ATPIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.12360455
2ATP synthesis coupled proton transport (GO:0015986)7.83675530
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.83675530
4establishment of protein localization to mitochondrial membrane (GO:0090151)6.93121730
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.50583066
6viral transcription (GO:0019083)6.43453183
7translational termination (GO:0006415)6.14344791
8respiratory electron transport chain (GO:0022904)6.03466747
9ribosomal small subunit biogenesis (GO:0042274)5.91395034
10electron transport chain (GO:0022900)5.90284291
11DNA deamination (GO:0045006)5.77165502
12protein neddylation (GO:0045116)5.39506074
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.36001856
14cotranslational protein targeting to membrane (GO:0006613)5.35846624
15protein targeting to ER (GO:0045047)5.29259762
16translational elongation (GO:0006414)5.26344534
17ribosomal small subunit assembly (GO:0000028)5.10317604
18establishment of protein localization to endoplasmic reticulum (GO:0072599)5.03241829
19protein localization to endoplasmic reticulum (GO:0070972)5.01025428
20cellular protein complex disassembly (GO:0043624)4.99648644
21viral life cycle (GO:0019058)4.94104176
22translational initiation (GO:0006413)4.72624352
23chaperone-mediated protein transport (GO:0072321)4.72116854
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.63302019
25proline biosynthetic process (GO:0006561)4.51682128
26protein complex biogenesis (GO:0070271)4.29816085
27protein complex disassembly (GO:0043241)4.25786251
28oxidative phosphorylation (GO:0006119)4.19102410
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.14627602
30NADH dehydrogenase complex assembly (GO:0010257)4.14627602
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14627602
32proteasome assembly (GO:0043248)4.13779276
33maturation of SSU-rRNA (GO:0030490)4.09731820
34ribosomal large subunit biogenesis (GO:0042273)4.06542079
35macromolecular complex disassembly (GO:0032984)4.03657378
36translation (GO:0006412)4.02682752
37mitochondrial respiratory chain complex assembly (GO:0033108)4.02494206
38cytochrome complex assembly (GO:0017004)3.97155639
39transcription from mitochondrial promoter (GO:0006390)3.95178884
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.94528792
41hydrogen ion transmembrane transport (GO:1902600)3.92658096
42GTP biosynthetic process (GO:0006183)3.91542232
43replication fork processing (GO:0031297)3.89305692
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.89088644
45ATP biosynthetic process (GO:0006754)3.88387619
46protein targeting to mitochondrion (GO:0006626)3.87777409
47viral mRNA export from host cell nucleus (GO:0046784)3.84867474
48establishment of protein localization to mitochondrion (GO:0072655)3.82870727
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.77179492
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.73756440
51cullin deneddylation (GO:0010388)3.65077933
52inner mitochondrial membrane organization (GO:0007007)3.64031105
53protein-cofactor linkage (GO:0018065)3.62888873
54regulation of mitochondrial translation (GO:0070129)3.61722712
55UTP biosynthetic process (GO:0006228)3.53588563
56formation of translation preinitiation complex (GO:0001731)3.53296993
57protein localization to mitochondrion (GO:0070585)3.52826316
58ribonucleoside triphosphate biosynthetic process (GO:0009201)3.50583901
59dopamine transport (GO:0015872)3.48966714
60protein targeting to membrane (GO:0006612)3.46451964
61telomere maintenance via semi-conservative replication (GO:0032201)3.43733978
62maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42490235
63establishment of integrated proviral latency (GO:0075713)3.41494429
64proline metabolic process (GO:0006560)3.39272747
65nuclear-transcribed mRNA catabolic process (GO:0000956)3.37427553
66aerobic respiration (GO:0009060)3.33755757
67protein deneddylation (GO:0000338)3.33099075
68proton transport (GO:0015992)3.32337264
69GDP-mannose metabolic process (GO:0019673)3.31671845
70chromatin remodeling at centromere (GO:0031055)3.30172360
71ribonucleoprotein complex biogenesis (GO:0022613)3.23011187
72purine nucleoside monophosphate biosynthetic process (GO:0009127)3.22704714
73purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.22704714
74hydrogen transport (GO:0006818)3.22597002
75CENP-A containing nucleosome assembly (GO:0034080)3.20647153
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20540754
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20415155
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20415155
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19909363
80cellular component biogenesis (GO:0044085)3.19025492
81termination of RNA polymerase III transcription (GO:0006386)3.17428434
82transcription elongation from RNA polymerase III promoter (GO:0006385)3.17428434
83mRNA catabolic process (GO:0006402)3.16794531
