ATRIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.28033558
2proteasome assembly (GO:0043248)5.30481484
3ribosome assembly (GO:0042255)5.27532818
4mitotic chromosome condensation (GO:0007076)4.90681060
5DNA unwinding involved in DNA replication (GO:0006268)4.72163503
6telomere maintenance via semi-conservative replication (GO:0032201)4.67126343
7rRNA modification (GO:0000154)4.66816411
8ribosomal small subunit biogenesis (GO:0042274)4.63962408
9transcription elongation from RNA polymerase III promoter (GO:0006385)4.62192553
10termination of RNA polymerase III transcription (GO:0006386)4.62192553
11maturation of SSU-rRNA (GO:0030490)4.55148138
12regulation of nuclear cell cycle DNA replication (GO:0033262)4.44393014
13DNA strand elongation involved in DNA replication (GO:0006271)4.41139711
14ribosomal large subunit biogenesis (GO:0042273)4.34644316
15DNA replication checkpoint (GO:0000076)4.29861018
16ribonucleoprotein complex biogenesis (GO:0022613)4.28593892
17deoxyribonucleotide biosynthetic process (GO:0009263)4.26559355
18ribosome biogenesis (GO:0042254)4.21499823
19DNA strand elongation (GO:0022616)4.19497198
20DNA replication initiation (GO:0006270)4.12376033
21nuclear pore complex assembly (GO:0051292)4.08276823
22telomere maintenance via recombination (GO:0000722)4.07140510
23spliceosomal snRNP assembly (GO:0000387)4.03869389
247-methylguanosine mRNA capping (GO:0006370)3.99414583
25deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.98469094
26RNA capping (GO:0036260)3.90538367
277-methylguanosine RNA capping (GO:0009452)3.90538367
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87368149
29pseudouridine synthesis (GO:0001522)3.83805220
30protein-cofactor linkage (GO:0018065)3.81353275
31DNA damage response, detection of DNA damage (GO:0042769)3.81089688
32ribosomal small subunit assembly (GO:0000028)3.79327859
33telomere maintenance via telomere lengthening (GO:0010833)3.76037209
34mitotic sister chromatid segregation (GO:0000070)3.74350012
35rRNA processing (GO:0006364)3.74258723
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74066406
37nucleobase biosynthetic process (GO:0046112)3.73908627
38mitochondrial DNA replication (GO:0006264)3.73439697
39transcription-coupled nucleotide-excision repair (GO:0006283)3.72539845
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.69750614
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68777796
42mitotic recombination (GO:0006312)3.68346865
43deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.68294809
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68145188
45DNA-dependent DNA replication (GO:0006261)3.68082825
46purine nucleobase biosynthetic process (GO:0009113)3.66742612
47maturation of 5.8S rRNA (GO:0000460)3.66349818
48viral transcription (GO:0019083)3.63462757
49rRNA metabolic process (GO:0016072)3.62473488
50CENP-A containing nucleosome assembly (GO:0034080)3.61642244
51spliceosomal complex assembly (GO:0000245)3.60536909
52mitotic metaphase plate congression (GO:0007080)3.59311706
53DNA duplex unwinding (GO:0032508)3.58817135
54transcription from RNA polymerase I promoter (GO:0006360)3.58620236
55ncRNA 3-end processing (GO:0043628)3.57846169
56translational termination (GO:0006415)3.55696977
57termination of RNA polymerase I transcription (GO:0006363)3.55433752
58regulation of mitochondrial translation (GO:0070129)3.55334381
59chromatin remodeling at centromere (GO:0031055)3.53942083
60negative regulation of ligase activity (GO:0051352)3.51969388
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51969388
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51158821
63kinetochore assembly (GO:0051382)3.51063318
64nuclear pore organization (GO:0006999)3.50082253
65establishment of integrated proviral latency (GO:0075713)3.49986425
66rRNA methylation (GO:0031167)3.49001879
67formation of translation preinitiation complex (GO:0001731)3.48183396
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47686468
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47686468
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47686468
71regulation of centriole replication (GO:0046599)3.47471081
72regulation of double-strand break repair via homologous recombination (GO:0010569)3.45032552
73cellular component biogenesis (GO:0044085)3.43900144
74RNA methylation (GO:0001510)3.42508203
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42075549
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.42075549
77transcription elongation from RNA polymerase I promoter (GO:0006362)3.41843515
78regulation of cellular amino acid metabolic process (GO:0006521)3.40748765
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.40386716
80nucleobase-containing small molecule interconversion (GO:0015949)3.40217386
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.38994535
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38812639
83DNA geometric change (GO:0032392)3.37968274
84translation (GO:0006412)3.37637018
85sister chromatid segregation (GO:0000819)3.36282642
86regulation of translational fidelity (GO:0006450)3.34654714
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.34256239
88translational initiation (GO:0006413)3.32114395
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31765798
90DNA topological change (GO:0006265)3.31526345
91dosage compensation (GO:0007549)3.31248498
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30912215
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30912215
94spliceosomal tri-snRNP complex assembly (GO:0000244)3.30143657
95protein localization to chromosome, centromeric region (GO:0071459)3.29873147
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.28646726
97RNA destabilization (GO:0050779)3.28061877
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25975211
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25904649
