ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	7.65511225
2	response to pheromone (GO:0019236)	6.95217409
3	negative regulation of cAMP-mediated signaling (GO:0043951)	6.91721694
4	positive regulation of receptor recycling (GO:0001921)	6.16577395
5	regulation of sequestering of triglyceride (GO:0010889)	5.52268793
6	adult feeding behavior (GO:0008343)	4.84220429
7	relaxation of cardiac muscle (GO:0055119)	4.76579434
8	regulation of protein glycosylation (GO:0060049)	4.71017778
9	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.33742640
10	regulation of non-canonical Wnt signaling pathway (GO:2000050)	4.20633790
11	muscle atrophy (GO:0014889)	4.12997544
12	opioid receptor signaling pathway (GO:0038003)	4.11452605
13	histone H3-K36 demethylation (GO:0070544)	4.08272059
14	striated muscle atrophy (GO:0014891)	3.98474783
15	cellular response to ATP (GO:0071318)	3.97798087
16	regulation of energy homeostasis (GO:2000505)	3.95581048
17	regulation of acrosome reaction (GO:0060046)	3.80131902
18	plasma membrane fusion (GO:0045026)	3.78655978
19	regulation of plasminogen activation (GO:0010755)	3.71978374
20	energy homeostasis (GO:0097009)	3.69528387
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.56428228
22	ether lipid metabolic process (GO:0046485)	3.55275827
23	homocysteine metabolic process (GO:0050667)	3.54705249
24	skeletal muscle adaptation (GO:0043501)	3.47150600
25	establishment of protein localization to Golgi (GO:0072600)	3.41907043
26	positive regulation of cAMP-mediated signaling (GO:0043950)	3.39233457
27	sphingosine metabolic process (GO:0006670)	3.36007987
28	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.32570802
29	behavioral response to ethanol (GO:0048149)	3.30889282
30	white fat cell differentiation (GO:0050872)	3.30219041
31	microtubule nucleation (GO:0007020)	3.29497318
32	response to caffeine (GO:0031000)	3.28040355
33	cellular response to ethanol (GO:0071361)	3.11679574
34	regulation of receptor recycling (GO:0001919)	3.07297813
35	protein targeting to Golgi (GO:0000042)	3.03713059
36	protein targeting to vacuole (GO:0006623)	2.96981215
37	protein targeting to lysosome (GO:0006622)	2.96981215
38	establishment of protein localization to vacuole (GO:0072666)	2.96981215
39	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.96401070
40	sphingoid metabolic process (GO:0046519)	2.94857322
41	iron ion import (GO:0097286)	2.93071926
42	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.89844906
43	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.88924332
44	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.85354203
45	regulation of skeletal muscle contraction (GO:0014819)	2.85082150
46	termination of G-protein coupled receptor signaling pathway (GO:0038032)	2.79162385
47	diol metabolic process (GO:0034311)	2.78997003
48	indolalkylamine metabolic process (GO:0006586)	2.78195625
49	peptidyl-threonine dephosphorylation (GO:0035970)	2.78071717
50	import into cell (GO:0098657)	2.77831589
51	cellular response to ammonium ion (GO:0071242)	2.76402968
52	regulation of cAMP-mediated signaling (GO:0043949)	2.73333781
53	regulation of translational termination (GO:0006449)	2.71720012
54	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.71695723
55	alternative mRNA splicing, via spliceosome (GO:0000380)	2.71573878
56	adenosine metabolic process (GO:0046085)	2.65922100
57	histone H3-K4 methylation (GO:0051568)	2.63974902
58	indole-containing compound catabolic process (GO:0042436)	2.62021469
59	indolalkylamine catabolic process (GO:0046218)	2.62021469
60	tryptophan catabolic process (GO:0006569)	2.62021469
61	pathway-restricted SMAD protein phosphorylation (GO:0060389)	2.60949957
62	desmosome organization (GO:0002934)	2.59589972
63	inner ear receptor cell development (GO:0060119)	2.59553376
64	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.58839574
65	positive regulation of meiosis (GO:0045836)	2.57504144
66	purine nucleotide salvage (GO:0032261)	2.54506361
67	positive regulation of fatty acid oxidation (GO:0046321)	2.52337977
68	relaxation of muscle (GO:0090075)	2.51847912
69	DNA replication-dependent nucleosome assembly (GO:0006335)	2.51784719
70	DNA replication-dependent nucleosome organization (GO:0034723)	2.51784719
71	sulfation (GO:0051923)	2.49270117
72	termination of signal transduction (GO:0023021)	2.48946362
