ATRAID

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.42696607
2axon ensheathment in central nervous system (GO:0032291)5.42696607
3proteasome assembly (GO:0043248)4.85212954
4respiratory chain complex IV assembly (GO:0008535)4.59921884
5regulation of mitochondrial translation (GO:0070129)4.57166157
6L-phenylalanine catabolic process (GO:0006559)4.53247827
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.53247827
8fatty acid elongation (GO:0030497)4.51253784
9regulation of cellular amino acid metabolic process (GO:0006521)4.41989075
10cytochrome complex assembly (GO:0017004)4.41621528
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.39698748
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.36103726
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.23640195
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.15020323
15negative regulation of ligase activity (GO:0051352)4.03344722
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.03344722
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.00076086
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.98392773
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.96730153
20L-phenylalanine metabolic process (GO:0006558)3.96730153
21oxidative phosphorylation (GO:0006119)3.96338016
22protein maturation by protein folding (GO:0022417)3.95563594
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.87375887
24signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.87375887
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.85951567
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.85951567
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.85951567
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.73006355
29cullin deneddylation (GO:0010388)3.71636081
30signal transduction involved in DNA integrity checkpoint (GO:0072401)3.67839450
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.67839450
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66099032
33protein neddylation (GO:0045116)3.63469972
34respiratory electron transport chain (GO:0022904)3.59232793
35signal transduction involved in cell cycle checkpoint (GO:0072395)3.58966447
36protein deneddylation (GO:0000338)3.58284515
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58256032
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.54497063
39deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.54273316
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.53971152
41electron transport chain (GO:0022900)3.51013974
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49137890
43ATP synthesis coupled proton transport (GO:0015986)3.49137890
44nucleotide transmembrane transport (GO:1901679)3.45295678
45positive regulation of ligase activity (GO:0051351)3.40951460
46rRNA modification (GO:0000154)3.39870804
47very long-chain fatty acid metabolic process (GO:0000038)3.39371268
48antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.29950909
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.25882075
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.25882075
51purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.25370035
52purine nucleotide salvage (GO:0032261)3.23080591
53platelet dense granule organization (GO:0060155)3.22463736
54peptidyl-histidine modification (GO:0018202)3.20637955
55iron-sulfur cluster assembly (GO:0016226)3.16983308
56metallo-sulfur cluster assembly (GO:0031163)3.16983308
57regulation of cellular amine metabolic process (GO:0033238)3.16674957
58aromatic amino acid family catabolic process (GO:0009074)3.14704963
59protein targeting to mitochondrion (GO:0006626)3.14404673
60signal peptide processing (GO:0006465)3.12797039
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10578592
62C-terminal protein lipidation (GO:0006501)3.09824475
63deoxyribonucleotide catabolic process (GO:0009264)3.04535346
64regulation of ubiquitin-protein transferase activity (GO:0051438)3.04281590
65purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01941815
66positive regulation of cell cycle arrest (GO:0071158)3.01859369
67hydrogen ion transmembrane transport (GO:1902600)3.01244437
68ribosomal small subunit assembly (GO:0000028)3.00036086
69ATP biosynthetic process (GO:0006754)2.99845522
70DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.96245935
71establishment of integrated proviral latency (GO:0075713)2.95832980
72regulation of ligase activity (GO:0051340)2.95530710
73base-excision repair, AP site formation (GO:0006285)2.94650607
74cholesterol biosynthetic process (GO:0006695)2.92614350
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.92540882
76response to dietary excess (GO:0002021)2.92372101
77deoxyribose phosphate catabolic process (GO:0046386)2.92043844
78xenobiotic catabolic process (GO:0042178)2.91727982
79GMP metabolic process (GO:0046037)2.91519940
80establishment of protein localization to mitochondrion (GO:0072655)2.90914279
81DNA deamination (GO:0045006)2.87419630
82mitochondrial DNA replication (GO:0006264)2.87250846
83aerobic respiration (GO:0009060)2.86564728
84short-chain fatty acid metabolic process (GO:0046459)2.84794227
85long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.84469054
86oligodendrocyte differentiation (GO:0048709)2.84216712
87pteridine-containing compound biosynthetic process (GO:0042559)2.83441704
88response to redox state (GO:0051775)2.83373997
89inner mitochondrial membrane organization (GO:0007007)2.82733812
90proton transport (GO:0015992)2.82462953
91protein complex biogenesis (GO:0070271)2.82438461
92response to methylmercury (GO:0051597)2.82346368
93presynaptic membrane assembly (GO:0097105)2.81060660
94antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.79277543
95tricarboxylic acid cycle (GO:0006099)2.78779477
96dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.78338838
97mannosylation (GO:0097502)2.78216704
98aldehyde catabolic process (GO:0046185)2.77083395
