ATP8A2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)6.67365583
2regulation of ruffle assembly (GO:1900027)6.41956138
3regulation of hydrogen peroxide metabolic process (GO:0010310)6.37032437
4dermatan sulfate metabolic process (GO:0030205)6.23336959
5positive regulation of protein kinase C signaling (GO:0090037)5.84078673
6chondroitin sulfate catabolic process (GO:0030207)5.57409337
7semaphorin-plexin signaling pathway (GO:0071526)5.55128335
8response to manganese ion (GO:0010042)5.28372368
9face development (GO:0060324)5.15572371
10negative regulation of cell size (GO:0045792)5.15096323
11quaternary ammonium group transport (GO:0015697)5.03683081
12insulin-like growth factor receptor signaling pathway (GO:0048009)4.94284979
13negative regulation of osteoblast proliferation (GO:0033689)4.88077475
14regulation of ARF GTPase activity (GO:0032312)4.76190145
15histone H3-K9 demethylation (GO:0033169)4.74244231
16response to magnesium ion (GO:0032026)4.70599046
17mannose metabolic process (GO:0006013)4.38237469
18ear development (GO:0043583)4.24433449
19endothelial cell chemotaxis (GO:0035767)4.19462842
20positive regulation of histone deacetylation (GO:0031065)4.17972430
21regulation of histone H3-K27 methylation (GO:0061085)4.14300693
22diacylglycerol metabolic process (GO:0046339)4.10733403
23vascular endothelial growth factor signaling pathway (GO:0038084)3.88791872
24facial nerve structural organization (GO:0021612)3.85040441
25peptidyl-tyrosine autophosphorylation (GO:0038083)3.84722706
26negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.79916426
27atrioventricular valve morphogenesis (GO:0003181)3.74557833
28regulation of protein polyubiquitination (GO:1902914)3.71041769
29regulation of respiratory burst (GO:0060263)3.65990072
30CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.62569255
31Rho protein signal transduction (GO:0007266)3.53880134
32regulation of clathrin-mediated endocytosis (GO:2000369)3.52696687
33white fat cell differentiation (GO:0050872)3.50029904
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.46433078
35melanocyte differentiation (GO:0030318)3.36566051
36cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.34341267
37actin filament bundle assembly (GO:0051017)3.30357412
38actin filament bundle organization (GO:0061572)3.30357412
39definitive hemopoiesis (GO:0060216)3.22740762
40positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.21135077
412-oxoglutarate metabolic process (GO:0006103)3.18970461
42phosphatidylinositol 3-kinase signaling (GO:0014065)3.17593101
43lytic vacuole organization (GO:0080171)3.16876032
44lysosome organization (GO:0007040)3.16876032
45negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.16874653
46histone H4 deacetylation (GO:0070933)3.16283595
47regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.14922739
48positive regulation of protein deacetylation (GO:0090312)3.09952647
49regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.08598662
50negative regulation of axon extension involved in axon guidance (GO:0048843)3.08316632
51interferon-gamma secretion (GO:0072643)3.08082893
52regulation of triglyceride catabolic process (GO:0010896)3.07930216
53histone H3 deacetylation (GO:0070932)3.06549397
54pigment cell differentiation (GO:0050931)3.05691325
55cranial nerve morphogenesis (GO:0021602)3.04541814
56regulation of protein kinase C signaling (GO:0090036)3.04095112
57sulfur compound catabolic process (GO:0044273)3.00508593
58dendritic cell chemotaxis (GO:0002407)2.99802573
59Arp2/3 complex-mediated actin nucleation (GO:0034314)2.99541033
60regulation of apoptotic cell clearance (GO:2000425)2.97752237
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93705896
62regulation of histone deacetylation (GO:0031063)2.89175063
63regulation of Rho protein signal transduction (GO:0035023)2.88987401
64positive regulation of macroautophagy (GO:0016239)2.87909156
65negative regulation of transcription by competitive promoter binding (GO:0010944)2.87045550
66endocrine hormone secretion (GO:0060986)2.83442734
67phospholipid scrambling (GO:0017121)2.82251543
