyps2.55791683
9MP0010386_abnormal_urinary_bladder2.53588376
10MP0005083_abnormal_biliary_tract2.37292739
11MP0003300_gastrointestinal_ulcer2.28943122
12MP0004381_abnormal_hair_follicle2.27111924
13MP0010307_abnormal_tumor_latency2.17061451
14MP0010234_abnormal_vibrissa_follicle2.12629346
15MP0002163_abnormal_gland_morphology2.09738293
16MP0002166_altered_tumor_susceptibility2.07111345
17* MP0000371_diluted_coat_color2.03738332
18MP0003183_abnormal_peptide_metabolism2.03227706
19MP0005367_renal/urinary_system_phenotyp1.97396566
20MP0000516_abnormal_urinary_system1.97396566
21MP0005379_endocrine/exocrine_gland_phen1.96508592
22* MP0008438_abnormal_cutaneous_collagen1.95150297
23MP0004883_abnormal_blood_vessel1.88102039
24* MP0005171_absent_coat_pigmentation1.82740486
25MP0002006_tumorigenesis1.81079890
26* MP0005275_abnormal_skin_tensile1.79511751
27MP0003191_abnormal_cellular_cholesterol1.76862037
28MP0004272_abnormal_basement_membrane1.74651589
29MP0004147_increased_porphyrin_level1.72901109
30MP0005058_abnormal_lysosome_morphology1.72644707
31MP0001835_abnormal_antigen_presentation1.71345978
32MP0002938_white_spotting1.65581119
33MP0000015_abnormal_ear_pigmentation1.57327253
34MP0004808_abnormal_hematopoietic_stem1.57059220
35MP0003303_peritoneal_inflammation1.55976358
36MP0003763_abnormal_thymus_physiology1.53513687
37MP0005164_abnormal_response_to1.53203197
38MP0005248_abnormal_Harderian_gland1.53080543
39MP0001800_abnormal_humoral_immune1.52488813
40MP0004484_altered_response_of1.50673573
41MP0002148_abnormal_hypersensitivity_rea1.50641895
42MP0002277_abnormal_respiratory_mucosa1.48014015
43MP0005076_abnormal_cell_differentiation1.47472766
44MP0000685_abnormal_immune_system1.46274922
45MP0000465_gastrointestinal_hemorrhage1.39554199
46MP0002419_abnormal_innate_immunity1.37224409
47MP0006054_spinal_hemorrhage1.35677802
48MP0003705_abnormal_hypodermis_morpholog1.35251726
49MP0003828_pulmonary_edema1.34684382
50MP0000427_abnormal_hair_cycle1.33823849
51MP0003122_maternal_imprinting1.31778211
52MP0010678_abnormal_skin_adnexa1.29400309
53MP0000538_abnormal_urinary_bladder1.27686224
54MP0003436_decreased_susceptibility_to1.26863988
55MP0003121_genomic_imprinting1.26128812
56MP0003172_abnormal_lysosome_physiology1.25221030
57MP0008260_abnormal_autophagy1.24279173
58MP0005197_abnormal_uvea_morphology1.23526304
59MP0002168_other_aberrant_phenotype1.23434909
60MP0003221_abnormal_cardiomyocyte_apopto1.22948242
61MP0002009_preneoplasia1.21495371
62* MP0001186_pigmentation_phenotype1.19754342
63MP0008007_abnormal_cellular_replicative1.19406567
64MP0003448_altered_tumor_morphology1.18987966
65MP0005174_abnormal_tail_pigmentation1.18678482
66MP0002420_abnormal_adaptive_immunity1.18553128
67MP0000733_abnormal_muscle_development1.17882892
68MP0001879_abnormal_lymphatic_vessel1.16806515
69MP0001819_abnormal_immune_cell1.16485337
70MP0003566_abnormal_cell_adhesion1.16095613
71MP0002398_abnormal_bone_marrow1.14827716
72MP0005023_abnormal_wound_healing1.12890305
73MP0005220_abnormal_exocrine_pancreas1.09928867
74MP0006082_CNS_inflammation1.09769926
75* MP0002075_abnormal_coat/hair_pigmentati1.08553126
76MP0003091_abnormal_cell_migration1.08358949
77MP0002396_abnormal_hematopoietic_system1.07553786
78MP0000767_abnormal_smooth_muscle1.07405221
79MP0003195_calcinosis1.06885342
80MP0003890_abnormal_embryonic-extraembry1.06599068
81MP0004947_skin_inflammation1.04885591
82MP0009785_altered_susceptibility_to1.04261737
83MP0002452_abnormal_antigen_presenting1.04144930
84MP0001790_abnormal_immune_system1.03895221
85MP0005387_immune_system_phenotype1.03895221
