ATP9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.63822889
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.50449644
3locomotory exploration behavior (GO:0035641)5.25887893
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14694575
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.79973281
6vocalization behavior (GO:0071625)4.79370841
7layer formation in cerebral cortex (GO:0021819)4.55263897
8glutamate secretion (GO:0014047)4.53341836
9synaptic vesicle exocytosis (GO:0016079)4.50556475
10regulation of synaptic vesicle exocytosis (GO:2000300)4.44330245
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40241250
12regulation of glutamate receptor signaling pathway (GO:1900449)4.12313387
13protein localization to synapse (GO:0035418)4.10904636
14exploration behavior (GO:0035640)4.10489787
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.04487565
16neurotransmitter secretion (GO:0007269)4.01922649
17regulation of synapse structural plasticity (GO:0051823)4.00654982
18neuron cell-cell adhesion (GO:0007158)3.97890343
19regulation of synaptic vesicle transport (GO:1902803)3.92123024
20gamma-aminobutyric acid transport (GO:0015812)3.89603832
21dendritic spine morphogenesis (GO:0060997)3.88828217
22regulation of neuronal synaptic plasticity (GO:0048168)3.87798302
23proline transport (GO:0015824)3.84540156
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.78948749
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77061558
26presynaptic membrane assembly (GO:0097105)3.72482497
27activation of protein kinase A activity (GO:0034199)3.66503111
28neuronal action potential propagation (GO:0019227)3.63583501
29cellular potassium ion homeostasis (GO:0030007)3.55945240
30sodium ion export (GO:0071436)3.53387027
31neurotransmitter-gated ion channel clustering (GO:0072578)3.52678225
32presynaptic membrane organization (GO:0097090)3.52169306
33glycine transport (GO:0015816)3.49819500
34synaptic transmission, glutamatergic (GO:0035249)3.43195879
35neuromuscular process controlling balance (GO:0050885)3.35800335
36dendrite morphogenesis (GO:0048813)3.35247240
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32646851
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32469981
39neuron recognition (GO:0008038)3.32392722
40glutamate receptor signaling pathway (GO:0007215)3.30142428
41L-amino acid import (GO:0043092)3.27270118
42neurotransmitter transport (GO:0006836)3.25793229
43long-term memory (GO:0007616)3.23125415
44neuron-neuron synaptic transmission (GO:0007270)3.22063118
45positive regulation of membrane potential (GO:0045838)3.18348049
46cell communication by electrical coupling (GO:0010644)3.17538005
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17073386
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.16966619
49startle response (GO:0001964)3.12554741
50auditory behavior (GO:0031223)3.11167488
51positive regulation of synapse maturation (GO:0090129)3.10979290
52regulation of dendritic spine morphogenesis (GO:0061001)3.10069729
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09220214
54axonal fasciculation (GO:0007413)3.08257986
55transmission of nerve impulse (GO:0019226)3.07977007
56cell migration in hindbrain (GO:0021535)3.07380330
57amino acid import (GO:0043090)3.06336596
58regulation of neurotransmitter levels (GO:0001505)3.04194890
59prepulse inhibition (GO:0060134)3.03667631
60regulation of synapse maturation (GO:0090128)3.01358770
61neuromuscular process controlling posture (GO:0050884)3.00707233
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00546898
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97836199
64vesicle transport along microtubule (GO:0047496)2.97366585
65neuronal ion channel clustering (GO:0045161)2.97245334
66regulation of synaptic plasticity (GO:0048167)2.96793139
67regulation of postsynaptic membrane potential (GO:0060078)2.95735631
68response to auditory stimulus (GO:0010996)2.95029228
69mating behavior (GO:0007617)2.93160131
70axon ensheathment in central nervous system (GO:0032291)2.92862289
71central nervous system myelination (GO:0022010)2.92862289
72negative regulation of dendrite morphogenesis (GO:0050774)2.91688248
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90630563
74pyrimidine nucleobase catabolic process (GO:0006208)2.89403746