68melanosome localization (GO:0032400)2.79781296
69activation of JUN kinase activity (GO:0007257)2.77953111
70regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.76667031
71phosphatidylglycerol biosynthetic process (GO:0006655)2.75367875
72regulation of sequestering of triglyceride (GO:0010889)2.71386002
73pigment granule localization (GO:0051875)2.69269613
74cardiac right ventricle morphogenesis (GO:0003215)2.68790747
75urinary tract smooth muscle contraction (GO:0014848)2.68349600
76regulation of T cell cytokine production (GO:0002724)2.66073450
77glycerophospholipid catabolic process (GO:0046475)2.65013002
78histone H3-K4 trimethylation (GO:0080182)2.64748321
79cranial nerve structural organization (GO:0021604)2.64627136
80lymph vessel development (GO:0001945)2.64555185
81negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64049722
82negative regulation of protein tyrosine kinase activity (GO:0061099)2.63588524
83cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.59218902
84Rap protein signal transduction (GO:0032486)2.58828694
85COPI coating of Golgi vesicle (GO:0048205)2.57896745
86Golgi transport vesicle coating (GO:0048200)2.57896745
87phosphatidylethanolamine biosynthetic process (GO:0006646)2.57131411
88negative regulation of interleukin-2 production (GO:0032703)2.57026451
89regulation of synapse maturation (GO:0090128)2.55393204
90positive regulation of bone remodeling (GO:0046852)2.54880313
91positive regulation of bone resorption (GO:0045780)2.54880313
92cell migration in hindbrain (GO:0021535)2.54388161
93glomerular filtration (GO:0003094)2.54261937
94glycosaminoglycan catabolic process (GO:0006027)2.53362565
95activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.52507101
96cAMP biosynthetic process (GO:0006171)2.52395386
97regulation of interleukin-13 production (GO:0032656)2.50650367
98retrograde transport, endosome to Golgi (GO:0042147)2.49261491
99regulation of establishment or maintenance of cell polarity (GO:0032878)2.48856259
100protein heterotrimerization (GO:0070208)2.48633622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human6.06766897
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.62549206
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.73714478
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.69692277
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.57429977
6DROSHA_22980978_ChIP-Seq_HELA_Human3.25211595
7RUNX1_27514584_Chip-Seq_MCF-7_Human2.61541798
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.55783623
9LXR_22292898_ChIP-Seq_THP-1_Human2.55525863
10RACK7_27058665_Chip-Seq_MCF-7_Human2.47253998
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.44899397
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42516610
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.40604310
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.35480016
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31863130
16KDM2B_26808549_Chip-Seq_DND41_Human2.30486056
17P68_20966046_ChIP-Seq_HELA_Human2.22057921
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17260543
19CTCF_27219007_Chip-Seq_Bcells_Human2.15466985
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.12413410
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09817795
22ZNF263_19887448_ChIP-Seq_K562_Human2.05558052
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92763733
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88377030
25TCF7_22412390_ChIP-Seq_EML_Mouse1.86014032
26KDM2B_26808549_Chip-Seq_K562_Human1.84927161
27CREB1_26743006_Chip-Seq_LNCaP_Human1.80005186
28SMC4_20622854_ChIP-Seq_HELA_Human1.79666312
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77890737
30EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72314344
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64672610
32SA1_27219007_Chip-Seq_ERYTHROID_Human1.60220989
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59459221
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59323769
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54307102
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.52127325
37AHR_22903824_ChIP-Seq_MCF-7_Human1.50516993
