ATP8B4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil mediated immunity (GO:0002446)6.90212465
2negative regulation of phagocytosis (GO:0050765)5.50801760
3disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.49905493
4killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.49905493
5myeloid leukocyte mediated immunity (GO:0002444)5.27932398
6negative regulation of erythrocyte differentiation (GO:0045647)5.02860015
7response to fungus (GO:0009620)4.93082894
8positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.90085257
9mature B cell differentiation involved in immune response (GO:0002313)4.79948869
10respiratory burst (GO:0045730)4.78434112
11modulation of growth of symbiont involved in interaction with host (GO:0044144)4.62779341
12regulation of growth of symbiont in host (GO:0044126)4.62779341
13negative regulation of growth of symbiont in host (GO:0044130)4.62779341
14negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.62779341
15leukocyte mediated cytotoxicity (GO:0001909)4.58037713
16neutrophil activation involved in immune response (GO:0002283)4.55659122
17mannose metabolic process (GO:0006013)4.48119909
18defense response to fungus (GO:0050832)4.46890713
19definitive hemopoiesis (GO:0060216)4.46203400
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26238541
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26238541
22positive regulation of granulocyte differentiation (GO:0030854)4.24662554
23cellular extravasation (GO:0045123)4.19658792
24leukocyte aggregation (GO:0070486)4.13102858
25Arp2/3 complex-mediated actin nucleation (GO:0034314)4.12010049
26regulation of gamma-delta T cell differentiation (GO:0045586)4.10126940
27killing of cells of other organism (GO:0031640)4.02534560
28disruption of cells of other organism (GO:0044364)4.02534560
29positive regulation of gamma-delta T cell activation (GO:0046645)4.00874713
30cellular response to zinc ion (GO:0071294)3.97780408
31mature B cell differentiation (GO:0002335)3.83341194
32response to peptidoglycan (GO:0032494)3.79747625
33regulation of B cell receptor signaling pathway (GO:0050855)3.79312579
34neutrophil activation (GO:0042119)3.72286571
35reactive oxygen species biosynthetic process (GO:1903409)3.69635398
36antigen processing and presentation of endogenous antigen (GO:0019883)3.63168776
37positive regulation of B cell differentiation (GO:0045579)3.62028428
38positive regulation by symbiont of host defense response (GO:0052509)3.58024809
39modulation by symbiont of host defense response (GO:0052031)3.58024809
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58024809
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58024809
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.58024809
43modulation by symbiont of host immune response (GO:0052553)3.58024809
44Peyers patch development (GO:0048541)3.56672671
45mucosal-associated lymphoid tissue development (GO:0048537)3.56672671
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.55522362
47negative regulation of cell killing (GO:0031342)3.55522362
48regulation of mast cell activation involved in immune response (GO:0033006)3.49567637
49positive regulation of mast cell degranulation (GO:0043306)3.49391542
50positive regulation of mast cell activation involved in immune response (GO:0033008)3.49391542
51pinocytosis (GO:0006907)3.44997809
52regulation of hypersensitivity (GO:0002883)3.42111320
53mast cell activation (GO:0045576)3.41382826
54granulocyte activation (GO:0036230)3.40921257
55microglial cell activation (GO:0001774)3.40325945
56regulation of granulocyte differentiation (GO:0030852)3.34516586
57regulation of interleukin-8 biosynthetic process (GO:0045414)3.33276954
58leukotriene metabolic process (GO:0006691)3.29321307
59actin nucleation (GO:0045010)3.27644652
60negative regulation of granulocyte differentiation (GO:0030853)3.24759168
61T cell migration (GO:0072678)3.23450576
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23355379
63negative regulation of interleukin-8 production (GO:0032717)3.22110574
64leukocyte degranulation (GO:0043299)3.19478366
65myeloid cell activation involved in immune response (GO:0002275)3.15646367
66response to muramyl dipeptide (GO:0032495)3.14561222
67cell killing (GO:0001906)3.14135068
68negative regulation of neurotransmitter secretion (GO:0046929)3.10714176
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.09383302
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05896744
71negative thymic T cell selection (GO:0045060)3.05653704
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05614295
73immunoglobulin mediated immune response (GO:0016064)3.05602999
74leukotriene biosynthetic process (GO:0019370)3.05585519
75negative regulation of interleukin-17 production (GO:0032700)3.05046597
76regulation of B cell differentiation (GO:0045577)3.03441550
77natural killer cell mediated cytotoxicity (GO:0042267)3.00747373