84regulation of oxidative phosphorylation (GO:0002082)3.16334864
85water-soluble vitamin biosynthetic process (GO:0042364)3.11144333
86mitochondrial transport (GO:0006839)3.11037044
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09136972
88guanosine-containing compound biosynthetic process (GO:1901070)3.07424903
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06343793
90base-excision repair, AP site formation (GO:0006285)3.06227711
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05773290
92rRNA modification (GO:0000154)3.05496714
93pyrimidine nucleotide catabolic process (GO:0006244)3.04505008
94pseudouridine synthesis (GO:0001522)3.01945814
95nucleoside triphosphate biosynthetic process (GO:0009142)3.00005519
96nucleotide-excision repair, DNA gap filling (GO:0006297)2.99330353
97DNA damage response, detection of DNA damage (GO:0042769)2.99133189
98rRNA processing (GO:0006364)2.98739662
99respiratory chain complex IV assembly (GO:0008535)2.96590755
100negative regulation of microtubule polymerization (GO:0031115)2.96486609
101RNA catabolic process (GO:0006401)2.96337815
102negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96305873
103spliceosomal snRNP assembly (GO:0000387)2.95159296
104UTP metabolic process (GO:0046051)2.95096398
105intracellular protein transmembrane import (GO:0044743)2.93792171
106rRNA metabolic process (GO:0016072)2.90619965
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88954066
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87394527
109regulation of cellular amino acid metabolic process (GO:0006521)2.86106448
110pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.85955505
111nucleoside monophosphate biosynthetic process (GO:0009124)2.85257897
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82999340
113CTP metabolic process (GO:0046036)2.82969751
114CTP biosynthetic process (GO:0006241)2.82969751
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81398093
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81398093
117ribonucleoside monophosphate biosynthetic process (GO:0009156)2.80641305
118kinetochore assembly (GO:0051382)2.80546783
119establishment of viral latency (GO:0019043)2.80092749
120aldehyde catabolic process (GO:0046185)2.79923577
121DNA strand elongation involved in DNA replication (GO:0006271)2.78962225
122negative regulation of ligase activity (GO:0051352)2.78679894
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76936675
124deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73972467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_18555785_ChIP-Seq_MESCs_Mouse4.34372883
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10996637
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.93436584
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77716082
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72134316
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.71574566
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.66391124
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.57166900
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.55562199
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.15149559
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13574900
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.11764143
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97697742
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96514837
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.71109171
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55398569
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54147652
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.52195836
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42442235
20TTF2_22483619_ChIP-Seq_HELA_Human2.41293194
21DCP1A_22483619_ChIP-Seq_HELA_Human2.40505202
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34451439
23XRN2_22483619_ChIP-Seq_HELA_Human2.28810971
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26782354
25VDR_23849224_ChIP-Seq_CD4+_Human2.25250453
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21651299
27* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.18177874
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.03745685
29* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01498410
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.88599364
31GABP_19822575_ChIP-Seq_HepG2_Human1.88278812
32EZH2_22144423_ChIP-Seq_EOC_Human1.83813405
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79942370
34ELK1_19687146_ChIP-ChIP_HELA_Human1.76795000
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71039191
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70076361
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68343207
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64369981
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62394526
40FOXP3_21729870_ChIP-Seq_TREG_Human1.61933945
41* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54719246
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53935303
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48544040
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48524074
45CTCF_18555785_ChIP-Seq_MESCs_Mouse1.43455578
46IRF1_19129219_ChIP-ChIP_H3396_Human1.43312671
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.42908532
48* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42214961
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39614124
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35490785
51VDR_22108803_ChIP-Seq_LS180_Human1.33916131
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32319742
53* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32068695
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.30390712
55E2F7_22180533_ChIP-Seq_HELA_Human1.29860463
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29813499
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29752251
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27994660
59* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26400971
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25877980
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25205741
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24511002
63* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23113802
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20048309
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18525703
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18121235
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18105207
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17555162
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17325092
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16974886
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16356478
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16069211
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14049476
74MYC_18940864_ChIP-ChIP_HL60_Human1.11801861
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09471777
76* STAT1_20625510_ChIP-Seq_HELA_Human1.07462336
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06751296
78* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06706115
79TP53_22573176_ChIP-Seq_HFKS_Human1.06136157
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04104748
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03463474
82ZNF274_21170338_ChIP-Seq_K562_Hela1.03411970
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03087522
84ZNF263_19887448_ChIP-Seq_K562_Human1.01789735
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.00428111
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00367901
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99385132
88YY1_22570637_ChIP-Seq_MALME-3M_Human0.98807818
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98179929
90TET1_21451524_ChIP-Seq_MESCs_Mouse0.96754577
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96723256
92OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96491639
93EWS_26573619_Chip-Seq_HEK293_Human0.96170020
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.94871379
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94590168
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94373039
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93335735
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92384623
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92137432
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92137432
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92137432
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90974982
103* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89617524
104REST_21632747_ChIP-Seq_MESCs_Mouse0.89328739
105CIITA_25753668_ChIP-Seq_RAJI_Human0.88176711
106FOXP1_21924763_ChIP-Seq_HESCs_Human0.84852081
107SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84742055
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83646822
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81579527
110POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.80482429
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80359369
112* NANOG_16153702_ChIP-ChIP_HESCs_Human0.80338003
113KDM5A_27292631_Chip-Seq_BREAST_Human0.80188760
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79795714
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79532333
116VDR_21846776_ChIP-Seq_THP-1_Human0.78724492
117FUS_26573619_Chip-Seq_HEK293_Human0.78578762
118REST_18959480_ChIP-ChIP_MESCs_Mouse0.78199714
119PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77932835
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77567835
121E2F1_17053090_ChIP-ChIP_MCF-7_Human0.77489108
122IGF1R_20145208_ChIP-Seq_DFB_Human0.76555649
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74602604
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73942311