86MP0009764_decreased_sensitivity_to1.03266067
87MP0001958_emphysema1.02832468
88MP0000689_abnormal_spleen_morphology1.02115186
89MP0005000_abnormal_immune_tolerance1.01556174
90MP0005075_abnormal_melanosome_morpholog1.00519628
91MP0002095_abnormal_skin_pigmentation0.99742873
92MP0003950_abnormal_plasma_membrane0.98740960
93MP0001324_abnormal_eye_pigmentation0.98611855
94MP0000383_abnormal_hair_follicle0.98581425
95MP0002722_abnormal_immune_system0.98561792
96MP0001533_abnormal_skeleton_physiology0.98510333
97MP0002998_abnormal_bone_remodeling0.97080612
98MP0005671_abnormal_response_to0.96821173
99MP0003866_abnormal_defecation0.94565994
100MP0002693_abnormal_pancreas_physiology0.94024309
101MP0003045_fibrosis0.93882139
102MP0001299_abnormal_eye_distance/0.92243482
103MP0002638_abnormal_pupillary_reflex0.92013909
104MP0000716_abnormal_immune_system0.91747643
105MP0003123_paternal_imprinting0.89768941
106MP0003453_abnormal_keratinocyte_physiol0.89590338
107MP0004264_abnormal_extraembryonic_tissu0.89124620
108MP0004134_abnormal_chest_morphology0.88169072
109MP0005310_abnormal_salivary_gland0.87034507
110MP0002177_abnormal_outer_ear0.85736090
111MP0002928_abnormal_bile_duct0.83590424
112MP0000858_altered_metastatic_potential0.83529671
113* MP0001191_abnormal_skin_condition0.83008317
114MP0003385_abnormal_body_wall0.82124348
115MP0005464_abnormal_platelet_physiology0.81716677
116MP0003724_increased_susceptibility_to0.81191191
117* MP0005390_skeleton_phenotype0.81186650
118MP0005025_abnormal_response_to0.80641681
119MP0000613_abnormal_salivary_gland0.80256543
120* MP0002098_abnormal_vibrissa_morphology0.79759936
121MP0001545_abnormal_hematopoietic_system0.79490121
122MP0005397_hematopoietic_system_phenotyp0.79490121
123* MP0001175_abnormal_lung_morphology0.79048261
124* MP0005508_abnormal_skeleton_morphology0.78877558
125MP0003787_abnormal_imprinting0.78485720
126MP0001756_abnormal_urination0.78399535
127MP0001915_intracranial_hemorrhage0.77953345
128MP0000703_abnormal_thymus_morphology0.77724974
129MP0009278_abnormal_bone_marrow0.76715312
130MP0002405_respiratory_system_inflammati0.76648690
131MP0002723_abnormal_immune_serum0.76644298
132MP0009115_abnormal_fat_cell0.76254928
133MP0001845_abnormal_inflammatory_respons0.75369099
134MP0002429_abnormal_blood_cell0.75261041
135MP0000432_abnormal_head_morphology0.75163865
136MP0005451_abnormal_body_composition0.74124065
137MP0002896_abnormal_bone_mineralization0.73950480
138MP0002796_impaired_skin_barrier0.73718333
139* MP0005503_abnormal_tendon_morphology0.73532358
140MP0003795_abnormal_bone_structure0.73135042
141MP0008004_abnormal_stomach_pH0.72153954
142MP0005409_darkened_coat_color0.71314721
143MP0003959_abnormal_lean_body0.71222411
144MP0001216_abnormal_epidermal_layer0.69312265
145MP0004084_abnormal_cardiac_muscle0.68083507
146MP0001784_abnormal_fluid_regulation0.67323396

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)4.61379919
2Decreased circulating renin level (HP:0003351)4.39726699
3Hypokalemic alkalosis (HP:0001949)3.79564819
4Hyperactive renin-angiotensin system (HP:0000841)3.78069231
5Abnormality of the right ventricle (HP:0001707)3.69556043
6Asymmetry of the thorax (HP:0001555)3.65013614
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.35275655
8Poikilocytosis (HP:0004447)3.29038472
9Gastrointestinal infarctions (HP:0005244)3.22714805
10Cutaneous melanoma (HP:0012056)3.14545024
11T lymphocytopenia (HP:0005403)3.12284240
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.09500222
13Subacute progressive viral hepatitis (HP:0006572)2.98113506
