ATP9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of developmental pigmentation (GO:0048087)5.20585239
2regulation of pigment cell differentiation (GO:0050932)4.99782075
3interkinetic nuclear migration (GO:0022027)4.57210887
4protein K48-linked deubiquitination (GO:0071108)4.42286623
5monoubiquitinated protein deubiquitination (GO:0035520)4.37393970
6regulation of establishment of cell polarity (GO:2000114)4.29806352
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.19442770
8negative regulation of translation, ncRNA-mediated (GO:0040033)4.19442770
9regulation of translation, ncRNA-mediated (GO:0045974)4.19442770
10snRNA transcription (GO:0009301)4.12038689
11cilium or flagellum-dependent cell motility (GO:0001539)4.07703965
12tryptophan catabolic process (GO:0006569)4.07056946
13indole-containing compound catabolic process (GO:0042436)4.07056946
14indolalkylamine catabolic process (GO:0046218)4.07056946
15regulation of hippo signaling (GO:0035330)3.84630872
16regulation of establishment or maintenance of cell polarity (GO:0032878)3.75442836
17indolalkylamine metabolic process (GO:0006586)3.75160991
18protein K11-linked deubiquitination (GO:0035871)3.73406073
19kynurenine metabolic process (GO:0070189)3.72025042
20positive regulation of gamma-delta T cell activation (GO:0046645)3.69740006
21positive regulation of histone deacetylation (GO:0031065)3.66792286
22protein K63-linked deubiquitination (GO:0070536)3.60304797
23peptidyl-tyrosine autophosphorylation (GO:0038083)3.59414876
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56831679
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56831679
26cellular response to ethanol (GO:0071361)3.54768737
27protein targeting to vacuole (GO:0006623)3.53990652
28protein targeting to lysosome (GO:0006622)3.53990652
29establishment of protein localization to vacuole (GO:0072666)3.53990652
30neural tube formation (GO:0001841)3.49160953
31negative regulation of protein localization to cell surface (GO:2000009)3.49051771
32tryptophan metabolic process (GO:0006568)3.46447670
33growth hormone receptor signaling pathway (GO:0060396)3.45227108
34negative regulation of sodium ion transport (GO:0010766)3.43348390
35endosome to pigment granule transport (GO:0043485)3.40660681
36endosome to melanosome transport (GO:0035646)3.40660681
37regulation of gene silencing by RNA (GO:0060966)3.34954095
38regulation of posttranscriptional gene silencing (GO:0060147)3.34954095
39regulation of gene silencing by miRNA (GO:0060964)3.34954095
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30822781
41macroautophagy (GO:0016236)3.29130234
42signal peptide processing (GO:0006465)3.26219876
43fusion of sperm to egg plasma membrane (GO:0007342)3.23921938
44oxidative demethylation (GO:0070989)3.20119959
45apoptotic cell clearance (GO:0043277)3.17558268
46negative regulation of cell killing (GO:0031342)3.16944946
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16944946
48sulfation (GO:0051923)3.16507002
49regulation of sarcomere organization (GO:0060297)3.16299147
50gamma-aminobutyric acid transport (GO:0015812)3.12663872
51antigen processing and presentation of endogenous antigen (GO:0019883)3.10758955
52regulation of cholesterol storage (GO:0010885)3.10569061
53regulation of gamma-delta T cell differentiation (GO:0045586)3.09114264
54thyroid hormone metabolic process (GO:0042403)3.08324761
55detection of light stimulus involved in sensory perception (GO:0050962)3.07511564
56detection of light stimulus involved in visual perception (GO:0050908)3.07511564
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06429628
58cardiovascular system development (GO:0072358)3.06362312
59flavonoid metabolic process (GO:0009812)3.04200947
60behavioral response to nicotine (GO:0035095)3.02344572
61photoreceptor cell maintenance (GO:0045494)3.00896100
62histone H3-K4 trimethylation (GO:0080182)2.99786251
63negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98718499
64histone H3-K9 methylation (GO:0051567)2.96367296
65cellular response to growth hormone stimulus (GO:0071378)2.95299749
66positive thymic T cell selection (GO:0045059)2.94456161
67regulation of interleukin-12 biosynthetic process (GO:0045075)2.93769932
68negative regulation of systemic arterial blood pressure (GO:0003085)2.92014350
69nucleus localization (GO:0051647)2.89579159
70protein localization to endosome (GO:0036010)2.88887518
71regulation of cholesterol homeostasis (GO:2000188)2.87073531
72regulation of gamma-delta T cell activation (GO:0046643)2.86595521
73regulation of fatty acid beta-oxidation (GO:0031998)2.85962400
74reflex (GO:0060004)2.85487188
75glucocorticoid receptor signaling pathway (GO:0042921)2.85024191
76pericardium development (GO:0060039)2.82124577
77plasma membrane fusion (GO:0045026)2.81518512
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78631456
79cellular response to sterol (GO:0036315)2.75828315
80L-fucose catabolic process (GO:0042355)2.73314911
81fucose catabolic process (GO:0019317)2.73314911
82L-fucose metabolic process (GO:0042354)2.73314911
83negative regulation of mast cell activation (GO:0033004)2.72926757
84appendage development (GO:0048736)2.72702078
85limb development (GO:0060173)2.72702078
86negative regulation of erythrocyte differentiation (GO:0045647)2.72482511
87indole-containing compound metabolic process (GO:0042430)2.71622232
88phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.71211970
89peptidyl-lysine dimethylation (GO:0018027)2.70810944
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69034796
91regulation of developmental pigmentation (GO:0048070)2.67859210
92microtubule anchoring (GO:0034453)2.65447556
93positive regulation of fatty acid beta-oxidation (GO:0032000)2.65351398
94mannose metabolic process (GO:0006013)2.63946059
95cilium organization (GO:0044782)2.62199621
96negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.60958873
97establishment of nucleus localization (GO:0040023)2.60526641
98cell adhesion mediated by integrin (GO:0033627)2.60208065
99cilium assembly (GO:0042384)2.59934776
100alpha-linolenic acid metabolic process (GO:0036109)2.59528110
101cilium movement (GO:0003341)2.58507941
102low-density lipoprotein particle clearance (GO:0034383)2.57088951
103negative regulation of sterol transport (GO:0032372)2.55079684
104negative regulation of cholesterol transport (GO:0032375)2.55079684
105peptidyl-lysine methylation (GO:0018022)2.55019453
106membrane depolarization during action potential (GO:0086010)2.53736550
107protein localization to Golgi apparatus (GO:0034067)2.52994865
108regulation of ARF protein signal transduction (GO:0032012)2.51900793
109cortical actin cytoskeleton organization (GO:0030866)2.51638788