73	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.48123327
74	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.47253710
75	kynurenine metabolic process (GO:0070189)	2.47218195
76	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.47030549
77	negative regulation of hormone biosynthetic process (GO:0032353)	2.46929410
78	interleukin-6-mediated signaling pathway (GO:0070102)	2.46104720
79	hepatocyte apoptotic process (GO:0097284)	2.43993817
80	cellular response to alkaloid (GO:0071312)	2.41441531
81	positive regulation of meiotic cell cycle (GO:0051446)	2.40336000
82	cytoplasmic mRNA processing body assembly (GO:0033962)	2.39809840
83	cellular response to epinephrine stimulus (GO:0071872)	2.39269772
84	negative regulation of systemic arterial blood pressure (GO:0003085)	2.38126466
85	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.37610201
86	positive regulation of muscle hypertrophy (GO:0014742)	2.37610201
87	regulation of tight junction assembly (GO:2000810)	2.37271625
88	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.36686426
89	regulation of meiosis I (GO:0060631)	2.36017479
90	primary amino compound metabolic process (GO:1901160)	2.34460705
91	phospholipid translocation (GO:0045332)	2.34444759
92	lipid translocation (GO:0034204)	2.34444759
93	folic acid-containing compound biosynthetic process (GO:0009396)	2.33684887
94	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.33117685
95	response to ATP (GO:0033198)	2.32521584
96	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.31790857
97	regulation of establishment of cell polarity (GO:2000114)	2.29973552
98	positive regulation of glycolytic process (GO:0045821)	2.29666032
99	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.28788334
100	acrosome assembly (GO:0001675)	2.28316384

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	4.40975426
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.17498210
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.98964194
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.82673036
5	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.78496742
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.78287447
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.72738488
8	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.70379858
9	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.34521528
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.24692460
11	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.19736852
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.14057563
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13070356
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09749645
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.01498698
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.98181485
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97899706
18	TP53_16413492_ChIP-PET_HCT116_Human	1.97424167
19	VDR_22108803_ChIP-Seq_LS180_Human	1.85686761
20	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.74907391
21	STAT3_23295773_ChIP-Seq_U87_Human	1.73344810
22	CDX2_22108803_ChIP-Seq_LS180_Human	1.70716976
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.70009295
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.67735225
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.67610365
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66307193
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63702339
28	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63702339
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59709510
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.57479905
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.54843876
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51964108
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.50696039
34	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50385140
35	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.49716290
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48304090
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47835183
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.47724128
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47724128
40	FUS_26573619_Chip-Seq_HEK293_Human	1.45918440
41	TCF4_23295773_ChIP-Seq_U87_Human	1.45381005
