ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adaptation of signaling pathway (GO:0023058)	6.95686824
2	L-fucose catabolic process (GO:0042355)	4.67118253
3	fucose catabolic process (GO:0019317)	4.67118253
4	L-fucose metabolic process (GO:0042354)	4.67118253
5	serotonin metabolic process (GO:0042428)	4.40635402
6	neuronal action potential (GO:0019228)	4.27849661
7	regulation of penile erection (GO:0060405)	4.20110219
8	indolalkylamine metabolic process (GO:0006586)	4.16951690
9	neuronal action potential propagation (GO:0019227)	4.15901407
10	primary amino compound metabolic process (GO:1901160)	3.87311070
11	retinal cone cell development (GO:0046549)	3.79748023
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.63622660
13	detection of light stimulus involved in visual perception (GO:0050908)	3.63622660
14	short-term memory (GO:0007614)	3.60174349
15	indole-containing compound metabolic process (GO:0042430)	3.58964261
16	tryptophan metabolic process (GO:0006568)	3.54036504
17	limb bud formation (GO:0060174)	3.50516205
18	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.47353683
19	kidney morphogenesis (GO:0060993)	3.44222224
20	behavioral response to ethanol (GO:0048149)	3.41491363
21	dopamine biosynthetic process (GO:0042416)	3.36362353
22	signal peptide processing (GO:0006465)	3.26491817
23	tryptophan catabolic process (GO:0006569)	3.25842428
24	indole-containing compound catabolic process (GO:0042436)	3.25842428
25	indolalkylamine catabolic process (GO:0046218)	3.25842428
26	tachykinin receptor signaling pathway (GO:0007217)	3.25364489
27	negative regulation of mast cell activation (GO:0033004)	3.22463374
28	protein K6-linked ubiquitination (GO:0085020)	3.21801203
29	cellular ketone body metabolic process (GO:0046950)	3.13668915
30	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.11259681
31	neural tube formation (GO:0001841)	3.11169647
32	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.08398185
33	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.08398185
34	regulation of translation, ncRNA-mediated (GO:0045974)	3.08398185
35	metallo-sulfur cluster assembly (GO:0031163)	3.07619938
36	iron-sulfur cluster assembly (GO:0016226)	3.07619938
37	DNA double-strand break processing (GO:0000729)	3.04377986
38	sulfation (GO:0051923)	3.04237677
39	piRNA metabolic process (GO:0034587)	3.02533616
40	presynaptic membrane assembly (GO:0097105)	3.01158712
41	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.99105417
42	multicellular organism reproduction (GO:0032504)	2.98216385
43	transmission of nerve impulse (GO:0019226)	2.96560222
44	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.93414576
45	regulation of feeding behavior (GO:0060259)	2.93353316
46	pyrimidine nucleobase catabolic process (GO:0006208)	2.92647820
47	epithelial cilium movement (GO:0003351)	2.91975864
48	protein heterotetramerization (GO:0051290)	2.89609831
49	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.89513827
50	nonmotile primary cilium assembly (GO:0035058)	2.88612342
51	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.88181820
52	behavioral response to nicotine (GO:0035095)	2.87822885
53	regulation of sarcomere organization (GO:0060297)	2.83746147
54	gamma-aminobutyric acid transport (GO:0015812)	2.81530367
55	membrane depolarization during action potential (GO:0086010)	2.80894471
56	kynurenine metabolic process (GO:0070189)	2.80423970
57	glutamate receptor signaling pathway (GO:0007215)	2.79723374
58	ketone body metabolic process (GO:1902224)	2.78261076
59	valine metabolic process (GO:0006573)	2.76536295
60	axoneme assembly (GO:0035082)	2.75345993
61	dopamine transport (GO:0015872)	2.72265886
62	platelet dense granule organization (GO:0060155)	2.67319222
63	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.65601477
64	action potential (GO:0001508)	2.62290223
65	L-methionine salvage (GO:0071267)	2.61828055
66	L-methionine biosynthetic process (GO:0071265)	2.61828055
67	amino acid salvage (GO:0043102)	2.61828055
68	catechol-containing compound biosynthetic process (GO:0009713)	2.60751310
69	catecholamine biosynthetic process (GO:0042423)	2.60751310
70	cellular biogenic amine catabolic process (GO:0042402)	2.60051800
71	amine catabolic process (GO:0009310)	2.60051800
72	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.58422086
