ATR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.79795187
2synaptonemal complex organization (GO:0070193)8.87112815
3synaptonemal complex assembly (GO:0007130)8.59317492
4DNA methylation involved in gamete generation (GO:0043046)8.41254390
5fusion of sperm to egg plasma membrane (GO:0007342)8.13053809
6axonemal dynein complex assembly (GO:0070286)7.46084316
7acrosome assembly (GO:0001675)7.15411796
8sperm-egg recognition (GO:0035036)6.78516387
9male meiosis I (GO:0007141)6.78036444
10chromosome organization involved in meiosis (GO:0070192)6.72587248
11binding of sperm to zona pellucida (GO:0007339)6.56379570
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.35721555
13sperm motility (GO:0030317)6.31819274
14multicellular organism reproduction (GO:0032504)6.27352751
15nuclear pore complex assembly (GO:0051292)6.24229495
16regulation of meiosis I (GO:0060631)6.20980817
17meiotic nuclear division (GO:0007126)6.17668995
18cell-cell recognition (GO:0009988)6.12053071
19spermatid development (GO:0007286)6.09849324
20plasma membrane fusion (GO:0045026)6.05572918
21motile cilium assembly (GO:0044458)6.04776418
22epithelial cilium movement (GO:0003351)5.94131273
23nuclear pore organization (GO:0006999)5.56356146
24cilium movement (GO:0003341)5.54751700
25meiosis I (GO:0007127)5.53565195
26gene silencing by RNA (GO:0031047)5.41217118
27meiotic cell cycle (GO:0051321)5.10169903
28monoubiquitinated protein deubiquitination (GO:0035520)5.07228191
29pore complex assembly (GO:0046931)4.94670076
30reproduction (GO:0000003)4.84297579
31phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.81856798
32mitotic sister chromatid cohesion (GO:0007064)4.52940314
33meiotic cell cycle process (GO:1903046)4.50593662
34regulation of centriole replication (GO:0046599)4.49687550
35acrosome reaction (GO:0007340)4.44821347
36synapsis (GO:0007129)4.42155863
37genitalia morphogenesis (GO:0035112)4.37998107
38cell wall macromolecule catabolic process (GO:0016998)4.33814418
39cell wall macromolecule metabolic process (GO:0044036)4.33814418
40regulation of histone H3-K9 methylation (GO:0051570)4.30660622
41cellular response to ethanol (GO:0071361)4.30110470
42fertilization (GO:0009566)4.22383195
43single fertilization (GO:0007338)4.20754800
44germ cell development (GO:0007281)4.18773911
45hepatocyte apoptotic process (GO:0097284)4.17453903
46negative regulation of DNA repair (GO:0045738)4.16492087
47regulation of protein polyubiquitination (GO:1902914)4.15061938
48DNA alkylation (GO:0006305)4.14208669
49DNA methylation (GO:0006306)4.14208669
50translesion synthesis (GO:0019985)4.04690413
51sister chromatid cohesion (GO:0007062)4.03399734
52cellular process involved in reproduction in multicellular organism (GO:0022412)3.97214974
53centriole replication (GO:0007099)3.93964390
54histone exchange (GO:0043486)3.83302415
55meiotic chromosome segregation (GO:0045132)3.78892005
56spermatogenesis (GO:0007283)3.78142055
57male gamete generation (GO:0048232)3.77777149
58sister chromatid segregation (GO:0000819)3.74395187
59protein localization to cilium (GO:0061512)3.70442768
60regulation of RNA export from nucleus (GO:0046831)3.70368330
61protein localization to chromosome, centromeric region (GO:0071459)3.67577550
62intraciliary transport (GO:0042073)3.67305596
63regulation of cilium movement (GO:0003352)3.65276448
64microtubule depolymerization (GO:0007019)3.64527189
65gene silencing (GO:0016458)3.63243097
66non-recombinational repair (GO:0000726)3.58904390
67double-strand break repair via nonhomologous end joining (GO:0006303)3.58904390
68regulation of sister chromatid cohesion (GO:0007063)3.58090961
69negative regulation of inclusion body assembly (GO:0090084)3.57777922
70seminiferous tubule development (GO:0072520)3.51498744
71iron ion import (GO:0097286)3.50817621
72gamete generation (GO:0007276)3.49850535
73cytoplasmic mRNA processing body assembly (GO:0033962)3.49355071
74peptidyl-lysine trimethylation (GO:0018023)3.48982583
75regulation of histone H3-K27 methylation (GO:0061085)3.48414467
76centriole assembly (GO:0098534)3.47423170
77ventricular system development (GO:0021591)3.43411152
78mitotic sister chromatid segregation (GO:0000070)3.41375517
79DNA duplex unwinding (GO:0032508)3.38840494
80DNA methylation or demethylation (GO:0044728)3.38059822
81protein localization to kinetochore (GO:0034501)3.36521316
82ribosome assembly (GO:0042255)3.35493279
83DNA replication-dependent nucleosome assembly (GO:0006335)3.32271081
84DNA replication-dependent nucleosome organization (GO:0034723)3.32271081
85regulation of centrosome cycle (GO:0046605)3.28830803
86histone-serine phosphorylation (GO:0035404)3.27954732
87DNA geometric change (GO:0032392)3.27440223
88mitotic chromosome condensation (GO:0007076)3.22543503
89histone H3-K9 methylation (GO:0051567)3.21392754
90regulation of establishment of cell polarity (GO:2000114)3.21025279
91DNA synthesis involved in DNA repair (GO:0000731)3.17407169
92lipid translocation (GO:0034204)3.15149213
93phospholipid translocation (GO:0045332)3.15149213
94histone mRNA catabolic process (GO:0071044)3.13027360
95sperm capacitation (GO:0048240)3.11772712
96positive regulation of protein import into nucleus, translocation (GO:0033160)3.11236592
97reciprocal meiotic recombination (GO:0007131)3.11048162
98reciprocal DNA recombination (GO:0035825)3.11048162
99histone H2A acetylation (GO:0043968)3.09569574
100positive regulation of granulocyte differentiation (GO:0030854)3.06980511
101protein K6-linked ubiquitination (GO:0085020)3.05840658
102kinetochore organization (GO:0051383)3.03274936