75regulation of neurotransmitter secretion (GO:0046928)2.89027172
76adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.88983754
77organelle transport along microtubule (GO:0072384)2.87496136
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.86187421
79cerebellar Purkinje cell layer development (GO:0021680)2.84793390
80synaptic vesicle endocytosis (GO:0048488)2.83719363
81cerebellar Purkinje cell differentiation (GO:0021702)2.83592011
82cell communication involved in cardiac conduction (GO:0086065)2.81692861
83membrane hyperpolarization (GO:0060081)2.81438701
84gamma-aminobutyric acid signaling pathway (GO:0007214)2.81132934
85regulation of ARF protein signal transduction (GO:0032012)2.81019840
86membrane depolarization during action potential (GO:0086010)2.79572419
87axon cargo transport (GO:0008088)2.78720365
88cytoskeletal anchoring at plasma membrane (GO:0007016)2.77554251
89regulation of vesicle fusion (GO:0031338)2.76398703
90postsynaptic membrane organization (GO:0001941)2.76007416
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.75959117
92detection of calcium ion (GO:0005513)2.74721825
93dendritic spine organization (GO:0097061)2.73874825
94synapse assembly (GO:0007416)2.73425605
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71872068
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70263701
97potassium ion import (GO:0010107)2.70060114
98neuromuscular process (GO:0050905)2.69513446
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69169633
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.68802709
101regulation of neurotransmitter transport (GO:0051588)2.68007946
102alanine transport (GO:0032328)2.67546374
103membrane depolarization (GO:0051899)2.67201030
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67035337
105negative regulation of microtubule polymerization (GO:0031115)2.66208392
106positive regulation of synapse assembly (GO:0051965)2.65965490
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65592531
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.65550124
109innervation (GO:0060384)2.65470865
110establishment of mitochondrion localization (GO:0051654)2.64636949
111potassium ion homeostasis (GO:0055075)2.64124382
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.63937239
113synapse organization (GO:0050808)2.63741239
114regulation of voltage-gated calcium channel activity (GO:1901385)2.63664477
115apical protein localization (GO:0045176)2.62321545
116suckling behavior (GO:0001967)2.62020758
117mechanosensory behavior (GO:0007638)2.61873363
118positive regulation of dendritic spine development (GO:0060999)2.61863752
119cerebellar granule cell differentiation (GO:0021707)2.60639146
120cellular sodium ion homeostasis (GO:0006883)2.60433792
121positive regulation of potassium ion transmembrane transport (GO:1901381)2.59661811
122intraspecies interaction between organisms (GO:0051703)2.58927451
123social behavior (GO:0035176)2.58927451
124long-term synaptic potentiation (GO:0060291)2.58900583
125regulation of dendritic spine development (GO:0060998)2.58511697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88196959
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84438100
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82867188
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69204994
5GBX2_23144817_ChIP-Seq_PC3_Human2.66107813
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56695609
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56695609
8DROSHA_22980978_ChIP-Seq_HELA_Human2.53641294
9REST_21632747_ChIP-Seq_MESCs_Mouse2.52842845
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47806751
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46312234
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45572054
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.41916795
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30465873
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30245260
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26032148
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.24780949
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.22633580
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19963621
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13992974