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.44435676
43	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.43650607
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42743583
45	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.42457821
46	P300_19829295_ChIP-Seq_ESCs_Human	1.39057586
47	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.37754915
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37464610
49	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.36384304
50	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.34179597
51	EWS_26573619_Chip-Seq_HEK293_Human	1.33583063
52	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33176175
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32347024
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31521371
55	TP53_18474530_ChIP-ChIP_U2OS_Human	1.31437959
56	IGF1R_20145208_ChIP-Seq_DFB_Human	1.30666533
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28838200
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.26289185
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26018133
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25370944
61	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24885647
62	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.23121597
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22365569
64	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.21436429
65	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20175333
66	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.19536049
67	RXR_22108803_ChIP-Seq_LS180_Human	1.19459250
68	RUNX_20019798_ChIP-Seq_JUKART_Human	1.18763247
69	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.18434652
70	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.18140205
71	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.16799439
72	KDM2B_26808549_Chip-Seq_REH_Human	1.16307190
73	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.15692915
74	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.15692915
75	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.15333774
76	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.13380428
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12882140
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11862261
79	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.11860842
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.11583410
81	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11248337
82	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11248337
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10392061
84	AHR_22903824_ChIP-Seq_MCF-7_Human	1.09943574
85	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.09419904
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09224348
87	AR_25329375_ChIP-Seq_VCAP_Human	1.09089524
88	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.08576085
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07863641
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07643049
91	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.06946067
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06393181
93	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.04008240
94	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.03012622
95	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.02394940
96	CJUN_26792858_Chip-Seq_BT549_Human	1.02349252
97	TCF4_22108803_ChIP-Seq_LS180_Human	1.02346469
98	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02114477
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00886536
100	SCL_19346495_ChIP-Seq_HPC-7_Human	1.00774921

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	3.47877905
2	MP0003646_muscle_fatigue	3.46885327
3	MP0002876_abnormal_thyroid_physiology	3.36593033
4	MP0003045_fibrosis	3.35782085
5	MP0005646_abnormal_pituitary_gland	3.35100559
6	MP0009780_abnormal_chondrocyte_physiolo	3.10235785
7	MP0004130_abnormal_muscle_cell	3.03927278
8	MP0003195_calcinosis	2.92029750
9	MP0003183_abnormal_peptide_metabolism	2.87886349
10	MP0000569_abnormal_digit_pigmentation	2.64674916
11	MP0000749_muscle_degeneration	2.28986451
12	MP0008057_abnormal_DNA_replication	2.23406599
13	MP0003724_increased_susceptibility_to	2.05807761
14	MP0001661_extended_life_span	2.05576409
15	MP0005670_abnormal_white_adipose	2.04102909