103protein K48-linked deubiquitination (GO:0071108)3.01794060
104nuclear envelope disassembly (GO:0051081)3.00588275
105membrane disassembly (GO:0030397)3.00588275
106regulation of nucleobase-containing compound transport (GO:0032239)3.00403994
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.99091160
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.99091160
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.99091160
110histone H3-K4 trimethylation (GO:0080182)2.99080921
111V(D)J recombination (GO:0033151)2.98058032
112intra-S DNA damage checkpoint (GO:0031573)2.95961097
113negative regulation of fibroblast apoptotic process (GO:2000270)2.95958420
114DNA topological change (GO:0006265)2.95681936
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94160404
116regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94160404
117regulation of spindle checkpoint (GO:0090231)2.94071930
118regulation of mitotic sister chromatid segregation (GO:0033047)2.93781055
119regulation of sister chromatid segregation (GO:0033045)2.93781055
120regulation of mitotic sister chromatid separation (GO:0010965)2.93781055
121DNA unwinding involved in DNA replication (GO:0006268)2.93225725
122attachment of spindle microtubules to kinetochore (GO:0008608)2.92819785
123resolution of meiotic recombination intermediates (GO:0000712)2.92319335
124chromosome organization (GO:0051276)2.92300641
125protein K11-linked deubiquitination (GO:0035871)2.91513136
126histone H3-K36 demethylation (GO:0070544)2.90786422
127regulation of centrosome duplication (GO:0010824)2.90517357
128DNA packaging (GO:0006323)2.90441879
129positive regulation of chromosome segregation (GO:0051984)2.87944252
130chaperone-mediated protein complex assembly (GO:0051131)2.87931259
131mitotic nuclear envelope disassembly (GO:0007077)2.87534015
132interkinetic nuclear migration (GO:0022027)2.86784124
133chromatin remodeling at centromere (GO:0031055)2.86209680
134nucleus organization (GO:0006997)2.85838185
135oogenesis (GO:0048477)2.84957089
136DNA modification (GO:0006304)2.81477488
137negative regulation of meiosis (GO:0045835)2.81402757
138histone H3-K9 modification (GO:0061647)2.80506797
139positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.79499869
140NLS-bearing protein import into nucleus (GO:0006607)2.78733426
141regulation of establishment or maintenance of cell polarity (GO:0032878)2.78652903
142nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.77545391
143UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74659029
144regulation of fibroblast apoptotic process (GO:2000269)2.72350808
145microtubule anchoring (GO:0034453)2.72007673
146mitotic spindle checkpoint (GO:0071174)2.71407411
147definitive hemopoiesis (GO:0060216)2.70147154
148regulation of DNA endoreduplication (GO:0032875)2.69989761
149spindle checkpoint (GO:0031577)2.68941592
150mitotic spindle assembly checkpoint (GO:0007094)2.66933854
151peptidyl-lysine methylation (GO:0018022)2.65982822
152negative regulation of chromosome segregation (GO:0051985)2.65282937
153regulation of chromosome segregation (GO:0051983)2.65101524
154DNA replication initiation (GO:0006270)2.62972822
155regulation of B cell receptor signaling pathway (GO:0050855)2.62360990
156snRNA transcription (GO:0009301)2.61659654
157spindle assembly checkpoint (GO:0071173)2.61016579
158negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.60033672
159negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.60033672
160negative regulation of mitotic sister chromatid segregation (GO:0033048)2.60033672
161negative regulation of mitotic sister chromatid separation (GO:2000816)2.60033672
162negative regulation of sister chromatid segregation (GO:0033046)2.60033672
163dosage compensation (GO:0007549)2.56526352
164pre-miRNA processing (GO:0031054)2.55362548
165response to X-ray (GO:0010165)2.54820526
166DNA conformation change (GO:0071103)2.54352045
167prenylation (GO:0097354)2.52588133
168protein prenylation (GO:0018342)2.52588133
169protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.52033620
170COPII vesicle coating (GO:0048208)2.50307710
171establishment of protein localization to Golgi (GO:0072600)2.49337190
172metaphase plate congression (GO:0051310)2.49246665
173positive regulation of DNA-templated transcription, initiation (GO:2000144)2.48310023
174regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47931540
175histone H3-K4 methylation (GO:0051568)2.46019599
176pericardium development (GO:0060039)2.44984001
177establishment of chromosome localization (GO:0051303)2.44863173
178cilium or flagellum-dependent cell motility (GO:0001539)12.8442164
179piRNA metabolic process (GO:0034587)11.8190517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.27657642
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.98427043
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.64838194
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53163105
5GATA1_22025678_ChIP-Seq_K562_Human2.94153569
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.92856198
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81520202
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.60521649
9EZH2_22144423_ChIP-Seq_EOC_Human2.59456312
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50628514
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43699473
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.35779884
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.32002762
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28697775
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18767448
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17295455
