

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | presynaptic membrane assembly (GO:0097105) | 4.95252946 |
| 2 | synaptic vesicle maturation (GO:0016188) | 4.57805292 |
| 3 | presynaptic membrane organization (GO:0097090) | 4.56941304 |
| 4 | cerebellar granule cell differentiation (GO:0021707) | 4.44956599 |
| 5 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.42298249 |
| 6 | L-amino acid import (GO:0043092) | 4.42042604 |
| 7 | locomotory exploration behavior (GO:0035641) | 4.34590540 |
| 8 | startle response (GO:0001964) | 4.31631422 |
| 9 | postsynaptic membrane organization (GO:0001941) | 4.28319685 |
| 10 | layer formation in cerebral cortex (GO:0021819) | 4.26496527 |
| 11 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.17751935 |
| 12 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.03023217 |
| 13 | glutamate secretion (GO:0014047) | 3.87511549 |
| 14 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.79804845 |
| 15 | proline transport (GO:0015824) | 3.74906060 |
| 16 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.70788834 |
| 17 | serotonin metabolic process (GO:0042428) | 3.65154678 |
| 18 | vocalization behavior (GO:0071625) | 3.64645860 |
| 19 | amino acid import (GO:0043090) | 3.64572424 |
| 20 | neuronal ion channel clustering (GO:0045161) | 3.60454498 |
| 21 | synaptic vesicle exocytosis (GO:0016079) | 3.54530753 |
| 22 | auditory behavior (GO:0031223) | 3.50702497 |
| 23 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.45868244 |
| 24 | C4-dicarboxylate transport (GO:0015740) | 3.45446271 |
| 25 | negative regulation of dendrite development (GO:2000171) | 3.40459939 |
| 26 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.38812178 |
| 27 | exploration behavior (GO:0035640) | 3.36690778 |
| 28 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.36662101 |
| 29 | sodium ion export (GO:0071436) | 3.35093151 |
| 30 | membrane depolarization (GO:0051899) | 3.33396882 |
| 31 | activation of protein kinase A activity (GO:0034199) | 3.28873501 |
| 32 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.26019123 |
| 33 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.25398430 |
| 34 | dendrite morphogenesis (GO:0048813) | 3.24008410 |
| 35 | primary amino compound metabolic process (GO:1901160) | 3.23339016 |
| 36 | transmission of nerve impulse (GO:0019226) | 3.22744979 |
| 37 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.22067802 |
| 38 | regulation of synapse maturation (GO:0090128) | 3.19740456 |
| 39 | regulation of neurotransmitter transport (GO:0051588) | 3.18258954 |
| 40 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.17663506 |
| 41 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.14816749 |
| 42 | cellular potassium ion homeostasis (GO:0030007) | 3.14089337 |
| 43 | neurotransmitter secretion (GO:0007269) | 3.13996860 |
| 44 | cell differentiation in hindbrain (GO:0021533) | 3.12508614 |
| 45 | protein localization to synapse (GO:0035418) | 3.11429706 |
| 46 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 3.11256109 |
| 47 | detection of calcium ion (GO:0005513) | 3.09713144 |
| 48 | cochlea development (GO:0090102) | 3.09296072 |
| 49 | potassium ion homeostasis (GO:0055075) | 3.09125163 |
| 50 | regulation of synapse structural plasticity (GO:0051823) | 3.07824305 |
| 51 | adult walking behavior (GO:0007628) | 3.06804761 |
| 52 | response to auditory stimulus (GO:0010996) | 3.05676367 |
| 53 | neuromuscular process (GO:0050905) | 3.05363656 |
| 54 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.05185938 |
| 55 | dendritic spine morphogenesis (GO:0060997) | 3.04101983 |
| 56 | establishment of nucleus localization (GO:0040023) | 3.00309587 |
| 57 | central nervous system myelination (GO:0022010) | 3.00097114 |
| 58 | axon ensheathment in central nervous system (GO:0032291) | 3.00097114 |
| 59 | cell communication by electrical coupling (GO:0010644) | 2.99539140 |
| 60 | regulation of synaptic vesicle transport (GO:1902803) | 2.99183854 |
| 61 | behavioral fear response (GO:0001662) | 2.98045949 |
| 62 | behavioral defense response (GO:0002209) | 2.98045949 |
| 63 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.97983863 |
| 64 | synaptic transmission (GO:0007268) | 2.94801220 |
| 65 | cell migration in hindbrain (GO:0021535) | 2.93743680 |
| 66 | regulation of dendritic spine development (GO:0060998) | 2.93079379 |
| 67 | acidic amino acid transport (GO:0015800) | 2.92436005 |
| 68 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.91635484 |
| 69 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.90820108 |
| 70 | positive regulation of dendritic spine development (GO:0060999) | 2.89284936 |
| 71 | innervation (GO:0060384) | 2.87342643 |
| 72 | alanine transport (GO:0032328) | 2.82232038 |
| 73 | cell communication involved in cardiac conduction (GO:0086065) | 2.81233904 |
| 74 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.77484897 |
| 75 | axonal fasciculation (GO:0007413) | 2.76180201 |
| 76 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.75859300 |
| 77 | neuromuscular process controlling balance (GO:0050885) | 2.69442284 |
| 78 | neuron recognition (GO:0008038) | 2.68449114 |
| 79 | gamma-aminobutyric acid transport (GO:0015812) | 2.66104748 |
| 80 | cellular sodium ion homeostasis (GO:0006883) | 2.65386870 |
| 81 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.65143749 |
| 82 | regulation of ARF protein signal transduction (GO:0032012) | 2.64855198 |
| 83 | negative regulation of sodium ion transport (GO:0010766) | 2.61934530 |
| 84 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.60077895 |
| 85 | regulation of clathrin-mediated endocytosis (GO:2000369) | 2.59029641 |
| 86 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.56956900 |
| 87 | neuron cell-cell adhesion (GO:0007158) | 2.56059573 |
| 88 | vesicle transport along microtubule (GO:0047496) | 2.55030619 |
| 89 | nerve growth factor signaling pathway (GO:0038180) | 2.54005980 |