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49693791
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.48270409
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.42911757
41TP63_22573176_ChIP-Seq_HFKS_Human1.39713886
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38670009
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37603867
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.32228178
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29942619
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28938886
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28278859
48BCL6_27268052_Chip-Seq_Bcells_Human1.27726077
49E2F1_20622854_ChIP-Seq_HELA_Human1.27041516
50BCOR_27268052_Chip-Seq_Bcells_Human1.26853610
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26329350
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.23964879
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.22609778
54VDR_21846776_ChIP-Seq_THP-1_Human1.22594578
55MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22421536
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20207390
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19635201
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.19543708
59KLF5_25053715_ChIP-Seq_YYC3_Human1.19207272
60TET1_21490601_ChIP-Seq_MESCs_Mouse1.19016208
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.18929072
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17773056
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17516906
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15813349
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13373259
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12690804
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12463989
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11073631
69RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10433878
70MAF_26560356_Chip-Seq_TH2_Human1.08867635
71MYC_27129775_Chip-Seq_CORNEA_Mouse1.08094307
72RARB_24833708_ChIP-Seq_LIVER_Mouse1.07982769
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.07719499
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06387365
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06234303
76PHF8_20622854_ChIP-Seq_HELA_Human1.03967059
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03331903
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01950890
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99873945
80CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98692805
81NCOR1_26117541_ChIP-Seq_K562_Human0.98469168
82OCT4_19829295_ChIP-Seq_ESCs_Human0.97902486
83SA1_27219007_Chip-Seq_Bcells_Human0.97635368
84SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95873869
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95162054
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93937335
87CTCF_26484167_Chip-Seq_Bcells_Mouse0.93264489
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93067108
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91787126
90KLF4_19829295_ChIP-Seq_ESCs_Human0.89042009
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.88294026
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87936957
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87638907
94RUNX1_22412390_ChIP-Seq_EML_Mouse0.87457075
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87307487
96ERA_21632823_ChIP-Seq_H3396_Human0.86703043
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86670385
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86407939
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85645909
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84824021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009384_cardiac_valve_regurgitation5.69007054
2MP0001849_ear_inflammation4.83113969
3MP0003172_abnormal_lysosome_physiology4.21278719
4MP0005083_abnormal_biliary_tract4.12569407
5MP0005058_abnormal_lysosome_morphology4.07974461
6MP0004084_abnormal_cardiac_muscle3.71725750
7MP0004381_abnormal_hair_follicle3.15429111
8MP0002249_abnormal_larynx_morphology3.06789947
9MP0005503_abnormal_tendon_morphology3.02809534
