ATP7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.04972452
2L-phenylalanine catabolic process (GO:0006559)7.04972452
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.68420334
4L-phenylalanine metabolic process (GO:0006558)6.68420334
5aromatic amino acid family catabolic process (GO:0009074)6.28742372
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22694396
7tryptophan metabolic process (GO:0006568)5.82716496
8tryptophan catabolic process (GO:0006569)5.78749299
9indole-containing compound catabolic process (GO:0042436)5.78749299
10indolalkylamine catabolic process (GO:0046218)5.78749299
11kynurenine metabolic process (GO:0070189)5.64944984
12high-density lipoprotein particle remodeling (GO:0034375)5.60259087
13bile acid biosynthetic process (GO:0006699)5.56820006
14urea cycle (GO:0000050)5.45114476
15urea metabolic process (GO:0019627)5.45114476
16glyoxylate metabolic process (GO:0046487)5.39208883
17cysteine metabolic process (GO:0006534)5.37720744
18negative regulation of fibrinolysis (GO:0051918)5.35771583
19alpha-linolenic acid metabolic process (GO:0036109)5.29674196
20sulfur amino acid catabolic process (GO:0000098)5.22290871
21regulation of fibrinolysis (GO:0051917)5.20386667
22regulation of protein activation cascade (GO:2000257)5.08593377
23peptidyl-glutamic acid carboxylation (GO:0017187)5.03923899
24protein carboxylation (GO:0018214)5.03923899
25regulation of cholesterol esterification (GO:0010872)5.00467718
26reverse cholesterol transport (GO:0043691)4.99912844
27nitrogen cycle metabolic process (GO:0071941)4.98362945
28serine family amino acid catabolic process (GO:0009071)4.92014070
29ethanol oxidation (GO:0006069)4.91919269
30tyrosine metabolic process (GO:0006570)4.89764652
31bile acid metabolic process (GO:0008206)4.87002176
32plasma lipoprotein particle remodeling (GO:0034369)4.81884669
33protein-lipid complex remodeling (GO:0034368)4.81884669
34macromolecular complex remodeling (GO:0034367)4.81884669
35lysine metabolic process (GO:0006553)4.75422111
36lysine catabolic process (GO:0006554)4.75422111
37imidazole-containing compound metabolic process (GO:0052803)4.72664869
38regulation of complement activation (GO:0030449)4.72614043
39complement activation, alternative pathway (GO:0006957)4.71857059
40phospholipid efflux (GO:0033700)4.70952558
41aromatic amino acid family metabolic process (GO:0009072)4.68669477
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65113871
43regulation of triglyceride catabolic process (GO:0010896)4.58255361
44cholesterol efflux (GO:0033344)4.56033362
45plasma lipoprotein particle assembly (GO:0034377)4.52522704
46alpha-amino acid catabolic process (GO:1901606)4.42932304
47acylglycerol homeostasis (GO:0055090)4.42918690
48triglyceride homeostasis (GO:0070328)4.42918690
49homocysteine metabolic process (GO:0050667)4.42113167
50very-low-density lipoprotein particle assembly (GO:0034379)4.40358222
51negative regulation of sterol transport (GO:0032372)4.39652356
52negative regulation of cholesterol transport (GO:0032375)4.39652356
53amino-acid betaine metabolic process (GO:0006577)4.38813786
54glycine metabolic process (GO:0006544)4.33520925
55indolalkylamine metabolic process (GO:0006586)4.32006694
56regulation of bile acid biosynthetic process (GO:0070857)4.28396635
57response to nitrosative stress (GO:0051409)4.24430475
58plasma lipoprotein particle clearance (GO:0034381)4.21019910
59serine family amino acid metabolic process (GO:0009069)4.15160600
60bile acid and bile salt transport (GO:0015721)4.13523895
61low-density lipoprotein particle remodeling (GO:0034374)4.10220576
62cellular biogenic amine catabolic process (GO:0042402)4.09559153
63amine catabolic process (GO:0009310)4.09559153
64aldehyde catabolic process (GO:0046185)4.05937687
65benzene-containing compound metabolic process (GO:0042537)4.05197861
66cellular amino acid catabolic process (GO:0009063)4.04791385
67positive regulation of lipoprotein lipase activity (GO:0051006)4.03608606
68positive regulation of triglyceride lipase activity (GO:0061365)4.03608606
69cellular glucuronidation (GO:0052695)4.02580850
70drug catabolic process (GO:0042737)4.00747076
71phospholipid homeostasis (GO:0055091)3.97604446
72glutamate metabolic process (GO:0006536)3.95196232
73protein-lipid complex assembly (GO:0065005)3.92900718
74regulation of cholesterol biosynthetic process (GO:0045540)3.88075740
75plasma lipoprotein particle organization (GO:0071827)3.88067875
76blood coagulation, intrinsic pathway (GO:0007597)3.87396889
77serine family amino acid biosynthetic process (GO:0009070)3.85646891
78cellular ketone body metabolic process (GO:0046950)3.82991273
79arginine metabolic process (GO:0006525)3.79343237
80regulation of cholesterol metabolic process (GO:0090181)3.78657933
81ethanol metabolic process (GO:0006067)3.75687740
82embryonic retina morphogenesis in camera-type eye (GO:0060059)3.75592549
83cholesterol homeostasis (GO:0042632)3.73978371
84cellular modified amino acid catabolic process (GO:0042219)3.71056494
85intestinal cholesterol absorption (GO:0030299)3.69597548
86sterol homeostasis (GO:0055092)3.65905202
87coenzyme catabolic process (GO:0009109)3.65480380
88lipoprotein metabolic process (GO:0042157)3.59159525
89protein-lipid complex subunit organization (GO:0071825)3.57607034
90positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.57016097
91protein activation cascade (GO:0072376)3.55961622
92organic acid catabolic process (GO:0016054)3.55922615
93carboxylic acid catabolic process (GO:0046395)3.55922615
