ATPAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 alpha subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. This gene is located within the Smith-Magenis syndrome region on chromosome 17. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branched-chain amino acid catabolic process (GO:0009083)5.41730374
2DNA deamination (GO:0045006)4.94450076
3ribosomal small subunit assembly (GO:0000028)4.84720474
4branched-chain amino acid metabolic process (GO:0009081)4.47818976
5DNA strand elongation involved in DNA replication (GO:0006271)4.34926448
6telomere maintenance via semi-conservative replication (GO:0032201)4.33068422
7purine nucleobase biosynthetic process (GO:0009113)4.28011969
8DNA strand elongation (GO:0022616)4.26530787
9nucleobase biosynthetic process (GO:0046112)4.19259707
10proteasome assembly (GO:0043248)4.16687773
11amino acid salvage (GO:0043102)4.16633784
12L-methionine salvage (GO:0071267)4.16633784
13L-methionine biosynthetic process (GO:0071265)4.16633784
14protein complex biogenesis (GO:0070271)4.13297744
15valine metabolic process (GO:0006573)4.13260252
16metallo-sulfur cluster assembly (GO:0031163)4.12746413
17iron-sulfur cluster assembly (GO:0016226)4.12746413
18DNA replication initiation (GO:0006270)4.07774827
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.93438157
20NADH dehydrogenase complex assembly (GO:0010257)3.93438157
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93438157
22ubiquinone biosynthetic process (GO:0006744)3.92494041
23respiratory chain complex IV assembly (GO:0008535)3.88716801
24mannosylation (GO:0097502)3.86692816
25telomere maintenance via recombination (GO:0000722)3.84837181
26mitochondrial respiratory chain complex assembly (GO:0033108)3.82260907
27cytochrome complex assembly (GO:0017004)3.81620849
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81552713
29DNA replication checkpoint (GO:0000076)3.76435383
30formation of translation preinitiation complex (GO:0001731)3.69901497
31ubiquinone metabolic process (GO:0006743)3.66298217
32ribosome biogenesis (GO:0042254)3.63713831
33protein-cofactor linkage (GO:0018065)3.63521252
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58584710
35ribosome assembly (GO:0042255)3.57076436
36IMP biosynthetic process (GO:0006188)3.54269605
37rRNA modification (GO:0000154)3.49175853
38mitotic recombination (GO:0006312)3.48789831
39preassembly of GPI anchor in ER membrane (GO:0016254)3.47175543
40maturation of SSU-rRNA (GO:0030490)3.45996651
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.44818222
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44117020
43water-soluble vitamin biosynthetic process (GO:0042364)3.40908323
44response to pheromone (GO:0019236)3.40298184
45viral mRNA export from host cell nucleus (GO:0046784)3.38838941
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36741253
47ribonucleoprotein complex biogenesis (GO:0022613)3.34703877
48telomere maintenance via telomere lengthening (GO:0010833)3.33512512
49pseudouridine synthesis (GO:0001522)3.30113249
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29645369
51cullin deneddylation (GO:0010388)3.26481793
52CENP-A containing nucleosome assembly (GO:0034080)3.25977440
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24111337
54negative regulation of ligase activity (GO:0051352)3.24111337
55spliceosomal snRNP assembly (GO:0000387)3.23555261
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20393303
57ribosomal large subunit biogenesis (GO:0042273)3.19568809
58folic acid metabolic process (GO:0046655)3.18687170
59protein deneddylation (GO:0000338)3.16425353
60mitotic metaphase plate congression (GO:0007080)3.13774535
61chromatin remodeling at centromere (GO:0031055)3.12646389
62methionine biosynthetic process (GO:0009086)3.12074210
63quinone biosynthetic process (GO:1901663)3.11907479
64termination of RNA polymerase III transcription (GO:0006386)3.10839555
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.10839555
66oxidative phosphorylation (GO:0006119)3.10276451
67transcription-coupled nucleotide-excision repair (GO:0006283)3.09848717
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.09255190
69IMP metabolic process (GO:0046040)3.08981930
70ATP synthesis coupled proton transport (GO:0015986)3.08814151
71energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08814151
72inositol phosphate catabolic process (GO:0071545)3.08560896
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.07455678
74regulation of cellular amino acid metabolic process (GO:0006521)3.06950776
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05998256
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02776021
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02776021
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02776021
79GPI anchor metabolic process (GO:0006505)3.02706921
80rRNA processing (GO:0006364)3.01606997
81viral transcription (GO:0019083)3.01154818
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01030285
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01030285
84GPI anchor biosynthetic process (GO:0006506)3.00918190
85translational termination (GO:0006415)2.99486618
86GMP metabolic process (GO:0046037)2.98734813
87translational elongation (GO:0006414)2.98315812
88folic acid-containing compound biosynthetic process (GO:0009396)2.97824630
89DNA unwinding involved in DNA replication (GO:0006268)2.96016389
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94726733
91ribosomal small subunit biogenesis (GO:0042274)2.94585519
92regulation of mitochondrial translation (GO:0070129)2.94323460
93NADH metabolic process (GO:0006734)2.94254102
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.93310742
95signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93310742
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93120108
97DNA replication-independent nucleosome assembly (GO:0006336)2.92798726
98DNA replication-independent nucleosome organization (GO:0034724)2.92798726
99cellular component biogenesis (GO:0044085)2.92632609
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.92285657
101G1/S transition of mitotic cell cycle (GO:0000082)2.91798305
102cell cycle G1/S phase transition (GO:0044843)2.91798305
103signal transduction involved in cell cycle checkpoint (GO:0072395)2.90823887
104rRNA methylation (GO:0031167)2.90795631
105rRNA metabolic process (GO:0016072)2.90635035
106translation (GO:0006412)2.89730706
107deoxyribonucleotide biosynthetic process (GO:0009263)2.89633065
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89249319
1097-methylguanosine mRNA capping (GO:0006370)2.86288143
110purine deoxyribonucleotide catabolic process (GO:0009155)2.85231633
111L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85030787
112methionine metabolic process (GO:0006555)2.84209660
113pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83782593
114positive regulation of ligase activity (GO:0051351)2.83142387
115autophagic vacuole fusion (GO:0000046)2.83117484
116protein targeting to mitochondrion (GO:0006626)2.82846830
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82424382
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82424382
119C-terminal protein lipidation (GO:0006501)2.82163038
120pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.81702021
121deoxyribonucleotide catabolic process (GO:0009264)2.80985625
122translational initiation (GO:0006413)2.80657666
1237-methylguanosine RNA capping (GO:0009452)2.80139168
124RNA capping (GO:0036260)2.80139168
125ATP hydrolysis coupled proton transport (GO:0015991)2.79942057
126energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.79942057
127SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79601550
128metaphase plate congression (GO:0051310)2.79414150
129C-terminal protein amino acid modification (GO:0018410)2.79209790
130mitochondrial RNA metabolic process (GO:0000959)2.79122869
131DNA integration (GO:0015074)2.78688559
132mitotic nuclear envelope disassembly (GO:0007077)2.77237503
133pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.76076819
134tricarboxylic acid cycle (GO:0006099)2.76062850
135cellular ketone body metabolic process (GO:0046950)2.74634006
136positive regulation of mitochondrial fission (GO:0090141)2.74468980
137termination of RNA polymerase I transcription (GO:0006363)2.74008308
138regulation of double-strand break repair via homologous recombination (GO:0010569)2.73198628
139mitochondrial DNA replication (GO:0006264)2.73132099
140telomere organization (GO:0032200)2.73087381
141adenosine metabolic process (GO:0046085)2.72126178
142telomere maintenance (GO:0000723)2.71980292
143transcription from RNA polymerase I promoter (GO:0006360)2.71775097
144antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.71140185
145postreplication repair (GO:0006301)2.70731039
146establishment of protein localization to mitochondrion (GO:0072655)2.70683762
147peptidyl-histidine modification (GO:0018202)2.70504489
148respiratory electron transport chain (GO:0022904)2.70279603
149DNA-dependent DNA replication (GO:0006261)2.70190751
150maturation of 5.8S rRNA (GO:0000460)2.70144256
151tRNA methylation (GO:0030488)2.70024836
152purine-containing compound salvage (GO:0043101)2.69728056
153electron transport chain (GO:0022900)2.69628427
154inositol phosphate dephosphorylation (GO:0046855)2.68141435
155phosphorylated carbohydrate dephosphorylation (GO:0046838)2.68141435
156regulation of cilium movement (GO:0003352)2.66609585
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66232948
158GTP biosynthetic process (GO:0006183)2.66144505
159polyol catabolic process (GO:0046174)2.63328499
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62058328
161axoneme assembly (GO:0035082)2.61952753
162ketone body metabolic process (GO:1902224)2.61239229
163protein localization to mitochondrion (GO:0070585)2.60123185
164fucose catabolic process (GO:0019317)2.59289348
165L-fucose metabolic process (GO:0042354)2.59289348
166L-fucose catabolic process (GO:0042355)2.59289348
167deoxyribose phosphate catabolic process (GO:0046386)2.58159267
168platelet dense granule organization (GO:0060155)2.58020654
169DNA demethylation (GO:0080111)2.56729166
170RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55841280
171cellular metabolic compound salvage (GO:0043094)2.54640035
172aspartate family amino acid biosynthetic process (GO:0009067)2.53919158
173purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.53733531
174tRNA processing (GO:0008033)2.52354340
175organelle membrane fusion (GO:0090174)2.52111492
176histone H2A acetylation (GO:0043968)2.51673038
177somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48339229
178somatic hypermutation of immunoglobulin genes (GO:0016446)2.48339229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52892005
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05386890
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96006321
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84169506
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49212080
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.43710403
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.34746370
8ZNF274_21170338_ChIP-Seq_K562_Hela3.33915004
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.07461651
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93169311
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86988789