99protein localization to mitochondrion (GO:0070585)2.75753909
100deoxyribonucleotide metabolic process (GO:0009262)2.75508052
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74682701
102purine-containing compound salvage (GO:0043101)2.73802865
103translation (GO:0006412)2.73148823
104nucleotide transport (GO:0006862)2.73147295
105myelination (GO:0042552)2.72748788
106establishment of viral latency (GO:0019043)2.72746079
107deoxyribose phosphate metabolic process (GO:0019692)2.72618573
108fatty-acyl-CoA biosynthetic process (GO:0046949)2.72300652
109mitochondrial respiratory chain complex I assembly (GO:0032981)2.72296924
110NADH dehydrogenase complex assembly (GO:0010257)2.72296924
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72296924
112positive regulation of cellular amine metabolic process (GO:0033240)2.72293443
113termination of RNA polymerase III transcription (GO:0006386)2.72053877
114transcription elongation from RNA polymerase III promoter (GO:0006385)2.72053877
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71291000
116branched-chain amino acid catabolic process (GO:0009083)2.70728354
117fatty-acyl-CoA metabolic process (GO:0035337)2.69574199
118axon ensheathment (GO:0008366)2.68448333
119ensheathment of neurons (GO:0007272)2.68448333
120bile acid biosynthetic process (GO:0006699)2.67782166
121cellular ketone body metabolic process (GO:0046950)2.67152247
122chaperone-mediated protein transport (GO:0072321)2.60564745
123presynaptic membrane organization (GO:0097090)2.59731161
124acyl-CoA biosynthetic process (GO:0071616)2.59395675
125thioester biosynthetic process (GO:0035384)2.59395675
126alpha-linolenic acid metabolic process (GO:0036109)2.57388449
127opsonization (GO:0008228)2.56746375
128peroxisome fission (GO:0016559)2.56083217
129glutathione biosynthetic process (GO:0006750)2.55692398
130sterol biosynthetic process (GO:0016126)2.53853274
131amyloid precursor protein catabolic process (GO:0042987)2.53261444
132long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.53084037
133low-density lipoprotein particle remodeling (GO:0034374)2.51535483
134coenzyme catabolic process (GO:0009109)2.51024808
135pyrimidine-containing compound transmembrane transport (GO:0072531)2.50910204
136amyloid precursor protein metabolic process (GO:0042982)2.50675857
137nonribosomal peptide biosynthetic process (GO:0019184)2.48862637
138cysteine metabolic process (GO:0006534)2.47817665
139cofactor catabolic process (GO:0051187)2.47606657
140fatty acid catabolic process (GO:0009062)2.47410163
141glyoxylate metabolic process (GO:0046487)2.46946381
142substantia nigra development (GO:0021762)2.46014471
143negative regulation of neurotransmitter transport (GO:0051589)2.44818577
144GPI anchor biosynthetic process (GO:0006506)2.44599641
145sulfur amino acid catabolic process (GO:0000098)2.44521557
146acyl-CoA metabolic process (GO:0006637)2.44466363
147thioester metabolic process (GO:0035383)2.44466363
148regulation of cholesterol esterification (GO:0010872)2.44320415
149mitochondrial respiratory chain complex assembly (GO:0033108)2.43631177
150long-chain fatty acid biosynthetic process (GO:0042759)2.42926327
151GPI anchor metabolic process (GO:0006505)2.41015749
152fatty acid beta-oxidation (GO:0006635)2.39585820
153water-soluble vitamin biosynthetic process (GO:0042364)2.38680671
154lipid oxidation (GO:0034440)2.37773188
155photoreceptor cell differentiation (GO:0046530)2.36148434
156eye photoreceptor cell differentiation (GO:0001754)2.36148434
157regulation of beta-amyloid formation (GO:1902003)2.36050961
158creatine metabolic process (GO:0006600)2.35879647
159tyrosine metabolic process (GO:0006570)2.35345337
160ketone body metabolic process (GO:1902224)2.33451101
161fatty acid oxidation (GO:0019395)2.32127976
162glutathione metabolic process (GO:0006749)2.31626667
163glutathione derivative metabolic process (GO:1901685)2.30489881
164glutathione derivative biosynthetic process (GO:1901687)2.30489881
165branched-chain amino acid metabolic process (GO:0009081)2.30485230
166aromatic amino acid family metabolic process (GO:0009072)2.27767171
167response to misfolded protein (GO:0051788)2.27403789
168purine ribonucleotide transport (GO:0015868)2.27099979
169C4-dicarboxylate transport (GO:0015740)2.27023691
170monocarboxylic acid catabolic process (GO:0072329)2.26993929
171triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.26487634
172positive regulation of amino acid transport (GO:0051957)2.26102802
173fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.24337720
174peptide biosynthetic process (GO:0043043)2.24295982
175negative regulation of neurotransmitter secretion (GO:0046929)2.23022934
176regulation of cholesterol biosynthetic process (GO:0045540)2.22695331
177bile acid metabolic process (GO:0008206)2.21709080
178glycerophospholipid catabolic process (GO:0046475)2.21288458
179neurotransmitter uptake (GO:0001504)2.20641237
180hydrogen transport (GO:0006818)2.19287539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.61863644
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.07378831
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.76454066
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32484984
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.18358824
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09238031
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03458015
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.00847648
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.00569149
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92052729
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91679603
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.86357830
13GBX2_23144817_ChIP-Seq_PC3_Human2.73144037
14VDR_23849224_ChIP-Seq_CD4+_Human2.67960604
15ELK1_19687146_ChIP-ChIP_HELA_Human2.58306206
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58120853