94flavonoid metabolic process (GO:0009812)3.54935256
95primary alcohol catabolic process (GO:0034310)3.54535204
96uronic acid metabolic process (GO:0006063)3.53506302
97glucuronate metabolic process (GO:0019585)3.53506302
98fibrinolysis (GO:0042730)3.53042182
99complement activation, classical pathway (GO:0006958)3.52798318
100positive regulation of lipid catabolic process (GO:0050996)3.52443595
101negative regulation of protein activation cascade (GO:2000258)3.48422601
102negative regulation of lipase activity (GO:0060192)3.48079371
103proline metabolic process (GO:0006560)3.37557445
104regulation of cholesterol homeostasis (GO:2000188)3.27271427
105cilium or flagellum-dependent cell motility (GO:0001539)3.25118462
106intestinal absorption (GO:0050892)3.23158446
107regulation of apoptotic cell clearance (GO:2000425)3.20293991
108regulation of plasminogen activation (GO:0010755)3.02686995
109vitamin transmembrane transport (GO:0035461)2.99138199
110proline biosynthetic process (GO:0006561)2.98940991
1114-hydroxyproline metabolic process (GO:0019471)2.98219285
112chromosome condensation (GO:0030261)2.90722717
113nephron epithelium morphogenesis (GO:0072088)2.89813829
114nephron tubule morphogenesis (GO:0072078)2.89813829
115drug transmembrane transport (GO:0006855)2.87785303
116phosphatidylethanolamine biosynthetic process (GO:0006646)2.86226115
117bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84904625
118lung epithelium development (GO:0060428)2.84331136
119axonemal dynein complex assembly (GO:0070286)2.82531654
120sperm motility (GO:0030317)2.79901994
121regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.78827280
122fusion of sperm to egg plasma membrane (GO:0007342)2.78064659
123COPII vesicle coating (GO:0048208)2.75137441
124histone H3-K9 demethylation (GO:0033169)2.75046278
125peptidyl-glutamic acid modification (GO:0018200)2.74550211
126DNA packaging (GO:0006323)2.71319410
127regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.67805064
128lipoprotein transport (GO:0042953)2.60437496
129negative regulation of blood coagulation (GO:0030195)2.59781575
130negative regulation of hemostasis (GO:1900047)2.59781575
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.59675501
132sperm capacitation (GO:0048240)2.57695780
133diacylglycerol metabolic process (GO:0046339)2.56647179
134positive regulation of hormone metabolic process (GO:0032352)2.56391506
135epoxygenase P450 pathway (GO:0019373)2.55009538
136phosphatidylethanolamine metabolic process (GO:0046337)2.54356067
137cholesterol transport (GO:0030301)2.52385246
138sterol transport (GO:0015918)2.52385246
139heme transport (GO:0015886)2.52140812
140negative regulation of fatty acid biosynthetic process (GO:0045717)2.48494041
141nuclear pore complex assembly (GO:0051292)2.48356086
142drug transport (GO:0015893)2.46201695
143regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.45141246
144glutamine family amino acid biosynthetic process (GO:0009084)2.43941322
145negative regulation of sodium ion transport (GO:0010766)2.42485333
146positive regulation of steroid metabolic process (GO:0045940)2.41298787
147biotin metabolic process (GO:0006768)2.41105512
148seminiferous tubule development (GO:0072520)2.40195965
149positive regulation of dendritic spine morphogenesis (GO:0061003)2.39640020
150exogenous drug catabolic process (GO:0042738)2.37996910
151response to vitamin A (GO:0033189)2.37524053
152negative regulation of coagulation (GO:0050819)2.33465146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.15708177
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09777283
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.06635448
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.31837873
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.38228580
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.93153685
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81225530
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.35764380
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.22825869
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.33088664
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.13217161
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.39179076
13E2F7_22180533_ChIP-Seq_HELA_Human2.22215043
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7948416
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99995570
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97463966
17GATA1_22025678_ChIP-Seq_K562_Human1.89187196
18AR_21572438_ChIP-Seq_LNCaP_Human1.85753138
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68872560
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65936783
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65868449
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60820841
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.57143935
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54838141
25CLOCK_20551151_ChIP-Seq_293T_Human1.53909459
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48936282
27* FOXA2_19822575_ChIP-Seq_HepG2_Human1.48053110
28* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46438589
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45149459
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.43834034
31HTT_18923047_ChIP-ChIP_STHdh_Human1.34444982
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33786697
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.31807598
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.29599449