16	MP0000013_abnormal_adipose_tissue	2.01186951
17	MP0003950_abnormal_plasma_membrane	1.88296712
18	MP0009764_decreased_sensitivity_to	1.81834370
19	MP0003656_abnormal_erythrocyte_physiolo	1.72549216
20	MP0004145_abnormal_muscle_electrophysio	1.71320058
21	MP0002332_abnormal_exercise_endurance	1.70704356
22	MP0009046_muscle_twitch	1.64195287
23	MP0003787_abnormal_imprinting	1.61341748
24	MP0002971_abnormal_brown_adipose	1.60176600
25	MP0005503_abnormal_tendon_morphology	1.58961996
26	MP0004484_altered_response_of	1.56011152
27	MP0008775_abnormal_heart_ventricle	1.52916657
28	MP0002166_altered_tumor_susceptibility	1.49127754
29	MP0004147_increased_porphyrin_level	1.48377003
30	MP0003633_abnormal_nervous_system	1.47245756
31	MP0001968_abnormal_touch/_nociception	1.43104730
32	MP0002168_other_aberrant_phenotype	1.42203722
33	MP0002693_abnormal_pancreas_physiology	1.42174395
34	MP0000750_abnormal_muscle_regeneration	1.40994054
35	MP0005379_endocrine/exocrine_gland_phen	1.34031958
36	MP0000003_abnormal_adipose_tissue	1.33691060
37	MP0003221_abnormal_cardiomyocyte_apopto	1.30173787
38	MP0001664_abnormal_digestion	1.28224350
39	MP0005164_abnormal_response_to	1.22426992
40	MP0002909_abnormal_adrenal_gland	1.21652934
41	MP0005551_abnormal_eye_electrophysiolog	1.20817425
42	MP0004885_abnormal_endolymph	1.20275830
43	MP0001756_abnormal_urination	1.17294285
44	MP0003172_abnormal_lysosome_physiology	1.15232582
45	MP0004036_abnormal_muscle_relaxation	1.14671381
46	MP0000516_abnormal_urinary_system	1.13037386
47	MP0005367_renal/urinary_system_phenotyp	1.13037386
48	MP0000230_abnormal_systemic_arterial	1.12830916
49	MP0002006_tumorigenesis	1.12344368
50	MP0004134_abnormal_chest_morphology	1.07326158
51	MP0002078_abnormal_glucose_homeostasis	1.07279977
52	MP0001944_abnormal_pancreas_morphology	1.06898755
53	MP0005369_muscle_phenotype	1.06387001
54	MP0002108_abnormal_muscle_morphology	1.04593927
55	MP0002106_abnormal_muscle_physiology	1.04327288
56	MP0004215_abnormal_myocardial_fiber	1.01449927
57	MP0003879_abnormal_hair_cell	1.00461710
58	MP0004510_myositis	1.00319495
59	MP0000681_abnormal_thyroid_gland	1.00276035
60	MP0003121_genomic_imprinting	0.99443647
61	MP0004043_abnormal_pH_regulation	0.98732854
62	MP0009278_abnormal_bone_marrow	0.97364274
63	MP0010352_gastrointestinal_tract_polyps	0.94828069
64	MP0005266_abnormal_metabolism	0.92836031
65	MP0001851_eye_inflammation	0.92527935
66	MP0003631_nervous_system_phenotype	0.90903927
67	MP0005376_homeostasis/metabolism_phenot	0.89940685
68	MP0005620_abnormal_muscle_contractility	0.89734013
69	MP0001440_abnormal_grooming_behavior	0.88527430
70	MP0002837_dystrophic_cardiac_calcinosis	0.86560237
71	MP0002138_abnormal_hepatobiliary_system	0.86330614
72	MP0008995_early_reproductive_senescence	0.85795389
73	MP0005332_abnormal_amino_acid	0.85747520
74	MP0000747_muscle_weakness	0.84656140
75	MP0000015_abnormal_ear_pigmentation	0.81118158
76	MP0006035_abnormal_mitochondrial_morpho	0.80831671
77	MP0003638_abnormal_response/metabolism_	0.79692694
78	MP0005334_abnormal_fat_pad	0.79254184
79	MP0001501_abnormal_sleep_pattern	0.79178300
80	MP0004883_abnormal_blood_vessel	0.78857506
81	MP0004087_abnormal_muscle_fiber	0.78419820
82	MP0004381_abnormal_hair_follicle	0.78087295
83	MP0004084_abnormal_cardiac_muscle	0.77986849
84	MP0000538_abnormal_urinary_bladder	0.76907535
85	MP0003122_maternal_imprinting	0.76461774
86	MP0004142_abnormal_muscle_tone	0.73254264
87	MP0000639_abnormal_adrenal_gland	0.72388684
88	MP0002095_abnormal_skin_pigmentation	0.72019980
89	MP0009333_abnormal_splenocyte_physiolog	0.70935380
90	MP0003705_abnormal_hypodermis_morpholog	0.69622070
91	MP0002269_muscular_atrophy	0.69333444
92	MP0003252_abnormal_bile_duct	0.68325052
93	MP0002272_abnormal_nervous_system	0.67818058
94	MP0003632_abnormal_nervous_system	0.67593381
95	MP0005397_hematopoietic_system_phenotyp	0.66982566
96	MP0001545_abnormal_hematopoietic_system	0.66982566
97	MP0001270_distended_abdomen	0.66022613
98	MP0004185_abnormal_adipocyte_glucose	0.65270246
99	MP0005452_abnormal_adipose_tissue	0.64108667
100	MP0002229_neurodegeneration	0.63420646

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	5.97570648
2	Mesomelia (HP:0003027)	4.77446402
3	Retrobulbar optic neuritis (HP:0100654)	4.75361354
4	Optic neuritis (HP:0100653)	4.75361354
