ATRX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.67038161
2mitotic sister chromatid cohesion (GO:0007064)5.17321793
3nuclear pore organization (GO:0006999)4.94435542
4presynaptic membrane assembly (GO:0097105)4.67151158
5pore complex assembly (GO:0046931)4.30343517
6histone H3-K4 trimethylation (GO:0080182)4.27913487
7limb bud formation (GO:0060174)4.18293204
8presynaptic membrane organization (GO:0097090)4.10422956
9pyrimidine nucleobase catabolic process (GO:0006208)3.90518630
10histone H3-K4 methylation (GO:0051568)3.89878581
11regulation of DNA endoreduplication (GO:0032875)3.83854615
12protein localization to kinetochore (GO:0034501)3.82303015
13sister chromatid segregation (GO:0000819)3.76695536
14pre-miRNA processing (GO:0031054)3.74933315
15neural tube formation (GO:0001841)3.63792954
16somite development (GO:0061053)3.61763879
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.60125443
18histone H4-K12 acetylation (GO:0043983)3.60005936
19DNA double-strand break processing (GO:0000729)3.56994487
20histone H4-K8 acetylation (GO:0043982)3.49699543
21histone H4-K5 acetylation (GO:0043981)3.49699543
22regulation of telomere maintenance via telomerase (GO:0032210)3.49288146
23polyketide metabolic process (GO:0030638)3.46743563
24doxorubicin metabolic process (GO:0044598)3.46743563
25daunorubicin metabolic process (GO:0044597)3.46743563
26negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.44361346
27mitotic chromosome condensation (GO:0007076)3.44233192
28mitotic sister chromatid segregation (GO:0000070)3.41946002
29peptidyl-lysine trimethylation (GO:0018023)3.41447002
30behavioral response to nicotine (GO:0035095)3.38788305
31histone H3-K9 methylation (GO:0051567)3.29376668
32kinetochore organization (GO:0051383)3.27819120
33histone H4-K16 acetylation (GO:0043984)3.27137953
34negative regulation of histone methylation (GO:0031061)3.22129178
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22023288
36mRNA splice site selection (GO:0006376)3.21672524
37hindbrain development (GO:0030902)3.20291292
38negative regulation of cell cycle G2/M phase transition (GO:1902750)3.16552490
39negative regulation of DNA-dependent DNA replication (GO:2000104)3.16416449
40kidney morphogenesis (GO:0060993)3.16095822
41central nervous system projection neuron axonogenesis (GO:0021952)3.15830906
42* regulation of nuclear cell cycle DNA replication (GO:0033262)3.15382293
43nucleobase catabolic process (GO:0046113)3.14322687
44histone lysine methylation (GO:0034968)3.09892436
45negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.09887331
46postsynaptic membrane organization (GO:0001941)3.08857496
47sister chromatid cohesion (GO:0007062)3.07890125
48olfactory bulb development (GO:0021772)3.05064917
49protein localization to chromosome, centromeric region (GO:0071459)3.02890824
50cerebral cortex radially oriented cell migration (GO:0021799)3.01895470
51otic vesicle formation (GO:0030916)3.01096500
52spinal cord development (GO:0021510)2.92815499
53chromatin assembly (GO:0031497)2.90907873
54neuron recognition (GO:0008038)2.88757585
55intraciliary transport (GO:0042073)2.87928738
56negative regulation of translation, ncRNA-mediated (GO:0040033)2.87376473
57regulation of translation, ncRNA-mediated (GO:0045974)2.87376473
58negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87376473
59protein polyglutamylation (GO:0018095)2.86539913
60nonmotile primary cilium assembly (GO:0035058)2.84351585
61centriole replication (GO:0007099)2.83222293
62neuron cell-cell adhesion (GO:0007158)2.82995700
63response to pheromone (GO:0019236)2.81461319
64regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.80380195
65mechanosensory behavior (GO:0007638)2.79933802
66regulation of histone H3-K9 methylation (GO:0051570)2.78979539
67startle response (GO:0001964)2.78833185
68establishment of protein localization to Golgi (GO:0072600)2.78297102
69axonal fasciculation (GO:0007413)2.78003136
70positive regulation of mitotic sister chromatid separation (GO:1901970)2.77856312
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77856312
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77856312
73kinetochore assembly (GO:0051382)2.76485091
74histone H3-K9 modification (GO:0061647)2.75602569
75protein localization to microtubule cytoskeleton (GO:0072698)2.75148588
