ATPAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 beta subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. Alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.18702104
2regulation of translational termination (GO:0006449)4.75736473
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.55340661
4tricarboxylic acid cycle (GO:0006099)4.50910708
5ATP synthesis coupled proton transport (GO:0015986)4.48159783
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.48159783
7synaptic vesicle maturation (GO:0016188)4.33918210
8oxidative phosphorylation (GO:0006119)4.31196221
9regulation of acyl-CoA biosynthetic process (GO:0050812)4.31076119
10regulation of coenzyme metabolic process (GO:0051196)4.25889106
11regulation of cofactor metabolic process (GO:0051193)4.25889106
12creatine metabolic process (GO:0006600)4.21020984
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.19354256
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.19149753
15neuronal action potential propagation (GO:0019227)4.07312043
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.02523073
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.96394137
18respiratory electron transport chain (GO:0022904)3.86341467
19actin-mediated cell contraction (GO:0070252)3.81218700
20negative regulation of potassium ion transmembrane transport (GO:1901380)3.80823876
21regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.76917085
22electron transport chain (GO:0022900)3.76229962
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69654026
24cell communication by electrical coupling (GO:0010644)3.67721180
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.60857280
26regulation of sulfur metabolic process (GO:0042762)3.60251070
27cardiac muscle contraction (GO:0060048)3.57981994
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53935995
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.50330549
30glutamate secretion (GO:0014047)3.49427574
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.48211770
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.38404990
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37672745
34cardiac muscle hypertrophy (GO:0003300)3.35775581
35neuromuscular process controlling posture (GO:0050884)3.35693458
36regulation of cell communication by electrical coupling (GO:0010649)3.35170252
37locomotory exploration behavior (GO:0035641)3.31392193
38NADH metabolic process (GO:0006734)3.31332295
39cell communication involved in cardiac conduction (GO:0086065)3.30840007
40striated muscle hypertrophy (GO:0014897)3.29051461
41skeletal muscle contraction (GO:0003009)3.24279010
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22952428
43synaptic vesicle exocytosis (GO:0016079)3.21336229
44cardiac myofibril assembly (GO:0055003)3.15045928
45regulation of membrane repolarization (GO:0060306)3.11890064
46regulation of synapse structural plasticity (GO:0051823)3.09122635
47gluconeogenesis (GO:0006094)3.08400529
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05527810
49oxaloacetate metabolic process (GO:0006107)3.03726548
50response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.03177353
51regulation of relaxation of muscle (GO:1901077)2.98238882
52ventricular cardiac muscle cell action potential (GO:0086005)2.91901438
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91838652
54regulation of mitochondrial translation (GO:0070129)2.90214186
55cardiac muscle cell action potential involved in contraction (GO:0086002)2.90189796
56regulation of synaptic vesicle exocytosis (GO:2000300)2.89875653
57ATP biosynthetic process (GO:0006754)2.89611399
58regulation of synaptic vesicle transport (GO:1902803)2.87677319
59cardiac muscle hypertrophy in response to stress (GO:0014898)2.84012283
60muscle hypertrophy in response to stress (GO:0003299)2.84012283
61cardiac muscle adaptation (GO:0014887)2.84012283
62sodium ion export (GO:0071436)2.83743584
63neurotransmitter secretion (GO:0007269)2.83289444
64cardiac muscle cell action potential (GO:0086001)2.82198619
65regulation of cellular respiration (GO:0043457)2.82011741
66carnitine shuttle (GO:0006853)2.81107611
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80595629
68synaptic vesicle docking involved in exocytosis (GO:0016081)2.79971230
69succinate metabolic process (GO:0006105)2.79717241
70regulation of skeletal muscle contraction (GO:0014819)2.79561278
71regulation of calcium ion transmembrane transporter activity (GO:1901019)2.78230986
72regulation of calcium ion transmembrane transport (GO:1903169)2.78230986
73glycogen catabolic process (GO:0005980)2.78057124
74sarcomere organization (GO:0045214)2.76999956
75positive regulation of potassium ion transmembrane transport (GO:1901381)2.76887467
76cellular potassium ion homeostasis (GO:0030007)2.76836687
77DNA deamination (GO:0045006)2.76284232
78peptidyl-lysine dimethylation (GO:0018027)2.74317728
79actin filament-based movement (GO:0030048)2.74222792
80hexose biosynthetic process (GO:0019319)2.74165895
812-oxoglutarate metabolic process (GO:0006103)2.73389693
82positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.72874834
83actomyosin structure organization (GO:0031032)2.71977419
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.70506825
85muscle hypertrophy (GO:0014896)2.70472479