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73899108
126NANOG_20526341_ChIP-Seq_ESCs_Human0.71944679
127HTT_18923047_ChIP-ChIP_STHdh_Human0.71599137
128NCOR_22424771_ChIP-Seq_293T_Human0.70986477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.31496849
2MP0008057_abnormal_DNA_replication3.81253929
3MP0003880_abnormal_central_pattern3.29630578
4MP0001529_abnormal_vocalization3.27828503
5MP0006276_abnormal_autonomic_nervous2.86472445
6MP0005171_absent_coat_pigmentation2.66582523
7MP0003186_abnormal_redox_activity2.47320339
8MP0006072_abnormal_retinal_apoptosis2.43153530
9MP0005174_abnormal_tail_pigmentation2.35185859
10MP0003787_abnormal_imprinting2.23477736
11MP0001905_abnormal_dopamine_level2.21864854
12MP0003123_paternal_imprinting2.21683778
13MP0008995_early_reproductive_senescence2.09744282
14MP0003656_abnormal_erythrocyte_physiolo2.04800672
15MP0002736_abnormal_nociception_after2.04448458
16MP0001968_abnormal_touch/_nociception2.04326066
17MP0001970_abnormal_pain_threshold2.04295770
18MP0002733_abnormal_thermal_nociception2.04284152
19MP0004142_abnormal_muscle_tone1.98256113
20MP0003806_abnormal_nucleotide_metabolis1.94656221
21MP0002163_abnormal_gland_morphology1.93532387
22MP0002735_abnormal_chemical_nociception1.93385990
23MP0005645_abnormal_hypothalamus_physiol1.87792368
24MP0004145_abnormal_muscle_electrophysio1.87770486
25MP0001188_hyperpigmentation1.83633812
26MP0004957_abnormal_blastocyst_morpholog1.82130684
27MP0008875_abnormal_xenobiotic_pharmacok1.81438230
28MP0009046_muscle_twitch1.81240759
29MP0006036_abnormal_mitochondrial_physio1.77695289
30MP0003121_genomic_imprinting1.76772679
31MP0002572_abnormal_emotion/affect_behav1.71847417
32MP0003693_abnormal_embryo_hatching1.70498945
33MP0002751_abnormal_autonomic_nervous1.63666552
34MP0008932_abnormal_embryonic_tissue1.59765919
35MP0003786_premature_aging1.58607591
36MP0000015_abnormal_ear_pigmentation1.56776877
37MP0001440_abnormal_grooming_behavior1.56116798
38MP0002653_abnormal_ependyma_morphology1.54658379
39MP0002638_abnormal_pupillary_reflex1.54408902
40MP0005646_abnormal_pituitary_gland1.53849581
41MP0009745_abnormal_behavioral_response1.50882460
42MP0003011_delayed_dark_adaptation1.50778824
43MP0010094_abnormal_chromosome_stability1.50162499
44MP0002734_abnormal_mechanical_nocicepti1.49541581
45MP0003635_abnormal_synaptic_transmissio1.48980676
46MP0002064_seizures1.48314738
47MP0005379_endocrine/exocrine_gland_phen1.47229568
48MP0002272_abnormal_nervous_system1.45428424
49MP0010386_abnormal_urinary_bladder1.44593196
50MP0002822_catalepsy1.41780716
51MP0002009_preneoplasia1.40740604
52MP0006035_abnormal_mitochondrial_morpho1.39608499
53MP0002184_abnormal_innervation1.39583433
54MP0003111_abnormal_nucleus_morphology1.38817240
55MP0005084_abnormal_gallbladder_morpholo1.38682280
56MP0002160_abnormal_reproductive_system1.38454301
57MP0006292_abnormal_olfactory_placode1.36040733
58MP0002063_abnormal_learning/memory/cond1.33713199
59MP0004147_increased_porphyrin_level1.33227606
60MP0008058_abnormal_DNA_repair1.32820657
61MP0002102_abnormal_ear_morphology1.32193122
62MP0005423_abnormal_somatic_nervous1.31540160
63MP0005636_abnormal_mineral_homeostasis1.31315847
64MP0004924_abnormal_behavior1.30211328
65MP0005386_behavior/neurological_phenoty1.30211328
66MP0010030_abnormal_orbit_morphology1.29994609
67MP0004133_heterotaxia1.23743176
68MP0002067_abnormal_sensory_capabilities1.23409731
69MP0005075_abnormal_melanosome_morpholog1.22855080
70MP0001727_abnormal_embryo_implantation1.19410031
71MP0002938_white_spotting1.18981031
72MP0008872_abnormal_physiological_respon1.17640430
73MP0005551_abnormal_eye_electrophysiolog1.16684084
74MP0008877_abnormal_DNA_methylation1.15714685
75MP0001764_abnormal_homeostasis1.14306768
76MP0003122_maternal_imprinting1.12857575
77MP0008789_abnormal_olfactory_epithelium1.12323230
78MP0001986_abnormal_taste_sensitivity1.12203213
79MP0005332_abnormal_amino_acid1.11568138
80MP0002876_abnormal_thyroid_physiology1.11102071
81MP0005397_hematopoietic_system_phenotyp1.09369709
82MP0001545_abnormal_hematopoietic_system1.09369709
83MP0002277_abnormal_respiratory_mucosa1.09332014
84MP0002837_dystrophic_cardiac_calcinosis1.08789540
85MP0000490_abnormal_crypts_of1.08266867
86MP0003136_yellow_coat_color1.06825549
87MP0005389_reproductive_system_phenotype1.06560049
88MP0002132_abnormal_respiratory_system1.04784313
89MP0004859_abnormal_synaptic_plasticity1.04656244
90MP0000538_abnormal_urinary_bladder1.00669854
91MP0004742_abnormal_vestibular_system0.99348957
92MP0003567_abnormal_fetal_cardiomyocyte0.99017801
93MP0000778_abnormal_nervous_system0.98651489
94MP0005499_abnormal_olfactory_system0.97164332
95MP0005394_taste/olfaction_phenotype0.97164332
96MP0002282_abnormal_trachea_morphology0.96283210
97MP0002210_abnormal_sex_determination0.95270806
98MP0003283_abnormal_digestive_organ0.93614242
99MP0000751_myopathy0.93354631
100MP0001293_anophthalmia0.92271248
101MP0004270_analgesia0.92252922
102MP0001919_abnormal_reproductive_system0.91348096
103MP0003137_abnormal_impulse_conducting0.90184434
104MP0003646_muscle_fatigue0.88923073
105MP0004019_abnormal_vitamin_homeostasis0.88725358
106MP0009697_abnormal_copulation0.88556317
107MP0000955_abnormal_spinal_cord0.86512027
108MP0005253_abnormal_eye_physiology0.86351856
109MP0000462_abnormal_digestive_system0.86343600
110MP0000631_abnormal_neuroendocrine_gland0.85316687
111MP0003315_abnormal_perineum_morphology0.84747311
112MP0000372_irregular_coat_pigmentation0.84627448
113MP0002557_abnormal_social/conspecific_i0.83526060
114MP0002234_abnormal_pharynx_morphology0.82689507
115MP0001485_abnormal_pinna_reflex0.82032311
116MP0003718_maternal_effect0.81313981
117MP0004811_abnormal_neuron_physiology0.81268281
118MP0003077_abnormal_cell_cycle0.81119083
119MP0001929_abnormal_gametogenesis0.80891066
120MP0001984_abnormal_olfaction0.80192578
121MP0008007_abnormal_cellular_replicative0.79837719
122MP0002066_abnormal_motor_capabilities/c0.79627955
123MP0005409_darkened_coat_color0.79225333
124MP0003698_abnormal_male_reproductive0.79005934
125MP0005266_abnormal_metabolism0.78791463
126MP0000049_abnormal_middle_ear0.78257323
127MP0002752_abnormal_somatic_nervous0.77590214
128MP0004233_abnormal_muscle_weight0.76978524
129MP0009278_abnormal_bone_marrow0.76773712
130MP0001145_abnormal_male_reproductive0.76572969
131MP0002882_abnormal_neuron_morphology0.76442367
132MP0000358_abnormal_cell_content/0.76415059
133MP0000653_abnormal_sex_gland0.76295654
134MP0005410_abnormal_fertilization0.73625846
135MP0001486_abnormal_startle_reflex0.69977551

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.51897080
2Abnormality of cells of the erythroid lineage (HP:0012130)6.45276296
3Abnormal mitochondria in muscle tissue (HP:0008316)5.84125720
4Abnormal number of erythroid precursors (HP:0012131)5.77394932
5Mitochondrial inheritance (HP:0001427)5.65038853
6Progressive macrocephaly (HP:0004481)5.39103070
7Acute encephalopathy (HP:0006846)5.07202284
8Increased hepatocellular lipid droplets (HP:0006565)4.66356128
9Increased CSF lactate (HP:0002490)4.65489387
10Exertional dyspnea (HP:0002875)4.41235124
11Hepatocellular necrosis (HP:0001404)4.36819938
12Lipid accumulation in hepatocytes (HP:0006561)3.96515553
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.94247837
14Reticulocytopenia (HP:0001896)3.85713511
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.81694516
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.81694516
17Renal Fanconi syndrome (HP:0001994)3.63979808
18Pallor (HP:0000980)3.55996794
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.53670034
20Increased intramyocellular lipid droplets (HP:0012240)3.52569711
21Hepatic necrosis (HP:0002605)3.45836006
22Macrocytic anemia (HP:0001972)3.44623982
23Exercise intolerance (HP:0003546)3.38681575
24Myokymia (HP:0002411)3.35658179
25Abnormality of the heme biosynthetic pathway (HP:0010472)3.33144663
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.20343510
27Optic disc pallor (HP:0000543)3.19791318
28Abnormal hemoglobin (HP:0011902)3.19563300
29Cerebral edema (HP:0002181)3.16419859
30Respiratory failure (HP:0002878)3.12438074
31Concave nail (HP:0001598)3.09829243
32Orthostatic hypotension (HP:0001278)3.08588913
333-Methylglutaconic aciduria (HP:0003535)2.98854551
34Lactic acidosis (HP:0003128)2.97812087
35Increased serum lactate (HP:0002151)2.92725913
36Leukodystrophy (HP:0002415)2.80539668
37Increased muscle lipid content (HP:0009058)2.76342546
38Abnormal respiratory motile cilium physiology (HP:0012261)2.70698221
39Pancreatic fibrosis (HP:0100732)2.67502013
40Hypothermia (HP:0002045)2.62695850
41Lethargy (HP:0001254)2.54873309
42Limb dystonia (HP:0002451)2.53064118
43Abnormal respiratory motile cilium morphology (HP:0005938)2.52878629
44Abnormal respiratory epithelium morphology (HP:0012253)2.52878629
45Increased IgM level (HP:0003496)2.50470599
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49575427
47Abnormality of placental membranes (HP:0011409)2.45885541
48Amniotic constriction ring (HP:0009775)2.45885541
49Respiratory difficulties (HP:0002880)2.44766266
50Abnormal ciliary motility (HP:0012262)2.42085133
51Glycosuria (HP:0003076)2.40036350
52Abnormality of urine glucose concentration (HP:0011016)2.40036350
53Rectal fistula (HP:0100590)2.39739631
54Rectovaginal fistula (HP:0000143)2.39739631
55Emotional lability (HP:0000712)2.38198603
56Abnormality of alanine metabolism (HP:0010916)2.37277804
57Hyperalaninemia (HP:0003348)2.37277804
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37277804
59Absent/shortened dynein arms (HP:0200106)2.35009341
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.35009341
61Hyperglycinemia (HP:0002154)2.34682723
62Abnormality of renal resorption (HP:0011038)2.31133572
63Rhinitis (HP:0012384)2.28093692