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25904649
101translational elongation (GO:0006414)3.24656171
102pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22985851
103tRNA methylation (GO:0030488)3.19997884
104kinetochore organization (GO:0051383)3.19017861
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16301947
106regulation of mammary gland epithelial cell proliferation (GO:0033599)3.16075449
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12738336
108L-methionine salvage (GO:0071267)3.11738338
109L-methionine biosynthetic process (GO:0071265)3.11738338
110amino acid salvage (GO:0043102)3.11738338
111positive regulation of ligase activity (GO:0051351)3.10360564
112cotranslational protein targeting to membrane (GO:0006613)3.10056482
113mitotic nuclear envelope disassembly (GO:0007077)3.08117217
114protein targeting to ER (GO:0045047)3.06666769
115pore complex assembly (GO:0046931)3.03014791
116G1/S transition of mitotic cell cycle (GO:0000082)3.02701804
117cell cycle G1/S phase transition (GO:0044843)3.02701804
118metaphase plate congression (GO:0051310)3.01769956
119DNA replication-independent nucleosome assembly (GO:0006336)3.01048951
120DNA replication-independent nucleosome organization (GO:0034724)3.01048951
121negative regulation of erythrocyte differentiation (GO:0045647)2.98783634
122folic acid-containing compound biosynthetic process (GO:0009396)2.96965264
123DNA conformation change (GO:0071103)2.96460994
124GDP-mannose metabolic process (GO:0019673)2.94201014
125pentose-phosphate shunt (GO:0006098)2.93008928
126rRNA transcription (GO:0009303)2.89361658
127membrane disassembly (GO:0030397)2.88930201
128nuclear envelope disassembly (GO:0051081)2.88930201
129heterochromatin organization (GO:0070828)2.88822168
130UV protection (GO:0009650)2.88682158
131regulation of translational termination (GO:0006449)2.88293574
132base-excision repair, AP site formation (GO:0006285)2.87116716
133chromosome condensation (GO:0030261)2.86990705
134pentose metabolic process (GO:0019321)2.85977173
135negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84514852
136proline biosynthetic process (GO:0006561)2.83887910
137mitotic sister chromatid cohesion (GO:0007064)2.83213017
138folic acid metabolic process (GO:0046655)2.78328831
139regulation of RNA export from nucleus (GO:0046831)2.76370376
140protein localization to kinetochore (GO:0034501)2.68847246
141chromatin assembly (GO:0031497)2.65995023
142pyrimidine nucleotide catabolic process (GO:0006244)2.65765114
143protein complex localization (GO:0031503)2.63825953
1443-UTR-mediated mRNA stabilization (GO:0070935)2.62179807
145DNA synthesis involved in DNA repair (GO:0000731)2.59900055
146mitochondrial DNA metabolic process (GO:0032042)2.59847618
147negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.58263651
148pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.56849010
149chaperone mediated protein folding requiring cofactor (GO:0051085)2.56813529
150regulation of nucleobase-containing compound transport (GO:0032239)2.56735055
151negative regulation of chromosome segregation (GO:0051985)2.55659923
152deoxyribonucleotide catabolic process (GO:0009264)2.54491560
153positive regulation of B cell differentiation (GO:0045579)2.54390658
154deoxyribose phosphate catabolic process (GO:0046386)2.54315749
155mitochondrial fusion (GO:0008053)2.53711297
156protein-DNA complex disassembly (GO:0032986)2.52340780
157nucleosome disassembly (GO:0006337)2.52340780
158nuclear envelope organization (GO:0006998)2.51836668
159urea cycle (GO:0000050)2.50642415
160histone H2B ubiquitination (GO:0033523)2.48044496
161apoptotic process involved in morphogenesis (GO:0060561)2.47905926
162NIK/NF-kappaB signaling (GO:0038061)2.46644665
163NADPH regeneration (GO:0006740)2.45008247
164snRNA metabolic process (GO:0016073)2.44784620
165negative regulation of DNA-templated transcription, elongation (GO:0032785)2.43905478
166DNA strand renaturation (GO:0000733)2.43563986
167mitotic spindle assembly checkpoint (GO:0007094)2.42159594
168purine deoxyribonucleotide catabolic process (GO:0009155)2.41804959
169chromatin assembly or disassembly (GO:0006333)2.41633131
170viral mRNA export from host cell nucleus (GO:0046784)2.41347285
171positive regulation of chromosome segregation (GO:0051984)2.41111836
172histone phosphorylation (GO:0016572)2.40668006
173pinocytosis (GO:0006907)2.40452479
174negative regulation of necroptotic process (GO:0060546)2.39104158
175negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.36506295
176negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.36506295
177negative regulation of mitotic sister chromatid segregation (GO:0033048)2.36506295
178negative regulation of mitotic sister chromatid separation (GO:2000816)2.36506295
179negative regulation of sister chromatid segregation (GO:0033046)2.36506295
180monoubiquitinated protein deubiquitination (GO:0035520)2.33859940
181spindle assembly checkpoint (GO:0071173)2.33815633
182meiotic chromosome segregation (GO:0045132)2.33377225
183regulation of histone H3-K27 methylation (GO:0061085)2.32870165
184DNA packaging (GO:0006323)2.32502518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.24463134
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.52958486
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52059021
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.02695651
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.88926600
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.82484364
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.72935160
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37776383
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24957331
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.22042769
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14708001