86cerebellar granule cell differentiation (GO:0021707)2.70372001
87sarcoplasmic reticulum calcium ion transport (GO:0070296)2.69184160
88striated muscle contraction (GO:0006941)2.66227237
89inner mitochondrial membrane organization (GO:0007007)2.64857376
90quinone biosynthetic process (GO:1901663)2.64697405
91ubiquinone biosynthetic process (GO:0006744)2.64697405
92establishment of protein localization to mitochondrion (GO:0072655)2.63722712
93protein localization to mitochondrion (GO:0070585)2.62890241
94chaperone-mediated protein complex assembly (GO:0051131)2.62294252
95plasma membrane repair (GO:0001778)2.61758292
96purine nucleoside monophosphate biosynthetic process (GO:0009127)2.61559046
97purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.61559046
98regulation of sodium ion transmembrane transporter activity (GO:2000649)2.59933338
99detection of calcium ion (GO:0005513)2.59932751
100activation of protein kinase A activity (GO:0034199)2.59392757
101regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59091461
102cardiac muscle cell development (GO:0055013)2.58722778
103purine nucleobase biosynthetic process (GO:0009113)2.57207762
104muscle contraction (GO:0006936)2.56439529
105regulation of neuronal synaptic plasticity (GO:0048168)2.55081530
106potassium ion import (GO:0010107)2.54942071
107regulation of voltage-gated calcium channel activity (GO:1901385)2.53882210
108positive regulation of synapse maturation (GO:0090129)2.53767577
109myofibril assembly (GO:0030239)2.53389663
110striatum development (GO:0021756)2.52994766
111peptidyl-arginine omega-N-methylation (GO:0035247)2.51624077
112glucan catabolic process (GO:0009251)2.51461097
113response to parathyroid hormone (GO:0071107)2.50961832
114protein localization to kinetochore (GO:0034501)2.50889157
115regulation of actin filament-based movement (GO:1903115)2.50438150
116adult heart development (GO:0007512)2.50185607
117regulation of cardiac muscle cell contraction (GO:0086004)2.48786385
118regulation of sodium ion transmembrane transport (GO:1902305)2.48394411
119glycogen biosynthetic process (GO:0005978)2.48389545
120glucan biosynthetic process (GO:0009250)2.48389545
121exploration behavior (GO:0035640)2.46264496
122negative regulation of organelle assembly (GO:1902116)2.45646217
123membrane depolarization during action potential (GO:0086010)2.45450844
124protein targeting to mitochondrion (GO:0006626)2.45213759
125aspartate family amino acid catabolic process (GO:0009068)2.44206502
126regulation of glutamate receptor signaling pathway (GO:1900449)2.44031776
127mitochondrial fusion (GO:0008053)2.41545662
128ventricular cardiac muscle cell development (GO:0055015)2.41320969
129paraxial mesoderm development (GO:0048339)2.41203881
130cellular sodium ion homeostasis (GO:0006883)2.41020291
131fatty acid homeostasis (GO:0055089)2.40943814
132muscle filament sliding (GO:0030049)2.40843906
133actin-myosin filament sliding (GO:0033275)2.40843906
134gonadal mesoderm development (GO:0007506)2.39993424
135respiratory system process (GO:0003016)2.39112546
136cardiac muscle tissue morphogenesis (GO:0055008)2.38970515
137regulation of NFAT protein import into nucleus (GO:0051532)2.38119205
138monosaccharide biosynthetic process (GO:0046364)2.35908608
139dicarboxylic acid biosynthetic process (GO:0043650)2.35651067
140DNA unwinding involved in DNA replication (GO:0006268)2.34206481
141fatty acid transmembrane transport (GO:1902001)2.33987361
142skeletal muscle fiber development (GO:0048741)2.33922290
143regulation of the force of heart contraction (GO:0002026)2.33876183
144negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.32510534
145negative regulation of calcium ion transmembrane transport (GO:1903170)2.32510534
146muscle tissue morphogenesis (GO:0060415)2.32258907
147muscle system process (GO:0003012)2.28050769
148mitotic chromosome condensation (GO:0007076)2.26694536
149neuronal ion channel clustering (GO:0045161)2.25348436
150potassium ion homeostasis (GO:0055075)2.24965451
151muscle cell fate commitment (GO:0042693)2.24560376
152IMP metabolic process (GO:0046040)2.24280568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.90957729
2E2F7_22180533_ChIP-Seq_HELA_Human4.27794025
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.20615422
4EZH2_22144423_ChIP-Seq_EOC_Human4.13107922
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.76074849
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.55132243
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16233429
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.75328831
9THAP11_20581084_ChIP-Seq_MESCs_Mouse2.74579200
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62893318
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52414359
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51199449
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.47810670
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40311291
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30429226
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22260588
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22174950
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19008031
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.16216747
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.15455437
