ATP8A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.62322725
2axon ensheathment in central nervous system (GO:0032291)5.62322725
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.57720435
4neuron cell-cell adhesion (GO:0007158)4.52923448
5synaptic vesicle maturation (GO:0016188)4.38027858
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.30511198
7vocalization behavior (GO:0071625)4.26157689
8regulation of ARF protein signal transduction (GO:0032012)4.26013082
9positive regulation of Rap GTPase activity (GO:0032854)4.24345084
10neuronal action potential propagation (GO:0019227)4.23642412
11locomotory exploration behavior (GO:0035641)4.19544514
12presynaptic membrane assembly (GO:0097105)4.18399453
13presynaptic membrane organization (GO:0097090)4.08934639
14synaptic vesicle exocytosis (GO:0016079)4.06675435
15regulation of Rap GTPase activity (GO:0032317)4.01077870
16regulation of synaptic vesicle exocytosis (GO:2000300)4.00997624
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.00291591
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99854838
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88409694
20negative regulation of neurotransmitter transport (GO:0051589)3.85446378
21negative regulation of neurotransmitter secretion (GO:0046929)3.81422025
22sodium ion export (GO:0071436)3.79795691
23glutamate secretion (GO:0014047)3.68144890
24transmission of nerve impulse (GO:0019226)3.66416119
25protein localization to synapse (GO:0035418)3.65531707
26myelination (GO:0042552)3.64449473
27L-amino acid import (GO:0043092)3.62941618
28regulation of glutamate receptor signaling pathway (GO:1900449)3.62484790
29axon ensheathment (GO:0008366)3.62473305
30ensheathment of neurons (GO:0007272)3.62473305
31long-chain fatty acid biosynthetic process (GO:0042759)3.55868280
32glutamate receptor signaling pathway (GO:0007215)3.55274217
33regulation of neuronal synaptic plasticity (GO:0048168)3.44323506
34regulation of synaptic vesicle transport (GO:1902803)3.43195334
35synaptic transmission, glutamatergic (GO:0035249)3.41876665
36adult walking behavior (GO:0007628)3.36933847
37gamma-aminobutyric acid transport (GO:0015812)3.35688974
38dendritic spine morphogenesis (GO:0060997)3.35645687
39establishment of mitochondrion localization (GO:0051654)3.35433810
40neuron-neuron synaptic transmission (GO:0007270)3.34139467
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.32825887
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.29906842
43neuron recognition (GO:0008038)3.29882013
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.24719907
45exploration behavior (GO:0035640)3.24360396
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.24343794
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22877598
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22440215
49regulation of dendritic spine morphogenesis (GO:0061001)3.20306644
50layer formation in cerebral cortex (GO:0021819)3.16437240
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16308047
52potassium ion import (GO:0010107)3.15618077
53nerve growth factor signaling pathway (GO:0038180)3.14780016
54regulation of synapse structural plasticity (GO:0051823)3.10818555
55regulation of postsynaptic membrane potential (GO:0060078)3.08111734
56cerebellar granule cell differentiation (GO:0021707)3.06833604
57neurotransmitter secretion (GO:0007269)3.04776397
58postsynaptic membrane organization (GO:0001941)3.04726742
59neuronal ion channel clustering (GO:0045161)3.04014384
60positive regulation of membrane potential (GO:0045838)3.02039016
61regulation of B cell receptor signaling pathway (GO:0050855)3.01270130
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00474760
63long-term memory (GO:0007616)2.99700719
64neurotransmitter-gated ion channel clustering (GO:0072578)2.99151888
65dendrite morphogenesis (GO:0048813)2.98198294
66regulation of dendritic spine development (GO:0060998)2.96461513
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95868858
68axonal fasciculation (GO:0007413)2.93389252
69neuromuscular process controlling balance (GO:0050885)2.93211020
70B cell receptor signaling pathway (GO:0050853)2.91846395
71cellular potassium ion homeostasis (GO:0030007)2.91755947
72synaptic vesicle endocytosis (GO:0048488)2.91618230
73activation of protein kinase A activity (GO:0034199)2.90304880
74fatty acid elongation (GO:0030497)2.89976676
75glycine transport (GO:0015816)2.89503665
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89419849
77auditory behavior (GO:0031223)2.88715719
78phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87841117
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86786103
80cell differentiation in hindbrain (GO:0021533)2.86157547
81cellular sodium ion homeostasis (GO:0006883)2.85993887