17E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36599424
18FOXP3_21729870_ChIP-Seq_TREG_Human2.33116226
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32447740
20DCP1A_22483619_ChIP-Seq_HELA_Human2.23487463
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16978325
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15447185
23RXR_22158963_ChIP-Seq_LIVER_Mouse2.13372002
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11431448
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.07589257
26GABP_19822575_ChIP-Seq_HepG2_Human1.99601724
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.99448147
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99434676
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96387108
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94554956
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94428296
32TAF15_26573619_Chip-Seq_HEK293_Human1.92479430
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89587682
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88123301
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87765968
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86413366
37EZH2_22144423_ChIP-Seq_EOC_Human1.85413720
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84740742
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84453913
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84009065
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82315449
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81509982
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80396128
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79812851
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.77937395
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77494516
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74516955
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73264677
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.73031733
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72416100
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72382336
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67868165
53VDR_22108803_ChIP-Seq_LS180_Human1.67786609
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65973725
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65229964
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.64046241
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59870953
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59870953
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58767477
60TTF2_22483619_ChIP-Seq_HELA_Human1.56698727
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54414666
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52441999
63HTT_18923047_ChIP-ChIP_STHdh_Human1.52232641
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.51660480
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51359899
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49694984
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49557619
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.48472929
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48263078
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45967591
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44915597
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44831879
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.44759474
74XRN2_22483619_ChIP-Seq_HELA_Human1.44511440
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43065009
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40413329
77AR_21572438_ChIP-Seq_LNCaP_Human1.40001334
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38928333
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.37842584
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35714107
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35714107
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35681102
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35671323
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.35526485
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34530605
86P300_19829295_ChIP-Seq_ESCs_Human1.34188116
87MYC_18940864_ChIP-ChIP_HL60_Human1.33087044
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.32467393
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.31721724
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26345779
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25333709
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24515592
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24274424
94ER_23166858_ChIP-Seq_MCF-7_Human1.22730542
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20509232
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18723882
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18475337
98KDM5A_27292631_Chip-Seq_BREAST_Human1.18022975
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17873656
100BP1_19119308_ChIP-ChIP_Hs578T_Human1.17296232
101TFEB_21752829_ChIP-Seq_HELA_Human1.16412478
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15975093
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12515616
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12008134
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11336928
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10153274
107E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09278005
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08478953
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08407303
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08054681
111RNF2_27304074_Chip-Seq_ESCs_Mouse1.07541930
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06349342
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05627407
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05578914
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.04983410