| 90 | axon extension (GO:0048675) | 2.53593953 |
| 91 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.49948922 |
| 92 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.49461696 |
| 93 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.48964434 |
| 94 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.47822526 |
| 95 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.47211756 |
| 96 | plasma membrane repair (GO:0001778) | 2.47028438 |
| 97 | clathrin coat assembly (GO:0048268) | 2.39684038 |
| 98 | positive regulation of fibroblast migration (GO:0010763) | 2.39179526 |
| 99 | nucleobase catabolic process (GO:0046113) | 2.38427263 |
| 100 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.38305556 |
| 101 | glutamate receptor signaling pathway (GO:0007215) | 2.38034828 |
| 102 | suckling behavior (GO:0001967) | 2.37860658 |
| 103 | synaptic transmission, glutamatergic (GO:0035249) | 2.36019325 |
| 104 | membrane depolarization during action potential (GO:0086010) | 2.35669626 |
| 105 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.35433946 |
| 106 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.33969205 |
| 107 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.33839656 |
| 108 | neurotransmitter transport (GO:0006836) | 2.33489164 |
| 109 | axon extension involved in axon guidance (GO:0048846) | 2.32580259 |
| 110 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.32580259 |
| 111 | positive regulation of synapse maturation (GO:0090129) | 2.32058729 |
| 112 | positive regulation of muscle hypertrophy (GO:0014742) | 2.31557027 |
| 113 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 2.31557027 |
| 114 | neuronal action potential propagation (GO:0019227) | 2.30798298 |
| 115 | organelle transport along microtubule (GO:0072384) | 2.28894431 |
| 116 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.28719380 |
| 117 | positive regulation of axon extension (GO:0045773) | 2.28204609 |
| 118 | regulation of vesicle fusion (GO:0031338) | 2.28050634 |
| 119 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.26550608 |
| 120 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.25708324 |
| 121 | neuron projection extension (GO:1990138) | 2.25634122 |
| 122 | regulation of postsynaptic membrane potential (GO:0060078) | 2.25304452 |
| 123 | prepulse inhibition (GO:0060134) | 2.25112676 |
| 124 | regulation of synaptic plasticity (GO:0048167) | 2.24167263 |
| 125 | mating behavior (GO:0007617) | 2.24059163 |
| 126 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.22209991 |
| 127 | glycine transport (GO:0015816) | 2.19856855 |
| 128 | regulation of neurotransmitter secretion (GO:0046928) | 2.19560518 |
| 129 | neuron-neuron synaptic transmission (GO:0007270) | 2.18773080 |
| 130 | axon cargo transport (GO:0008088) | 2.18454031 |
| 131 | regulation of cAMP-dependent protein kinase activity (GO:2000479) | 2.17854699 |
| 132 | positive regulation of membrane potential (GO:0045838) | 2.17815910 |
| 133 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.17487802 |
| 134 | synaptic vesicle endocytosis (GO:0048488) | 2.16947800 |
| 135 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.16419545 |
| 136 | regulation of neurotransmitter levels (GO:0001505) | 2.15071092 |
| 137 | dicarboxylic acid biosynthetic process (GO:0043650) | 2.14406428 |
| 138 | long-term memory (GO:0007616) | 2.13496307 |
| 139 | dendritic spine organization (GO:0097061) | 2.12481907 |
| 140 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 2.11985660 |
| 141 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.11547665 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.37034062 |
| 2 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.54086992 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.46651852 |
| 4 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.39490943 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.37257822 |
| 6 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.28430067 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.28430067 |
| 8 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.22992525 |
| 9 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.13643419 |
| 10 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.12682834 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.09969017 |
| 12 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.08555875 |
| 13 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.07828523 |
| 14 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.01823108 |
| 15 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.99781071 |
| 16 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.98594792 |
| 17 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.98088763 |
| 18 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.94429358 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.79944136 |
| 20 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.79625883 |
| 21 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.78990155 |
| 22 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.77574786 |
| 23 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.74472718 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.72321711 |
| 25 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.72101344 |
| 26 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.70577479 |
| 27 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.68929998 |
| 28 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.67245587 |
| 29 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.66771918 |
| 30 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.65690803 |
| 31 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.64897272 |
| 32 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.61821992 |
| 33 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.60701522 |
| 34 | * FUS_26573619_Chip-Seq_HEK293_Human | 1.60437049 |
| 35 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.58522345 |