10MP0000013_abnormal_adipose_tissue2.78157813
11MP0008260_abnormal_autophagy2.66267446
12MP0002822_catalepsy2.66221389
13MP0003705_abnormal_hypodermis_morpholog2.51413590
14MP0005275_abnormal_skin_tensile2.49422407
15MP0001958_emphysema2.48615273
16MP0006138_congestive_heart_failure2.47816626
17MP0008438_abnormal_cutaneous_collagen2.40909994
18MP0000767_abnormal_smooth_muscle2.27374571
19MP0001348_abnormal_lacrimal_gland2.24991296
20MP0003279_aneurysm2.15010628
21MP0001299_abnormal_eye_distance/2.10732870
22MP0001502_abnormal_circadian_rhythm2.00097094
23MP0005670_abnormal_white_adipose1.99716935
24MP0004036_abnormal_muscle_relaxation1.98938132
25MP0002933_joint_inflammation1.98022553
26MP0000751_myopathy1.87359749
27MP0002932_abnormal_joint_morphology1.85048876
28MP0005377_hearing/vestibular/ear_phenot1.79925132
29MP0003878_abnormal_ear_physiology1.79925132
30MP0000371_diluted_coat_color1.78748734
31MP0005360_urolithiasis1.75776275
32MP0000003_abnormal_adipose_tissue1.72904859
33MP0009780_abnormal_chondrocyte_physiolo1.62582758
34MP0000678_abnormal_parathyroid_gland1.59688585
35MP0000733_abnormal_muscle_development1.56447628
36MP0010368_abnormal_lymphatic_system1.50817681
37MP0005409_darkened_coat_color1.36311020
38MP0002108_abnormal_muscle_morphology1.30761661
39MP0003879_abnormal_hair_cell1.27033227
40MP0001764_abnormal_homeostasis1.26092443
41MP0003136_yellow_coat_color1.23765613
42MP0005375_adipose_tissue_phenotype1.21961519
43MP0003183_abnormal_peptide_metabolism1.19428734
44MP0003690_abnormal_glial_cell1.17929488
45MP0002060_abnormal_skin_morphology1.11301873
46MP0002796_impaired_skin_barrier1.10318878
47MP0002282_abnormal_trachea_morphology1.07064506
48MP0000681_abnormal_thyroid_gland1.03356861
49MP0003045_fibrosis1.02965463
50MP0000383_abnormal_hair_follicle1.00479030
51MP0002653_abnormal_ependyma_morphology0.97703874
52MP0003137_abnormal_impulse_conducting0.97654889
53MP0000163_abnormal_cartilage_morphology0.96167349
54MP0005410_abnormal_fertilization0.93936159
55MP0001873_stomach_inflammation0.93784450
56MP0002116_abnormal_craniofacial_bone0.87600973
57MP0003942_abnormal_urinary_system0.86143432
58MP0005508_abnormal_skeleton_morphology0.85872541
59MP0001879_abnormal_lymphatic_vessel0.83270674
60MP0002132_abnormal_respiratory_system0.82900824
61MP0004264_abnormal_extraembryonic_tissu0.81877594
62MP0005535_abnormal_body_temperature0.80028893
63MP0000026_abnormal_inner_ear0.78480774
64MP0005666_abnormal_adipose_tissue0.77562068
65MP0005076_abnormal_cell_differentiation0.77540691
66MP0002970_abnormal_white_adipose0.76263857
67MP0005075_abnormal_melanosome_morpholog0.75794956
68MP0010030_abnormal_orbit_morphology0.73219699
69MP0000428_abnormal_craniofacial_morphol0.71561538
70MP0002166_altered_tumor_susceptibility0.71008447
71MP0002896_abnormal_bone_mineralization0.70042760
72MP0003938_abnormal_ear_development0.68695312
73MP0004043_abnormal_pH_regulation0.65438384
74MP0002115_abnormal_skeleton_extremities0.64400956
75MP0005501_abnormal_skin_physiology0.63582248
76MP0002177_abnormal_outer_ear0.63524419
77MP0001765_abnormal_ion_homeostasis0.63374142
78MP0002998_abnormal_bone_remodeling0.62814934
79MP0000427_abnormal_hair_cycle0.62087240
80MP0000230_abnormal_systemic_arterial0.61686934
81MP0002254_reproductive_system_inflammat0.61361909
82MP0001664_abnormal_digestion0.60565901
83MP0000627_abnormal_mammary_gland0.58507962
84MP0008004_abnormal_stomach_pH0.58253678
85MP0000249_abnormal_blood_vessel0.57998044
86MP0002075_abnormal_coat/hair_pigmentati0.57717052
87MP0002114_abnormal_axial_skeleton0.56937246
88MP0003795_abnormal_bone_structure0.56356429
89MP0002113_abnormal_skeleton_development0.55197576
90MP0001614_abnormal_blood_vessel0.54758315
91MP0002128_abnormal_blood_circulation0.54668276
92MP0003724_increased_susceptibility_to0.53391696
93MP0003091_abnormal_cell_migration0.53065844
94MP0005023_abnormal_wound_healing0.52597235
95MP0009643_abnormal_urine_homeostasis0.51679118
96MP0010771_integument_phenotype0.51619643
97MP0001243_abnormal_dermal_layer0.51466126
98MP0000538_abnormal_urinary_bladder0.49704511
99MP0000566_synostosis0.49300694