78natural killer cell mediated immunity (GO:0002228)3.00747373
79pentose-phosphate shunt (GO:0006098)3.00356866
80regulation of mast cell activation (GO:0033003)2.98801381
81positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.97724703
82positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.97369183
83leukocyte migration involved in inflammatory response (GO:0002523)2.96303486
84mast cell degranulation (GO:0043303)2.95113254
85mast cell activation involved in immune response (GO:0002279)2.95113254
86protein localization to kinetochore (GO:0034501)2.94073999
87phospholipid scrambling (GO:0017121)2.93990542
88positive T cell selection (GO:0043368)2.93841280
89macrophage activation (GO:0042116)2.93554567
90cellular response to ethanol (GO:0071361)2.93070489
91DNA unwinding involved in DNA replication (GO:0006268)2.91644423
92negative T cell selection (GO:0043383)2.90445081
93negative regulation of T cell mediated immunity (GO:0002710)2.89202545
94megakaryocyte development (GO:0035855)2.88344134
95DNA strand elongation involved in DNA replication (GO:0006271)2.88297200
96natural killer cell activation involved in immune response (GO:0002323)2.87536069
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86978453
98regulation of regulated secretory pathway (GO:1903305)2.86761970
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.86554267
100detection of other organism (GO:0098543)2.86181861
101superoxide anion generation (GO:0042554)2.84088338
102positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.82449753
103sequestering of metal ion (GO:0051238)2.81803188
104angiogenesis involved in wound healing (GO:0060055)2.80944932
105telomere maintenance via semi-conservative replication (GO:0032201)2.80140190
106ribosomal small subunit assembly (GO:0000028)2.79967652
107cellular response to exogenous dsRNA (GO:0071360)2.79894141
108DNA strand elongation (GO:0022616)2.79038378
109interkinetic nuclear migration (GO:0022027)2.78732111
110cell wall macromolecule catabolic process (GO:0016998)2.78447850
111negative regulation of interleukin-6 production (GO:0032715)2.77677162
112regulation of T-helper 1 cell differentiation (GO:0045625)2.76697550
113interferon-gamma production (GO:0032609)2.76145903
114positive regulation of mast cell activation (GO:0033005)2.74827267
115B cell receptor signaling pathway (GO:0050853)2.73702273
116NADPH regeneration (GO:0006740)2.73610272
117regulation of mast cell degranulation (GO:0043304)2.71413229
118leukocyte cell-cell adhesion (GO:0007159)2.71359667
119regulation of erythrocyte differentiation (GO:0045646)2.70006091
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.69574596
121detection of molecule of bacterial origin (GO:0032490)2.69554916
122regulation of interferon-beta biosynthetic process (GO:0045357)2.67864708
123positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.67808802
124negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66375000
125negative regulation of T-helper cell differentiation (GO:0045623)2.66375000
126response to protozoan (GO:0001562)2.66076342
127regulation of myeloid leukocyte mediated immunity (GO:0002886)2.65654463
128telomere maintenance via recombination (GO:0000722)2.64809411
129fucose catabolic process (GO:0019317)2.64549744
130L-fucose metabolic process (GO:0042354)2.64549744
131L-fucose catabolic process (GO:0042355)2.64549744
132positive regulation of leukocyte degranulation (GO:0043302)2.64192128
133regulation of germinal center formation (GO:0002634)2.62700395
134regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.61547682
135hepatocyte apoptotic process (GO:0097284)2.60427127
136production of molecular mediator involved in inflammatory response (GO:0002532)2.59271554
137regulation of leukocyte degranulation (GO:0043300)2.58527172
138protein localization to chromosome, centromeric region (GO:0071459)2.57705477
139positive thymic T cell selection (GO:0045059)2.55788856
140macrophage differentiation (GO:0030225)2.54977015
141regulation of gamma-delta T cell activation (GO:0046643)2.54599832
142response to host immune response (GO:0052572)2.54369032
143response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.54369032
144negative regulation of interleukin-12 production (GO:0032695)2.53564298
145defense response to protozoan (GO:0042832)2.53331809
146leukocyte mediated immunity (GO:0002443)2.53267563
147macrophage activation involved in immune response (GO:0002281)2.50544940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23023262
2MYB_21317192_ChIP-Seq_ERMYB_Mouse3.69151528
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.68858828
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.61702293
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46595274
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.29203619
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.23500244
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.14857916