82regulation of synaptic transmission, glutamatergic (GO:0051966)2.84366054
83negative regulation of dendrite morphogenesis (GO:0050774)2.83953926
84regulation of neurotransmitter secretion (GO:0046928)2.83942605
85establishment of nucleus localization (GO:0040023)2.83860374
86negative regulation of inclusion body assembly (GO:0090084)2.83645457
87potassium ion homeostasis (GO:0055075)2.81434705
88membrane hyperpolarization (GO:0060081)2.81001620
89apical protein localization (GO:0045176)2.80996312
90regulation of synaptic plasticity (GO:0048167)2.80050572
91synapse assembly (GO:0007416)2.79416734
92positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.78062406
93neurotransmitter transport (GO:0006836)2.76993213
94membrane depolarization (GO:0051899)2.76722711
95positive regulation of synapse maturation (GO:0090129)2.76099470
96negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.75396337
97long-term synaptic potentiation (GO:0060291)2.74870115
98asymmetric protein localization (GO:0008105)2.74781173
99neuromuscular process controlling posture (GO:0050884)2.74691052
100membrane assembly (GO:0071709)2.73627676
101neurotransmitter uptake (GO:0001504)2.73433831
102response to auditory stimulus (GO:0010996)2.72194651
103oligodendrocyte differentiation (GO:0048709)2.71768429
104synaptic vesicle docking involved in exocytosis (GO:0016081)2.71525745
105negative regulation of protein localization to cell surface (GO:2000009)2.70971280
106negative regulation of cell killing (GO:0031342)2.70840035
107negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70840035
108regulation of neurotransmitter levels (GO:0001505)2.70510669
109regulation of voltage-gated calcium channel activity (GO:1901385)2.69664674
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67763620
111amino acid import (GO:0043090)2.66623996
112positive regulation of dendritic spine development (GO:0060999)2.65908023
113positive regulation of synaptic transmission, GABAergic (GO:0032230)2.65717518
114peptidyl-tyrosine autophosphorylation (GO:0038083)2.65636804
115regulation of neurotransmitter transport (GO:0051588)2.65259725
116mating behavior (GO:0007617)2.64934674
117organelle transport along microtubule (GO:0072384)2.64440238
118regulation of synaptic transmission, GABAergic (GO:0032228)2.63816722
119membrane depolarization during action potential (GO:0086010)2.62958817
120cerebellar Purkinje cell differentiation (GO:0021702)2.62466959
121vesicle transport along microtubule (GO:0047496)2.61930134
122learning (GO:0007612)2.61888478
123regulation of vesicle fusion (GO:0031338)2.61030561
124cell communication by electrical coupling (GO:0010644)2.59617809
125acidic amino acid transport (GO:0015800)2.52029694
126phosphorelay signal transduction system (GO:0000160)2.50496447
127sarcoplasmic reticulum calcium ion transport (GO:0070296)2.47920994
128positive regulation of gamma-delta T cell activation (GO:0046645)2.47230960
129nucleus localization (GO:0051647)2.46968121
130regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.44680776
131peptidyl-threonine phosphorylation (GO:0018107)2.43093228
132positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42743230
133positive regulation of neurotransmitter secretion (GO:0001956)2.42661882
134regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.42357952
135regulation of skeletal muscle cell differentiation (GO:2001014)2.42249717
136regulation of cell communication by electrical coupling (GO:0010649)2.40630135
137positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39692706
138regulation of cardiac muscle cell contraction (GO:0086004)2.38985253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.54050844
2GBX2_23144817_ChIP-Seq_PC3_Human3.64756270
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86467275
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77591461
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72820853
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39900538
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39900538
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38056928
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32688225
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31100818
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27749600
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22773701
13DROSHA_22980978_ChIP-Seq_HELA_Human2.22161086
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21973388
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.16710732
16REST_21632747_ChIP-Seq_MESCs_Mouse2.14781275
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.13705181
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03482363
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03002871
20TAF15_26573619_Chip-Seq_HEK293_Human2.01198288
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.00644303