64Abnormality of midbrain morphology (HP:0002418)2.27257453
65Molar tooth sign on MRI (HP:0002419)2.27257453
66Dysautonomia (HP:0002459)2.26513123
67Abnormal autonomic nervous system physiology (HP:0012332)2.25685998
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25683814
69Pancreatic cysts (HP:0001737)2.22331361
70Chronic bronchitis (HP:0004469)2.21895411
71Absent thumb (HP:0009777)2.20287139
72Facial hemangioma (HP:0000329)2.19887710
73Generalized aminoaciduria (HP:0002909)2.18781045
74True hermaphroditism (HP:0010459)2.18652633
75Methylmalonic acidemia (HP:0002912)2.17425802
76Neuroendocrine neoplasm (HP:0100634)2.16092289
77Hypokinesia (HP:0002375)2.16017049
78Methylmalonic aciduria (HP:0012120)2.14353810
79Type I transferrin isoform profile (HP:0003642)2.10133886
80Hyperphosphaturia (HP:0003109)2.08223469
81Rib fusion (HP:0000902)2.08192708
82Tongue fasciculations (HP:0001308)2.08121074
83Abnormality of the labia minora (HP:0012880)2.08103349
84Gait imbalance (HP:0002141)2.06586571
85Poor suck (HP:0002033)2.06461730
86Medial flaring of the eyebrow (HP:0010747)2.04552769
87Sclerocornea (HP:0000647)2.04238880
88Short chin (HP:0000331)2.01890862
89Aplastic anemia (HP:0001915)2.01671476
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99324437
91Dicarboxylic aciduria (HP:0003215)1.99324437
92Pheochromocytoma (HP:0002666)1.98628222
93Vaginal fistula (HP:0004320)1.98335033
94Diaphragmatic weakness (HP:0009113)1.97382546
95X-linked dominant inheritance (HP:0001423)1.96571753
96Degeneration of anterior horn cells (HP:0002398)1.95678585
97Abnormality of the anterior horn cell (HP:0006802)1.95678585
98Cerebral hypomyelination (HP:0006808)1.95645962
99Gout (HP:0001997)1.94144571
100Poikiloderma (HP:0001029)1.93876231
101Congenital primary aphakia (HP:0007707)1.93599100
102Abnormality of serum amino acid levels (HP:0003112)1.92754224
103Microvesicular hepatic steatosis (HP:0001414)1.92156252
104Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91880052
105CNS demyelination (HP:0007305)1.91289506
106Atonic seizures (HP:0010819)1.91148330
107Popliteal pterygium (HP:0009756)1.89858796
108Delusions (HP:0000746)1.87027831
109Increased serum pyruvate (HP:0003542)1.85057488
110Abnormality of glycolysis (HP:0004366)1.85057488
111Pustule (HP:0200039)1.84811334
112Visual hallucinations (HP:0002367)1.83963778
113Nephrogenic diabetes insipidus (HP:0009806)1.82909440
114Oral leukoplakia (HP:0002745)1.82120367
115Median cleft lip (HP:0000161)1.79007414
116Muscle fibrillation (HP:0010546)1.78251992
117Nephronophthisis (HP:0000090)1.77465238
118Vomiting (HP:0002013)1.77142109
119Colon cancer (HP:0003003)1.75707537
120Pancytopenia (HP:0001876)1.73460461
121Febrile seizures (HP:0002373)1.72991135
122Intestinal fistula (HP:0100819)1.72379338
123Male pseudohermaphroditism (HP:0000037)1.71643925
124Muscle fiber atrophy (HP:0100295)1.68060285
125Absence seizures (HP:0002121)1.67079579
126Congenital, generalized hypertrichosis (HP:0004540)1.66558664
127Redundant skin (HP:0001582)1.66492162
128Abnormal number of incisors (HP:0011064)1.65321329
129Patellar aplasia (HP:0006443)1.63736079
130Premature graying of hair (HP:0002216)1.63397692
131Hypoplasia of the radius (HP:0002984)1.63162206
132Progressive microcephaly (HP:0000253)1.62799868
133Testicular atrophy (HP:0000029)1.62770975
134Abnormal urine phosphate concentration (HP:0012599)1.61745276
135Cutaneous photosensitivity (HP:0000992)1.60747904
136Blindness (HP:0000618)1.60476998
137Diminished movement (HP:0002374)1.59936134
138Occipital encephalocele (HP:0002085)1.59773538
139Severe visual impairment (HP:0001141)1.59084531
140Abnormality of magnesium homeostasis (HP:0004921)1.58367851
141Focal motor seizures (HP:0011153)1.57818036
142Abnormal protein N-linked glycosylation (HP:0012347)1.57467651
143Abnormal protein glycosylation (HP:0012346)1.57467651
144Abnormal glycosylation (HP:0012345)1.57467651
145Myotonia (HP:0002486)1.57294263
146Type 2 muscle fiber atrophy (HP:0003554)1.56241322
147Abnormality of reticulocytes (HP:0004312)1.52625268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.00648297
2PIM23.27417604
3MAPK153.24029533
4NME23.19380692
5MAP3K122.98227490
6STK162.82072406
7NME12.78760898
8MAP3K62.71889509
9BCKDK2.69711855
10UHMK12.53503086
11NEK12.52118222
12DAPK12.47925466
13MAP3K112.39156194
14ZAK2.30443701
15MATK2.22807292
16GRK52.22603781
17FGR2.09015309
18VRK12.00807441
19ICK1.99315800
20DDR21.92247204
21TESK21.91256542
22ARAF1.88595208
23MAP4K21.82561041
24NUAK11.79654887
25PINK11.78750346
26YES11.72807015
27CDK191.68659012
28PBK1.66346713
29BUB11.65245256
30TLK11.64775226
31GRK71.63308459
32WEE11.49469591
33MAP2K71.40393791
34PDK21.40230028
35TTK1.37014300
36PLK41.36762363
37EIF2AK11.32981238
38DYRK21.31959504
39TNIK1.27130735
40DYRK31.24550651
41PLK31.24357454
42PNCK1.21225509
43KDR1.18623133
44GRK11.18221106
45CSNK1G21.17901687
46CASK1.17220378
47MST41.16263572
48CDK71.15514137