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28113084
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27810774
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26219336
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22826089
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22826089
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22109685
41CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20163197
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19898706
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18313234
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18014589
45AHR_22903824_ChIP-Seq_MCF-7_Human1.17901692
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14133903
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.13192046
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12098795
49* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12069865
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10759480
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09994982
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09328696
53STAT3_23295773_ChIP-Seq_U87_Human1.09293541
54GATA4_25053715_ChIP-Seq_YYC3_Human1.07558840
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06692067
56SMAD4_21741376_ChIP-Seq_HESCs_Human1.06270974
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05435775
58FUS_26573619_Chip-Seq_HEK293_Human1.04806999
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.03746224
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03451219
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.03255123
62* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02553880
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02368500
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02113847
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.00749572
66FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99459679
67SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99036940
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98996983
69TP53_16413492_ChIP-PET_HCT116_Human0.98034605
70VDR_22108803_ChIP-Seq_LS180_Human0.97720865
71PIAS1_25552417_ChIP-Seq_VCAP_Human0.96910506
72IGF1R_20145208_ChIP-Seq_DFB_Human0.96845909
73SMAD3_21741376_ChIP-Seq_EPCs_Human0.96406881
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96164623
75TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94955639
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94896089
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94849439
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94608006
79TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93956172
80DROSHA_22980978_ChIP-Seq_HELA_Human0.92703188
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92247937
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91971827
83GBX2_23144817_ChIP-Seq_PC3_Human0.90473100
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90069523
85E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89558575
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.89534950
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89521706
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85201888
89SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83603627
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83269376
91SMAD4_21799915_ChIP-Seq_A2780_Human0.81825233
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81737118
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80718168
94TP53_18474530_ChIP-ChIP_U2OS_Human0.80656080
95RARA_24833708_ChIP-Seq_LIVER_Mouse0.80430645
96EZH2_22144423_ChIP-Seq_EOC_Human0.80288806
97ZNF263_19887448_ChIP-Seq_K562_Human0.79861551
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79619347
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79319138
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78976923
101TAF15_26573619_Chip-Seq_HEK293_Human0.78934810
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78880826
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78804424
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77454517
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76000863
106GATA1_19941826_ChIP-Seq_K562_Human0.74974791
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73971715
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.73909527
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.72440344
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72415963
111RARB_24833708_ChIP-Seq_LIVER_Mouse0.68615882
112AR_21909140_ChIP-Seq_LNCAP_Human0.67643140
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66846195
114AR_20517297_ChIP-Seq_VCAP_Human0.66338624
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65031078
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64699780
117IRF1_19129219_ChIP-ChIP_H3396_Human0.63192272
118* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62773294
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.62098427
120GATA6_25053715_ChIP-Seq_YYC3_Human0.61069752
121SRF_21415370_ChIP-Seq_HL-1_Mouse0.60905058
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57435951
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.56078564
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.55617719
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.55116508
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.54566809
127* STAT1_17558387_ChIP-Seq_HELA_Human0.54095258
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.53121085
129* GATA2_19941826_ChIP-Seq_K562_Human0.52397701