| 36 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.54626816 |
| 37 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.52360257 |
| 38 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.48945344 |
| 39 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.48368207 |
| 40 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.47555307 |
| 41 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.47172486 |
| 42 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.44485358 |
| 43 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.44038238 |
| 44 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.43718392 |
| 45 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.42114554 |
| 46 | KDM2B_26808549_Chip-Seq_K562_Human | 1.41561210 |
| 47 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.38373873 |
| 48 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.37668459 |
| 49 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.36595858 |
| 50 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.36215310 |
| 51 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.35586536 |
| 52 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.35346932 |
| 53 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.35120650 |
| 54 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.31968598 |
| 55 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.31165416 |
| 56 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.30519079 |
| 57 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.30241662 |
| 58 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.29483648 |
| 59 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.28806752 |
| 60 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.28522807 |
| 61 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.26978157 |
| 62 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.25531509 |
| 63 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.24171760 |
| 64 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.23914726 |
| 65 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.23120571 |
| 66 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22182571 |
| 67 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.22182571 |
| 68 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.21878791 |
| 69 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.21647822 |
| 70 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.21592337 |
| 71 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.21467085 |
| 72 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.21169508 |
| 73 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.21040641 |
| 74 | TP53_16413492_ChIP-PET_HCT116_Human | 1.20467912 |
| 75 | * BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.20278466 |
| 76 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.20141146 |
| 77 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.19197221 |
| 78 | AR_19668381_ChIP-Seq_PC3_Human | 1.18065951 |
| 79 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.17947115 |
| 80 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.16579595 |
| 81 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.16205258 |
| 82 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14829739 |
| 83 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.14261536 |
| 84 | * NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.13908884 |
| 85 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.13626067 |
| 86 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.13539583 |
| 87 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.13303670 |
| 88 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.12511317 |
| 89 | KDM2B_26808549_Chip-Seq_REH_Human | 1.12134714 |
| 90 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.11451933 |
| 91 | * SOX9_26525672_Chip-Seq_HEART_Mouse | 1.11252492 |
| 92 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.10953817 |
| 93 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.10477887 |
| 94 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.10096133 |
| 95 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.09735068 |
| 96 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.09361996 |
| 97 | RXR_22108803_ChIP-Seq_LS180_Human | 1.08691547 |
| 98 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.07849727 |
| 99 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.07735632 |
| 100 | * CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.07689702 |
| 101 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.06778684 |
| 102 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.06689627 |
| 103 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.06562164 |
| 104 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.06160403 |
| 105 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.05532711 |
| 106 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.04981792 |
| 107 | AR_25329375_ChIP-Seq_VCAP_Human | 1.04454391 |
| 108 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.03594388 |
| 109 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.02786397 |
| 110 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.02623675 |
| 111 | STAT3_23295773_ChIP-Seq_U87_Human | 1.02620739 |
| 112 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.02540092 |
| 113 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.02540092 |
| 114 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.01946100 |
| 115 | * NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.01610493 |
| 116 | * NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.01610493 |
| 117 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.01139293 |
| 118 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.00865351 |
| 119 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.99266134 |
| 120 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.98679930 |
| 121 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.97064856 |