5	Orchitis (HP:0100796)	4.71345160
6	Myositis (HP:0100614)	4.65427917
7	Anorexia (HP:0002039)	3.62666772
8	Esophageal varix (HP:0002040)	3.59218335
9	Intestinal atresia (HP:0011100)	3.46104170
10	Congenital sensorineural hearing impairment (HP:0008527)	3.40775884
11	Large for gestational age (HP:0001520)	3.27356466
12	Abnormality of homocysteine metabolism (HP:0010919)	3.22248443
13	Homocystinuria (HP:0002156)	3.22248443
14	Constricted visual fields (HP:0001133)	3.21190550
15	Volvulus (HP:0002580)	3.17874332
16	Arterial thrombosis (HP:0004420)	3.13929454
17	Sex reversal (HP:0012245)	3.12774614
18	Abnormal sex determination (HP:0012244)	3.12774614
19	Spontaneous hematomas (HP:0007420)	3.09702271
20	Keratoconjunctivitis sicca (HP:0001097)	3.02847603
21	Autoimmune hemolytic anemia (HP:0001890)	2.98244066
22	Abnormality of alanine metabolism (HP:0010916)	2.89923611
23	Hyperalaninemia (HP:0003348)	2.89923611
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.89923611
25	Keratoconjunctivitis (HP:0001096)	2.80428283
26	Pulmonary embolism (HP:0002204)	2.78138173
27	Elevated erythrocyte sedimentation rate (HP:0003565)	2.72383585
28	Difficulty running (HP:0009046)	2.71066841
29	Patchy hypopigmentation of hair (HP:0011365)	2.66138382
30	Gaze-evoked nystagmus (HP:0000640)	2.63809179
31	Myocardial infarction (HP:0001658)	2.61986096
32	Large eyes (HP:0001090)	2.59761149
33	Ketoacidosis (HP:0001993)	2.58484026
34	Hyporeflexia of lower limbs (HP:0002600)	2.54331721
35	Testicular neoplasm (HP:0010788)	2.50819793
36	Abnormality of the pancreatic islet cells (HP:0006476)	2.49435780
37	Abnormality of endocrine pancreas physiology (HP:0012093)	2.49435780
38	Peritonitis (HP:0002586)	2.47600750
39	Abnormality of the fingertips (HP:0001211)	2.46501390
40	Attenuation of retinal blood vessels (HP:0007843)	2.34604367
41	Hemoptysis (HP:0002105)	2.33458800
42	Portal hypertension (HP:0001409)	2.30514049
43	White forelock (HP:0002211)	2.28994303
44	Arthropathy (HP:0003040)	2.26026271
45	Conjunctival telangiectasia (HP:0000524)	2.25219308
46	Oligodontia (HP:0000677)	2.23880440
47	Pancreatic islet-cell hyperplasia (HP:0004510)	2.23493722
48	Abnormality of the pericardium (HP:0001697)	2.22158553
49	Chorioretinal atrophy (HP:0000533)	2.22022376
50	Reduced subcutaneous adipose tissue (HP:0003758)	2.21759518
51	Hypoalphalipoproteinemia (HP:0003233)	2.18690039
52	Abnormal glucose tolerance (HP:0001952)	2.18520211
53	Median cleft lip (HP:0000161)	2.17966822
54	Genetic anticipation (HP:0003743)	2.17733372
55	Glucose intolerance (HP:0000833)	2.14496487
56	Progressive cerebellar ataxia (HP:0002073)	2.13876918
57	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.13739484
58	Hamartoma of the eye (HP:0010568)	2.12900402
59	Thrombophlebitis (HP:0004418)	2.11337522
60	Abnormality of the hepatic vasculature (HP:0006707)	2.07808172
61	Action tremor (HP:0002345)	2.07520180
62	Agitation (HP:0000713)	2.06355519
63	Broad palm (HP:0001169)	2.03160283
64	Late onset (HP:0003584)	1.98777808
65	Hematochezia (HP:0002573)	1.96962961
66	Abnormality of the renal cortex (HP:0011035)	1.96457551
67	Vertigo (HP:0002321)	1.95713024
68	Muscular dystrophy (HP:0003560)	1.90702422
69	Insulin-resistant diabetes mellitus (HP:0000831)	1.90490100
70	Gangrene (HP:0100758)	1.89108184
71	Recurrent bacterial skin infections (HP:0005406)	1.86957389
72	Oligomenorrhea (HP:0000876)	1.86322472
73	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.84252351
74	Gingival bleeding (HP:0000225)	1.83928051
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81892103
76	Persistence of primary teeth (HP:0006335)	1.81710760
77	Wrist flexion contracture (HP:0001239)	1.81028865
78	Pulmonary infiltrates (HP:0002113)	1.77740493
79	Chronic hepatic failure (HP:0100626)	1.76180108
80	Anxiety (HP:0000739)	1.75501344
81	Truncal obesity (HP:0001956)	1.73355492
82	Tetraparesis (HP:0002273)	1.72528061
83	Vasculitis (HP:0002633)	1.72060656
84	Renal cortical cysts (HP:0000803)	1.71419767
85	Papillary thyroid carcinoma (HP:0002895)	1.70795275
86	Focal seizures (HP:0007359)	1.70571215
87	Hypothermia (HP:0002045)	1.70418098
88	Goiter (HP:0000853)	1.69784913
89	Poor speech (HP:0002465)	1.69122555
90	Overgrowth (HP:0001548)	1.68944341
91	Paresthesia (HP:0003401)	1.67956079
92	Striae distensae (HP:0001065)	1.65549052