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15167261
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11206058
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08469521
24ZNF263_19887448_ChIP-Seq_K562_Human2.02392827
25AR_21909140_ChIP-Seq_LNCAP_Human1.98745060
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91675189
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90433151
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.89576119
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87682807
30XRN2_22483619_ChIP-Seq_HELA_Human1.85706430
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.83874949
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81064139
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81064139
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80814997
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80026488
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79642345
37CLOCK_20551151_ChIP-Seq_293T_Human1.76255483
38* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76009960
39ZNF274_21170338_ChIP-Seq_K562_Hela1.75280668
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74126909
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72945508
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.71364046
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71026775
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.70060418
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61065296
46* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59957464
47DCP1A_22483619_ChIP-Seq_HELA_Human1.58259402
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57684857
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56023443
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.54893270
51REST_21632747_ChIP-Seq_MESCs_Mouse1.52247983
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51394994
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44540661
54SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.43129200
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39550582
56TTF2_22483619_ChIP-Seq_HELA_Human1.38093321
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.37738548
58* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.37510652
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35818155
60* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35452491
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35331076
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34668146
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34580308
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.34164940
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.34164940
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.34092596
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33378031
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32635289
69CIITA_25753668_ChIP-Seq_RAJI_Human1.32339112
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30951941
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.30341913
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29479472
73KDM2B_26808549_Chip-Seq_K562_Human1.29382055
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.28432138
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28212325
76VDR_23849224_ChIP-Seq_CD4+_Human1.28143826
77GABP_19822575_ChIP-Seq_HepG2_Human1.28017539
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27141865
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25544562
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25050510
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23742923
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23522952
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22967671
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21821405
85* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21562531
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21453354
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19921598
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18768452
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17326080
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.17007828
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16940920
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.16091793
93FOXP3_21729870_ChIP-Seq_TREG_Human1.16044670
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15101127
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14407418
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13781164
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.12775398
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.12562295
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11029180
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.10993426
101CTCF_27219007_Chip-Seq_Bcells_Human1.10499012
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09775406
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09291112
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08827059
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.08650330
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07318877
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06832136
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06410432
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05501424