| 122 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.96775782 |
| 123 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.96705170 |
| 124 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.96459189 |
| 125 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.95058552 |
| 126 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.94790611 |
| 127 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.94329812 |
| 128 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.94207476 |
| 129 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.94165244 |
| 130 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.94164257 |
| 131 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.93576007 |
| 132 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.91248518 |
| 133 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.89607653 |
| 134 | P300_19829295_ChIP-Seq_ESCs_Human | 0.89564024 |
| 135 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.89262451 |
| 136 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.88961149 |
| 137 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88415025 |
| 138 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.87456035 |
| 139 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.87265002 |
| 140 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.86314251 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.44812857 |
| 2 | MP0004270_analgesia | 3.38161378 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.06262592 |
| 4 | MP0000569_abnormal_digit_pigmentation | 3.03723275 |
| 5 | MP0004858_abnormal_nervous_system | 3.03243324 |
| 6 | MP0009780_abnormal_chondrocyte_physiolo | 2.72651323 |
| 7 | MP0010234_abnormal_vibrissa_follicle | 2.58598281 |
| 8 | MP0003880_abnormal_central_pattern | 2.50483551 |
| 9 | MP0002063_abnormal_learning/memory/cond | 2.43039077 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.42153459 |
| 11 | MP0003705_abnormal_hypodermis_morpholog | 2.33735784 |
| 12 | MP0002735_abnormal_chemical_nociception | 2.17445868 |
| 13 | MP0009745_abnormal_behavioral_response | 2.16249446 |
| 14 | MP0002734_abnormal_mechanical_nocicepti | 2.15416227 |
| 15 | MP0002822_catalepsy | 2.14828895 |
| 16 | MP0009046_muscle_twitch | 2.00732327 |
| 17 | MP0002064_seizures | 1.90629354 |
| 18 | MP0003329_amyloid_beta_deposits | 1.85930342 |
| 19 | MP0001984_abnormal_olfaction | 1.85124136 |
| 20 | MP0005646_abnormal_pituitary_gland | 1.80512529 |
| 21 | MP0002733_abnormal_thermal_nociception | 1.74480803 |
| 22 | MP0003787_abnormal_imprinting | 1.73097066 |
| 23 | MP0002736_abnormal_nociception_after | 1.72590647 |
| 24 | MP0002572_abnormal_emotion/affect_behav | 1.67833241 |
| 25 | MP0002909_abnormal_adrenal_gland | 1.64134325 |
| 26 | MP0005623_abnormal_meninges_morphology | 1.56456723 |
| 27 | MP0000778_abnormal_nervous_system | 1.55755543 |
| 28 | MP0004811_abnormal_neuron_physiology | 1.50581833 |
| 29 | MP0001970_abnormal_pain_threshold | 1.47788831 |
| 30 | MP0002184_abnormal_innervation | 1.44368175 |
| 31 | MP0005360_urolithiasis | 1.43876837 |
| 32 | MP0001348_abnormal_lacrimal_gland | 1.43116557 |
| 33 | MP0001440_abnormal_grooming_behavior | 1.43004370 |
| 34 | MP0001486_abnormal_startle_reflex | 1.40907333 |
| 35 | MP0004130_abnormal_muscle_cell | 1.40852356 |
| 36 | MP0002272_abnormal_nervous_system | 1.40102277 |
| 37 | MP0001501_abnormal_sleep_pattern | 1.36479755 |
| 38 | MP0003690_abnormal_glial_cell | 1.36096533 |
| 39 | MP0002638_abnormal_pupillary_reflex | 1.35392209 |
| 40 | MP0002254_reproductive_system_inflammat | 1.35336989 |
| 41 | MP0008438_abnormal_cutaneous_collagen | 1.35271197 |
| 42 | MP0005187_abnormal_penis_morphology | 1.31756539 |
| 43 | MP0003045_fibrosis | 1.31709247 |
| 44 | MP0003283_abnormal_digestive_organ | 1.31682991 |
| 45 | MP0005423_abnormal_somatic_nervous | 1.31270679 |
| 46 | MP0000751_myopathy | 1.28687395 |
| 47 | MP0004742_abnormal_vestibular_system | 1.26058600 |
| 48 | MP0000955_abnormal_spinal_cord | 1.25307248 |
| 49 | MP0008961_abnormal_basal_metabolism | 1.23571991 |
| 50 | MP0008569_lethality_at_weaning | 1.21209611 |
| 51 | MP0000604_amyloidosis | 1.20119415 |
| 52 | MP0002067_abnormal_sensory_capabilities | 1.19974732 |
| 53 | MP0005551_abnormal_eye_electrophysiolog | 1.19098086 |
| 54 | MP0003123_paternal_imprinting | 1.18740165 |
| 55 | MP0001177_atelectasis | 1.18209639 |
| 56 | MP0003879_abnormal_hair_cell | 1.17911795 |
| 57 | MP0005645_abnormal_hypothalamus_physiol | 1.17663310 |
| 58 | MP0003633_abnormal_nervous_system | 1.16800300 |
| 59 | MP0005275_abnormal_skin_tensile | 1.16457263 |
| 60 | MP0002229_neurodegeneration | 1.15054030 |
| 61 | MP0001299_abnormal_eye_distance/ | 1.14880905 |
| 62 | MP0003252_abnormal_bile_duct | 1.14626141 |
| 63 | MP0005386_behavior/neurological_phenoty | 1.10412810 |
| 64 | MP0004924_abnormal_behavior | 1.10412810 |
| 65 | MP0000534_abnormal_ureter_morphology | 1.09582592 |
| 66 | MP0001485_abnormal_pinna_reflex | 1.08875181 |
| 67 | MP0004510_myositis | 1.08391495 |
| 68 | MP0003121_genomic_imprinting | 1.06147962 |
| 69 | MP0002837_dystrophic_cardiac_calcinosis | 1.05786652 |
| 70 | MP0000537_abnormal_urethra_morphology | 1.05184983 |
| 71 | MP0004885_abnormal_endolymph | 1.03395388 |
| 72 | MP0000920_abnormal_myelination | 1.01810063 |
| 73 | MP0005167_abnormal_blood-brain_barrier | 1.01172387 |
| 74 | MP0002882_abnormal_neuron_morphology | 0.99314713 |
| 75 | MP0000013_abnormal_adipose_tissue | 0.99186021 |
| 76 | MP0001958_emphysema | 0.98497786 |
| 77 | MP0003890_abnormal_embryonic-extraembry | 0.98259790 |
| 78 | MP0005085_abnormal_gallbladder_physiolo | 0.97493193 |
| 79 | MP0004272_abnormal_basement_membrane | 0.96441984 |
| 80 | MP0004147_increased_porphyrin_level | 0.95710269 |
| 81 | MP0002557_abnormal_social/conspecific_i | 0.95049017 |
| 82 | MP0002090_abnormal_vision | 0.93654592 |
| 83 | MP0001188_hyperpigmentation | 0.92357098 |
| 84 | MP0003631_nervous_system_phenotype | 0.91844742 |