110cAMP catabolic process (GO:0006198)2.50896283
111lipoprotein transport (GO:0042953)2.50505334
112regulation of ARF GTPase activity (GO:0032312)2.49796975
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.49269455
114cerebellar Purkinje cell differentiation (GO:0021702)2.48931905
115NAD biosynthetic process (GO:0009435)2.48634642
116regulation of protein polyubiquitination (GO:1902914)2.48629551
117histone H3-K9 modification (GO:0061647)2.45400613
118heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.45246231
119cytoplasmic mRNA processing body assembly (GO:0033962)2.44854171
120cilium morphogenesis (GO:0060271)2.44388905
121central nervous system neuron axonogenesis (GO:0021955)2.41830240
122rRNA catabolic process (GO:0016075)2.41269387
123phospholipid homeostasis (GO:0055091)2.40978164
124corticosteroid receptor signaling pathway (GO:0031958)2.37755580
125histone lysine methylation (GO:0034968)2.37355276
126cyclic nucleotide catabolic process (GO:0009214)2.37321326
127peptidyl-lysine trimethylation (GO:0018023)2.37302695
128positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.37285300
129spinal cord motor neuron differentiation (GO:0021522)2.37140226
130positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.37027343
131negative regulation of protein autophosphorylation (GO:0031953)2.37014637
132negative thymic T cell selection (GO:0045060)2.36633451
133epithelial cilium movement (GO:0003351)2.35393731
134serotonin metabolic process (GO:0042428)2.34138022
135signal complex assembly (GO:0007172)2.33857646
136proline transport (GO:0015824)2.33752176
137behavioral response to ethanol (GO:0048149)2.32675905
138triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.32149438
139regulation of interferon-beta biosynthetic process (GO:0045357)2.31413917
140pigment cell differentiation (GO:0050931)2.30818146
141protein-lipid complex assembly (GO:0065005)2.30616755
142endocardial cushion development (GO:0003197)2.30119753
143thymic T cell selection (GO:0045061)2.29856646
144axon extension involved in axon guidance (GO:0048846)2.29588569
145neuron projection extension involved in neuron projection guidance (GO:1902284)2.29588569
146sperm motility (GO:0030317)2.28468602
147NLS-bearing protein import into nucleus (GO:0006607)2.28409202
148positive regulation of glycogen biosynthetic process (GO:0045725)2.27970942
149positive T cell selection (GO:0043368)2.27737031
150JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.27516625
151negative T cell selection (GO:0043383)2.27007800
152stress fiber assembly (GO:0043149)2.26869036
153retrograde transport, vesicle recycling within Golgi (GO:0000301)2.23654695
154negative regulation of lipid transport (GO:0032369)2.20896313
155dicarboxylic acid biosynthetic process (GO:0043650)2.20592338
156I-kappaB phosphorylation (GO:0007252)2.20421358
157cytoskeletal anchoring at plasma membrane (GO:0007016)2.20239664
158negative regulation of fibrinolysis (GO:0051918)2.18931133
159plasma lipoprotein particle clearance (GO:0034381)2.18553757
160positive regulation of lipid catabolic process (GO:0050996)2.18228618
161plasma lipoprotein particle assembly (GO:0034377)2.16931236
162urea cycle (GO:0000050)2.16483807
163urea metabolic process (GO:0019627)2.16483807
164regulation of lipid catabolic process (GO:0050994)2.14173739
165positive regulation of glycogen metabolic process (GO:0070875)2.14057280
166regulation of triglyceride catabolic process (GO:0010896)2.13497120
167* phospholipid translocation (GO:0045332)2.12985838
168* lipid translocation (GO:0034204)2.12985838
169synaptic vesicle docking involved in exocytosis (GO:0016081)2.12535533
170regulation of B cell receptor signaling pathway (GO:0050855)2.12098320
171positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.11457057
172sexual reproduction (GO:0019953)2.10102688
173activation of protein kinase A activity (GO:0034199)2.09989985
174cortical cytoskeleton organization (GO:0030865)2.07734705
175stress granule assembly (GO:0034063)2.07176050
176activation of JUN kinase activity (GO:0007257)2.07050255
177response to laminar fluid shear stress (GO:0034616)2.05785877
178peptidyl-glutamic acid carboxylation (GO:0017187)2.05273066
179protein carboxylation (GO:0018214)2.05273066
180sodium ion export (GO:0071436)2.05225093
181protein targeting to Golgi (GO:0000042)2.04760393
182* establishment of protein localization to Golgi (GO:0072600)2.04760393
183nerve growth factor signaling pathway (GO:0038180)2.04607466
184heparan sulfate proteoglycan metabolic process (GO:0030201)2.04316585
185positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.03267315
186positive regulation by symbiont of host defense response (GO:0052509)2.03158652
187modulation by symbiont of host defense response (GO:0052031)2.03158652
188modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.03158652
189modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.03158652
190positive regulation by organism of defense response of other organism involved in symbiotic interact2.03158652
191modulation by symbiont of host immune response (GO:0052553)2.03158652
192natural killer cell differentiation (GO:0001779)2.02513201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.48699811
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76290286
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.75095524
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71118654
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65538232
6EZH2_22144423_ChIP-Seq_EOC_Human2.59491764
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43257752
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36230177
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35540142
10VDR_22108803_ChIP-Seq_LS180_Human2.34790679
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.34304875
12ZNF274_21170338_ChIP-Seq_K562_Hela2.31010146
13TAF15_26573619_Chip-Seq_HEK293_Human2.28484297
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.27720624
15IGF1R_20145208_ChIP-Seq_DFB_Human2.26054006
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21306520
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19775956
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.17241425
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13672096
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11062856
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05546964
22STAT3_23295773_ChIP-Seq_U87_Human2.02907575
23KDM2B_26808549_Chip-Seq_DND41_Human1.99427099
24TCF7_22412390_ChIP-Seq_EML_Mouse1.95817999
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.91867390
26P300_19829295_ChIP-Seq_ESCs_Human1.90773807