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.12986299
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08751776
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.03431653
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.99065791
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95891468
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.78914452
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77263590
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75172299
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67363215
30AR_21572438_ChIP-Seq_LNCaP_Human1.66503939
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66194816
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.38292395
33KDM2B_26808549_Chip-Seq_K562_Human1.38209068
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36391641
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35795905
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35040400
37* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33682447
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.30993145
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30754001
40ZNF274_21170338_ChIP-Seq_K562_Hela1.29188576
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.28451353
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28425382
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27221019
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.26917744
45WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26024734
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25083626
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24988817
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24058551
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23514763
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21600046
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21392590
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21056720
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20983765
54RNF2_27304074_Chip-Seq_NSC_Mouse1.20529194
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19195831
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18537058
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15239097
58AR_19668381_ChIP-Seq_PC3_Human1.15146387
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14096696
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11987743
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10631169
62TAF15_26573619_Chip-Seq_HEK293_Human1.09728373
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.09495049
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07070431
65CTCF_27219007_Chip-Seq_Bcells_Human1.06144930
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04598604
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04384576
68STAT3_23295773_ChIP-Seq_U87_Human1.04274245
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03917949
70* AHR_22903824_ChIP-Seq_MCF-7_Human1.03498858
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03013325
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02150965
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.01189103
74* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99945854
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99711015
76SMAD4_21741376_ChIP-Seq_HESCs_Human0.99627695
77AR_25329375_ChIP-Seq_VCAP_Human0.99373124
78TET1_21490601_ChIP-Seq_MESCs_Mouse0.98727587
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98356082
80TP53_20018659_ChIP-ChIP_R1E_Mouse0.98305546
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98109002
82ESR2_21235772_ChIP-Seq_MCF-7_Human0.96328638
83ESR1_20079471_ChIP-ChIP_T-47D_Human0.95720433
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.94550815
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94409428
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94084485
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93731021
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92935926
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92669725
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92507799
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92463705
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91476879
93* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91358914
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90501872
95* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89094146
96ISL1_27105846_Chip-Seq_CPCs_Mouse0.88755702
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.88335283
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88205317
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.88153420
100TCF4_23295773_ChIP-Seq_U87_Human0.87128990
101CBX2_27304074_Chip-Seq_ESCs_Mouse0.86848212
102TP53_16413492_ChIP-PET_HCT116_Human0.86540957
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86299667
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86135409
105EP300_21415370_ChIP-Seq_HL-1_Mouse0.85739512
106P300_19829295_ChIP-Seq_ESCs_Human0.84684984
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84529516
108KLF4_19829295_ChIP-Seq_ESCs_Human0.83088003
109* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82921411
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82846914
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80518709
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79446207
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78302978
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.78252632
115ZNF263_19887448_ChIP-Seq_K562_Human0.78142614
116* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77355122
117RXR_22108803_ChIP-Seq_LS180_Human0.77074131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02095046
2MP0003880_abnormal_central_pattern3.96994845
3MP0004270_analgesia3.96314900
4MP0003635_abnormal_synaptic_transmissio3.81556474
5MP0002063_abnormal_learning/memory/cond3.02859519
6MP0009745_abnormal_behavioral_response2.99423387
7MP0002822_catalepsy2.84510622
8MP0005423_abnormal_somatic_nervous2.82082344
9MP0002064_seizures2.80859361
10MP0002734_abnormal_mechanical_nocicepti2.71701759
11MP0009046_muscle_twitch2.71320840
12MP0001968_abnormal_touch/_nociception2.71176592
13MP0002572_abnormal_emotion/affect_behav2.42778516
14MP0002272_abnormal_nervous_system2.39782940
15MP0001486_abnormal_startle_reflex2.38696009
16MP0003329_amyloid_beta_deposits2.33730857
17MP0009780_abnormal_chondrocyte_physiolo2.30345742
18MP0002733_abnormal_thermal_nociception2.19782390
19MP0002735_abnormal_chemical_nociception2.17933248
20MP0004858_abnormal_nervous_system2.14865949
21MP0002909_abnormal_adrenal_gland2.12314899
22MP0002736_abnormal_nociception_after1.99949565
23MP0001970_abnormal_pain_threshold1.98358744
24MP0001440_abnormal_grooming_behavior1.97447105
25MP0001501_abnormal_sleep_pattern1.95606759
26MP0000778_abnormal_nervous_system1.84941910
27MP0004885_abnormal_endolymph1.81374758
28MP0008569_lethality_at_weaning1.76957880
29MP0002067_abnormal_sensory_capabilities1.75316358
30MP0002184_abnormal_innervation1.74746008
31MP0004811_abnormal_neuron_physiology1.73914542
32MP0000955_abnormal_spinal_cord1.67826746
33MP0004924_abnormal_behavior1.66624152
34MP0005386_behavior/neurological_phenoty1.66624152
35MP0003123_paternal_imprinting1.64310142
36MP0002557_abnormal_social/conspecific_i1.59331742
37MP0005409_darkened_coat_color1.53601918
38MP0006276_abnormal_autonomic_nervous1.49544307
39MP0003633_abnormal_nervous_system1.43823690
40MP0003879_abnormal_hair_cell1.43127447
41MP0002066_abnormal_motor_capabilities/c1.40252395
42MP0002882_abnormal_neuron_morphology1.39726904
43MP0001984_abnormal_olfaction1.37958764
44MP0000751_myopathy1.28447653
45MP0003690_abnormal_glial_cell1.28112412
46MP0003283_abnormal_digestive_organ1.27461719
47MP0005645_abnormal_hypothalamus_physiol1.23675280
48MP0005646_abnormal_pituitary_gland1.22684966
49MP0000920_abnormal_myelination1.22017358
50MP0000566_synostosis1.21955110
51MP0002837_dystrophic_cardiac_calcinosis1.21110668
52MP0003631_nervous_system_phenotype1.20951871
53MP0000013_abnormal_adipose_tissue1.15652427
54MP0000604_amyloidosis1.14850685
55MP0004142_abnormal_muscle_tone1.11618174
56MP0002229_neurodegeneration1.09647587
57MP0008961_abnormal_basal_metabolism1.09372146
58MP0010234_abnormal_vibrissa_follicle1.09236901
59MP0003634_abnormal_glial_cell1.08686273
60MP0004130_abnormal_muscle_cell1.07912459
61MP0001502_abnormal_circadian_rhythm1.07521146
62MP0002152_abnormal_brain_morphology1.05419910
