ATRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)4.91727739
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.72697785
3locomotory exploration behavior (GO:0035641)4.59139959
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.44874544
5regulation of fibrinolysis (GO:0051917)4.42934249
6synaptic vesicle maturation (GO:0016188)4.26452680
7vocalization behavior (GO:0071625)4.25975430
8neuron cell-cell adhesion (GO:0007158)4.25108141
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.07897549
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.07687125
11peptidyl-glutamic acid carboxylation (GO:0017187)4.01472780
12protein carboxylation (GO:0018214)4.01472780
13synaptic vesicle exocytosis (GO:0016079)3.98444519
14ionotropic glutamate receptor signaling pathway (GO:0035235)3.96919672
15central nervous system myelination (GO:0022010)3.91723265
16axon ensheathment in central nervous system (GO:0032291)3.91723265
17very-low-density lipoprotein particle assembly (GO:0034379)3.90481890
18protein localization to synapse (GO:0035418)3.88177354
19regulation of protein activation cascade (GO:2000257)3.84110492
20glutamate secretion (GO:0014047)3.80924674
21dendritic spine morphogenesis (GO:0060997)3.80430679
22neuronal action potential propagation (GO:0019227)3.78405682
23regulation of complement activation (GO:0030449)3.73326687
24regulation of glutamate receptor signaling pathway (GO:1900449)3.71724433
25hemidesmosome assembly (GO:0031581)3.71699087
26regulation of synaptic vesicle exocytosis (GO:2000300)3.69720610
27cell adhesion mediated by integrin (GO:0033627)3.66459062
28glutamate receptor signaling pathway (GO:0007215)3.65715007
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63357205
30exploration behavior (GO:0035640)3.61901987
31regulation of apoptotic cell clearance (GO:2000425)3.61890473
32gamma-aminobutyric acid transport (GO:0015812)3.61604804
33presynaptic membrane assembly (GO:0097105)3.60400909
34regulation of neuronal synaptic plasticity (GO:0048168)3.58102993
35neuron recognition (GO:0008038)3.53125642
36plasma lipoprotein particle assembly (GO:0034377)3.51998119
37transmission of nerve impulse (GO:0019226)3.47043721
38presynaptic membrane organization (GO:0097090)3.46012933
39synaptic transmission, glutamatergic (GO:0035249)3.44730268
40protein-lipid complex assembly (GO:0065005)3.43838379
41complement activation, alternative pathway (GO:0006957)3.43268562
42regulation of plasminogen activation (GO:0010755)3.38666119
43neuron-neuron synaptic transmission (GO:0007270)3.37474259
44regulation of cholesterol homeostasis (GO:2000188)3.34896506
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.34593907
46COPI coating of Golgi vesicle (GO:0048205)3.32210937
47Golgi transport vesicle coating (GO:0048200)3.32210937
48neurotransmitter-gated ion channel clustering (GO:0072578)3.28549972
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27614719
50neurotransmitter secretion (GO:0007269)3.27076325
51layer formation in cerebral cortex (GO:0021819)3.26355035
52L-amino acid import (GO:0043092)3.25731581
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.24813608
54axonal fasciculation (GO:0007413)3.24596949
55protein retention in ER lumen (GO:0006621)3.24042590
56skin morphogenesis (GO:0043589)3.21502278
57regulation of dendritic spine morphogenesis (GO:0061001)3.19509023
58cholesterol efflux (GO:0033344)3.17341610
59regulation of synaptic vesicle transport (GO:1902803)3.17298660
60regulation of cholesterol esterification (GO:0010872)3.16781627
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.14996610
62dendrite morphogenesis (GO:0048813)3.11278302
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.11039621
64long-term memory (GO:0007616)3.10213781
65basement membrane organization (GO:0071711)3.08978314
66regulation of postsynaptic membrane potential (GO:0060078)3.08090531
67positive regulation of extracellular matrix organization (GO:1903055)3.08072175
68synaptic vesicle docking involved in exocytosis (GO:0016081)3.07448269
69regulation of synapse structural plasticity (GO:0051823)3.06197830
70neuronal ion channel clustering (GO:0045161)3.05407125
71fibrinolysis (GO:0042730)3.04708312
72negative regulation of neurotransmitter transport (GO:0051589)3.02777219
73negative regulation of fatty acid transport (GO:2000192)3.01989001
74negative regulation of cholesterol transport (GO:0032375)3.01650739
75negative regulation of sterol transport (GO:0032372)3.01650739
76positive regulation of membrane potential (GO:0045838)2.98555257
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96953644
78auditory behavior (GO:0031223)2.96422566
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94904153
80regulation of cholesterol biosynthetic process (GO:0045540)2.93688808
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93144544
82behavioral response to cocaine (GO:0048148)2.91679661
83intestinal cholesterol absorption (GO:0030299)2.90369175
84protein-lipid complex remodeling (GO:0034368)2.89344153
85macromolecular complex remodeling (GO:0034367)2.89344153
86plasma lipoprotein particle remodeling (GO:0034369)2.89344153
87regulation of synaptic plasticity (GO:0048167)2.88909754
88protein localization to endosome (GO:0036010)2.88437144
89long-term synaptic potentiation (GO:0060291)2.88297234
90regulation of dendritic spine development (GO:0060998)2.86694343
91cellular potassium ion homeostasis (GO:0030007)2.86646570
92negative regulation of lipid transport (GO:0032369)2.85816415
93neurotransmitter transport (GO:0006836)2.85663125
94regulation of synaptic transmission, glutamatergic (GO:0051966)2.85274922
95low-density lipoprotein particle remodeling (GO:0034374)2.84110468
96cell-substrate junction assembly (GO:0007044)2.83194985
97adult walking behavior (GO:0007628)2.81975340
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81344473
99mating behavior (GO:0007617)2.80729371
100cerebellar granule cell differentiation (GO:0021707)2.80572760
101nerve growth factor signaling pathway (GO:0038180)2.78642289
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78634738
103neuromuscular process controlling balance (GO:0050885)2.76878418
104phospholipid efflux (GO:0033700)2.76829124
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76749678
106proline transport (GO:0015824)2.76689073
107desmosome organization (GO:0002934)2.74162858
108fatty acid elongation (GO:0030497)2.72566990
109endodermal cell differentiation (GO:0035987)2.72403478