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10697952
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.10222509
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07540494
15MYC_22102868_ChIP-Seq_BL_Human3.02376872
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93108581
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75271083
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71149911
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69378514
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66810609
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.66500283
22VDR_23849224_ChIP-Seq_CD4+_Human2.64268985
23VDR_21846776_ChIP-Seq_THP-1_Human2.63536346
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63249284
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55325918
26XRN2_22483619_ChIP-Seq_HELA_Human2.47687445
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45381576
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39120633
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25765584
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.23004016
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22916632
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17119944
33EGR1_19374776_ChIP-ChIP_THP-1_Human2.13969941
34FOXP3_21729870_ChIP-Seq_TREG_Human2.11456701
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09509582
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09357296
37TTF2_22483619_ChIP-Seq_HELA_Human2.07439307
38DCP1A_22483619_ChIP-Seq_HELA_Human2.06892358
39NANOG_18555785_ChIP-Seq_MESCs_Mouse2.06482348
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.94514611
41GABP_19822575_ChIP-Seq_HepG2_Human1.92021417
42ELK1_19687146_ChIP-ChIP_HELA_Human1.89216084
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87709800
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86178274
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85182061
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76177399
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70464845
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68128596
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67198340
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64896219
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.64555021
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64295927
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57089084
54CIITA_25753668_ChIP-Seq_RAJI_Human1.55657714
55LXR_22292898_ChIP-Seq_THP-1_Human1.53388260
56ZNF263_19887448_ChIP-Seq_K562_Human1.51572029
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51497744
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49870184
59MAF_26560356_Chip-Seq_TH1_Human1.49565566
60* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48858058
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.46870642
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45932241
63* MAF_26560356_Chip-Seq_TH2_Human1.43505314
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41284347
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37799789
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.37301589
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.37169567
68RACK7_27058665_Chip-Seq_MCF-7_Human1.35129581
69AR_21909140_ChIP-Seq_LNCAP_Human1.34679315
70* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34475672
71TCF7_22412390_ChIP-Seq_EML_Mouse1.34464010
72UTX_26944678_Chip-Seq_JUKART_Human1.32540028
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.31914067
74* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30936385
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30620176
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30244043
77KDM2B_26808549_Chip-Seq_DND41_Human1.29170776
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28481612
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27881724
80* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27588703
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27245340
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26308234
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26308234
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26308234
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26227366
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25957048
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23369405
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21567766
89KDM5A_27292631_Chip-Seq_BREAST_Human1.21315768
90VDR_24763502_ChIP-Seq_THP-1_Human1.21269385
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.18129280
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17983209
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15237784
94P68_20966046_ChIP-Seq_HELA_Human1.14992924
95* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13751619
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13451231
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11986622
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11513525
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.11443729
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10477540
101NCOR1_26117541_ChIP-Seq_K562_Human1.10432992
102MYC_18940864_ChIP-ChIP_HL60_Human1.10179693
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09071782
104TP63_17297297_ChIP-ChIP_HaCaT_Human1.08468188
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06728158
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06121743
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06061766
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05843824
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04955094
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04562038
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03871767
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03636688