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09864604
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04180631
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04090131
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2728524
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97143276
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93699286
23AR_21909140_ChIP-Seq_LNCAP_Human1.92775915
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88881447
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.77767836
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74395130
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73526581
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70544219
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63132225
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60045213
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58775912
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57083348
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56602837
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52825437
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51723781
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.45883737
37FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45722004
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43484623
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.40786752
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33772683
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.32993388
42MYB_26560356_Chip-Seq_TH2_Human1.32167629
43* EWS_26573619_Chip-Seq_HEK293_Human1.31800517
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31167954
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31091569
46BRD4_25478319_ChIP-Seq_HGPS_Human1.30767876
47ZNF274_21170338_ChIP-Seq_K562_Hela1.30641080
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.30601343
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25518093
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21704413
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21704413
52TFEB_21752829_ChIP-Seq_HELA_Human1.21307652
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19668915
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.19586701
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18986054
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18972134
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16858594
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.15177946
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14687144
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12249428
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12099688
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11050444
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09264085
64* STAT3_23295773_ChIP-Seq_U87_Human1.09080757
65* FOXP3_21729870_ChIP-Seq_TREG_Human1.08989594
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.08883830
67RUNX_20019798_ChIP-Seq_JUKART_Human1.07222497
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.07184637
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06613043
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05790301
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05238164
72* VDR_23849224_ChIP-Seq_CD4+_Human1.04180850
73TAF15_26573619_Chip-Seq_HEK293_Human1.03078846
74AHR_22903824_ChIP-Seq_MCF-7_Human1.01723253
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01481030
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01360132
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00547853
78IRF8_21731497_ChIP-ChIP_J774_Mouse0.99994296
79OCT4_18555785_Chip-Seq_ESCs_Mouse0.99984852
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99867560
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99348863
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98865578
83MYB_26560356_Chip-Seq_TH1_Human0.98044029
84TP53_16413492_ChIP-PET_HCT116_Human0.97724258
85FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97014576
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96471467
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95748679
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95508791
89SALL4_22934838_ChIP-ChIP_CD34+_Human0.95366794
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95328785
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95302057
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.95230319
93SCL_19346495_ChIP-Seq_HPC-7_Human0.94858977
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94714682
95ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94303522
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93738187
97TP63_23658742_ChIP-Seq_EP156T_Human0.92610324
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92533849
99SMAD4_21799915_ChIP-Seq_A2780_Human0.92206582
100WDR5_24793694_ChIP-Seq_LNCAP_Human0.91664344
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91591297
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.91207252
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91195159
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90846578
105ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90781380
106CDX2_22108803_ChIP-Seq_LS180_Human0.90174252
107STAT3_18555785_Chip-Seq_ESCs_Mouse0.89610678
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89536144
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89536144
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.89334763
111GATA3_26560356_Chip-Seq_TH2_Human0.89081242
112GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88811409