100MP0002127_abnormal_cardiovascular_syste0.49127551

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)8.69823857
2Cervical subluxation (HP:0003308)7.98487488
3Obstructive sleep apnea (HP:0002870)7.29370378
4Broad face (HP:0000283)7.25791571
5Aortic regurgitation (HP:0001659)6.69467321
6Abnormality of lateral ventricle (HP:0030047)5.35190777
7Deformed sella turcica (HP:0002681)4.92137583
8Stridor (HP:0010307)4.91752418
9Biconcave vertebral bodies (HP:0004586)4.85974261
10Lymphangioma (HP:0100764)4.28537536
11Delayed CNS myelination (HP:0002188)4.14717508
12Vitreoretinal degeneration (HP:0000655)4.03229645
13Flared iliac wings (HP:0002869)4.02961094
14Neurodegeneration (HP:0002180)3.86061207
15Neoplasm of the heart (HP:0100544)3.78717931
16Joint stiffness (HP:0001387)3.74570080
17Nuclear cataract (HP:0100018)3.73838286
18Ependymoma (HP:0002888)3.73783927
19Mucopolysacchariduria (HP:0008155)3.72977977
20Urinary glycosaminoglycan excretion (HP:0003541)3.72977977
21Aortic valve stenosis (HP:0001650)3.69155769
22Dysostosis multiplex (HP:0000943)3.65236341
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.59568576
24Abnormality of polysaccharide metabolism (HP:0011012)3.59568576
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.59568576
26Cerebral palsy (HP:0100021)3.52112944
27Severe Myopia (HP:0011003)3.50501310
28Hypoplasia of the odontoid process (HP:0003311)3.37895169
29Spinal canal stenosis (HP:0003416)3.35944036
30Abnormality of the sella turcica (HP:0002679)3.32476156
31Sleep apnea (HP:0010535)3.28837664
32Tubulointerstitial nephritis (HP:0001970)3.19464908
33Mitral regurgitation (HP:0001653)3.17001495
34Generalized hypopigmentation of hair (HP:0011358)3.15367078
35Thin bony cortex (HP:0002753)3.09823360
36Bundle branch block (HP:0011710)3.01535055
37Abnormality of the femoral head (HP:0003368)2.92091735
38Short clavicles (HP:0000894)2.89628831
39Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.89337053
40Abnormality of the odontoid process (HP:0003310)2.80694194
41Broad metatarsal (HP:0001783)2.76455190
42Astrocytoma (HP:0009592)2.71503296
43Abnormality of the astrocytes (HP:0100707)2.71503296
44Tracheal stenosis (HP:0002777)2.68118434
45Flattened epiphyses (HP:0003071)2.64962700
46Ocular albinism (HP:0001107)2.62220979
47Cerebral aneurysm (HP:0004944)2.61657381
48Metaphyseal cupping (HP:0003021)2.58926721
49Easy fatigability (HP:0003388)2.56399883
50Mild short stature (HP:0003502)2.56168673
51Aplasia/Hypoplasia of the clavicles (HP:0006710)2.53685022
52Hypoplastic ischia (HP:0003175)2.50058437
53Visceral angiomatosis (HP:0100761)2.45072909
54Renal dysplasia (HP:0000110)2.43500363
55Coxa valga (HP:0002673)2.37034573
56Prolonged QT interval (HP:0001657)2.32649040
57Hamartoma of the eye (HP:0010568)2.30028261
58Bronchomalacia (HP:0002780)2.28783202
59Aplasia/hypoplasia of the femur (HP:0005613)2.27744267
60Infantile muscular hypotonia (HP:0008947)2.27537390
61Shallow orbits (HP:0000586)2.26390261
62Hemangiomatosis (HP:0007461)2.26231174
63Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.25273101
64Atelectasis (HP:0100750)2.20639583
65Abnormality of the ischium (HP:0003174)2.18782707
66Broad nasal tip (HP:0000455)2.18397139
67Increased connective tissue (HP:0009025)2.13092570
68Iris hypopigmentation (HP:0007730)2.12767407
69Bradycardia (HP:0001662)2.08079887
70Wide nose (HP:0000445)2.01778356
71Bell-shaped thorax (HP:0001591)2.01224209
72Aneurysm (HP:0002617)2.00781834
73Pulmonary artery stenosis (HP:0004415)1.99866699
74Hepatosplenomegaly (HP:0001433)1.92564276
75Abnormal atrioventricular conduction (HP:0005150)1.89883452
76Heart block (HP:0012722)1.89639552
77Tubular atrophy (HP:0000092)1.88639079
78Generalized hypopigmentation (HP:0007513)1.87093627
79Emphysema (HP:0002097)1.80833601
80Hypertriglyceridemia (HP:0002155)1.80280551
81Concave nail (HP:0001598)1.78133637
82Glioma (HP:0009733)1.76317407
83Sparse lateral eyebrow (HP:0005338)1.73813499
84Pulmonary hypertension (HP:0002092)1.70146481
85Nonimmune hydrops fetalis (HP:0001790)1.70055636
86Soft skin (HP:0000977)1.69476611
87Hyperacusis (HP:0010780)1.63108946