22AR_21572438_ChIP-Seq_LNCaP_Human2.00110221
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.97339763
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96713249
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.95356127
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93682630
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92799854
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77784232
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76215942
30GATA1_22025678_ChIP-Seq_K562_Human1.73598795
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.69053199
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66151879
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64924590
34RUNX_20019798_ChIP-Seq_JUKART_Human1.62496180
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60185912
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59973831
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58928244
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58921887
39SMAD4_21799915_ChIP-Seq_A2780_Human1.56798638
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53480024
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50845465
42* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49526096
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.45384486
44P300_19829295_ChIP-Seq_ESCs_Human1.43648583
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37603303
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36983250
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34765991
48AHR_22903824_ChIP-Seq_MCF-7_Human1.34136985
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33503794
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33403678
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32688626
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.31929578
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31680886
54* STAT3_23295773_ChIP-Seq_U87_Human1.31658587
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.31372368
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27611393
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25730855
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25015120
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.24013432
60* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23195994
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.22885277
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22216050
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.21837604
64SCL_19346495_ChIP-Seq_HPC-7_Human1.21550411
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21067904
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20764247
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18897764
68* TCF4_23295773_ChIP-Seq_U87_Human1.18573408
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17448413
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17149233
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.16644324
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.16546306
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15605021
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15399111
75AR_25329375_ChIP-Seq_VCAP_Human1.14753516
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14724929
77ER_23166858_ChIP-Seq_MCF-7_Human1.14679881
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13601436
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12652905
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12345574
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10111472
82* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09731392
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09660875
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09660875
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.08590861
86VDR_22108803_ChIP-Seq_LS180_Human1.08041249
87RNF2_27304074_Chip-Seq_NSC_Mouse1.06284457
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.05864153
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05371623
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03991178
91ZNF274_21170338_ChIP-Seq_K562_Hela1.03658684
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03305999
93FUS_26573619_Chip-Seq_HEK293_Human1.03267399
94TP53_16413492_ChIP-PET_HCT116_Human1.02453626
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.01737033
96* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01510673
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00996646
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00736470
99AR_19668381_ChIP-Seq_PC3_Human1.00644002
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00095811
101* RUNX2_22187159_ChIP-Seq_PCA_Human0.98885590
102* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98030361
103PRDM14_20953172_ChIP-Seq_ESCs_Human0.97367264