113P300_18555785_Chip-Seq_ESCs_Mouse0.88726603
114KDM5A_27292631_Chip-Seq_BREAST_Human0.87839780
115CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86114445
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85701031
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84859872
118PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83783255
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83535886
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83535886
121OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82432179
122CRX_20693478_ChIP-Seq_RETINA_Mouse0.82293951
123ELK1_19687146_ChIP-ChIP_HELA_Human0.82171671
124FUS_26573619_Chip-Seq_HEK293_Human0.82030572
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.81810866
126P53_22387025_ChIP-Seq_ESCs_Mouse0.81430157
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81304618
128KLF4_18555785_Chip-Seq_ESCs_Mouse0.81214412
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81180261
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80973274
131MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79906395
132DCP1A_22483619_ChIP-Seq_HELA_Human0.79396580
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79164883
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78905292
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78136489
136ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78096050
137RNF2_27304074_Chip-Seq_NSC_Mouse0.77761128
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.77681419
139TCF4_23295773_ChIP-Seq_U87_Human0.76677912
140RUNX1_27457419_Chip-Seq_LIVER_Mouse0.76403281
141ESRRB_18555785_Chip-Seq_ESCs_Mouse0.76295475
142XRN2_22483619_ChIP-Seq_HELA_Human0.75912493
143CMYC_18555785_Chip-Seq_ESCs_Mouse0.74805530
144EST1_17652178_ChIP-ChIP_JURKAT_Human0.73719233
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73046947
146ZFX_18555785_Chip-Seq_ESCs_Mouse0.72102684
147BCAT_22108803_ChIP-Seq_LS180_Human0.71675861
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.71486920
149CBP_20019798_ChIP-Seq_JUKART_Human0.71127079
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.71127079
151STAT1_17558387_ChIP-Seq_HELA_Human0.69849186
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.69682652
153ER_23166858_ChIP-Seq_MCF-7_Human0.69623100
154MYB_21317192_ChIP-Seq_ERMYB_Mouse0.69540390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.76824839
2MP0008877_abnormal_DNA_methylation7.55342292
3* MP0001929_abnormal_gametogenesis4.31587995
4MP0003698_abnormal_male_reproductive4.15276372
5* MP0002210_abnormal_sex_determination3.84287951
6* MP0010094_abnormal_chromosome_stability3.51594446
7MP0008058_abnormal_DNA_repair3.42901234
8* MP0001145_abnormal_male_reproductive3.23772254
9MP0002877_abnormal_melanocyte_morpholog2.95895348
10* MP0000653_abnormal_sex_gland2.81400511
11MP0003111_abnormal_nucleus_morphology2.78105889
12MP0010234_abnormal_vibrissa_follicle2.43465624
13MP0002009_preneoplasia2.40584233
14MP0008995_early_reproductive_senescence2.38636599
15* MP0003077_abnormal_cell_cycle2.38331578
16MP0000569_abnormal_digit_pigmentation2.35719701
17* MP0008057_abnormal_DNA_replication2.32939823
18MP0002161_abnormal_fertility/fecundity2.24200021
19MP0010307_abnormal_tumor_latency2.21987398
20MP0003693_abnormal_embryo_hatching2.18218723
21MP0003300_gastrointestinal_ulcer2.11148032
22MP0002160_abnormal_reproductive_system1.90453034
23MP0002653_abnormal_ependyma_morphology1.89273908
24MP0010678_abnormal_skin_adnexa1.81416743
25MP0000537_abnormal_urethra_morphology1.81120360
26MP0004957_abnormal_blastocyst_morpholog1.71432790
27* MP0003786_premature_aging1.65140952
28MP0005623_abnormal_meninges_morphology1.58070038
29MP0010352_gastrointestinal_tract_polyps1.56632631
30* MP0008007_abnormal_cellular_replicative1.52775768
31MP0003941_abnormal_skin_development1.51908735
32MP0002396_abnormal_hematopoietic_system1.50082464
33MP0003950_abnormal_plasma_membrane1.48031796
34MP0005647_abnormal_sex_gland1.45209720
35MP0005408_hypopigmentation1.43936018
36* MP0004808_abnormal_hematopoietic_stem1.35630959
37MP0001730_embryonic_growth_arrest1.31703513
38MP0003091_abnormal_cell_migration1.30658552
39MP0004233_abnormal_muscle_weight1.27054004
40MP0003656_abnormal_erythrocyte_physiolo1.24372959
41MP0002166_altered_tumor_susceptibility1.23135950
42MP0005389_reproductive_system_phenotype1.22044593
43MP0001545_abnormal_hematopoietic_system1.21578815
44MP0005397_hematopoietic_system_phenotyp1.21578815
45MP0003868_abnormal_feces_composition1.19539969
46MP0008932_abnormal_embryonic_tissue1.19255729
47MP0005076_abnormal_cell_differentiation1.16876942
48MP0003191_abnormal_cellular_cholesterol1.13510129
49MP0005451_abnormal_body_composition1.13320151
50MP0000350_abnormal_cell_proliferation1.13095395
51* MP0005621_abnormal_cell_physiology1.11669177
52MP0003787_abnormal_imprinting1.11632866
53MP0001293_anophthalmia1.11346361
54MP0009697_abnormal_copulation1.06997777
55* MP0000427_abnormal_hair_cycle1.06885859
56MP0004381_abnormal_hair_follicle1.05315173
57MP0005310_abnormal_salivary_gland1.04845017
58MP0004264_abnormal_extraembryonic_tissu1.03686220
59MP0002084_abnormal_developmental_patter1.03581571
60MP0004197_abnormal_fetal_growth/weight/1.02591292
61MP0003890_abnormal_embryonic-extraembry1.02166015
62MP0003121_genomic_imprinting1.01611558
63MP0005275_abnormal_skin_tensile1.01569782
64MP0002006_tumorigenesis1.01468830
65* MP0000313_abnormal_cell_death1.01362335
66MP0001672_abnormal_embryogenesis/_devel1.01185639
67MP0005380_embryogenesis_phenotype1.01185639
68MP0001873_stomach_inflammation0.99627224
69MP0003566_abnormal_cell_adhesion0.99332918