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03404676
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03367518
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02967643
116* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02415209
117ELF1_20517297_ChIP-Seq_JURKAT_Human1.02180348
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01931646
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01897791
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01856203
121SPI1_23547873_ChIP-Seq_NB4_Human1.01562707
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01141948
123ATF3_27146783_Chip-Seq_COLON_Human1.00192824
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00012614
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99880094
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99381026
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97854036
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97492021
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97490977
130* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91974025
131TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89726396
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88743971
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88319959
134CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87092486
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85141666
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84901112
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84888403
138SOX17_20123909_ChIP-Seq_XEN_Mouse0.84028908
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83574410
140SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83359896
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.82047290
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.80754210
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75517758
144TFEB_21752829_ChIP-Seq_HELA_Human0.75056628
145DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74062883
146* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73715504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.78519969
2MP0003111_abnormal_nucleus_morphology4.64644336
3MP0008058_abnormal_DNA_repair4.06858047
4MP0008057_abnormal_DNA_replication3.95930088
5MP0010094_abnormal_chromosome_stability3.93213451
6MP0004957_abnormal_blastocyst_morpholog3.85117621
7MP0003077_abnormal_cell_cycle3.64932522
8MP0003718_maternal_effect3.11354697
9MP0008932_abnormal_embryonic_tissue2.96933833
10MP0008877_abnormal_DNA_methylation2.95802511
11MP0008007_abnormal_cellular_replicative2.86979131
12MP0004185_abnormal_adipocyte_glucose2.73852397
13MP0003786_premature_aging2.68391460
14MP0005451_abnormal_body_composition2.62404815
15MP0003705_abnormal_hypodermis_morpholog2.55793077
16MP0009379_abnormal_foot_pigmentation2.50998498
17MP0001986_abnormal_taste_sensitivity2.44299731
18MP0002160_abnormal_reproductive_system2.27953353
19MP0006292_abnormal_olfactory_placode2.19508235
20MP0000566_synostosis2.16990859
21MP0003941_abnormal_skin_development1.95654053
22MP0005389_reproductive_system_phenotype1.91055956
23MP0005058_abnormal_lysosome_morphology1.90374754
24MP0009278_abnormal_bone_marrow1.88814713
25MP0004133_heterotaxia1.83885654
26MP0001188_hyperpigmentation1.83218463
27MP0005076_abnormal_cell_differentiation1.80123347
28MP0003806_abnormal_nucleotide_metabolis1.77830031
29MP0003315_abnormal_perineum_morphology1.73488633
30MP0001853_heart_inflammation1.64090812
31MP0005423_abnormal_somatic_nervous1.63012914
32MP0000537_abnormal_urethra_morphology1.62382608
33MP0002210_abnormal_sex_determination1.58786970
34MP0001730_embryonic_growth_arrest1.56804505
35MP0003123_paternal_imprinting1.56089256
36MP0005083_abnormal_biliary_tract1.54315198
37MP0000350_abnormal_cell_proliferation1.54047015
38MP0004808_abnormal_hematopoietic_stem1.53476809
39MP0001849_ear_inflammation1.53223547
40MP0001919_abnormal_reproductive_system1.52465910
41MP0002877_abnormal_melanocyte_morpholog1.48869090
42MP0002277_abnormal_respiratory_mucosa1.48687903
43MP0002398_abnormal_bone_marrow1.46908600
44MP0010307_abnormal_tumor_latency1.45293855
45MP0004947_skin_inflammation1.44570943
46MP0005666_abnormal_adipose_tissue1.43402528
47MP0004233_abnormal_muscle_weight1.42659176
48MP0003186_abnormal_redox_activity1.42423160
49MP0000313_abnormal_cell_death1.37293530
50MP0001145_abnormal_male_reproductive1.37002463
51MP0003453_abnormal_keratinocyte_physiol1.36971526
52MP0001873_stomach_inflammation1.34939140
53MP0005501_abnormal_skin_physiology1.34633308
54MP0002089_abnormal_postnatal_growth/wei1.31559841
55MP0001835_abnormal_antigen_presentation1.29706541
56MP0006035_abnormal_mitochondrial_morpho1.28939215
57MP0008260_abnormal_autophagy1.27280321
58MP0009840_abnormal_foam_cell1.26797454
59MP0001661_extended_life_span1.26693529
60MP0005377_hearing/vestibular/ear_phenot1.26216666
61MP0003878_abnormal_ear_physiology1.26216666
62MP0003303_peritoneal_inflammation1.23863795
63MP0001929_abnormal_gametogenesis1.19146847
64MP0000653_abnormal_sex_gland1.18536479
65MP0005397_hematopoietic_system_phenotyp1.17721452
66MP0001545_abnormal_hematopoietic_system1.17721452
67MP0003890_abnormal_embryonic-extraembry1.15848777
68MP0005000_abnormal_immune_tolerance1.12429699
69MP0004381_abnormal_hair_follicle1.11906318
70MP0003646_muscle_fatigue1.11795856
71MP0005395_other_phenotype1.10931411
72MP0002429_abnormal_blood_cell1.10912726
73MP0002132_abnormal_respiratory_system1.10677703
74MP0005380_embryogenesis_phenotype1.10068964
75MP0001672_abnormal_embryogenesis/_devel1.10068964
76MP0001697_abnormal_embryo_size1.09371180
77MP0002166_altered_tumor_susceptibility1.08772151
78MP0005075_abnormal_melanosome_morpholog1.08767253
79MP0010030_abnormal_orbit_morphology1.08561105
80MP0003136_yellow_coat_color1.07927709
81MP0002085_abnormal_embryonic_tissue1.07707324