| 85 | MP0005248_abnormal_Harderian_gland | 0.91274730 |
| 86 | MP0003634_abnormal_glial_cell | 0.90491489 |
| 87 | MP0001963_abnormal_hearing_physiology | 0.90277213 |
| 88 | MP0003091_abnormal_cell_migration | 0.90217704 |
| 89 | MP0004043_abnormal_pH_regulation | 0.89662316 |
| 90 | MP0005253_abnormal_eye_physiology | 0.89250540 |
| 91 | MP0002066_abnormal_motor_capabilities/c | 0.89238907 |
| 92 | MP0002139_abnormal_hepatobiliary_system | 0.89002274 |
| 93 | MP0001529_abnormal_vocalization | 0.88675141 |
| 94 | MP0006276_abnormal_autonomic_nervous | 0.87985217 |
| 95 | MP0000631_abnormal_neuroendocrine_gland | 0.87715656 |
| 96 | MP0008877_abnormal_DNA_methylation | 0.86721863 |
| 97 | MP0003075_altered_response_to | 0.86283377 |
| 98 | MP0003122_maternal_imprinting | 0.86165579 |
| 99 | MP0002896_abnormal_bone_mineralization | 0.85310426 |
| 100 | MP0002752_abnormal_somatic_nervous | 0.85098901 |
| 101 | MP0010386_abnormal_urinary_bladder | 0.83698159 |
| 102 | MP0005076_abnormal_cell_differentiation | 0.82805222 |
| 103 | MP0010329_abnormal_lipoprotein_level | 0.82527999 |
| 104 | MP0004233_abnormal_muscle_weight | 0.81484996 |
| 105 | MP0003300_gastrointestinal_ulcer | 0.77023157 |
| 106 | MP0001905_abnormal_dopamine_level | 0.76270050 |
| 107 | MP0004484_altered_response_of | 0.75467154 |
| 108 | MP0002152_abnormal_brain_morphology | 0.74548858 |
| 109 | MP0003137_abnormal_impulse_conducting | 0.73919508 |
| 110 | MP0001502_abnormal_circadian_rhythm | 0.71382369 |
| 111 | MP0008874_decreased_physiological_sensi | 0.70988522 |
| 112 | MP0002138_abnormal_hepatobiliary_system | 0.70805869 |
| 113 | MP0004085_abnormal_heartbeat | 0.70551265 |
| 114 | MP0004142_abnormal_muscle_tone | 0.69835938 |
| 115 | MP0002089_abnormal_postnatal_growth/wei | 0.68993599 |
| 116 | MP0005535_abnormal_body_temperature | 0.68503613 |
| 117 | MP0004185_abnormal_adipocyte_glucose | 0.68362109 |
| 118 | MP0003861_abnormal_nervous_system | 0.68114298 |
| 119 | MP0006138_congestive_heart_failure | 0.67539873 |
| 120 | MP0008057_abnormal_DNA_replication | 0.67103274 |
| 121 | MP0003385_abnormal_body_wall | 0.67046015 |
| 122 | MP0005365_abnormal_bile_salt | 0.66614399 |
| 123 | MP0002069_abnormal_eating/drinking_beha | 0.66282746 |
| 124 | MP0010769_abnormal_survival | 0.65669901 |
| 125 | MP0004215_abnormal_myocardial_fiber | 0.64596396 |
| 126 | MP0003632_abnormal_nervous_system | 0.64033862 |
| 127 | MP0010770_preweaning_lethality | 0.63761381 |
| 128 | MP0002082_postnatal_lethality | 0.63761381 |
| 129 | MP0002295_abnormal_pulmonary_circulatio | 0.63538235 |
| 130 | MP0002108_abnormal_muscle_morphology | 0.63401984 |
| 131 | MP0010768_mortality/aging | 0.62998688 |
| 132 | MP0008872_abnormal_physiological_respon | 0.62708403 |
| 133 | MP0010352_gastrointestinal_tract_polyps | 0.61325551 |
| 134 | MP0003119_abnormal_digestive_system | 0.59859593 |
| 135 | MP0000639_abnormal_adrenal_gland | 0.59243078 |
| 136 | MP0001943_abnormal_respiration | 0.54899333 |
| 137 | MP0006072_abnormal_retinal_apoptosis | 0.54089357 |
| 138 | MP0000462_abnormal_digestive_system | 0.51208972 |
| 139 | MP0002751_abnormal_autonomic_nervous | 0.50516394 |
| 140 | MP0000026_abnormal_inner_ear | 0.50208526 |
| 141 | MP0002081_perinatal_lethality | 0.48718845 |
| 142 | MP0004145_abnormal_muscle_electrophysio | 0.47983705 |
| 143 | MP0005174_abnormal_tail_pigmentation | 0.47929040 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hyperventilation (HP:0002883) | 5.06831361 |
| 2 | Myokymia (HP:0002411) | 4.18276131 |
| 3 | Broad-based gait (HP:0002136) | 4.01056370 |
| 4 | Focal motor seizures (HP:0011153) | 3.64508726 |
| 5 | Focal seizures (HP:0007359) | 3.48504450 |
| 6 | Action tremor (HP:0002345) | 3.44838075 |
| 7 | Scanning speech (HP:0002168) | 3.10658186 |
| 8 | Visual hallucinations (HP:0002367) | 2.98779384 |
| 9 | Protruding tongue (HP:0010808) | 2.90763968 |
| 10 | Status epilepticus (HP:0002133) | 2.87673446 |
| 11 | Hemiparesis (HP:0001269) | 2.84848160 |
| 12 | Termporal pattern (HP:0011008) | 2.83573906 |
| 13 | Insidious onset (HP:0003587) | 2.83573906 |
| 14 | Supranuclear gaze palsy (HP:0000605) | 2.79244967 |
| 15 | Impaired smooth pursuit (HP:0007772) | 2.67527940 |
| 16 | Abnormality of binocular vision (HP:0011514) | 2.60178488 |
| 17 | Diplopia (HP:0000651) | 2.60178488 |
| 18 | Progressive cerebellar ataxia (HP:0002073) | 2.52778906 |
| 19 | Papilledema (HP:0001085) | 2.51510489 |
| 20 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.49611564 |
| 21 | Abnormality of the lower motor neuron (HP:0002366) | 2.48032107 |
| 22 | Epileptic encephalopathy (HP:0200134) | 2.46477750 |
| 23 | Atonic seizures (HP:0010819) | 2.43386112 |
| 24 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.41717522 |
| 25 | Fetal akinesia sequence (HP:0001989) | 2.41280798 |
| 26 | Shallow orbits (HP:0000586) | 2.39838894 |
| 27 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.37987419 |
| 28 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.37987419 |
| 29 | Macroorchidism (HP:0000053) | 2.37548052 |
| 30 | Absence seizures (HP:0002121) | 2.36995623 |
| 31 | Absent speech (HP:0001344) | 2.33297121 |
| 32 | Lymphangioma (HP:0100764) | 2.32527251 |
| 33 | Impaired vibratory sensation (HP:0002495) | 2.32315078 |
| 34 | Limb dystonia (HP:0002451) | 2.28046347 |
| 35 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.27095001 |
| 36 | Febrile seizures (HP:0002373) | 2.26897587 |
| 37 | Hepatoblastoma (HP:0002884) | 2.24431330 |
| 38 | Urinary urgency (HP:0000012) | 2.23748951 |
| 39 | Broad metatarsal (HP:0001783) | 2.23641745 |
| 40 | Ankle clonus (HP:0011448) | 2.23514444 |
| 41 | Inability to walk (HP:0002540) | 2.22834677 |
| 42 | Torticollis (HP:0000473) | 2.22337880 |
| 43 | Abnormal social behavior (HP:0012433) | 2.18529042 |
| 44 | Impaired social interactions (HP:0000735) | 2.18529042 |
| 45 | Cerebral inclusion bodies (HP:0100314) | 2.17751509 |
| 46 | Genetic anticipation (HP:0003743) | 2.17680795 |