27SMAD4_21799915_ChIP-Seq_A2780_Human1.90660012
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.89525320
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.88405444
30ER_23166858_ChIP-Seq_MCF-7_Human1.86539041
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84698664
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83148368
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82817730
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.80744855
35AR_21572438_ChIP-Seq_LNCaP_Human1.80410547
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.78993491
37FUS_26573619_Chip-Seq_HEK293_Human1.76841083
38* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76012780
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75400558
40EWS_26573619_Chip-Seq_HEK293_Human1.74269103
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.74242385
42* TCF4_23295773_ChIP-Seq_U87_Human1.73867677
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71756842
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70714380
45DROSHA_22980978_ChIP-Seq_HELA_Human1.68765861
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68344257
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67800394
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67800394
49RUNX_20019798_ChIP-Seq_JUKART_Human1.65850300
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.65805631
51MYC_22102868_ChIP-Seq_BL_Human1.63806109
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.63348799
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61248258
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60486216
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59695534
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58725833
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57622988
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57501326
59GATA1_22025678_ChIP-Seq_K562_Human1.56199913
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56002057
61CBP_20019798_ChIP-Seq_JUKART_Human1.56002057
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54571376
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.54569249
64BCAT_22108803_ChIP-Seq_LS180_Human1.54193623
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53567078
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52542625
67LXR_22292898_ChIP-Seq_THP-1_Human1.51332948
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50994964
69AR_25329375_ChIP-Seq_VCAP_Human1.50396960
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.49738104
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.49690731
72KDM2B_26808549_Chip-Seq_K562_Human1.48290444
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47613404
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.47032906
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46076105
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45665978
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44194911
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43976952
79SPI1_23127762_ChIP-Seq_K562_Human1.42840938
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39449006
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.38442563
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38282866
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37558224
84MAF_26560356_Chip-Seq_TH1_Human1.36518449
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36167622
86CLOCK_20551151_ChIP-Seq_293T_Human1.36128433
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35579372
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.34457196
89* VDR_21846776_ChIP-Seq_THP-1_Human1.34158876
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31784900
91RUNX2_22187159_ChIP-Seq_PCA_Human1.30489543
92TCF4_22108803_ChIP-Seq_LS180_Human1.29415797
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28953869
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28927823
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28142538
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28132343
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27648505
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.26966136
99* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26446411
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26162933
101* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25112399
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24425069
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23838235
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.23743140
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23344602
106ZNF263_19887448_ChIP-Seq_K562_Human1.22800491
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.22248990
108VDR_24763502_ChIP-Seq_THP-1_Human1.21855436
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.21745539
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21710535
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21498890
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20660752
113* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20629950
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20059850
115RXR_22108803_ChIP-Seq_LS180_Human1.19160434
116RARB_27405468_Chip-Seq_BRAIN_Mouse1.18982586
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.17869735
118KDM2B_26808549_Chip-Seq_REH_Human1.16209657
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.15064136
120FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13618168
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13356074
122P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13173361
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13087609
124REST_21632747_ChIP-Seq_MESCs_Mouse1.12671705
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12463704
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12322577
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.11867257
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11853651
129RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11767670
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11765912
131UTX_26944678_Chip-Seq_JUKART_Human1.10392870
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10373614
133IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10099361
134SCL_19346495_ChIP-Seq_HPC-7_Human1.09879847
135BP1_19119308_ChIP-ChIP_Hs578T_Human1.09867212
136IRF1_19129219_ChIP-ChIP_H3396_Human1.08732064
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08655256
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08260324
139E2F1_18555785_Chip-Seq_ESCs_Mouse1.08020844
140* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07605679
141MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06670981