70MP0003878_abnormal_ear_physiology0.99196268
71MP0005377_hearing/vestibular/ear_phenot0.99196268
72MP0002060_abnormal_skin_morphology0.99082078
73MP0009278_abnormal_bone_marrow0.97667388
74* MP0001119_abnormal_female_reproductive0.96593472
75MP0002282_abnormal_trachea_morphology0.95459387
76MP0003123_paternal_imprinting0.94934635
77MP0005075_abnormal_melanosome_morpholog0.94205240
78MP0001661_extended_life_span0.94133036
79MP0008438_abnormal_cutaneous_collagen0.90329486
80MP0001697_abnormal_embryo_size0.88959055
81MP0003984_embryonic_growth_retardation0.87432773
82MP0002085_abnormal_embryonic_tissue0.86289081
83MP0002088_abnormal_embryonic_growth/wei0.85006193
84MP0002452_abnormal_antigen_presenting0.84306813
85* MP0001191_abnormal_skin_condition0.83663288
86MP0001790_abnormal_immune_system0.83362071
87MP0005387_immune_system_phenotype0.83362071
88MP0005174_abnormal_tail_pigmentation0.82024585
89MP0000490_abnormal_crypts_of0.80836216
90MP0002086_abnormal_extraembryonic_tissu0.80695623
91MP0002168_other_aberrant_phenotype0.80434251
92* MP0000703_abnormal_thymus_morphology0.78499042
93MP0003221_abnormal_cardiomyocyte_apopto0.78435677
94MP0000627_abnormal_mammary_gland0.78309922
95MP0006054_spinal_hemorrhage0.77439840
96MP0003448_altered_tumor_morphology0.76588151
97MP0005248_abnormal_Harderian_gland0.76512026
98* MP0002019_abnormal_tumor_incidence0.76311559
99MP0003453_abnormal_keratinocyte_physiol0.75490852
100MP0002420_abnormal_adaptive_immunity0.74971121
101MP0003699_abnormal_female_reproductive0.74873804
102* MP0001216_abnormal_epidermal_layer0.74753668
103* MP0002080_prenatal_lethality0.74695322
104MP0001835_abnormal_antigen_presentation0.74640891
105MP0003705_abnormal_hypodermis_morpholog0.73295532
106MP0001819_abnormal_immune_cell0.73242418
107MP0009703_decreased_birth_body0.72666188
108MP0002092_abnormal_eye_morphology0.71246445
109MP0001853_heart_inflammation0.70997492
110MP0001186_pigmentation_phenotype0.70453741
111MP0003183_abnormal_peptide_metabolism0.69655380
112MP0002723_abnormal_immune_serum0.69001875
113MP0004947_skin_inflammation0.68706104
114* MP0002398_abnormal_bone_marrow0.66912174
115* MP0003763_abnormal_thymus_physiology0.66894750
116MP0009672_abnormal_birth_weight0.66510009
117MP0000383_abnormal_hair_follicle0.66121048
118MP0005000_abnormal_immune_tolerance0.65387767
119MP0003936_abnormal_reproductive_system0.65029022
120MP0008961_abnormal_basal_metabolism0.64958117
121MP0002928_abnormal_bile_duct0.64804213
122MP0000015_abnormal_ear_pigmentation0.62837233
123MP0004133_heterotaxia0.61706275
124MP0002102_abnormal_ear_morphology0.59781063
125MP0003943_abnormal_hepatobiliary_system0.57808931
126MP0003115_abnormal_respiratory_system0.55752460
127MP0005391_vision/eye_phenotype0.54861596
128MP0003937_abnormal_limbs/digits/tail_de0.54103355
129MP0000358_abnormal_cell_content/0.52799139
130* MP0000432_abnormal_head_morphology0.52027630
131MP0002405_respiratory_system_inflammati0.51753682
132MP0000685_abnormal_immune_system0.49840318
133MP0002697_abnormal_eye_size0.49161844
134MP0000371_diluted_coat_color0.48633068
135MP0002095_abnormal_skin_pigmentation0.48439872
136MP0001915_intracranial_hemorrhage0.46083830
137* MP0000689_abnormal_spleen_morphology0.45427444
138MP0003567_abnormal_fetal_cardiomyocyte0.43816009
139* MP0002722_abnormal_immune_system0.42999033
140MP0002075_abnormal_coat/hair_pigmentati0.42651914
141MP0002254_reproductive_system_inflammat0.42378968
142MP0005384_cellular_phenotype0.41881605
143* MP0000716_abnormal_immune_system0.41668120
144MP0001800_abnormal_humoral_immune0.40853828
145* MP0002429_abnormal_blood_cell0.39918413

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)8.94372704
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.94372704
3Abnormal respiratory motile cilium physiology (HP:0012261)7.47313986
4Rhinitis (HP:0012384)6.39531006
5Abnormal respiratory motile cilium morphology (HP:0005938)6.37838538
6Abnormal respiratory epithelium morphology (HP:0012253)6.37838538
7Abnormal ciliary motility (HP:0012262)6.18319151
8Chronic bronchitis (HP:0004469)5.61143847
9Nasal polyposis (HP:0100582)4.95118390
10Abnormality of the lower motor neuron (HP:0002366)4.80069863
11Gonadotropin excess (HP:0000837)4.59153081
12Nephronophthisis (HP:0000090)4.40106358
13Infertility (HP:0000789)4.35557868
14Subacute progressive viral hepatitis (HP:0006572)4.08891769
15Bronchiectasis (HP:0002110)4.07862750
16Abnormality of the nasal mucosa (HP:0000433)3.90646144
17Amyotrophic lateral sclerosis (HP:0007354)3.72794565
18Bronchitis (HP:0012387)3.61860178
19T lymphocytopenia (HP:0005403)3.59930988
20Abnormality of the renal medulla (HP:0100957)3.52114850
21Upper motor neuron abnormality (HP:0002127)3.38172502
22Degeneration of anterior horn cells (HP:0002398)3.34770269
23Abnormality of the anterior horn cell (HP:0006802)3.34770269
24Deep philtrum (HP:0002002)3.34420090
25Abnormal spermatogenesis (HP:0008669)3.28712794
26Chromsome breakage (HP:0040012)3.28392736
27Tubulointerstitial nephritis (HP:0001970)3.24934602
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23739111
29Abnormality of T cell number (HP:0011839)3.16847016
30Osteolytic defects of the hand bones (HP:0009699)3.16028106
31Osteolytic defects of the phalanges of the hand (HP:0009771)3.16028106
32Azoospermia (HP:0000027)3.14930810
33Absent frontal sinuses (HP:0002688)3.13660662
34Supernumerary spleens (HP:0009799)3.04347984
35Impaired proprioception (HP:0010831)2.98663825
36Fair hair (HP:0002286)2.92711976
37Recurrent sinusitis (HP:0011108)2.91903272
38Median cleft lip (HP:0000161)2.80032683
39Ankyloglossia (HP:0010296)2.79564717