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04358365
117ZNF263_19887448_ChIP-Seq_K562_Human1.03084160
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02828927
119REST_21632747_ChIP-Seq_MESCs_Mouse1.02263571
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02078140
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01822766
122SOX2_19829295_ChIP-Seq_ESCs_Human1.00085869
123NANOG_19829295_ChIP-Seq_ESCs_Human1.00085869
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99708295
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98986387
126IGF1R_20145208_ChIP-Seq_DFB_Human0.97650843
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97349543
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.96999860
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96818283
130REST_18959480_ChIP-ChIP_MESCs_Mouse0.96737900
131FUS_26573619_Chip-Seq_HEK293_Human0.95743370
132NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94995210
133AR_20517297_ChIP-Seq_VCAP_Human0.93429498
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93380351
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92747400
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92301858
137SMAD4_21799915_ChIP-Seq_A2780_Human0.90769176
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90614528
139MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90393985
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89961757
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89032854
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89005494
143SOX17_20123909_ChIP-Seq_XEN_Mouse0.88251280
144TP53_22573176_ChIP-Seq_HFKS_Human0.87426375
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85539928
146ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84391406
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83496931
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83430110
149ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83257864
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83112643
151SRF_21415370_ChIP-Seq_HL-1_Mouse0.82780888
152BCAT_22108803_ChIP-Seq_LS180_Human0.81841765
153KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.81409845
154HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81251560
155NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81219409
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80926284
157EOMES_21245162_ChIP-Seq_HESCs_Human0.80655607
158ELF5_23300383_ChIP-Seq_T47D_Human0.80513213
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.80481797
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80463680
161SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80453818
162ERG_20517297_ChIP-Seq_VCAP_Human0.80329354
163HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80283926
164AR_25329375_ChIP-Seq_VCAP_Human0.78476004
165GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78095669
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78003523
167FLI1_27457419_Chip-Seq_LIVER_Mouse0.77892694
168PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77854947
169KDM2B_26808549_Chip-Seq_REH_Human0.77431376
170TP53_18474530_ChIP-ChIP_U2OS_Human0.77253937
171STAT3_18555785_Chip-Seq_ESCs_Mouse0.77170578
172TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76221761
173ERG_21242973_ChIP-ChIP_JURKAT_Human0.76196101
174RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76080351
175ZNF274_21170338_ChIP-Seq_K562_Hela0.75580661
176IRF1_19129219_ChIP-ChIP_H3396_Human0.75461353
177FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75276535
178TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75227805
179NANOG_16153702_ChIP-ChIP_HESCs_Human0.75131832
180TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75032597
181CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75024490
182FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73569737
183FOXA1_25329375_ChIP-Seq_VCAP_Human0.73569737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.23303278
2MP0003195_calcinosis3.09635363
3MP0003880_abnormal_central_pattern2.87845527
4MP0004043_abnormal_pH_regulation2.78794145
5MP0005360_urolithiasis2.69570769
6MP0008875_abnormal_xenobiotic_pharmacok2.41611692
7MP0003690_abnormal_glial_cell2.38776962
8MP0005365_abnormal_bile_salt2.29205518
9MP0003786_premature_aging2.28294669
10MP0003329_amyloid_beta_deposits2.27110500
11MP0000920_abnormal_myelination2.26056404
12MP0008058_abnormal_DNA_repair2.18346701
13MP0009697_abnormal_copulation2.13580067
14MP0002163_abnormal_gland_morphology2.13042224
15MP0005645_abnormal_hypothalamus_physiol2.11440658
16MP0000013_abnormal_adipose_tissue2.10978387
17MP0005085_abnormal_gallbladder_physiolo2.10738725
18MP0002837_dystrophic_cardiac_calcinosis2.00203480
19MP0005332_abnormal_amino_acid1.98145795
20MP0006054_spinal_hemorrhage1.95314936
21MP0005075_abnormal_melanosome_morpholog1.91725651
22MP0005646_abnormal_pituitary_gland1.87052205
23MP0001905_abnormal_dopamine_level1.86849821
24MP0001529_abnormal_vocalization1.82958929
25MP0002876_abnormal_thyroid_physiology1.80996950
26MP0005171_absent_coat_pigmentation1.77889364
27MP0003718_maternal_effect1.74018529
28MP0002254_reproductive_system_inflammat1.73853573
29MP0003806_abnormal_nucleotide_metabolis1.67952543
30MP0001661_extended_life_span1.65403493
31MP0009780_abnormal_chondrocyte_physiolo1.60989708
32MP0006035_abnormal_mitochondrial_morpho1.59846495
33MP0002938_white_spotting1.57982896
34MP0004142_abnormal_muscle_tone1.57038577
35MP0000516_abnormal_urinary_system1.54915170
36MP0005367_renal/urinary_system_phenotyp1.54915170
37MP0005379_endocrine/exocrine_gland_phen1.53774514
38MP0005423_abnormal_somatic_nervous1.53125762
39MP0002272_abnormal_nervous_system1.52392418
40MP0001986_abnormal_taste_sensitivity1.50585420
41MP0005165_increased_susceptibility_to1.50222494
42MP0005058_abnormal_lysosome_morphology1.49935103
43MP0001542_abnormal_bone_strength1.49557569
44MP0009840_abnormal_foam_cell1.49215922