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.00696185
10VDR_21846776_ChIP-Seq_THP-1_Human2.82300338
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78727760
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78555517
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72403521
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59487973
15SCL_19346495_ChIP-Seq_HPC-7_Human2.57017649
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52545493
17VDR_24787735_ChIP-Seq_THP-1_Human2.51638942
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50574915
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.49364219
20* SPI1_23547873_ChIP-Seq_NB4_Human2.46634040
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46626186
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30167560
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.30054944
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23540469
25MYC_22102868_ChIP-Seq_BL_Human2.15775948
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.13201594
27MYB_26560356_Chip-Seq_TH2_Human2.13141650
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12783175
29* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08752350
30* VDR_24763502_ChIP-Seq_THP-1_Human2.07196705
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06975541
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.05256392
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00069932
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99871170
35* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96418621
36* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94179735
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85529894
38MYB_26560356_Chip-Seq_TH1_Human1.81494297
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79858401
40MAF_26560356_Chip-Seq_TH1_Human1.74860546
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71687505
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71255901
43UTX_26944678_Chip-Seq_JUKART_Human1.68749283
44* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65964055
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61485858
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.60781369
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60714070
48* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59026363
49CIITA_25753668_ChIP-Seq_RAJI_Human1.57736299
50GATA1_22025678_ChIP-Seq_K562_Human1.57063184
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52687248
52SPI1_23127762_ChIP-Seq_K562_Human1.52105510
53GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.51623949
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50515430
55PU_27001747_Chip-Seq_BMDM_Mouse1.49850795
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48893485
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46027176
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45631697
59GATA1_19941826_ChIP-Seq_K562_Human1.43835979
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42278489
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42018477
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36155650
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35439931
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.35243109
65RUNX_20019798_ChIP-Seq_JUKART_Human1.34793386
66FOXP3_21729870_ChIP-Seq_TREG_Human1.33906286
67TCF7_22412390_ChIP-Seq_EML_Mouse1.33264937
68VDR_23849224_ChIP-Seq_CD4+_Human1.31935339
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31585902
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.30615375
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25982714
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23611681
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23369958
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23219415
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22918785
76GATA2_19941826_ChIP-Seq_K562_Human1.22033521
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21266342
78TFEB_21752829_ChIP-Seq_HELA_Human1.20993505
79GATA3_27048872_Chip-Seq_THYMUS_Human1.17261869
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15002696
81ELK1_19687146_ChIP-ChIP_HELA_Human1.14919046
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.12550450
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11939934
84* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10598650
85IGF1R_20145208_ChIP-Seq_DFB_Human1.09686907
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09007959
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08905502
88ETS1_22383799_ChIP-Seq_G1ME_Mouse1.07594215
89MAF_26560356_Chip-Seq_TH2_Human1.06611823
90KDM2B_26808549_Chip-Seq_DND41_Human1.05610737
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05144563
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05092450
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04659786