40Viral hepatitis (HP:0006562)2.79253618
41Thyroiditis (HP:0100646)2.76314474
42Abnormality of chromosome stability (HP:0003220)2.73715403
43Hypoplasia of the thymus (HP:0000778)2.73025535
44Recurrent otitis media (HP:0000403)2.69684197
45Periodontitis (HP:0000704)2.69046508
46Curly hair (HP:0002212)2.68209847
47* Sandal gap (HP:0001852)2.68125032
48Postaxial foot polydactyly (HP:0001830)2.64340897
49Autoimmune hemolytic anemia (HP:0001890)2.62758195
50B lymphocytopenia (HP:0010976)2.61889857
51Syringomyelia (HP:0003396)2.60859241
52Spinal cord lesions (HP:0100561)2.60859241
53Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.60194038
54* Prominent nose (HP:0000448)2.59829719
55Ectopic kidney (HP:0000086)2.58670777
56Molar tooth sign on MRI (HP:0002419)2.58663036
57Abnormality of midbrain morphology (HP:0002418)2.58663036
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.55775736
59Rhabdomyosarcoma (HP:0002859)2.52415780
60Abnormality of oral frenula (HP:0000190)2.52324382
61Abnormality of B cell number (HP:0010975)2.50538275
62Sparse lateral eyebrow (HP:0005338)2.46803371
63IgA deficiency (HP:0002720)2.46660474
64Impulsivity (HP:0100710)2.45448608
65Facial cleft (HP:0002006)2.44163727
66Conjunctival telangiectasia (HP:0000524)2.44138309
67Abnormality of the astrocytes (HP:0100707)2.42123713
68Astrocytoma (HP:0009592)2.42123713
69* Fibular hypoplasia (HP:0003038)2.41062206
70Termporal pattern (HP:0011008)2.39050361
71Insidious onset (HP:0003587)2.39050361
72Relative macrocephaly (HP:0004482)2.38623022
73Volvulus (HP:0002580)2.38245493
74Tubular atrophy (HP:0000092)2.36352046
75Abnormal foot bone ossification (HP:0010675)2.35392264
76Abnormality of the renal cortex (HP:0011035)2.33929400
77Recurrent viral infections (HP:0004429)2.33900873
78Glioma (HP:0009733)2.32544996
79Short ribs (HP:0000773)2.31626689
80Abnormality of the preputium (HP:0100587)2.30780630
81Recurrent bronchitis (HP:0002837)2.29004399
82Meckel diverticulum (HP:0002245)2.26109483
83Transitional cell carcinoma of the bladder (HP:0006740)2.26007299
84Tubulointerstitial abnormality (HP:0001969)2.25217769
85Generalized hypopigmentation of hair (HP:0011358)2.24004448
86Congenital hepatic fibrosis (HP:0002612)2.23996578
87Micronodular cirrhosis (HP:0001413)2.22578660
88Bladder neoplasm (HP:0009725)2.21260599
89Bladder carcinoma (HP:0002862)2.21260599
90Cafe-au-lait spot (HP:0000957)2.18928812
91Thyroid carcinoma (HP:0002890)2.17809697
92Renal dysplasia (HP:0000110)2.16540507
93Abnormality of the ileum (HP:0001549)2.13289587
94Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13123336
95Short chin (HP:0000331)2.11982825
96Medulloblastoma (HP:0002885)2.11773652
97Nephroblastoma (Wilms tumor) (HP:0002667)2.10433537
98Medial flaring of the eyebrow (HP:0010747)2.10010580
99Large earlobe (HP:0009748)2.09842138
100Dysmetric saccades (HP:0000641)2.09841625
101Heterotopia (HP:0002282)2.09754933
102Colitis (HP:0002583)2.07335237
103IgM deficiency (HP:0002850)2.06499816
104Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.04907437
105Abnormality of the frontal sinuses (HP:0002687)2.03880590
106Overgrowth (HP:0001548)2.00980336
107Spondylolisthesis (HP:0003302)2.00352395
108Clubbing of toes (HP:0100760)2.00044279
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6997466
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98787265
111Acute lymphatic leukemia (HP:0006721)1.97410167
112Low anterior hairline (HP:0000294)1.97324765
113Oculomotor apraxia (HP:0000657)1.95322645
114Chronic sinusitis (HP:0011109)1.93453621
115Biliary tract neoplasm (HP:0100574)1.93208870
116Glucose intolerance (HP:0000833)1.93103182
117Severe combined immunodeficiency (HP:0004430)1.92931418
118Embryonal renal neoplasm (HP:0011794)1.92501327
119Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92048631
120Basal cell carcinoma (HP:0002671)1.91644049
121Abnormality of chromosome segregation (HP:0002916)1.91283618
122Stage 5 chronic kidney disease (HP:0003774)1.90742194
123* Sloping forehead (HP:0000340)1.89816622
124Horizontal nystagmus (HP:0000666)1.89690149
125Combined immunodeficiency (HP:0005387)1.89166233
126Ependymoma (HP:0002888)1.88468963
127Cystic hygroma (HP:0000476)1.86971900
128Pancreatic fibrosis (HP:0100732)1.86740880
129Duodenal stenosis (HP:0100867)1.83458388
130Small intestinal stenosis (HP:0012848)1.83458388
131Short thorax (HP:0010306)1.83066510
132Abnormal glucose tolerance (HP:0001952)1.82854543
133Abnormality of the carotid arteries (HP:0005344)1.82322090
134Overlapping toe (HP:0001845)1.81390775
135Duplicated collecting system (HP:0000081)1.80120542
136Myelodysplasia (HP:0002863)1.79633760
137Narrow palate (HP:0000189)1.79064651
138Leiomyosarcoma (HP:0100243)1.78628527
139Uterine leiomyosarcoma (HP:0002891)1.78628527
140Neoplasm of the small intestine (HP:0100833)1.78574952
141Truncal obesity (HP:0001956)1.76757366
142Neoplasm of striated muscle (HP:0009728)1.76107741
143Delayed closure of the anterior fontanelle (HP:0001476)1.75251815
144Male infertility (HP:0003251)1.73658044
145Coarse hair (HP:0002208)1.73439977
146Cystic liver disease (HP:0006706)1.73253483
147Chronic diarrhea (HP:0002028)1.73248253
148Absent epiphyses (HP:0010577)1.72959511
149Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72959511
150Acute myeloid leukemia (HP:0004808)1.72446126
151Postaxial hand polydactyly (HP:0001162)1.71486103
152Macroorchidism (HP:0000053)1.70866442
153Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69805002
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.69610317
155Panhypogammaglobulinemia (HP:0003139)1.68908880