93	Hypoplastic labia majora (HP:0000059)	1.64958774
94	Thickened helices (HP:0000391)	1.64731897
95	Abnormality of the columella (HP:0009929)	1.64015673
96	Hyperglycemia (HP:0003074)	1.63723175
97	Pigmentary retinal degeneration (HP:0001146)	1.60676782
98	Abnormality of T cell number (HP:0011839)	1.59437231
99	Poor head control (HP:0002421)	1.59268814
100	Abnormality of the labia majora (HP:0012881)	1.59010049

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.44660352
2	FES	4.71390838
3	FER	4.19004329
4	ACVR1B	4.00153670
5	ADRBK2	3.68862944
6	MAP2K6	3.14309325
7	AKT3	2.94515440
8	OBSCN	2.51752497
9	PINK1	2.28422576
10	SGK2	1.98066796
11	PNCK	1.88379786
12	MAP2K3	1.85708246
13	IRAK1	1.75843282
14	ADRBK1	1.63224574
15	CAMK1	1.58247477
16	PIK3CG	1.58010715
17	FGFR3	1.57562983
18	PRKCE	1.50294595
19	BMPR1B	1.49698005
20	SGK223	1.49504326
21	SGK494	1.49504326
22	EPHA3	1.45205634
23	JAK3	1.44079041
24	NLK	1.43461957
25	PKN2	1.31457899
26	SGK3	1.24090662
27	FGFR2	1.19961017
28	TGFBR2	1.14808214
29	FGR	1.09513472
30	GRK1	1.04340202
31	PLK2	1.03801175
32	GRK6	0.98278837
33	TGFBR1	0.92597972
34	MAP3K3	0.91461354
35	WNK1	0.88587708
36	NEK9	0.85810232
37	BLK	0.84264833
38	JAK2	0.82659556
39	NTRK3	0.79909693
40	MST4	0.79044716
41	CAMK1G	0.77972286
42	ERN1	0.77244956
43	TAOK3	0.75933039
44	TRPM7	0.72325248
45	JAK1	0.69692128
46	PTK2B	0.68748848
47	FLT3	0.64530459
48	SGK1	0.63952534
49	MAP3K7	0.62726307
50	MAPK11	0.62704298
51	ERBB2	0.59298938
52	MAP2K1	0.57654544
53	PRKD2	0.57059028
54	HIPK2	0.56395339
55	PRKAA2	0.53221784
56	CSNK1A1	0.51420887
57	GRK5	0.51357311
58	ZAP70	0.51126694
59	GRK7	0.50782329
60	MAP3K2	0.49611916
61	MYLK	0.49403708
62	MAP3K14	0.49254457
63	CAMK2A	0.47984205
64	RPS6KB2	0.45819257
65	PHKG2	0.45562702
66	PHKG1	0.45562702
67	UHMK1	0.45446313
68	MELK	0.45377212
69	TXK	0.42920603
70	IRAK2	0.42633043
71	MAP3K6	0.42167357
72	PRKCG	0.41150379
73	CAMK4	0.40224678
74	STK24	0.38726479
75	NEK6	0.38554814
76	IRAK3	0.37852162
77	FGFR4	0.37203913
78	PRKD1	0.36704230
79	STK38L	0.36529493
80	FGFR1	0.36023293
81	NTRK2	0.35493863
82	CHUK	0.34454893
83	PAK3	0.33307372
84	ITK	0.33208208
85	MAP3K1	0.33053751
86	IKBKB	0.32883376
87	CDK9	0.31691865
88	PDK1	0.30179496
89	RPS6KB1	0.29993918
90	RET	0.29826802
91	PRKAA1	0.29202296
92	PRKCH	0.28729350
93	STK11	0.28668051
94	CSK	0.28047441
95	PIK3CA	0.27107534
96	TTN	0.26888985
97	KIT	0.26206033
98	IKBKE	0.26127802
99	RPS6KA3	0.23249763
100	PRKCQ	0.22825825

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.69567807
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.63071821
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.58351482
4	Morphine addiction_Homo sapiens_hsa05032	2.06598418
5	One carbon pool by folate_Homo sapiens_hsa00670	1.98615397
6	GABAergic synapse_Homo sapiens_hsa04727	1.97897346
7	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.79154467
8	ABC transporters_Homo sapiens_hsa02010	1.76209654
9	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.66926182
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38475915
11	Circadian entrainment_Homo sapiens_hsa04713	1.35817560
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34256877
13	Glycerolipid metabolism_Homo sapiens_hsa00561	1.33146755
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.32314292
15	Taste transduction_Homo sapiens_hsa04742	1.32107783
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28654588
17	Cholinergic synapse_Homo sapiens_hsa04725	1.28138503
18	Sphingolipid metabolism_Homo sapiens_hsa00600	1.28027561
19	Serotonergic synapse_Homo sapiens_hsa04726	1.27590591
20	Renin secretion_Homo sapiens_hsa04924	1.26609461
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.22353994
22	Complement and coagulation cascades_Homo sapiens_hsa04610	1.22266007
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20914662
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.19547121
25	Olfactory transduction_Homo sapiens_hsa04740	1.17965422
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.17051262
27	Regulation of autophagy_Homo sapiens_hsa04140	1.16855766
28	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.15125409
29	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.11249747
30	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.07009879
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.06689419