73	inner ear receptor stereocilium organization (GO:0060122)	2.58024651
74	centriole replication (GO:0007099)	2.57491865
75	photoreceptor cell development (GO:0042461)	2.56695311
76	branched-chain amino acid catabolic process (GO:0009083)	2.55576621
77	methionine biosynthetic process (GO:0009086)	2.52294001
78	retina layer formation (GO:0010842)	2.52072191
79	spinal cord motor neuron differentiation (GO:0021522)	2.50749031
80	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.47410849
81	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.47060847
82	cell proliferation in forebrain (GO:0021846)	2.46942924
83	cilium organization (GO:0044782)	2.46710358
84	negative regulation of heart rate (GO:0010459)	2.46652626
85	intraciliary transport (GO:0042073)	2.45776606
86	male meiosis I (GO:0007141)	2.45663248
87	regulation of collateral sprouting (GO:0048670)	2.45219798
88	cysteine metabolic process (GO:0006534)	2.45163608
89	cilium assembly (GO:0042384)	2.43791583
90	DNA methylation involved in gamete generation (GO:0043046)	2.43692852
91	cilium morphogenesis (GO:0060271)	2.43512726
92	negative regulation of sodium ion transport (GO:0010766)	2.40682992
93	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.39662923
94	retinal ganglion cell axon guidance (GO:0031290)	2.39566436
95	eye photoreceptor cell development (GO:0042462)	2.39308981
96	cilium movement (GO:0003341)	2.39002847
97	synaptic transmission, cholinergic (GO:0007271)	2.38401353
98	water-soluble vitamin biosynthetic process (GO:0042364)	2.37194114
99	detection of calcium ion (GO:0005513)	2.37184781
100	protein complex biogenesis (GO:0070271)	2.36758917

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.48234608
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.27063393
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.06914515
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.97416956
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.93931215
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.84314254
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78010763
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71033688
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.61731387
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54768950
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52218543
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.35862719
13	P300_19829295_ChIP-Seq_ESCs_Human	2.19703110
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.13020766
15	FUS_26573619_Chip-Seq_HEK293_Human	2.08813372
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04453944
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95893162
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.91807817
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.87920847
20	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87920847
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86516214
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78999771
23	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.74587045
24	EWS_26573619_Chip-Seq_HEK293_Human	1.71204246
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69346335
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68400337
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68139167
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.68139167
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.67981931
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67109084
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.66225228
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.65203813
33	AR_25329375_ChIP-Seq_VCAP_Human	1.65044696
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64869376
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.62337083
36	STAT3_23295773_ChIP-Seq_U87_Human	1.58047851
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56002785
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.53793506
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.53568139
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52564512
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.51893707
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50378506
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.50324135
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49887793
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.48931135
46	TCF4_23295773_ChIP-Seq_U87_Human	1.46951652
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46111715
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46052527
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44863262
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43758670
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40224915
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35529780
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34988466
54	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.32343147
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.31942132
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30884681
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29213544
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28926872
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28751828
60	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28705627
61	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.27578921
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25915426
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25779791
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25773761
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25773761
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.24563921
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24189400
68	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21272512
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21040858
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20063874
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15870379
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.15405650
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14646889
74	TP53_16413492_ChIP-PET_HCT116_Human	1.13547547
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12609365
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12389332
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10770011
78	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.10486765
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10323892
80	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.09817766
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07401587
82	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07085931
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.06963402
84	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06950796
85	HTT_18923047_ChIP-ChIP_STHdh_Human	1.06686329
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06413868
87	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05933933
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05412700
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03159027
90	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.02605089
91	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.01046640
92	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00932805
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00847024
94	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00833850
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98978770
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.98785555
97	TP53_18474530_ChIP-ChIP_U2OS_Human	0.98459609
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.98270721
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97957491
100	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.97488869

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.53395220
2	MP0002102_abnormal_ear_morphology	3.28244080
3	MP0003195_calcinosis	3.26052368
4	MP0008877_abnormal_DNA_methylation	2.73257929
5	MP0006072_abnormal_retinal_apoptosis	2.68102625
6	MP0005551_abnormal_eye_electrophysiolog	2.66649825
7	MP0001486_abnormal_startle_reflex	2.54899350
8	MP0002638_abnormal_pupillary_reflex	2.52670813
9	MP0003136_yellow_coat_color	2.47810855
10	MP0000372_irregular_coat_pigmentation	2.45627659
11	MP0005423_abnormal_somatic_nervous	2.36134705
12	MP0009745_abnormal_behavioral_response	2.32350766
13	MP0003011_delayed_dark_adaptation	2.29492124
14	MP0001968_abnormal_touch/_nociception	2.25770952
15	MP0005253_abnormal_eye_physiology	2.15153480
16	MP0002822_catalepsy	2.12376712
17	MP0008058_abnormal_DNA_repair	2.05399641
18	MP0002736_abnormal_nociception_after	2.05226206
19	MP0006276_abnormal_autonomic_nervous	2.03612482
20	MP0005171_absent_coat_pigmentation	1.99990383
21	MP0004885_abnormal_endolymph	1.93210539
22	MP0001501_abnormal_sleep_pattern	1.92769979
23	MP0002272_abnormal_nervous_system	1.88801727
24	MP0003646_muscle_fatigue	1.87965187
25	MP0008057_abnormal_DNA_replication	1.82612847
26	MP0002938_white_spotting	1.76967586
27	MP0004742_abnormal_vestibular_system	1.72988987
28	MP0001984_abnormal_olfaction	1.72699236
29	MP0001986_abnormal_taste_sensitivity	1.72455326
30	MP0008872_abnormal_physiological_respon	1.63401940
31	MP0002572_abnormal_emotion/affect_behav	1.62498165
32	MP0006292_abnormal_olfactory_placode	1.58917532
33	MP0000569_abnormal_digit_pigmentation	1.58043162
34	MP0002735_abnormal_chemical_nociception	1.57424481
35	MP0003890_abnormal_embryonic-extraembry	1.51453795
36	MP0002876_abnormal_thyroid_physiology	1.50586771
37	MP0009046_muscle_twitch	1.49586785
38	MP0001529_abnormal_vocalization	1.46349210
39	MP0002557_abnormal_social/conspecific_i	1.46246730
40	MP0001188_hyperpigmentation	1.44219287
41	MP0009697_abnormal_copulation	1.43335971
42	MP0001485_abnormal_pinna_reflex	1.40561507
43	MP0002653_abnormal_ependyma_morphology	1.38250103
44	MP0004142_abnormal_muscle_tone	1.37959254
45	MP0004924_abnormal_behavior	1.35212464
46	MP0005386_behavior/neurological_phenoty	1.35212464
47	MP0004133_heterotaxia	1.34802208
48	MP0004147_increased_porphyrin_level	1.33537959
49	MP0002064_seizures	1.33065072
50	MP0005410_abnormal_fertilization	1.32881821
51	MP0003635_abnormal_synaptic_transmissio	1.24378047
52	MP0001905_abnormal_dopamine_level	1.22848636
53	MP0002067_abnormal_sensory_capabilities	1.17978613
54	MP0005174_abnormal_tail_pigmentation	1.12945026
55	MP0001970_abnormal_pain_threshold	1.12724089
56	MP0002063_abnormal_learning/memory/cond	1.11645302
57	MP0005248_abnormal_Harderian_gland	1.09589459
58	MP0003698_abnormal_male_reproductive	1.05155691
59	MP0002734_abnormal_mechanical_nocicepti	1.02902346
60	MP0005195_abnormal_posterior_eye	1.02658307
61	MP0003787_abnormal_imprinting	1.02627359
62	MP0001440_abnormal_grooming_behavior	1.02325974
63	MP0002160_abnormal_reproductive_system	1.02125718
64	MP0008875_abnormal_xenobiotic_pharmacok	0.98057988
65	MP0005167_abnormal_blood-brain_barrier	0.95682495
66	MP0002733_abnormal_thermal_nociception	0.95103602
67	MP0002752_abnormal_somatic_nervous	0.93810394
68	MP0002138_abnormal_hepatobiliary_system	0.90873459
69	MP0003119_abnormal_digestive_system	0.89914104
70	MP0005645_abnormal_hypothalamus_physiol	0.89405659
71	MP0005503_abnormal_tendon_morphology	0.87899312
72	MP0000778_abnormal_nervous_system	0.85966976
73	MP0000631_abnormal_neuroendocrine_gland	0.85848216
74	MP0001929_abnormal_gametogenesis	0.85745346
75	MP0001963_abnormal_hearing_physiology	0.85296533
76	MP0001502_abnormal_circadian_rhythm	0.85083857
77	MP0000955_abnormal_spinal_cord	0.84670682
78	MP0000026_abnormal_inner_ear	0.83550255
79	MP0002229_neurodegeneration	0.82019061
80	MP0000049_abnormal_middle_ear	0.81408941
81	MP0002277_abnormal_respiratory_mucosa	0.81313282
82	MP0002184_abnormal_innervation	0.80208695
83	MP0002090_abnormal_vision	0.79860248
84	MP0002210_abnormal_sex_determination	0.79583066
85	MP0005391_vision/eye_phenotype	0.79013881
86	MP0001324_abnormal_eye_pigmentation	0.78765867
87	MP0005647_abnormal_sex_gland	0.78651446
88	MP0002751_abnormal_autonomic_nervous	0.78362865
89	MP0002882_abnormal_neuron_morphology	0.77743730
90	MP0003638_abnormal_response/metabolism_	0.77195708
91	MP0002909_abnormal_adrenal_gland	0.76617670
92	MP0000427_abnormal_hair_cycle	0.74185156
93	MP0000653_abnormal_sex_gland	0.72878075
94	MP0003121_genomic_imprinting	0.72329932
95	MP0003122_maternal_imprinting	0.71812602
96	MP0005671_abnormal_response_to	0.71328437
97	MP0002069_abnormal_eating/drinking_beha	0.70770759
98	MP0002928_abnormal_bile_duct	0.70295013
99	MP0002095_abnormal_skin_pigmentation	0.70124838
100	MP0000383_abnormal_hair_follicle	0.69859273

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	4.43550136
2	Pancreatic fibrosis (HP:0100732)	3.99919635
3	True hermaphroditism (HP:0010459)	3.96656180
4	Pancreatic cysts (HP:0001737)	3.86846756
5	Abnormality of midbrain morphology (HP:0002418)	3.81618016
6	Molar tooth sign on MRI (HP:0002419)	3.81618016
7	Progressive inability to walk (HP:0002505)	3.73491957
8	Hyperventilation (HP:0002883)	3.53773455
9	Nephronophthisis (HP:0000090)	3.35493899
10	Type II lissencephaly (HP:0007260)	3.35045934
11	Congenital stationary night blindness (HP:0007642)	3.27418064
12	Abolished electroretinogram (ERG) (HP:0000550)	3.19134523
13	Hypothermia (HP:0002045)	3.16503793
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.12986267
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.12574793
16	Focal seizures (HP:0007359)	3.02968464
17	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.02334654
18	Attenuation of retinal blood vessels (HP:0007843)	2.96687457
19	Tubular atrophy (HP:0000092)	2.94787598
20	Inability to walk (HP:0002540)	2.84476013
21	Abnormality of the renal medulla (HP:0100957)	2.82954757
22	Intestinal atresia (HP:0011100)	2.77840702
23	Lissencephaly (HP:0001339)	2.77366775
24	Anencephaly (HP:0002323)	2.72822994
25	Polydipsia (HP:0001959)	2.70400852
26	Abnormal drinking behavior (HP:0030082)	2.70400852
27	Atonic seizures (HP:0010819)	2.65004302
28	Febrile seizures (HP:0002373)	2.63296210
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.61948372
30	Cerebellar dysplasia (HP:0007033)	2.57831377
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.57739400
32	Medial flaring of the eyebrow (HP:0010747)	2.56416325
33	Abnormality of the renal cortex (HP:0011035)	2.55897020
34	Short tibia (HP:0005736)	2.50347107
35	Polyuria (HP:0000103)	2.46216074
36	Cystic liver disease (HP:0006706)	2.33515984
37	Disproportionate short-trunk short stature (HP:0003521)	2.29712514
38	Genital tract atresia (HP:0001827)	2.28752105
39	3-Methylglutaconic aciduria (HP:0003535)	2.24849041
40	Bile duct proliferation (HP:0001408)	2.24582830
41	Abnormal biliary tract physiology (HP:0012439)	2.24582830
42	Decreased circulating renin level (HP:0003351)	2.24370272
43	Gaze-evoked nystagmus (HP:0000640)	2.23121691
44	Chronic hepatic failure (HP:0100626)	2.22617685
45	Bifid tongue (HP:0010297)	2.21444905
46	Dialeptic seizures (HP:0011146)	2.21035843
47	Epidermoid cyst (HP:0200040)	2.21016944
48	Spinal muscular atrophy (HP:0007269)	2.18541528
49	Gait imbalance (HP:0002141)	2.17122827
50	Pachygyria (HP:0001302)	2.16822437
51	Growth hormone deficiency (HP:0000824)	2.16506533
52	Optic nerve hypoplasia (HP:0000609)	2.15740939
53	Hemiparesis (HP:0001269)	2.13700684
54	Absent speech (HP:0001344)	2.11259044
55	Methylmalonic acidemia (HP:0002912)	2.10371437
56	Depressed nasal tip (HP:0000437)	2.09128579
57	Limb dystonia (HP:0002451)	2.07898512
58	Preaxial hand polydactyly (HP:0001177)	2.05226053
59	Postaxial foot polydactyly (HP:0001830)	2.03454834
60	Cupped ear (HP:0000378)	2.02434220
61	Occipital encephalocele (HP:0002085)	1.99911252
62	Amyotrophic lateral sclerosis (HP:0007354)	1.99874180
63	Fetal akinesia sequence (HP:0001989)	1.98067601
64	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96917789
65	Hip dysplasia (HP:0001385)	1.96202046
66	Vaginal atresia (HP:0000148)	1.95530330
67	Decreased central vision (HP:0007663)	1.95482886
68	Congenital hepatic fibrosis (HP:0002612)	1.93885485
69	Congenital primary aphakia (HP:0007707)	1.93731917
70	Abnormal urine output (HP:0012590)	1.93227186
71	Gastrointestinal atresia (HP:0002589)	1.91324880
72	Exertional dyspnea (HP:0002875)	1.90422485
73	Abnormality of the labia minora (HP:0012880)	1.89612328
74	Bilateral microphthalmos (HP:0007633)	1.87979228
75	Generalized tonic-clonic seizures (HP:0002069)	1.87306505
76	Absent/shortened dynein arms (HP:0200106)	1.86591711
77	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86591711
78	Anophthalmia (HP:0000528)	1.86316024
79	Neonatal respiratory distress (HP:0002643)	1.85713127
80	Increased hepatocellular lipid droplets (HP:0006565)	1.85580668
81	Hypoproteinemia (HP:0003075)	1.85442778
82	Postaxial hand polydactyly (HP:0001162)	1.85280950
83	Dandy-Walker malformation (HP:0001305)	1.85229762
84	Sclerocornea (HP:0000647)	1.85133754
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84841222
86	Lipid accumulation in hepatocytes (HP:0006561)	1.84171893
87	Absence seizures (HP:0002121)	1.83919929
88	Retinal atrophy (HP:0001105)	1.83706383
89	Median cleft lip (HP:0000161)	1.82881644
90	Abnormal ciliary motility (HP:0012262)	1.82204912
91	Hypoplastic iliac wings (HP:0002866)	1.81439787
92	Small hand (HP:0200055)	1.80111572
93	Calf muscle hypertrophy (HP:0008981)	1.76913511
94	Abnormality of homocysteine metabolism (HP:0010919)	1.75968363
95	Homocystinuria (HP:0002156)	1.75968363
96	Broad-based gait (HP:0002136)	1.75367944
97	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.74051675
98	Hypoplasia of the pons (HP:0012110)	1.73486890
99	Male pseudohermaphroditism (HP:0000037)	1.73168556
100	Epileptic encephalopathy (HP:0200134)	1.71010862

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.78230311
2	BMPR1B	3.36520748
3	VRK2	2.87402550
4	PNCK	2.72961467
5	MKNK2	2.60458962
6	MARK1	2.45270224
7	ACVR1B	2.38802346
8	ZAK	2.35091568
9	WNK3	2.26975396
10	ADRBK2	2.09604208
11	MUSK	2.01920961
12	MAPK13	2.01025404
13	TNIK	1.99772779
14	TAOK1	1.95050618
15	GRK1	1.94741598
16	VRK1	1.91063496
17	WEE1	1.87671919
18	CASK	1.82592044
19	TGFBR2	1.77115768
20	MAPKAPK5	1.76991073
21	TLK1	1.74139407
22	PDK2	1.69309709
23	IRAK1	1.65686540
24	ERBB4	1.50882102
25	NUAK1	1.47093107
26	MKNK1	1.44188749
27	PRKCG	1.43986471
28	TSSK6	1.36095147
29	PLK2	1.28034411
30	DYRK2	1.27613885
31	ERBB3	1.20790668
32	PRKCE	1.19773608
33	DYRK3	1.16639691
34	BRSK2	1.16037301
35	OXSR1	1.13348478
36	MAP3K4	1.12367183
37	SRPK1	1.09995741
38	PAK3	0.97336166
39	MAPKAPK3	0.94324421
40	ADRBK1	0.93844152
41	TRIM28	0.91402918
42	INSRR	0.90925687
43	NTRK2	0.88686264
44	MST4	0.87325600
45	EPHA3	0.86020293
46	CSNK1G2	0.85139358
47	PTK2B	0.84483307
48	MAP3K12	0.83941962
49	STK38L	0.82633968
50	PLK4	0.80688554
51	CDC7	0.79455824
52	PLK3	0.77781867
53	STK39	0.74774221
54	TGFBR1	0.73774116
55	BCKDK	0.72111960
56	CSNK1G3	0.71746776
57	MAP4K2	0.71003967
58	CDK3	0.70439406
59	MAPK15	0.70433287
60	CSNK1G1	0.67679172
61	STK11	0.66416887
62	PKN1	0.65901200
63	TXK	0.62510361
64	TAF1	0.57177608
65	CAMK1	0.57039011
66	EIF2AK2	0.56186863
67	DYRK1A	0.55846340
68	NME1	0.53817489
69	PRKCQ	0.50985758
70	CAMK2A	0.50525356
71	RPS6KA4	0.49556384
72	PINK1	0.49356038
73	TEC	0.48753992
74	EIF2AK3	0.47383346
75	GRK5	0.46703799
76	PRKACA	0.45978872
77	DAPK2	0.44916170
78	GRK7	0.43874057
79	TAOK3	0.42934216
80	CAMK1G	0.40390206
81	TIE1	0.39946059
82	NLK	0.39894178
83	PLK1	0.38596109
84	CAMKK2	0.36869207
85	NEK1	0.36750383
86	MAP3K7	0.36262601
87	BRSK1	0.35796308
88	CSNK1D	0.34646735
89	CCNB1	0.34598301
90	MAP2K7	0.33767456
91	YES1	0.31298284
92	CHEK2	0.30892813
93	PRKACB	0.30797300
94	PRKAA1	0.30508239
95	LATS1	0.30276548
96	SGK1	0.29244724
97	WNK4	0.28542439
98	MINK1	0.28230095
99	CAMK4	0.27982541
100	RPS6KA5	0.27865634

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.99259911
2	Butanoate metabolism_Homo sapiens_hsa00650	2.74068863
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.64754365
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.55677893
5	Sulfur relay system_Homo sapiens_hsa04122	2.35833755
6	Nicotine addiction_Homo sapiens_hsa05033	2.33919718
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.17402489
8	Phototransduction_Homo sapiens_hsa04744	2.16498690
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.11918509
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.08522087
11	Protein export_Homo sapiens_hsa03060	1.96810571
12	Homologous recombination_Homo sapiens_hsa03440	1.95108402
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.93764280
14	Olfactory transduction_Homo sapiens_hsa04740	1.89187972
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81591477
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.71157944
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.70865088
18	Propanoate metabolism_Homo sapiens_hsa00640	1.63049219
19	Basal transcription factors_Homo sapiens_hsa03022	1.62359209
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55800052
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.54600811
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.50888088
23	Caffeine metabolism_Homo sapiens_hsa00232	1.45668337
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45292591
25	RNA degradation_Homo sapiens_hsa03018	1.44267467
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38999360
27	RNA polymerase_Homo sapiens_hsa03020	1.37886622
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.29123432
29	Huntingtons disease_Homo sapiens_hsa05016	1.28972866
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.27502670
31	Taste transduction_Homo sapiens_hsa04742	1.24044801
32	Regulation of autophagy_Homo sapiens_hsa04140	1.21447365
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.21124009
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.20992223
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20019689
36	Circadian entrainment_Homo sapiens_hsa04713	1.16090407
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15205158
38	One carbon pool by folate_Homo sapiens_hsa00670	1.15025195
39	Proteasome_Homo sapiens_hsa03050	1.14688622
40	Circadian rhythm_Homo sapiens_hsa04710	1.13686111
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.13417072
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12236919
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.12112480
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10695516
45	Retinol metabolism_Homo sapiens_hsa00830	1.10648143
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09410302
47	Amphetamine addiction_Homo sapiens_hsa05031	1.07966846
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07050668
49	Parkinsons disease_Homo sapiens_hsa05012	1.03738444
50	GABAergic synapse_Homo sapiens_hsa04727	1.00766737
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.99608942
52	Serotonergic synapse_Homo sapiens_hsa04726	0.97312204
53	Morphine addiction_Homo sapiens_hsa05032	0.97100742
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.95765708
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.91620443
56	Insulin secretion_Homo sapiens_hsa04911	0.91291952
57	Peroxisome_Homo sapiens_hsa04146	0.88871827
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.83399926
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82608560
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.81805231
61	Fatty acid degradation_Homo sapiens_hsa00071	0.81718534
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80499851
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.80125901
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80047364
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.78267793
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.76648597
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73469345
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.73158743
69	Cocaine addiction_Homo sapiens_hsa05030	0.72970560
70	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.71147994
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70156394
72	ABC transporters_Homo sapiens_hsa02010	0.69559091
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.65643704
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64513236
75	Nucleotide excision repair_Homo sapiens_hsa03420	0.60377267
76	Histidine metabolism_Homo sapiens_hsa00340	0.60224131
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56840755
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56126267
79	Fatty acid elongation_Homo sapiens_hsa00062	0.55769320
80	Alzheimers disease_Homo sapiens_hsa05010	0.53793768
81	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.52592969
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52511656
83	Metabolic pathways_Homo sapiens_hsa01100	0.52109976
84	Purine metabolism_Homo sapiens_hsa00230	0.51113212
85	Lysine degradation_Homo sapiens_hsa00310	0.49894687
86	Asthma_Homo sapiens_hsa05310	0.49498939
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49432818
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47557837
89	Long-term depression_Homo sapiens_hsa04730	0.47436898
90	Mineral absorption_Homo sapiens_hsa04978	0.47150226
91	Mismatch repair_Homo sapiens_hsa03430	0.45890251
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43575608
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.40635319
94	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39024468
95	Oocyte meiosis_Homo sapiens_hsa04114	0.38893023
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38358481
97	Salivary secretion_Homo sapiens_hsa04970	0.37183917
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.33407275
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32681311
100	Renin secretion_Homo sapiens_hsa04924	0.32319856

ATP8A2P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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