156Microglossia (HP:0000171)1.68209002
157Abnormality of ocular smooth pursuit (HP:0000617)1.67704375
158Malignant gastrointestinal tract tumors (HP:0006749)1.67529084
159Gastrointestinal carcinoma (HP:0002672)1.67529084
160Bell-shaped thorax (HP:0001591)1.67119789
161Cutaneous melanoma (HP:0012056)1.66856831
162Freckling (HP:0001480)1.66726026
163Prostate neoplasm (HP:0100787)1.66314768
164Acute hepatic failure (HP:0006554)1.66295841
165Abnormality of the renal collecting system (HP:0004742)1.64275169
166Abnormality of DNA repair (HP:0003254)1.64249666
167Atrophy/Degeneration involving motor neurons (HP:0007373)1.64032396
168True hermaphroditism (HP:0010459)1.62798913
169Papillary thyroid carcinoma (HP:0002895)1.60321491
170Abnormal biliary tract physiology (HP:0012439)1.59533855
171Bile duct proliferation (HP:0001408)1.59533855
172High pitched voice (HP:0001620)1.58548218
173Chronic hepatic failure (HP:0100626)1.56728282
174Abnormality of the fingertips (HP:0001211)1.49823841
175* Aplasia/Hypoplasia of the fibula (HP:0006492)1.47872553
176Preaxial hand polydactyly (HP:0001177)1.47069530
177Increased nuchal translucency (HP:0010880)1.46063401
178Taurodontia (HP:0000679)1.44795912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.10180444
2PDK48.10180444
3PDK25.12901200
4CDC73.38883241
5EIF2AK33.34226804
6PNCK3.17748976
7NEK22.69476133
8CDK122.62069796
9BMPR22.29798477
10WEE12.21508050
11AKT32.16760531
12MST42.15531648
13MST1R1.98959024
14MAP3K21.84551354
15TRPM71.76103943
16PBK1.72003548
17TTK1.70262025
18PASK1.67121976
19PLK41.66374027
20* ATR1.62892717
21MELK1.61440914
22PTK2B1.55585932
23STK31.52695181
24SRPK11.52158434
25JAK11.50587598
26NEK61.45576339
27PRKD31.39711512
28TESK11.32842635
29MET1.27632852
30MAP3K101.26857766
31CHEK11.24976642
32ICK1.16551787
33ATM1.11402801
34WNK41.11175515
35NLK1.09726292
36STK391.07252248
37DYRK31.07214804
38ZAK1.07016583
39TYK21.06450608
40BLK1.04594025
41PLK11.04276761
42CAMK1G1.01438150
43EEF2K1.01281175
44BRD40.99725883
45SGK20.95823422
46CHEK20.95600539
47CAMKK20.94076929
48WNK10.90719786
49ACVR1B0.88188488
50MAP3K120.85969500
51BTK0.84755133
52CDK70.84505410
53PIK3CG0.82213608
54SGK30.80177110
55STK40.78599990
56AURKB0.76347871
57NEK10.75189280
58STK100.73712897
59EIF2AK20.72650572
60TRIM280.71485926
61MKNK10.69087602
62CDK40.67149422
63FER0.67132598
64CDK90.67076991
65CCNB10.66124158
66YES10.65215717
67TGFBR20.64854159
68CLK10.64735517
69STK240.63284817
70BUB10.62589087
71MKNK20.62298110
72BMPR1B0.61222030
73MAP3K130.60524934
74TAF10.59720894
75PDGFRA0.59598740
76MAPK110.59099501
77WNK30.56017054
78FGFR10.55852454
79RAF10.55354203
80PIM10.55298467
81LATS10.54590846
82OXSR10.54150356
83MTOR0.53486031
84KSR10.53207270
85CDK20.53014780
86FGFR40.51882376
87IKBKE0.51753146
88BRSK20.51104809
89RPS6KB10.50097893
90PLK30.49690094
91CDK10.48611814
92VRK10.47646522
93CHUK0.47266869
94EGFR0.45821229
95ITK0.44499755
96CSNK1D0.44438460
97CAMK1D0.44292099
98PRKDC0.43001141
99PRKAA20.42882048
100MAP4K10.41195270
101MAPK150.40435908
102CDK60.39880406
103TEC0.39679868
104PTK60.37645864
105FRK0.37577220
106MARK30.36787901
107SCYL20.36431786
108JAK30.35543453
109KIT0.35069387
110CSF1R0.33960264
111RPS6KB20.33423485
112PDK10.33197379
113TYRO30.33074979
114MAP3K40.32786069
115TGFBR10.32687626
116RPS6KA50.30443847
117MAP3K140.27930361
118MAP3K80.26487940
119MAPK140.26426927
120CSNK2A20.26138234
121IRAK10.24917151
122STK38L0.24450629
123EIF2AK10.24366479
124FGFR30.24216014
125CSNK2A10.23765521
126AKT10.23234382
127MAP2K70.22094710
128DYRK1B0.21795048
129ERBB30.21593308
130MAPK10.20910816
131CDK30.20387210
132RPS6KA40.20082184
133GSK3B0.19346294
134NUAK10.18602700
135PDGFRB0.18592807
136TLK10.16789321
137TSSK60.15917135
138NEK90.15349858
139MAPK100.15269320
140TXK0.14843572
141FLT30.14780916

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fanconi anemia pathway_Homo sapiens_hsa034603.80299575
2Homologous recombination_Homo sapiens_hsa034403.44120983
3Non-homologous end-joining_Homo sapiens_hsa034503.27957810
4DNA replication_Homo sapiens_hsa030303.02036267
5RNA transport_Homo sapiens_hsa030133.01645199
6Basal transcription factors_Homo sapiens_hsa030223.01182593
7Mismatch repair_Homo sapiens_hsa034302.98812716
8Selenocompound metabolism_Homo sapiens_hsa004502.94489132
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70690410
10mRNA surveillance pathway_Homo sapiens_hsa030152.44554300
11Spliceosome_Homo sapiens_hsa030402.41334586
12Base excision repair_Homo sapiens_hsa034102.37871169
13Dorso-ventral axis formation_Homo sapiens_hsa043202.37352481
14Vitamin B6 metabolism_Homo sapiens_hsa007502.32184239
15* Cell cycle_Homo sapiens_hsa041102.30140313
16Systemic lupus erythematosus_Homo sapiens_hsa053222.18654893
17Nucleotide excision repair_Homo sapiens_hsa034202.07171954
18Non-small cell lung cancer_Homo sapiens_hsa052232.00612505
19RNA degradation_Homo sapiens_hsa030181.99784375
20Antigen processing and presentation_Homo sapiens_hsa046121.82498460
21Pyruvate metabolism_Homo sapiens_hsa006201.78918668
22Pentose phosphate pathway_Homo sapiens_hsa000301.73153656
23Pancreatic cancer_Homo sapiens_hsa052121.72558172
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62318518
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59668001
26One carbon pool by folate_Homo sapiens_hsa006701.55817631
27Oocyte meiosis_Homo sapiens_hsa041141.54584535
28Thyroid cancer_Homo sapiens_hsa052161.53871796
29Viral carcinogenesis_Homo sapiens_hsa052031.45500466
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44042277
31Endometrial cancer_Homo sapiens_hsa052131.37828439