45MP0000604_amyloidosis1.47576789
46MP0004885_abnormal_endolymph1.44737864
47MP0002064_seizures1.44205147
48MP0003634_abnormal_glial_cell1.44019764
49MP0002638_abnormal_pupillary_reflex1.42208267
50MP0000358_abnormal_cell_content/1.40770902
51MP0008007_abnormal_cellular_replicative1.40186108
52MP0005330_cardiomyopathy1.39901714
53MP0004147_increased_porphyrin_level1.39649735
54MP0001486_abnormal_startle_reflex1.37444232
55MP0010329_abnormal_lipoprotein_level1.34231619
56MP0005551_abnormal_eye_electrophysiolog1.33247354
57MP0001756_abnormal_urination1.32273125
58MP0002118_abnormal_lipid_homeostasis1.29739826
59MP0010386_abnormal_urinary_bladder1.28750935
60MP0003136_yellow_coat_color1.25716613
61MP0002295_abnormal_pulmonary_circulatio1.24977742
62MP0003186_abnormal_redox_activity1.22260450
63MP0004270_analgesia1.21559026
64MP0009745_abnormal_behavioral_response1.21262133
65MP0004019_abnormal_vitamin_homeostasis1.20486553
66MP0005408_hypopigmentation1.20334499
67MP0002132_abnormal_respiratory_system1.18898714
68MP0005410_abnormal_fertilization1.17394237
69MP0005319_abnormal_enzyme/_coenzyme1.16998548
70MP0003950_abnormal_plasma_membrane1.16685210
71MP0003011_delayed_dark_adaptation1.16416007
72MP0006276_abnormal_autonomic_nervous1.15912107
73MP0000566_synostosis1.15401188
74MP0001666_abnormal_nutrient_absorption1.14628305
75MP0002572_abnormal_emotion/affect_behav1.14174572
76MP0005636_abnormal_mineral_homeostasis1.13425507
77MP0003183_abnormal_peptide_metabolism1.13174751
78MP0001764_abnormal_homeostasis1.11523788
79MP0003693_abnormal_embryo_hatching1.11267950
80MP0004957_abnormal_blastocyst_morpholog1.10507864
81MP0009384_cardiac_valve_regurgitation1.09750876
82MP0000230_abnormal_systemic_arterial1.08303338
83MP0003941_abnormal_skin_development1.07492115
84MP0006036_abnormal_mitochondrial_physio1.06186790
85MP0005535_abnormal_body_temperature1.04438464
86MP0002277_abnormal_respiratory_mucosa1.03771832
87MP0005584_abnormal_enzyme/coenzyme_acti1.02709886
88MP0006082_CNS_inflammation1.02566635
89MP0009643_abnormal_urine_homeostasis1.02432409
90MP0002229_neurodegeneration1.02302979
91MP0008932_abnormal_embryonic_tissue1.01776416
92MP0003635_abnormal_synaptic_transmissio1.01395900
93MP0001502_abnormal_circadian_rhythm1.01052715
94MP0009046_muscle_twitch1.00777308
95MP0002090_abnormal_vision1.00342628
96MP0010094_abnormal_chromosome_stability1.00059304
97MP0005083_abnormal_biliary_tract0.99898598
98MP0004742_abnormal_vestibular_system0.98590252
99MP0001440_abnormal_grooming_behavior0.98127836
100MP0001853_heart_inflammation0.97297241
101MP0002736_abnormal_nociception_after0.96484289
102MP0003191_abnormal_cellular_cholesterol0.96284551
103MP0001984_abnormal_olfaction0.96081147
104MP0001243_abnormal_dermal_layer0.95897061
105MP0002148_abnormal_hypersensitivity_rea0.95779614
106MP0008438_abnormal_cutaneous_collagen0.95775945
107MP0002693_abnormal_pancreas_physiology0.95723993
108MP0005451_abnormal_body_composition0.95235433
109MP0003633_abnormal_nervous_system0.94243265
110MP0002734_abnormal_mechanical_nocicepti0.93548023
111MP0006072_abnormal_retinal_apoptosis0.92812505
112MP0002909_abnormal_adrenal_gland0.92204863
113MP0001501_abnormal_sleep_pattern0.91915440
114MP0001944_abnormal_pancreas_morphology0.91181060
115MP0005220_abnormal_exocrine_pancreas0.90516122
116MP0001963_abnormal_hearing_physiology0.90449872
117MP0003172_abnormal_lysosome_physiology0.89358962
118MP0008789_abnormal_olfactory_epithelium0.88090427
119MP0005253_abnormal_eye_physiology0.87137744
120MP0000538_abnormal_urinary_bladder0.86964232
121MP0004134_abnormal_chest_morphology0.86745662
122MP0000749_muscle_degeneration0.86583075
123MP0001485_abnormal_pinna_reflex0.85545594
124MP0000003_abnormal_adipose_tissue0.85353241
125MP0001765_abnormal_ion_homeostasis0.85247376
126MP0000343_altered_response_to0.85125198
127MP0005595_abnormal_vascular_smooth0.84262274
128MP0002078_abnormal_glucose_homeostasis0.83414868
129MP0005084_abnormal_gallbladder_morpholo0.80886540
130MP0003631_nervous_system_phenotype0.80638061
131MP0005389_reproductive_system_phenotype0.80366137
132MP0003122_maternal_imprinting0.80004160
133MP0000639_abnormal_adrenal_gland0.79941827
134MP0008872_abnormal_physiological_respon0.79911510
135MP0002063_abnormal_learning/memory/cond0.79909341
136MP0002067_abnormal_sensory_capabilities0.79834215
137MP0001968_abnormal_touch/_nociception0.79294047
138MP0001970_abnormal_pain_threshold0.79041193
139MP0001881_abnormal_mammary_gland0.77806459
140MP0008995_early_reproductive_senescence0.77748225
141MP0001727_abnormal_embryo_implantation0.76557683
142MP0003075_altered_response_to0.76381026
143MP0004215_abnormal_myocardial_fiber0.76141052
144MP0000462_abnormal_digestive_system0.76051374
145MP0004272_abnormal_basement_membrane0.75894648
146MP0000372_irregular_coat_pigmentation0.75746007
147MP0000026_abnormal_inner_ear0.75607948
148MP0005503_abnormal_tendon_morphology0.74701201
149MP0002733_abnormal_thermal_nociception0.74041808
150MP0003632_abnormal_nervous_system0.74037381
151MP0008469_abnormal_protein_level0.73325794
152MP0003283_abnormal_digestive_organ0.67653598
153MP0002060_abnormal_skin_morphology0.65382201
154MP0005670_abnormal_white_adipose0.64564200
155MP0005395_other_phenotype0.64453416
156MP0003137_abnormal_impulse_conducting0.63065110

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)4.51701343
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.51701343
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.19343854
4Neurofibrillary tangles (HP:0002185)4.14684416
5Acute necrotizing encephalopathy (HP:0006965)4.06380691
6Type I transferrin isoform profile (HP:0003642)4.00045053
7Acute encephalopathy (HP:0006846)3.79940386
8Abnormal mitochondria in muscle tissue (HP:0008316)3.72022005
9Mitochondrial inheritance (HP:0001427)3.62120623
10Hepatocellular necrosis (HP:0001404)3.45579233
11Hepatic necrosis (HP:0002605)3.43947526
12Progressive macrocephaly (HP:0004481)3.35066869
13Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.14425241
14Abnormal protein N-linked glycosylation (HP:0012347)3.14425241
15Abnormal protein glycosylation (HP:0012346)3.14425241
16Abnormal glycosylation (HP:0012345)3.14425241
17Renal Fanconi syndrome (HP:0001994)3.13693024
18Increased serum lactate (HP:0002151)3.08744978
19Increased CSF lactate (HP:0002490)3.00204548
20Cerebral edema (HP:0002181)2.97380072
21Ketoacidosis (HP:0001993)2.86105963
22Hypoglycemic coma (HP:0001325)2.79343428
23Ketosis (HP:0001946)2.76796156
24Lipid accumulation in hepatocytes (HP:0006561)2.73843778
25Cerebral inclusion bodies (HP:0100314)2.71799164
26Microvesicular hepatic steatosis (HP:0001414)2.71470848
27Increased hepatocellular lipid droplets (HP:0006565)2.65187405
28Prolonged partial thromboplastin time (HP:0003645)2.64804868
29Hyperlipoproteinemia (HP:0010980)2.63586835
30Intrahepatic cholestasis (HP:0001406)2.58185860
31Abnormality of glycine metabolism (HP:0010895)2.57877820
32Abnormality of serine family amino acid metabolism (HP:0010894)2.57877820
33Hypoglycemic seizures (HP:0002173)2.56986735
34Leukodystrophy (HP:0002415)2.52575339
35Methylmalonic acidemia (HP:0002912)2.48906902
36Exertional dyspnea (HP:0002875)2.46910041
373-Methylglutaconic aciduria (HP:0003535)2.46330234
38Abnormality of methionine metabolism (HP:0010901)2.45298860
39Glycosuria (HP:0003076)2.44103319
40Abnormality of urine glucose concentration (HP:0011016)2.44103319
41Abnormality of liposaccharide metabolism (HP:0010968)2.42491455
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.42491455
43Abnormality of glycolipid metabolism (HP:0010969)2.42491455
44Generalized aminoaciduria (HP:0002909)2.40446552
45Abnormality of glycolysis (HP:0004366)2.39625079
46Increased serum pyruvate (HP:0003542)2.39625079
47Hyperglycinemia (HP:0002154)2.37986494
48Reduced antithrombin III activity (HP:0001976)2.37576261
49Abnormality of renal resorption (HP:0011038)2.37335461
50Xanthomatosis (HP:0000991)2.36135606
51Palpitations (HP:0001962)2.35774713
52Abnormality of fatty-acid metabolism (HP:0004359)2.34695051
53Symptomatic seizures (HP:0011145)2.31931048
54Increased circulating renin level (HP:0000848)2.30842844
55Hyperinsulinemic hypoglycemia (HP:0000825)2.30248496
56Progressive neurologic deterioration (HP:0002344)2.29844968
57Methylmalonic aciduria (HP:0012120)2.29672502
58Lactic acidosis (HP:0003128)2.29396349
59Pheochromocytoma (HP:0002666)2.28714946
60Emotional lability (HP:0000712)2.27658608
61Retinal dysplasia (HP:0007973)2.27578147
62Hyperglycinuria (HP:0003108)2.27396971
63Lethargy (HP:0001254)2.27310613
64Hypokalemic alkalosis (HP:0001949)2.26697792
65Spastic paraparesis (HP:0002313)2.25553148
66Testicular atrophy (HP:0000029)2.25298246
67Neuroendocrine neoplasm (HP:0100634)2.23960476
68Increased intramyocellular lipid droplets (HP:0012240)2.23292385
69Increased muscle lipid content (HP:0009058)2.22007006
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21806710
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21185954
72Dicarboxylic aciduria (HP:0003215)2.21185954
73Respiratory failure (HP:0002878)2.18986938
74Prolonged neonatal jaundice (HP:0006579)2.15435039
75Optic disc pallor (HP:0000543)2.11612108
76Vacuolated lymphocytes (HP:0001922)2.10556112
77Cerebral hemorrhage (HP:0001342)2.06806523
78Metabolic alkalosis (HP:0200114)2.06080384
79Humeroradial synostosis (HP:0003041)2.04932482
80Synostosis involving the elbow (HP:0003938)2.04932482
81Hyperphosphaturia (HP:0003109)2.04909431
82Pancreatic cysts (HP:0001737)2.04717960
83Abnormal number of erythroid precursors (HP:0012131)2.01087474
84CNS demyelination (HP:0007305)2.00146722
85Parakeratosis (HP:0001036)1.99433340
86Hypomagnesemia (HP:0002917)1.99347260
87Rhabdomyolysis (HP:0003201)1.97771754
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97504366
89Degeneration of the lateral corticospinal tracts (HP:0002314)1.97504366
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95605196
91Aplasia involving bones of the upper limbs (HP:0009823)1.94954694
92Aplasia of the phalanges of the hand (HP:0009802)1.94954694
93Aplasia involving bones of the extremities (HP:0009825)1.94954694
94Conjugated hyperbilirubinemia (HP:0002908)1.94772221
95Aplasia/hypoplasia of the uterus (HP:0008684)1.93130001
96Opisthotonus (HP:0002179)1.92396628
97Nausea (HP:0002018)1.91201587
98Hypothermia (HP:0002045)1.91173619
99Split foot (HP:0001839)1.89807000
100Pancreatic fibrosis (HP:0100732)1.89452362
101True hermaphroditism (HP:0010459)1.88765755
102Cerebral palsy (HP:0100021)1.88014511
103Dysostosis multiplex (HP:0000943)1.87690167
104Abnormality of vitamin B metabolism (HP:0004340)1.87273461
105Gout (HP:0001997)1.86917880
106Abnormality of the axillary hair (HP:0100134)1.86675034
107Abnormality of secondary sexual hair (HP:0009888)1.86675034
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86455731
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86381753
110Abnormality of the anterior horn cell (HP:0006802)1.86233274
111Degeneration of anterior horn cells (HP:0002398)1.86233274
112Myoglobinuria (HP:0002913)1.85745406
113Respiratory difficulties (HP:0002880)1.85277176
114Delayed CNS myelination (HP:0002188)1.85103415
115Medial flaring of the eyebrow (HP:0010747)1.84221736
116Vomiting (HP:0002013)1.83446641
117Exercise intolerance (HP:0003546)1.83286472
118Aplastic anemia (HP:0001915)1.82991155
119Petechiae (HP:0000967)1.82879399
120Pancytopenia (HP:0001876)1.82257614
121Patchy hypopigmentation of hair (HP:0011365)1.81612548
122Renal cortical cysts (HP:0000803)1.79428021
123Renal tubular dysfunction (HP:0000124)1.79063192
124Pancreatic islet-cell hyperplasia (HP:0004510)1.78410345
125Hyperammonemia (HP:0001987)1.77665078
126Vertebral compression fractures (HP:0002953)1.77396007
127Abnormality of magnesium homeostasis (HP:0004921)1.76858229