82MP0002080_prenatal_lethality1.07311737
83MP0000685_abnormal_immune_system1.05826676
84MP0005464_abnormal_platelet_physiology1.04401745
85MP0002086_abnormal_extraembryonic_tissu1.03381757
86MP0000716_abnormal_immune_system1.03033223
87MP0002405_respiratory_system_inflammati1.01188265
88MP0003436_decreased_susceptibility_to1.00836980
89MP0000490_abnormal_crypts_of1.00258319
90MP0005623_abnormal_meninges_morphology0.99541767
91MP0002751_abnormal_autonomic_nervous0.99111709
92MP0002420_abnormal_adaptive_immunity0.98170867
93MP0003191_abnormal_cellular_cholesterol0.97241013
94MP0001819_abnormal_immune_cell0.96632353
95MP0002019_abnormal_tumor_incidence0.96367019
96MP0008789_abnormal_olfactory_epithelium0.96030857
97MP0009672_abnormal_birth_weight0.94637593
98MP0001119_abnormal_female_reproductive0.94462848
99MP0000613_abnormal_salivary_gland0.93487734
100MP0001348_abnormal_lacrimal_gland0.92799536
101MP0001800_abnormal_humoral_immune0.90257155
102MP0002723_abnormal_immune_serum0.89522721
103MP0000358_abnormal_cell_content/0.89029676
104MP0002796_impaired_skin_barrier0.89018405
105MP0008995_early_reproductive_senescence0.88193643
106MP0002452_abnormal_antigen_presenting0.86607346
107MP0003119_abnormal_digestive_system0.85636134
108MP0003566_abnormal_cell_adhesion0.85636128
109MP0002111_abnormal_tail_morphology0.85445284
110MP0000733_abnormal_muscle_development0.84955040
111MP0005384_cellular_phenotype0.84869516
112MP0002102_abnormal_ear_morphology0.84528336
113MP0005375_adipose_tissue_phenotype0.84321915
114MP0000015_abnormal_ear_pigmentation0.83853865
115MP0005025_abnormal_response_to0.82147349
116MP0003698_abnormal_male_reproductive0.82100008
117MP0002006_tumorigenesis0.81848396
118MP0001286_abnormal_eye_development0.81322400
119MP0001216_abnormal_epidermal_layer0.80618501
120MP0003984_embryonic_growth_retardation0.79463750
121MP0003567_abnormal_fetal_cardiomyocyte0.79246146
122MP0009333_abnormal_splenocyte_physiolog0.78951057
123MP0000703_abnormal_thymus_morphology0.78881393
124MP0002009_preneoplasia0.78783219
125MP0003936_abnormal_reproductive_system0.78537154
126MP0001529_abnormal_vocalization0.77393441
127MP0004197_abnormal_fetal_growth/weight/0.77132440
128MP0002148_abnormal_hypersensitivity_rea0.76715991
129MP0009931_abnormal_skin_appearance0.76610053
130MP0002088_abnormal_embryonic_growth/wei0.76566246
131MP0005409_darkened_coat_color0.76565465
132MP0002060_abnormal_skin_morphology0.76404826
133MP0003300_gastrointestinal_ulcer0.76349753
134MP0003121_genomic_imprinting0.75380641
135MP0005394_taste/olfaction_phenotype0.74525897
136MP0005499_abnormal_olfactory_system0.74525897
137MP0004142_abnormal_muscle_tone0.72942053
138MP0001293_anophthalmia0.72928151
139MP0005621_abnormal_cell_physiology0.72679973
140MP0003937_abnormal_limbs/digits/tail_de0.70867850
141MP0000049_abnormal_middle_ear0.70602610
142MP0005171_absent_coat_pigmentation0.68248082
143MP0003763_abnormal_thymus_physiology0.66645120
144MP0005670_abnormal_white_adipose0.64796208
145MP0005266_abnormal_metabolism0.64761373
146MP0010352_gastrointestinal_tract_polyps0.64151007
147MP0006036_abnormal_mitochondrial_physio0.64003030
148MP0002396_abnormal_hematopoietic_system0.63245571
149MP0003938_abnormal_ear_development0.63209398
150MP0000678_abnormal_parathyroid_gland0.62581556
151MP0001727_abnormal_embryo_implantation0.62562570
152MP0000372_irregular_coat_pigmentation0.61793387
153MP0001186_pigmentation_phenotype0.61304111
154MP0001764_abnormal_homeostasis0.60750807
155MP0002722_abnormal_immune_system0.59846690
156MP0002084_abnormal_developmental_patter0.59739938
157MP0000858_altered_metastatic_potential0.59021971
158MP0002638_abnormal_pupillary_reflex0.58872842
159MP0000689_abnormal_spleen_morphology0.57893786

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)5.71965870
2Breast hypoplasia (HP:0003187)5.34108971
3Birth length less than 3rd percentile (HP:0003561)5.02387275
4Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.98247707
5Cutaneous melanoma (HP:0012056)4.67359560
6Reticulocytopenia (HP:0001896)4.08660256
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.96272642
8Duplicated collecting system (HP:0000081)3.95463717
9Squamous cell carcinoma (HP:0002860)3.89816879
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.82204598
11Cerebral hypomyelination (HP:0006808)3.72977815
12Chromsome breakage (HP:0040012)3.58249387
13Carpal bone hypoplasia (HP:0001498)3.55481767
14Abnormality of the renal collecting system (HP:0004742)3.43085230
15Abnormality of cells of the erythroid lineage (HP:0012130)3.25298932
16Rough bone trabeculation (HP:0100670)3.22838159
17Abnormal number of erythroid precursors (HP:0012131)3.21765182
18Macrocytic anemia (HP:0001972)3.21230728
19Hyperacusis (HP:0010780)3.17944935
20Progressive muscle weakness (HP:0003323)3.14648351
21Patellar aplasia (HP:0006443)3.12861981
22Granulocytopenia (HP:0001913)3.11357472
23Aplasia/Hypoplasia of the patella (HP:0006498)3.02953461
24Stomach cancer (HP:0012126)3.02863383
25External ophthalmoplegia (HP:0000544)3.00739307
26Meckel diverticulum (HP:0002245)2.99369973
27Oral leukoplakia (HP:0002745)2.97895964
28Absent radius (HP:0003974)2.93601183
29Increased serum lactate (HP:0002151)2.89791056
30Ulnar bowing (HP:0003031)2.87677505
31Abnormality of the preputium (HP:0100587)2.83981118
32Abnormality of the ileum (HP:0001549)2.82223149
33Aplasia involving forearm bones (HP:0009822)2.80507156
34Absent forearm bone (HP:0003953)2.80507156
35Sparse lateral eyebrow (HP:0005338)2.76166485
36Proximal tubulopathy (HP:0000114)2.72733679
37Acute necrotizing encephalopathy (HP:0006965)2.65078676
38Absent thumb (HP:0009777)2.64550583
39Mitochondrial inheritance (HP:0001427)2.61457392
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.61446816
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59653968