32Glucagon signaling pathway_Homo sapiens_hsa049221.34764396
33mTOR signaling pathway_Homo sapiens_hsa041501.31964221
34Herpes simplex infection_Homo sapiens_hsa051681.30538260
35Renal cell carcinoma_Homo sapiens_hsa052111.30114671
36Pyrimidine metabolism_Homo sapiens_hsa002401.26764507
37Prolactin signaling pathway_Homo sapiens_hsa049171.23022028
38Propanoate metabolism_Homo sapiens_hsa006401.22082509
39Glioma_Homo sapiens_hsa052141.15021388
40Epstein-Barr virus infection_Homo sapiens_hsa051691.12222489
41RNA polymerase_Homo sapiens_hsa030201.05319717
42FoxO signaling pathway_Homo sapiens_hsa040681.04223245
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01921464
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01856063
45Purine metabolism_Homo sapiens_hsa002300.99997623
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.99911440
47Proteoglycans in cancer_Homo sapiens_hsa052050.99049777
48Lysine degradation_Homo sapiens_hsa003100.98551383
49Leishmaniasis_Homo sapiens_hsa051400.96761331
50Measles_Homo sapiens_hsa051620.95808907
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95061454
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94133035
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92576821
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.90417911
55Influenza A_Homo sapiens_hsa051640.90245789
56Alcoholism_Homo sapiens_hsa050340.89867747
57* p53 signaling pathway_Homo sapiens_hsa041150.88740548
58Small cell lung cancer_Homo sapiens_hsa052220.86572313
59Hepatitis C_Homo sapiens_hsa051600.86033937
60* HTLV-I infection_Homo sapiens_hsa051660.85268662
61Legionellosis_Homo sapiens_hsa051340.83714440
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82175911
63Melanoma_Homo sapiens_hsa052180.82115948
64Asthma_Homo sapiens_hsa053100.80085984
65Platelet activation_Homo sapiens_hsa046110.78983826
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78848646
67ABC transporters_Homo sapiens_hsa020100.78221113
68Staphylococcus aureus infection_Homo sapiens_hsa051500.75042591
69B cell receptor signaling pathway_Homo sapiens_hsa046620.70078057
70Fatty acid biosynthesis_Homo sapiens_hsa000610.67878321
71N-Glycan biosynthesis_Homo sapiens_hsa005100.67377064
72ErbB signaling pathway_Homo sapiens_hsa040120.66143651
73Toxoplasmosis_Homo sapiens_hsa051450.64874930
74Focal adhesion_Homo sapiens_hsa045100.63410015
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62865670
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.60669070
77Choline metabolism in cancer_Homo sapiens_hsa052310.59351438
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58153377
79Insulin resistance_Homo sapiens_hsa049310.56425562
80Type I diabetes mellitus_Homo sapiens_hsa049400.56355456
81MicroRNAs in cancer_Homo sapiens_hsa052060.56230343
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55330585
83Tuberculosis_Homo sapiens_hsa051520.53097193
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52382267
85T cell receptor signaling pathway_Homo sapiens_hsa046600.51300719
86Glycerolipid metabolism_Homo sapiens_hsa005610.50884461
87Circadian rhythm_Homo sapiens_hsa047100.47426599
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46663679
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.46570501
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.46256602
91Primary immunodeficiency_Homo sapiens_hsa053400.45535820
92Proteasome_Homo sapiens_hsa030500.44831997
93Linoleic acid metabolism_Homo sapiens_hsa005910.44279289
94Prostate cancer_Homo sapiens_hsa052150.41283531
95Huntingtons disease_Homo sapiens_hsa050160.38682468
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.38603046
97Hepatitis B_Homo sapiens_hsa051610.38121483
98Acute myeloid leukemia_Homo sapiens_hsa052210.38021665
99Inositol phosphate metabolism_Homo sapiens_hsa005620.37139492
100TGF-beta signaling pathway_Homo sapiens_hsa043500.36979663
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35443990
102Wnt signaling pathway_Homo sapiens_hsa043100.34943067
103Basal cell carcinoma_Homo sapiens_hsa052170.34588873
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34062808
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32678893
106Osteoclast differentiation_Homo sapiens_hsa043800.31349245
107Colorectal cancer_Homo sapiens_hsa052100.30480013
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.29313381
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29215213
110Hematopoietic cell lineage_Homo sapiens_hsa046400.28200712
111Allograft rejection_Homo sapiens_hsa053300.27186755
112Viral myocarditis_Homo sapiens_hsa054160.26663469
113Apoptosis_Homo sapiens_hsa042100.26263762
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26073911
115Pathways in cancer_Homo sapiens_hsa052000.26013354
116Notch signaling pathway_Homo sapiens_hsa043300.25093951
117Graft-versus-host disease_Homo sapiens_hsa053320.24565573
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23732607
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23411287
120Chronic myeloid leukemia_Homo sapiens_hsa052200.23283381
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22336956
122TNF signaling pathway_Homo sapiens_hsa046680.22207618
123Sphingolipid metabolism_Homo sapiens_hsa006000.22158974
124Salmonella infection_Homo sapiens_hsa051320.20807484
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18433505
126HIF-1 signaling pathway_Homo sapiens_hsa040660.18254339
127Autoimmune thyroid disease_Homo sapiens_hsa053200.17821753
128Biosynthesis of amino acids_Homo sapiens_hsa012300.17439587
129Adherens junction_Homo sapiens_hsa045200.17260404

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