| 47 | Generalized tonic-clonic seizures (HP:0002069) | 2.17293241 |
| 48 | Subacute progressive viral hepatitis (HP:0006572) | 2.17135711 |
| 49 | Turricephaly (HP:0000262) | 2.12668718 |
| 50 | Enlarged penis (HP:0000040) | 2.12638293 |
| 51 | Pheochromocytoma (HP:0002666) | 2.10953252 |
| 52 | Buphthalmos (HP:0000557) | 2.09104611 |
| 53 | Papillary thyroid carcinoma (HP:0002895) | 2.06969035 |
| 54 | Hypoventilation (HP:0002791) | 2.06696177 |
| 55 | Dysmetric saccades (HP:0000641) | 2.06429545 |
| 56 | Abnormality of macular pigmentation (HP:0008002) | 2.05077852 |
| 57 | Astrocytoma (HP:0009592) | 2.03551125 |
| 58 | Abnormality of the astrocytes (HP:0100707) | 2.03551125 |
| 59 | Postural instability (HP:0002172) | 2.02704243 |
| 60 | Depression (HP:0000716) | 2.01344017 |
| 61 | Poor eye contact (HP:0000817) | 1.99621862 |
| 62 | Mitral valve prolapse (HP:0001634) | 1.99469131 |
| 63 | Cutaneous finger syndactyly (HP:0010554) | 1.99037479 |
| 64 | Hemiplegia (HP:0002301) | 1.98816964 |
| 65 | Amblyopia (HP:0000646) | 1.97163684 |
| 66 | Long toe (HP:0010511) | 1.96490492 |
| 67 | Lower limb amyotrophy (HP:0007210) | 1.96420508 |
| 68 | Ventricular fibrillation (HP:0001663) | 1.96213503 |
| 69 | Short chin (HP:0000331) | 1.95001047 |
| 70 | Dialeptic seizures (HP:0011146) | 1.94716488 |
| 71 | Excessive salivation (HP:0003781) | 1.94641474 |
| 72 | Drooling (HP:0002307) | 1.94641474 |
| 73 | Overgrowth (HP:0001548) | 1.93878404 |
| 74 | Hypercortisolism (HP:0001578) | 1.92701748 |
| 75 | Spastic tetraplegia (HP:0002510) | 1.92209009 |
| 76 | Akinesia (HP:0002304) | 1.91559001 |
| 77 | Central scotoma (HP:0000603) | 1.91505101 |
| 78 | Cerebral aneurysm (HP:0004944) | 1.91356209 |
| 79 | Pointed chin (HP:0000307) | 1.91085629 |
| 80 | Megalencephaly (HP:0001355) | 1.90146224 |
| 81 | Blue irides (HP:0000635) | 1.89061587 |
| 82 | Elfin facies (HP:0004428) | 1.88509695 |
| 83 | Dysdiadochokinesis (HP:0002075) | 1.87876470 |
| 84 | Bradykinesia (HP:0002067) | 1.87625304 |
| 85 | Insomnia (HP:0100785) | 1.86008740 |
| 86 | Anxiety (HP:0000739) | 1.85844935 |
| 87 | Neurofibrillary tangles (HP:0002185) | 1.85240147 |
| 88 | Abnormality of the corticospinal tract (HP:0002492) | 1.84955006 |
| 89 | Focal dystonia (HP:0004373) | 1.84111258 |
| 90 | Ankyloglossia (HP:0010296) | 1.83759196 |
| 91 | Prolonged QT interval (HP:0001657) | 1.83453021 |
| 92 | Deep venous thrombosis (HP:0002625) | 1.83446019 |
| 93 | Hyperacusis (HP:0010780) | 1.83378931 |
| 94 | Hammertoe (HP:0001765) | 1.83223487 |
| 95 | Mutism (HP:0002300) | 1.81993405 |
| 96 | Hamartoma of the eye (HP:0010568) | 1.81089678 |
| 97 | Generalized hypopigmentation of hair (HP:0011358) | 1.81043272 |
| 98 | Truncal ataxia (HP:0002078) | 1.80980943 |
| 99 | Intention tremor (HP:0002080) | 1.80936627 |
| 100 | Abnormality of salivation (HP:0100755) | 1.79375767 |
| 101 | Syncope (HP:0001279) | 1.79044096 |
| 102 | Agnosia (HP:0010524) | 1.78931265 |
| 103 | Protrusio acetabuli (HP:0003179) | 1.78326852 |
| 104 | Craniofacial dystonia (HP:0012179) | 1.77335712 |
| 105 | Bronchomalacia (HP:0002780) | 1.77055214 |
| 106 | Striae distensae (HP:0001065) | 1.76441682 |
| 107 | Increased circulating renin level (HP:0000848) | 1.75117581 |
| 108 | Upper limb amyotrophy (HP:0009129) | 1.74608646 |
| 109 | Distal upper limb amyotrophy (HP:0007149) | 1.74608646 |
| 110 | Polyphagia (HP:0002591) | 1.74250590 |
| 111 | Bowel diverticulosis (HP:0005222) | 1.74001044 |
| 112 | Abnormal eating behavior (HP:0100738) | 1.73562735 |
| 113 | Thickened helices (HP:0000391) | 1.73406427 |
| 114 | Lower limb muscle weakness (HP:0007340) | 1.73097930 |
| 115 | Aqueductal stenosis (HP:0002410) | 1.71941227 |
| 116 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.70687938 |
| 117 | Dysmetria (HP:0001310) | 1.69073283 |
| 118 | Lower limb asymmetry (HP:0100559) | 1.69028283 |
| 119 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.68687704 |
| 120 | Abnormality of the Achilles tendon (HP:0005109) | 1.68467907 |
| 121 | Dilatation of the ascending aorta (HP:0005111) | 1.68460449 |
| 122 | Renovascular hypertension (HP:0100817) | 1.66854989 |
| 123 | Aplasia involving bones of the extremities (HP:0009825) | 1.66790468 |
| 124 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.66790468 |
| 125 | Aplasia of the phalanges of the hand (HP:0009802) | 1.66790468 |
| 126 | Gastroesophageal reflux (HP:0002020) | 1.66714458 |
| 127 | Tetraplegia (HP:0002445) | 1.66309843 |
| 128 | Resting tremor (HP:0002322) | 1.66228196 |
| 129 | Agitation (HP:0000713) | 1.65818341 |
| 130 | Spastic tetraparesis (HP:0001285) | 1.65791702 |
| 131 | Bundle branch block (HP:0011710) | 1.65450755 |
| 132 | Inappropriate behavior (HP:0000719) | 1.64941770 |
| 133 | Achilles tendon contracture (HP:0001771) | 1.64487669 |
| 134 | Cutaneous syndactyly (HP:0012725) | 1.64386733 |
| 135 | Hypoplasia of the corpus callosum (HP:0002079) | 1.64045124 |
| 136 | Bladder diverticulum (HP:0000015) | 1.63915164 |
| 137 | Epileptiform EEG discharges (HP:0011182) | 1.62873633 |
| 138 | EEG with generalized epileptiform discharges (HP:0011198) | 1.62284236 |
| 139 | Spastic gait (HP:0002064) | 1.61674409 |
| 140 | Postural tremor (HP:0002174) | 1.61140457 |
| 141 | Sleep apnea (HP:0010535) | 1.60765002 |
| 142 | Exotropia (HP:0000577) | 1.60597512 |
| 143 | Gaze-evoked nystagmus (HP:0000640) | 1.59873151 |
| 144 | Hand muscle atrophy (HP:0009130) | 1.59724990 |
| 145 | Neuroendocrine neoplasm (HP:0100634) | 1.58832221 |
| 146 | Aneurysm (HP:0002617) | 1.58159806 |
| 147 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.57497996 |
| 148 | Hypsarrhythmia (HP:0002521) | 1.57436107 |
| 149 | Arterial tortuosity (HP:0005116) | 1.56984183 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 5.85357665 |
| 2 | MAP3K9 | 3.47586547 |
| 3 | NTRK3 | 3.08302397 |
| 4 | MARK1 | 2.83459846 |
| 5 | NTRK1 | 2.62650468 |
| 6 | KSR2 | 2.57000971 |
| 7 | EPHA4 | 2.56418737 |
| 8 | DAPK2 | 2.43685288 |
| 9 | MAP3K4 | 2.29017662 |
| 10 | RIPK1 | 2.24668348 |
| 11 | PAK6 | 2.23238255 |
| 12 | MINK1 | 2.14383928 |
| 13 | MAP3K2 | 1.97114644 |
| 14 | TRIB3 | 1.93306110 |
| 15 | LATS2 | 1.87737209 |
| 16 | LMTK2 | 1.86861407 |
| 17 | CAMKK1 | 1.80313857 |
| 18 | PRKD3 | 1.76595683 |
| 19 | CCNB1 | 1.75373178 |
| 20 | PINK1 | 1.73981557 |
| 21 | RET | 1.70957132 |
| 22 | AKT3 | 1.63581212 |
| 23 | MAP2K4 | 1.59635944 |
| 24 | KSR1 | 1.56807758 |
| 25 | PDGFRA | 1.49217633 |
| 26 | FRK | 1.45821039 |
| 27 | UHMK1 | 1.44703321 |
| 28 | CAMK2B | 1.43964317 |
| 29 | PKN2 | 1.38124108 |
| 30 | DDR2 | 1.36782103 |
| 31 | NTRK2 | 1.34377834 |
| 32 | CAMK1 | 1.24853985 |
| 33 | CAMK1G | 1.22374339 |
| 34 | SCYL2 | 1.18175065 |
| 35 | STK38 | 1.16957293 |
| 36 | CDK5 | 1.16695429 |
| 37 | PHKG2 | 1.16481601 |
| 38 | PHKG1 | 1.16481601 |
| 39 | PAK3 | 1.13499596 |
| 40 | FER | 1.13365399 |
| 41 | FGFR2 | 1.10978030 |
| 42 | PNCK | 1.10681985 |
| 43 | PTK6 | 1.07766679 |
| 44 | RIPK4 | 1.06291818 |
| 45 | SIK2 | 1.05135640 |
| 46 | MAP2K7 | 1.03324106 |
| 47 | CAMK1D | 1.00502895 |
| 48 | TYRO3 | 0.99776803 |
| 49 | OXSR1 | 0.98430154 |
| 50 | MAP3K13 | 0.97663237 |
| 51 | PTK2 | 0.95630379 |
| 52 | SGK3 | 0.95077281 |
| 53 | LATS1 | 0.94668478 |
| 54 | TNIK | 0.92961603 |
| 55 | SIK1 | 0.91968361 |
| 56 | PRKCH | 0.89707107 |
| 57 | GRK5 | 0.88827933 |
| 58 | PLK2 | 0.88550080 |
| 59 | TTN | 0.87639396 |
| 60 | MAP3K7 | 0.86124043 |
| 61 | EPHB2 | 0.86120000 |
| 62 | DAPK1 | 0.85225936 |
| 63 | WNK3 | 0.84948210 |
| 64 | STK11 | 0.83217490 |
| 65 | DMPK | 0.82995602 |
| 66 | TAOK1 | 0.82395641 |
| 67 | MAP2K1 | 0.81724955 |
| 68 | CDK19 | 0.80411067 |
| 69 | MST1R | 0.77345904 |
| 70 | STK39 | 0.76688907 |
| 71 | NEK1 | 0.74929294 |
| 72 | PTK2B | 0.74806721 |
| 73 | CSNK1A1L | 0.74556509 |
| 74 | CSNK1G1 | 0.74259824 |
| 75 | SGK223 | 0.73813112 |
| 76 | SGK494 | 0.73813112 |
| 77 | WNK1 | 0.73148126 |
| 78 | SGK2 | 0.73084408 |
| 79 | EPHA3 | 0.71549083 |
| 80 | PDGFRB | 0.71545490 |
| 81 | PRKCZ | 0.70920311 |
| 82 | FGFR3 | 0.70712194 |
| 83 | BMX | 0.70453280 |
| 84 | DYRK1A | 0.68641794 |
| 85 | PDPK1 | 0.68133618 |
| 86 | SGK1 | 0.67729070 |
| 87 | ALK | 0.65602709 |
| 88 | CAMKK2 | 0.65163575 |
| 89 | ERBB2 | 0.64880599 |
| 90 | CSNK1G3 | 0.64055760 |
| 91 | PDK1 | 0.63481978 |
| 92 | PRKCG | 0.63211324 |
| 93 | MAP3K12 | 0.61164850 |
| 94 | ACVR1B | 0.60106840 |
| 95 | RPS6KA2 | 0.59352427 |
| 96 | MAPK13 | 0.58648255 |
| 97 | CSNK1G2 | 0.58145720 |
| 98 | JAK1 | 0.57421357 |
| 99 | MAP3K1 | 0.55619515 |
| 100 | MAPK10 | 0.55407744 |
| 101 | MARK2 | 0.55020637 |
| 102 | ROCK1 | 0.54353252 |
| 103 | RAF1 | 0.54176670 |
| 104 | CDC42BPA | 0.54070166 |
| 105 | CAMK2G | 0.53192597 |
| 106 | NEK6 | 0.52704390 |
| 107 | MAPK12 | 0.51551484 |
| 108 | CAMK2A | 0.51194490 |
| 109 | CDK14 | 0.50980700 |
| 110 | CSNK1D | 0.50732600 |
| 111 | BMPR1B | 0.49914704 |
| 112 | FGFR1 | 0.48809900 |
| 113 | MAP3K6 | 0.48562124 |
| 114 | CDK11A | 0.48182100 |
| 115 | CDK15 | 0.47934931 |
| 116 | CAMK2D | 0.47772798 |
| 117 | WNK4 | 0.46979320 |
| 118 | FYN | 0.46517125 |
| 119 | PRKCE | 0.46495013 |
| 120 | PIK3CA | 0.45914731 |
| 121 | PKN1 | 0.45795457 |
| 122 | CDK18 | 0.45789864 |
| 123 | BRAF | 0.44600326 |
| 124 | BMPR2 | 0.44297320 |
| 125 | RPS6KA3 | 0.43607605 |
| 126 | ICK | 0.43571601 |
| 127 | PRKG1 | 0.43039616 |
| 128 | MAP3K10 | 0.42046650 |
| 129 | PRKAA1 | 0.41274204 |
| 130 | CAMK4 | 0.40671218 |
| 131 | SRC | 0.39712115 |
| 132 | INSRR | 0.39613296 |
| 133 | PRKCB | 0.37278809 |
| 134 | CSNK1E | 0.35493369 |
| 135 | ARAF | 0.34504357 |
| 136 | CSNK1A1 | 0.32944538 |
| 137 | GSK3B | 0.31980280 |
| 138 | PRKACA | 0.31852953 |
| 139 | PRKCA | 0.31329687 |
| 140 | PRKDC | 0.31185800 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.23304099 |
| 2 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.01305213 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.96087176 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 1.75589376 |
| 5 | Nicotine addiction_Homo sapiens_hsa05033 | 1.75077322 |
| 6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.71953482 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 1.68415970 |
| 8 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.65605892 |
| 9 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.65388145 |
| 10 | Olfactory transduction_Homo sapiens_hsa04740 | 1.63713057 |
| 11 | Salivary secretion_Homo sapiens_hsa04970 | 1.58919175 |
| 12 | GABAergic synapse_Homo sapiens_hsa04727 | 1.56974049 |
| 13 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.53588105 |
| 14 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.49927754 |
| 15 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.45789844 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.45435909 |
| 17 | Renin secretion_Homo sapiens_hsa04924 | 1.43202415 |
| 18 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.41105718 |
| 19 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.40424632 |
| 20 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.40366052 |
| 21 | Insulin secretion_Homo sapiens_hsa04911 | 1.39568825 |
| 22 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.38521162 |
| 23 | Morphine addiction_Homo sapiens_hsa05032 | 1.37932464 |
| 24 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.36345136 |
| 25 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.34651580 |
| 26 | Glioma_Homo sapiens_hsa05214 | 1.32519426 |
| 27 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.31164240 |
| 28 | Bile secretion_Homo sapiens_hsa04976 | 1.26339803 |
| 29 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.24867109 |
| 30 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.24519924 |
| 31 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.22987164 |
| 32 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.15367029 |
| 33 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.14686995 |