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59653968
43Pallor (HP:0000980)2.56776313
44Aplasia/Hypoplasia involving the musculature (HP:0001460)2.56149936
45Exercise intolerance (HP:0003546)2.55808308
463-Methylglutaconic aciduria (HP:0003535)2.54778784
47Hepatocellular necrosis (HP:0001404)2.54490712
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54402321
49Abnormality of chromosome stability (HP:0003220)2.52899754
50Broad distal phalanx of finger (HP:0009836)2.51674521
51Microvesicular hepatic steatosis (HP:0001414)2.51621009
52Premature graying of hair (HP:0002216)2.50568434
53Horseshoe kidney (HP:0000085)2.44866816
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.44066438
55Acute lymphatic leukemia (HP:0006721)2.41846451
56Poikiloderma (HP:0001029)2.41574704
57Abnormal trabecular bone morphology (HP:0100671)2.38943810
58Increased CSF lactate (HP:0002490)2.38865779
59Increased hepatocellular lipid droplets (HP:0006565)2.37597708
60Aplastic anemia (HP:0001915)2.37131598
61Bone marrow hypocellularity (HP:0005528)2.36805053
62Ragged-red muscle fibers (HP:0003200)2.36401942
63Impulsivity (HP:0100710)2.35093957
64Vertebral compression fractures (HP:0002953)2.34819382
65Triphalangeal thumb (HP:0001199)2.32876451
66Microretrognathia (HP:0000308)2.30590644
67Neoplasm of the adrenal cortex (HP:0100641)2.29732214
68Aplasia/hypoplasia of the uterus (HP:0008684)2.29543269
69Secondary amenorrhea (HP:0000869)2.28715622
70Type I transferrin isoform profile (HP:0003642)2.28616917
71Insomnia (HP:0100785)2.26917351
72Trismus (HP:0000211)2.25582791
73Colon cancer (HP:0003003)2.25516333
74Abnormal mitochondria in muscle tissue (HP:0008316)2.22975604
75Hepatic necrosis (HP:0002605)2.22502629
76Biconcave vertebral bodies (HP:0004586)2.22375350
77Renal Fanconi syndrome (HP:0001994)2.21276824
78Neoplasm of the pancreas (HP:0002894)2.20760413
79Type 2 muscle fiber atrophy (HP:0003554)2.20757816
80Hypergonadotropic hypogonadism (HP:0000815)2.20633395
81Abnormality of the phalanges of the hallux (HP:0010057)2.18230042
82Ureteral duplication (HP:0000073)2.17040196
83Basal cell carcinoma (HP:0002671)2.16340168
84Thrombocytosis (HP:0001894)2.13638989
85Cellular immunodeficiency (HP:0005374)2.13167125
86Cleft eyelid (HP:0000625)2.13153792
87Premature ovarian failure (HP:0008209)2.12712124
88Abnormality of DNA repair (HP:0003254)2.12582655
89CNS hypomyelination (HP:0003429)2.12329120
90Intestinal fistula (HP:0100819)2.11740655
91Pancreatic cysts (HP:0001737)2.11572470
92Exertional dyspnea (HP:0002875)2.10460174
93Vaginal fistula (HP:0004320)2.10237700
94Short nail (HP:0001799)2.05965106
95Unsteady gait (HP:0002317)2.05547451
96Entropion (HP:0000621)2.04473126
97Myelodysplasia (HP:0002863)2.04198386
98Broad face (HP:0000283)2.03332458
99Supernumerary spleens (HP:0009799)2.03327938
100Muscle fiber atrophy (HP:0100295)2.02213575
101Long foot (HP:0001833)2.00061054
102Breast aplasia (HP:0100783)1.99793888
103Pancytopenia (HP:0001876)1.99365871
104Selective tooth agenesis (HP:0001592)1.99364689
105Glucose intolerance (HP:0000833)1.98230508
106Clubbing of toes (HP:0100760)1.98133251
107Degeneration of anterior horn cells (HP:0002398)1.97435980
108Abnormality of the anterior horn cell (HP:0006802)1.97435980
109Hypoplasia of the radius (HP:0002984)1.96813110
110Lactic acidosis (HP:0003128)1.96087437
111Sparse eyelashes (HP:0000653)1.95647423
112Megaloblastic anemia (HP:0001889)1.95174508
113Progressive macrocephaly (HP:0004481)1.95082791
114Duplication of thumb phalanx (HP:0009942)1.94945930
115Aplasia/Hypoplasia of the breasts (HP:0010311)1.94574835
116Spina bifida occulta (HP:0003298)1.93778016
117Testicular atrophy (HP:0000029)1.93040831
118Acute encephalopathy (HP:0006846)1.92166674
119Overriding aorta (HP:0002623)1.90336945
120Small intestinal stenosis (HP:0012848)1.88976682
121Duodenal stenosis (HP:0100867)1.88976682
122Lipid accumulation in hepatocytes (HP:0006561)1.88340682
123Abnormal spermatogenesis (HP:0008669)1.88300831
124Rectovaginal fistula (HP:0000143)1.87359540
125Rectal fistula (HP:0100590)1.87359540
126Achilles tendon contracture (HP:0001771)1.87086940
127Tracheoesophageal fistula (HP:0002575)1.86165493
128Myopathic facies (HP:0002058)1.85276600
129Deep palmar crease (HP:0006191)1.84789025
130IgM deficiency (HP:0002850)1.84360219
131Abnormality of abdominal situs (HP:0011620)1.84230832
132Long palpebral fissure (HP:0000637)1.84010921
133Thin bony cortex (HP:0002753)1.81600136
134Abnormality of subcutaneous fat tissue (HP:0001001)1.80472486
135Short thumb (HP:0009778)1.80194722
136Bowing of the arm (HP:0006488)1.79414948
137Bowed forearm bones (HP:0003956)1.79414948
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.77332271
139Prominent nose (HP:0000448)1.75877339
140Proximal placement of thumb (HP:0009623)1.75306420
141Deviation of the thumb (HP:0009603)1.74823529
142Increased nuchal translucency (HP:0010880)1.73747883
143Cellulitis (HP:0100658)1.72821707
144High anterior hairline (HP:0009890)1.72629594
145Persistence of primary teeth (HP:0006335)1.72477168
146Long eyelashes (HP:0000527)1.72446042
147Fatigue (HP:0012378)1.72325672
148Rectal prolapse (HP:0002035)1.71776425
149Colitis (HP:0002583)1.70905507
150Melanoma (HP:0002861)1.70603335
151Acute hepatic failure (HP:0006554)1.70592130
152Rib fusion (HP:0000902)1.70248336
153Petechiae (HP:0000967)1.68201935
154Recurrent viral infections (HP:0004429)1.67969563
155Abnormality of the distal phalanges of the toes (HP:0010182)1.67362239
156Ectopic kidney (HP:0000086)1.67127717
157Abnormality of the fingertips (HP:0001211)1.66290853
15811 pairs of ribs (HP:0000878)1.63108360
159Cafe-au-lait spot (HP:0000957)1.61651912
160Abnormality of cochlea (HP:0000375)1.60393251
161Abnormality of pyrimidine metabolism (HP:0004353)1.58059835
162Easy fatigability (HP:0003388)1.57212843