63MP0001188_hyperpigmentation1.02348411
64MP0005535_abnormal_body_temperature1.01596026
65MP0001529_abnormal_vocalization1.00514935
66MP0001905_abnormal_dopamine_level0.98453421
67MP0002069_abnormal_eating/drinking_beha0.97258641
68MP0003632_abnormal_nervous_system0.94127096
69MP0001177_atelectasis0.92588183
70MP0000534_abnormal_ureter_morphology0.92583242
71MP0004145_abnormal_muscle_electrophysio0.90542613
72MP0008872_abnormal_physiological_respon0.90061505
73MP0000579_abnormal_nail_morphology0.89906099
74MP0003121_genomic_imprinting0.89877963
75MP0002638_abnormal_pupillary_reflex0.88802417
76MP0008874_decreased_physiological_sensi0.87614519
77MP0004742_abnormal_vestibular_system0.87329372
78MP0004085_abnormal_heartbeat0.87019828
79MP0004043_abnormal_pH_regulation0.86490917
80MP0003075_altered_response_to0.83524773
81MP0003137_abnormal_impulse_conducting0.83293026
82MP0005167_abnormal_blood-brain_barrier0.81855542
83MP0003787_abnormal_imprinting0.78821798
84MP0003861_abnormal_nervous_system0.78255966
85MP0000462_abnormal_digestive_system0.77640413
86MP0002090_abnormal_vision0.77058243
87MP0005551_abnormal_eye_electrophysiolog0.76314097
88MP0005187_abnormal_penis_morphology0.74335876
89MP0002752_abnormal_somatic_nervous0.71691046
90MP0000747_muscle_weakness0.71580342
91MP0004215_abnormal_myocardial_fiber0.71397645
92MP0003122_maternal_imprinting0.70406380
93MP0001299_abnormal_eye_distance/0.70162362
94MP0002876_abnormal_thyroid_physiology0.68998099
95MP0000026_abnormal_inner_ear0.66339401
96MP0001963_abnormal_hearing_physiology0.65769074
97MP0000569_abnormal_digit_pigmentation0.65171366
98MP0003942_abnormal_urinary_system0.65052901
99MP0001348_abnormal_lacrimal_gland0.64588672
100MP0010769_abnormal_survival0.64481432
101MP0001664_abnormal_digestion0.64109926
102MP0010770_preweaning_lethality0.63922301
103MP0002082_postnatal_lethality0.63922301
104MP0005623_abnormal_meninges_morphology0.62922954
105MP0000003_abnormal_adipose_tissue0.62336915
106MP0001485_abnormal_pinna_reflex0.61941255
107MP0010386_abnormal_urinary_bladder0.61730784
108MP0005394_taste/olfaction_phenotype0.60677007
109MP0005499_abnormal_olfactory_system0.60677007
110MP0001943_abnormal_respiration0.59574109
111MP0002249_abnormal_larynx_morphology0.59447394
112MP0010768_mortality/aging0.59332826
113MP0003938_abnormal_ear_development0.59092216
114MP0000631_abnormal_neuroendocrine_gland0.58119118
115MP0003868_abnormal_feces_composition0.57246695
116MP0004233_abnormal_muscle_weight0.57060722
117MP0002234_abnormal_pharynx_morphology0.56458131
118MP0004484_altered_response_of0.54476793
119MP0002081_perinatal_lethality0.54275650
120MP0005448_abnormal_energy_balance0.53214462
121MP0003172_abnormal_lysosome_physiology0.52104814

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.50690594
2Focal motor seizures (HP:0011153)5.43214689
3Visual hallucinations (HP:0002367)4.72911556
4Focal seizures (HP:0007359)4.67765130
5Supranuclear gaze palsy (HP:0000605)4.20754684
6Action tremor (HP:0002345)4.15307023
7Ankle clonus (HP:0011448)3.97033968
8Neurofibrillary tangles (HP:0002185)3.58386238
9Epileptic encephalopathy (HP:0200134)3.50273549
10Progressive cerebellar ataxia (HP:0002073)3.48534756
11Cerebral inclusion bodies (HP:0100314)3.37831898
12Atonic seizures (HP:0010819)3.34943654
13Mutism (HP:0002300)3.20525109
14Generalized tonic-clonic seizures (HP:0002069)3.18152962
15Abnormality of the lower motor neuron (HP:0002366)3.17418257
16Absence seizures (HP:0002121)3.16262054
17Insidious onset (HP:0003587)3.13872296
18Termporal pattern (HP:0011008)3.13872296
19Abnormality of the corticospinal tract (HP:0002492)3.13327927
20Urinary bladder sphincter dysfunction (HP:0002839)3.04707467
21Depression (HP:0000716)3.02306663
22Poor eye contact (HP:0000817)3.00721512
23Torticollis (HP:0000473)2.99033190
24Intention tremor (HP:0002080)2.96240411
25Impaired vibration sensation in the lower limbs (HP:0002166)2.95788488
26Spastic gait (HP:0002064)2.95152207
27Dysmetria (HP:0001310)2.91198183
28Impaired social interactions (HP:0000735)2.90975238
29Abnormal social behavior (HP:0012433)2.90975238
30Dialeptic seizures (HP:0011146)2.89859580
31Urinary urgency (HP:0000012)2.89774198
32Abnormal eating behavior (HP:0100738)2.86586698
33Febrile seizures (HP:0002373)2.85771208