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86318417
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74860988
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69953647
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67437157
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58698655
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53612891
18VDR_23849224_ChIP-Seq_CD4+_Human2.48062812
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38025851
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25718857
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21752898
22XRN2_22483619_ChIP-Seq_HELA_Human2.17605873
23* FOXP3_21729870_ChIP-Seq_TREG_Human2.16570278
24DCP1A_22483619_ChIP-Seq_HELA_Human2.16102514
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15878773
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14836252
27GABP_19822575_ChIP-Seq_HepG2_Human2.12928557
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.12776332
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.12336533
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09969563
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09139602
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08991126
33* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06703850
34VDR_22108803_ChIP-Seq_LS180_Human1.98619782
35* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96522960
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90355402
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.88411148
38IGF1R_20145208_ChIP-Seq_DFB_Human1.79145155
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79135849
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76417736
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75888633
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75091624
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69991919
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68226272
45ELK1_19687146_ChIP-ChIP_HELA_Human1.67781764
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66806117
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66626337
48TTF2_22483619_ChIP-Seq_HELA_Human1.65853035
49* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64917007
50AR_21909140_ChIP-Seq_LNCAP_Human1.62829975
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61207157
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60521639
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60256947
54CIITA_25753668_ChIP-Seq_RAJI_Human1.59333069
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59222763
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.57599944
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57417407
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55625148
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54945409
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50648836
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48232532
62TP53_22573176_ChIP-Seq_HFKS_Human1.41830343
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41829717
64* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41134182
65EWS_26573619_Chip-Seq_HEK293_Human1.40837396
66IRF1_19129219_ChIP-ChIP_H3396_Human1.35632280
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.34096680
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33571009
69AR_20517297_ChIP-Seq_VCAP_Human1.33430504
70KDM5A_27292631_Chip-Seq_BREAST_Human1.33340851
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29492301
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29144940
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28333205
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28096693
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28042864
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27251453
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24730824
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21180992
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20377013
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19945751
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14004822
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13782737
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11925376
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11354094
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11321480
86SPI1_23547873_ChIP-Seq_NB4_Human1.09959637
87MYC_22102868_ChIP-Seq_BL_Human1.09327737
88TFEB_21752829_ChIP-Seq_HELA_Human1.06460476
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05652176
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05437936
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04625862
92NANOG_20526341_ChIP-Seq_ESCs_Human1.04042756
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03297929
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.03297929
95NCOR_22424771_ChIP-Seq_293T_Human1.03225958
96SOX2_19829295_ChIP-Seq_ESCs_Human1.02892610
97NANOG_19829295_ChIP-Seq_ESCs_Human1.02892610
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02700018
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00493810
100FUS_26573619_Chip-Seq_HEK293_Human0.99740303
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99449929
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99141959
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99103307
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97955151
105ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97935787
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.97751729
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95992721
108* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95208137
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.95178738