32	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.05389477
33	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.01761980
34	Insulin resistance_Homo sapiens_hsa04931	1.01202019
35	AMPK signaling pathway_Homo sapiens_hsa04152	1.00445891
36	Long-term depression_Homo sapiens_hsa04730	0.98687392
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.95984722
38	Insulin secretion_Homo sapiens_hsa04911	0.95615253
39	Sulfur metabolism_Homo sapiens_hsa00920	0.93621792
40	FoxO signaling pathway_Homo sapiens_hsa04068	0.92794973
41	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.90078197
42	Type II diabetes mellitus_Homo sapiens_hsa04930	0.89185195
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.89072364
44	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.88384862
45	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.88180581
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.86330048
47	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.85950522
48	Arginine biosynthesis_Homo sapiens_hsa00220	0.85080215
49	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.82696215
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.82184867
51	Galactose metabolism_Homo sapiens_hsa00052	0.81217730
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80889945
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80808620
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78628729
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.78619631
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77175736
57	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.76323296
58	Osteoclast differentiation_Homo sapiens_hsa04380	0.73586611
59	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.73340542
60	Prolactin signaling pathway_Homo sapiens_hsa04917	0.73130127
61	Platelet activation_Homo sapiens_hsa04611	0.71920071
62	Nicotine addiction_Homo sapiens_hsa05033	0.71818670
63	Glucagon signaling pathway_Homo sapiens_hsa04922	0.70733441
64	Gastric acid secretion_Homo sapiens_hsa04971	0.68584036
65	Butanoate metabolism_Homo sapiens_hsa00650	0.64966356
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63905135
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.63792188
68	Retinol metabolism_Homo sapiens_hsa00830	0.63487994
69	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.62828250
70	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.61313651
71	Circadian rhythm_Homo sapiens_hsa04710	0.60436020
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.59520961
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59463171
74	MAPK signaling pathway_Homo sapiens_hsa04010	0.56811836
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.55971097
76	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.55625175
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.53439380
78	Melanoma_Homo sapiens_hsa05218	0.52735827
79	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.52572334
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.52058267
81	Estrogen signaling pathway_Homo sapiens_hsa04915	0.51938826
82	Mineral absorption_Homo sapiens_hsa04978	0.48285759
83	PPAR signaling pathway_Homo sapiens_hsa03320	0.48258619
84	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.48020190
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.45589560
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45021921
87	Ras signaling pathway_Homo sapiens_hsa04014	0.44811319
88	Salivary secretion_Homo sapiens_hsa04970	0.43653266
89	Renin-angiotensin system_Homo sapiens_hsa04614	0.43227870
90	Alcoholism_Homo sapiens_hsa05034	0.41625324
91	TNF signaling pathway_Homo sapiens_hsa04668	0.41324817
92	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.39086990
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.38888530
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38312377
95	Prostate cancer_Homo sapiens_hsa05215	0.37442381
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.37099316
97	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.36504918
98	Chemokine signaling pathway_Homo sapiens_hsa04062	0.36438758
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36154975
100	Phototransduction_Homo sapiens_hsa04744	0.35778597

ATP8A2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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