110glycine transport (GO:0015816)2.71359492
111plasma lipoprotein particle clearance (GO:0034381)2.70971928
112postsynaptic membrane organization (GO:0001941)2.70873618
113embryonic retina morphogenesis in camera-type eye (GO:0060059)2.68877344
114long-chain fatty acid biosynthetic process (GO:0042759)2.68680761
115membrane hyperpolarization (GO:0060081)2.68225704
116dicarboxylic acid biosynthetic process (GO:0043650)2.67571694
117dendritic spine organization (GO:0097061)2.67360922
118regulation of neurotransmitter levels (GO:0001505)2.67066471
119blood coagulation, intrinsic pathway (GO:0007597)2.66727460
120protein-lipid complex subunit organization (GO:0071825)2.66506753
121response to auditory stimulus (GO:0010996)2.66429858
122negative regulation of neurotransmitter secretion (GO:0046929)2.66412542
123positive regulation of blood coagulation (GO:0030194)2.65842230
124positive regulation of hemostasis (GO:1900048)2.65842230
125plasma lipoprotein particle organization (GO:0071827)2.65729095
126positive regulation of dendritic spine development (GO:0060999)2.65579757
127cellular response to prostaglandin stimulus (GO:0071379)2.63623480
128regulation of neurotransmitter secretion (GO:0046928)2.63096653
129* myelination (GO:0042552)2.62846597
130response to histamine (GO:0034776)2.62643276
131regulation of vesicle fusion (GO:0031338)2.62518968
132membrane depolarization (GO:0051899)2.60245319
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59948878
134learning (GO:0007612)2.59250741
135activation of protein kinase A activity (GO:0034199)2.58712033
136regulation of glutamate secretion (GO:0014048)2.58700349
137synaptic vesicle endocytosis (GO:0048488)2.58327510
138negative regulation of blood coagulation (GO:0030195)2.58000193
139negative regulation of hemostasis (GO:1900047)2.58000193
140synapse assembly (GO:0007416)2.57991786
141* ensheathment of neurons (GO:0007272)2.57986383
142* axon ensheathment (GO:0008366)2.57986383
143positive regulation of coagulation (GO:0050820)2.56815904
144regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.56210526
145low-density lipoprotein particle clearance (GO:0034383)2.55941272
146COPII vesicle coating (GO:0048208)2.55378553
147regulation of extracellular matrix organization (GO:1903053)2.55134416
148insulin-like growth factor receptor signaling pathway (GO:0048009)2.54574465
149high-density lipoprotein particle remodeling (GO:0034375)2.54516879
150synapse organization (GO:0050808)2.54445765
151prepulse inhibition (GO:0060134)2.53918210
152regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53236140
153mechanosensory behavior (GO:0007638)2.53165402
154retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52820048
155triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.51931166
156sodium ion export (GO:0071436)2.51377082
157cerebellar Purkinje cell differentiation (GO:0021702)2.51249625
158neuron remodeling (GO:0016322)2.50763296
159behavioral fear response (GO:0001662)2.50753878
160behavioral defense response (GO:0002209)2.50753878
161regulation of extracellular matrix disassembly (GO:0010715)2.50468413
162apoptotic cell clearance (GO:0043277)2.49955304
163regulation of voltage-gated calcium channel activity (GO:1901385)2.49877002
164negative regulation of lipase activity (GO:0060192)2.49330848
165establishment of mitochondrion localization (GO:0051654)2.47831879
166urea metabolic process (GO:0019627)2.46956407
167negative regulation of wound healing (GO:0061045)2.45368435
168alpha-linolenic acid metabolic process (GO:0036109)2.44213594
169reverse cholesterol transport (GO:0043691)2.41803834
170negative regulation of coagulation (GO:0050819)2.39181533
171lipoprotein metabolic process (GO:0042157)2.38261249
172positive regulation of steroid metabolic process (GO:0045940)2.37790154
173negative regulation of protein activation cascade (GO:2000258)2.37431455
174glutamate metabolic process (GO:0006536)2.36529199
175regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.36298662
176urea cycle (GO:0000050)2.34929435
177regulation of early endosome to late endosome transport (GO:2000641)2.34805040
178regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34333803
179vesicle coating (GO:0006901)2.33652016
180regulation of bile acid biosynthetic process (GO:0070857)2.32699919
181intestinal absorption (GO:0050892)2.32446857
182L-phenylalanine metabolic process (GO:0006558)2.31531995
183erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.31531995
184positive regulation of triglyceride lipase activity (GO:0061365)2.31250237
185positive regulation of lipoprotein lipase activity (GO:0051006)2.31250237
186chondrocyte proliferation (GO:0035988)2.30972471
187adherens junction assembly (GO:0034333)2.29357761
188semaphorin-plexin signaling pathway (GO:0071526)2.25539441
189positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.25164596
190epithelial cell-cell adhesion (GO:0090136)2.24708406
191focal adhesion assembly (GO:0048041)2.24335346
192cell-substrate adherens junction assembly (GO:0007045)2.24335346
193regulation of cholesterol metabolic process (GO:0090181)2.23473442
194fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.23427809
195platelet degranulation (GO:0002576)2.22862500
196cell-cell junction maintenance (GO:0045217)2.22853115
197barbed-end actin filament capping (GO:0051016)2.21117709
198acute-phase response (GO:0006953)2.20692102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.72351258
2EZH2_22144423_ChIP-Seq_EOC_Human4.66435618
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.90282003
4GBX2_23144817_ChIP-Seq_PC3_Human3.50340314
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.93155833
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.86370771
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84959736
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83101582
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75726888
10CLOCK_20551151_ChIP-Seq_293T_Human2.72805128
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56147209
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52647010
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47070215
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47070215
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41487288
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.38738650
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.36202910
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35398674