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04635301
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03805177
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03764978
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.00853884
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00683493
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.00079915
100* GATA3_26560356_Chip-Seq_TH2_Human0.98880295
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98736844
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97687777
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95714733
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94932789
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94352669
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93840863
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92980128
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92311332
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91064790
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90822023
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88669285
112KDM5A_27292631_Chip-Seq_BREAST_Human0.87462536
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87242686
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87223379
115XRN2_22483619_ChIP-Seq_HELA_Human0.87079775
116ETS1_20019798_ChIP-Seq_JURKAT_Human0.84668843
117CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84610688
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.84550129
119NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84232502
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83674185
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83319099
122SPI1_20517297_ChIP-Seq_HL60_Human0.79100150
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79048864
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78151260
125GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76080396
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71635458
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71250200
128NCOR1_26117541_ChIP-Seq_K562_Human0.68051537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.52694817
2MP0001835_abnormal_antigen_presentation3.38746730
3MP0003436_decreased_susceptibility_to3.19474126
4MP0002419_abnormal_innate_immunity2.98778130
5MP0003303_peritoneal_inflammation2.98568522
6MP0009785_altered_susceptibility_to2.84672568
7MP0000569_abnormal_digit_pigmentation2.71931367
8MP0003172_abnormal_lysosome_physiology2.67554806
9MP0005174_abnormal_tail_pigmentation2.66567875
10MP0005025_abnormal_response_to2.65229244
11MP0005464_abnormal_platelet_physiology2.59073331
12MP0003183_abnormal_peptide_metabolism2.52421375
13MP0005000_abnormal_immune_tolerance2.38825372
14MP0008057_abnormal_DNA_replication2.36815488
15MP0002148_abnormal_hypersensitivity_rea2.35743685
16MP0002420_abnormal_adaptive_immunity2.33924503
17MP0001819_abnormal_immune_cell2.32412540
18MP0005671_abnormal_response_to2.32012290
19MP0002166_altered_tumor_susceptibility2.31365305
20MP0002452_abnormal_antigen_presenting2.27665138
21MP0003828_pulmonary_edema2.23372526
22MP0001800_abnormal_humoral_immune2.22626433
23MP0003693_abnormal_embryo_hatching2.18282888
24MP0002723_abnormal_immune_serum2.15899132
25MP0004808_abnormal_hematopoietic_stem2.14229300
26MP0002398_abnormal_bone_marrow2.13574767
27MP0000685_abnormal_immune_system2.12178042
28MP0003763_abnormal_thymus_physiology2.06467089
29MP0005397_hematopoietic_system_phenotyp2.06011491
30MP0001545_abnormal_hematopoietic_system2.06011491
31MP0010094_abnormal_chromosome_stability2.04743163
32MP0010307_abnormal_tumor_latency1.98226682
33MP0002405_respiratory_system_inflammati1.96406937
34MP0002006_tumorigenesis1.94871275
35MP0000716_abnormal_immune_system1.93610845
36MP0003111_abnormal_nucleus_morphology1.92124032
37MP0005058_abnormal_lysosome_morphology1.89791921
38MP0001790_abnormal_immune_system1.88667042
39MP0005387_immune_system_phenotype1.88667042
40MP0009278_abnormal_bone_marrow1.81441655
41MP0003724_increased_susceptibility_to1.78982895
42MP0000858_altered_metastatic_potential1.77315491
43MP0000015_abnormal_ear_pigmentation1.76421827
44MP0002722_abnormal_immune_system1.74592231
45MP0003300_gastrointestinal_ulcer1.74590299
46MP0000689_abnormal_spleen_morphology1.72892597
47MP0008961_abnormal_basal_metabolism1.71049986
48MP0002429_abnormal_blood_cell1.70599853
49MP0000490_abnormal_crypts_of1.69911116
50MP0000465_gastrointestinal_hemorrhage1.66752383
51MP0001845_abnormal_inflammatory_respons1.66588783
52MP0009333_abnormal_splenocyte_physiolog1.65157591
53MP0010155_abnormal_intestine_physiology1.62828384
54MP0001533_abnormal_skeleton_physiology1.52408073
55MP0003077_abnormal_cell_cycle1.51387252
56MP0001853_heart_inflammation1.50151538
57MP0000703_abnormal_thymus_morphology1.48080945
58MP0005075_abnormal_melanosome_morpholog1.44726285
59MP0001873_stomach_inflammation1.42301061
60MP0006082_CNS_inflammation1.42006052