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97063341
105* E2F1_18555785_Chip-Seq_ESCs_Mouse0.96946474
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.96788940
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96533553
108P53_22387025_ChIP-Seq_ESCs_Mouse0.95390508
109* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94847331
110FLI1_21867929_ChIP-Seq_TH2_Mouse0.94831714
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93353942
112IGF1R_20145208_ChIP-Seq_DFB_Human0.93300239
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92954460
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92673695
115* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91766210
116* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91716020
117GF1_26923725_Chip-Seq_HPCs_Mouse0.90883684
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.89182529
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.88717040
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.88597399
121KDM2B_26808549_Chip-Seq_REH_Human0.86490697
122* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85243023
123* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83682518
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83132425
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82652171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.26867033
2MP0003880_abnormal_central_pattern4.73082720
3MP0004270_analgesia3.90444525
4MP0003635_abnormal_synaptic_transmissio3.59055010
5MP0002064_seizures3.09679245
6MP0009745_abnormal_behavioral_response3.09456133
7MP0009046_muscle_twitch3.03082345
8MP0002063_abnormal_learning/memory/cond2.85480764
9MP0000920_abnormal_myelination2.81950557
10MP0002272_abnormal_nervous_system2.80849586
11MP0001486_abnormal_startle_reflex2.78789076
12MP0001968_abnormal_touch/_nociception2.75073477
13MP0005423_abnormal_somatic_nervous2.57267339
14MP0002572_abnormal_emotion/affect_behav2.57247805
15MP0002734_abnormal_mechanical_nocicepti2.55144542
16MP0002735_abnormal_chemical_nociception2.29543412
17MP0003329_amyloid_beta_deposits2.26081826
18MP0002822_catalepsy2.25831222
19MP0002736_abnormal_nociception_after2.17220377
20MP0001440_abnormal_grooming_behavior2.13945032
21MP0000778_abnormal_nervous_system2.08312543
22MP0002733_abnormal_thermal_nociception2.08189536
23MP0003690_abnormal_glial_cell2.03682138
24MP0001970_abnormal_pain_threshold2.03424217
25MP0004885_abnormal_endolymph2.03204984
26MP0002067_abnormal_sensory_capabilities1.94014311
27MP0008569_lethality_at_weaning1.91839064
28MP0001501_abnormal_sleep_pattern1.85265487
29MP0005386_behavior/neurological_phenoty1.84438876
30MP0004924_abnormal_behavior1.84438876
31MP0004142_abnormal_muscle_tone1.80638325
32MP0001529_abnormal_vocalization1.77259494
33MP0004742_abnormal_vestibular_system1.71795570
34MP0002009_preneoplasia1.70980773
35MP0001905_abnormal_dopamine_level1.69734278
36MP0000955_abnormal_spinal_cord1.68458240
37MP0003634_abnormal_glial_cell1.66503312
38MP0005645_abnormal_hypothalamus_physiol1.64109921
39MP0003633_abnormal_nervous_system1.56122253
40MP0005171_absent_coat_pigmentation1.54152375
41MP0002882_abnormal_neuron_morphology1.53017871
42MP0005409_darkened_coat_color1.52093072
43MP0002557_abnormal_social/conspecific_i1.51846308
44MP0004811_abnormal_neuron_physiology1.49355880
45MP0002184_abnormal_innervation1.48927375
46MP0003303_peritoneal_inflammation1.48823413
47MP0002229_neurodegeneration1.47177205
48MP0002066_abnormal_motor_capabilities/c1.46830585
49MP0009780_abnormal_chondrocyte_physiolo1.42939282
50MP0003631_nervous_system_phenotype1.42041507
51MP0005646_abnormal_pituitary_gland1.41625848
52MP0004130_abnormal_muscle_cell1.35345795
53MP0008057_abnormal_DNA_replication1.31652575
54MP0006276_abnormal_autonomic_nervous1.26148258
55MP0003632_abnormal_nervous_system1.24856381
56MP0004858_abnormal_nervous_system1.23648630
57MP0003787_abnormal_imprinting1.22967504
58MP0001502_abnormal_circadian_rhythm1.22410372
59MP0003763_abnormal_thymus_physiology1.21841229
60MP0004036_abnormal_muscle_relaxation1.19414134
61MP0001177_atelectasis1.19018906
62MP0001188_hyperpigmentation1.14963953
63MP0001485_abnormal_pinna_reflex1.14664341
64MP0000604_amyloidosis1.11476644
65MP0004147_increased_porphyrin_level1.08699860
66MP0004145_abnormal_muscle_electrophysio1.07474973
67MP0002152_abnormal_brain_morphology1.06293440
68MP0005551_abnormal_eye_electrophysiolog1.04360926
69MP0001963_abnormal_hearing_physiology1.02958035
70MP0003950_abnormal_plasma_membrane1.00161203
71MP0002638_abnormal_pupillary_reflex0.98567797
72MP0001984_abnormal_olfaction0.94661225
73MP0004510_myositis0.94619303
74MP0004484_altered_response_of0.93012574
75MP0003172_abnormal_lysosome_physiology0.92903121
76MP0002909_abnormal_adrenal_gland0.92708090
77MP0003075_altered_response_to0.92685162