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94745212
111GATA3_21878914_ChIP-Seq_MCF-7_Human0.94281593
112ERA_21632823_ChIP-Seq_H3396_Human0.93756864
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93454122
114FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93113425
115BCL6_27268052_Chip-Seq_Bcells_Human0.92643618
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92027731
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91802567
118* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91406255
119* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89611626
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88278422
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87725602
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87206649
123CBP_20019798_ChIP-Seq_JUKART_Human0.87176809
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87176809
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86964189
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86766882
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86697037
128TAF2_19829295_ChIP-Seq_ESCs_Human0.85881590
129MYC_19829295_ChIP-Seq_ESCs_Human0.85843653
130MYC_18940864_ChIP-ChIP_HL60_Human0.85301492
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84967167
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84652810
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84251526
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83836985
135GATA3_26560356_Chip-Seq_TH2_Human0.83760405
136FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82537554
137* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79098879
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.77416060
139* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77313271
140IRF8_22096565_ChIP-ChIP_GC-B_Human0.77157079
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75477074
142SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73405852
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70557449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.87954503
2MP0010094_abnormal_chromosome_stability3.74688189
3MP0003111_abnormal_nucleus_morphology3.41681659
4MP0004957_abnormal_blastocyst_morpholog3.40048090
5MP0003077_abnormal_cell_cycle3.18283239
6MP0008058_abnormal_DNA_repair3.06594933
7MP0002396_abnormal_hematopoietic_system2.90565666
8MP0002102_abnormal_ear_morphology2.83777393
9MP0003806_abnormal_nucleotide_metabolis2.77409456
10MP0008007_abnormal_cellular_replicative2.68999864
11MP0008057_abnormal_DNA_replication2.67295892
12MP0000372_irregular_coat_pigmentation2.64118632
13MP0004147_increased_porphyrin_level2.56323958
14MP0006036_abnormal_mitochondrial_physio2.39869915
15MP0005670_abnormal_white_adipose2.35381090
16MP0008875_abnormal_xenobiotic_pharmacok2.26039761
17MP0002138_abnormal_hepatobiliary_system2.20700252
18MP0002837_dystrophic_cardiac_calcinosis2.15156560
19MP0003186_abnormal_redox_activity2.05589932
20MP0002876_abnormal_thyroid_physiology2.03123232
21MP0002163_abnormal_gland_morphology2.01263199
22MP0001529_abnormal_vocalization2.00852139
23MP0005075_abnormal_melanosome_morpholog2.00513499
24MP0008932_abnormal_embryonic_tissue1.98804318
25MP0005410_abnormal_fertilization1.94798553
26MP0005551_abnormal_eye_electrophysiolog1.88997824
27MP0003786_premature_aging1.86615752
28MP0002132_abnormal_respiratory_system1.84758180
29MP0006072_abnormal_retinal_apoptosis1.74321074
30MP0001984_abnormal_olfaction1.65681842
31MP0001764_abnormal_homeostasis1.64736246
32MP0003646_muscle_fatigue1.61361051
33MP0005397_hematopoietic_system_phenotyp1.60967554
34MP0001545_abnormal_hematopoietic_system1.60967554
35MP0001986_abnormal_taste_sensitivity1.60436802
36MP0005645_abnormal_hypothalamus_physiol1.56574029
37MP0005379_endocrine/exocrine_gland_phen1.56085034
38MP0009046_muscle_twitch1.55802496
39MP0006035_abnormal_mitochondrial_morpho1.55759601
40MP0008789_abnormal_olfactory_epithelium1.55532040
41MP0003656_abnormal_erythrocyte_physiolo1.54100315
42MP0003123_paternal_imprinting1.53544721
43MP0003011_delayed_dark_adaptation1.53091541
44MP0009333_abnormal_splenocyte_physiolog1.52907618
45MP0005084_abnormal_gallbladder_morpholo1.52236409
46MP0001730_embryonic_growth_arrest1.50384578
47MP0003195_calcinosis1.49469901
48MP0005646_abnormal_pituitary_gland1.47706793
49MP0009697_abnormal_copulation1.47130274
50MP0001968_abnormal_touch/_nociception1.46153839
51MP0003787_abnormal_imprinting1.45611635
52MP0000490_abnormal_crypts_of1.45022113
53MP0003221_abnormal_cardiomyocyte_apopto1.44605297
54MP0008872_abnormal_physiological_respon1.43853223
55MP0001835_abnormal_antigen_presentation1.43481832
56MP0005253_abnormal_eye_physiology1.42088703
57MP0003718_maternal_effect1.41769857
58MP0004133_heterotaxia1.39553548
59MP0000350_abnormal_cell_proliferation1.38334511
60MP0003763_abnormal_thymus_physiology1.37326428
61MP0006292_abnormal_olfactory_placode1.34603692
62MP0003880_abnormal_central_pattern1.34555240
63MP0004808_abnormal_hematopoietic_stem1.34330818
64MP0000358_abnormal_cell_content/1.33291650
65MP0002398_abnormal_bone_marrow1.31504354
66MP0000689_abnormal_spleen_morphology1.28936071
67MP0002653_abnormal_ependyma_morphology1.28893532
68MP0002019_abnormal_tumor_incidence1.28412712
69MP0001853_heart_inflammation1.28334871
70MP0005394_taste/olfaction_phenotype1.26760302
71MP0005499_abnormal_olfactory_system1.26760302
72MP0002722_abnormal_immune_system1.25780647
73MP0006276_abnormal_autonomic_nervous1.25610023
74MP0008877_abnormal_DNA_methylation1.24231697
75MP0000313_abnormal_cell_death1.22943083
76MP0002736_abnormal_nociception_after1.22306347
77MP0008995_early_reproductive_senescence1.19609215
78MP0003724_increased_susceptibility_to1.18578293