61MP0000343_altered_response_to1.33926219
62MP0002095_abnormal_skin_pigmentation1.29234342
63MP0003448_altered_tumor_morphology1.28880995
64MP0006054_spinal_hemorrhage1.27881044
65MP0008058_abnormal_DNA_repair1.25515045
66MP0001851_eye_inflammation1.24550185
67MP0002019_abnormal_tumor_incidence1.22374708
68MP0008469_abnormal_protein_level1.19908848
69MP0004947_skin_inflammation1.13399217
70MP0009765_abnormal_xenobiotic_induced1.12480224
71MP0003866_abnormal_defecation1.07968720
72MP0000371_diluted_coat_color1.04633493
73MP0004185_abnormal_adipocyte_glucose1.03683594
74MP0005076_abnormal_cell_differentiation1.02812336
75MP0003566_abnormal_cell_adhesion1.01873627
76MP0004957_abnormal_blastocyst_morpholog0.98097741
77MP0004883_abnormal_blood_vessel0.97998066
78MP0001986_abnormal_taste_sensitivity0.97715136
79MP0008007_abnormal_cellular_replicative0.93486480
80MP0002877_abnormal_melanocyte_morpholog0.93380777
81MP0004130_abnormal_muscle_cell0.93267750
82MP0005164_abnormal_response_to0.92569379
83MP0005666_abnormal_adipose_tissue0.92453867
84MP0010352_gastrointestinal_tract_polyps0.91673991
85MP0000313_abnormal_cell_death0.90932459
86MP0003656_abnormal_erythrocyte_physiolo0.89073263
87MP0003221_abnormal_cardiomyocyte_apopto0.88437511
88MP0005310_abnormal_salivary_gland0.85849349
89MP0009763_increased_sensitivity_to0.83684970
90MP0005390_skeleton_phenotype0.83501212
91MP0009764_decreased_sensitivity_to0.82280520
92MP0005166_decreased_susceptibility_to0.80569514
93MP0005167_abnormal_blood-brain_barrier0.79494699
94MP0005409_darkened_coat_color0.76411942
95MP0001663_abnormal_digestive_system0.76231154
96MP0003075_altered_response_to0.73707701
97MP0002933_joint_inflammation0.73590006
98MP0000681_abnormal_thyroid_gland0.72300093
99MP0000350_abnormal_cell_proliferation0.68854614
100MP0008877_abnormal_DNA_methylation0.68654860
101MP0004147_increased_porphyrin_level0.67925500
102MP0005621_abnormal_cell_physiology0.67706129
103MP0002998_abnormal_bone_remodeling0.67617407
104MP0003795_abnormal_bone_structure0.66857000
105MP0009115_abnormal_fat_cell0.66742078
106MP0003191_abnormal_cellular_cholesterol0.66023024
107MP0008873_increased_physiological_sensi0.65516220
108MP0000604_amyloidosis0.63781148
109MP0004510_myositis0.62010937
110MP0004484_altered_response_of0.61931636
111MP0002009_preneoplasia0.61680573
112MP0005165_increased_susceptibility_to0.60528292
113MP0003806_abnormal_nucleotide_metabolis0.60308168
114MP0004782_abnormal_surfactant_physiolog0.59810380
115MP0000249_abnormal_blood_vessel0.59367473
116MP0009840_abnormal_foam_cell0.58735379
117MP0005384_cellular_phenotype0.58528448
118MP0005334_abnormal_fat_pad0.58094439
119MP0001915_intracranial_hemorrhage0.57572000
120MP0002075_abnormal_coat/hair_pigmentati0.57405895
121MP0005647_abnormal_sex_gland0.57374291
122MP0004264_abnormal_extraembryonic_tissu0.55640768
123MP0005319_abnormal_enzyme/_coenzyme0.54371847
124MP0005535_abnormal_body_temperature0.54073067

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.36691615
2Eczematoid dermatitis (HP:0000976)6.05084438
3Recurrent bacterial skin infections (HP:0005406)5.88057753
4Thrombocytosis (HP:0001894)5.33393039
5Obstructive lung disease (HP:0006536)4.77280375
6Chronic obstructive pulmonary disease (HP:0006510)4.77280375
7Myositis (HP:0100614)4.47741010
8Recurrent gram-negative bacterial infections (HP:0005420)4.30750259
9Elevated erythrocyte sedimentation rate (HP:0003565)4.26336687
10Abnormality of liposaccharide metabolism (HP:0010968)4.03276144
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.03276144
12Abnormality of glycolipid metabolism (HP:0010969)4.03276144
13Recurrent fungal infections (HP:0002841)3.98067839
14Periodontitis (HP:0000704)3.82284724
15Recurrent skin infections (HP:0001581)3.77770478
16Mediastinal lymphadenopathy (HP:0100721)3.69761888
17Abnormality of macrophages (HP:0004311)3.64946646
18Abnormality of the prostate (HP:0008775)3.57100960
19Meningitis (HP:0001287)3.53597688
20Recurrent viral infections (HP:0004429)3.42617676
21Dysostosis multiplex (HP:0000943)3.35164365
22Gingivitis (HP:0000230)3.28684674
23Orchitis (HP:0100796)3.24708358
24IgM deficiency (HP:0002850)3.22307811
25Eosinophilia (HP:0001880)3.20807442
26Autoimmune hemolytic anemia (HP:0001890)3.16620834
27Chest pain (HP:0100749)3.14300754
28Papilledema (HP:0001085)3.13864342
29Chronic otitis media (HP:0000389)3.12076266
30Optic neuritis (HP:0100653)3.05787417
31Retrobulbar optic neuritis (HP:0100654)3.05787417
32Agammaglobulinemia (HP:0004432)3.05163671
33Vacuolated lymphocytes (HP:0001922)3.03555028
34Colitis (HP:0002583)3.00916199
35Granulocytopenia (HP:0001913)2.97424476
36Chronic mucocutaneous candidiasis (HP:0002728)2.92755772
37Recurrent cutaneous fungal infections (HP:0011370)2.92755772
38Vasculitis (HP:0002633)2.89208149
39Hemoptysis (HP:0002105)2.81960747
40Leukocytosis (HP:0001974)2.80793736
41Cellulitis (HP:0100658)2.77111678