78MP0002752_abnormal_somatic_nervous0.92274852
79MP0005310_abnormal_salivary_gland0.90668237
80MP0003866_abnormal_defecation0.90583122
81MP0008874_decreased_physiological_sensi0.89340748
82MP0001800_abnormal_humoral_immune0.89203584
83MP0005535_abnormal_body_temperature0.88396646
84MP0001835_abnormal_antigen_presentation0.83505449
85MP0002166_altered_tumor_susceptibility0.78273698
86MP0002332_abnormal_exercise_endurance0.74910534
87MP0003136_yellow_coat_color0.74894218
88MP0005410_abnormal_fertilization0.74846568
89MP0000569_abnormal_digit_pigmentation0.74759407
90MP0003879_abnormal_hair_cell0.74367429
91MP0000747_muscle_weakness0.74212082
92MP0000751_myopathy0.72992638
93MP0000631_abnormal_neuroendocrine_gland0.72474512
94MP0004085_abnormal_heartbeat0.72328974
95MP0001790_abnormal_immune_system0.71959401
96MP0005387_immune_system_phenotype0.71959401
97MP0001943_abnormal_respiration0.71697606
98MP0002069_abnormal_eating/drinking_beha0.69779486
99MP0005058_abnormal_lysosome_morphology0.68584100
100MP0004043_abnormal_pH_regulation0.68505493
101MP0000462_abnormal_digestive_system0.66862012
102MP0000015_abnormal_ear_pigmentation0.66582789
103MP0005167_abnormal_blood-brain_barrier0.66435583
104MP0003137_abnormal_impulse_conducting0.65712069
105MP0001664_abnormal_digestion0.64077133
106MP0003646_muscle_fatigue0.64054051
107MP0003122_maternal_imprinting0.63844553
108MP0001299_abnormal_eye_distance/0.63175095
109MP0005000_abnormal_immune_tolerance0.62793805
110MP0005388_respiratory_system_phenotype0.60784435
111MP0002133_abnormal_respiratory_system0.60784435
112MP0005671_abnormal_response_to0.60697686
113MP0002090_abnormal_vision0.59537553
114MP0010678_abnormal_skin_adnexa0.59293178
115MP0008872_abnormal_physiological_respon0.58754875
116MP0003724_increased_susceptibility_to0.56927775
117MP0002420_abnormal_adaptive_immunity0.56259821
118MP0008877_abnormal_DNA_methylation0.56066197
119MP0003045_fibrosis0.55568348
120MP0000465_gastrointestinal_hemorrhage0.54973156
121MP0000026_abnormal_inner_ear0.54678126
122MP0002398_abnormal_bone_marrow0.54643900
123MP0001765_abnormal_ion_homeostasis0.53254063
124MP0001986_abnormal_taste_sensitivity0.52809660
125MP0005195_abnormal_posterior_eye0.51823982
126MP0010769_abnormal_survival0.50221626
127MP0003183_abnormal_peptide_metabolism0.49962830

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.74154122
2Myokymia (HP:0002411)5.50216496
3Neurofibrillary tangles (HP:0002185)5.33969141
4Supranuclear gaze palsy (HP:0000605)4.63073195
5Focal seizures (HP:0007359)4.49219379
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.37956514
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.37956514
8Cerebral inclusion bodies (HP:0100314)4.19011769
9Action tremor (HP:0002345)4.08568213
10Atonic seizures (HP:0010819)4.03200076
11Epileptic encephalopathy (HP:0200134)4.01056393
12Abnormality of the corticospinal tract (HP:0002492)3.95510480
13Dysmetria (HP:0001310)3.68168893
14Ankle clonus (HP:0011448)3.64049307
15Intention tremor (HP:0002080)3.54216080
16Spastic gait (HP:0002064)3.47222295
17Febrile seizures (HP:0002373)3.44543365
18Progressive cerebellar ataxia (HP:0002073)3.38157589
19Insidious onset (HP:0003587)3.36506189
20Termporal pattern (HP:0011008)3.36506189
21Broad-based gait (HP:0002136)3.27742656
22Visual hallucinations (HP:0002367)3.25904315
23Absence seizures (HP:0002121)3.20376351
24Scanning speech (HP:0002168)3.20336277
25Dialeptic seizures (HP:0011146)3.17638957
26Peripheral hypomyelination (HP:0007182)3.10485508
27Dysdiadochokinesis (HP:0002075)3.03811197
28Gaze-evoked nystagmus (HP:0000640)2.99537238
29Hemiplegia (HP:0002301)2.89607942
30Urinary bladder sphincter dysfunction (HP:0002839)2.87482768
31Difficulty running (HP:0009046)2.87455021
32Generalized tonic-clonic seizures (HP:0002069)2.86586050
33Truncal ataxia (HP:0002078)2.76389909
34Thickened helices (HP:0000391)2.76298909
35Onion bulb formation (HP:0003383)2.73902163
36Postural instability (HP:0002172)2.73243143
37Dysmetric saccades (HP:0000641)2.70687787
38Akinesia (HP:0002304)2.68892715
39Urinary urgency (HP:0000012)2.68256541
40Lower limb muscle weakness (HP:0007340)2.67953231
41Sensory axonal neuropathy (HP:0003390)2.67831429
42Mutism (HP:0002300)2.65752773
43Hyperventilation (HP:0002883)2.63368923
44Clumsiness (HP:0002312)2.63347555
45Anxiety (HP:0000739)2.62455545
46Poor eye contact (HP:0000817)2.60064317
47Depression (HP:0000716)2.51746512
48Progressive inability to walk (HP:0002505)2.51238259
49Megalencephaly (HP:0001355)2.49219762
50Pheochromocytoma (HP:0002666)2.49054355
51Bundle branch block (HP:0011710)2.48760214
52Impaired vibration sensation in the lower limbs (HP:0002166)2.40800807
53Alacrima (HP:0000522)2.40580038
54Drooling (HP:0002307)2.34161097
55Excessive salivation (HP:0003781)2.34161097
56Impaired social interactions (HP:0000735)2.30885830