49MARK11.05010823
50MYLK1.04437627
51MAPK131.01337745
52TESK11.00827125
53MAPKAPK50.99751894
54NTRK30.97016637
55MAP3K40.96744958
56MUSK0.96601494
57BMPR1B0.92869753
58PRKCG0.92304203
59ADRBK20.92274436
60CDK80.89969563
61DYRK1B0.89715377
62RPS6KL10.89062506
63RPS6KC10.89062506
64RAF10.88846627
65CAMK2B0.88825350
66INSRR0.88715755
67AURKA0.87568619
68SRPK10.86315450
69ATR0.86224087
70RPS6KA50.84987679
71CSNK1A1L0.84485277
72ADRBK10.82579815
73RPS6KB20.82459168
74TAF10.79759139
75PRKD20.78691282
76EIF2AK30.77269867
77RIPK40.76408589
78BRSK10.76284779
79MAP3K90.76061853
80CSNK2A10.74294031
81PLK10.72676012
82RPS6KA60.71334708
83CSNK2A20.70522448
84NTRK20.70301502
85CAMK2A0.68875711
86CDC70.67572452
87CHEK20.66136172
88CDK11A0.65915373
89BRAF0.65117167
90PIM10.64945354
91TRIM280.64830243
92CSNK1E0.64543717
93PHKG20.64528173
94PHKG10.64528173
95ABL20.62825784
96OBSCN0.62814886
97LIMK10.62563494
98MINK10.62475664
99TYRO30.61859818
100OXSR10.61637849
101CSNK1G30.60805399
102MAPK40.60685060
103CDK150.59681231
104WNK30.59281297
105CDK180.59100833
106CDK140.56262235
107GRK60.56016761
108ILK0.55465544
109CSNK1A10.54880183
110LRRK20.51865914
111TXK0.51089154
112CAMK2D0.50789179
113WNK40.50486054
114CAMK2G0.48654510
115DAPK30.47205168
116STK40.45847123
117PAK30.45716061
118NEK20.43533615
119ATM0.43421555
120CSNK1G10.42497795
121MAPKAPK30.42318364
122PLK20.42195555
123SCYL20.42159099
124ACVR1B0.40267736
125PAK10.40096981
126LYN0.39255111
127PRKCA0.38587169
128PRKCI0.38376192
129CHEK10.37659915
130AURKB0.36778691
131CCNB10.36746165
132PRKACA0.36417927
133CDK50.36344825
134ALK0.36140455
135BRSK20.36091696
136MKNK20.34032794
137NTRK10.34000568
138TRPM70.33726218

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.80635919
2Ribosome_Homo sapiens_hsa030105.49080345
3Parkinsons disease_Homo sapiens_hsa050125.14187264
4Huntingtons disease_Homo sapiens_hsa050163.80836532
5Alzheimers disease_Homo sapiens_hsa050103.78189137
6Proteasome_Homo sapiens_hsa030503.40897633
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.02560055
8Mismatch repair_Homo sapiens_hsa034302.72244823
9DNA replication_Homo sapiens_hsa030302.65450630
10RNA polymerase_Homo sapiens_hsa030202.60532581
11Cardiac muscle contraction_Homo sapiens_hsa042602.50770771
12Spliceosome_Homo sapiens_hsa030401.98048915
13Base excision repair_Homo sapiens_hsa034101.92746465
14Protein export_Homo sapiens_hsa030601.79853264
15Nucleotide excision repair_Homo sapiens_hsa034201.79525246
16Collecting duct acid secretion_Homo sapiens_hsa049661.76072920
17Homologous recombination_Homo sapiens_hsa034401.65565389
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65391216
19Pyrimidine metabolism_Homo sapiens_hsa002401.64938395
20One carbon pool by folate_Homo sapiens_hsa006701.55284579
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53976262
22Nicotine addiction_Homo sapiens_hsa050331.31663655
23Propanoate metabolism_Homo sapiens_hsa006401.30387175
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16674111
25RNA transport_Homo sapiens_hsa030131.14549037
26Synaptic vesicle cycle_Homo sapiens_hsa047211.11321338
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06622118
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05919918
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.04322783
30Fanconi anemia pathway_Homo sapiens_hsa034601.02856357
31Nitrogen metabolism_Homo sapiens_hsa009101.01179960
32Vibrio cholerae infection_Homo sapiens_hsa051100.96581582
33Butanoate metabolism_Homo sapiens_hsa006500.95802831
34Peroxisome_Homo sapiens_hsa041460.93532508
35Sulfur relay system_Homo sapiens_hsa041220.93070565
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84452505
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82851348
38Basal transcription factors_Homo sapiens_hsa030220.81170224
39Purine metabolism_Homo sapiens_hsa002300.80769605
40Carbon metabolism_Homo sapiens_hsa012000.79359181
41RNA degradation_Homo sapiens_hsa030180.78587965
42Serotonergic synapse_Homo sapiens_hsa047260.77812782
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77408932
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77188650
45Taste transduction_Homo sapiens_hsa047420.73595587
46Chemical carcinogenesis_Homo sapiens_hsa052040.73259750
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73002903
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72390548
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69991980
50Alcoholism_Homo sapiens_hsa050340.69431109
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68000471
52Biosynthesis of amino acids_Homo sapiens_hsa012300.65719120
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63758701
54Tryptophan metabolism_Homo sapiens_hsa003800.61145392
55Amphetamine addiction_Homo sapiens_hsa050310.60182859
56Metabolic pathways_Homo sapiens_hsa011000.59021107
57Fatty acid biosynthesis_Homo sapiens_hsa000610.58507649
58Phototransduction_Homo sapiens_hsa047440.58355689