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06431533
143* AR_19668381_ChIP-Seq_PC3_Human1.06345113
144EGR1_19374776_ChIP-ChIP_THP-1_Human1.06190497
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06143047
146P53_22387025_ChIP-Seq_ESCs_Mouse1.03966939
147FOXO3_23340844_ChIP-Seq_DLD1_Human1.03540733
148* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02762263
149AHR_22903824_ChIP-Seq_MCF-7_Human1.02532545
150CBX2_27304074_Chip-Seq_ESCs_Mouse1.01936114
151SMAD3_21741376_ChIP-Seq_HESCs_Human1.01193933
152SMAD3_21741376_ChIP-Seq_ESCs_Human1.01124168
153NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01022479
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01022479
155CDX2_22108803_ChIP-Seq_LS180_Human1.00306764
156ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00250588
157WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99975555
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99895448
159GATA2_19941826_ChIP-Seq_K562_Human0.99300565
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.99062903
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98689100
162FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98391077
163ESR2_21235772_ChIP-Seq_MCF-7_Human0.97719206
164RNF2_27304074_Chip-Seq_NSC_Mouse0.97694702
165ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97510935
166* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97470137
167CRX_20693478_ChIP-Seq_RETINA_Mouse0.97448634
168SOX2_19829295_ChIP-Seq_ESCs_Human0.96126386
169NANOG_19829295_ChIP-Seq_ESCs_Human0.96126386
170VDR_24787735_ChIP-Seq_THP-1_Human0.96013219
171TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95929931
172RUNX1_27514584_Chip-Seq_MCF-7_Human0.95256525
173MYB_26560356_Chip-Seq_TH1_Human0.94745382
174GATA1_19941826_ChIP-Seq_K562_Human0.94720456
175NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92417863
176CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92176120
177TBX20_22080862_ChIP-Seq_HEART_Mouse0.91813090
178TBX20_22328084_ChIP-Seq_HEART_Mouse0.91813090
179CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91525296
180ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90934983
181TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90917687
182GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89457412
183TP53_16413492_ChIP-PET_HCT116_Human0.89320958
184* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89317227
185PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88938698
186RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88499951
187KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88361116
188DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87742615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.92256173
2MP0000569_abnormal_digit_pigmentation3.80039119
3MP0003646_muscle_fatigue3.47006399
4MP0003195_calcinosis3.34498009
5MP0003705_abnormal_hypodermis_morpholog3.01395547
6MP0003300_gastrointestinal_ulcer3.01042152
7MP0003303_peritoneal_inflammation2.84908088
8MP0004859_abnormal_synaptic_plasticity2.78030087
9MP0004043_abnormal_pH_regulation2.73847634
10MP0009046_muscle_twitch2.48319367
11MP0000383_abnormal_hair_follicle2.40120912
12MP0005410_abnormal_fertilization2.30728821
13MP0000427_abnormal_hair_cycle2.29939550
14MP0003045_fibrosis2.23517947
15MP0008438_abnormal_cutaneous_collagen2.19991464
16MP0009840_abnormal_foam_cell2.19353730
17MP0002139_abnormal_hepatobiliary_system2.16538267
18MP0001501_abnormal_sleep_pattern2.15470192
19MP0005076_abnormal_cell_differentiation2.11491819
20MP0005551_abnormal_eye_electrophysiolog2.11088330
21MP0000604_amyloidosis2.11035851
22MP0003252_abnormal_bile_duct2.02416967
23MP0004510_myositis2.00707615
24MP0009278_abnormal_bone_marrow1.98989229
25MP0001968_abnormal_touch/_nociception1.98509305
26MP0001958_emphysema1.97740684
27MP0008961_abnormal_basal_metabolism1.97054542
28MP0008877_abnormal_DNA_methylation1.88377850
29MP0005646_abnormal_pituitary_gland1.84148380
30MP0005360_urolithiasis1.83093928
31MP0000685_abnormal_immune_system1.80448939
32MP0003436_decreased_susceptibility_to1.79655954
33MP0004130_abnormal_muscle_cell1.79106122
34MP0001835_abnormal_antigen_presentation1.78634970
35MP0010329_abnormal_lipoprotein_level1.75467142
36MP0005167_abnormal_blood-brain_barrier1.74436367
37MP0005365_abnormal_bile_salt1.73949346
38MP0005310_abnormal_salivary_gland1.73028561
39MP0003566_abnormal_cell_adhesion1.70873756
40MP0004142_abnormal_muscle_tone1.69534040
41MP0005174_abnormal_tail_pigmentation1.66849414
42MP0010386_abnormal_urinary_bladder1.63667391
43MP0003191_abnormal_cellular_cholesterol1.63343302
44MP0001486_abnormal_startle_reflex1.62881226
45MP0003091_abnormal_cell_migration1.62381593
46MP0009745_abnormal_behavioral_response1.61657820
47MP0003890_abnormal_embryonic-extraembry1.60168200
48MP0001986_abnormal_taste_sensitivity1.57151605
49MP0003172_abnormal_lysosome_physiology1.56414830
50MP0005386_behavior/neurological_phenoty1.55363624
51MP0004924_abnormal_behavior1.55363624
52MP0005058_abnormal_lysosome_morphology1.51287882
53MP0003690_abnormal_glial_cell1.50224044
54MP0004145_abnormal_muscle_electrophysio1.48401160
55MP0003329_amyloid_beta_deposits1.48277529
56MP0004858_abnormal_nervous_system1.47474600
57MP0002735_abnormal_chemical_nociception1.47309642
58MP0010234_abnormal_vibrissa_follicle1.46846129
59MP0009780_abnormal_chondrocyte_physiolo1.42904537
60MP0002736_abnormal_nociception_after1.42889160
61MP0002089_abnormal_postnatal_growth/wei1.42721801
62MP0003279_aneurysm1.41989941
63MP0005623_abnormal_meninges_morphology1.41743689
64MP0002064_seizures1.39699859
65MP0004947_skin_inflammation1.38175873
66MP0005387_immune_system_phenotype1.37651221
67MP0001790_abnormal_immune_system1.37651221
68MP0005464_abnormal_platelet_physiology1.37343588
69MP0001485_abnormal_pinna_reflex1.36461490
70MP0002009_preneoplasia1.36115946
71MP0005253_abnormal_eye_physiology1.35726790
72MP0002837_dystrophic_cardiac_calcinosis1.34304490
73MP0001984_abnormal_olfaction1.32741260
74MP0005397_hematopoietic_system_phenotyp1.32589003
75MP0001545_abnormal_hematopoietic_system1.32589003
76MP0002067_abnormal_sensory_capabilities1.31348116
77MP0002272_abnormal_nervous_system1.30566148
78MP0000631_abnormal_neuroendocrine_gland1.29642268
79MP0002166_altered_tumor_susceptibility1.29566220
80MP0006276_abnormal_autonomic_nervous1.28232557
81MP0010678_abnormal_skin_adnexa1.27091123
82MP0001800_abnormal_humoral_immune1.26337081
83MP0004808_abnormal_hematopoietic_stem1.26000175
84MP0001873_stomach_inflammation1.24986861
85MP0002419_abnormal_innate_immunity1.22647269
86MP0002572_abnormal_emotion/affect_behav1.22140920
87MP0005023_abnormal_wound_healing1.21850961