57Abnormal social behavior (HP:0012433)2.30885830
58Colitis (HP:0002583)2.29884024
59Neuronal loss in central nervous system (HP:0002529)2.27468034
60Agammaglobulinemia (HP:0004432)2.23346992
61Muscle fiber inclusion bodies (HP:0100299)2.22287618
62Hemiparesis (HP:0001269)2.22212652
63Exercise-induced myalgia (HP:0003738)2.22069138
64Abnormality of binocular vision (HP:0011514)2.21360937
65Diplopia (HP:0000651)2.21360937
66Amyotrophic lateral sclerosis (HP:0007354)2.21317602
67Abnormal eating behavior (HP:0100738)2.21096032
68Papillary thyroid carcinoma (HP:0002895)2.19776538
69Retinal dysplasia (HP:0007973)2.18682297
70Papilledema (HP:0001085)2.18462316
71Abnormality of the left ventricular outflow tract (HP:0011103)2.18359453
72Subaortic stenosis (HP:0001682)2.18359453
73Bowel incontinence (HP:0002607)2.16928708
74Absent speech (HP:0001344)2.13494141
75Widely spaced teeth (HP:0000687)2.12824548
76Obstructive sleep apnea (HP:0002870)2.12328589
77Impaired smooth pursuit (HP:0007772)2.11395517
78Neuroendocrine neoplasm (HP:0100634)2.10490451
79Aplasia involving bones of the upper limbs (HP:0009823)2.10192944
80Aplasia of the phalanges of the hand (HP:0009802)2.10192944
81Aplasia involving bones of the extremities (HP:0009825)2.10192944
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09913984
83Generalized myoclonic seizures (HP:0002123)2.09606806
84Clonus (HP:0002169)2.09527424
85Slow saccadic eye movements (HP:0000514)2.08392428
86Hyporeflexia of lower limbs (HP:0002600)2.07682742
87Nemaline bodies (HP:0003798)2.07513332
88Anteriorly placed anus (HP:0001545)2.06436702
89Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.06016988
90Abnormality of ocular smooth pursuit (HP:0000617)2.00600860
91Decreased lacrimation (HP:0000633)2.00545260
92Psychosis (HP:0000709)1.99250963
93Abnormality of the fingertips (HP:0001211)1.99106928
94Abnormal large intestine physiology (HP:0012700)1.98834713
95Abnormal auditory evoked potentials (HP:0006958)1.98695658
96Aqueductal stenosis (HP:0002410)1.97645005
97Bradykinesia (HP:0002067)1.97276098
98Gastrointestinal stroma tumor (HP:0100723)1.97211933
99Muscle hypertrophy of the lower extremities (HP:0008968)1.96567339
100Spastic paraplegia (HP:0001258)1.96394261
101Frequent falls (HP:0002359)1.94858790
102EMG: neuropathic changes (HP:0003445)1.94585338
103Status epilepticus (HP:0002133)1.93437570
104Increased circulating renin level (HP:0000848)1.91639600
105Amblyopia (HP:0000646)1.90856354
106Morphological abnormality of the pyramidal tract (HP:0002062)1.90103016
107Blue irides (HP:0000635)1.89444933
108Calf muscle hypertrophy (HP:0008981)1.87379118
109Abnormality of saccadic eye movements (HP:0000570)1.87342027
110Paraplegia (HP:0010550)1.87069893
111Genetic anticipation (HP:0003743)1.87033842
112Abnormality of the periventricular white matter (HP:0002518)1.86873745
113Decreased motor nerve conduction velocity (HP:0003431)1.86669112
114Abnormal hair whorl (HP:0010721)1.84536759
115Spastic tetraparesis (HP:0001285)1.84318796
116Abnormality of salivation (HP:0100755)1.83172025
117Fetal akinesia sequence (HP:0001989)1.82173426
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82141989
119Rapidly progressive (HP:0003678)1.82076197
120T lymphocytopenia (HP:0005403)1.81363163
121Gait ataxia (HP:0002066)1.81018387
122Inability to walk (HP:0002540)1.80947638
123Tetraplegia (HP:0002445)1.80888538
124Limb dystonia (HP:0002451)1.80389245
125Recurrent sinusitis (HP:0011108)1.79013549
126Postural tremor (HP:0002174)1.77106089
127Macroorchidism (HP:0000053)1.76178779
128Stereotypic behavior (HP:0000733)1.75916744
129Impaired vibratory sensation (HP:0002495)1.75711432
130Menstrual irregularities (HP:0000858)1.74412739
131Epileptiform EEG discharges (HP:0011182)1.74268574
132Rigidity (HP:0002063)1.74199132
133Cerebral hemorrhage (HP:0001342)1.74064777
134Gait imbalance (HP:0002141)1.73798282
135Incomplete penetrance (HP:0003829)1.72739430
136Ventricular fibrillation (HP:0001663)1.72439388
137Hyperkalemia (HP:0002153)1.72425930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.48137648
2NTRK33.33328160
3STK393.08259495
4MAP3K92.74756634
5OXSR12.68401574
6MARK12.59745546
7PRPF4B2.25321192
8CASK2.23317693
9NTRK12.21212904
10OBSCN2.13559736
11TNIK2.03288565
12DAPK21.99092267
13CDK191.98800739
14PAK61.81142217
15NTRK21.79111339
16PNCK1.75003084
17MAP3K41.71939166
18MINK11.70279524
19UHMK11.67438534
20KSR21.61526483
21RIPK41.60499579
22FGFR21.47327943
23WNK11.47164556
24SGK2231.45606847
25SGK4941.45606847
26CDK51.45504039
27MAP2K71.42931150
28MAPK121.41287240
29FGR1.41259058
30PKN11.37421127
31ICK1.32609431
32CAMK2B1.31834576
33PHKG21.31510412
34PHKG11.31510412
35PRKD31.31504100
36FGFR31.30981331
37MAPK131.26274090
38EPHB11.25747377
39JAK11.22945265
40FES1.20378545
41BCR1.19330247