163Asymmetry of the thorax (HP:0001555)1.55648220
164Abnormality of cells of the lymphoid lineage (HP:0012140)1.55463071
165Flattened epiphyses (HP:0003071)1.55460148
166Flat occiput (HP:0005469)1.55280650
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.54966007
168Abnormality of the umbilical cord (HP:0010881)1.54724433
169Renal duplication (HP:0000075)1.54297428
170Abnormality of the carotid arteries (HP:0005344)1.53434663
171Abnormalities of placenta or umbilical cord (HP:0001194)1.52994597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.91425267
2PLK45.31173637
3BUB15.01118437
4ZAK3.86049094
5STK163.70305804
6MARK13.64055203
7TRIB33.47117813
8SMG13.38489543
9CDK123.36147247
10IRAK43.05332595
11WEE13.02648106
12EIF2AK12.60022925
13IRAK22.59321647
14SRPK12.32098600
15MAP3K132.29450582
16TTK2.26770472
17IRAK12.11492327
18TSSK62.06888623
19EPHA22.04203669
20TESK21.99526844
21EIF2AK31.92478762
22EEF2K1.90142612
23ICK1.84305451
24MAP3K101.75202873
25CDC71.72869083
26MAP2K31.68152885
27VRK21.67709930
28VRK11.65290493
29MAP4K11.54694489
30TLK11.53222458
31PNCK1.51090874
32SCYL21.48733280
33SIK11.47015261
34PRPF4B1.45556859
35CDK41.44373003
36PLK11.44338280
37PLK31.43721906
38ERN11.39512521
39DYRK31.32467951
40MAP3K141.23570276
41MUSK1.21774963
42CDK81.21158264
43NME11.21086234
44AKT31.16281207
45CAMK1D1.05680256
46RPS6KB21.02739542
47KDR0.98741734
48CHEK20.98647159
49MKNK10.98524841
50PBK0.97894249
51NME20.96254363
52TAF10.95904648
53PRKCI0.95689901
54AURKA0.94880705
55TTN0.94802256
56EIF2AK20.93190741
57MST1R0.92954506
58STK38L0.91695638
59CAMK1G0.90723190
60RIPK10.90424487
61BRSK20.90164409
62MKNK20.88711477
63MELK0.87856915
64BMX0.87041787
65PAK40.85761574
66* ATR0.84402048
67AURKB0.83721977
68MTOR0.83491250
69TESK10.82533242
70BRAF0.82462395
71DYRK20.82118741
72ACVR1B0.79988479
73MAPK110.78383453
74CDK90.74907845
75NEK20.72563050
76GRK60.71492991
77CDK70.68551514
78TAOK10.66706666
79MAP2K20.66441154
80IKBKE0.66037798
81MAPKAPK30.65738472
82BTK0.64447025
83MAP3K110.64312292
84RIPK40.63656244
85CHEK10.63547388
86NEK10.62650612
87PDGFRA0.61698494
88BRD40.61441049
89TBK10.60515733
90BRSK10.58156567
91ABL20.57962979
92FGFR40.57961403
93LRRK20.57046647
94CDC42BPA0.56064629
95NEK60.55791568
96ZAP700.55441524
97RPS6KC10.55169438
98RPS6KL10.55169438
99MAP3K80.54759595
100PIM20.54142101
101PKN20.54059925
102LATS20.54018635
103STK40.53037310
104PRKD20.52759126
105LIMK10.52027841
106BLK0.51405313
107CDK60.51374690
108JAK30.51262026
109SIK30.51040245
110PASK0.50950890
111TNIK0.50198280
112CSK0.50017059
113CCNB10.49269500
114CSNK2A10.49166292
115PAK10.47150031
116PDK20.47050072
117ATM0.46414813
118CSNK2A20.45264702
119RPS6KA50.42426741
120CAMK2B0.41793029
121TYRO30.38562076
122RPS6KA60.38267000
123BCKDK0.37372318
124RPS6KA20.37092131
125* CDK20.35150930
126CAMK2G0.34373835
127PLK20.32725733
128CDK10.32657638
129CAMK2D0.31487998
130MST40.28751069
131CSNK1E0.28550221
132PINK10.27252035
133MAPK70.26700218
134IKBKB0.24276428
135TAOK20.22321933
136MAPK40.22046176
137RPS6KA40.20265483
138YES10.18451095
139PRKDC0.17517023
140TEC0.17249325
141NLK0.14714722
142CDK190.14618975
143CLK10.14333314
144ADRBK20.10543380
145ROCK20.10317476
146PIM10.09972009
147GRK10.09720192
148TXK0.09246370
149MAPK90.09045960
150STK100.08012808
151BMPR20.07900342
152BMPR1B0.05604365

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.50822729
2Proteasome_Homo sapiens_hsa030504.50262367
3RNA polymerase_Homo sapiens_hsa030204.46693351
4Ribosome_Homo sapiens_hsa030104.27710270
5Mismatch repair_Homo sapiens_hsa034303.82706176
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56985917
7Spliceosome_Homo sapiens_hsa030403.13532515
8Pyrimidine metabolism_Homo sapiens_hsa002403.12462932
9Homologous recombination_Homo sapiens_hsa034402.89367855
10Nucleotide excision repair_Homo sapiens_hsa034202.57798298
11RNA transport_Homo sapiens_hsa030132.54784013
12Base excision repair_Homo sapiens_hsa034102.43975719
13* Fanconi anemia pathway_Homo sapiens_hsa034602.32315789
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24582855
15One carbon pool by folate_Homo sapiens_hsa006702.15785086
16Oxidative phosphorylation_Homo sapiens_hsa001902.03191790
17Basal transcription factors_Homo sapiens_hsa030221.97410264
18Cell cycle_Homo sapiens_hsa041101.93134525
19Purine metabolism_Homo sapiens_hsa002301.82994902
20Parkinsons disease_Homo sapiens_hsa050121.73990964
21Huntingtons disease_Homo sapiens_hsa050161.72999986
22RNA degradation_Homo sapiens_hsa030181.72307159
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70026210
24Non-homologous end-joining_Homo sapiens_hsa034501.61641110
25p53 signaling pathway_Homo sapiens_hsa041151.55299415
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47519071
27Chronic myeloid leukemia_Homo sapiens_hsa052201.45668229
28Acute myeloid leukemia_Homo sapiens_hsa052211.34389815
29Bladder cancer_Homo sapiens_hsa052191.34010711
30Epstein-Barr virus infection_Homo sapiens_hsa051691.33469169
31Protein export_Homo sapiens_hsa030601.26809241
32Non-small cell lung cancer_Homo sapiens_hsa052231.25686172
33B cell receptor signaling pathway_Homo sapiens_hsa046621.23837546
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17247506
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13534476
36Pancreatic cancer_Homo sapiens_hsa052121.13171826
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12488324
38Glutathione metabolism_Homo sapiens_hsa004801.04136547
39Alzheimers disease_Homo sapiens_hsa050101.03981940
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.01999310
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01815389
42Small cell lung cancer_Homo sapiens_hsa052221.01698503
43mRNA surveillance pathway_Homo sapiens_hsa030151.01356523
44Folate biosynthesis_Homo sapiens_hsa007901.00609004
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00021773