79MP0003878_abnormal_ear_physiology1.17852231
80MP0005377_hearing/vestibular/ear_phenot1.17852231
81MP0009785_altered_susceptibility_to1.17184298
82MP0002080_prenatal_lethality1.14799215
83MP0006054_spinal_hemorrhage1.13730642
84MP0005380_embryogenesis_phenotype1.12654101
85MP0001672_abnormal_embryogenesis/_devel1.12654101
86MP0010307_abnormal_tumor_latency1.12353235
87MP0005671_abnormal_response_to1.12025262
88MP0009764_decreased_sensitivity_to1.11202799
89MP0002277_abnormal_respiratory_mucosa1.11068858
90MP0002429_abnormal_blood_cell1.09980539
91MP0000015_abnormal_ear_pigmentation1.06752985
92MP0005220_abnormal_exocrine_pancreas1.06697538
93MP0001697_abnormal_embryo_size1.05755760
94MP0002822_catalepsy1.05622159
95MP0003567_abnormal_fetal_cardiomyocyte1.05373713
96MP0003984_embryonic_growth_retardation1.04985073
97MP0000703_abnormal_thymus_morphology1.02387770
98MP0002088_abnormal_embryonic_growth/wei1.01637741
99MP0002095_abnormal_skin_pigmentation1.01197069
100MP0005266_abnormal_metabolism0.99053274
101MP0002928_abnormal_bile_duct0.99020259
102MP0002160_abnormal_reproductive_system0.98718725
103MP0003698_abnormal_male_reproductive0.97778502
104MP0002210_abnormal_sex_determination0.97530993
105MP0002139_abnormal_hepatobiliary_system0.95938544
106MP0002970_abnormal_white_adipose0.95386153
107MP0000858_altered_metastatic_potential0.94971211
108MP0004084_abnormal_cardiac_muscle0.94722245
109MP0000716_abnormal_immune_system0.94082854
110MP0000647_abnormal_sebaceous_gland0.93030013
111MP0001905_abnormal_dopamine_level0.92587879
112MP0008260_abnormal_autophagy0.91042995
113MP0005386_behavior/neurological_phenoty0.90779636
114MP0004924_abnormal_behavior0.90779636
115MP0002090_abnormal_vision0.90335380
116MP0005319_abnormal_enzyme/_coenzyme0.89216432
117MP0000685_abnormal_immune_system0.88290120
118MP0005085_abnormal_gallbladder_physiolo0.87396936
119MP0005636_abnormal_mineral_homeostasis0.86741360
120MP0004142_abnormal_muscle_tone0.86168663
121MP0010352_gastrointestinal_tract_polyps0.85950441
122MP0000427_abnormal_hair_cycle0.85406245
123MP0005389_reproductive_system_phenotype0.85300114
124MP0005464_abnormal_platelet_physiology0.85200610
125MP0005666_abnormal_adipose_tissue0.84358793
126MP0000343_altered_response_to0.84013468
127MP0008873_increased_physiological_sensi0.82020543
128MP0002938_white_spotting0.81785121
129MP0001929_abnormal_gametogenesis0.81730770
130MP0002420_abnormal_adaptive_immunity0.81693507
131MP0001800_abnormal_humoral_immune0.81594729
132MP0003315_abnormal_perineum_morphology0.81535646
133MP0003436_decreased_susceptibility_to0.81054795
134MP0000516_abnormal_urinary_system0.80882032
135MP0005367_renal/urinary_system_phenotyp0.80882032
136MP0001145_abnormal_male_reproductive0.80775843
137MP0002229_neurodegeneration0.80696056
138MP0000598_abnormal_liver_morphology0.79957833
139MP0000749_muscle_degeneration0.79531019
140MP0001819_abnormal_immune_cell0.79529825
141MP0009765_abnormal_xenobiotic_induced0.78811682
142MP0005025_abnormal_response_to0.78512026
143MP0010386_abnormal_urinary_bladder0.78001782
144MP0004130_abnormal_muscle_cell0.77955579
145MP0009840_abnormal_foam_cell0.77070072
146MP0000653_abnormal_sex_gland0.75120496
147MP0009745_abnormal_behavioral_response0.74265828
148MP0000613_abnormal_salivary_gland0.73891353
149MP0005330_cardiomyopathy0.73837747
150MP0004043_abnormal_pH_regulation0.73717970
151MP0002166_altered_tumor_susceptibility0.73665564
152MP0000609_abnormal_liver_physiology0.73664939
153MP0002723_abnormal_immune_serum0.71630333
154MP0002148_abnormal_hypersensitivity_rea0.71598437
155MP0002269_muscular_atrophy0.71353021
156MP0008469_abnormal_protein_level0.71187440
157MP0002452_abnormal_antigen_presenting0.70356146
158MP0005332_abnormal_amino_acid0.69836257
159MP0000750_abnormal_muscle_regeneration0.69544899
160MP0002086_abnormal_extraembryonic_tissu0.67149559
161MP0000465_gastrointestinal_hemorrhage0.66980802
162MP0005174_abnormal_tail_pigmentation0.66572304
163MP0001119_abnormal_female_reproductive0.66211518

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.14235422
2Hepatic necrosis (HP:0002605)3.99689327
3Decreased activity of mitochondrial respiratory chain (HP:0008972)3.96463773
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.96463773
5Hepatocellular necrosis (HP:0001404)3.64597355
6Aplastic anemia (HP:0001915)3.62596491
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.54784665
8Abnormal number of erythroid precursors (HP:0012131)3.45194820
9Pancreatic cysts (HP:0001737)3.44373131
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.41828063
11Abnormality of alanine metabolism (HP:0010916)3.41828063
12Hyperalaninemia (HP:0003348)3.41828063
13Abnormality of cells of the erythroid lineage (HP:0012130)3.36812310
14Reticulocytopenia (HP:0001896)3.28641189
15* Increased serum lactate (HP:0002151)3.25564999
16Increased CSF lactate (HP:0002490)3.11545572
17Pancreatic fibrosis (HP:0100732)3.11201129
18Type I transferrin isoform profile (HP:0003642)3.10728100
19Abnormal mitochondria in muscle tissue (HP:0008316)3.07125745
20Acute necrotizing encephalopathy (HP:0006965)3.04967750
21Mitochondrial inheritance (HP:0001427)2.98549201
22* Lactic acidosis (HP:0003128)2.97358368
23Reduced antithrombin III activity (HP:0001976)2.95930474
24Rhabdomyolysis (HP:0003201)2.93544048
25True hermaphroditism (HP:0010459)2.92985592
26Breast hypoplasia (HP:0003187)2.92087919
27Increased muscle lipid content (HP:0009058)2.90586070
28Oral leukoplakia (HP:0002745)2.88659836
29Acute encephalopathy (HP:0006846)2.80858220
30Medial flaring of the eyebrow (HP:0010747)2.79665784
31Molar tooth sign on MRI (HP:0002419)2.79647008
32Abnormality of midbrain morphology (HP:0002418)2.79647008