59beta-Alanine metabolism_Homo sapiens_hsa004100.57914452
60Fatty acid degradation_Homo sapiens_hsa000710.56508084
61Oocyte meiosis_Homo sapiens_hsa041140.56061514
62Cell cycle_Homo sapiens_hsa041100.55832760
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55091075
64Systemic lupus erythematosus_Homo sapiens_hsa053220.54566759
65Steroid biosynthesis_Homo sapiens_hsa001000.54122466
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53490276
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53427036
68Vitamin B6 metabolism_Homo sapiens_hsa007500.53353221
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53131310
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51775669
71Fatty acid metabolism_Homo sapiens_hsa012120.51743185
72Retinol metabolism_Homo sapiens_hsa008300.51680028
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51562877
74mRNA surveillance pathway_Homo sapiens_hsa030150.51437882
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51026307
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.50342247
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47805943
78Dopaminergic synapse_Homo sapiens_hsa047280.47767620
79Gap junction_Homo sapiens_hsa045400.46919341
80Folate biosynthesis_Homo sapiens_hsa007900.46789865
81Caffeine metabolism_Homo sapiens_hsa002320.46116684
82Glutathione metabolism_Homo sapiens_hsa004800.45874870
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45532279
84GABAergic synapse_Homo sapiens_hsa047270.44358542
85p53 signaling pathway_Homo sapiens_hsa041150.43259721
86Phagosome_Homo sapiens_hsa041450.42503046
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.41816052
88Selenocompound metabolism_Homo sapiens_hsa004500.40904053
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40831232
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.40510538
91Long-term depression_Homo sapiens_hsa047300.39762653
92Fat digestion and absorption_Homo sapiens_hsa049750.38754486
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37592705
94Epstein-Barr virus infection_Homo sapiens_hsa051690.37581723
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37351572
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37007075
97Non-homologous end-joining_Homo sapiens_hsa034500.36854198
98Arginine and proline metabolism_Homo sapiens_hsa003300.36185944
99Arginine biosynthesis_Homo sapiens_hsa002200.35456430
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34317023
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33705106
102Rheumatoid arthritis_Homo sapiens_hsa053230.33085623
103Hedgehog signaling pathway_Homo sapiens_hsa043400.33048402
104Regulation of autophagy_Homo sapiens_hsa041400.32746804
105Long-term potentiation_Homo sapiens_hsa047200.32258789
106Morphine addiction_Homo sapiens_hsa050320.31706613
107Olfactory transduction_Homo sapiens_hsa047400.31355647
108Arachidonic acid metabolism_Homo sapiens_hsa005900.30802953
109Sulfur metabolism_Homo sapiens_hsa009200.29895291
110Fructose and mannose metabolism_Homo sapiens_hsa000510.28742101
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28623890
112Circadian rhythm_Homo sapiens_hsa047100.28294455
113Glutamatergic synapse_Homo sapiens_hsa047240.27598368
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27224467
115Vitamin digestion and absorption_Homo sapiens_hsa049770.26479306
116Linoleic acid metabolism_Homo sapiens_hsa005910.25727938
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25077837
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24800897
119Cocaine addiction_Homo sapiens_hsa050300.24725009
120Circadian entrainment_Homo sapiens_hsa047130.22061329
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20839647
122Calcium signaling pathway_Homo sapiens_hsa040200.20589816
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.20328385
124N-Glycan biosynthesis_Homo sapiens_hsa005100.20003635
125Tyrosine metabolism_Homo sapiens_hsa003500.18135742
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17785419
127Renin secretion_Homo sapiens_hsa049240.17561480
128Wnt signaling pathway_Homo sapiens_hsa043100.16968649
129GnRH signaling pathway_Homo sapiens_hsa049120.16854185
130Cholinergic synapse_Homo sapiens_hsa047250.16642289
131Pyruvate metabolism_Homo sapiens_hsa006200.15582835
132Bladder cancer_Homo sapiens_hsa052190.15215926
133Phenylalanine metabolism_Homo sapiens_hsa003600.14783468
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12274267
135Salivary secretion_Homo sapiens_hsa049700.12195056
136African trypanosomiasis_Homo sapiens_hsa051430.11741630
137Renin-angiotensin system_Homo sapiens_hsa046140.11298996
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09800860
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09533493
140Fatty acid elongation_Homo sapiens_hsa000620.08987396
141Ether lipid metabolism_Homo sapiens_hsa005650.08667358

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