42Stomatitis (HP:0010280)2.76325790
43Petechiae (HP:0000967)2.75183190
44Chromsome breakage (HP:0040012)2.73665463
45Spontaneous hematomas (HP:0007420)2.67862167
46B lymphocytopenia (HP:0010976)2.67573197
47Abnormality of B cell number (HP:0010975)2.67573197
48Pulmonary infiltrates (HP:0002113)2.64498584
49Agnosia (HP:0010524)2.60860723
50Abnormality of T cell physiology (HP:0011840)2.60065872
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.58458773
52Inflammation of the large intestine (HP:0002037)2.58116877
53Abnormality of eosinophils (HP:0001879)2.57787602
54Osteomyelitis (HP:0002754)2.56708647
55Epistaxis (HP:0000421)2.56016852
56Impaired platelet aggregation (HP:0003540)2.53144297
57Abnormal platelet function (HP:0011869)2.53144297
58Spondylolisthesis (HP:0003302)2.49277813
59Arterial thrombosis (HP:0004420)2.47896152
60Keratoconjunctivitis sicca (HP:0001097)2.45870774
61Abnormality of T cells (HP:0002843)2.43872137
62Poikiloderma (HP:0001029)2.40947328
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40498747
64Abnormality of polysaccharide metabolism (HP:0011012)2.40498747
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40498747
66Gastrointestinal inflammation (HP:0004386)2.38578937
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37440239
68Urticaria (HP:0001025)2.37133764
69Prolonged bleeding time (HP:0003010)2.36634695
70Mucopolysacchariduria (HP:0008155)2.36528720
71Urinary glycosaminoglycan excretion (HP:0003541)2.36528720
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34779945
73Abnormality of the pleura (HP:0002103)2.34613224
74Amyloidosis (HP:0011034)2.32578421
75Loss of speech (HP:0002371)2.31825590
76Prostate neoplasm (HP:0100787)2.30626546
77Increased IgE level (HP:0003212)2.30486211
78Acute myeloid leukemia (HP:0004808)2.28791494
79Keratoconjunctivitis (HP:0001096)2.28267805
80Widely spaced teeth (HP:0000687)2.26394827
81Abnormality of the fingertips (HP:0001211)2.26084568
82Pulmonary embolism (HP:0002204)2.25731511
83Cutaneous melanoma (HP:0012056)2.25082054
84Gangrene (HP:0100758)2.22244226
85Encephalitis (HP:0002383)2.22235602
86Myelodysplasia (HP:0002863)2.22230100
87Pustule (HP:0200039)2.20014125
88Reticulocytopenia (HP:0001896)2.18499854
89Skin ulcer (HP:0200042)2.18358431
90T lymphocytopenia (HP:0005403)2.17198755
91Systemic lupus erythematosus (HP:0002725)2.16547237
92Amaurosis fugax (HP:0100576)2.16155986
93Interstitial pulmonary disease (HP:0006530)2.15856127
94Abnormality of iron homeostasis (HP:0011031)2.15616298
95Hypergammaglobulinemia (HP:0010702)2.15153253
96Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14856480
97Pulmonary fibrosis (HP:0002206)2.13921425
98Severe combined immunodeficiency (HP:0004430)2.11320809
99Abnormality of the thoracic spine (HP:0100711)2.11028627
100Gingival bleeding (HP:0000225)2.10312753
101Abnormal platelet volume (HP:0011876)2.07648122
102Recurrent pneumonia (HP:0006532)2.07123811
103Abnormality of DNA repair (HP:0003254)2.06772594
104Viral hepatitis (HP:0006562)2.06349527
105Increased neuronal autofluorescent lipopigment (HP:0002074)2.06077363
106Increased cerebral lipofuscin (HP:0011813)2.04790600
107Abnormality of T cell number (HP:0011839)2.04617746
108Thrombophlebitis (HP:0004418)2.03581515
109Sepsis (HP:0100806)2.03440904
110Gastrointestinal infarctions (HP:0005244)2.03301157
111Entropion (HP:0000621)2.03293891
112J-shaped sella turcica (HP:0002680)2.01469319
113Panhypogammaglobulinemia (HP:0003139)2.01004882
114Thoracic kyphosis (HP:0002942)2.00712402
115Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00570594
116Acute lymphatic leukemia (HP:0006721)1.98940904
117Glomerulopathy (HP:0100820)1.98820362
118Recurrent bronchitis (HP:0002837)1.98432505
119Hypochromic microcytic anemia (HP:0004840)1.98081616
120Fatigue (HP:0012378)1.97348717
121Lymphoma (HP:0002665)1.96924453
122Autoimmune thrombocytopenia (HP:0001973)1.96821011
123Albinism (HP:0001022)1.96651981
124Abnormality of cells of the lymphoid lineage (HP:0012140)1.95732370
125Hepatosplenomegaly (HP:0001433)1.95407935
126Lymphopenia (HP:0001888)1.94274922
127Thyroiditis (HP:0100646)1.94183870
128Basal ganglia calcification (HP:0002135)1.92915004
129Disinhibition (HP:0000734)1.92002994
130Cheilitis (HP:0100825)1.90546441
131Joint hemorrhage (HP:0005261)1.90021311
132Neutropenia (HP:0001875)1.89797683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.16050511
2IRAK43.93584542
3TAOK33.54499967
4MAP4K13.13999840
5TEC2.46170012
6KIT2.40273588
7BLK2.34269902
8BTK2.28415307
9STK102.20257045
10TXK2.10200407
11EEF2K2.10158363
12MAP3K142.06462889
13TGFBR21.99257913
14BMPR21.97607355
15FES1.95054556
16ZAP701.92415801
17FLT31.84346098
18PRPF4B1.83216063
19CDC71.81129373
20PKN21.79348559
21RIPK41.76749357
22ITK1.71396429
23TYK21.69926160
24MAP2K31.61304769
25PIM21.56886961
26JAK31.55797964
27SYK1.54931601
28PIK3CG1.54453146
29CLK11.48856841
30GRK71.45521316