42MAPKAPK51.18743775
43TYRO31.17373542
44MAP3K131.15251180
45SYK1.15102037
46CSNK1G21.13952836
47CAMK2A1.11286731
48MAP4K11.09680302
49NEK61.06811629
50ARAF0.99789669
51PRKCH0.97581293
52MAP3K20.97327421
53AKT30.96886393
54CAMK40.96356132
55WNK40.94487697
56CSNK1G30.94351021
57BRD40.93490896
58CSNK1A1L0.92230585
59MARK20.91899280
60MAP3K70.89886266
61GRK50.86981115
62CAMK2D0.86831283
63MAP3K120.85704063
64CAMK1G0.85386768
65CAMKK10.85282283
66PLK20.84679733
67JAK20.82804794
68ROCK20.82591380
69MAP2K40.81036481
70KSR10.80844471
71LIMK10.80632731
72PINK10.80111605
73MAPK70.79448763
74CAMK2G0.78199852
75DAPK10.76472225
76MAPK150.75813776
77CAMKK20.75124429
78CDK140.74708125
79PRKCE0.74433036
80RIPK10.73734498
81PDPK10.73627934
82SGK20.72549085
83BTK0.72508375
84LMTK20.71278752
85STK110.70808194
86CDK150.69896329
87CDK180.69290654
88SGK10.69216086
89MET0.68666094
90CSNK1G10.67865140
91BLK0.67297625
92BMPR20.66998348
93ITK0.65871044
94PRKCG0.65588401
95PAK30.65176139
96FYN0.64531840
97MAP3K10.63153283
98RPS6KA30.63100133
99IKBKE0.62440495
100MUSK0.62379738
101CAMK10.61034448
102SGK30.60768505
103PDK10.60622088
104PRKCQ0.59168129
105CDK11A0.58950427
106SIK20.58304786
107GRK70.57242939
108HCK0.56711626
109FRK0.56454948
110MAP3K140.56010619
111TEC0.55919006
112RET0.54860768
113RAF10.53152079
114PTK2B0.51697885
115PRKCZ0.51212126
116TAOK30.51067450
117TNK20.49100783
118CLK10.48404043
119PRKD10.47615145
120CCNB10.47060493
121MAP3K60.46866177
122MAPK100.46673673
123NLK0.46517039
124MAP3K100.46196382
125HIPK20.44968631
126MAPK40.44856166
127RPS6KB10.44855412
128DYRK1A0.44684330
129DMPK0.44341828
130ALK0.42677879
131PRKG10.42576778
132CSF1R0.41642212
133YES10.41029426
134PIK3CG0.38589414
135STK380.37964965

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.05476818
2Synaptic vesicle cycle_Homo sapiens_hsa047212.52241408
3GABAergic synapse_Homo sapiens_hsa047272.48825963
4Glutamatergic synapse_Homo sapiens_hsa047242.43001023
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40877986
6Morphine addiction_Homo sapiens_hsa050322.38160324
7Circadian entrainment_Homo sapiens_hsa047132.31477560
8Olfactory transduction_Homo sapiens_hsa047402.23510559
9Long-term potentiation_Homo sapiens_hsa047202.10762940
10Salivary secretion_Homo sapiens_hsa049701.99762946
11Amphetamine addiction_Homo sapiens_hsa050311.94172946
12Dopaminergic synapse_Homo sapiens_hsa047281.85365667
13Serotonergic synapse_Homo sapiens_hsa047261.84025518
14Long-term depression_Homo sapiens_hsa047301.80358451
15Gastric acid secretion_Homo sapiens_hsa049711.75178126
16Cholinergic synapse_Homo sapiens_hsa047251.70546731
17Taste transduction_Homo sapiens_hsa047421.67781127
18Renin secretion_Homo sapiens_hsa049241.60536853
19B cell receptor signaling pathway_Homo sapiens_hsa046621.56932400
20Cocaine addiction_Homo sapiens_hsa050301.56719908
21Axon guidance_Homo sapiens_hsa043601.55245147
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54854241
23Insulin secretion_Homo sapiens_hsa049111.52218812
24Collecting duct acid secretion_Homo sapiens_hsa049661.44064033
25Oxytocin signaling pathway_Homo sapiens_hsa049211.39644231
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39558112
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38167351
28Calcium signaling pathway_Homo sapiens_hsa040201.34540084
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33135634
30Ether lipid metabolism_Homo sapiens_hsa005651.31358190
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28623190
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28184624
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27900702
34Dorso-ventral axis formation_Homo sapiens_hsa043201.27728962
35GnRH signaling pathway_Homo sapiens_hsa049121.24474715
36Gap junction_Homo sapiens_hsa045401.23881491
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23126013
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19409312
39ErbB signaling pathway_Homo sapiens_hsa040121.17204755
40cAMP signaling pathway_Homo sapiens_hsa040241.16688178
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14344030
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13889843
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06331279
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.05583160
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05488389
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.04982144
47T cell receptor signaling pathway_Homo sapiens_hsa046601.01559124
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99459675
49Vibrio cholerae infection_Homo sapiens_hsa051100.98011467
50Estrogen signaling pathway_Homo sapiens_hsa049150.96479539
51Steroid biosynthesis_Homo sapiens_hsa001000.95355232
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.94803223
53Non-small cell lung cancer_Homo sapiens_hsa052230.93502600