88MP0005266_abnormal_metabolism1.21437454
89MP0002254_reproductive_system_inflammat1.19603287
90MP0003787_abnormal_imprinting1.19314353
91MP0010352_gastrointestinal_tract_polyps1.18830535
92MP0002452_abnormal_antigen_presenting1.18800301
93MP0003763_abnormal_thymus_physiology1.16159236
94MP0002876_abnormal_thyroid_physiology1.16044296
95MP0003950_abnormal_plasma_membrane1.15913946
96MP0003075_altered_response_to1.15174462
97MP0001533_abnormal_skeleton_physiology1.12340586
98MP0000733_abnormal_muscle_development1.12328768
99MP0000609_abnormal_liver_physiology1.11880534
100MP0002168_other_aberrant_phenotype1.11061405
101MP0002928_abnormal_bile_duct1.11044714
102MP0002557_abnormal_social/conspecific_i1.10515572
103MP0005166_decreased_susceptibility_to1.09099091
104MP0002063_abnormal_learning/memory/cond1.09019609
105MP0005645_abnormal_hypothalamus_physiol1.08326192
106MP0001970_abnormal_pain_threshold1.06996509
107MP0005670_abnormal_white_adipose1.06151228
108MP0003183_abnormal_peptide_metabolism1.05556596
109MP0002733_abnormal_thermal_nociception1.04632903
110MP0005000_abnormal_immune_tolerance1.04579160
111MP0002723_abnormal_immune_serum1.03548033
112MP0008872_abnormal_physiological_respon1.01902444
113MP0003633_abnormal_nervous_system0.99065299
114MP0000371_diluted_coat_color0.98239708
115MP0003136_yellow_coat_color0.97963506
116MP0002420_abnormal_adaptive_immunity0.95903402
117MP0001819_abnormal_immune_cell0.95891024
118MP0002102_abnormal_ear_morphology0.95654345
119MP0000230_abnormal_systemic_arterial0.94697183
120MP0002998_abnormal_bone_remodeling0.93609504
121MP0000778_abnormal_nervous_system0.93308063
122MP0002933_joint_inflammation0.93124052
123MP0002118_abnormal_lipid_homeostasis0.92223865
124MP0005647_abnormal_sex_gland0.91761745
125MP0002909_abnormal_adrenal_gland0.91349804
126MP0001324_abnormal_eye_pigmentation0.89408014
127MP0002229_neurodegeneration0.88978943
128MP0002095_abnormal_skin_pigmentation0.87171516
129MP0002638_abnormal_pupillary_reflex0.86432090
130MP0000538_abnormal_urinary_bladder0.86358478
131MP0004133_heterotaxia0.86191934
132MP0010307_abnormal_tumor_latency0.85151422
133MP0000751_myopathy0.85082472
134MP0003632_abnormal_nervous_system0.84907946
135MP0010155_abnormal_intestine_physiology0.84699217
136MP0005025_abnormal_response_to0.84446817
137MP0004381_abnormal_hair_follicle0.83299803
138MP0000767_abnormal_smooth_muscle0.83062025
139MP0005275_abnormal_skin_tensile0.81997236
140MP0005085_abnormal_gallbladder_physiolo0.81265489
141MP0003115_abnormal_respiratory_system0.81088310
142MP0000015_abnormal_ear_pigmentation0.80933957
143MP0000470_abnormal_stomach_morphology0.80268657
144MP0005187_abnormal_penis_morphology0.79610398
145MP0001845_abnormal_inflammatory_respons0.79311477
146MP0002734_abnormal_mechanical_nocicepti0.78877379
147MP0008469_abnormal_protein_level0.75764191
148MP0005195_abnormal_posterior_eye0.75742389
149MP0003698_abnormal_male_reproductive0.75486515
150MP0004215_abnormal_myocardial_fiber0.75196610
151MP0001440_abnormal_grooming_behavior0.75131514
152MP0002398_abnormal_bone_marrow0.75119772
153MP0003937_abnormal_limbs/digits/tail_de0.74779090
154MP0002882_abnormal_neuron_morphology0.74607857
155MP0002006_tumorigenesis0.74493637
156MP0003879_abnormal_hair_cell0.74362828
157MP0006082_CNS_inflammation0.74111531
158MP0000716_abnormal_immune_system0.73783286
159MP0003943_abnormal_hepatobiliary_system0.73570936
160MP0005448_abnormal_energy_balance0.72701109
161MP0000955_abnormal_spinal_cord0.72036915
162MP0005666_abnormal_adipose_tissue0.71593761
163MP0004742_abnormal_vestibular_system0.71585379
164MP0005083_abnormal_biliary_tract0.71246765
165MP0004885_abnormal_endolymph0.71041041
166MP0002332_abnormal_exercise_endurance0.70179449
167MP0003635_abnormal_synaptic_transmissio0.69048701
168MP0003448_altered_tumor_morphology0.68834123
169MP0005389_reproductive_system_phenotype0.68658413
170MP0002405_respiratory_system_inflammati0.68151390
171MP0001765_abnormal_ion_homeostasis0.68124435
172MP0002752_abnormal_somatic_nervous0.67896239
173MP0005584_abnormal_enzyme/coenzyme_acti0.67787445
174MP0002060_abnormal_skin_morphology0.67072745
175MP0000647_abnormal_sebaceous_gland0.66834603
176MP0003631_nervous_system_phenotype0.66634454
177MP0004147_increased_porphyrin_level0.66020477
178MP0009115_abnormal_fat_cell0.65752936
179MP0009763_increased_sensitivity_to0.65630276
180MP0002109_abnormal_limb_morphology0.65157781
181MP0005075_abnormal_melanosome_morpholog0.65081593
182MP0005377_hearing/vestibular/ear_phenot0.64644669
183MP0002138_abnormal_hepatobiliary_system0.64308646
184MP0008770_decreased_survivor_rate0.63434773
185MP0000249_abnormal_blood_vessel0.62562195

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.80387571
2Hyperventilation (HP:0002883)4.92371774
3Progressive cerebellar ataxia (HP:0002073)4.38237831
4Pancreatic cysts (HP:0001737)4.36288018
5Protruding tongue (HP:0010808)4.10402165
6Abnormality of the nasal mucosa (HP:0000433)4.00819878
7Hematochezia (HP:0002573)3.99628514
8Gaze-evoked nystagmus (HP:0000640)3.90397322
9Pancreatic fibrosis (HP:0100732)3.87857825
10Chronic hepatic failure (HP:0100626)3.86354682
11True hermaphroditism (HP:0010459)3.69345722
12Clumsiness (HP:0002312)3.65195173
13Spontaneous hematomas (HP:0007420)3.60834181
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.47813748
15Molar tooth sign on MRI (HP:0002419)3.42638281
16Abnormality of midbrain morphology (HP:0002418)3.42638281
17Nephronophthisis (HP:0000090)3.42528265
18Abnormality of the renal cortex (HP:0011035)3.35219650
19Aplasia/Hypoplasia of the tibia (HP:0005772)3.33119796
20Cerebral aneurysm (HP:0004944)3.29117170
21Abnormality of the renal medulla (HP:0100957)3.28459746
22Fair hair (HP:0002286)3.15895407
23Cystic liver disease (HP:0006706)3.07740480
24Nasal polyposis (HP:0100582)2.98197974
25Broad metatarsal (HP:0001783)2.95171430
26Aortic aneurysm (HP:0004942)2.94198363
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.86299129
28Hyperacusis (HP:0010780)2.86063417
29Medial flaring of the eyebrow (HP:0010747)2.85057285
30Febrile seizures (HP:0002373)2.81733226
31Conjunctival telangiectasia (HP:0000524)2.78856826
32Broad-based gait (HP:0002136)2.71128589
33Aneurysm (HP:0002617)2.71078854
34Urethral obstruction (HP:0000796)2.69603031
35Absent frontal sinuses (HP:0002688)2.66411171
36Mitral valve prolapse (HP:0001634)2.65754601
37Deep venous thrombosis (HP:0002625)2.64915163
38Absent speech (HP:0001344)2.63652111
39Tubular atrophy (HP:0000092)2.63408762
40Tubulointerstitial nephritis (HP:0001970)2.58121029
41Widely spaced teeth (HP:0000687)2.55392660
42Myocardial infarction (HP:0001658)2.53365690
43Congenital stationary night blindness (HP:0007642)2.52863929