31TRPM71.40796911
32IRAK31.38474581
33GRK61.31734382
34BRSK21.30707776
35WEE11.28183337
36TBK11.27506884
37IKBKE1.26581699
38NEK21.21626431
39HCK1.19644191
40LRRK21.19516688
41ATR1.18220525
42TESK21.15519284
43MAP3K121.15242353
44EPHB11.15202087
45PIM11.15169675
46SRPK11.14755740
47CSF1R1.12087443
48CSK1.09748163
49ERN11.09309605
50LCK1.03562536
51STK41.02035352
52IRAK11.01329495
53JAK11.00326655
54MOS0.99238623
55EIF2AK20.98041054
56PLK40.97568546
57SIK20.97258698
58MAP3K80.96946078
59STK240.96718080
60LYN0.95690551
61PIK3CA0.95507992
62TESK10.92761478
63RPS6KA40.91996909
64MAP3K60.89762275
65NUAK10.89436046
66ACVR1B0.89069345
67MAP3K100.88791081
68STK160.88210136
69ERBB30.87567771
70RPS6KC10.86409138
71RPS6KL10.86409138
72RPS6KA60.85406694
73TTN0.83149196
74RPS6KB20.81323087
75CHUK0.79906244
76RPS6KA20.78855195
77CDK40.78347497
78MAP3K10.76373104
79SCYL20.74652743
80MAP3K50.73638360
81PAK40.73574253
82IKBKB0.73534995
83IRAK20.72945752
84BRD40.72369479
85ABL10.72173050
86MAPK40.71890901
87NEK90.71012006
88DAPK10.67103325
89MARK30.64987082
90EIF2AK30.63603067
91JAK20.63368202
92MAP3K130.63066262
93MAP2K20.61692058
94CDK70.61358518
95FRK0.59002943
96CDK120.58219702
97CDK60.56896053
98PDK10.56184899
99VRK10.54894293
100MKNK10.50896008
101MAP3K110.50187382
102PTK60.49997806
103ABL20.49613910
104AURKB0.49520107
105BUB10.48620480
106TNK20.47371336
107TSSK60.46311325
108MATK0.46166484
109PRKCQ0.45693483
110MAPK30.44781582
111FGFR30.44553372
112TLK10.44518787
113MAPK70.43772369
114NME20.42742302
115HIPK20.42662121
116ALK0.42087793
117TGFBR10.41890535
118PASK0.41116242
119PLK10.41041534
120MAPK150.40878704
121MAPKAPK20.40729772
122RIPK10.40534600
123PRKCD0.40355099
124TRIB30.39639546
125RET0.39014831
126BRSK10.38266785
127MAP2K60.37813736
128TAOK20.36528716
129MAPK120.35021456
130MKNK20.34587060
131MAPK110.34515609
132CAMK1D0.34188545
133EPHA30.30027272
134IGF1R0.29301177
135FYN0.29103569
136PDPK10.28905975
137PRKD20.28238906
138CDK30.27753513
139CAMKK20.26857151

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.33745374
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.89844991
3Leishmaniasis_Homo sapiens_hsa051402.82118420
4Mismatch repair_Homo sapiens_hsa034302.07213239
5Autoimmune thyroid disease_Homo sapiens_hsa053202.06459020
6Antigen processing and presentation_Homo sapiens_hsa046122.05168984
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02229906
8Homologous recombination_Homo sapiens_hsa034402.01360507
9Base excision repair_Homo sapiens_hsa034101.96055751
10Osteoclast differentiation_Homo sapiens_hsa043801.96048577
11Measles_Homo sapiens_hsa051621.86282247
12Primary immunodeficiency_Homo sapiens_hsa053401.82796794
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80343745
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77578558
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.77416064
16Other glycan degradation_Homo sapiens_hsa005111.75368173
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71569443
18Non-homologous end-joining_Homo sapiens_hsa034501.70816892
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.70692084
20Legionellosis_Homo sapiens_hsa051341.67398857
21B cell receptor signaling pathway_Homo sapiens_hsa046621.67037295
22Type I diabetes mellitus_Homo sapiens_hsa049401.61581814
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60525021
24Rheumatoid arthritis_Homo sapiens_hsa053231.59789940
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.59619868
26Herpes simplex infection_Homo sapiens_hsa051681.58080480
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54742974
28Tuberculosis_Homo sapiens_hsa051521.50905246
29Asthma_Homo sapiens_hsa053101.50196038
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49080939
31Pertussis_Homo sapiens_hsa051331.44518218
32Fanconi anemia pathway_Homo sapiens_hsa034601.41999868
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41969671
34Cell cycle_Homo sapiens_hsa041101.41570235
35One carbon pool by folate_Homo sapiens_hsa006701.38753695
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37964286
37Pentose phosphate pathway_Homo sapiens_hsa000301.37159347
38Apoptosis_Homo sapiens_hsa042101.35167105
39Influenza A_Homo sapiens_hsa051641.31149764
40Hematopoietic cell lineage_Homo sapiens_hsa046401.30496267
41Phagosome_Homo sapiens_hsa041451.27450470
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.26010350
43Lysosome_Homo sapiens_hsa041421.25791893
44Shigellosis_Homo sapiens_hsa051311.19937016
45Toxoplasmosis_Homo sapiens_hsa051451.19214487
46Hepatitis B_Homo sapiens_hsa051611.17178813
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15979659
48N-Glycan biosynthesis_Homo sapiens_hsa005101.12292443
49Spliceosome_Homo sapiens_hsa030401.11171508
50Staphylococcus aureus infection_Homo sapiens_hsa051501.10576216
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09278924
52Nucleotide excision repair_Homo sapiens_hsa034201.07960065
53African trypanosomiasis_Homo sapiens_hsa051431.07474546
54Chemokine signaling pathway_Homo sapiens_hsa040621.05448601
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.03110107
56T cell receptor signaling pathway_Homo sapiens_hsa046601.02788547
57Chronic myeloid leukemia_Homo sapiens_hsa052201.02410234
58Graft-versus-host disease_Homo sapiens_hsa053320.99902988
59Viral myocarditis_Homo sapiens_hsa054160.99568838
60Allograft rejection_Homo sapiens_hsa053300.98946548
61Acute myeloid leukemia_Homo sapiens_hsa052210.96689300
62Epstein-Barr virus infection_Homo sapiens_hsa051690.94372717
63Renin-angiotensin system_Homo sapiens_hsa046140.92601193
64TNF signaling pathway_Homo sapiens_hsa046680.92554494
65Viral carcinogenesis_Homo sapiens_hsa052030.91696291
66Malaria_Homo sapiens_hsa051440.90684203
67Salmonella infection_Homo sapiens_hsa051320.90344031
68Ribosome_Homo sapiens_hsa030100.90312011
69Pancreatic cancer_Homo sapiens_hsa052120.84511070
70Dorso-ventral axis formation_Homo sapiens_hsa043200.84440810
71Prolactin signaling pathway_Homo sapiens_hsa049170.82915398
72RNA transport_Homo sapiens_hsa030130.82647883
73p53 signaling pathway_Homo sapiens_hsa041150.80695764
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.80609011
75Hepatitis C_Homo sapiens_hsa051600.79844893
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79713770
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79161653
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78846714
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76971343
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76564291
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75009980
82Pyrimidine metabolism_Homo sapiens_hsa002400.74789393
83Platelet activation_Homo sapiens_hsa046110.74573957
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74466109
85RNA degradation_Homo sapiens_hsa030180.72346104
86Non-small cell lung cancer_Homo sapiens_hsa052230.71263441
87Amoebiasis_Homo sapiens_hsa051460.70202442
88Systemic lupus erythematosus_Homo sapiens_hsa053220.70051153
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68547415
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65043222
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64733257
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.63884059
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61564398
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60359063
95HTLV-I infection_Homo sapiens_hsa051660.59993776
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59698301
97Galactose metabolism_Homo sapiens_hsa000520.59032104
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58796782
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57320472
100Protein export_Homo sapiens_hsa030600.57265076
101Small cell lung cancer_Homo sapiens_hsa052220.53692988
102mTOR signaling pathway_Homo sapiens_hsa041500.50141426
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49400300
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.48016150
105VEGF signaling pathway_Homo sapiens_hsa043700.46216627
106mRNA surveillance pathway_Homo sapiens_hsa030150.45131688
107GnRH signaling pathway_Homo sapiens_hsa049120.44945588
108Insulin resistance_Homo sapiens_hsa049310.44283628
109Caffeine metabolism_Homo sapiens_hsa002320.43676049
110RNA polymerase_Homo sapiens_hsa030200.42035966
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41971728
112Inositol phosphate metabolism_Homo sapiens_hsa005620.40992477
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.38881028
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.38505390
115Renin secretion_Homo sapiens_hsa049240.38202585
116Choline metabolism in cancer_Homo sapiens_hsa052310.38017003
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38015931
118Salivary secretion_Homo sapiens_hsa049700.37423938
119Starch and sucrose metabolism_Homo sapiens_hsa005000.36979872
120Lysine degradation_Homo sapiens_hsa003100.35779401
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34765790
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34678462
123HIF-1 signaling pathway_Homo sapiens_hsa040660.34650525
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34547883
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33418893
126MAPK signaling pathway_Homo sapiens_hsa040100.33280037
127FoxO signaling pathway_Homo sapiens_hsa040680.32651047
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31781054
129Ether lipid metabolism_Homo sapiens_hsa005650.30891380
130Regulation of autophagy_Homo sapiens_hsa041400.30050548
131Type II diabetes mellitus_Homo sapiens_hsa049300.28660998
132Glioma_Homo sapiens_hsa052140.24622726
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23412290
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21796201
135Complement and coagulation cascades_Homo sapiens_hsa046100.19311060

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