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92985556
55Endometrial cancer_Homo sapiens_hsa052130.92560765
56Pancreatic secretion_Homo sapiens_hsa049720.91227232
57mTOR signaling pathway_Homo sapiens_hsa041500.89825194
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89648563
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89104846
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87928913
61Choline metabolism in cancer_Homo sapiens_hsa052310.87352343
62Fatty acid elongation_Homo sapiens_hsa000620.86760568
63Melanogenesis_Homo sapiens_hsa049160.86223830
64Renal cell carcinoma_Homo sapiens_hsa052110.84658468
65Circadian rhythm_Homo sapiens_hsa047100.83798503
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83397816
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83181057
68Endocytosis_Homo sapiens_hsa041440.81529079
69Type II diabetes mellitus_Homo sapiens_hsa049300.81149620
70Type I diabetes mellitus_Homo sapiens_hsa049400.80893693
71MAPK signaling pathway_Homo sapiens_hsa040100.80891471
72Prolactin signaling pathway_Homo sapiens_hsa049170.80743203
73Ras signaling pathway_Homo sapiens_hsa040140.80018426
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80007341
75Glioma_Homo sapiens_hsa052140.79816100
76Autoimmune thyroid disease_Homo sapiens_hsa053200.79209375
77Cardiac muscle contraction_Homo sapiens_hsa042600.77731846
78Phototransduction_Homo sapiens_hsa047440.77227239
79Sphingolipid metabolism_Homo sapiens_hsa006000.75935765
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74710235
81Osteoclast differentiation_Homo sapiens_hsa043800.72496790
82Bile secretion_Homo sapiens_hsa049760.71680022
83Allograft rejection_Homo sapiens_hsa053300.68821152
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67271301
85Primary immunodeficiency_Homo sapiens_hsa053400.67170476
86Graft-versus-host disease_Homo sapiens_hsa053320.66769288
87Fatty acid biosynthesis_Homo sapiens_hsa000610.65242020
88Rap1 signaling pathway_Homo sapiens_hsa040150.65160648
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64816485
90Dilated cardiomyopathy_Homo sapiens_hsa054140.64511301
91Insulin signaling pathway_Homo sapiens_hsa049100.64074065
92Glucagon signaling pathway_Homo sapiens_hsa049220.63979383
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63029354
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62968590
95Tight junction_Homo sapiens_hsa045300.61909450
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61341821
97Thyroid hormone synthesis_Homo sapiens_hsa049180.60738514
98Colorectal cancer_Homo sapiens_hsa052100.60433305
99VEGF signaling pathway_Homo sapiens_hsa043700.60173164
100Chemokine signaling pathway_Homo sapiens_hsa040620.59467274
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.59295254
102Inositol phosphate metabolism_Homo sapiens_hsa005620.59194702
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59143931
104FoxO signaling pathway_Homo sapiens_hsa040680.59032000
105Leishmaniasis_Homo sapiens_hsa051400.58901133
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58515881
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58439724
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57203229
109Tuberculosis_Homo sapiens_hsa051520.55412154
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55410478
111Mineral absorption_Homo sapiens_hsa049780.54590185
112Ovarian steroidogenesis_Homo sapiens_hsa049130.54448884
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.52410854
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.51926280
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51727263
116Acute myeloid leukemia_Homo sapiens_hsa052210.51305509
117Rheumatoid arthritis_Homo sapiens_hsa053230.50604813
118Oocyte meiosis_Homo sapiens_hsa041140.50210533
119Alzheimers disease_Homo sapiens_hsa050100.49227412
120ABC transporters_Homo sapiens_hsa020100.48217608
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.47743978
122Alcoholism_Homo sapiens_hsa050340.47344995
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47082045
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46179637
125Chronic myeloid leukemia_Homo sapiens_hsa052200.45252126
126Insulin resistance_Homo sapiens_hsa049310.44538859
127Wnt signaling pathway_Homo sapiens_hsa043100.44124748
128Phagosome_Homo sapiens_hsa041450.43766068
129Pancreatic cancer_Homo sapiens_hsa052120.43181435
130Lysosome_Homo sapiens_hsa041420.43060970
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42614736
132Platelet activation_Homo sapiens_hsa046110.39491871
133Prion diseases_Homo sapiens_hsa050200.38492080
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38451748
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38063601
136African trypanosomiasis_Homo sapiens_hsa051430.37818647

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