34Postural instability (HP:0002172)2.84507050
35Dysdiadochokinesis (HP:0002075)2.83253020
36Anxiety (HP:0000739)2.80114074
37Ventricular fibrillation (HP:0001663)2.76576861
38Papilledema (HP:0001085)2.76059019
39Pheochromocytoma (HP:0002666)2.75776864
40Broad-based gait (HP:0002136)2.67073582
41Focal dystonia (HP:0004373)2.64097467
42Truncal ataxia (HP:0002078)2.56912215
43Megalencephaly (HP:0001355)2.53798348
44Limb dystonia (HP:0002451)2.51429533
45Scanning speech (HP:0002168)2.51410664
46Craniofacial dystonia (HP:0012179)2.50561018
47Lower limb muscle weakness (HP:0007340)2.50325071
48Gaze-evoked nystagmus (HP:0000640)2.48643889
49Insomnia (HP:0100785)2.48459591
50Sleep apnea (HP:0010535)2.39925652
51Amblyopia (HP:0000646)2.35463777
52Excessive salivation (HP:0003781)2.34507760
53Drooling (HP:0002307)2.34507760
54Genetic anticipation (HP:0003743)2.33936343
55Bundle branch block (HP:0011710)2.32718860
56Bronchomalacia (HP:0002780)2.31928385
57Hemiplegia (HP:0002301)2.31867548
58Hemiparesis (HP:0001269)2.31450240
59Clonus (HP:0002169)2.31122055
60Amyotrophic lateral sclerosis (HP:0007354)2.30946093
61Hyperventilation (HP:0002883)2.26478611
62EEG with generalized epileptiform discharges (HP:0011198)2.25680472
63Epileptiform EEG discharges (HP:0011182)2.23542802
64Hypsarrhythmia (HP:0002521)2.22972561
65Bradykinesia (HP:0002067)2.21535544
66Neuroendocrine neoplasm (HP:0100634)2.21521623
67Progressive inability to walk (HP:0002505)2.20544421
68Agitation (HP:0000713)2.13083203
69Morphological abnormality of the pyramidal tract (HP:0002062)2.11439810
70Polyphagia (HP:0002591)2.11384704
71Akinesia (HP:0002304)2.10889587
72Aplasia involving bones of the upper limbs (HP:0009823)2.10453863
73Aplasia of the phalanges of the hand (HP:0009802)2.10453863
74Aplasia involving bones of the extremities (HP:0009825)2.10453863
75Macroorchidism (HP:0000053)2.04859965
76Neuronal loss in central nervous system (HP:0002529)2.04079168
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.02998542
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02998542
79Dysmetric saccades (HP:0000641)2.01792563
80Absent speech (HP:0001344)2.01318668
81Diplopia (HP:0000651)2.00377800
82Abnormality of binocular vision (HP:0011514)2.00377800
83Status epilepticus (HP:0002133)2.00068230
84Rapidly progressive (HP:0003678)1.99718049
85Impaired vibratory sensation (HP:0002495)1.96427407
86Impaired smooth pursuit (HP:0007772)1.96322741
87Stereotypic behavior (HP:0000733)1.93100063
88Generalized myoclonic seizures (HP:0002123)1.91080451
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91002617
90Hammertoe (HP:0001765)1.88289929
91Hyperacusis (HP:0010780)1.86600333
92Fetal akinesia sequence (HP:0001989)1.85821549
93Rigidity (HP:0002063)1.84427016
94Neoplasm of the peripheral nervous system (HP:0100007)1.83604636
95Abnormal EKG (HP:0003115)1.83207934
96Prolonged QT interval (HP:0001657)1.82874953
97Postural tremor (HP:0002174)1.82320361
98Apathy (HP:0000741)1.82128970
99Onion bulb formation (HP:0003383)1.81121917
100Resting tremor (HP:0002322)1.79039107
101Obstructive sleep apnea (HP:0002870)1.79022734
102Gait ataxia (HP:0002066)1.78383364
103Spastic tetraparesis (HP:0001285)1.76361255
104Anosmia (HP:0000458)1.76124579
105Abnormality of ocular smooth pursuit (HP:0000617)1.75880145
106Arterial tortuosity (HP:0005116)1.74496078
107Pointed chin (HP:0000307)1.74151088
108Syncope (HP:0001279)1.73632162
109Tetraplegia (HP:0002445)1.72287792
110Neoplasm of the heart (HP:0100544)1.68581253
111Heterochromia iridis (HP:0001100)1.67742373
112Increased circulating renin level (HP:0000848)1.65641023
113Hypercortisolism (HP:0001578)1.63238287
114Renovascular hypertension (HP:0100817)1.61456051
115Vascular tortuosity (HP:0004948)1.61215825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.09246515
2MAP3K93.98418342
3NTRK33.50035939
4EPHA43.31154816
5MINK12.63326473
6MAP3K42.50076919
7DAPK22.35488969
8PAK62.35161621
9PRKD32.34152437
10NTRK12.31554663
11KSR22.30319269
12NTRK22.04999542
13CAMKK11.82146044
14PHKG11.80587018
15PHKG21.80587018
16MAP2K71.71821087
17MAP2K41.71736237
18MAP3K21.56926369
19LMTK21.54160089
20CDK51.51627384
21TYRO31.43790801
22KSR11.39352509
23LATS21.37817026
24STK381.29229471
25GRK51.23338614
26UHMK11.19241007
27TAOK11.16644563