46Hepatitis B_Homo sapiens_hsa051610.97119914
47Influenza A_Homo sapiens_hsa051640.90571727
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90168182
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89953127
50Viral myocarditis_Homo sapiens_hsa054160.84890810
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83741435
52Notch signaling pathway_Homo sapiens_hsa043300.80784888
53Leishmaniasis_Homo sapiens_hsa051400.79522201
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78890150
55Lysine degradation_Homo sapiens_hsa003100.78168010
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77460458
57MicroRNAs in cancer_Homo sapiens_hsa052060.77356730
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.76515212
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75143138
60Prostate cancer_Homo sapiens_hsa052150.74242163
61Vitamin B6 metabolism_Homo sapiens_hsa007500.73997508
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73525015
63Osteoclast differentiation_Homo sapiens_hsa043800.73409566
64Phototransduction_Homo sapiens_hsa047440.73303265
65VEGF signaling pathway_Homo sapiens_hsa043700.71348925
66Systemic lupus erythematosus_Homo sapiens_hsa053220.68868806
67Pentose phosphate pathway_Homo sapiens_hsa000300.68801604
68Hepatitis C_Homo sapiens_hsa051600.68029208
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67113874
70Colorectal cancer_Homo sapiens_hsa052100.65981297
71Toxoplasmosis_Homo sapiens_hsa051450.63846432
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62676090
73Pyruvate metabolism_Homo sapiens_hsa006200.62275099
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.61614792
75mTOR signaling pathway_Homo sapiens_hsa041500.60874144
76Arachidonic acid metabolism_Homo sapiens_hsa005900.60076599
77Oocyte meiosis_Homo sapiens_hsa041140.59896191
78TNF signaling pathway_Homo sapiens_hsa046680.59673196
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59356969
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.58713410
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57846288
82Metabolic pathways_Homo sapiens_hsa011000.57540530
83T cell receptor signaling pathway_Homo sapiens_hsa046600.56814341
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.55803307
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55441500
86Endometrial cancer_Homo sapiens_hsa052130.55264655
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55026847
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50733325
89Regulation of autophagy_Homo sapiens_hsa041400.48691122
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.48680000
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48076108
92Sulfur relay system_Homo sapiens_hsa041220.46142605
93FoxO signaling pathway_Homo sapiens_hsa040680.44419069
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44189302
95Viral carcinogenesis_Homo sapiens_hsa052030.43966201
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43614694
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43260678
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.43127914
99Other glycan degradation_Homo sapiens_hsa005110.41891285
100Linoleic acid metabolism_Homo sapiens_hsa005910.41512484
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40701775
102Herpes simplex infection_Homo sapiens_hsa051680.40444048
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39854947
104Biosynthesis of amino acids_Homo sapiens_hsa012300.39203181
105Insulin signaling pathway_Homo sapiens_hsa049100.37879512
106Cardiac muscle contraction_Homo sapiens_hsa042600.37036149
107Phenylalanine metabolism_Homo sapiens_hsa003600.36332734
108Fructose and mannose metabolism_Homo sapiens_hsa000510.34156894
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33210035
110Arginine and proline metabolism_Homo sapiens_hsa003300.32968833
111Sphingolipid metabolism_Homo sapiens_hsa006000.32308447
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31276591
113HTLV-I infection_Homo sapiens_hsa051660.30285257
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.27793177
115Primary immunodeficiency_Homo sapiens_hsa053400.23009344
116Antigen processing and presentation_Homo sapiens_hsa046120.22925835
117Tyrosine metabolism_Homo sapiens_hsa003500.20639663
118Selenocompound metabolism_Homo sapiens_hsa004500.20534095
119Galactose metabolism_Homo sapiens_hsa000520.20334856
120Renin-angiotensin system_Homo sapiens_hsa046140.18812945
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18590974
122N-Glycan biosynthesis_Homo sapiens_hsa005100.16392948
123Collecting duct acid secretion_Homo sapiens_hsa049660.14553051
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14024907
125Autoimmune thyroid disease_Homo sapiens_hsa053200.13451507
126Carbon metabolism_Homo sapiens_hsa012000.13250535
127Alcoholism_Homo sapiens_hsa050340.13119687
128Ether lipid metabolism_Homo sapiens_hsa005650.12341088
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11628260
130Graft-versus-host disease_Homo sapiens_hsa053320.09468955
131Vibrio cholerae infection_Homo sapiens_hsa051100.09382588
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09269381
133Apoptosis_Homo sapiens_hsa042100.08259596
134Shigellosis_Homo sapiens_hsa051310.08084091
135Measles_Homo sapiens_hsa051620.07988407
136Asthma_Homo sapiens_hsa053100.06943910
137Allograft rejection_Homo sapiens_hsa053300.05477246
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.05315645
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04202784
140beta-Alanine metabolism_Homo sapiens_hsa004100.03191277
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.00470106
142Legionellosis_Homo sapiens_hsa051340.00089445
143Retinol metabolism_Homo sapiens_hsa00830-2.1373703
144Hippo signaling pathway_Homo sapiens_hsa04390-0.0085135
145Thyroid cancer_Homo sapiens_hsa05216-0.0023244

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