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33153192
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27998431
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27606951
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26042420
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.25343386
24DROSHA_22980978_ChIP-Seq_HELA_Human2.23923375
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.14625901
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.13644037
27* LXR_22158963_ChIP-Seq_LIVER_Mouse2.09589173
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.07856115
29* FOXA2_19822575_ChIP-Seq_HepG2_Human2.04328704
30REST_21632747_ChIP-Seq_MESCs_Mouse2.03271545
31TAF15_26573619_Chip-Seq_HEK293_Human2.01183266
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.00997317
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00142544
34AR_21572438_ChIP-Seq_LNCaP_Human1.98857330
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97583495
36ZNF263_19887448_ChIP-Seq_K562_Human1.95895100
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.95548460
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.94539408
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88410744
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85575361
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83447853
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76203328
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.73856835
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72512723
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70425173
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65721818
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64955119
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63214155
49KDM2B_26808549_Chip-Seq_K562_Human1.61657633
50SMAD4_21799915_ChIP-Seq_A2780_Human1.60574957
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59206928
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58636259
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.57875639
54* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56335576
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55505744
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53592878
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52375308
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50358058
59LXR_22292898_ChIP-Seq_THP-1_Human1.48992545
60P300_19829295_ChIP-Seq_ESCs_Human1.48884981
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47909631
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46000626
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.45962983
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44981548
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.43981602
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43172298
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43108769
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41102913
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40337093
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.39977568
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39781029
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39732556
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39177649
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36492981
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36260227
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35809427
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35428368
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34754026
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34635780
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33243926
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32160218
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31824247
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31013996
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30870687
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30179329
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29964456
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.29828396
88STAT3_23295773_ChIP-Seq_U87_Human1.29519036
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.29152567
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28916389
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28809715
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28315454
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.27625270
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.27625270
95RACK7_27058665_Chip-Seq_MCF-7_Human1.27064804
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26898420
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.26774957
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26717669
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25960292
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.24741714
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24664129
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.23778064
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.23708046
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23355496
105TP53_16413492_ChIP-PET_HCT116_Human1.23277550
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22346080
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22093720
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21407044
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20182461
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.19500252
111AR_25329375_ChIP-Seq_VCAP_Human1.18404298
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.18372201
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17277068
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.16834754
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15986718
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14925944
117ERG_21242973_ChIP-ChIP_JURKAT_Human1.14738492
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14009644
119ER_23166858_ChIP-Seq_MCF-7_Human1.13928710
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13866280
121AHR_22903824_ChIP-Seq_MCF-7_Human1.13789814
122TCF4_23295773_ChIP-Seq_U87_Human1.13448648
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.13064509
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12323348
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12241425
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11580931