14Hyperaldosteronism (HP:0000859)2.93702314
15Abnormality of T cell number (HP:0011839)2.91308526
16Abnormality of chloride homeostasis (HP:0011422)2.89773496
17Curly hair (HP:0002212)2.81624500
18Peritonitis (HP:0002586)2.81222070
19Recurrent abscess formation (HP:0002722)2.77205551
20Macroorchidism (HP:0000053)2.74444877
21Hypokalemia (HP:0002900)2.72403625
22Hyperkalemia (HP:0002153)2.71327841
23Neoplasm of the adrenal cortex (HP:0100641)2.68017301
24Dysostosis multiplex (HP:0000943)2.63904415
25Spondylolisthesis (HP:0003302)2.61114988
26Aplasia/Hypoplasia of the macula (HP:0008059)2.59565325
27Neoplasm of the heart (HP:0100544)2.55727354
28Vacuolated lymphocytes (HP:0001922)2.55298168
29Vertebral arch anomaly (HP:0008438)2.53490864
30Recurrent bacterial skin infections (HP:0005406)2.52462798
31Chronic bronchitis (HP:0004469)2.47757234
32Eczematoid dermatitis (HP:0000976)2.44032176
33Recurrent skin infections (HP:0001581)2.42267214
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39537505
35Short 4th metacarpal (HP:0010044)2.39537505
36Acanthocytosis (HP:0001927)2.38583961
37Abnormality of secondary sexual hair (HP:0009888)2.36134228
38Abnormality of the axillary hair (HP:0100134)2.36134228
39Deformed sella turcica (HP:0002681)2.35496492
40Generalized hypopigmentation of hair (HP:0011358)2.34977967
41Systemic lupus erythematosus (HP:0002725)2.33213975
42Renal salt wasting (HP:0000127)2.32641923
43Aplasia/Hypoplasia affecting the retina (HP:0008061)2.32501882
44Polycythemia (HP:0001901)2.30126079
45Rectal prolapse (HP:0002035)2.28088473
46Abnormality of the fingertips (HP:0001211)2.26809105
47Increased IgE level (HP:0003212)2.26747624
48Hyponatremia (HP:0002902)2.26585856
49Thoracolumbar scoliosis (HP:0002944)2.25691134
50Viral hepatitis (HP:0006562)2.24217397
51Pelvic girdle muscle weakness (HP:0003749)2.23830149
52* Spontaneous hematomas (HP:0007420)2.20663853
53Truncal obesity (HP:0001956)2.18384603
54Hypochromic microcytic anemia (HP:0004840)2.18118170
55Aplasia/Hypoplasia of the fovea (HP:0008060)2.18099672
56Hypoplasia of the fovea (HP:0007750)2.18099672
57Autoimmune thrombocytopenia (HP:0001973)2.17997931
58Microcytic anemia (HP:0001935)2.17400613
59Conjugated hyperbilirubinemia (HP:0002908)2.16124767
60Albinism (HP:0001022)2.15922100
61Osteomalacia (HP:0002749)2.15693193
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.15110148
63Transitional cell carcinoma of the bladder (HP:0006740)2.14374058
64Enlarged penis (HP:0000040)2.13104699
65Recurrent fungal infections (HP:0002841)2.12480194
66Abnormality of the sella turcica (HP:0002679)2.12426764
67Thyroiditis (HP:0100646)2.11963582
68Osteolytic defects of the hand bones (HP:0009699)2.10740321
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.10740321
70Diastasis recti (HP:0001540)2.09798318
71Abnormality of potassium homeostasis (HP:0011042)2.09464846
72Urinary glycosaminoglycan excretion (HP:0003541)2.09448702
73Mucopolysacchariduria (HP:0008155)2.09448702
74Thick nail (HP:0001805)2.09326306
75Recurrent viral infections (HP:0004429)2.08321334
76Prostate neoplasm (HP:0100787)2.08309183
77Cervical subluxation (HP:0003308)2.07637637
78Deep philtrum (HP:0002002)2.04695584
79Overgrowth (HP:0001548)2.04410172
80Narrow palate (HP:0000189)2.02270151
81Keratoconjunctivitis sicca (HP:0001097)2.01403655
82Autoimmune hemolytic anemia (HP:0001890)2.00788366
83Abnormality of the musculature of the pelvis (HP:0001469)1.99439503
84Abnormality of the hip-girdle musculature (HP:0001445)1.99439503
85Lip pit (HP:0100267)1.98905411
86Recurrent cutaneous fungal infections (HP:0011370)1.98681871