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05299388
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.04704249
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02734366
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02679609
114ELK1_19687146_ChIP-ChIP_HELA_Human1.02543486
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02497850
116* TET1_21490601_ChIP-Seq_MESCs_Mouse1.02092560
117KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01994123
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01576091
119SOX9_26525672_Chip-Seq_HEART_Mouse1.01425113
120CREB1_26743006_Chip-Seq_LNCaP_Human1.00438810
121RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00304908
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00140900
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99699585
124DROSHA_22980978_ChIP-Seq_HELA_Human0.99660290
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98829777
126RING1B_27294783_Chip-Seq_ESCs_Mouse0.98383097
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97902198
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97849231
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96978291
130RNF2_27304074_Chip-Seq_NSC_Mouse0.96965826
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96910878
132SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96423677
133SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96013368
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.94662603
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94214856
136* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93837338
137ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93471502
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92308971
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92111359
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91969012
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.87563244
142NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86074068
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85267790
144FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85081642
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84274751
146FOXP1_21924763_ChIP-Seq_HESCs_Human0.82868381
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82208723
148CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81964966
149* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81367004
150* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80777747
151GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80387265
152OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80114256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.68010382
2MP0003880_abnormal_central_pattern4.22784626
3MP0003646_muscle_fatigue3.52054983
4MP0004215_abnormal_myocardial_fiber3.50093295
5MP0004084_abnormal_cardiac_muscle3.29874366
6MP0000751_myopathy3.22465808
7MP0002837_dystrophic_cardiac_calcinosis2.95118706
8MP0003635_abnormal_synaptic_transmissio2.78371407
9MP0000749_muscle_degeneration2.70297618
10MP0004036_abnormal_muscle_relaxation2.58278989
11MP0002822_catalepsy2.50885458
12MP0005330_cardiomyopathy2.42868508
13MP0004145_abnormal_muscle_electrophysio2.41046333
14MP0006036_abnormal_mitochondrial_physio2.31354435
15MP0003123_paternal_imprinting2.27682512
16MP0000747_muscle_weakness2.21509009
17MP0004270_analgesia2.08320093
18MP0002064_seizures2.06838826
19MP0003137_abnormal_impulse_conducting2.06424182
20MP0006035_abnormal_mitochondrial_morpho2.05036028
21MP0009046_muscle_twitch2.01952897
22MP0009745_abnormal_behavioral_response1.99311953
23MP0002269_muscular_atrophy1.97805372
24MP0005670_abnormal_white_adipose1.88138231
25MP0002063_abnormal_learning/memory/cond1.87466986
26MP0002272_abnormal_nervous_system1.85569152
27MP0004484_altered_response_of1.78456660
28MP0004087_abnormal_muscle_fiber1.77415275
29MP0003221_abnormal_cardiomyocyte_apopto1.68339888
30MP0001486_abnormal_startle_reflex1.66396818
31MP0004957_abnormal_blastocyst_morpholog1.64805437
32MP0001529_abnormal_vocalization1.61009251
33MP0004130_abnormal_muscle_cell1.59491868
34MP0002106_abnormal_muscle_physiology1.59037928
35MP0005620_abnormal_muscle_contractility1.54811528
36MP0001346_abnormal_lacrimal_gland1.52372178
37MP0004233_abnormal_muscle_weight1.50709195
38MP0002972_abnormal_cardiac_muscle1.50676249
39MP0010094_abnormal_chromosome_stability1.49984750
40MP0009672_abnormal_birth_weight1.49078331
41MP0000566_synostosis1.47472884
42MP0002909_abnormal_adrenal_gland1.45416580
43MP0001968_abnormal_touch/_nociception1.43915059
44MP0005386_behavior/neurological_phenoty1.43551441
45MP0004924_abnormal_behavior1.43551441
46MP0002572_abnormal_emotion/affect_behav1.42249426
47MP0001544_abnormal_cardiovascular_syste1.41210432
48MP0005385_cardiovascular_system_phenoty1.41210432
49MP0004142_abnormal_muscle_tone1.41112269
50MP0004147_increased_porphyrin_level1.41011264
51MP0001661_extended_life_span1.40686385
52MP0009780_abnormal_chondrocyte_physiolo1.36797469
53MP0004085_abnormal_heartbeat1.36460722
54MP0002067_abnormal_sensory_capabilities1.35773824
55MP0003693_abnormal_embryo_hatching1.33398606
56MP0008775_abnormal_heart_ventricle1.31414024
57MP0005409_darkened_coat_color1.29671990
58MP0000759_abnormal_skeletal_muscle1.29340076
59MP0005623_abnormal_meninges_morphology1.28497700