44Attenuation of retinal blood vessels (HP:0007843)2.52554033
45Long toe (HP:0010511)2.51898656
46Generalized hypopigmentation of hair (HP:0011358)2.49874410
47Gait imbalance (HP:0002141)2.48483396
48Hypoplastic ischia (HP:0003175)2.44385009
49Macroorchidism (HP:0000053)2.40580067
50Congenital primary aphakia (HP:0007707)2.40222368
51Abnormality of the ischium (HP:0003174)2.39965900
52Abnormality of the lower motor neuron (HP:0002366)2.35143388
53Poor coordination (HP:0002370)2.34206522
54Striae distensae (HP:0001065)2.33863127
55Congenital hepatic fibrosis (HP:0002612)2.33468788
56Arterial tortuosity (HP:0005116)2.32935913
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.31611135
58Polycythemia (HP:0001901)2.30301931
59Renovascular hypertension (HP:0100817)2.29541618
60Protrusio acetabuli (HP:0003179)2.29311284
61Patellar aplasia (HP:0006443)2.28180804
62Turricephaly (HP:0000262)2.27701710
63Preaxial foot polydactyly (HP:0001841)2.27509468
64Genital tract atresia (HP:0001827)2.27167360
65Elfin facies (HP:0004428)2.26319193
66Systemic lupus erythematosus (HP:0002725)2.25072276
67Esophageal varix (HP:0002040)2.23474205
68Decreased circulating renin level (HP:0003351)2.23203020
69Volvulus (HP:0002580)2.20752176
70Distal upper limb amyotrophy (HP:0007149)2.20396901
71Upper limb amyotrophy (HP:0009129)2.20396901
72Truncal obesity (HP:0001956)2.19949411
73Vaginal atresia (HP:0000148)2.19756014
74Dialeptic seizures (HP:0011146)2.19104068
75Hypoplastic labia majora (HP:0000059)2.18521140
76Increased cerebral lipofuscin (HP:0011813)2.18053727
77Renal cortical cysts (HP:0000803)2.17265544
78Abnormality of the vasculature of the conjunctiva (HP:0008054)2.16779753
79Aortic dissection (HP:0002647)2.13525488
80Hemangiomatosis (HP:0007461)2.10701089
81Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.10464310
82Short foot (HP:0001773)2.10372395
83Heterotopia (HP:0002282)2.09733219
84Nephrogenic diabetes insipidus (HP:0009806)2.09337888
85Flat acetabular roof (HP:0003180)2.09201762
86Vascular tortuosity (HP:0004948)2.08675339
87Polydipsia (HP:0001959)2.06865172
88Abnormal drinking behavior (HP:0030082)2.06865172
89Aplasia/Hypoplasia of the patella (HP:0006498)2.04992047
90Abnormality of the labia majora (HP:0012881)2.04908860
91Drooling (HP:0002307)2.04331947
92Increased CSF protein (HP:0002922)2.04298136
93Urinary bladder sphincter dysfunction (HP:0002839)2.03616335
94Congenital sensorineural hearing impairment (HP:0008527)2.03157649
95Focal seizures (HP:0007359)2.02784748
96Visceral angiomatosis (HP:0100761)2.02512608
97Abnormality of the fingertips (HP:0001211)2.02118994
98Complement deficiency (HP:0004431)2.01027599
99Anencephaly (HP:0002323)2.00777092
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99780992
101Hand muscle atrophy (HP:0009130)1.99760544
102Xanthomatosis (HP:0000991)1.99640512
103Highly arched eyebrow (HP:0002553)1.98141512
104Furrowed tongue (HP:0000221)1.97476804
105Bony spicule pigmentary retinopathy (HP:0007737)1.97120444
106Postaxial foot polydactyly (HP:0001830)1.96761360
107Absence seizures (HP:0002121)1.96741327
108Mitral stenosis (HP:0001718)1.96689033
109Absent radius (HP:0003974)1.95915911
110Inability to walk (HP:0002540)1.95571096
111Stomach cancer (HP:0012126)1.95171425
112Preaxial hand polydactyly (HP:0001177)1.93173015
113Abolished electroretinogram (ERG) (HP:0000550)1.93159764
114Colitis (HP:0002583)1.92292360
115Supranuclear gaze palsy (HP:0000605)1.92086408
116Oligodactyly (hands) (HP:0001180)1.91925888
117Insomnia (HP:0100785)1.91500779
118Dilatation of the ascending aorta (HP:0005111)1.91417593
119Absent forearm bone (HP:0003953)1.90992972
120Aplasia involving forearm bones (HP:0009822)1.90992972
121Stroke (HP:0001297)1.90940830
122Central scotoma (HP:0000603)1.90738792
123Global brain atrophy (HP:0002283)1.90494899
124Shallow orbits (HP:0000586)1.88696547
125Tented upper lip vermilion (HP:0010804)1.88353895
126Large for gestational age (HP:0001520)1.87246540
127Gastrointestinal inflammation (HP:0004386)1.86692159
128Macroglossia (HP:0000158)1.86169350
129Inflammation of the large intestine (HP:0002037)1.85839436
130Hyperkalemia (HP:0002153)1.85641331
131Excessive salivation (HP:0003781)1.85522500
132Bladder diverticulum (HP:0000015)1.85200543
133Clubbing of toes (HP:0100760)1.84024152
134Abnormality of the nasal septum (HP:0000419)1.82280499
135Increased density of long bones (HP:0006392)1.81902417
136Dysmetric saccades (HP:0000641)1.81711672
137Abnormality of the renal collecting system (HP:0004742)1.81562316
138Spondylolisthesis (HP:0003302)1.80910495
139Hypoplastic iliac wings (HP:0002866)1.80700548
140Abnormality of binocular vision (HP:0011514)1.80160841
141Diplopia (HP:0000651)1.80160841
142Lower limb amyotrophy (HP:0007210)1.80132979
143Tubulointerstitial abnormality (HP:0001969)1.79898568
144Gingival bleeding (HP:0000225)1.79734475
145Sclerocornea (HP:0000647)1.79487373
146Hemiplegia (HP:0002301)1.78603362
147Buphthalmos (HP:0000557)1.78595139
148Abnormal biliary tract physiology (HP:0012439)1.78077356
149Bile duct proliferation (HP:0001408)1.78077356
150Cupped ear (HP:0000378)1.77301435
151Disinhibition (HP:0000734)1.76437281
152Abnormality of complement system (HP:0005339)1.75900965
153Short chin (HP:0000331)1.75351418
154Impaired smooth pursuit (HP:0007772)1.75015866
155Duplicated collecting system (HP:0000081)1.74933746
156Cerebellar dysplasia (HP:0007033)1.73361176
157Thin bony cortex (HP:0002753)1.73200501
158Ectopic kidney (HP:0000086)1.72078244
159Abnormality of the pubic bones (HP:0003172)1.70843907
160Neuronal loss in central nervous system (HP:0002529)1.70762690
161Cerebral inclusion bodies (HP:0100314)1.68445448
162Bowel diverticulosis (HP:0005222)1.68126040
163Bulbous nose (HP:0000414)1.68070993
164Disproportionate tall stature (HP:0001519)1.67535767
165Recurrent bronchitis (HP:0002837)1.67438628
166Hypercholesterolemia (HP:0003124)1.67309521
167Arachnodactyly (HP:0001166)1.66076461
168Genu recurvatum (HP:0002816)1.63623561
169Epidermoid cyst (HP:0200040)1.62489673
170Interstitial pulmonary disease (HP:0006530)1.62131187
171Frequent falls (HP:0002359)1.61561272
172Recurrent viral infections (HP:0004429)1.60585984
173Pulmonary embolism (HP:0002204)1.60158041
174Overriding aorta (HP:0002623)1.59466719
175Abnormality of the Achilles tendon (HP:0005109)1.58467890
176Renal duplication (HP:0000075)1.57945128
177Difficulty running (HP:0009046)1.57079019
178Eczematoid dermatitis (HP:0000976)1.55386328
179Radial bowing (HP:0002986)1.54438723
180Narrow palate (HP:0000189)1.53547441
181Termporal pattern (HP:0011008)1.53209575
182Insidious onset (HP:0003587)1.53209575