87Chronic mucocutaneous candidiasis (HP:0002728)1.98681871
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98661736
89Gingivitis (HP:0000230)1.97275019
90Abnormality of cochlea (HP:0000375)1.97181249
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97095751
92Abnormality of polysaccharide metabolism (HP:0011012)1.97095751
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97095751
94Chest pain (HP:0100749)1.95327417
95Gingival bleeding (HP:0000225)1.94779447
96Fair hair (HP:0002286)1.94648857
97Volvulus (HP:0002580)1.93251391
98Retrobulbar optic neuritis (HP:0100654)1.90752314
99Optic neuritis (HP:0100653)1.90752314
100Aortic aneurysm (HP:0004942)1.90685408
101Hypoplastic labia majora (HP:0000059)1.90593062
102Papillary thyroid carcinoma (HP:0002895)1.89513879
103Abnormality of the nasal septum (HP:0000419)1.88855780
104Glomerulonephritis (HP:0000099)1.87956751
105Spinal cord lesions (HP:0100561)1.87799781
106Syringomyelia (HP:0003396)1.87799781
107Striae distensae (HP:0001065)1.87340874
108Cerebral aneurysm (HP:0004944)1.85771719
109Heterochromia iridis (HP:0001100)1.84267664
110Prominent nose (HP:0000448)1.84143679
111Congenital sensorineural hearing impairment (HP:0008527)1.83834170
112Absent frontal sinuses (HP:0002688)1.83827803
113Acute myeloid leukemia (HP:0004808)1.83715500
114Large earlobe (HP:0009748)1.82529431
115Abnormality of the fovea (HP:0000493)1.82066198
116Thyroid carcinoma (HP:0002890)1.81390970
117Termporal pattern (HP:0011008)1.81165719
118Insidious onset (HP:0003587)1.81165719
119Broad face (HP:0000283)1.81140620
120Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.81045691
121Leukocytosis (HP:0001974)1.80006351
122Abnormality of glycolipid metabolism (HP:0010969)1.79806321
123Abnormality of liposaccharide metabolism (HP:0010968)1.79806321
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.79806321
125Abnormality of the frontal sinuses (HP:0002687)1.79693037
126Abnormality of renin-angiotensin system (HP:0000847)1.78754113
127Increased cerebral lipofuscin (HP:0011813)1.78705833
128Recurrent bronchitis (HP:0002837)1.78443096
129Aortic dissection (HP:0002647)1.78214146
130Dilatation of the ascending aorta (HP:0005111)1.76933233
131Abnormality of macrophages (HP:0004311)1.76567148
132Keratoconjunctivitis (HP:0001096)1.76051204
133Submucous cleft hard palate (HP:0000176)1.75585332
134* Bladder neoplasm (HP:0009725)1.75488376
135* Bladder carcinoma (HP:0002862)1.75488376
136Hypoglycemic seizures (HP:0002173)1.74954499
137Recurrent gram-negative bacterial infections (HP:0005420)1.74295855
138Metabolic alkalosis (HP:0200114)1.73679372
139IgA deficiency (HP:0002720)1.72633680
140Craniofacial hyperostosis (HP:0004493)1.72461046
141Hip dysplasia (HP:0001385)1.70488746
142Micronodular cirrhosis (HP:0001413)1.69717310
143Generalized hypopigmentation (HP:0007513)1.69399060
144Abnormality of the labia majora (HP:0012881)1.69086140
145* Osteomyelitis (HP:0002754)1.68473726
146Intestinal fistula (HP:0100819)1.67803193
147Lower limb hyperreflexia (HP:0002395)1.67798448
148Arterial thrombosis (HP:0004420)1.67644655
149Blue irides (HP:0000635)1.67047167
150Basal ganglia calcification (HP:0002135)1.66421374
151Esophageal varix (HP:0002040)1.66116320
152Myositis (HP:0100614)1.65947774
153Abnormality of T cells (HP:0002843)1.65884766
154Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65736364
155Insulin-resistant diabetes mellitus (HP:0000831)1.65256198
156Increased neuronal autofluorescent lipopigment (HP:0002074)1.65151024
157Abnormality of sodium homeostasis (HP:0010931)1.65023044