28MAPK131.15074363
29RET1.14908063
30MAP3K121.10043695
31PRPF4B1.09684701
32RIPK11.08026711
33PAK31.05727503
34PRKCG1.01718643
35SIK21.01677247
36NEK61.00284337
37STK110.98659470
38PRKCH0.97231801
39SGK4940.96301473
40SGK2230.96301473
41ARAF0.94756482
42DAPK10.93279036
43PNCK0.92898784
44CSNK1G20.91729103
45TNIK0.91717282
46PINK10.90494630
47PIK3CA0.89743352
48MARK20.87626352
49ALK0.84900518
50OXSR10.84396354
51CAMK2A0.84098697
52CDK150.82614563
53CDK140.82442979
54STK390.82153683
55CAMKK20.81036410
56TRIB30.80891103
57CDK180.80839904
58CDK190.79625830
59CASK0.79252061
60ICK0.79208355
61RIPK40.77335795
62CAMK1G0.77039632
63PLK20.76513993
64PDPK10.75963935
65FGFR20.71730890
66SCYL20.71544057
67SIK10.71366263
68CAMK2B0.70686745
69CDK11A0.70044082
70CAMK10.69875631
71FES0.69041165
72WNK10.68404075
73MAP3K10.68073880
74PRKCZ0.67929757
75PDK10.66718305
76EPHB20.66520776
77FER0.65975557
78EEF2K0.65125312
79MAPK120.63735975
80PKN10.63676940
81MAPK100.62310355
82ERBB20.60429052
83PTK20.58908822
84LIMK10.57170312
85ROCK20.57016192
86DYRK1A0.56884893
87CDC42BPA0.56691484
88MAP3K130.56145809
89SGK10.55618758
90SGK30.55062765
91EPHA20.54607369
92PDGFRA0.52745084
93CAMK2G0.52732903
94CAMK2D0.52698758
95WNK40.52637590
96FYN0.52148948
97MAP2K10.51674800
98DDR20.49323975
99RPS6KB10.49281480
100PTK2B0.48699455
101RPS6KA30.48521876
102AKT30.48193558
103DYRK20.47175173
104RPS6KA20.46833630
105CAMK40.46648100
106PDK30.45421670
107PDK40.45421670
108PRKCE0.45305212
109TNK20.44290157
110CSNK1G30.44240454
111SGK20.43915350
112ROCK10.43890662
113PDGFRB0.43662199
114MAPK150.43647227
115MAP3K70.43224266
116RAF10.42030747
117NEK10.41318843
118TESK10.41163872
119MET0.37989073
120CSNK1D0.37077869
121EPHA30.36429674

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.86569365
2Nicotine addiction_Homo sapiens_hsa050332.77850084
3Olfactory transduction_Homo sapiens_hsa047402.41081720
4GABAergic synapse_Homo sapiens_hsa047272.40221317
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30566954
6Circadian entrainment_Homo sapiens_hsa047132.29772864
7Glutamatergic synapse_Homo sapiens_hsa047242.20465436
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15202158
9Long-term potentiation_Homo sapiens_hsa047202.14871155
10Nitrogen metabolism_Homo sapiens_hsa009102.05923309
11Morphine addiction_Homo sapiens_hsa050322.05156357
12Amphetamine addiction_Homo sapiens_hsa050311.96420173
13Salivary secretion_Homo sapiens_hsa049701.92877388
14Dopaminergic synapse_Homo sapiens_hsa047281.90098855
15Insulin secretion_Homo sapiens_hsa049111.84322316
16Gastric acid secretion_Homo sapiens_hsa049711.77162278
17Cholinergic synapse_Homo sapiens_hsa047251.74165227
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68478223
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62492345
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59769046
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57060957
22Renin secretion_Homo sapiens_hsa049241.51414473
23Cocaine addiction_Homo sapiens_hsa050301.49950759
24Taste transduction_Homo sapiens_hsa047421.45035625
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38243181
26Long-term depression_Homo sapiens_hsa047301.37736933
27Oxytocin signaling pathway_Homo sapiens_hsa049211.35387668
28GnRH signaling pathway_Homo sapiens_hsa049121.28943308
29Gap junction_Homo sapiens_hsa045401.28900113
30Type II diabetes mellitus_Homo sapiens_hsa049301.28085532
31Serotonergic synapse_Homo sapiens_hsa047261.25890815
32Calcium signaling pathway_Homo sapiens_hsa040201.21767039
33Axon guidance_Homo sapiens_hsa043601.20048519
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14137681
35Estrogen signaling pathway_Homo sapiens_hsa049151.13308550
36cAMP signaling pathway_Homo sapiens_hsa040241.10905299
37Bile secretion_Homo sapiens_hsa049761.07745644
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04364594
39Butanoate metabolism_Homo sapiens_hsa006501.01450545
40Glioma_Homo sapiens_hsa052140.99687357
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98312321
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98181611
43Vitamin B6 metabolism_Homo sapiens_hsa007500.96110368
44Dorso-ventral axis formation_Homo sapiens_hsa043200.93687996
45ErbB signaling pathway_Homo sapiens_hsa040120.93093467