33Abnormality of the anterior horn cell (HP:0006802)2.76769970
34Degeneration of anterior horn cells (HP:0002398)2.76769970
35Nausea (HP:0002018)2.74768091
36Increased serum pyruvate (HP:0003542)2.73477852
37Abnormality of glycolysis (HP:0004366)2.73477852
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71861931
39Abnormal protein N-linked glycosylation (HP:0012347)2.71861931
40Abnormal protein glycosylation (HP:0012346)2.71861931
41Abnormal glycosylation (HP:0012345)2.71861931
42Type II lissencephaly (HP:0007260)2.69303135
43Multiple enchondromatosis (HP:0005701)2.68972215
44Abolished electroretinogram (ERG) (HP:0000550)2.68428173
45Bile duct proliferation (HP:0001408)2.68165717
46Abnormal biliary tract physiology (HP:0012439)2.68165717
47Ketosis (HP:0001946)2.67953026
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66083010
49Dicarboxylic aciduria (HP:0003215)2.66083010
50Thrombocytosis (HP:0001894)2.65456241
51Abnormality of fatty-acid metabolism (HP:0004359)2.63074807
52Pancytopenia (HP:0001876)2.59737454
53Microretrognathia (HP:0000308)2.59226187
54Lipid accumulation in hepatocytes (HP:0006561)2.58998285
55Hyperglycinuria (HP:0003108)2.55099834
56Exercise intolerance (HP:0003546)2.54625869
57Generalized aminoaciduria (HP:0002909)2.54547777
58Panhypogammaglobulinemia (HP:0003139)2.52494748
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50548399
60Methylmalonic aciduria (HP:0012120)2.49783523
61Increased intramyocellular lipid droplets (HP:0012240)2.49309844
62Type 2 muscle fiber atrophy (HP:0003554)2.49054377
63Ketoacidosis (HP:0001993)2.48424357
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46562253
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45101344
66Colon cancer (HP:0003003)2.41631890
67Abnormality of serum amino acid levels (HP:0003112)2.41564637
68Cerebral hypomyelination (HP:0006808)2.40964832
69Nephronophthisis (HP:0000090)2.39838580
70Retinal dysplasia (HP:0007973)2.35716045
71Muscle fiber atrophy (HP:0100295)2.35694404
72Progressive macrocephaly (HP:0004481)2.35514001
73Macrocytic anemia (HP:0001972)2.32808033
74Congenital stationary night blindness (HP:0007642)2.32017147
75Rough bone trabeculation (HP:0100670)2.30024643
76Increased hepatocellular lipid droplets (HP:0006565)2.29740154
77Progressive microcephaly (HP:0000253)2.29541809
78Proximal tubulopathy (HP:0000114)2.27472143
79Hyperglycinemia (HP:0002154)2.26502286
80Renal Fanconi syndrome (HP:0001994)2.26139229
81Cerebral edema (HP:0002181)2.25984116
82Selective tooth agenesis (HP:0001592)2.21985833
83Methylmalonic acidemia (HP:0002912)2.21838969
84Respiratory difficulties (HP:0002880)2.20783348
85Optic disc pallor (HP:0000543)2.19908823
86Progressive inability to walk (HP:0002505)2.19192488
87Nephrogenic diabetes insipidus (HP:0009806)2.17505519
88Lethargy (HP:0001254)2.17503180
89CNS demyelination (HP:0007305)2.17150637
90Abnormality of serine family amino acid metabolism (HP:0010894)2.16217712
91Abnormality of glycine metabolism (HP:0010895)2.16217712
92Patellar aplasia (HP:0006443)2.15544817
93Abnormality of the renal cortex (HP:0011035)2.14852708
94Pallor (HP:0000980)2.14086371
95IgM deficiency (HP:0002850)2.12423114
96Premature graying of hair (HP:0002216)2.12377800
97Abnormal rod and cone electroretinograms (HP:0008323)2.12004228
98Megaloblastic anemia (HP:0001889)2.11449435
99Congenital primary aphakia (HP:0007707)2.11344376
100Renal cortical cysts (HP:0000803)2.10360108
101Respiratory failure (HP:0002878)2.10347768
102Exertional dyspnea (HP:0002875)2.09688817
103Opisthotonus (HP:0002179)2.08969481
104Chromsome breakage (HP:0040012)2.07259413
105Hypothermia (HP:0002045)2.06607340
106Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06547230
107Aplasia/Hypoplasia of the patella (HP:0006498)2.03540577
108Aplasia/hypoplasia of the uterus (HP:0008684)2.02858744
109Abnormal spermatogenesis (HP:0008669)2.02817367
110Bone marrow hypocellularity (HP:0005528)2.02705238
111Chronic hepatic failure (HP:0100626)2.02561242
112Absent thumb (HP:0009777)2.02332254
113Attenuation of retinal blood vessels (HP:0007843)2.02180519
114Delusions (HP:0000746)2.02133576
115Gait imbalance (HP:0002141)2.02075487
116Petechiae (HP:0000967)2.01750941
117Myelodysplasia (HP:0002863)2.01410051
118Abnormality of the preputium (HP:0100587)2.01059674
119Abnormality of chromosome stability (HP:0003220)1.99865739
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97930327
121Myoglobinuria (HP:0002913)1.96762317
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.96435666
123Agnosia (HP:0010524)1.96036363
124Microvesicular hepatic steatosis (HP:0001414)1.95196320
125Meckel diverticulum (HP:0002245)1.95189184
126Focal motor seizures (HP:0011153)1.94892209
127Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94010830
12811 pairs of ribs (HP:0000878)1.93399144
129Occipital encephalocele (HP:0002085)1.92804779
130Agammaglobulinemia (HP:0004432)1.92749282
131Cellular immunodeficiency (HP:0005374)1.92672027
132Abnormality of the renal medulla (HP:0100957)1.92189079
133Progressive muscle weakness (HP:0003323)1.91953763
134Carpal bone hypoplasia (HP:0001498)1.90510389
135Emotional lability (HP:0000712)1.90273762
136Abnormality of the ileum (HP:0001549)1.89975892
137Abnormality of the renal collecting system (HP:0004742)1.89413833
138Vacuolated lymphocytes (HP:0001922)1.88439805
139Sparse eyelashes (HP:0000653)1.87681085
140Abnormality of pyrimidine metabolism (HP:0004353)1.87360640
141Cystic liver disease (HP:0006706)1.86509024
142Hypoglycemic coma (HP:0001325)1.85724338
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84744924
144Cerebral palsy (HP:0100021)1.84433338
145Sclerocornea (HP:0000647)1.84289480