158Aqueductal stenosis (HP:0002410)1.64790224
159Hypoplasia of the iris (HP:0007676)1.64745533
160Abnormality of the vasculature of the conjunctiva (HP:0008054)1.64481675
161Uterine leiomyosarcoma (HP:0002891)1.63731974
162Leiomyosarcoma (HP:0100243)1.63731974
163Periodontitis (HP:0000704)1.63424030
164Premature rupture of membranes (HP:0001788)1.63279239
165Sandal gap (HP:0001852)1.62893524
166Thickened calvaria (HP:0002684)1.62880232
167Abnormality of the lumbar spine (HP:0100712)1.62427502
168Low anterior hairline (HP:0000294)1.62347865
169Orchitis (HP:0100796)1.61739952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.34460090
2LATS13.30986387
3FGFR22.82193920
4LMTK22.67581627
5NUAK12.59263023
6INSRR2.56038891
7EPHA32.32036181
8FGFR32.05222688
9PIK3CG1.96307431
10MST1R1.94602167
11MAP3K141.80151852
12TGFBR21.79621720
13RIPK41.79522822
14CLK11.78354383
15STK31.77384060
16BRD41.67007422
17CDK121.64978548
18ERBB31.63052145
19CHUK1.57198274
20EIF2AK11.57116272
21MET1.54727692
22CAMK1D1.53091598
23PTK61.51195720
24JAK21.47125868
25TAOK31.43738999
26MAP2K31.41436170
27MARK31.37057327
28SCYL21.36527523
29TYK21.34854879
30ZAK1.28444462
31TBK11.26578287
32SGK21.26485161
33NEK91.26118280
34FLT31.19846862
35KIT1.19582197
36STK101.16976956
37PDGFRA1.16624355
38RET1.16275275
39PTK2B1.15419913
40BTK1.15180830
41IKBKB1.13148990
42MAP3K21.12065849
43KSR11.12046090
44CCNB11.11490305
45PASK1.08808006
46MAP3K61.08356796
47JAK11.07135444
48MAP2K41.04954524
49MAP3K31.03503241
50JAK31.01789978
51KSR21.01775558
52MAPK151.01468299
53IRAK41.01100762
54SYK0.96911025
55CAMK1G0.95944961
56ERN10.94773216
57MAP3K40.94048570
58ACVR1B0.93225229
59CAMK40.93098194
60BMPR1B0.89399284
61CAMKK20.88453240
62STK38L0.87866916
63ITK0.85652169
64SGK30.84925467
65IKBKE0.83509783
66MAP3K10.83415719
67BRSK20.82915902
68TTN0.82537456
69IRAK30.82497717
70FER0.81385147
71TRPM70.81294490
72GRK60.81213399
73PRKAA20.80788852
74MAP4K10.80574618
75BMPR20.79769790
76PDGFRB0.78299897
77CSF1R0.76043670
78BMX0.75857643
79RAF10.75331006
80STK240.74884643
81EPHB10.74869625
82MELK0.73653248
83EIF2AK20.72097196
84STK40.69987646
85MAPK70.69967611
86CDK60.69380889
87DMPK0.68710538
88MAP3K100.68531527
89PLK30.68015802
90RPS6KA40.68014060
91YES10.67645714
92EEF2K0.67386849
93GRK70.67309568
94TGFBR10.67308337
95MTOR0.65713902
96ADRBK20.65390470
97RPS6KA50.64392109
98HIPK20.63528451
99DDR20.62779766
100PBK0.62722829
101MAP2K10.62051832
102EIF2AK30.61564003
103MAP3K70.61216970
104MAPK120.58887283
105PIM10.57920153
106MAP3K50.57572577
107BCR0.57564486
108TEC0.57031125
109AKT30.55610792
110MAPK130.54490791
111PRKCE0.54450173
112PRKAA10.54034706
113CSK0.52982325
114PAK30.52671841
115PLK20.51272577
116MATK0.51185035
117INSR0.50852893
118IRAK20.48660133
119IGF1R0.48519425
120DYRK30.48322016
121BLK0.48310209
122FGR0.47875216
123SRPK10.47515408
124PRKG20.46760066
125CDK90.45998659
126LCK0.45204645
127GSK3A0.45172873
128WNK10.44297287
129ATM0.44119643
130NLK0.43795424
131PRPF4B0.43678503
132PKN20.42802091
133PRKD30.42705697
134ERBB20.42506906
135LYN0.41570374
136SGK10.39772146
137ADRBK10.39438721
138TXK0.38843637
139HCK0.37282117
140MST40.37175558
141PRKCH0.36388242
142ATR0.35789002
143MAPKAPK20.33969178
144FGFR40.33507754
145IRAK10.33401318
146ZAP700.33372536
147EGFR0.33134216

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041422.03675690
2Glycosaminoglycan degradation_Homo sapiens_hsa005311.96596670
3Leishmaniasis_Homo sapiens_hsa051401.94776266
4Maturity onset diabetes of the young_Homo sapiens_hsa049501.91596653
5Adherens junction_Homo sapiens_hsa045201.88439479
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82739683