46Melanogenesis_Homo sapiens_hsa049160.92491268
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90749309
48Collecting duct acid secretion_Homo sapiens_hsa049660.89748680
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88991433
50Pancreatic secretion_Homo sapiens_hsa049720.88008022
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86491023
52Cardiac muscle contraction_Homo sapiens_hsa042600.85703769
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.84470806
54Thyroid hormone synthesis_Homo sapiens_hsa049180.84238329
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83523274
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.81961696
57Arginine biosynthesis_Homo sapiens_hsa002200.81400727
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79245674
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78025767
60Fatty acid biosynthesis_Homo sapiens_hsa000610.70058652
61Dilated cardiomyopathy_Homo sapiens_hsa054140.69059712
62Vibrio cholerae infection_Homo sapiens_hsa051100.68596599
63Histidine metabolism_Homo sapiens_hsa003400.68490495
64Choline metabolism in cancer_Homo sapiens_hsa052310.64698992
65Hippo signaling pathway_Homo sapiens_hsa043900.63315785
66Glucagon signaling pathway_Homo sapiens_hsa049220.62679327
67Circadian rhythm_Homo sapiens_hsa047100.60171489
68Oocyte meiosis_Homo sapiens_hsa041140.59701344
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59187132
70Insulin signaling pathway_Homo sapiens_hsa049100.58500649
71Endometrial cancer_Homo sapiens_hsa052130.57921718
72Prion diseases_Homo sapiens_hsa050200.57203051
73VEGF signaling pathway_Homo sapiens_hsa043700.56992070
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55356361
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54801210
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54552493
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.53380537
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53044506
79mTOR signaling pathway_Homo sapiens_hsa041500.52525941
80Endocytosis_Homo sapiens_hsa041440.51812735
81Wnt signaling pathway_Homo sapiens_hsa043100.51808312
82Protein digestion and absorption_Homo sapiens_hsa049740.51093641
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50635395
84Renal cell carcinoma_Homo sapiens_hsa052110.49954658
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49679778
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.49074970
87MAPK signaling pathway_Homo sapiens_hsa040100.48925212
88Mineral absorption_Homo sapiens_hsa049780.48859023
89Ras signaling pathway_Homo sapiens_hsa040140.48241053
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.46970894
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46899444
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46803702
93Glycerolipid metabolism_Homo sapiens_hsa005610.46126316
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45571704
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44627004
96Rap1 signaling pathway_Homo sapiens_hsa040150.43728509
97Adherens junction_Homo sapiens_hsa045200.43462473
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43284970
99Phototransduction_Homo sapiens_hsa047440.42957361
100ECM-receptor interaction_Homo sapiens_hsa045120.42816804
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42660348
102beta-Alanine metabolism_Homo sapiens_hsa004100.42089206
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41911629
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40924662
105Fatty acid metabolism_Homo sapiens_hsa012120.40232659
106Focal adhesion_Homo sapiens_hsa045100.39839702
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39757158
108Tight junction_Homo sapiens_hsa045300.39034721
109Ovarian steroidogenesis_Homo sapiens_hsa049130.38830814
110Alcoholism_Homo sapiens_hsa050340.37918377
111AMPK signaling pathway_Homo sapiens_hsa041520.37789438
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37723513
113Prolactin signaling pathway_Homo sapiens_hsa049170.37553339
114Inositol phosphate metabolism_Homo sapiens_hsa005620.37312264
115PPAR signaling pathway_Homo sapiens_hsa033200.36371768
116Non-small cell lung cancer_Homo sapiens_hsa052230.35311136

Most similar genes based on co-expression Upload to Enrichr

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