60MP0006138_congestive_heart_failure1.27932290
61MP0001440_abnormal_grooming_behavior1.27759882
62MP0010630_abnormal_cardiac_muscle1.25762289
63MP0005369_muscle_phenotype1.23509432
64MP0003111_abnormal_nucleus_morphology1.22298540
65MP0005451_abnormal_body_composition1.21642681
66MP0005423_abnormal_somatic_nervous1.19225652
67MP0002734_abnormal_mechanical_nocicepti1.19189088
68MP0004043_abnormal_pH_regulation1.19155686
69MP0008569_lethality_at_weaning1.19099139
70MP0008877_abnormal_DNA_methylation1.17121006
71MP0002249_abnormal_larynx_morphology1.14063900
72MP0001188_hyperpigmentation1.13416031
73MP0010030_abnormal_orbit_morphology1.08332967
74MP0004811_abnormal_neuron_physiology1.06766586
75MP0003806_abnormal_nucleotide_metabolis1.06150952
76MP0005375_adipose_tissue_phenotype1.05877501
77MP0002066_abnormal_motor_capabilities/c1.05811064
78MP0003879_abnormal_hair_cell1.05739009
79MP0002971_abnormal_brown_adipose1.05309684
80MP0003567_abnormal_fetal_cardiomyocyte1.05204243
81MP0005187_abnormal_penis_morphology1.04344048
82MP0000778_abnormal_nervous_system1.02019934
83MP0001984_abnormal_olfaction1.01716682
84MP0000955_abnormal_spinal_cord1.00910371
85MP0000003_abnormal_adipose_tissue0.99830245
86MP0000733_abnormal_muscle_development0.99402329
87MP0005266_abnormal_metabolism0.98803045
88MP0002735_abnormal_chemical_nociception0.98452298
89MP0001970_abnormal_pain_threshold0.98137363
90MP0003077_abnormal_cell_cycle0.95706942
91MP0000750_abnormal_muscle_regeneration0.94809544
92MP0002736_abnormal_nociception_after0.94592441
93MP0003633_abnormal_nervous_system0.93950715
94MP0006276_abnormal_autonomic_nervous0.92449011
95MP0002733_abnormal_thermal_nociception0.91253725
96MP0001485_abnormal_pinna_reflex0.89901978
97MP0002234_abnormal_pharynx_morphology0.89332396
98MP0001299_abnormal_eye_distance/0.88817962
99MP0002108_abnormal_muscle_morphology0.88294272
100MP0009379_abnormal_foot_pigmentation0.87133495
101MP0003329_amyloid_beta_deposits0.84383107
102MP0008872_abnormal_physiological_respon0.84169796
103MP0008932_abnormal_embryonic_tissue0.83473812
104MP0001501_abnormal_sleep_pattern0.83230911
105MP0008057_abnormal_DNA_replication0.82616336
106MP0004510_myositis0.82164884
107MP0001730_embryonic_growth_arrest0.81650056
108MP0002009_preneoplasia0.80881002
109MP0005666_abnormal_adipose_tissue0.80758147
110MP0009697_abnormal_copulation0.80673121
111MP0002127_abnormal_cardiovascular_syste0.78903200
112MP0003122_maternal_imprinting0.77268838
113MP0003705_abnormal_hypodermis_morpholog0.76757010
114MP0002882_abnormal_neuron_morphology0.76408485
115MP0004185_abnormal_adipocyte_glucose0.76097691
116MP0002152_abnormal_brain_morphology0.75584546
117MP0002229_neurodegeneration0.74281805
118MP0001502_abnormal_circadian_rhythm0.73422401
119MP0000358_abnormal_cell_content/0.72705070
120MP0003861_abnormal_nervous_system0.70912300
121MP0000537_abnormal_urethra_morphology0.70594908
122MP0000579_abnormal_nail_morphology0.70391580
123MP0000013_abnormal_adipose_tissue0.69959983
124MP0003631_nervous_system_phenotype0.69207074
125MP0002332_abnormal_exercise_endurance0.69140547
126MP0001905_abnormal_dopamine_level0.68271278
127MP0002557_abnormal_social/conspecific_i0.67954115
128MP0001177_atelectasis0.67321270
129MP0001697_abnormal_embryo_size0.67179182
130MP0004885_abnormal_endolymph0.66527099
131MP0003690_abnormal_glial_cell0.65274842
132MP0005535_abnormal_body_temperature0.65000017
133MP0005646_abnormal_pituitary_gland0.64898059
134MP0002184_abnormal_innervation0.64582673

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.59505617
2Nemaline bodies (HP:0003798)5.37146744
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.31909096
4Type 1 muscle fiber predominance (HP:0003803)4.29276192
5Sudden death (HP:0001699)4.10385688
6Abnormality of alanine metabolism (HP:0010916)4.04216156
7Hyperalaninemia (HP:0003348)4.04216156
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.04216156
9Myokymia (HP:0002411)3.98863990
10Exercise-induced myalgia (HP:0003738)3.87530455
11Ventricular fibrillation (HP:0001663)3.87404916
12Focal motor seizures (HP:0011153)3.81659377
13Calf muscle hypertrophy (HP:0008981)3.64135930
14Myoglobinuria (HP:0002913)3.62586840
15Hepatocellular necrosis (HP:0001404)3.58659506
16Muscle hypertrophy of the lower extremities (HP:0008968)3.53439189
17Hepatic necrosis (HP:0002605)3.47205826
18Myopathic facies (HP:0002058)3.35673597
19Exercise-induced muscle cramps (HP:0003710)3.32235718
20Increased intramyocellular lipid droplets (HP:0012240)3.29616456
21Abnormal mitochondria in muscle tissue (HP:0008316)3.27010033
22Increased CSF lactate (HP:0002490)3.23444099
23Mitochondrial inheritance (HP:0001427)3.14184014
24Centrally nucleated skeletal muscle fibers (HP:0003687)3.11877583
25Acute necrotizing encephalopathy (HP:0006965)3.07328054
26Increased muscle lipid content (HP:0009058)3.06775112
27Bundle branch block (HP:0011710)3.00480075
28Calcaneovalgus deformity (HP:0001848)2.90799017
29Atrial fibrillation (HP:0005110)2.90721039
30Visual hallucinations (HP:0002367)2.89215630
31Abnormality of skeletal muscle fiber size (HP:0012084)2.87489825
32Increased hepatocellular lipid droplets (HP:0006565)2.83440298
33Primary atrial arrhythmia (HP:0001692)2.82278555
34Syncope (HP:0001279)2.81811207
35Supraventricular tachycardia (HP:0004755)2.81587835
36Distal arthrogryposis (HP:0005684)2.80750907
37Lipid accumulation in hepatocytes (HP:0006561)2.78621772
38Ragged-red muscle fibers (HP:0003200)2.78412503
39Cerebral edema (HP:0002181)2.77764623
40Increased variability in muscle fiber diameter (HP:0003557)2.77640591
41Focal seizures (HP:0007359)2.74396658
42Lactic acidosis (HP:0003128)2.73140725
43Increased serum pyruvate (HP:0003542)2.72616330
44Abnormality of glycolysis (HP:0004366)2.72616330
45Abnormal atrioventricular conduction (HP:0005150)2.71925294
46Acute encephalopathy (HP:0006846)2.71663627
47Pheochromocytoma (HP:0002666)2.70327678
48Supraventricular arrhythmia (HP:0005115)2.70192660
49EMG: neuropathic changes (HP:0003445)2.70033697
50Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.68950911
51Increased serum lactate (HP:0002151)2.68347020
52Neuroendocrine neoplasm (HP:0100634)2.67313678
53Rhabdomyolysis (HP:0003201)2.65490545
54Abnormality of the lower motor neuron (HP:0002366)2.62840339
55Abnormal EKG (HP:0003115)2.61413572
56Progressive macrocephaly (HP:0004481)2.60823611
57Prolonged QT interval (HP:0001657)2.60388430
58Neck muscle weakness (HP:0000467)2.55498799
59Abnormality of the calf musculature (HP:0001430)2.55382535
60Asymmetric septal hypertrophy (HP:0001670)2.54322637
61Ventricular arrhythmia (HP:0004308)2.52765803
62Emotional lability (HP:0000712)2.50715575
63Exercise intolerance (HP:0003546)2.49333000
64Urinary urgency (HP:0000012)2.47418688
65Palpitations (HP:0001962)2.46711454
66Lipoatrophy (HP:0100578)2.45765738
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44713814
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44713814
69Deformed tarsal bones (HP:0008119)2.44594419
70Impaired vibration sensation in the lower limbs (HP:0002166)2.43921060
71Poor eye contact (HP:0000817)2.43229256
72Progressive muscle weakness (HP:0003323)2.40044325
73Myotonia (HP:0002486)2.34874607
74Subaortic stenosis (HP:0001682)2.33094509
75Abnormality of the left ventricular outflow tract (HP:0011103)2.33094509
76EMG: myopathic abnormalities (HP:0003458)2.30468095
77Abnormality of the foot musculature (HP:0001436)2.28031839
78Ventricular tachycardia (HP:0004756)2.23784792
79Muscle stiffness (HP:0003552)2.22731683
80CNS demyelination (HP:0007305)2.22102392
81Heart block (HP:0012722)2.18146335
82Respiratory failure (HP:0002878)2.17538326
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17342982
84Broad-based gait (HP:0002136)2.16947189
85Neoplasm of the peripheral nervous system (HP:0100007)2.16622627
86Tetraplegia (HP:0002445)2.16383023
87Abnormal social behavior (HP:0012433)2.15140951
88Impaired social interactions (HP:0000735)2.15140951
89Muscle fiber splitting (HP:0003555)2.13435560
90Dysdiadochokinesis (HP:0002075)2.13050114
91Rimmed vacuoles (HP:0003805)2.11863813
92Foot dorsiflexor weakness (HP:0009027)2.11437849
93Distal lower limb muscle weakness (HP:0009053)2.10720031
94Atrioventricular block (HP:0001678)2.10342743
95Anxiety (HP:0000739)2.09155516
96Difficulty climbing stairs (HP:0003551)2.07498120
97Areflexia of lower limbs (HP:0002522)2.06575472
98Difficulty running (HP:0009046)2.06451974
99Round ear (HP:0100830)2.04843070
100Increased connective tissue (HP:0009025)2.04321121
101Absence seizures (HP:0002121)2.04310549
102Gout (HP:0001997)2.02617602
103Dysmetric saccades (HP:0000641)2.02565855
104Postural instability (HP:0002172)2.02502266
105Impaired smooth pursuit (HP:0007772)2.01682760
106Shoulder girdle muscle weakness (HP:0003547)2.01585016
107Hypoglycemic coma (HP:0001325)2.00095838
108Frequent falls (HP:0002359)1.99926297
109Annular pancreas (HP:0001734)1.99092655
110Dilated cardiomyopathy (HP:0001644)1.98942844
111Cerebral hypomyelination (HP:0006808)1.98758773
112Atonic seizures (HP:0010819)1.97516813
113Generalized tonic-clonic seizures (HP:0002069)1.97132742
114Delayed CNS myelination (HP:0002188)1.96843232
115Dialeptic seizures (HP:0011146)1.96492652
116Absent phalangeal crease (HP:0006109)1.94722591
117Depression (HP:0000716)1.93116718
118Unsteady gait (HP:0002317)1.93013013
119Athetosis (HP:0002305)1.92986983
120Gliosis (HP:0002171)1.92164470
121Ankle clonus (HP:0011448)1.91168585
122Hyporeflexia of lower limbs (HP:0002600)1.91166202
123Hyperammonemia (HP:0001987)1.90990619
124Abnormality of the vocal cords (HP:0008777)1.90523875
125Peripheral hypomyelination (HP:0007182)1.88193617
126Abnormality of the calcaneus (HP:0008364)1.87837160
127Hyperinsulinemic hypoglycemia (HP:0000825)1.70811892
128Progressive external ophthalmoplegia (HP:0000590)1.70635547
129Hypoplastic left heart (HP:0004383)1.69991006
130Resting tremor (HP:0002322)1.66088940
131Generalized muscle weakness (HP:0003324)1.65216317
132Action tremor (HP:0002345)1.64566913
133Congenital malformation of the right heart (HP:0011723)1.60000989
134Double outlet right ventricle (HP:0001719)1.60000989
135Mildly elevated creatine phosphokinase (HP:0008180)1.59858959
136Turricephaly (HP:0000262)1.58332076
137Partial duplication of thumb phalanx (HP:0009944)1.55470765
138Back pain (HP:0003418)1.54304649
139Bulbar palsy (HP:0001283)1.53678537
140Abnormal finger flexion creases (HP:0006143)1.53674960
141Scapular winging (HP:0003691)1.52000248
142Hyperglycinuria (HP:0003108)1.51688292
143Abnormality of the salivary glands (HP:0010286)1.48853574
144Insomnia (HP:0100785)1.48664457
145Transposition of the great arteries (HP:0001669)1.48444110
146Abnormal connection of the cardiac segments (HP:0011545)1.48444110
147Abnormal ventriculo-arterial connection (HP:0011563)1.48444110
148Fetal akinesia sequence (HP:0001989)1.47944537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.77367155
2PNCK4.35435628
3NEK13.43666988
4NTRK33.33395002
5EPHA43.26644325
6MAP3K93.18973609
7EEF2K2.62493286
8PDK32.51256100
9PDK42.51256100
10LMTK22.22991435
11SCYL22.10683765
12TRIB32.08748208
13PINK11.99562326
14MAP3K41.99118244
15MAP3K121.97836311
16CAMK1G1.96354728
17BUB11.96140197
18KSR21.87339074
19PKN21.86032294
20OBSCN1.81123063
21CDK191.76951742
22MINK11.76752928
23PHKG21.75219939
24PHKG11.75219939
25TNIK1.74712353
26BCKDK1.70898674
27KSR11.55551227
28TLK11.52088840
29MAP2K41.50966106
30ICK1.42347301
31CAMKK11.27331233
32ARAF1.26570737
33NME11.25413659
34MAPK121.22918264
35STK381.22746431
36UHMK11.21783133
37PDK21.19108998
38MAP2K71.15517259
39TTN1.10269695
40CAMKK21.08587694
41SMG11.07132154
42DAPK11.06477541
43SRPK11.01227120
44CAMK1D0.99673933
45EIF2AK10.96365369
46BRSK10.93662413
47STK160.92649869
48MAP3K100.92360339
49PLK40.91642336
50AKT20.91135378
51BRSK20.88193291
52CASK0.87868658
53FLT30.84286731
54MAP3K130.83890485
55FGFR20.83185927
56CAMK10.82671832
57PAK60.81772483
58MAPKAPK50.80841882
59TYRO30.80671865
60DAPK20.80474287
61CAMK2B0.80170025
62RIPK10.78462432
63PDK10.76113997
64PRKD30.75773897
65ALK0.75516111
66TTK0.73724234
67BRAF0.73425130
68RAF10.72063173
69TESK20.71796688
70DAPK30.70054964
71PRKAA10.68409147
72MYLK0.67158755
73SGK30.66292268
74NEK90.65437005
75MAPK100.65020739
76MAPKAPK30.64583003
77PLK10.64524211
78PLK20.64285982
79CDK50.64198251
80EIF2AK30.63949105
81SGK2230.63482866
82SGK4940.63482866
83CDK140.63476361
84WNK10.63095279
85MAP2K60.62396996
86CDK180.62347048
87PDPK10.58736878
88NTRK10.58696291
89CDK150.58264536
90PRKCG0.57993926
91DMPK0.57973601
92CCNB10.56693822
93CAMK2D0.55769247
94OXSR10.55382528
95MAP3K110.54411778
96SGK20.53776382
97PRPF4B0.53025610
98LIMK10.52880814
99CDK120.51269354
100CDK11A0.51129007
101PDGFRA0.49988060
102CDC70.49130487
103RPS6KA30.48904145
104BCR0.47444441
105RPS6KB10.47421930
106NEK20.47199599
107CAMK2G0.46799490
108RET0.46187602
109SGK10.46076325
110MAP3K60.46017777
111TAOK10.45800500
112MAP3K70.45360638
113STK390.45011580
114WNK40.44396026
115PTK2B0.44303433
116STK110.44289189
117MTOR0.43522200
118TSSK60.43334956
119PKN10.42540096
120CSNK1E0.41356316
121PRKAA20.41263197
122CAMK2A0.40773282
123MAP3K20.39955610
124AURKA0.39923688
125PRKDC0.37502079
126DYRK1B0.36587282
127CDK10.35875797
128GRK50.35591174
129FES0.34743954
130DYRK1A0.34659980
131WNK30.34046136
132MAP3K50.33433107
133MAP2K10.33386563
134MAPK130.32332055
135PAK30.31901709
136LATS20.31629324
137NTRK20.31090309
138MARK10.28785976
139CAMK40.28501133
140MUSK0.28426439
141MAP3K80.28290539
142PLK30.28169656

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.09106699
2Nitrogen metabolism_Homo sapiens_hsa009103.35915945
3Cardiac muscle contraction_Homo sapiens_hsa042602.99812054
4Parkinsons disease_Homo sapiens_hsa050122.97093462
5Oxidative phosphorylation_Homo sapiens_hsa001902.74320608
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.73068890
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19660424
8Synaptic vesicle cycle_Homo sapiens_hsa047212.12959210
9Carbon metabolism_Homo sapiens_hsa012002.07352195
10Alzheimers disease_Homo sapiens_hsa050101.99600967
11Huntingtons disease_Homo sapiens_hsa050161.96691637
12Arginine and proline metabolism_Homo sapiens_hsa003301.87289368
13Propanoate metabolism_Homo sapiens_hsa006401.87160092
14Mismatch repair_Homo sapiens_hsa034301.85580962
15Long-term potentiation_Homo sapiens_hsa047201.84400827
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77766793
17Nicotine addiction_Homo sapiens_hsa050331.72955541
18Oocyte meiosis_Homo sapiens_hsa041141.70330403
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64097870
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52621434
21Vitamin B6 metabolism_Homo sapiens_hsa007501.50575239
22Amphetamine addiction_Homo sapiens_hsa050311.49276292
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48876821
24DNA replication_Homo sapiens_hsa030301.48860592
25Phenylalanine metabolism_Homo sapiens_hsa003601.48249493
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45785297
27Circadian entrainment_Homo sapiens_hsa047131.43328146
28Olfactory transduction_Homo sapiens_hsa047401.39446806
29Biosynthesis of amino acids_Homo sapiens_hsa012301.37601890
30Pyruvate metabolism_Homo sapiens_hsa006201.35830013
31GABAergic synapse_Homo sapiens_hsa047271.34550114
32Dopaminergic synapse_Homo sapiens_hsa047281.34479519
33Proteasome_Homo sapiens_hsa030501.34430725
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32895337
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31569910
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30797601
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.26083699
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25030540
39Glutamatergic synapse_Homo sapiens_hsa047241.24869711
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20939771
41Sulfur relay system_Homo sapiens_hsa041221.19543327
42Dilated cardiomyopathy_Homo sapiens_hsa054141.17862985
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16676474
44Oxytocin signaling pathway_Homo sapiens_hsa049211.15348226
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13703882
46Morphine addiction_Homo sapiens_hsa050321.13578923
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13372504
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11351456
49Calcium signaling pathway_Homo sapiens_hsa040201.09082361
50Gastric acid secretion_Homo sapiens_hsa049711.08918740
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08512172
52Insulin secretion_Homo sapiens_hsa049111.05663927
53AMPK signaling pathway_Homo sapiens_hsa041521.05068408
54RNA transport_Homo sapiens_hsa030131.02097311
55Ribosome_Homo sapiens_hsa030101.00996730
56Fatty acid elongation_Homo sapiens_hsa000621.00902733
57Fructose and mannose metabolism_Homo sapiens_hsa000510.95061042
58Circadian rhythm_Homo sapiens_hsa047100.94326348
59Cholinergic synapse_Homo sapiens_hsa047250.92067082
60Fatty acid degradation_Homo sapiens_hsa000710.91645407
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91502575
62RNA polymerase_Homo sapiens_hsa030200.91198248
63Arginine biosynthesis_Homo sapiens_hsa002200.89257298
64Salivary secretion_Homo sapiens_hsa049700.89247466
65Fatty acid biosynthesis_Homo sapiens_hsa000610.88630408
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88013053
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86372193
68Prion diseases_Homo sapiens_hsa050200.85280551
69beta-Alanine metabolism_Homo sapiens_hsa004100.85140998
70Glucagon signaling pathway_Homo sapiens_hsa049220.84807629
71Bile secretion_Homo sapiens_hsa049760.82394544
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.79453154
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78499830
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73857958
75GnRH signaling pathway_Homo sapiens_hsa049120.73641502
76Taste transduction_Homo sapiens_hsa047420.70851023
77Lysine degradation_Homo sapiens_hsa003100.69972096
78PPAR signaling pathway_Homo sapiens_hsa033200.68973234
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68609649
80Gap junction_Homo sapiens_hsa045400.68259645
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68188735
82Fatty acid metabolism_Homo sapiens_hsa012120.68084641
83Nucleotide excision repair_Homo sapiens_hsa034200.67821503
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66664741
85Pentose phosphate pathway_Homo sapiens_hsa000300.66657930
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66647965
87Renin secretion_Homo sapiens_hsa049240.66438253
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64747285
89mRNA surveillance pathway_Homo sapiens_hsa030150.64664282
90Melanogenesis_Homo sapiens_hsa049160.64063275
91Butanoate metabolism_Homo sapiens_hsa006500.63120744
92Type II diabetes mellitus_Homo sapiens_hsa049300.61227935
93Pyrimidine metabolism_Homo sapiens_hsa002400.60666908
94Histidine metabolism_Homo sapiens_hsa003400.60145452
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60117920
96Purine metabolism_Homo sapiens_hsa002300.59809854
97Collecting duct acid secretion_Homo sapiens_hsa049660.59201135
98Insulin signaling pathway_Homo sapiens_hsa049100.58765831
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58378283
100Long-term depression_Homo sapiens_hsa047300.58150494
101Galactose metabolism_Homo sapiens_hsa000520.57435919
102cAMP signaling pathway_Homo sapiens_hsa040240.57038199
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.56161180
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55007449
105Cocaine addiction_Homo sapiens_hsa050300.54795729
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54579230
107Tyrosine metabolism_Homo sapiens_hsa003500.54071426
108Folate biosynthesis_Homo sapiens_hsa007900.53285449
109Spliceosome_Homo sapiens_hsa030400.51936292
110Tight junction_Homo sapiens_hsa045300.48979128
111Thyroid hormone synthesis_Homo sapiens_hsa049180.47001176
112Alcoholism_Homo sapiens_hsa050340.46934723
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.46148556
114Homologous recombination_Homo sapiens_hsa034400.45882528
115Cell cycle_Homo sapiens_hsa041100.45673874
116Estrogen signaling pathway_Homo sapiens_hsa049150.42738219
117Endometrial cancer_Homo sapiens_hsa052130.41942804
118ErbB signaling pathway_Homo sapiens_hsa040120.41480294
119Non-homologous end-joining_Homo sapiens_hsa034500.40551103
120mTOR signaling pathway_Homo sapiens_hsa041500.39606683
121Wnt signaling pathway_Homo sapiens_hsa043100.38972591
122Serotonergic synapse_Homo sapiens_hsa047260.38071929
123Insulin resistance_Homo sapiens_hsa049310.37005012
124RNA degradation_Homo sapiens_hsa030180.36988768
125HIF-1 signaling pathway_Homo sapiens_hsa040660.36918177
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36815567
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36627152
128Thyroid cancer_Homo sapiens_hsa052160.36356530
129Glioma_Homo sapiens_hsa052140.35536815
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.35488217
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34022087
132Vibrio cholerae infection_Homo sapiens_hsa051100.33043044
133Pancreatic secretion_Homo sapiens_hsa049720.31636935
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28379794

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