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62854236
89Spinal rigidity (HP:0003306)1.62769898
90Skin nodule (HP:0200036)1.62105650
91Aortic aneurysm (HP:0004942)1.61599714
92Renal salt wasting (HP:0000127)1.57269150
93Stage 5 chronic kidney disease (HP:0003774)1.55962541
94Progressive neurologic deterioration (HP:0002344)1.54775435
95Microdontia (HP:0000691)1.54251720
96Syncope (HP:0001279)1.53846506
97Protrusio acetabuli (HP:0003179)1.53150422
98Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.52661839
99Osteoarthritis (HP:0002758)1.52023936
100Difficulty running (HP:0009046)1.51199771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNK25.35841551
2NME14.76434868
3TRIB34.37747559
4SIK13.41502187
5BMX2.94943428
6ERBB22.92998796
7KDR2.84441824
8MAP2K62.47816404
9PKN22.30625385
10MAP3K72.27305001
11RPS6KA22.26162000
12MST1R2.12898250
13MARK21.98694898
14RPS6KL11.95916093
15RPS6KC11.95916093
16MAPK151.86302569
17ERN11.83126287
18RPS6KA61.76886888
19MAP3K61.75027212
20ZAP701.59346322
21NTRK31.59038066
22MUSK1.52588129
23RIPK11.51242174
24EEF2K1.50304677
25TESK11.46770036
26MAP3K131.35289429
27PDGFRB1.28723091
28MAPK71.27583125
29IKBKE1.23581374
30HIPK21.21940518
31EPHA21.18473307
32TBK11.17768521
33PRKD21.13359661
34MET1.10173000
35MTOR1.09644777
36CHUK1.04447433
37PTK61.03546375
38FER0.93995767
39PTK2B0.92636074
40PRKCI0.91089480
41PDGFRA0.89683350
42NEK60.89308111
43STK380.88761986
44PAK40.87911226
45MAP4K10.86783131
46SIK20.85015311
47TLK10.84159838
48CAMK10.83430627
49PRKAA20.81215883
50PTK20.80985463
51PRKAA10.78828918
52MYLK0.78809735
53TIE10.76452265
54PINK10.76118470
55ROCK10.74409823
56PRKD10.73810027
57MAPK80.72017225
58INSRR0.70575685
59MARK30.70568741
60CDC42BPA0.70428186
61MAP3K140.68073210
62MAPKAPK30.61715818
63MAPK40.57057304
64MAPK30.54899269
65TEC0.53049394
66FRK0.51219608
67GRK60.51190661
68PRKD30.50277343
69SIK30.49751107
70RPS6KA10.48598162
71MAPK10.48313337
72STK390.47042277
73RIPK40.46861618
74WNK40.44813171
75MAPK100.44269821
76EPHB10.43901061
77DYRK1B0.43737151
78MAP3K110.38629440
79ICK0.38450619
80MATK0.37443937
81TYK20.36784726
82TGFBR20.35717043
83OXSR10.35579054
84MAPK120.35473330
85PKN10.33537399
86PDPK10.33165257
87KIT0.32976435
88FGFR40.32784716
89CAMKK10.32589021
90JAK30.32283599
91MAPKAPK20.32266834
92CDK30.32181448
93IKBKB0.30922655
94SRC0.30645428
95RPS6KA50.30487730
96STK38L0.30029923
97JAK10.29740469
98DDR20.28631965
99MAP3K100.27870013
100ILK0.27640636

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.95051018
2Notch signaling pathway_Homo sapiens_hsa043303.77252295
3Other glycan degradation_Homo sapiens_hsa005113.32382879
4Glycerophospholipid metabolism_Homo sapiens_hsa005642.89482436
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.45145406
6ECM-receptor interaction_Homo sapiens_hsa045122.37120908
7Caffeine metabolism_Homo sapiens_hsa002322.07330366
8Longevity regulating pathway - mammal_Homo sapiens_hsa042111.96485031
9Choline metabolism in cancer_Homo sapiens_hsa052311.95350855
10Phospholipase D signaling pathway_Homo sapiens_hsa040721.86629132
11Glycerolipid metabolism_Homo sapiens_hsa005611.85253560
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82815258
13ABC transporters_Homo sapiens_hsa020101.76380859
14mTOR signaling pathway_Homo sapiens_hsa041501.73304328
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.64415663
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63614216
17Regulation of autophagy_Homo sapiens_hsa041401.61222528
18Focal adhesion_Homo sapiens_hsa045101.56345753
19Tight junction_Homo sapiens_hsa045301.34346111
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31647718
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.28497757
22Ovarian steroidogenesis_Homo sapiens_hsa049131.25251190
23AMPK signaling pathway_Homo sapiens_hsa041521.24634206
24Linoleic acid metabolism_Homo sapiens_hsa005911.24007518
25VEGF signaling pathway_Homo sapiens_hsa043701.21230992
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16668584
27Lysine degradation_Homo sapiens_hsa003101.14780947
28Estrogen signaling pathway_Homo sapiens_hsa049151.14296422
29Axon guidance_Homo sapiens_hsa043601.09668028