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50028678
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.48142755
132CEBPB_22108803_ChIP-Seq_LS180_Human0.47966520
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46925624
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.46523974
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46285453
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.46141422
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.46102242
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.45248736
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.44819845
140ERG_20517297_ChIP-Seq_VCAP_Human0.44105920
141TAF2_19829295_ChIP-Seq_ESCs_Human0.43634459
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.43480937
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.43368508
144EGR1_19032775_ChIP-ChIP_M12_Human0.43193514
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.39873767
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.39856790
147ERA_21632823_ChIP-Seq_H3396_Human0.39783738
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.39671496
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.39083201
150PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.39065884
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.38723276
152P53_21459846_ChIP-Seq_SAOS-2_Human0.38472703
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.38066772
154KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.37911078
155MYC_27129775_Chip-Seq_CORNEA_Mouse0.37866770
156STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37829867
157NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.37474779
158ELF1_17652178_ChIP-ChIP_JURKAT_Human0.35181454
159BCOR_27268052_Chip-Seq_Bcells_Human0.35126027
160GATA3_21867929_ChIP-Seq_CD8_Mouse0.34623619
161SOX11_22085726_ChIP-Seq_ESNs_Mouse0.33791069
162* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.33649574
163OCT4_18692474_ChIP-Seq_MEFs_Mouse0.33528043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17138944
2MP0005360_urolithiasis7.18519044
3MP0005085_abnormal_gallbladder_physiolo6.13623799
4MP0005365_abnormal_bile_salt5.81362260
5MP0008875_abnormal_xenobiotic_pharmacok5.33061068
6MP0003806_abnormal_nucleotide_metabolis4.65262747
7MP0010329_abnormal_lipoprotein_level3.46234328
8MP0003252_abnormal_bile_duct3.44737240
9MP0005083_abnormal_biliary_tract3.41398449
10MP0009840_abnormal_foam_cell3.10926820
11MP0003122_maternal_imprinting2.85811653
12MP0001666_abnormal_nutrient_absorption2.76882764
13MP0005332_abnormal_amino_acid2.52678225
14MP0003191_abnormal_cellular_cholesterol2.36912682
15MP0005410_abnormal_fertilization2.33832765
16MP0004019_abnormal_vitamin_homeostasis2.21180470
17MP0003195_calcinosis2.10802367
18MP0009697_abnormal_copulation2.06344936
19MP0005377_hearing/vestibular/ear_phenot2.06336086
20MP0003878_abnormal_ear_physiology2.06336086
21* MP0000609_abnormal_liver_physiology2.00743218
22MP0003656_abnormal_erythrocyte_physiolo2.00519152
23MP0004272_abnormal_basement_membrane2.00159980
24MP0002138_abnormal_hepatobiliary_system1.99123471
25MP0002118_abnormal_lipid_homeostasis1.94467492
26MP0005409_darkened_coat_color1.88864210
27MP0004782_abnormal_surfactant_physiolog1.83170186
28MP0002132_abnormal_respiratory_system1.83078608
29MP0005319_abnormal_enzyme/_coenzyme1.76149249
30MP0001764_abnormal_homeostasis1.71978411
31MP0003186_abnormal_redox_activity1.69254504
32MP0002249_abnormal_larynx_morphology1.63443279
33MP0003868_abnormal_feces_composition1.59203980
34MP0010368_abnormal_lymphatic_system1.58922314
35MP0003942_abnormal_urinary_system1.54832485
36MP0003011_delayed_dark_adaptation1.53623808
37MP0003567_abnormal_fetal_cardiomyocyte1.49518374
38MP0005584_abnormal_enzyme/coenzyme_acti1.45467573
39MP0002089_abnormal_postnatal_growth/wei1.43708700
40MP0003941_abnormal_skin_development1.41925379
41MP0003698_abnormal_male_reproductive1.40013951
42MP0003890_abnormal_embryonic-extraembry1.38565599
43MP0005187_abnormal_penis_morphology1.36704186
44MP0003937_abnormal_limbs/digits/tail_de1.36207710
45MP0003123_paternal_imprinting1.28414045
46MP0009643_abnormal_urine_homeostasis1.27455948
47MP0001929_abnormal_gametogenesis1.25302035
48MP0004147_increased_porphyrin_level1.22266837
49MP0009384_cardiac_valve_regurgitation1.20191818
50MP0003315_abnormal_perineum_morphology1.18652188
51MP0005647_abnormal_sex_gland1.18431719
52MP0000678_abnormal_parathyroid_gland1.15404487
53MP0005451_abnormal_body_composition1.15323564
54MP0000537_abnormal_urethra_morphology1.15299860
55* MP0005636_abnormal_mineral_homeostasis1.13740529
56* MP0000598_abnormal_liver_morphology1.11168359
57MP0005220_abnormal_exocrine_pancreas1.08348634
58MP0003121_genomic_imprinting1.06080555
59MP0003385_abnormal_body_wall1.04717031
60MP0003943_abnormal_hepatobiliary_system1.03584688
61* MP0002161_abnormal_fertility/fecundity1.01755499
62MP0000534_abnormal_ureter_morphology0.99951642
63MP0009780_abnormal_chondrocyte_physiolo0.99158141
64* MP0005408_hypopigmentation0.98454406
65MP0009053_abnormal_anal_canal0.98340499
66MP0005076_abnormal_cell_differentiation0.97849629
67MP0002086_abnormal_extraembryonic_tissu0.97125138
68MP0003119_abnormal_digestive_system0.97052020
69MP0002084_abnormal_developmental_patter0.96782041
70MP0009764_decreased_sensitivity_to0.96099416
71MP0002938_white_spotting0.94971305
72MP0002282_abnormal_trachea_morphology0.93956348
73MP0001293_anophthalmia0.93845014
74MP0006036_abnormal_mitochondrial_physio0.88763574
75MP0004133_heterotaxia0.88687649