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10974432
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.10635002
129* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10393110
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.09990690
131FUS_26573619_Chip-Seq_HEK293_Human1.09986295
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08924974
133ZNF274_21170338_ChIP-Seq_K562_Hela1.08772343
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07520560
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07399313
136* AR_19668381_ChIP-Seq_PC3_Human1.07112189
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05966922
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05785493
139UBF1/2_26484160_Chip-Seq_HMECs_Human1.05317760
140BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03942609
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03676270
142NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03676270
143P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03646160
144* RUNX2_22187159_ChIP-Seq_PCA_Human1.03020541
145TCF4_18268006_ChIP-ChIP_LS174T_Human1.02081695
146TP53_18474530_ChIP-ChIP_U2OS_Human1.01977218
147PRDM14_20953172_ChIP-Seq_ESCs_Human1.01890595
148* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01694348
149SOX2_20726797_ChIP-Seq_SW620_Human1.00584268
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00526618
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99765556
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99765556
153* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99622766
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99579006
155TP53_22127205_ChIP-Seq_IMR90_Human0.99115196
156* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98186176
157RING1B_27294783_Chip-Seq_NPCs_Mouse0.97690198
158ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97598015
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.96584970
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96093092
161IGF1R_20145208_ChIP-Seq_DFB_Human0.95386092
162EP300_21415370_ChIP-Seq_HL-1_Mouse0.94505606
163TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94421933
164YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94382109
165* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94110733
166BCAT_22108803_ChIP-Seq_LS180_Human0.93604344
167VDR_22108803_ChIP-Seq_LS180_Human0.93568529
168STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92965430
169TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92546098
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92131571
171POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92131571
172* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91427060
173SMAD3_21741376_ChIP-Seq_HESCs_Human0.90797646
174TCF7_22412390_ChIP-Seq_EML_Mouse0.89502638
175BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89383443
176RNF2_27304074_Chip-Seq_NSC_Mouse0.88769805
177TET1_21490601_ChIP-Seq_MESCs_Mouse0.88486168
178CJUN_26792858_Chip-Seq_BT549_Human0.88096307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.74790346
2MP0003880_abnormal_central_pattern4.70131080
3MP0008438_abnormal_cutaneous_collagen4.31466977
4MP0004270_analgesia3.77238990
5MP0003635_abnormal_synaptic_transmissio3.72129074
6MP0003705_abnormal_hypodermis_morpholog3.71615077
7MP0009745_abnormal_behavioral_response3.20951279
8MP0004272_abnormal_basement_membrane3.17042057
9MP0002063_abnormal_learning/memory/cond3.00377518
10* MP0002064_seizures3.00365302
11MP0009046_muscle_twitch2.80904458
12MP0001486_abnormal_startle_reflex2.76664057
13MP0003566_abnormal_cell_adhesion2.72368803
14MP0005257_abnormal_intraocular_pressure2.71650027
15MP0005058_abnormal_lysosome_morphology2.70217070
16MP0002272_abnormal_nervous_system2.64867791
17MP0002822_catalepsy2.61444641
18MP0002572_abnormal_emotion/affect_behav2.59375862
19MP0010368_abnormal_lymphatic_system2.58026729
20MP0005365_abnormal_bile_salt2.56606898
21MP0003329_amyloid_beta_deposits2.50900237
22MP0005423_abnormal_somatic_nervous2.49761169
23MP0001968_abnormal_touch/_nociception2.47442856
24MP0009840_abnormal_foam_cell2.39127382
25MP0002734_abnormal_mechanical_nocicepti2.32226427
26* MP0000920_abnormal_myelination2.12763738
27MP0005275_abnormal_skin_tensile2.11119024
28MP0001440_abnormal_grooming_behavior2.07748734
29MP0009780_abnormal_chondrocyte_physiolo2.03275834
30MP0001501_abnormal_sleep_pattern2.01046709
31MP0002735_abnormal_chemical_nociception2.00218261
32MP0000778_abnormal_nervous_system1.98663976
33MP0001666_abnormal_nutrient_absorption1.96214125
34MP0003690_abnormal_glial_cell1.95117716
35MP0002736_abnormal_nociception_after1.87595217
36MP0003191_abnormal_cellular_cholesterol1.86693162
37MP0004885_abnormal_endolymph1.85994052
38MP0002067_abnormal_sensory_capabilities1.83027688
39MP0001915_intracranial_hemorrhage1.80598909
40MP0002733_abnormal_thermal_nociception1.79794128
41MP0001958_emphysema1.78576599
42MP0001970_abnormal_pain_threshold1.74845147
43MP0004924_abnormal_behavior1.70723651
44MP0005386_behavior/neurological_phenoty1.70723651
45MP0002089_abnormal_postnatal_growth/wei1.70363353
46MP0001529_abnormal_vocalization1.68526109
47MP0003941_abnormal_skin_development1.67496894
48MP0003091_abnormal_cell_migration1.64363135
49MP0001905_abnormal_dopamine_level1.59228667
50MP0002896_abnormal_bone_mineralization1.56991624
51MP0005023_abnormal_wound_healing1.55501995
52MP0000566_synostosis1.54252330
53* MP0008569_lethality_at_weaning1.52895641
54MP0001849_ear_inflammation1.52321300
55MP0006276_abnormal_autonomic_nervous1.52173703
56MP0002877_abnormal_melanocyte_morpholog1.51637615
57MP0002184_abnormal_innervation1.50863937
58MP0002557_abnormal_social/conspecific_i1.49411309
59MP0010329_abnormal_lipoprotein_level1.49249576
60MP0005451_abnormal_body_composition1.47187003
61MP0003633_abnormal_nervous_system1.46184361
62MP0004142_abnormal_muscle_tone1.45832921
63* MP0000955_abnormal_spinal_cord1.45186933
64MP0005076_abnormal_cell_differentiation1.42890137
65MP0000604_amyloidosis1.42757214
66MP0000579_abnormal_nail_morphology1.42732241
67MP0004811_abnormal_neuron_physiology1.41701321
68MP0004742_abnormal_vestibular_system1.41658982
69* MP0002882_abnormal_neuron_morphology1.40274822
70* MP0002066_abnormal_motor_capabilities/c1.39393044
71MP0010234_abnormal_vibrissa_follicle1.36646468
72MP0003631_nervous_system_phenotype1.35961132
73MP0005646_abnormal_pituitary_gland1.34897996
74MP0003300_gastrointestinal_ulcer1.31665491
75MP0003632_abnormal_nervous_system1.27485623
76MP0006054_spinal_hemorrhage1.27212213
77MP0005551_abnormal_eye_electrophysiolog1.25389831
78MP0003279_aneurysm1.25303693
79MP0003453_abnormal_keratinocyte_physiol1.24929772
80MP0009384_cardiac_valve_regurgitation1.24629339
81MP0002060_abnormal_skin_morphology1.24511399
82* MP0003634_abnormal_glial_cell1.24108202
83MP0004858_abnormal_nervous_system1.22487509
84MP0004264_abnormal_extraembryonic_tissu1.20959016
85MP0010352_gastrointestinal_tract_polyps1.20821386
86* MP0002229_neurodegeneration1.18441434
87MP0005171_absent_coat_pigmentation1.17595392
88MP0001984_abnormal_olfaction1.15698809
89MP0003183_abnormal_peptide_metabolism1.11898566
90MP0000767_abnormal_smooth_muscle1.11499718
91MP0005645_abnormal_hypothalamus_physiol1.10955948
92MP0000762_abnormal_tongue_morphology1.09295533
93MP0000534_abnormal_ureter_morphology1.09173824
94MP0001177_atelectasis1.08270375
95MP0002909_abnormal_adrenal_gland1.07751740
96MP0001502_abnormal_circadian_rhythm1.06286801
97MP0004233_abnormal_muscle_weight1.05731910
98MP0003252_abnormal_bile_duct1.04542533
99MP0003879_abnormal_hair_cell1.02261740
100* MP0002152_abnormal_brain_morphology1.00723051
101MP0008874_decreased_physiological_sensi0.99024851
102* MP0005409_darkened_coat_color0.97558988
103MP0002139_abnormal_hepatobiliary_system0.97354166
104MP0003950_abnormal_plasma_membrane0.96763635
105MP0008260_abnormal_autophagy0.94247961
106MP0005503_abnormal_tendon_morphology0.94050657
107MP0005360_urolithiasis0.94027527
108MP0009053_abnormal_anal_canal0.93553630
109MP0005535_abnormal_body_temperature0.91421950
110MP0000003_abnormal_adipose_tissue0.90049975
111MP0001485_abnormal_pinna_reflex0.88226776
112MP0002837_dystrophic_cardiac_calcinosis0.87903915
113MP0002069_abnormal_eating/drinking_beha0.87824593
114MP0000467_abnormal_esophagus_morphology0.87684077
115MP0001299_abnormal_eye_distance/0.87362769
116MP0002090_abnormal_vision0.86740205
117MP0001963_abnormal_hearing_physiology0.86602252
118MP0003115_abnormal_respiratory_system0.85654915
119MP0003385_abnormal_body_wall0.84817476
120MP0003123_paternal_imprinting0.83427760
121MP0001188_hyperpigmentation0.82203417
122MP0006138_congestive_heart_failure0.79878088
123MP0005085_abnormal_gallbladder_physiolo0.79669698
124MP0004145_abnormal_muscle_electrophysio0.78976299
125MP0002752_abnormal_somatic_nervous0.78774067
126MP0005408_hypopigmentation0.77348554
127MP0000537_abnormal_urethra_morphology0.77234663
128MP0002876_abnormal_thyroid_physiology0.77093359
129MP0000751_myopathy0.76926818
130MP0000569_abnormal_digit_pigmentation0.76523121
131MP0001661_extended_life_span0.75753790
132MP0008872_abnormal_physiological_respon0.74552209
133MP0002971_abnormal_brown_adipose0.73743130
134MP0004085_abnormal_heartbeat0.72772572
135MP0003075_altered_response_to0.71785024
136MP0003787_abnormal_imprinting0.71500902
137MP0008875_abnormal_xenobiotic_pharmacok0.71242033
138MP0005197_abnormal_uvea_morphology0.70291345
139MP0000609_abnormal_liver_physiology0.70069544
140MP0010386_abnormal_urinary_bladder0.69544079
141MP0004019_abnormal_vitamin_homeostasis0.69086103
142MP0010630_abnormal_cardiac_muscle0.68465302
143MP0005666_abnormal_adipose_tissue0.68067392
144MP0005375_adipose_tissue_phenotype0.68004860
145MP0005164_abnormal_response_to0.67964496
146MP0003942_abnormal_urinary_system0.67782898
147MP0002998_abnormal_bone_remodeling0.67192561
148MP0001348_abnormal_lacrimal_gland0.66688492
149MP0000733_abnormal_muscle_development0.66348060
150MP0000013_abnormal_adipose_tissue0.65593329
151MP0003195_calcinosis0.65485247
152MP0005248_abnormal_Harderian_gland0.64348393
153MP0004185_abnormal_adipocyte_glucose0.64289743
154MP0005508_abnormal_skeleton_morphology0.63526778
155MP0003122_maternal_imprinting0.62482221
156MP0000631_abnormal_neuroendocrine_gland0.62427803
157MP0002108_abnormal_muscle_morphology0.62091371
158MP0005623_abnormal_meninges_morphology0.61399161
159MP0001664_abnormal_digestion0.60790379
160MP0003137_abnormal_impulse_conducting0.59374946
161MP0004043_abnormal_pH_regulation0.57468012
162MP0003172_abnormal_lysosome_physiology0.57379858
163MP0000462_abnormal_digestive_system0.56806708
164MP0003868_abnormal_feces_composition0.53762232
165MP0005187_abnormal_penis_morphology0.53614061
166MP0001943_abnormal_respiration0.52950091
167MP0000747_muscle_weakness0.51928936
168MP0004130_abnormal_muscle_cell0.51642788
169MP0002295_abnormal_pulmonary_circulatio0.51213095
170MP0002118_abnormal_lipid_homeostasis0.51027020
171MP0005195_abnormal_posterior_eye0.50246129

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.32874455
2Myokymia (HP:0002411)5.80661034
3Focal seizures (HP:0007359)4.87016740
4Neurofibrillary tangles (HP:0002185)4.55596120
5Protrusio acetabuli (HP:0003179)4.39479168
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.21889780
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.21889780
8Abnormality of the corticospinal tract (HP:0002492)4.18616263
9Cerebral inclusion bodies (HP:0100314)4.15020595
10Atonic seizures (HP:0010819)4.02252178
11Complement deficiency (HP:0004431)3.99812984
12Action tremor (HP:0002345)3.93021839
13Supranuclear gaze palsy (HP:0000605)3.88449327
14Visual hallucinations (HP:0002367)3.82551830
15Epileptic encephalopathy (HP:0200134)3.77664947
16Insidious onset (HP:0003587)3.73361666
17Termporal pattern (HP:0011008)3.73361666
18Progressive cerebellar ataxia (HP:0002073)3.73069474
19Premature rupture of membranes (HP:0001788)3.72728863
20Dysmetria (HP:0001310)3.53382878
21Hyperventilation (HP:0002883)3.50575510
22Absence seizures (HP:0002121)3.48520503
23Spastic gait (HP:0002064)3.46849395
24Scanning speech (HP:0002168)3.45433848
25Abnormality of complement system (HP:0005339)3.35459607
26Arterial tortuosity (HP:0005116)3.31698785
27Generalized tonic-clonic seizures (HP:0002069)3.28677514
28Febrile seizures (HP:0002373)3.26752663
29Broad-based gait (HP:0002136)3.26380585
30Impaired vibration sensation in the lower limbs (HP:0002166)3.25165462
31Dialeptic seizures (HP:0011146)3.24795205
32Intention tremor (HP:0002080)3.22448998
33Atrophic scars (HP:0001075)3.21648091
34Vascular tortuosity (HP:0004948)3.18812084
35Urinary bladder sphincter dysfunction (HP:0002839)3.13640984
36Ankle clonus (HP:0011448)3.08187924
37Dysdiadochokinesis (HP:0002075)3.07016105
38Prolonged partial thromboplastin time (HP:0003645)3.05449514
39Abnormality of the common coagulation pathway (HP:0010990)3.04199221
40Glomerulonephritis (HP:0000099)2.95741006
41Mitral stenosis (HP:0001718)2.90728118
42Gaze-evoked nystagmus (HP:0000640)2.87664664
43Poor eye contact (HP:0000817)2.85055391
44Systemic lupus erythematosus (HP:0002725)2.84977049
45Cerebral aneurysm (HP:0004944)2.81832543
46Truncal ataxia (HP:0002078)2.79658667
47Urinary urgency (HP:0000012)2.77464253
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77357006
49Flat acetabular roof (HP:0003180)2.76296411
50Joint hemorrhage (HP:0005261)2.70290529
51Abnormal eating behavior (HP:0100738)2.70220900
52Drooling (HP:0002307)2.69046747
53Excessive salivation (HP:0003781)2.69046747
54Anxiety (HP:0000739)2.68784617
55Abnormal social behavior (HP:0012433)2.67733736
56Impaired social interactions (HP:0000735)2.67733736
57Lower limb muscle weakness (HP:0007340)2.64989592
58Hypobetalipoproteinemia (HP:0003563)2.61884260
59Blue irides (HP:0000635)2.61303729
60Aortic dissection (HP:0002647)2.57783627
61Postural instability (HP:0002172)2.55860712
62Vertebral compression fractures (HP:0002953)2.51994184
63Abnormality of carpal bone ossification (HP:0006257)2.49001239
64Neonatal short-limb short stature (HP:0008921)2.47882379
65Torticollis (HP:0000473)2.47523521
66Sensory axonal neuropathy (HP:0003390)2.45846881
67Depression (HP:0000716)2.42492468
68Xanthomatosis (HP:0000991)2.41406594
69Mutism (HP:0002300)2.40033405
70Hypercholesterolemia (HP:0003124)2.35208598
71Pheochromocytoma (HP:0002666)2.35153857
72Epileptiform EEG discharges (HP:0011182)2.34631499
73Wormian bones (HP:0002645)2.29631763
74Akinesia (HP:0002304)2.29287240
75Generalized myoclonic seizures (HP:0002123)2.27765897
76Impaired vibratory sensation (HP:0002495)2.27694240
77Onion bulb formation (HP:0003383)2.26656778
78EEG with generalized epileptiform discharges (HP:0011198)2.26387952
79Cardiovascular calcification (HP:0011915)2.25368092
80Hemorrhage of the eye (HP:0011885)2.22300564
81Shallow orbits (HP:0000586)2.22006433
82Focal dystonia (HP:0004373)2.19246427
83Polyphagia (HP:0002591)2.19099661
84Abnormal ossification of hand bones (HP:0005921)2.18099809
85Papilledema (HP:0001085)2.17919908
86Urinary glycosaminoglycan excretion (HP:0003541)2.17343453
87Mucopolysacchariduria (HP:0008155)2.17343453
88Hypsarrhythmia (HP:0002521)2.16618999
89Genetic anticipation (HP:0003743)2.16064166
90Amblyopia (HP:0000646)2.15850626
91Cervical subluxation (HP:0003308)2.15618961
92Fragile skin (HP:0001030)2.15576032
93Asymmetry of the thorax (HP:0001555)2.15036991
94Neuronal loss in central nervous system (HP:0002529)2.14613067
95Hemiparesis (HP:0001269)2.13543189
96Absent speech (HP:0001344)2.12169854
97Megalencephaly (HP:0001355)2.11312980
98Peripheral hypomyelination (HP:0007182)2.10982327
99Vascular calcification (HP:0004934)2.10976806
100Progressive inability to walk (HP:0002505)2.09416727
101Diplopia (HP:0000651)2.08380546
102Abnormality of binocular vision (HP:0011514)2.08380546
103Limb dystonia (HP:0002451)2.06152935
104Bladder diverticulum (HP:0000015)2.05706411
105Abnormality of the Achilles tendon (HP:0005109)2.05371826
106Skin nodule (HP:0200036)2.04661570
107Mitral valve prolapse (HP:0001634)2.04325230
108Craniofacial dystonia (HP:0012179)2.04189930
109Abnormality of the acetabulum (HP:0003170)2.03703820
110Morphological abnormality of the pyramidal tract (HP:0002062)2.01191790
111Aplasia involving bones of the upper limbs (HP:0009823)2.00758296
112Aplasia of the phalanges of the hand (HP:0009802)2.00758296
113Aplasia involving bones of the extremities (HP:0009825)2.00758296
114Peritonitis (HP:0002586)2.00667029
115Ulnar bowing (HP:0003031)1.99690835
116Clonus (HP:0002169)1.99400967
117Dysostosis multiplex (HP:0000943)1.99031880
118Aneurysm (HP:0002617)1.98921226
119Conjugated hyperbilirubinemia (HP:0002908)1.98638786
120Back pain (HP:0003418)1.97003492
121Menorrhagia (HP:0000132)1.96474519
122Abnormality of polysaccharide metabolism (HP:0011012)1.95370126
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95370126
124Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95370126
125Nephritis (HP:0000123)1.95163145
126Aortic aneurysm (HP:0004942)1.94126971
127Fetal akinesia sequence (HP:0001989)1.92535903
128Hemiplegia (HP:0002301)1.91256024
129Abnormality of salivation (HP:0100755)1.89686945
130Blue sclerae (HP:0000592)1.89321215
131Status epilepticus (HP:0002133)1.89252757
132Hypolipoproteinemia (HP:0010981)1.86354374
133Increased circulating renin level (HP:0000848)1.86302094
134Clumsiness (HP:0002312)1.86177197
135Neuroendocrine neoplasm (HP:0100634)1.85872157
136Stereotypic behavior (HP:0000733)1.85674697
137Thin bony cortex (HP:0002753)1.85451875
138Cupped ribs (HP:0000887)1.85377002
139Abnormal hand bone ossification (HP:0010660)1.85076449
140Bradykinesia (HP:0002067)1.84867366
141Hammertoe (HP:0001765)1.84860346
142Vertebral arch anomaly (HP:0008438)1.84852269
143Hyperextensible skin (HP:0000974)1.84510554
144Psychosis (HP:0000709)1.83424952
145Cerebral hemorrhage (HP:0001342)1.83106937
146Abnormality of dentin (HP:0010299)1.82192060
147Impaired smooth pursuit (HP:0007772)1.80577160
148Hyperacusis (HP:0010780)1.80397443
149Advanced eruption of teeth (HP:0006288)1.80395839
150Retinal dysplasia (HP:0007973)1.79369195
151Abnormal delivery (HP:0001787)1.79069676
152Thickened helices (HP:0000391)1.78931579
153Abnormality of saccadic eye movements (HP:0000570)1.76687439
154Widely spaced teeth (HP:0000687)1.76432323
155Neonatal death (HP:0003811)1.76046052
156Right ventricular cardiomyopathy (HP:0011663)1.75213958
157Deep venous thrombosis (HP:0002625)1.75082990
158Amyloidosis (HP:0011034)1.74754088
159Coxa vara (HP:0002812)1.74686812
160Mitral regurgitation (HP:0001653)1.74025358
161Bronchomalacia (HP:0002780)1.73515649
162Achilles tendon contracture (HP:0001771)1.72978328
163Gait ataxia (HP:0002066)1.72685086
164Postural tremor (HP:0002174)1.72055098
165Abnormality of the intrinsic pathway (HP:0010989)1.71299995
166Bowel incontinence (HP:0002607)1.70423622
167Soft skin (HP:0000977)1.70279063
168Fair hair (HP:0002286)1.70063123
169Slow saccadic eye movements (HP:0000514)1.69896986
170Spinal rigidity (HP:0003306)1.69734477
171Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69706496
172Biconcave vertebral bodies (HP:0004586)1.68986989
173Spastic tetraparesis (HP:0001285)1.68816421
174Hypoplastic nipples (HP:0002557)1.68231831
175Ankle contracture (HP:0006466)1.66977200
176Myocardial infarction (HP:0001658)1.66037638
177Abnormality of the lumbar spine (HP:0100712)1.65618361
178Upper limb amyotrophy (HP:0009129)1.65595241
179Distal upper limb amyotrophy (HP:0007149)1.65595241
180Osteoarthritis (HP:0002758)1.64253322
181Short nail (HP:0001799)1.64107472
182Ankyloglossia (HP:0010296)1.62967956
183Broad metatarsal (HP:0001783)1.61077011
184Wide anterior fontanel (HP:0000260)1.60712398
185Intrahepatic cholestasis (HP:0001406)1.60573895
186Dilatation of the ascending aorta (HP:0005111)1.60415345
187Turricephaly (HP:0000262)1.59398439
188Broad face (HP:0000283)1.58388956
189Flared iliac wings (HP:0002869)1.58128391
190Abnormal tarsal ossification (HP:0008369)1.58100778
191Ovoid vertebral bodies (HP:0003300)1.56961299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.36926819
2RIPK13.77981200
3NTRK33.60465952
4PDGFRA3.27026160
5TRIB33.11331123
6FGFR42.96739907
7MARK12.86284155
8MAP3K92.84989472
9CDK122.71473792
10MAP3K42.51412818
11STK392.28065275
12MINK12.17578514
13ERN12.17241903
14TNIK2.16233147
15NTRK12.08940431
16OXSR12.08428270
17PAK62.06795695
18CASK2.05748828
19DDR22.01230786
20DAPK21.98559292
21EEF2K1.89935506
22MAP2K71.89538543
23RIPK41.88683509
24FGFR31.79770995
25SIK11.76445654
26NTRK21.68747341
27PNCK1.68728494
28MAP2K41.67925452
29LATS11.64986298
30KSR21.63035488
31PTK21.58839024
32TTN1.48299289
33CDK51.45314066
34PLK21.44678730
35TGFBR21.39537683
36MST1R1.36262056
37PRKD31.36006173
38PKN21.34858392
39PRPF4B1.34115902
40FGFR21.32744590
41EPHB21.28866737
42EPHA21.24284208
43FES1.22387858
44GRK51.22134005
45KSR11.21497654
46TYRO31.19799089
47CAMK2B1.19528622
48CAMK1G1.18902808
49IRAK31.18635307
50CAMKK11.18148049
51CAMK2A1.17377000
52MAPK131.17101092
53SGK2231.16521148
54SGK4941.16521148
55PDGFRB1.16066508
56UHMK11.16058016
57CDK191.15737405
58AKT31.14557476
59PAK31.12791280
60PKN11.11471672
61BCR1.10570746
62SCYL21.08935967
63WNK11.07344979
64MAP3K21.06370532
65CSNK1G21.06197974
66MTOR1.05812421
67NEK91.05542429
68MAP3K121.03909973
69PHKG21.00962669
70PHKG11.00962669
71PTK2B0.98747150
72FGR0.96265049
73MAP3K130.96019819
74CDC42BPA0.95380144
75ARAF0.94426164
76PRKCG0.94114816
77PRKCH0.93991910
78EPHB10.93861103
79SMG10.93169322
80PAK20.91962318
81TESK10.88774154
82STK110.87721318
83NEK60.85154530
84CAMK2D0.84667535
85WNK40.84386725
86STK380.82978372
87MOS0.82174408
88RET0.81526139
89ROCK20.78627776
90CAMK2G0.78257545
91RPS6KA20.77350742
92BMPR20.77194661
93MARK20.76830262
94PAK40.76090070
95CDK140.75869261
96CDK150.75341708
97CSNK1A1L0.74924311
98CDK180.74508530
99SIK20.74271178
100PDPK10.73668009
101EPHA30.72317013
102CSNK1G30.71921962
103SGK10.71846472
104PRKCE0.71154579
105ICK0.71039606
106MAPKAPK50.70260549
107DAPK10.69702860
108FGFR10.67716191
109FYN0.66571943
110MAP3K10.64420628
111CAMK10.62814959
112CAMKK20.61933378
113CDK11A0.61548348
114INSRR0.61277897
115DYRK1A0.60967980
116PTK60.59184109
117SGK20.58336110
118PRKCQ0.57767796
119CDK60.57551943
120PDK10.57131324
121BRD40.56402594
122ERBB20.56052784
123MAP3K60.55790992
124MAP3K30.55500275
125PRKCZ0.55372753
126RAF10.54876024
127JAK10.54812903
128LMTK20.53267676
129CSNK1G10.53148734
130SGK30.51030934
131FER0.50497527
132MAPK110.50318974
133PIK3CA0.50034059
134ERBB40.48273451
135LATS20.47381785
136PRKAA20.47183002
137RPS6KA30.47096450
138DMPK0.44881145
139LIMK10.44668369
140CAMK1D0.43465283
141BMX0.43448931
142PRKG10.43442954
143RPS6KB10.43442740
144SRC0.42835527
145MAP3K70.42567457
146PRKD20.41045282
147PINK10.40681467
148MET0.38266598
149MAPK100.38203377
150PIM20.37783209
151TRPM70.36818774
152PRKG20.35012566
153MAPKAPK30.34441108

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.09528171
2Glutamatergic synapse_Homo sapiens_hsa047242.39251007
3GABAergic synapse_Homo sapiens_hsa047272.39065748
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35934763
5Synaptic vesicle cycle_Homo sapiens_hsa047212.30092378
6Nitrogen metabolism_Homo sapiens_hsa009102.26726598
7Circadian entrainment_Homo sapiens_hsa047132.23919842
8Morphine addiction_Homo sapiens_hsa050322.17629836
9Long-term potentiation_Homo sapiens_hsa047202.12302180
10Olfactory transduction_Homo sapiens_hsa047401.94265128
11Salivary secretion_Homo sapiens_hsa049701.93363085
12Amphetamine addiction_Homo sapiens_hsa050311.92841691
13Other glycan degradation_Homo sapiens_hsa005111.92033249
14ECM-receptor interaction_Homo sapiens_hsa045121.84337458
15Dopaminergic synapse_Homo sapiens_hsa047281.78860699
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.69336640
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65069071
18Serotonergic synapse_Homo sapiens_hsa047261.63347586
19Gastric acid secretion_Homo sapiens_hsa049711.62766972
20Long-term depression_Homo sapiens_hsa047301.60275414
21Cholinergic synapse_Homo sapiens_hsa047251.59725790
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58290849
23Renin secretion_Homo sapiens_hsa049241.53226195
24Insulin secretion_Homo sapiens_hsa049111.51261040
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50426401
26Cocaine addiction_Homo sapiens_hsa050301.49639457
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46028569
28Axon guidance_Homo sapiens_hsa043601.42961283
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41362214
30Taste transduction_Homo sapiens_hsa047421.41206942
31Phenylalanine metabolism_Homo sapiens_hsa003601.33892440
32Oxytocin signaling pathway_Homo sapiens_hsa049211.32302941
33Focal adhesion_Homo sapiens_hsa045101.31055617
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31039471
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26377040
36Calcium signaling pathway_Homo sapiens_hsa040201.25805172
37Amoebiasis_Homo sapiens_hsa051461.25242489
38Butanoate metabolism_Homo sapiens_hsa006501.22819036
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20639106
40GnRH signaling pathway_Homo sapiens_hsa049121.17920491
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17475956
42Protein digestion and absorption_Homo sapiens_hsa049741.14455348
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13589483
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13454678
45Adherens junction_Homo sapiens_hsa045201.13016534
46Gap junction_Homo sapiens_hsa045401.12316961
47Collecting duct acid secretion_Homo sapiens_hsa049661.12088700
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09623277
49Starch and sucrose metabolism_Homo sapiens_hsa005001.08522219
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07264481
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06910031
52cAMP signaling pathway_Homo sapiens_hsa040241.06701302
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06610248
54Steroid biosynthesis_Homo sapiens_hsa001001.06568602
55Fatty acid degradation_Homo sapiens_hsa000711.04928602
56Phototransduction_Homo sapiens_hsa047441.01962249
57Bile secretion_Homo sapiens_hsa049761.00865793
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.99124550
59Proteoglycans in cancer_Homo sapiens_hsa052050.98822885
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.97735843
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96573823
62Vitamin B6 metabolism_Homo sapiens_hsa007500.96290496
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.96052742
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95604215
65Fatty acid elongation_Homo sapiens_hsa000620.93848286
66Renin-angiotensin system_Homo sapiens_hsa046140.93728640
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92939329
68Fat digestion and absorption_Homo sapiens_hsa049750.91804529
69Type II diabetes mellitus_Homo sapiens_hsa049300.91099457
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90945432
71Tyrosine metabolism_Homo sapiens_hsa003500.90588089
72Lysosome_Homo sapiens_hsa041420.89483477
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88059494
74Dorso-ventral axis formation_Homo sapiens_hsa043200.87448938
75Retinol metabolism_Homo sapiens_hsa008300.85584879
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85228762
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84070080
78ErbB signaling pathway_Homo sapiens_hsa040120.84064356
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83966879
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.83828379
81Estrogen signaling pathway_Homo sapiens_hsa049150.83732164
82Melanogenesis_Homo sapiens_hsa049160.82834730
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82616504
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.82203519
85Chronic myeloid leukemia_Homo sapiens_hsa052200.82174475
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81891071
87Arginine biosynthesis_Homo sapiens_hsa002200.81004182
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80777142
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80658269
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.80137452
91Endometrial cancer_Homo sapiens_hsa052130.80084747
92Galactose metabolism_Homo sapiens_hsa000520.79692890
93Vitamin digestion and absorption_Homo sapiens_hsa049770.78790858
94Glioma_Homo sapiens_hsa052140.78537858
95Pancreatic secretion_Homo sapiens_hsa049720.77508253
96Ether lipid metabolism_Homo sapiens_hsa005650.77473993
97Small cell lung cancer_Homo sapiens_hsa052220.74825897
98Insulin signaling pathway_Homo sapiens_hsa049100.74462828
99Bladder cancer_Homo sapiens_hsa052190.73957602
100Thyroid hormone synthesis_Homo sapiens_hsa049180.72388926
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71793874
102Choline metabolism in cancer_Homo sapiens_hsa052310.71462120
103Fructose and mannose metabolism_Homo sapiens_hsa000510.71291651
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69802675
105Insulin resistance_Homo sapiens_hsa049310.69338146
106Cardiac muscle contraction_Homo sapiens_hsa042600.68950955
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68341889
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.67979637
109Arginine and proline metabolism_Homo sapiens_hsa003300.66543806
110Vibrio cholerae infection_Homo sapiens_hsa051100.66474426
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.65985347
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65750097
113AMPK signaling pathway_Homo sapiens_hsa041520.65182304
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65162745
115Thyroid cancer_Homo sapiens_hsa052160.64401972
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64329428
117Sphingolipid metabolism_Homo sapiens_hsa006000.64212525
118Non-small cell lung cancer_Homo sapiens_hsa052230.63773468
119Ovarian steroidogenesis_Homo sapiens_hsa049130.63030200
120Pancreatic cancer_Homo sapiens_hsa052120.62092627
121Biosynthesis of amino acids_Homo sapiens_hsa012300.61756183
122Chemical carcinogenesis_Homo sapiens_hsa052040.61698914
123Pertussis_Homo sapiens_hsa051330.60923936
124mTOR signaling pathway_Homo sapiens_hsa041500.60748260
125Lysine degradation_Homo sapiens_hsa003100.59111620
126Ras signaling pathway_Homo sapiens_hsa040140.58308131
127Staphylococcus aureus infection_Homo sapiens_hsa051500.57875055
128Fatty acid biosynthesis_Homo sapiens_hsa000610.57873867
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.56885631
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.56418789
131Dilated cardiomyopathy_Homo sapiens_hsa054140.56177067
132Notch signaling pathway_Homo sapiens_hsa043300.52544635
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52257444
134N-Glycan biosynthesis_Homo sapiens_hsa005100.51437809
135Renal cell carcinoma_Homo sapiens_hsa052110.50919574
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49900754
137MicroRNAs in cancer_Homo sapiens_hsa052060.48923978
138MAPK signaling pathway_Homo sapiens_hsa040100.48614724
139Alzheimers disease_Homo sapiens_hsa050100.47645394
140Prion diseases_Homo sapiens_hsa050200.47268034
141Fatty acid metabolism_Homo sapiens_hsa012120.47202848
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46365299
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44480836
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.43588212
145Rap1 signaling pathway_Homo sapiens_hsa040150.42522732
146African trypanosomiasis_Homo sapiens_hsa051430.40987669
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39000701
148Sulfur metabolism_Homo sapiens_hsa009200.38765941
149VEGF signaling pathway_Homo sapiens_hsa043700.37962321
150Inositol phosphate metabolism_Homo sapiens_hsa005620.35763449
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34602683
152Glucagon signaling pathway_Homo sapiens_hsa049220.34574754
153Endocytosis_Homo sapiens_hsa041440.33787257
154Histidine metabolism_Homo sapiens_hsa003400.33390148
155PPAR signaling pathway_Homo sapiens_hsa033200.32698410
156Glycerolipid metabolism_Homo sapiens_hsa005610.30483230
157ABC transporters_Homo sapiens_hsa020100.29770111
158Complement and coagulation cascades_Homo sapiens_hsa046100.29653606
159Wnt signaling pathway_Homo sapiens_hsa043100.27948571
160Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24996539
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24032866

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