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06274050
31GnRH signaling pathway_Homo sapiens_hsa049121.05838540
32Acute myeloid leukemia_Homo sapiens_hsa052211.03218652
33Insulin signaling pathway_Homo sapiens_hsa049101.02495885
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02329439
35Insulin secretion_Homo sapiens_hsa049111.00990998
36Ether lipid metabolism_Homo sapiens_hsa005650.94400323
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91722749
38Dorso-ventral axis formation_Homo sapiens_hsa043200.91093418
39Protein digestion and absorption_Homo sapiens_hsa049740.85186086
40Insulin resistance_Homo sapiens_hsa049310.84901105
41Endocytosis_Homo sapiens_hsa041440.83428018
42Platelet activation_Homo sapiens_hsa046110.83142229
43PPAR signaling pathway_Homo sapiens_hsa033200.82587167
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82143979
45Dilated cardiomyopathy_Homo sapiens_hsa054140.82084892
46Lysosome_Homo sapiens_hsa041420.80945007
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.76264120
48Oxytocin signaling pathway_Homo sapiens_hsa049210.75977764
49Gap junction_Homo sapiens_hsa045400.74811119
50Chronic myeloid leukemia_Homo sapiens_hsa052200.71624283
51Inositol phosphate metabolism_Homo sapiens_hsa005620.70390082
52ErbB signaling pathway_Homo sapiens_hsa040120.67284911
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67135226
54Sphingolipid metabolism_Homo sapiens_hsa006000.63447617
55Melanogenesis_Homo sapiens_hsa049160.63200750
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62979930
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62385672
58Circadian rhythm_Homo sapiens_hsa047100.62215402
59Arachidonic acid metabolism_Homo sapiens_hsa005900.59609625
60Rap1 signaling pathway_Homo sapiens_hsa040150.58478230
61MAPK signaling pathway_Homo sapiens_hsa040100.56963383
62Hepatitis C_Homo sapiens_hsa051600.56385470
63cAMP signaling pathway_Homo sapiens_hsa040240.56142233
64Small cell lung cancer_Homo sapiens_hsa052220.56047246
65TNF signaling pathway_Homo sapiens_hsa046680.54864486
66Proteoglycans in cancer_Homo sapiens_hsa052050.54510126
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.53535086
68Glutathione metabolism_Homo sapiens_hsa004800.52446672
69Ras signaling pathway_Homo sapiens_hsa040140.51622485
70Prostate cancer_Homo sapiens_hsa052150.50825266
71Gastric acid secretion_Homo sapiens_hsa049710.50513960
72Prolactin signaling pathway_Homo sapiens_hsa049170.50194222
73Bile secretion_Homo sapiens_hsa049760.48457916
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48346741
75Malaria_Homo sapiens_hsa051440.48213225
76Renin secretion_Homo sapiens_hsa049240.47996241
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47287990
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46823855
79Taste transduction_Homo sapiens_hsa047420.44451712
80Glucagon signaling pathway_Homo sapiens_hsa049220.44318983
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43602301
82Salivary secretion_Homo sapiens_hsa049700.41581084
83Nitrogen metabolism_Homo sapiens_hsa009100.41386263
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.41106357
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39573293
86Collecting duct acid secretion_Homo sapiens_hsa049660.39077658
87Apoptosis_Homo sapiens_hsa042100.38449071
88Circadian entrainment_Homo sapiens_hsa047130.37376654
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37030174
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36855842
91Glioma_Homo sapiens_hsa052140.35904640
92Fructose and mannose metabolism_Homo sapiens_hsa000510.35641209
93Pathways in cancer_Homo sapiens_hsa052000.33664815
94Fatty acid biosynthesis_Homo sapiens_hsa000610.33647178
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32885852
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32394548
97Endometrial cancer_Homo sapiens_hsa052130.30845538
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30536497
99Chemical carcinogenesis_Homo sapiens_hsa052040.29885378
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29881052

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