76MP0002160_abnormal_reproductive_system0.88076519
77MP0001672_abnormal_embryogenesis/_devel0.87741269
78MP0005380_embryogenesis_phenotype0.87741269
79MP0009763_increased_sensitivity_to0.87637189
80MP0002254_reproductive_system_inflammat0.87159040
81MP0005376_homeostasis/metabolism_phenot0.86714051
82MP0009703_decreased_birth_body0.85790863
83MP0002088_abnormal_embryonic_growth/wei0.84396363
84MP0003984_embryonic_growth_retardation0.84049596
85MP0008961_abnormal_basal_metabolism0.83178568
86MP0001697_abnormal_embryo_size0.82567082
87MP0001730_embryonic_growth_arrest0.81989726
88MP0001270_distended_abdomen0.81886838
89MP0005266_abnormal_metabolism0.80918024
90MP0001756_abnormal_urination0.80852573
91MP0001177_atelectasis0.80571352
92MP0002233_abnormal_nose_morphology0.80148502
93MP0009765_abnormal_xenobiotic_induced0.80001015
94MP0003935_abnormal_craniofacial_develop0.79836435
95* MP0009642_abnormal_blood_homeostasis0.78634697
96MP0002092_abnormal_eye_morphology0.77098670
97MP0010030_abnormal_orbit_morphology0.75598126
98MP0000566_synostosis0.75064066
99MP0000653_abnormal_sex_gland0.73375266
100MP0002085_abnormal_embryonic_tissue0.73180747
101MP0003861_abnormal_nervous_system0.73125772
102MP0002210_abnormal_sex_determination0.73112602
103MP0008872_abnormal_physiological_respon0.72681623
104MP0001286_abnormal_eye_development0.71705422
105MP0003879_abnormal_hair_cell0.69253329
106* MP0003632_abnormal_nervous_system0.69035736
107MP0005084_abnormal_gallbladder_morpholo0.68666331
108MP0008469_abnormal_protein_level0.68260746
109MP0004270_analgesia0.66981226
110MP0001145_abnormal_male_reproductive0.65357747
111MP0006035_abnormal_mitochondrial_morpho0.60975726
112MP0002909_abnormal_adrenal_gland0.60858135
113MP0001661_extended_life_span0.58227266
114MP0002078_abnormal_glucose_homeostasis0.58097105
115MP0004264_abnormal_extraembryonic_tissu0.56271572
116* MP0005395_other_phenotype0.54834405
117MP0005334_abnormal_fat_pad0.54270212
118* MP0003718_maternal_effect0.53964335
119MP0005248_abnormal_Harderian_gland0.53428599
120MP0004043_abnormal_pH_regulation0.51820137
121MP0002136_abnormal_kidney_physiology0.51440953
122MP0009672_abnormal_birth_weight0.50212196
123MP0008995_early_reproductive_senescence0.49054701
124MP0003300_gastrointestinal_ulcer0.44257914
125MP0003115_abnormal_respiratory_system0.43876699
126MP0003705_abnormal_hypodermis_morpholog0.43426106
127MP0005551_abnormal_eye_electrophysiolog0.43040390
128MP0000639_abnormal_adrenal_gland0.42436424
129MP0003690_abnormal_glial_cell0.41252684
130MP0005464_abnormal_platelet_physiology0.41194614
131MP0003638_abnormal_response/metabolism_0.41105637
132MP0002971_abnormal_brown_adipose0.37219635
133MP0002876_abnormal_thyroid_physiology0.36873338
134MP0002295_abnormal_pulmonary_circulatio0.36680838
135MP0002168_other_aberrant_phenotype0.36322195
136MP0006054_spinal_hemorrhage0.36145876
137MP0001324_abnormal_eye_pigmentation0.36031923
138MP0005535_abnormal_body_temperature0.35052920
139MP0003953_abnormal_hormone_level0.35039551
140MP0005448_abnormal_energy_balance0.34189952
141MP0001915_intracranial_hemorrhage0.32870151
142MP0002653_abnormal_ependyma_morphology0.32777285
143MP0004883_abnormal_blood_vessel0.31568356
144* MP0000604_amyloidosis0.31135376
145MP0008873_increased_physiological_sensi0.30395715
146MP0003724_increased_susceptibility_to0.29213971
147MP0005075_abnormal_melanosome_morpholog0.27225625
148MP0000613_abnormal_salivary_gland0.27049250
149MP0002133_abnormal_respiratory_system0.26407118
150MP0005388_respiratory_system_phenotype0.26407118
151MP0001881_abnormal_mammary_gland0.26172981
152* MP0003699_abnormal_female_reproductive0.25891818
153MP0005379_endocrine/exocrine_gland_phen0.25151654
154MP0002822_catalepsy0.24491348
155MP0002697_abnormal_eye_size0.24480895
156MP0002135_abnormal_kidney_morphology0.23496306
157MP0005670_abnormal_white_adipose0.23262396
158MP0005166_decreased_susceptibility_to0.23184156
159MP0008789_abnormal_olfactory_epithelium0.22868892

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.80204517
2Deep venous thrombosis (HP:0002625)6.77902146
3Hypobetalipoproteinemia (HP:0003563)6.53844304
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.43898993
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.38457341
6Prolonged partial thromboplastin time (HP:0003645)5.99894362
7Xanthomatosis (HP:0000991)5.51032552
8Hyperlipoproteinemia (HP:0010980)4.77329906
9Conjugated hyperbilirubinemia (HP:0002908)4.68562233
10Hypolipoproteinemia (HP:0010981)4.65251911
11Complement deficiency (HP:0004431)4.50360225
12Joint hemorrhage (HP:0005261)4.50187093
13Hyperammonemia (HP:0001987)4.24551512
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.20158003
15Hyperglycinemia (HP:0002154)4.19356000
16Epidermoid cyst (HP:0200040)4.09700469
17Fat malabsorption (HP:0002630)4.02841494
18Hyperglycinuria (HP:0003108)4.01859500
19Abnormality of the common coagulation pathway (HP:0010990)3.98031115
20Hyperbilirubinemia (HP:0002904)3.95948518
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.91472181
22Abnormality of pyrimidine metabolism (HP:0004353)3.83601922
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.79202297
24Abnormality of methionine metabolism (HP:0010901)3.78661602
25Abnormality of serine family amino acid metabolism (HP:0010894)3.78073987
26Abnormality of glycine metabolism (HP:0010895)3.78073987
27Acanthocytosis (HP:0001927)3.76332722
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.72871403
29Hypoalphalipoproteinemia (HP:0003233)3.71254883
30Hypoglycemic coma (HP:0001325)3.69896813