| 34 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.13753471 |
| 35 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.10594062 |
| 36 | Gap junction_Homo sapiens_hsa04540 | 1.09984325 |
| 37 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.08490009 |
| 38 | Long-term depression_Homo sapiens_hsa04730 | 1.06405012 |
| 39 | Axon guidance_Homo sapiens_hsa04360 | 1.06085923 |
| 40 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.98378915 |
| 41 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.97794397 |
| 42 | Circadian rhythm_Homo sapiens_hsa04710 | 0.94539131 |
| 43 | Melanogenesis_Homo sapiens_hsa04916 | 0.94039098 |
| 44 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.93371138 |
| 45 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.93312403 |
| 46 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.92937918 |
| 47 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.92498235 |
| 48 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.91365019 |
| 49 | Endometrial cancer_Homo sapiens_hsa05213 | 0.90149595 |
| 50 | Cocaine addiction_Homo sapiens_hsa05030 | 0.89651488 |
| 51 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.88059678 |
| 52 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.87728122 |
| 53 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.87117865 |
| 54 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.85571677 |
| 55 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.84529896 |
| 56 | Taste transduction_Homo sapiens_hsa04742 | 0.84479610 |
| 57 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.79516537 |
| 58 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.77705421 |
| 59 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.77392693 |
| 60 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.77103350 |
| 61 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.77075379 |
| 62 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.76931022 |
| 63 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.74669019 |
| 64 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.74013722 |
| 65 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.73898265 |
| 66 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.72393231 |
| 67 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.71045971 |
| 68 | Focal adhesion_Homo sapiens_hsa04510 | 0.70906850 |
| 69 | Phototransduction_Homo sapiens_hsa04744 | 0.70807877 |
| 70 | Insulin resistance_Homo sapiens_hsa04931 | 0.69572734 |
| 71 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.69248582 |
| 72 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.68724920 |
| 73 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.67678238 |
| 74 | Alcoholism_Homo sapiens_hsa05034 | 0.66875788 |
| 75 | Amoebiasis_Homo sapiens_hsa05146 | 0.66298877 |
| 76 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.65765149 |
| 77 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.65552105 |
| 78 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.65452717 |
| 79 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.64654288 |
| 80 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.64596252 |
| 81 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.62894756 |
| 82 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.62268971 |
| 83 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.61756142 |
| 84 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.61574504 |
| 85 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.61241994 |
| 86 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.59305585 |
| 87 | ABC transporters_Homo sapiens_hsa02010 | 0.58785179 |
| 88 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.58758638 |
| 89 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.56258767 |
| 90 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.55152906 |
| 91 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.54747970 |
| 92 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.54337709 |
| 93 | Adherens junction_Homo sapiens_hsa04520 | 0.53046133 |
| 94 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.53043912 |
| 95 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.52366403 |
| 96 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.49451916 |
| 97 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.49065057 |
| 98 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.48853560 |
| 99 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.47564818 |
| 100 | Prion diseases_Homo sapiens_hsa05020 | 0.47071274 |
| 101 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.46029261 |
| 102 | Endocytosis_Homo sapiens_hsa04144 | 0.46007175 |
| 103 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.45706623 |
| 104 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.45337569 |
| 105 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.45266009 |
| 106 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.44605710 |
| 107 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.44395495 |
| 108 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.43247998 |
| 109 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.42765566 |
| 110 | Tight junction_Homo sapiens_hsa04530 | 0.42383870 |
| 111 | Colorectal cancer_Homo sapiens_hsa05210 | 0.41527162 |
| 112 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.41189876 |
| 113 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.40562705 |
| 114 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.39980238 |
| 115 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.34723079 |
| 116 | Mineral absorption_Homo sapiens_hsa04978 | 0.32138844 |
| 117 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.30289020 |
| 118 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.29760871 |
| 119 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.27289421 |
| 120 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.24844376 |
| 121 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.21076294 |