146Abnormality of lateral ventricle (HP:0030047)1.80294894
147Lissencephaly (HP:0001339)1.80242585
148Stomatitis (HP:0010280)1.80173131
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.79035741
150Absent/shortened dynein arms (HP:0200106)1.79035741
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.78099716
152Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77363152
153Inability to walk (HP:0002540)1.75496388
154Abnormality of macular pigmentation (HP:0008002)1.75317176
155Abnormality of the labia minora (HP:0012880)1.71269009
156Severe visual impairment (HP:0001141)1.71068764
157Congenital hepatic fibrosis (HP:0002612)1.70199846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.45935098
2BUB14.42733018
3WEE13.67573356
4PLK43.27886913
5EIF2AK13.26237753
6STK163.04341116
7VRK22.88230268
8BCKDK2.70050412
9NME22.61752256
10TAOK32.54449327
11NUAK12.54021396
12BMPR1B2.53255150
13FRK2.48583797
14ACVR1B2.46333399
15TSSK62.39496951
16VRK12.19109445
17BRSK22.11257080
18ZAK2.06631240
19EIF2AK32.06417910
20PDK42.02465367
21PDK32.02465367
22WNK32.01970068
23TRIM281.96039984
24CDC71.92470726
25SRPK11.90615874
26NEK11.89417384
27PIM21.79139914
28CCNB11.66841565
29ADRBK21.61424044
30TESK21.60558214
31MAPK131.58567385
32INSRR1.56672914
33FLT31.54551835
34GRK11.50611414
35TGFBR11.49764932
36TTK1.48973898
37PLK11.46121322
38BRSK11.40560159
39PASK1.40362484
40NEK21.37055789
41CSNK1G31.35555576
42MAP2K31.35120167
43TLK11.29990625
44ATR1.29399631
45TESK11.28942877
46PLK31.23504097
47TAOK21.21060140
48DYRK31.20913339
49RPS6KB21.20230695
50CDK71.18712556
51CSNK1A1L1.16953477
52PDK21.15645059
53MKNK11.13197631
54AURKB1.12844734
55RPS6KA41.10635508
56ERBB31.09417970
57MAP3K41.06411203
58KDR1.05671389
59CSNK1G11.05136405
60MAPKAPK31.02676753
61BCR0.98758073
62EIF2AK20.97280143
63CDK40.97193387
64TNK20.96365487
65CDK190.92826420
66KIT0.92634016
67TAOK10.91987252
68IRAK30.90890686
69CSNK1G20.89999408
70ZAP700.86966511
71AURKA0.86438620
72BLK0.83888007
73LMTK20.83700770
74SCYL20.80218086
75PIM10.80008566
76MAP3K30.79426959
77CDK80.79290804
78CAMKK20.79091150
79NEK90.79018509
80MYLK0.78933422
81NME10.77575102
82CHEK20.74585537
83FES0.74010424
84MKNK20.73402977
85WNK40.72820121
86MAP3K110.72415765
87TEC0.72330014
88MAP4K10.72292073
89TXK0.71216219
90STK100.70501485
91MAP3K80.68205043
92BTK0.67609806
93CSNK2A10.66860315
94LYN0.66560009
95TGFBR20.64722931
96ITK0.64613719
97STK38L0.61644077
98BRAF0.61354843
99MAP2K70.60679251
100IRAK40.59705894
101MAPKAPK50.59154935
102GRK60.58641347
103BMPR20.58612966
104EPHA40.58506768
105MAP3K50.58447902
106CHEK10.58270787
107STK40.57610591
108GRK70.57604412
109CASK0.57075303
110TYK20.56960573
111PHKG20.56461682
112PHKG10.56461682
113MATK0.54813927
114PBK0.54123455
115PAK40.53656400
116PLK20.53573308
117AKT30.52566586
118IKBKB0.52020366
119DAPK10.51917689
120CSNK2A20.50248312
121YES10.49694839
122STK240.49621095
123EEF2K0.48946116
124PRKCQ0.47708826
125RPS6KB10.46780585
126ABL20.46649842
127OBSCN0.46554248
128CSF1R0.46350199
129MAP3K120.45578812
130SYK0.45520074
131TBK10.44307866
132MST40.44270770
133MAPK110.43758489
134CDK30.42200814
135MARK30.42100167
136TNIK0.42022084
137CSNK1A10.41157214
138PRKCE0.40597919
139ATM0.40462735
140RPS6KC10.40447721
141RPS6KL10.40447721
142ABL10.39395265
143PRKACB0.39306786
144MAP2K60.38315795
145DYRK20.38149798
146PRKCI0.37624601
147RPS6KA60.37409276
148ILK0.37401380
149PKN20.37380213
150JAK30.37049928
151RPS6KA50.36931358
152ADRBK10.36466929

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.32736522
2Proteasome_Homo sapiens_hsa030503.65924186
3Mismatch repair_Homo sapiens_hsa034303.38687659
4Ribosome_Homo sapiens_hsa030103.20277756
5RNA polymerase_Homo sapiens_hsa030203.02609045
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78906640
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.76368930
8Base excision repair_Homo sapiens_hsa034102.67230698
9Homologous recombination_Homo sapiens_hsa034402.64061063
10Pyrimidine metabolism_Homo sapiens_hsa002402.56828008
11Spliceosome_Homo sapiens_hsa030402.43762796
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38832031
13Nucleotide excision repair_Homo sapiens_hsa034202.31542807
14RNA transport_Homo sapiens_hsa030132.22834976
15One carbon pool by folate_Homo sapiens_hsa006702.19849265
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14834979
17Butanoate metabolism_Homo sapiens_hsa006502.01052394
18Asthma_Homo sapiens_hsa053101.96624412
19Cell cycle_Homo sapiens_hsa041101.82332643
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81601175
21Vitamin B6 metabolism_Homo sapiens_hsa007501.77230078
22Fanconi anemia pathway_Homo sapiens_hsa034601.71319053
23Phototransduction_Homo sapiens_hsa047441.63437966
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56867227
25Collecting duct acid secretion_Homo sapiens_hsa049661.55432727
26Type I diabetes mellitus_Homo sapiens_hsa049401.54564717
27Propanoate metabolism_Homo sapiens_hsa006401.53054343
28RNA degradation_Homo sapiens_hsa030181.51284473
29Allograft rejection_Homo sapiens_hsa053301.49792604
30Non-homologous end-joining_Homo sapiens_hsa034501.47614646
31Carbon metabolism_Homo sapiens_hsa012001.47403198
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45490161
33Folate biosynthesis_Homo sapiens_hsa007901.44762944
34Basal transcription factors_Homo sapiens_hsa030221.43764916
35Purine metabolism_Homo sapiens_hsa002301.43513904
36Parkinsons disease_Homo sapiens_hsa050121.41251766
37Autoimmune thyroid disease_Homo sapiens_hsa053201.38033748
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33023745
39Graft-versus-host disease_Homo sapiens_hsa053321.31718665
40Pentose phosphate pathway_Homo sapiens_hsa000301.30248148
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.29404082