31Ketosis (HP:0001946)3.64550157
32Poikilocytosis (HP:0004447)3.40968566
33Abnormality of the intrinsic pathway (HP:0010989)3.37396936
34Hypercholesterolemia (HP:0003124)3.32561529
35Delayed CNS myelination (HP:0002188)3.32189486
36Abnormality of fatty-acid metabolism (HP:0004359)3.30319778
37Hypochromic microcytic anemia (HP:0004840)3.25995377
38Hepatocellular carcinoma (HP:0001402)3.21547641
39Metabolic acidosis (HP:0001942)3.20658538
40Abnormality of nucleobase metabolism (HP:0010932)3.16386304
41Abnormality of the heme biosynthetic pathway (HP:0010472)3.07576984
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.06904424
43Abnormality of complement system (HP:0005339)3.06233411
44Alkalosis (HP:0001948)3.05353104
45Ileus (HP:0002595)2.94331172
46Hyperactive renin-angiotensin system (HP:0000841)2.89551208
47Abnormality of serum amino acid levels (HP:0003112)2.85561735
48Steatorrhea (HP:0002570)2.84598948
49Abnormality of purine metabolism (HP:0004352)2.82778496
50Vascular calcification (HP:0004934)2.81258736
51Cholecystitis (HP:0001082)2.78142779
52Abnormal gallbladder physiology (HP:0012438)2.78142779
53Hepatoblastoma (HP:0002884)2.75366894
54Ketoacidosis (HP:0001993)2.74253397
55Broad palm (HP:0001169)2.70211122
56Cholelithiasis (HP:0001081)2.68052541
57Flat acetabular roof (HP:0003180)2.67886026
58Hypoglycemic seizures (HP:0002173)2.67640020
59Abnormal gallbladder morphology (HP:0012437)2.65656352
60Gout (HP:0001997)2.63035432
61Spastic diplegia (HP:0001264)2.59401148
62Reticulocytosis (HP:0001923)2.59068847
63Lethargy (HP:0001254)2.54601899
64Abnormality of carpal bone ossification (HP:0006257)2.51158377
65Spontaneous abortion (HP:0005268)2.47843540
66Renal salt wasting (HP:0000127)2.43011096
67Cardiovascular calcification (HP:0011915)2.42960560
68Hypokalemic alkalosis (HP:0001949)2.42806665
69Renal cortical cysts (HP:0000803)2.40289537
70Hypophosphatemic rickets (HP:0004912)2.38517272
71Malnutrition (HP:0004395)2.37761831
72Hemorrhage of the eye (HP:0011885)2.36559364
73Glomerulonephritis (HP:0000099)2.36249825
74Abnormal tarsal ossification (HP:0008369)2.35616106
75Opisthotonus (HP:0002179)2.32713038
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.30829104
77Cerebral edema (HP:0002181)2.29696502
78Dicarboxylic aciduria (HP:0003215)2.28721275
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28721275
80Enlarged kidneys (HP:0000105)2.27663848
81Brushfield spots (HP:0001088)2.26659500
82Abnormality of the nasal septum (HP:0000419)2.26115462
83Skin nodule (HP:0200036)2.23976689
84Vomiting (HP:0002013)2.17617333
85Broad alveolar ridges (HP:0000187)2.15990533
86Abnormality of the gallbladder (HP:0005264)2.14893342
87Myocardial infarction (HP:0001658)2.13606214
88Dynein arm defect of respiratory motile cilia (HP:0012255)2.12517498
89Absent/shortened dynein arms (HP:0200106)2.12517498
90Abnormal respiratory motile cilium physiology (HP:0012261)2.11983348
91Tubulointerstitial nephritis (HP:0001970)2.11361828
92Bifid scrotum (HP:0000048)2.09295072
93Facial shape deformation (HP:0011334)2.08409619
94Potter facies (HP:0002009)2.08409619
95Abnormal ventriculo-arterial connection (HP:0011563)2.07801958
96Transposition of the great arteries (HP:0001669)2.07801958
97Abnormal connection of the cardiac segments (HP:0011545)2.07801958
98Right ventricular cardiomyopathy (HP:0011663)2.06768902
99Papillary thyroid carcinoma (HP:0002895)2.06310383
100Menorrhagia (HP:0000132)2.05898004
101* Esophageal varix (HP:0002040)2.05706409
102Chronic bronchitis (HP:0004469)2.04294972
103Proximal tubulopathy (HP:0000114)2.04047618
104Thrombophlebitis (HP:0004418)2.01619531
105Pancreatic islet-cell hyperplasia (HP:0004510)2.00864733
106Myelomeningocele (HP:0002475)2.00422601
107Abnormal hand bone ossification (HP:0010660)1.99907185
108Hyperaldosteronism (HP:0000859)1.99881094
109Sensorimotor neuropathy (HP:0007141)1.99806250
110Irritability (HP:0000737)1.99630795
111* Osteomalacia (HP:0002749)1.98468053
112Bicornuate uterus (HP:0000813)1.97844254
113Abnormality of iron homeostasis (HP:0011031)1.97209875
114Polycythemia (HP:0001901)1.96149770
115Rhinitis (HP:0012384)1.95410795
116Asymmetry of the thorax (HP:0001555)1.95329271
117Abnormality of chloride homeostasis (HP:0011422)1.95239648
118Midline defect of the nose (HP:0004122)1.94503701
119Hyponatremia (HP:0002902)1.93563516
120Gingival bleeding (HP:0000225)1.91457861
121Abnormal delivery (HP:0001787)1.91379781
122Generalized aminoaciduria (HP:0002909)1.90752695
123Pigmentary retinal degeneration (HP:0001146)1.90499208
124Retinal atrophy (HP:0001105)1.89887158
125Confusion (HP:0001289)1.89337885
126Respiratory distress (HP:0002098)1.88835899
127Chronic hepatic failure (HP:0100626)1.88369809
128Increased purine levels (HP:0004368)1.87967011
129Hyperuricemia (HP:0002149)1.87967011
130Widely patent fontanelles and sutures (HP:0004492)1.87459290
131Mitral stenosis (HP:0001718)1.87281375
132Abnormal ossification of hand bones (HP:0005921)1.86964918
133Systemic lupus erythematosus (HP:0002725)1.86664011
134Absent eyebrow (HP:0002223)1.86612816
135Abnormal ciliary motility (HP:0012262)1.86156455
136Death in childhood (HP:0003819)1.85879906
137Amelogenesis imperfecta (HP:0000705)1.85372682
138Heterotopia (HP:0002282)1.84982141
139Rickets (HP:0002748)1.84875631
140Alacrima (HP:0000522)1.84051550
141* Abnormality of urine glucose concentration (HP:0011016)1.83961944
142* Glycosuria (HP:0003076)1.83961944
143* Abnormality of transition element cation homeostasis (HP:0011030)1.83439096
144Abnormal respiratory epithelium morphology (HP:0012253)1.82489673
145Abnormal respiratory motile cilium morphology (HP:0005938)1.82489673
146Abnormality of the aortic arch (HP:0012303)1.81173103
147Abnormality of the acetabulum (HP:0003170)1.77974714
148Neonatal death (HP:0003811)1.77746773
149Vaginal fistula (HP:0004320)1.77207651
150Renovascular hypertension (HP:0100817)1.76994989
151Limited elbow extension (HP:0001377)1.75934336
152Anal stenosis (HP:0002025)1.71469527
153Abnormality of dental color (HP:0011073)1.70721515
154Abnormal foot bone ossification (HP:0010675)1.67804751
155Hyperkalemia (HP:0002153)1.66694602
156Septate vagina (HP:0001153)1.65768472
157Abnormality of reticulocytes (HP:0004312)1.64802732
158Vitreoretinal degeneration (HP:0000655)1.63947785
159Abnormality of the dental pulp (HP:0006479)1.63169700
160Neonatal short-limb short stature (HP:0008921)1.62400021
161Bifid tongue (HP:0010297)1.60158129
162Nephritis (HP:0000123)1.59707575
163Epiphyseal dysplasia (HP:0002656)1.53158672
164Impulsivity (HP:0100710)1.52799220
165Abnormality of the lacrimal duct (HP:0011481)1.52542499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.26946791
2BCKDK5.10406961
3PLK44.45310669
4SIK13.60586893
5FGFR43.45158502
6CDK123.20811622
7ERN12.99059721
8TRIB32.76835063
9STK38L2.74047764
10WNK42.65539716
11CAMK1G2.57855814
12EEF2K2.48281346
13INSRR2.39298005
14TYRO32.27967271
15DAPK22.21780391
16PNCK2.14033438
17CAMK1D2.10280140
18TAOK32.07648278
19FLT31.94424019
20PRKG21.83786071
21MAP3K31.82489190
22SGK21.80924254
23ERBB41.80223599
24FGFR21.77167344
25STK241.73464756
26MST1R1.72730240
27MAPK151.70131332
28PKN21.66003139
29STK391.65267834
30WNK11.63232128
31NTRK21.55957984
32CASK1.53782604
33AKT31.53122682
34ZAK1.38692701
35SGK31.38319733
36MAPK111.33032998
37MAP2K31.28403286
38LATS21.27490546
39KDR1.25729084
40LATS11.25075117
41FRK1.24199542
42MAP2K41.22651863
43ERBB21.22354829
44GRK11.21635561
45OBSCN1.21318870
46RET1.20013091
47PINK11.18922907
48MAP3K21.16444499
49NME11.12892442
50PDGFRA1.12583161
51STK381.12176903
52MAP3K41.12039411
53PDK21.11516437
54SGK2231.10579983
55SGK4941.10579983
56TGFBR21.07186028
57MAP3K101.06835333
58CDK61.06366484
59NTRK31.03449394
60PRKAA21.03221255
61MAP3K111.02754482
62EIF2AK21.02536623
63DDR21.02042010
64CDK71.00986097
65MAP3K70.98490954
66SRPK10.98476922
67PIK3CG0.97863742
68FGFR30.97853131
69TTK0.97358868
70PLK20.96663097
71RIPK10.91872621
72EPHA30.91453739
73PIK3CA0.91264970
74TIE10.90455694
75TYK20.89965975
76PRKAA10.86621723
77TAOK20.85908804
78PDPK10.85775874
79MYLK0.84827142
80PTK60.82679482
81PRKCZ0.80398430
82EPHA40.79536492
83NUAK10.77686639
84STK100.76484643
85ICK0.76408701
86PBK0.74246431
87BRSK20.73267598
88NEK60.71496788
89ABL20.70215536
90KSR20.68907559
91STK40.67692490
92GSK3A0.67379945
93ACVR1B0.67336372
94JAK20.67111098
95PRKACG0.66198647
96RPS6KB20.64493714
97CDK10.62860107
98SGK10.61523476
99CDK40.59936993
100CSNK1E0.56836037
101CDK20.55654072
102BCR0.55257792
103CHEK10.54766099
104SCYL20.54724063
105GSK3B0.54358334
106ATM0.53920932
107TGFBR10.53417089
108EPHA20.51575288
109CHEK20.51565724
110GRK60.50311985
111AURKA0.49957747
112TNIK0.46508657
113MAPK40.45561524
114MAP2K70.45483620
115PLK10.44722782
116MAP2K60.44001090
117PDK10.43254161
118BRD40.43236976
119MET0.42926834
120MAPKAPK30.42658285
121MTOR0.42466937
122CHUK0.40686969
123MATK0.40177227
124MAP3K60.40093424
125NEK90.39569211
126BMX0.38492124
127ROCK10.37621765
128MKNK10.36543890
129MAPK140.36216138
130STK30.36146425
131WEE10.36014419
132ATR0.35604593
133PRKDC0.35294040
134EIF2AK10.34985621
135MARK10.33937700
136CSNK1G10.31834307
137RPS6KB10.30505154
138AKT20.30083255
139IKBKE0.29441870
140CSNK2A10.29206736
141DYRK1B0.29134301
142PTK20.28072457
143NEK20.27673842
144MAPK120.27182318
145MAP2K10.26953158
146PRKCQ0.26726710
147MAPK30.25653256
148PRKCA0.23674527
149PIM10.22669678
150FGFR10.21408185
151FER0.20590322
152CAMK2G0.19981414
153AURKB0.19855274
154MAP3K80.19373950
155CAMK40.19185963

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.20011196
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28891118
3Nitrogen metabolism_Homo sapiens_hsa009103.18414538
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80210230
5Arginine biosynthesis_Homo sapiens_hsa002202.68981545
6Fatty acid degradation_Homo sapiens_hsa000712.63848167
7Tryptophan metabolism_Homo sapiens_hsa003802.59237111
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58833100
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57380157
10Complement and coagulation cascades_Homo sapiens_hsa046102.54441637
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52630299
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37261560
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30597517
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26062962
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.11112087
16Peroxisome_Homo sapiens_hsa041462.09273911
17Chemical carcinogenesis_Homo sapiens_hsa052042.08901744
18Caffeine metabolism_Homo sapiens_hsa002321.91402176
19Butanoate metabolism_Homo sapiens_hsa006501.90767304
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.90720052
21Propanoate metabolism_Homo sapiens_hsa006401.90606996
22Histidine metabolism_Homo sapiens_hsa003401.88406941
23Selenocompound metabolism_Homo sapiens_hsa004501.83610387
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.82775688
25beta-Alanine metabolism_Homo sapiens_hsa004101.82009988
26Retinol metabolism_Homo sapiens_hsa008301.78340082
27Fatty acid metabolism_Homo sapiens_hsa012121.76351942
28PPAR signaling pathway_Homo sapiens_hsa033201.73728359
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62879496
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57679212
31Phenylalanine metabolism_Homo sapiens_hsa003601.56105900
32Bile secretion_Homo sapiens_hsa049761.54255304
33Tyrosine metabolism_Homo sapiens_hsa003501.52842810
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.52797072
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.48927642
36Sulfur metabolism_Homo sapiens_hsa009201.48707961
37ABC transporters_Homo sapiens_hsa020101.48221814
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48013603
39Pyruvate metabolism_Homo sapiens_hsa006201.45785863
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39675290
41Staphylococcus aureus infection_Homo sapiens_hsa051501.38754779
42Fat digestion and absorption_Homo sapiens_hsa049751.38030896
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35719064
44Biosynthesis of amino acids_Homo sapiens_hsa012301.31249849
45Starch and sucrose metabolism_Homo sapiens_hsa005001.31135307
46Folate biosynthesis_Homo sapiens_hsa007901.30703134
47Fatty acid elongation_Homo sapiens_hsa000621.29993276
48Carbon metabolism_Homo sapiens_hsa012001.26338817
49Sulfur relay system_Homo sapiens_hsa041221.24574081
50One carbon pool by folate_Homo sapiens_hsa006701.20497512
51Vitamin digestion and absorption_Homo sapiens_hsa049771.07551163
52Steroid biosynthesis_Homo sapiens_hsa001001.05097002
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03453562
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.03044494
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02730807
56Arginine and proline metabolism_Homo sapiens_hsa003300.97845877
57Vitamin B6 metabolism_Homo sapiens_hsa007500.95273027
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94286641
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.90883404
60Thyroid hormone synthesis_Homo sapiens_hsa049180.88878691
61Glutathione metabolism_Homo sapiens_hsa004800.87592917
62Lysine degradation_Homo sapiens_hsa003100.87348726
63N-Glycan biosynthesis_Homo sapiens_hsa005100.82662934
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82545789
65Pentose phosphate pathway_Homo sapiens_hsa000300.80454168
66Glycerolipid metabolism_Homo sapiens_hsa005610.79570336
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77833970
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77258210
69ECM-receptor interaction_Homo sapiens_hsa045120.76807132
70Fatty acid biosynthesis_Homo sapiens_hsa000610.75804344
71Protein digestion and absorption_Homo sapiens_hsa049740.58677246
72Metabolic pathways_Homo sapiens_hsa011000.58619754
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55589215
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.52691610
75Galactose metabolism_Homo sapiens_hsa000520.51581201
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49489049
77Adherens junction_Homo sapiens_hsa045200.46487421
78Sphingolipid metabolism_Homo sapiens_hsa006000.44336270
79Other glycan degradation_Homo sapiens_hsa005110.41066881
80Fructose and mannose metabolism_Homo sapiens_hsa000510.38909418
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38442903
82Tight junction_Homo sapiens_hsa045300.37425184
83Taste transduction_Homo sapiens_hsa047420.35321043
84Olfactory transduction_Homo sapiens_hsa047400.34106679
85Hippo signaling pathway_Homo sapiens_hsa043900.31840919
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31788379
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30955283
88Choline metabolism in cancer_Homo sapiens_hsa052310.29249959
89Inositol phosphate metabolism_Homo sapiens_hsa005620.28777504
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26011388
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23442282
92Prion diseases_Homo sapiens_hsa050200.21398271
93Linoleic acid metabolism_Homo sapiens_hsa005910.21329358
94Systemic lupus erythematosus_Homo sapiens_hsa053220.16913135
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.16772758
96Insulin resistance_Homo sapiens_hsa049310.15394696
97Mineral absorption_Homo sapiens_hsa049780.14280804
98Pyrimidine metabolism_Homo sapiens_hsa002400.12290402
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10894061
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.09490029
101AMPK signaling pathway_Homo sapiens_hsa041520.02491742
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1906850
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1820176
104Huntingtons disease_Homo sapiens_hsa05016-0.1801453
105Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1719771
106Insulin signaling pathway_Homo sapiens_hsa04910-0.1701961
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1585396
108Parkinsons disease_Homo sapiens_hsa05012-0.1508990
109Oxidative phosphorylation_Homo sapiens_hsa00190-0.1439472
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1211321
111Bladder cancer_Homo sapiens_hsa05219-0.1118964
112Purine metabolism_Homo sapiens_hsa00230-0.1111619
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0928434
114Phototransduction_Homo sapiens_hsa04744-0.0771923
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0628787
116Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0626675
117Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0441509
118Renin-angiotensin system_Homo sapiens_hsa04614-0.0336070
119Glucagon signaling pathway_Homo sapiens_hsa04922-0.0221212

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