7Staphylococcus aureus infection_Homo sapiens_hsa051501.78448644
8Non-small cell lung cancer_Homo sapiens_hsa052231.75559143
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75470073
10Legionellosis_Homo sapiens_hsa051341.75112347
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.71687810
12Malaria_Homo sapiens_hsa051441.58703927
13Pertussis_Homo sapiens_hsa051331.50414405
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50283581
15Alcoholism_Homo sapiens_hsa050341.48722573
16Osteoclast differentiation_Homo sapiens_hsa043801.48265319
17Toxoplasmosis_Homo sapiens_hsa051451.42444296
18Rheumatoid arthritis_Homo sapiens_hsa053231.41149158
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40866605
20Other glycan degradation_Homo sapiens_hsa005111.38988432
21Protein export_Homo sapiens_hsa030601.38886403
22Prostate cancer_Homo sapiens_hsa052151.37228266
23Phagosome_Homo sapiens_hsa041451.35454256
24Small cell lung cancer_Homo sapiens_hsa052221.33444603
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32860930
26Measles_Homo sapiens_hsa051621.32690253
27TNF signaling pathway_Homo sapiens_hsa046681.30721424
28Tuberculosis_Homo sapiens_hsa051521.30189057
29Type I diabetes mellitus_Homo sapiens_hsa049401.30123766
30Graft-versus-host disease_Homo sapiens_hsa053321.29813619
31Acute myeloid leukemia_Homo sapiens_hsa052211.25818865
32Influenza A_Homo sapiens_hsa051641.25815716
33Allograft rejection_Homo sapiens_hsa053301.25603452
34Antigen processing and presentation_Homo sapiens_hsa046121.25525002
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24936835
36MicroRNAs in cancer_Homo sapiens_hsa052061.23474869
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18597491
38Focal adhesion_Homo sapiens_hsa045101.17981406
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16710027
40Proteoglycans in cancer_Homo sapiens_hsa052051.14449048
41Renin-angiotensin system_Homo sapiens_hsa046141.14125485
42T cell receptor signaling pathway_Homo sapiens_hsa046601.13934908
43Hepatitis B_Homo sapiens_hsa051611.10192149
44Pancreatic cancer_Homo sapiens_hsa052121.10062218
45Chronic myeloid leukemia_Homo sapiens_hsa052201.09844312
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09452384
47Apoptosis_Homo sapiens_hsa042101.09428687
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.09119483
49Vibrio cholerae infection_Homo sapiens_hsa051101.09029425
50Herpes simplex infection_Homo sapiens_hsa051681.07552460
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06589654
52African trypanosomiasis_Homo sapiens_hsa051431.04908780
53Amoebiasis_Homo sapiens_hsa051461.04481063
54Type II diabetes mellitus_Homo sapiens_hsa049301.04058034
55TGF-beta signaling pathway_Homo sapiens_hsa043501.03804389
56Sphingolipid signaling pathway_Homo sapiens_hsa040711.01906431
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01602976
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01292577
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00848494
60Viral myocarditis_Homo sapiens_hsa054161.00208606
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99983552
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98697776
63Glioma_Homo sapiens_hsa052140.97219328
64Hematopoietic cell lineage_Homo sapiens_hsa046400.96123542
65ECM-receptor interaction_Homo sapiens_hsa045120.94847239
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91503911
67Endometrial cancer_Homo sapiens_hsa052130.90386517
68HIF-1 signaling pathway_Homo sapiens_hsa040660.90171623
69Salmonella infection_Homo sapiens_hsa051320.89206487
70Chemokine signaling pathway_Homo sapiens_hsa040620.87585052
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86779340
72Prolactin signaling pathway_Homo sapiens_hsa049170.86414774
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85697850
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.85122244
75Choline metabolism in cancer_Homo sapiens_hsa052310.84695404
76Viral carcinogenesis_Homo sapiens_hsa052030.84461005
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83943218
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83724589
79FoxO signaling pathway_Homo sapiens_hsa040680.83491164
80VEGF signaling pathway_Homo sapiens_hsa043700.82326471
81Melanoma_Homo sapiens_hsa052180.82149901
82Dorso-ventral axis formation_Homo sapiens_hsa043200.79276491
83p53 signaling pathway_Homo sapiens_hsa041150.78560758
84* Mineral absorption_Homo sapiens_hsa049780.78449289
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75701505
86ErbB signaling pathway_Homo sapiens_hsa040120.75670114
87Hepatitis C_Homo sapiens_hsa051600.73127992
88Pathways in cancer_Homo sapiens_hsa052000.72910609
89B cell receptor signaling pathway_Homo sapiens_hsa046620.71375636
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70841000
91mTOR signaling pathway_Homo sapiens_hsa041500.69742353
92Autoimmune thyroid disease_Homo sapiens_hsa053200.69575415
93Tyrosine metabolism_Homo sapiens_hsa003500.69282149
94Primary immunodeficiency_Homo sapiens_hsa053400.68467031
95Platelet activation_Homo sapiens_hsa046110.68362366
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68145890
97Sphingolipid metabolism_Homo sapiens_hsa006000.67677546
98ABC transporters_Homo sapiens_hsa020100.67532468
99Shigellosis_Homo sapiens_hsa051310.67442448
100Circadian rhythm_Homo sapiens_hsa047100.66783574
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66765203
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65254951
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.64591208
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64500164
105Insulin resistance_Homo sapiens_hsa049310.64088167
106Renal cell carcinoma_Homo sapiens_hsa052110.64053743
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62173284
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.62055081
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.61943200
110Systemic lupus erythematosus_Homo sapiens_hsa053220.60414539
111HTLV-I infection_Homo sapiens_hsa051660.60388024
112Notch signaling pathway_Homo sapiens_hsa043300.59284264
113Hippo signaling pathway_Homo sapiens_hsa043900.59113362
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57439786
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57130154
116Colorectal cancer_Homo sapiens_hsa052100.56867488
117Thyroid cancer_Homo sapiens_hsa052160.56226314
118Asthma_Homo sapiens_hsa053100.55883255
119Lysine degradation_Homo sapiens_hsa003100.55704394
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.55376084
121Selenocompound metabolism_Homo sapiens_hsa004500.54227338
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53039981
123GnRH signaling pathway_Homo sapiens_hsa049120.53031665
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52929859
125Inositol phosphate metabolism_Homo sapiens_hsa005620.52782388
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52596213
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52462239
128Regulation of autophagy_Homo sapiens_hsa041400.51708694
129Insulin signaling pathway_Homo sapiens_hsa049100.48700024
130Long-term depression_Homo sapiens_hsa047300.48540298

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