183Recurrent fungal infections (HP:0002841)1.52119799
184Loss of speech (HP:0002371)1.51318936
185Arterial thrombosis (HP:0004420)1.51223815
186Male infertility (HP:0003251)1.50977596
187Peritonitis (HP:0002586)1.50656924
188Dynein arm defect of respiratory motile cilia (HP:0012255)1.50288063
189Absent/shortened dynein arms (HP:0200106)1.50288063
190Abnormal delayed hypersensitivity skin test (HP:0002963)1.49773597
191Achilles tendon contracture (HP:0001771)1.49038130
192Urinary urgency (HP:0000012)1.47507711
193Lymphangioma (HP:0100764)1.47496089
194Pointed chin (HP:0000307)1.47197300
195Hemorrhage of the eye (HP:0011885)1.46789080
196Increased variability in muscle fiber diameter (HP:0003557)1.45858979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.57447820
2TGFBR23.38149835
3ACVR1B3.34125654
4BMPR1B2.89311012
5MAP3K102.87757517
6AKT32.53549917
7MAP3K132.21692581
8ERN12.12486262
9PKN22.09986906
10DAPK22.09049451
11CASK2.04736336
12SIK12.01975241
13TGFBR11.99620678
14FGFR41.99565925
15EEF2K1.96951039
16RIPK11.92626306
17MAP4K11.92048270
18TTN1.86668269
19PTK61.80743182
20ICK1.73004370
21JAK11.72519805
22ADRBK21.71945875
23TYK21.60865519
24MKNK21.58167729
25JAK31.57614404
26CAMK1G1.55305605
27SIK21.53554247
28MAP3K71.53294769
29CAMK1D1.51926204
30MAP3K41.50507468
31EPHB11.49033841
32GRK11.45765378
33PRKD31.45474221
34MAPK131.45277272
35MAP3K141.44525595
36WNK31.44336419
37STK391.37276965
38CDK121.35595664
39PDGFRA1.34654792
40INSRR1.33635888
41OXSR11.32828471
42NUAK11.29924888
43MAP4K21.29714554
44NTRK31.29485169
45PTK2B1.27147602
46SGK21.24339957
47KIT1.23871061
48SCYL21.23583527
49RIPK41.22478531
50CSF1R1.21585078
51TBK11.17645094
52FGFR31.16534822
53PDGFRB1.13350437
54TXK1.11632616
55PDK41.10587190
56PDK31.10587190
57WNK41.09204212
58TNIK1.09112919
59PIK3CA1.07965113
60TRPM71.07712566
61ADRBK11.07403232
62TYRO31.06243581
63PIK3CG1.05940365
64RET1.04680373
65DDR21.04424907
66TEC1.04141448
67PRKCH1.03297055
68STK38L1.01810850
69NLK1.00187419
70MAP3K90.99784668
71HCK0.93415894
72PDK10.92014681
73PRPF4B0.88034235
74ZAK0.87808015
75FES0.87480639
76STK380.87130467
77PTK20.86259632
78EPHA40.86108278
79IKBKE0.85816911
80ZAP700.85500122
81CAMKK10.85241994
82MTOR0.83922032
83JAK20.83265078
84PNCK0.82979254
85PRKAA20.82760422
86LRRK20.82183197
87NTRK20.78304463
88PAK30.75768620
89SGK4940.74919246
90SGK2230.74919246
91PAK60.74667957
92BRSK20.73695354
93BLK0.73063137
94EPHA30.72998675
95BMX0.71872151
96TAOK30.71783406
97ALK0.69095744
98MARK20.68001274
99CAMK40.67345056
100CSK0.66859333
101LMTK20.66663129
102WNK10.66405763
103FGR0.65900332
104PDPK10.65500960
105MARK10.64311806
106STK30.63899646
107CAMK10.63707380
108BRD40.63227298
109FGFR20.62977449
110CAMKK20.62617026
111OBSCN0.62542575
112PINK10.62514678
113PRKCE0.61794469
114STK110.61287776
115SGK30.59276658
116CHUK0.58717003
117KSR20.58130023
118PRKAA10.57618360
119ERBB20.56320285
120FRK0.54838592
121GRK60.54676863
122SGK10.54063049
123RPS6KA20.53546316
124EGFR0.53533291
125ITK0.53373196
126PRKCQ0.53132464
127IRAK10.52700779
128CDK60.52202232
129PRKCG0.50687462
130FYN0.50670626
131DMPK0.50361327
132SYK0.50224829
133LCK0.50085141
134FER0.49550323
135TNK20.49547332
136CDC42BPA0.49020157
137MKNK10.48757568
138MAPK110.47489372
139LATS10.47291842
140TAOK10.46017202
141CSNK1A1L0.45961374
142MARK30.45702465
143MELK0.44807522
144TLK10.44492039
145TIE10.44080675
146PKN10.43485061
147MAP2K60.42463460
148RPS6KA40.41365996
149PAK20.41219951
150STK100.41026938
151GRK70.40414362
152SRC0.39994465
153PAK40.39679689
154CSNK1D0.39308865
155FGFR10.38864708
156PLK40.38452778
157CDK30.38281653
158MAP2K70.36927262
159RPS6KA60.36922520
160BTK0.36681280
161DYRK1A0.36035154
162IKBKB0.33245900
163RPS6KA30.33241202
164MAPK70.33001944
165PRKG10.32835501
166CAMK2A0.31813021
167GSK3B0.30842577
168MAPK80.29275700
169ATM0.28867511

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.41354208
2Nitrogen metabolism_Homo sapiens_hsa009102.25691698
3Phototransduction_Homo sapiens_hsa047441.97493159
4Taste transduction_Homo sapiens_hsa047421.86271302
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80077778
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74504523
7Linoleic acid metabolism_Homo sapiens_hsa005911.73499834
8Butanoate metabolism_Homo sapiens_hsa006501.70056091
9Morphine addiction_Homo sapiens_hsa050321.62399319
10B cell receptor signaling pathway_Homo sapiens_hsa046621.57394454
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52451134
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52363036
13Tryptophan metabolism_Homo sapiens_hsa003801.51734541
14Calcium signaling pathway_Homo sapiens_hsa040201.44080917
15Staphylococcus aureus infection_Homo sapiens_hsa051501.43691118
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.39793417
17Osteoclast differentiation_Homo sapiens_hsa043801.38158993
18Type II diabetes mellitus_Homo sapiens_hsa049301.34970084
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34219496
20Ether lipid metabolism_Homo sapiens_hsa005651.34092525
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.33758781
22Fanconi anemia pathway_Homo sapiens_hsa034601.32069284
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30487597
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30318717
25Homologous recombination_Homo sapiens_hsa034401.29679742
26Serotonergic synapse_Homo sapiens_hsa047261.26960010
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26583586
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.26208606
29Complement and coagulation cascades_Homo sapiens_hsa046101.25886213
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22095168
31Histidine metabolism_Homo sapiens_hsa003401.21881382
32Insulin secretion_Homo sapiens_hsa049111.21849379
33Chronic myeloid leukemia_Homo sapiens_hsa052201.21263066
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20892219
35Bile secretion_Homo sapiens_hsa049761.19257372
36GABAergic synapse_Homo sapiens_hsa047271.19256192
37Insulin resistance_Homo sapiens_hsa049311.18096766
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17326985
39Fatty acid biosynthesis_Homo sapiens_hsa000611.16358284
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15285715
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15129611
42Toxoplasmosis_Homo sapiens_hsa051451.12302397
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11961237
44Circadian rhythm_Homo sapiens_hsa047101.09346490
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.09101068
46PPAR signaling pathway_Homo sapiens_hsa033201.09015944
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07151225
48Ovarian steroidogenesis_Homo sapiens_hsa049131.05547914
49T cell receptor signaling pathway_Homo sapiens_hsa046601.04924862
50ABC transporters_Homo sapiens_hsa020101.04577983
51Lysine degradation_Homo sapiens_hsa003101.04562020
52VEGF signaling pathway_Homo sapiens_hsa043701.04073927
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03766066
54Glioma_Homo sapiens_hsa052141.03295778
55Dorso-ventral axis formation_Homo sapiens_hsa043201.03291972
56Arginine biosynthesis_Homo sapiens_hsa002201.01840519
57Acute myeloid leukemia_Homo sapiens_hsa052210.99584593
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98129553
59Estrogen signaling pathway_Homo sapiens_hsa049150.95346909
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94377518
61Non-small cell lung cancer_Homo sapiens_hsa052230.93527302
62Long-term depression_Homo sapiens_hsa047300.92894259
63Amoebiasis_Homo sapiens_hsa051460.92312781
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91607047
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91294153
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90863570
67mTOR signaling pathway_Homo sapiens_hsa041500.90850528
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.90798505
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.89625627
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89271337
71Leishmaniasis_Homo sapiens_hsa051400.88411062
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87290893
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87138305
74Graft-versus-host disease_Homo sapiens_hsa053320.86553679
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85867966
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85865351
77Focal adhesion_Homo sapiens_hsa045100.85839229
78Pancreatic cancer_Homo sapiens_hsa052120.84214287
79Platelet activation_Homo sapiens_hsa046110.84089604
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.83637288
81Prolactin signaling pathway_Homo sapiens_hsa049170.83029075
82Proteoglycans in cancer_Homo sapiens_hsa052050.82639913
83Small cell lung cancer_Homo sapiens_hsa052220.82604706
84Caffeine metabolism_Homo sapiens_hsa002320.81672878
85Renin secretion_Homo sapiens_hsa049240.81556447
86Salivary secretion_Homo sapiens_hsa049700.80451381
87Inositol phosphate metabolism_Homo sapiens_hsa005620.80432938
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78932527
89Chemical carcinogenesis_Homo sapiens_hsa052040.77574685
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77520528
91Retinol metabolism_Homo sapiens_hsa008300.76931045
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.75890454
93Selenocompound metabolism_Homo sapiens_hsa004500.75500828
94Gastric acid secretion_Homo sapiens_hsa049710.74665193
95FoxO signaling pathway_Homo sapiens_hsa040680.74000294
96Glucagon signaling pathway_Homo sapiens_hsa049220.73054022
97Dopaminergic synapse_Homo sapiens_hsa047280.72734822
98Insulin signaling pathway_Homo sapiens_hsa049100.72092066
99Circadian entrainment_Homo sapiens_hsa047130.71304666
100TNF signaling pathway_Homo sapiens_hsa046680.70849174
101Chemokine signaling pathway_Homo sapiens_hsa040620.70544799
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70257480
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70134153
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.70105211
105ECM-receptor interaction_Homo sapiens_hsa045120.69328456
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.69238808
107Measles_Homo sapiens_hsa051620.69202721
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68849001
109Pancreatic secretion_Homo sapiens_hsa049720.68846705
110Influenza A_Homo sapiens_hsa051640.68373064
111Oxytocin signaling pathway_Homo sapiens_hsa049210.67807291
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67331220
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.66713101
114beta-Alanine metabolism_Homo sapiens_hsa004100.64788424
115Hepatitis B_Homo sapiens_hsa051610.63912778
116Regulation of autophagy_Homo sapiens_hsa041400.63464535
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63154286
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62890342
119Long-term potentiation_Homo sapiens_hsa047200.62833150
120Olfactory transduction_Homo sapiens_hsa047400.62283109
121ErbB signaling pathway_Homo sapiens_hsa040120.61665100
122GnRH signaling pathway_Homo sapiens_hsa049120.60883042
123Shigellosis_Homo sapiens_hsa051310.60733331
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.60676931
125Tuberculosis_Homo sapiens_hsa051520.60555310
126Rap1 signaling pathway_Homo sapiens_hsa040150.60461938
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60423544
128AMPK signaling pathway_Homo sapiens_hsa041520.59871828
129MAPK signaling pathway_Homo sapiens_hsa040100.58988445
130Glycerolipid metabolism_Homo sapiens_hsa005610.58045334
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57563555
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57543635
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57275042
134TGF-beta signaling pathway_Homo sapiens_hsa043500.57150167
135cAMP signaling pathway_Homo sapiens_hsa040240.56996069
136Cholinergic synapse_Homo sapiens_hsa047250.56573767
137Choline metabolism in cancer_Homo sapiens_hsa052310.55812666
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.55568280
139Endometrial cancer_Homo sapiens_hsa052130.55528433
140Endocytosis_Homo sapiens_hsa041440.55385302
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54962082
142Glutamatergic synapse_Homo sapiens_hsa047240.54920170
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54607159
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.53836941
145Ras signaling pathway_Homo sapiens_hsa040140.53656002
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52679006
147Fatty acid metabolism_Homo sapiens_hsa012120.52209242
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51917221
149Dilated cardiomyopathy_Homo sapiens_hsa054140.51521013
150Fatty acid degradation_Homo sapiens_hsa000710.51468793
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51424005
152Sphingolipid metabolism_Homo sapiens_hsa006000.50641970
153Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50472493
154Propanoate metabolism_Homo sapiens_hsa006400.47882820
155Cocaine addiction_Homo sapiens_hsa050300.47434842
156Asthma_Homo sapiens_hsa053100.47345953
157Arachidonic acid metabolism_Homo sapiens_hsa005900.43862169
158Amphetamine addiction_Homo sapiens_hsa050310.42585732
159Basal transcription factors_Homo sapiens_hsa030220.42011126
160Axon guidance_Homo sapiens_hsa043600.39236229
161NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38943757
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38769628
163MicroRNAs in cancer_Homo sapiens_hsa052060.38439779

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