128Beaking of vertebral bodies (HP:0004568)1.76639943
129Paraparesis (HP:0002385)1.76316939
130Alkalosis (HP:0001948)1.75589632
131Large for gestational age (HP:0001520)1.75162021
132Abnormal biliary tract physiology (HP:0012439)1.75148136
133Bile duct proliferation (HP:0001408)1.75148136
134X-linked dominant inheritance (HP:0001423)1.74510900
135Gait imbalance (HP:0002141)1.74351170
136Brushfield spots (HP:0001088)1.74227668
137Congenital primary aphakia (HP:0007707)1.73138089
138Fat malabsorption (HP:0002630)1.73108280
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72478728
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72043481
141Abnormal urine phosphate concentration (HP:0012599)1.71866481
142Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71514882
143Metabolic acidosis (HP:0001942)1.70486776
144Supranuclear gaze palsy (HP:0000605)1.69958295
145Blindness (HP:0000618)1.69945040
146Congenital, generalized hypertrichosis (HP:0004540)1.69810166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.71357172
2STK393.37212506
3OXSR13.30007527
4MAPK153.25519712
5TESK23.09589036
6CASK2.73551835
7MUSK2.67072830
8INSRR2.66971429
9STK162.66171403
10BCKDK2.62871942
11NME22.60720895
12WNK42.56462209
13ARAF2.47665768
14BUB12.43012118
15TESK12.38539113
16MAP4K22.29272986
17ZAK2.08436834
18EIF2AK12.03402677
19NEK12.02091747
20WNK31.95578414
21PIM21.89218372
22TNIK1.88417279
23BCR1.82357116
24NUAK11.80459889
25SCYL21.80423837
26PBK1.78940282
27MAPKAPK31.72867874
28EPHA41.68786773
29MAPKAPK51.67398677
30PIK3CG1.46138735
31MST41.44942461
32MET1.42404557
33NEK61.41334569
34PKN11.40544762
35NME11.37732025
36MYLK1.36508364
37CAMK2B1.35277083
38ADRBK21.35097432
39BMPR1B1.29409295
40SRPK11.28953717
41DAPK11.28193762
42EPHB11.25409048
43PHKG11.24310396
44PHKG21.24310396
45SGK4941.24119444
46SGK2231.24119444
47CDK191.23894314
48GRK71.20925155
49FRK1.20113467
50CAMK2G1.15279936
51PAK41.14248789
52PRKCE1.12020820
53NTRK11.11397290
54CAMK2D1.10100700
55ILK1.09352480
56CAMK2A1.05450676
57NTRK31.04486723
58FLT31.00965253
59CSNK1G31.00626608
60MAP2K70.99519688
61CAMKK20.98087771
62PINK10.97530394
63LIMK10.94888242
64PLK30.92261681
65UHMK10.91625533
66TLK10.91193545
67BMPR20.89810523
68GRK50.88901626
69SIK10.86868659
70MAPK130.86736205
71DAPK30.85926306
72PAK30.84235827
73ERBB30.81574921
74BRAF0.80745221
75LMTK20.80190752
76DYRK20.80075689
77ERBB40.80030889
78CCNB10.78636328
79TIE10.78512849
80FGFR20.75523774
81FER0.75459963
82CSNK1A1L0.74979288
83OBSCN0.74424969
84EPHA20.73939768
85RPS6KA50.72903458
86PRPF4B0.71963316
87ADRBK10.71530441
88CDK80.71448818
89CSNK1G10.70271470
90ROCK20.69745838
91EIF2AK30.69010875
92PRKCG0.68990147
93IRAK10.68819160
94TRIM280.67525827
95NTRK20.65967932
96CSNK1G20.64522979
97PRKACA0.63999857
98CDK50.62430767
99PLK10.62344104
100VRK10.61505843
101MST1R0.60564107
102WNK10.60496106
103TXK0.59046158
104GRK10.58795744
105FGR0.58412424
106MAP3K130.58125979
107MAPK120.58083065
108PRKCQ0.57893261
109TAF10.57591420
110TTK0.57223751
111PLK40.56612030
112CDK30.54038204
113CSNK2A10.52762585
114AURKB0.52729863
115PRKG10.52505143
116IRAK30.52176487
117ABL20.51739111
118PRKCI0.51702522
119AKT30.50197581
120IRAK20.49855866
121STK40.49420425
122AURKA0.49262794
123RPS6KA40.46929066
124MAPK70.46661264
125TNK20.46525189
126PDK20.46419542
127CSNK2A20.46385840
128PRKCH0.45912473
129PNCK0.45336939
130PRKCA0.45171513
131IKBKB0.45043717
132MOS0.44388497
133KDR0.43452725
134LRRK20.43316230
135PAK10.43255419
136DYRK1A0.42871556
137TBK10.42757042
138MAP3K20.41538887
139PDPK10.41491874
140EPHA30.40866739
141CSNK1A10.40476774
142PLK20.40419521
143MAP3K120.40164390
144TRPM70.38155387
145CDC70.35048525
146PRKACG0.34437178
147IGF1R0.33738943
148MARK10.33096384
149ATR0.31745751
150PASK0.30888219
151EIF2AK20.30012997
152STK38L0.28355939
153RPS6KB20.28059624
154ROCK10.23844921
155BRSK10.23135887
156MAP2K60.22163227
157MAPK110.21959605

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.29465705
2Fatty acid elongation_Homo sapiens_hsa000623.03920197
3Protein export_Homo sapiens_hsa030602.93698952
4Sulfur metabolism_Homo sapiens_hsa009202.77279761
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71961143
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48678254
7Ribosome_Homo sapiens_hsa030102.45112888
8Parkinsons disease_Homo sapiens_hsa050122.36190049
9Steroid biosynthesis_Homo sapiens_hsa001002.26085782
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23305794
11Butanoate metabolism_Homo sapiens_hsa006502.14338420
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10553930
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.08910197
14Alzheimers disease_Homo sapiens_hsa050102.01207549
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.00089225
16RNA polymerase_Homo sapiens_hsa030201.91493099
17Propanoate metabolism_Homo sapiens_hsa006401.86979880
18Mismatch repair_Homo sapiens_hsa034301.80650354
19Peroxisome_Homo sapiens_hsa041461.80232997
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77959702
21Histidine metabolism_Homo sapiens_hsa003401.76702244
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76045441
23Fatty acid degradation_Homo sapiens_hsa000711.74101643
24Fatty acid metabolism_Homo sapiens_hsa012121.72428990
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68230666
26DNA replication_Homo sapiens_hsa030301.67140962
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65032638
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62935721
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56604161
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55893527
31Homologous recombination_Homo sapiens_hsa034401.52077380
32Collecting duct acid secretion_Homo sapiens_hsa049661.51200741
33Nitrogen metabolism_Homo sapiens_hsa009101.49319165
34Base excision repair_Homo sapiens_hsa034101.48501061
35Huntingtons disease_Homo sapiens_hsa050161.44005517