42Oxidative phosphorylation_Homo sapiens_hsa001901.28104274
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26594741
44Protein export_Homo sapiens_hsa030601.25470726
45Biosynthesis of amino acids_Homo sapiens_hsa012301.24707134
46Pyruvate metabolism_Homo sapiens_hsa006201.22795369
47Huntingtons disease_Homo sapiens_hsa050161.19834020
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.17721952
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.16579321
50Rheumatoid arthritis_Homo sapiens_hsa053231.14233143
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10649573
52p53 signaling pathway_Homo sapiens_hsa041151.10600011
53Fatty acid degradation_Homo sapiens_hsa000711.06777611
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04544067
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04143143
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02627803
57Selenocompound metabolism_Homo sapiens_hsa004500.99807243
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99324914
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98784701
60Steroid biosynthesis_Homo sapiens_hsa001000.97644758
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95731541
62Epstein-Barr virus infection_Homo sapiens_hsa051690.92036555
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.90458507
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90304741
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88235484
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85915877
67Fatty acid metabolism_Homo sapiens_hsa012120.85297410
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83569270
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82299190
70Linoleic acid metabolism_Homo sapiens_hsa005910.79440817
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76856459
72Fructose and mannose metabolism_Homo sapiens_hsa000510.74488752
73Glutathione metabolism_Homo sapiens_hsa004800.73059662
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73037397
75Sulfur relay system_Homo sapiens_hsa041220.72700221
76Nitrogen metabolism_Homo sapiens_hsa009100.72251599
77Antigen processing and presentation_Homo sapiens_hsa046120.72087784
78Regulation of autophagy_Homo sapiens_hsa041400.71770338
79Peroxisome_Homo sapiens_hsa041460.70742175
80Fatty acid elongation_Homo sapiens_hsa000620.69762580
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.68948293
82mRNA surveillance pathway_Homo sapiens_hsa030150.68861978
83Ether lipid metabolism_Homo sapiens_hsa005650.67230189
84Metabolic pathways_Homo sapiens_hsa011000.66486283
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66161962
86Caffeine metabolism_Homo sapiens_hsa002320.64560350
87Galactose metabolism_Homo sapiens_hsa000520.64250873
88Sulfur metabolism_Homo sapiens_hsa009200.62367603
89Herpes simplex infection_Homo sapiens_hsa051680.61587818
90Legionellosis_Homo sapiens_hsa051340.60988687
91Primary immunodeficiency_Homo sapiens_hsa053400.57931714
92Cardiac muscle contraction_Homo sapiens_hsa042600.57924900
93Alzheimers disease_Homo sapiens_hsa050100.55676422
94Chemical carcinogenesis_Homo sapiens_hsa052040.55183604
95Thyroid cancer_Homo sapiens_hsa052160.54064889
96beta-Alanine metabolism_Homo sapiens_hsa004100.53778421
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51344439
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50952200
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49055695
100N-Glycan biosynthesis_Homo sapiens_hsa005100.48962055
101Staphylococcus aureus infection_Homo sapiens_hsa051500.47341348
102Lysosome_Homo sapiens_hsa041420.47093995
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46993617
104Systemic lupus erythematosus_Homo sapiens_hsa053220.46724398
105Olfactory transduction_Homo sapiens_hsa047400.45650406
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45416148
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.43248752
108PPAR signaling pathway_Homo sapiens_hsa033200.43232111
109Viral myocarditis_Homo sapiens_hsa054160.43190025
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41461050
111Retinol metabolism_Homo sapiens_hsa008300.39618622
112Viral carcinogenesis_Homo sapiens_hsa052030.39161922
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36269189
114Measles_Homo sapiens_hsa051620.34778194
115Phenylalanine metabolism_Homo sapiens_hsa003600.30943819
116Arachidonic acid metabolism_Homo sapiens_hsa005900.30754938
117HTLV-I infection_Homo sapiens_hsa051660.27848410
118Tryptophan metabolism_Homo sapiens_hsa003800.26739818
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.26012062
120Oocyte meiosis_Homo sapiens_hsa041140.26007456
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25605128
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25020223
123Other glycan degradation_Homo sapiens_hsa005110.23364915
124Apoptosis_Homo sapiens_hsa042100.22518079
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21790096
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21454900
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21228954
128Glycerolipid metabolism_Homo sapiens_hsa005610.21149081
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20708198
130Tyrosine metabolism_Homo sapiens_hsa003500.15607810
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.14724212
132Hematopoietic cell lineage_Homo sapiens_hsa046400.13889513
133Fatty acid biosynthesis_Homo sapiens_hsa000610.13607095
134Arginine and proline metabolism_Homo sapiens_hsa003300.12157193
135Fat digestion and absorption_Homo sapiens_hsa049750.10909725
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10364071
137Acute myeloid leukemia_Homo sapiens_hsa052210.10111948

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »