ATP8B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of extracellular matrix disassembly (GO:0010715)4.15750265
2positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.96996525
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90060276
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60975949
5mannose metabolic process (GO:0006013)3.54429448
6protein heterotrimerization (GO:0070208)3.52387920
7blood vessel maturation (GO:0001955)3.50783444
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44443411
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.42365858
10positive regulation of gamma-delta T cell activation (GO:0046645)3.37095214
11negative regulation of erythrocyte differentiation (GO:0045647)3.36726629
12response to interleukin-15 (GO:0070672)3.33340299
13antigen processing and presentation of endogenous antigen (GO:0019883)3.28529112
14response to laminar fluid shear stress (GO:0034616)3.25162774
15leukocyte aggregation (GO:0070486)3.12445541
16regulation of histone H3-K27 methylation (GO:0061085)3.02010502
17collagen fibril organization (GO:0030199)2.93898053
18plasma membrane repair (GO:0001778)2.92719177
19embryonic process involved in female pregnancy (GO:0060136)2.90697595
20synaptic vesicle maturation (GO:0016188)2.88552752
21tolerance induction (GO:0002507)2.87783223
22stress fiber assembly (GO:0043149)2.87312331
23layer formation in cerebral cortex (GO:0021819)2.84692904
24establishment of nucleus localization (GO:0040023)2.82272826
25regulation of gamma-delta T cell differentiation (GO:0045586)2.80702032
26regulation of T cell tolerance induction (GO:0002664)2.80618040
27protein localization to endosome (GO:0036010)2.79289376
28cell migration involved in heart development (GO:0060973)2.77382631
29extracellular matrix assembly (GO:0085029)2.77269602
30locomotory exploration behavior (GO:0035641)2.76932316
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75781810
32positive regulation of fibroblast migration (GO:0010763)2.73768765
33peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.73401957
34response to fluid shear stress (GO:0034405)2.71329770
35T cell migration (GO:0072678)2.71158321
36antigen processing and presentation via MHC class Ib (GO:0002475)2.71040323
37basement membrane organization (GO:0071711)2.67230041
38positive regulation of granulocyte differentiation (GO:0030854)2.66858985
39positive regulation of histone deacetylation (GO:0031065)2.65727018
40insulin-like growth factor receptor signaling pathway (GO:0048009)2.64170523
41adherens junction assembly (GO:0034333)2.61953118
42negative regulation of fatty acid transport (GO:2000192)2.61433724
43pre-miRNA processing (GO:0031054)2.61413296
44regulation of short-term neuronal synaptic plasticity (GO:0048172)2.60515231
45activated T cell proliferation (GO:0050798)2.59046262
46positive regulation of tolerance induction (GO:0002645)2.55799764
47regulation of B cell receptor signaling pathway (GO:0050855)2.55449445
48cellular response to interleukin-15 (GO:0071350)2.52824195
49cytoplasmic mRNA processing body assembly (GO:0033962)2.51763863
50peptidyl-lysine dimethylation (GO:0018027)2.49193299
51negative regulation of cell killing (GO:0031342)2.48859941
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.48859941
53bone trabecula formation (GO:0060346)2.48563733
54positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48139069
55regulation of type I interferon-mediated signaling pathway (GO:0060338)2.47911813
56cortical actin cytoskeleton organization (GO:0030866)2.46243874
57sodium ion export (GO:0071436)2.45889862
58phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.45375668
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45086077
60thymic T cell selection (GO:0045061)2.44974473
61regulation of gamma-delta T cell activation (GO:0046643)2.43735070
62negative regulation of bone remodeling (GO:0046851)2.42877887
63venous blood vessel morphogenesis (GO:0048845)2.41668834
64chondroitin sulfate biosynthetic process (GO:0030206)2.40189667
65positive thymic T cell selection (GO:0045059)2.38807188
66negative regulation of T cell mediated immunity (GO:0002710)2.38793567
67regulation of defense response to virus by virus (GO:0050690)2.38020886
68positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35954447
69skin morphogenesis (GO:0043589)2.35602087
70Golgi transport vesicle coating (GO:0048200)2.34687206
71COPI coating of Golgi vesicle (GO:0048205)2.34687206
72hypotonic response (GO:0006971)2.34666855
73endodermal cell differentiation (GO:0035987)2.31953564
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.31648335
75positive regulation of receptor recycling (GO:0001921)2.31147921
76heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.29721144
77negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.28656144
78fibril organization (GO:0097435)2.27909579
79regulation of tolerance induction (GO:0002643)2.27669693
80synaptic vesicle docking involved in exocytosis (GO:0016081)2.27477953
81signal complex assembly (GO:0007172)2.26821745
82NLS-bearing protein import into nucleus (GO:0006607)2.24321116
83regulation of ARF GTPase activity (GO:0032312)2.22769776
84cell-substrate junction assembly (GO:0007044)2.22727869
85type B pancreatic cell proliferation (GO:0044342)2.22446714
86pericardium development (GO:0060039)2.21762820
87regulation of fibroblast migration (GO:0010762)2.21700161
88pathway-restricted SMAD protein phosphorylation (GO:0060389)2.21513148
89positive regulation of natural killer cell differentiation (GO:0032825)2.21333329
90positive regulation of epithelial to mesenchymal transition (GO:0010718)2.21331349
91heterochromatin organization (GO:0070828)2.21229483
92cell-substrate adherens junction assembly (GO:0007045)2.19600915
93focal adhesion assembly (GO:0048041)2.19600915
94positive T cell selection (GO:0043368)2.19487041
95activation of JUN kinase activity (GO:0007257)2.19368375
96gonadal mesoderm development (GO:0007506)2.19155322
97chondrocyte development (GO:0002063)2.19004614
98apoptotic cell clearance (GO:0043277)2.16965130
99positive regulation of Rap GTPase activity (GO:0032854)2.16784930
100negative regulation of skeletal muscle tissue development (GO:0048642)2.15715598
101peptidyl-threonine phosphorylation (GO:0018107)2.14615500
102regulation of extracellular matrix organization (GO:1903053)2.14567246
103T cell selection (GO:0045058)2.14338817
104negative regulation of phagocytosis (GO:0050765)2.14262117
105regulation of necroptotic process (GO:0060544)2.14010475
106negative T cell selection (GO:0043383)2.13694545
107negative thymic T cell selection (GO:0045060)2.13312964
108kidney mesenchyme development (GO:0072074)2.13264319
109neuron projection extension involved in neuron projection guidance (GO:1902284)2.13141411
110axon extension involved in axon guidance (GO:0048846)2.13141411
111glucocorticoid receptor signaling pathway (GO:0042921)2.13134580
112T cell receptor signaling pathway (GO:0050852)2.11695408
113peptidyl-threonine modification (GO:0018210)2.11668663
114vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.11595884
115negative regulation of catenin import into nucleus (GO:0035414)2.11330272
116activation of protein kinase A activity (GO:0034199)2.10649962
117cortical cytoskeleton organization (GO:0030865)2.10262175
118regulation of ARF protein signal transduction (GO:0032012)2.10225097
119histone H3-K9 demethylation (GO:0033169)2.09788469
120positive regulation of blood vessel endothelial cell migration (GO:0043536)2.09658617
121planar cell polarity pathway involved in neural tube closure (GO:0090179)2.08036249
122sequestering of extracellular ligand from receptor (GO:0035581)2.07926084
123regulation of Rap GTPase activity (GO:0032317)2.07490873
124chondrocyte proliferation (GO:0035988)2.06740027
125positive regulation of dendrite morphogenesis (GO:0050775)2.06514445
126polarized epithelial cell differentiation (GO:0030859)2.06150276
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.05653886
128histone H4-K16 acetylation (GO:0043984)2.04962308
129negative regulation of cell size (GO:0045792)2.02902221
130nuclear pore complex assembly (GO:0051292)2.01921885
131dendritic spine morphogenesis (GO:0060997)2.01913172
132regulation of tight junction assembly (GO:2000810)2.01517468
133body morphogenesis (GO:0010171)2.01329149
134G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.01034145
135regulation of clathrin-mediated endocytosis (GO:2000369)2.00886023
136neuromuscular process controlling balance (GO:0050885)1.99963649
137cell migration involved in sprouting angiogenesis (GO:0002042)1.99910673
138vascular endothelial growth factor signaling pathway (GO:0038084)1.97566334
139hippo signaling (GO:0035329)1.96611476
140vesicle transport along microtubule (GO:0047496)1.95322270
141glial cell proliferation (GO:0014009)1.95091469
142nerve growth factor signaling pathway (GO:0038180)1.94619826
143negative regulation of focal adhesion assembly (GO:0051895)1.94358937
144negative regulation of cell junction assembly (GO:1901889)1.94358937
145negative regulation of adherens junction organization (GO:1903392)1.94358937
146positive regulation of axon extension (GO:0045773)1.94219159
147regulation of NFAT protein import into nucleus (GO:0051532)1.94202192
148collagen metabolic process (GO:0032963)1.93764178
149natural killer cell differentiation (GO:0001779)1.93386064
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.93025592
151cell adhesion mediated by integrin (GO:0033627)1.92814274
152protein targeting to plasma membrane (GO:0072661)1.92320013
153collagen catabolic process (GO:0030574)1.92280832
154substrate-dependent cell migration (GO:0006929)1.90197228
155histone H4-K8 acetylation (GO:0043982)1.89862868
156histone H4-K5 acetylation (GO:0043981)1.89862868
157activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.88981260
158regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.88124675
159cellular potassium ion homeostasis (GO:0030007)1.87011769
160myoblast fusion (GO:0007520)1.85931354
161axon extension (GO:0048675)1.85132697
162regulation of synaptic vesicle exocytosis (GO:2000300)1.84746751
163histone H3-K36 demethylation (GO:0070544)1.84598617
164multicellular organismal macromolecule metabolic process (GO:0044259)1.84192684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.35604995
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.02678342
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.76268332
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.67722756
5* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.49258868
6WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.47654665
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45701250
8KDM2B_26808549_Chip-Seq_DND41_Human2.42400701
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38686350
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30218057
11MYC_22102868_ChIP-Seq_BL_Human2.27531958
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.26884160
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.23487174
14ZFP281_27345836_Chip-Seq_ESCs_Mouse2.15481611
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.13214983
16* KDM2B_26808549_Chip-Seq_K562_Human2.04906403
17* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01882379
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.00520174
19* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97680715
20* TCF7_22412390_ChIP-Seq_EML_Mouse1.94998483
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93428507
22* KDM2B_26808549_Chip-Seq_JURKAT_Human1.90810668
23* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.87914021
24DROSHA_22980978_ChIP-Seq_HELA_Human1.85822112
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83909145
26EZH2_22144423_ChIP-Seq_EOC_Human1.81018366
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.80583851
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75721411
29* MAF_26560356_Chip-Seq_TH2_Human1.75650469
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74770290
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74692636
32* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72599266
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71787552
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71110504
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.67464411
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66942028
37* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65825883
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65148878
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64265995
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.64183497
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.63042678
42VDR_24763502_ChIP-Seq_THP-1_Human1.62338189
43* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60346676
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59216077
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59216077
46* MYB_26560356_Chip-Seq_TH1_Human1.59061817
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54461728
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53999239
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52547385
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52379965
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48249513
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47494681
53MYB_26560356_Chip-Seq_TH2_Human1.46983147
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46030268
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44949774
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.43224927
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43163863
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41373082
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39625852
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.36630954
61* LXR_22292898_ChIP-Seq_THP-1_Human1.35795157
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30955367
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.29157542
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28164767
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26864734
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26634075
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26581419
68CLOCK_20551151_ChIP-Seq_293T_Human1.26469453
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24973893
70VDR_21846776_ChIP-Seq_THP-1_Human1.23464502
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22220614
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21143038
73* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20153487
74RUNX_20019798_ChIP-Seq_JUKART_Human1.19955717
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19651776
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19370234
77TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.19152998
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18891822
79TP53_16413492_ChIP-PET_HCT116_Human1.18504674
80RACK7_27058665_Chip-Seq_MCF-7_Human1.17383691
81* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17258045
82UTX_26944678_Chip-Seq_JUKART_Human1.16909533
83TP53_22127205_ChIP-Seq_IMR90_Human1.16189984
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15663536
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15298808
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15198708
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.15036276
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14854380
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.14450222
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13787555
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13268020
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12612845
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11906641
94* CREB1_26743006_Chip-Seq_LNCaP_Human1.09604839
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09471029
96* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09057560
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.08452773
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.07899823
99* MAF_26560356_Chip-Seq_TH1_Human1.07416569
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.07185738
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.06706317
102ISL1_27105846_Chip-Seq_CPCs_Mouse1.06090594
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05507116
104SCL_19346495_ChIP-Seq_HPC-7_Human1.05166737
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05036705
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04055948
107BRD4_25478319_ChIP-Seq_HGPS_Human1.03239585
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03020112
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.01600763
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00605043
111IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00364996
112* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99453978
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98847400
114PU_27001747_Chip-Seq_BMDM_Mouse0.98689777
115EZH2_27304074_Chip-Seq_ESCs_Mouse0.98533857
116* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98434647
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.97643712
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.97643712
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97604990
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97467269
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97342752
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96856470
123TP53_23651856_ChIP-Seq_MEFs_Mouse0.96554800
124AR_19668381_ChIP-Seq_PC3_Human0.96323150
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95771948
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.95739523
127SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95630346
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95542473
129* IRF8_27001747_Chip-Seq_BMDM_Mouse0.95134659
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94949794
131FOXM1_23109430_ChIP-Seq_U2OS_Human0.94406302
132SPI1_23127762_ChIP-Seq_K562_Human0.94223452
133* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94161827
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93430971
135* GATA1_19941826_ChIP-Seq_K562_Human0.93393737
136NCOR1_26117541_ChIP-Seq_K562_Human0.91943421
137AHR_22903824_ChIP-Seq_MCF-7_Human0.91663919
138NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90349801
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85664846
140GATA3_27048872_Chip-Seq_THYMUS_Human0.84873814
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84536961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.27866708
2MP0003705_abnormal_hypodermis_morpholog3.35009435
3MP0005623_abnormal_meninges_morphology3.14998196
4MP0003763_abnormal_thymus_physiology2.77561754
5MP0004859_abnormal_synaptic_plasticity2.69626066
6MP0005275_abnormal_skin_tensile2.65906089
7MP0005503_abnormal_tendon_morphology2.59190347
8MP0010352_gastrointestinal_tract_polyps2.27134326
9MP0003283_abnormal_digestive_organ2.16430810
10MP0003045_fibrosis2.13631400
11MP0003279_aneurysm2.12196281
12MP0004272_abnormal_basement_membrane2.01497226
13MP0005076_abnormal_cell_differentiation2.00429719
14MP0003436_decreased_susceptibility_to1.91658896
15MP0003300_gastrointestinal_ulcer1.91005407
16MP0003566_abnormal_cell_adhesion1.88503304
17MP0001958_emphysema1.88063471
18MP0002877_abnormal_melanocyte_morpholog1.87910292
19MP0003091_abnormal_cell_migration1.87557024
20MP0003122_maternal_imprinting1.80142301
21MP0008961_abnormal_basal_metabolism1.72311268
22MP0002396_abnormal_hematopoietic_system1.67603758
23MP0000569_abnormal_digit_pigmentation1.61754642
24MP0009780_abnormal_chondrocyte_physiolo1.58477448
25MP0004858_abnormal_nervous_system1.57063109
26MP0000013_abnormal_adipose_tissue1.56563286
27MP0010368_abnormal_lymphatic_system1.51568723
28MP0003172_abnormal_lysosome_physiology1.50244616
29MP0001542_abnormal_bone_strength1.48505912
30MP0010234_abnormal_vibrissa_follicle1.45913582
31MP0003123_paternal_imprinting1.41984394
32MP0000733_abnormal_muscle_development1.41860857
33MP0003787_abnormal_imprinting1.39236180
34MP0000751_myopathy1.36124755
35MP0009278_abnormal_bone_marrow1.34527014
36MP0000428_abnormal_craniofacial_morphol1.34527012
37MP0001348_abnormal_lacrimal_gland1.32532720
38MP0003635_abnormal_synaptic_transmissio1.30758332
39MP0003121_genomic_imprinting1.29463970
40MP0003385_abnormal_body_wall1.29395996
41MP0001533_abnormal_skeleton_physiology1.28643847
42MP0005390_skeleton_phenotype1.28221150
43MP0005023_abnormal_wound_healing1.28021910
44MP0005508_abnormal_skeleton_morphology1.26445330
45MP0003724_increased_susceptibility_to1.26028662
46MP0009333_abnormal_splenocyte_physiolog1.25594893
47MP0000685_abnormal_immune_system1.22372048
48MP0001299_abnormal_eye_distance/1.20377775
49MP0006054_spinal_hemorrhage1.20325518
50MP0002896_abnormal_bone_mineralization1.18219243
51MP0002254_reproductive_system_inflammat1.17606072
52MP0008260_abnormal_autophagy1.17477359
53MP0003303_peritoneal_inflammation1.17015146
54MP0004233_abnormal_muscle_weight1.13031818
55MP0001915_intracranial_hemorrhage1.11918430
56MP0002108_abnormal_muscle_morphology1.11800572
57MP0005171_absent_coat_pigmentation1.10668433
58MP0002909_abnormal_adrenal_gland1.09056739
59MP0000537_abnormal_urethra_morphology1.07802680
60MP0000858_altered_metastatic_potential1.06672045
61MP0005257_abnormal_intraocular_pressure1.05908820
62MP0004381_abnormal_hair_follicle1.05387351
63MP0000003_abnormal_adipose_tissue1.03805542
64MP0002398_abnormal_bone_marrow1.01851514
65MP0004947_skin_inflammation1.01341685
66MP0004510_myositis1.00799940
67MP0002405_respiratory_system_inflammati1.00740225
68MP0001800_abnormal_humoral_immune1.00488549
69MP0003115_abnormal_respiratory_system0.99937939
70MP0001835_abnormal_antigen_presentation0.99596593
71MP0002925_abnormal_cardiovascular_devel0.98536194
72MP0004197_abnormal_fetal_growth/weight/0.97509134
73MP0005409_darkened_coat_color0.97464104
74MP0001851_eye_inflammation0.97383937
75MP0002060_abnormal_skin_morphology0.97043509
76MP0002295_abnormal_pulmonary_circulatio0.96330207
77MP0004808_abnormal_hematopoietic_stem0.96058855
78MP0009384_cardiac_valve_regurgitation0.95778939
79MP0004084_abnormal_cardiac_muscle0.95744413
80MP0003828_pulmonary_edema0.94621584
81MP0000534_abnormal_ureter_morphology0.94432480
82MP0001849_ear_inflammation0.93964530
83MP0003935_abnormal_craniofacial_develop0.93760242
84MP0002420_abnormal_adaptive_immunity0.93186681
85MP0004134_abnormal_chest_morphology0.92512928
86MP0001819_abnormal_immune_cell0.92475373
87MP0005464_abnormal_platelet_physiology0.90725098
88MP0002063_abnormal_learning/memory/cond0.88495367
89MP0004185_abnormal_adipocyte_glucose0.87774947
90MP0001873_stomach_inflammation0.86924446
91MP0003795_abnormal_bone_structure0.85869101
92MP0005000_abnormal_immune_tolerance0.84856067
93MP0001614_abnormal_blood_vessel0.84458857
94MP0005621_abnormal_cell_physiology0.84292124
95MP0005595_abnormal_vascular_smooth0.83669108
96MP0002932_abnormal_joint_morphology0.83410033
97MP0002168_other_aberrant_phenotype0.82113731
98MP0002722_abnormal_immune_system0.82073100
99MP0001175_abnormal_lung_morphology0.81615039
100MP0002089_abnormal_postnatal_growth/wei0.81196065
101MP0000716_abnormal_immune_system0.81033947
102MP0010307_abnormal_tumor_latency0.80733912
103MP0002084_abnormal_developmental_patter0.80454667
104MP0004883_abnormal_blood_vessel0.80161457
105MP0003942_abnormal_urinary_system0.79614862
106MP0008569_lethality_at_weaning0.79499783
107MP0004811_abnormal_neuron_physiology0.79303302
108MP0002723_abnormal_immune_serum0.78735420
109MP0003448_altered_tumor_morphology0.77986436
110MP0002419_abnormal_innate_immunity0.77053948
111MP0000015_abnormal_ear_pigmentation0.76407019
112MP0005058_abnormal_lysosome_morphology0.76225112
113MP0008770_decreased_survivor_rate0.75899710
114MP0003119_abnormal_digestive_system0.75383499
115MP0002086_abnormal_extraembryonic_tissu0.75191955
116MP0005388_respiratory_system_phenotype0.74976136
117MP0002133_abnormal_respiratory_system0.74976136
118MP0003866_abnormal_defecation0.74837217
119MP0010030_abnormal_orbit_morphology0.74065479
120MP0002933_joint_inflammation0.73937882
121MP0001790_abnormal_immune_system0.73868611
122MP0005387_immune_system_phenotype0.73868611
123MP0005164_abnormal_response_to0.73332517
124MP0002116_abnormal_craniofacial_bone0.73180831
125MP0000767_abnormal_smooth_muscle0.72407616
126MP0004087_abnormal_muscle_fiber0.71781625
127MP0001243_abnormal_dermal_layer0.71296343
128MP0002114_abnormal_axial_skeleton0.70307034
129MP0003755_abnormal_palate_morphology0.69942842
130MP0002998_abnormal_bone_remodeling0.69031375
131MP0010630_abnormal_cardiac_muscle0.68307759
132MP0001784_abnormal_fluid_regulation0.67881545
133MP0009250_abnormal_appendicular_skeleto0.67510606
134MP0002115_abnormal_skeleton_extremities0.66790642
135MP0002234_abnormal_pharynx_morphology0.66307891
136MP0000432_abnormal_head_morphology0.65795872
137MP0009745_abnormal_behavioral_response0.63923719
138MP0004270_analgesia0.63632568
139MP0000703_abnormal_thymus_morphology0.63621502
140MP0000759_abnormal_skeletal_muscle0.62481800
141MP0002166_altered_tumor_susceptibility0.62361745
142MP0002128_abnormal_blood_circulation0.62274989
143MP0002572_abnormal_emotion/affect_behav0.61186988
144MP0004145_abnormal_muscle_electrophysio0.60006468
145MP0002282_abnormal_trachea_morphology0.59853944
146MP0002064_seizures0.59623199
147MP0002113_abnormal_skeleton_development0.59512373
148MP0000266_abnormal_heart_morphology0.59351372
149MP0002081_perinatal_lethality0.58541094

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.74541875
2Premature rupture of membranes (HP:0001788)4.07243044
3Cerebral aneurysm (HP:0004944)3.89492782
4Shallow orbits (HP:0000586)3.37507781
5Ankle contracture (HP:0006466)3.19958461
6Dilatation of the ascending aorta (HP:0005111)3.05461903
7Aortic dissection (HP:0002647)2.98942930
8Bladder diverticulum (HP:0000015)2.94619304
9Vertebral compression fractures (HP:0002953)2.94526414
10Biconcave vertebral bodies (HP:0004586)2.94112534
11Mitral valve prolapse (HP:0001634)2.89948986
12Genu recurvatum (HP:0002816)2.80974933
13Aortic aneurysm (HP:0004942)2.76092887
14Bowel diverticulosis (HP:0005222)2.73144133
15Broad metatarsal (HP:0001783)2.71128095
16Syringomyelia (HP:0003396)2.62467011
17Spinal cord lesions (HP:0100561)2.62467011
18Atrophic scars (HP:0001075)2.60047386
19Macroorchidism (HP:0000053)2.49658130
20Aortic regurgitation (HP:0001659)2.49623213
21Distal upper limb amyotrophy (HP:0007149)2.40594427
22Upper limb amyotrophy (HP:0009129)2.40594427
23Hyperacusis (HP:0010780)2.34997027
24Abnormality of oral frenula (HP:0000190)2.31565985
25Ulnar bowing (HP:0003031)2.29208946
26Obstructive sleep apnea (HP:0002870)2.25135672
27Spontaneous hematomas (HP:0007420)2.22525607
28Absent frontal sinuses (HP:0002688)2.22000033
29Buphthalmos (HP:0000557)2.20707895
30T lymphocytopenia (HP:0005403)2.17415558
31Fragile skin (HP:0001030)2.15931315
32Subacute progressive viral hepatitis (HP:0006572)2.15778750
33Delayed closure of the anterior fontanelle (HP:0001476)2.15659229
34Increased variability in muscle fiber diameter (HP:0003557)2.13317488
35Increased connective tissue (HP:0009025)2.11829122
36Peritonitis (HP:0002586)2.09285752
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08598391
38Short 4th metacarpal (HP:0010044)2.08598391
39Wide anterior fontanel (HP:0000260)2.08228614
40Hand muscle atrophy (HP:0009130)2.07844617
41Type 1 muscle fiber predominance (HP:0003803)2.07679342
42Aneurysm (HP:0002617)2.07564958
43Mildly elevated creatine phosphokinase (HP:0008180)2.07554612
44Abnormality of dentin (HP:0010299)2.06900031
45Wormian bones (HP:0002645)2.05695392
46Pointed chin (HP:0000307)2.05610218
47Soft skin (HP:0000977)2.04895371
48Aortic valve stenosis (HP:0001650)2.04725469
49Premature skin wrinkling (HP:0100678)2.04681325
50Abnormality of the lower motor neuron (HP:0002366)2.04533925
51Renal duplication (HP:0000075)2.03189651
52Cervical subluxation (HP:0003308)2.03028559
53Neonatal short-limb short stature (HP:0008921)2.02509632
54Broad face (HP:0000283)2.01829589
55Joint stiffness (HP:0001387)2.01506556
56Lower limb amyotrophy (HP:0007210)1.99915875
57Osteolytic defects of the phalanges of the hand (HP:0009771)1.99757769
58Osteolytic defects of the hand bones (HP:0009699)1.99757769
59Ankyloglossia (HP:0010296)1.99319003
60Increased density of long bones (HP:0006392)1.98407786
61Long eyelashes (HP:0000527)1.98212023
62Hypoventilation (HP:0002791)1.97840533
63Mitral regurgitation (HP:0001653)1.95226966
64Wrist flexion contracture (HP:0001239)1.92778474
65Spinal rigidity (HP:0003306)1.91775512
66Emphysema (HP:0002097)1.90873747
67Abnormality of T cell number (HP:0011839)1.89796538
68Vascular tortuosity (HP:0004948)1.89420690
69Distal lower limb amyotrophy (HP:0008944)1.89134356
70Striae distensae (HP:0001065)1.88822446
71Abnormality of skeletal muscle fiber size (HP:0012084)1.88264711
72Elbow flexion contracture (HP:0002987)1.87669655
73Slender build (HP:0001533)1.86936332
74Deviation of the hallux (HP:0010051)1.86190813
75Abnormality of the acetabulum (HP:0003170)1.85074647
76Hallux valgus (HP:0001822)1.85002348
77Arterial tortuosity (HP:0005116)1.83960487
78Hemiplegia (HP:0002301)1.81858887
79Hyperextensible skin (HP:0000974)1.81766193
80Eczematoid dermatitis (HP:0000976)1.81527175
81Camptodactyly of toe (HP:0001836)1.81520516
82Blue sclerae (HP:0000592)1.80987106
83Follicular hyperkeratosis (HP:0007502)1.80134974
84Nonimmune hydrops fetalis (HP:0001790)1.79075063
85Thin bony cortex (HP:0002753)1.78655784
86Overgrowth (HP:0001548)1.77904836
87Delayed cranial suture closure (HP:0000270)1.77310476
88Asymmetry of the thorax (HP:0001555)1.76807787
89Dislocated radial head (HP:0003083)1.76702100
90Ectopia lentis (HP:0001083)1.75626453
91Radial bowing (HP:0002986)1.74928769
92Flat cornea (HP:0007720)1.74891973
93Broad long bones (HP:0005622)1.74538474
94Neoplasm of the heart (HP:0100544)1.74406160
95Broad palm (HP:0001169)1.74336433
96Abnormality of skull ossification (HP:0002703)1.74272604
97Abnormality of the fingertips (HP:0001211)1.73783651
98Joint laxity (HP:0001388)1.73669590
99Long toe (HP:0010511)1.73051878
100Inguinal hernia (HP:0000023)1.72667586
101Rectal prolapse (HP:0002035)1.71874388
102Mitral stenosis (HP:0001718)1.71861338
103Broad thumb (HP:0011304)1.71706378
104Thoracolumbar scoliosis (HP:0002944)1.71651064
105Difficulty climbing stairs (HP:0003551)1.70370874
106Gastrointestinal infarctions (HP:0005244)1.69988359
107Abnormality of the astrocytes (HP:0100707)1.69662869
108Astrocytoma (HP:0009592)1.69662869
109Ovoid vertebral bodies (HP:0003300)1.69116642
110Vertebral arch anomaly (HP:0008438)1.68700957
111Resting tremor (HP:0002322)1.67499884
112Narrow palate (HP:0000189)1.67328826
113Congenital glaucoma (HP:0001087)1.66466000
114Annular pancreas (HP:0001734)1.66402885
115Mild short stature (HP:0003502)1.65884710
116Abnormality of the radial head (HP:0003995)1.65050284
117Broad ribs (HP:0000885)1.64690878
118Scapular winging (HP:0003691)1.64092803
119Bowing of the arm (HP:0006488)1.62728893
120Bowed forearm bones (HP:0003956)1.62728893
121Abnormal delayed hypersensitivity skin test (HP:0002963)1.61336282
122Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60735202
123Persistence of primary teeth (HP:0006335)1.60555776
124Focal seizures (HP:0007359)1.60264587
125Renovascular hypertension (HP:0100817)1.60134934
126Insomnia (HP:0100785)1.59310753
127Disproportionate tall stature (HP:0001519)1.58948373
128Joint contractures involving the joints of the feet (HP:0100492)1.58130188
129Flexion contracture of toe (HP:0005830)1.58130188
130Heterotopia (HP:0002282)1.57644905
131Enlarged penis (HP:0000040)1.57294851
132Hypoplasia of the iris (HP:0007676)1.56950605
133Mesomelia (HP:0003027)1.56886885
134Missing ribs (HP:0000921)1.55920126
135Broad phalanx (HP:0006009)1.55267517
136Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55178743
137Broad phalanges of the hand (HP:0009768)1.54575925
138Spondylolisthesis (HP:0003302)1.54555480
139Narrow nasal bridge (HP:0000446)1.54392734
140Abnormality of the 4th metacarpal (HP:0010012)1.53181497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.93488183
2TRIB33.81175458
3EEF2K2.94390039
4CDK122.92562623
5PDGFRA2.80554705
6PKN22.77864303
7TYRO32.75421740
8DDR22.70811799
9TTN2.41109873
10RIPK12.37879437
11MAP3K102.21262652
12SMG12.16170264
13MAP3K91.93390257
14SIK21.90539556
15PRKD31.87383183
16MAP2K31.85375207
17TYK21.83133728
18ICK1.73920648
19NTRK31.70218236
20ZAP701.62625702
21BMX1.60969797
22PRKCH1.60895136
23ALK1.59640104
24PAK61.48431874
25NTRK11.39665341
26DMPK1.35025085
27KSR21.32892611
28PDGFRB1.29552680
29SCYL21.25782875
30PRKD21.25098999
31PTK61.24341697
32ERN11.21422712
33MARK21.19431201
34WNK11.18059950
35LATS21.18008987
36FGFR31.17282560
37CAMK1G1.14905294
38LRRK21.13842747
39RET1.13435758
40CAMKK11.12566504
41PAK21.12200408
42TAOK11.11728865
43NTRK21.09182415
44MTOR1.08942673
45FGFR21.07253673
46NEK91.07076137
47PAK31.03555841
48CDC42BPA1.03028222
49PTK21.01882752
50TXK1.01074719
51EPHA41.00969320
52MAP4K11.00802966
53BTK0.99670473
54MYLK0.96900926
55FGFR10.95264218
56MELK0.95051933
57JAK10.92139013
58STK380.91143040
59SIK10.90775204
60TNK20.87519168
61MAP3K70.86590298
62NLK0.84827072
63MINK10.84807945
64ITK0.83739324
65MAP3K30.82995990
66PIK3CG0.81701546
67RPS6KL10.80697402
68RPS6KC10.80697402
69RIPK40.80582036
70STK100.80448460
71MAP3K140.78668773
72JAK30.76644452
73MAP3K60.76116178
74HIPK20.74602793
75LCK0.74249323
76PTK2B0.73857107
77KSR10.73778383
78MAPK120.73322526
79MAP3K40.72621088
80MAP3K20.72559544
81IKBKE0.72417422
82AKT30.71695938
83UHMK10.71098600
84GRK60.69738450
85FER0.68857751
86HCK0.68571795
87LATS10.66526992
88FES0.66361621
89STK110.65692311
90RPS6KA60.65618256
91DYRK1B0.65541749
92TEC0.63396116
93CDK40.63007336
94MAPK110.62910438
95FGFR40.62311100
96PAK40.62079935
97CAMK1D0.61719182
98CSK0.61145125
99CDK50.60904759
100PDPK10.59011420
101PRKD10.58708398
102MAP3K10.58342593
103DAPK20.57956696
104TAOK20.55715351
105TAOK30.53869150
106INSR0.53485009
107BRD40.53380613
108KIT0.53138491
109STK40.52994479
110TRPM70.52509135
111SIK30.50310567
112ROCK20.49064581
113EPHB10.48296111
114IRAK40.47560624
115MAP3K130.47435714
116ROCK10.46932893
117FLT30.46487357
118MAP2K20.46289142
119CAMKK20.45587543
120SGK20.45070512
121CDK60.44702319
122FYN0.44433798
123TBK10.44400139
124JAK20.44125832
125SGK30.44029278
126PNCK0.43955765
127TGFBR20.43641062
128MAPK100.42683665
129PRKG20.42588180
130MOS0.41749287
131SRC0.40597819
132MARK30.40449153
133FGR0.40372284
134PASK0.39423822
135CAMK40.38656201
136RPS6KA20.37800904
137PDK10.37516357
138CDK150.37407631
139MAPK80.36800501
140RAF10.35717365
141CDK90.35355431
142MAPK70.34008766

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045121.62361977
2Focal adhesion_Homo sapiens_hsa045101.55638268
3Long-term potentiation_Homo sapiens_hsa047201.49996716
4Glioma_Homo sapiens_hsa052141.39305642
5Other glycan degradation_Homo sapiens_hsa005111.37694837
6mTOR signaling pathway_Homo sapiens_hsa041501.35144603
7Proteoglycans in cancer_Homo sapiens_hsa052051.33862737
8Chronic myeloid leukemia_Homo sapiens_hsa052201.33520151
9Estrogen signaling pathway_Homo sapiens_hsa049151.29879461
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.29527864
11Dorso-ventral axis formation_Homo sapiens_hsa043201.28900828
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27371392
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25581528
14Dilated cardiomyopathy_Homo sapiens_hsa054141.24861026
15Hepatitis B_Homo sapiens_hsa051611.24513458
16Inositol phosphate metabolism_Homo sapiens_hsa005621.22741315
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21709512
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19702032
19Oxytocin signaling pathway_Homo sapiens_hsa049211.19041634
20Measles_Homo sapiens_hsa051621.18639198
21VEGF signaling pathway_Homo sapiens_hsa043701.17243725
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17018925
23Thyroid cancer_Homo sapiens_hsa052161.16095890
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.14931313
25Renin secretion_Homo sapiens_hsa049241.14924906
26Circadian entrainment_Homo sapiens_hsa047131.14683884
27GnRH signaling pathway_Homo sapiens_hsa049121.14545479
28Amphetamine addiction_Homo sapiens_hsa050311.13158506
29T cell receptor signaling pathway_Homo sapiens_hsa046601.12869430
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12217838
31Adherens junction_Homo sapiens_hsa045201.11474291
32Olfactory transduction_Homo sapiens_hsa047401.11399974
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11365431
34Colorectal cancer_Homo sapiens_hsa052101.10852715
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10754943
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09841089
37Gastric acid secretion_Homo sapiens_hsa049711.08960884
38Gap junction_Homo sapiens_hsa045401.07798745
39Primary immunodeficiency_Homo sapiens_hsa053401.07743158
40Endometrial cancer_Homo sapiens_hsa052131.06981861
41Dopaminergic synapse_Homo sapiens_hsa047281.05730306
42Axon guidance_Homo sapiens_hsa043601.05436111
43Non-small cell lung cancer_Homo sapiens_hsa052231.05293079
44Cholinergic synapse_Homo sapiens_hsa047251.04573592
45Malaria_Homo sapiens_hsa051441.04360334
46MicroRNAs in cancer_Homo sapiens_hsa052061.04133234
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03854672
48FoxO signaling pathway_Homo sapiens_hsa040681.03597805
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.03279117
50TNF signaling pathway_Homo sapiens_hsa046681.03073796
51Renal cell carcinoma_Homo sapiens_hsa052111.02382886
52Salivary secretion_Homo sapiens_hsa049701.02367606
53Amoebiasis_Homo sapiens_hsa051461.02088977
54ErbB signaling pathway_Homo sapiens_hsa040121.02025626
55Rap1 signaling pathway_Homo sapiens_hsa040151.01715418
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00971428
57Type II diabetes mellitus_Homo sapiens_hsa049301.00801116
58Platelet activation_Homo sapiens_hsa046111.00414428
59Glutamatergic synapse_Homo sapiens_hsa047240.99536436
60Melanoma_Homo sapiens_hsa052180.99185622
61Pancreatic cancer_Homo sapiens_hsa052120.98570611
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.97726470
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97412912
64Hippo signaling pathway_Homo sapiens_hsa043900.97344022
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97090178
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96847415
67Small cell lung cancer_Homo sapiens_hsa052220.96023086
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95925564
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94983181
70Insulin secretion_Homo sapiens_hsa049110.94749115
71MAPK signaling pathway_Homo sapiens_hsa040100.94622744
72Cocaine addiction_Homo sapiens_hsa050300.94565884
73Morphine addiction_Homo sapiens_hsa050320.94134781
74Long-term depression_Homo sapiens_hsa047300.93785248
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93118503
76Viral myocarditis_Homo sapiens_hsa054160.92036630
77Melanogenesis_Homo sapiens_hsa049160.91725852
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91559862
79B cell receptor signaling pathway_Homo sapiens_hsa046620.91182630
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90319265
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89646426
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.88824763
83Protein digestion and absorption_Homo sapiens_hsa049740.88378476
84cAMP signaling pathway_Homo sapiens_hsa040240.88160996
85Wnt signaling pathway_Homo sapiens_hsa043100.86353418
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.86345978
87GABAergic synapse_Homo sapiens_hsa047270.86122614
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.86089284
89Hepatitis C_Homo sapiens_hsa051600.85839013
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85551632
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84546404
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84024267
93Apoptosis_Homo sapiens_hsa042100.83706983
94Hedgehog signaling pathway_Homo sapiens_hsa043400.81905956
95TGF-beta signaling pathway_Homo sapiens_hsa043500.81692735
96HTLV-I infection_Homo sapiens_hsa051660.81520329
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81516841
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81282294
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.81246419
100Choline metabolism in cancer_Homo sapiens_hsa052310.80884525
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.80313659
102Bladder cancer_Homo sapiens_hsa052190.79459758
103Notch signaling pathway_Homo sapiens_hsa043300.79346708
104Nicotine addiction_Homo sapiens_hsa050330.79345698
105Endocytosis_Homo sapiens_hsa041440.79183847
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78707545
107Basal cell carcinoma_Homo sapiens_hsa052170.78694404
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78302135
109Insulin resistance_Homo sapiens_hsa049310.77565666
110Osteoclast differentiation_Homo sapiens_hsa043800.76601355
111Toxoplasmosis_Homo sapiens_hsa051450.76468426
112Viral carcinogenesis_Homo sapiens_hsa052030.76049930
113Synaptic vesicle cycle_Homo sapiens_hsa047210.75903881
114Acute myeloid leukemia_Homo sapiens_hsa052210.74759302
115Prolactin signaling pathway_Homo sapiens_hsa049170.73320188
116Chemokine signaling pathway_Homo sapiens_hsa040620.72598402
117Calcium signaling pathway_Homo sapiens_hsa040200.72513495
118Pathways in cancer_Homo sapiens_hsa052000.72328289
119Prostate cancer_Homo sapiens_hsa052150.71841680
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71499033
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70039294
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70035886
123Ras signaling pathway_Homo sapiens_hsa040140.69115861
124Insulin signaling pathway_Homo sapiens_hsa049100.68738138
125Shigellosis_Homo sapiens_hsa051310.64629196
126Influenza A_Homo sapiens_hsa051640.64220077
127HIF-1 signaling pathway_Homo sapiens_hsa040660.63690729
128Leishmaniasis_Homo sapiens_hsa051400.63203589
129Lysine degradation_Homo sapiens_hsa003100.61843933
130Prion diseases_Homo sapiens_hsa050200.56697491

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