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43745367
37Pyrimidine metabolism_Homo sapiens_hsa002401.41318746
38Tryptophan metabolism_Homo sapiens_hsa003801.37752894
39Pyruvate metabolism_Homo sapiens_hsa006201.37028845
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33283988
41Folate biosynthesis_Homo sapiens_hsa007901.32819369
42Chemical carcinogenesis_Homo sapiens_hsa052041.28395385
43One carbon pool by folate_Homo sapiens_hsa006701.27981938
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26047430
45Vibrio cholerae infection_Homo sapiens_hsa051101.24587815
46Nucleotide excision repair_Homo sapiens_hsa034201.21769570
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21053146
48beta-Alanine metabolism_Homo sapiens_hsa004101.20083364
49Ether lipid metabolism_Homo sapiens_hsa005651.19955259
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.19316106
51N-Glycan biosynthesis_Homo sapiens_hsa005101.18533582
52Vitamin B6 metabolism_Homo sapiens_hsa007501.15743779
53Sphingolipid metabolism_Homo sapiens_hsa006001.14599175
54PPAR signaling pathway_Homo sapiens_hsa033201.14545167
55Purine metabolism_Homo sapiens_hsa002301.10759095
56Arginine and proline metabolism_Homo sapiens_hsa003301.10126004
57Tyrosine metabolism_Homo sapiens_hsa003501.06096435
58Non-homologous end-joining_Homo sapiens_hsa034501.04676089
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00956175
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00613954
61Complement and coagulation cascades_Homo sapiens_hsa046100.96249969
62Phenylalanine metabolism_Homo sapiens_hsa003600.94248164
63Glutathione metabolism_Homo sapiens_hsa004800.93621227
64Lysosome_Homo sapiens_hsa041420.92803626
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89281358
66Cardiac muscle contraction_Homo sapiens_hsa042600.88194887
67Biosynthesis of amino acids_Homo sapiens_hsa012300.87725222
68Metabolic pathways_Homo sapiens_hsa011000.87521975
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87446453
70Fanconi anemia pathway_Homo sapiens_hsa034600.86877637
71Spliceosome_Homo sapiens_hsa030400.85996219
72GABAergic synapse_Homo sapiens_hsa047270.85678555
73Vitamin digestion and absorption_Homo sapiens_hsa049770.85621931
74Other glycan degradation_Homo sapiens_hsa005110.84647781
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84290194
76Linoleic acid metabolism_Homo sapiens_hsa005910.83382467
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81990025
78Retinol metabolism_Homo sapiens_hsa008300.80193212
79RNA degradation_Homo sapiens_hsa030180.79868243
80Pentose phosphate pathway_Homo sapiens_hsa000300.78065870
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77511665
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76347827
83Arachidonic acid metabolism_Homo sapiens_hsa005900.74134525
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72349470
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72266025
86Rheumatoid arthritis_Homo sapiens_hsa053230.71560127
87Galactose metabolism_Homo sapiens_hsa000520.70281731
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69228222
89Nicotine addiction_Homo sapiens_hsa050330.68706108
90Arginine biosynthesis_Homo sapiens_hsa002200.68364674
91Starch and sucrose metabolism_Homo sapiens_hsa005000.68130248
92RNA transport_Homo sapiens_hsa030130.65613461
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65190351
94Selenocompound metabolism_Homo sapiens_hsa004500.64748917
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63167102
96Fatty acid biosynthesis_Homo sapiens_hsa000610.63135360
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62776206
98Fructose and mannose metabolism_Homo sapiens_hsa000510.62299019
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61057610
100Bile secretion_Homo sapiens_hsa049760.58549582
101Regulation of autophagy_Homo sapiens_hsa041400.57475760
102Type I diabetes mellitus_Homo sapiens_hsa049400.55560398
103Asthma_Homo sapiens_hsa053100.55068470
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54664274
105Carbon metabolism_Homo sapiens_hsa012000.53138963
106Insulin secretion_Homo sapiens_hsa049110.52956870
107Synaptic vesicle cycle_Homo sapiens_hsa047210.52761226
108Sulfur relay system_Homo sapiens_hsa041220.51318354
109Glycerolipid metabolism_Homo sapiens_hsa005610.51270464
110Serotonergic synapse_Homo sapiens_hsa047260.50660774
111Basal transcription factors_Homo sapiens_hsa030220.49311005
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.47271903
113Taste transduction_Homo sapiens_hsa047420.44897074
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.44790772
115Primary immunodeficiency_Homo sapiens_hsa053400.44161318
116Fat digestion and absorption_Homo sapiens_hsa049750.43808861
117Antigen processing and presentation_Homo sapiens_hsa046120.43764219
118Prion diseases_Homo sapiens_hsa050200.43246664
119ABC transporters_Homo sapiens_hsa020100.42964026
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.42476296
121Systemic lupus erythematosus_Homo sapiens_hsa053220.42157342
122Phototransduction_Homo sapiens_hsa047440.41972712
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41927430
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41689033
125Cocaine addiction_Homo sapiens_hsa050300.41661147
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40758483
127Phagosome_Homo sapiens_hsa041450.40425190
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39628765
129Autoimmune thyroid disease_Homo sapiens_hsa053200.38451648
130Glutamatergic synapse_Homo sapiens_hsa047240.37100860
131Morphine addiction_Homo sapiens_hsa050320.35321674
132Proteasome_Homo sapiens_hsa030500.34741049
133Caffeine metabolism_Homo sapiens_hsa002320.33988560
134Mineral absorption_Homo sapiens_hsa049780.33819975
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.31654330
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30898726

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