76auditory behavior (GO:0031223)2.74990629
77* regulation of telomere maintenance (GO:0032204)2.74712658
78sympathetic nervous system development (GO:0048485)2.74672560
79histone methylation (GO:0016571)2.74015099
80somite rostral/caudal axis specification (GO:0032525)2.73231610
81central nervous system neuron axonogenesis (GO:0021955)2.73143343
82behavioral response to ethanol (GO:0048149)2.71778309
83regulation of meiosis I (GO:0060631)2.70381684
84retinal ganglion cell axon guidance (GO:0031290)2.69264715
85regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69197482
86epithelial cilium movement (GO:0003351)2.69055508
87regulation of helicase activity (GO:0051095)2.68969756
88* DNA geometric change (GO:0032392)2.68654926
89maintenance of protein location in nucleus (GO:0051457)2.68294227
90* DNA duplex unwinding (GO:0032508)2.68199300
91positive regulation of histone H3-K4 methylation (GO:0051571)2.67710743
92regulation of sister chromatid cohesion (GO:0007063)2.67575036
93cilium morphogenesis (GO:0060271)2.66800449
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65263975
95microtubule anchoring (GO:0034453)2.63511664
96transmission of nerve impulse (GO:0019226)2.63406677
97DNA topological change (GO:0006265)2.63126518
98histone H3-K36 demethylation (GO:0070544)2.62445699
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62248293
100interkinetic nuclear migration (GO:0022027)2.61761826
101dosage compensation (GO:0007549)2.61717912
102mRNA stabilization (GO:0048255)2.60275415
103RNA stabilization (GO:0043489)2.60275415
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57705519
105regulation of RNA export from nucleus (GO:0046831)2.57535035
106regulation of double-strand break repair (GO:2000779)2.56571309
107regulation of histone H3-K4 methylation (GO:0051569)2.56385101
108cilium organization (GO:0044782)2.55828128
109negative regulation of epidermis development (GO:0045683)2.55609245
110resolution of meiotic recombination intermediates (GO:0000712)2.55468694
111vocalization behavior (GO:0071625)2.55321518
112DNA replication-dependent nucleosome assembly (GO:0006335)2.55202834
113DNA replication-dependent nucleosome organization (GO:0034723)2.55202834
114stress granule assembly (GO:0034063)2.53163205
115monoubiquitinated protein deubiquitination (GO:0035520)2.53076476
116positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.52889314
117negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.52660179
118negative regulation of dendrite development (GO:2000171)2.52559004
119regulation of centriole replication (GO:0046599)2.51359908
120neuronal action potential (GO:0019228)2.50687071
121forebrain neuron differentiation (GO:0021879)2.50274350
122positive regulation of gene expression, epigenetic (GO:0045815)2.50261231
123protein targeting to Golgi (GO:0000042)2.50138305
124positive regulation of cardiac muscle cell differentiation (GO:2000727)2.49879877
125cilium assembly (GO:0042384)2.49641758
126cell proliferation in forebrain (GO:0021846)2.49621910
127regulation of histone methylation (GO:0031060)2.49484732
128regulation of MHC class I biosynthetic process (GO:0045343)2.47786014
129neuronal action potential propagation (GO:0019227)2.47472126
130appendage development (GO:0048736)2.46619374
131limb development (GO:0060173)2.46619374
132interferon-gamma production (GO:0032609)2.46397189
133regulation of chromatin silencing (GO:0031935)2.46302997
134cytoplasmic mRNA processing body assembly (GO:0033962)2.45923103
135notochord development (GO:0030903)2.45138564
136regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44289627
137cornea development in camera-type eye (GO:0061303)2.44045832
138regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.43683424
139peptidyl-lysine methylation (GO:0018022)2.43631032
140DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.43408343
141atrial cardiac muscle cell action potential (GO:0086014)2.43386146
142protein localization to synapse (GO:0035418)2.42988548
143* regulation of DNA-dependent DNA replication (GO:0090329)2.42963902
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42862100
145* replication fork processing (GO:0031297)2.42822696
146negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41566166
147head development (GO:0060322)2.41564895
148NLS-bearing protein import into nucleus (GO:0006607)2.41464630
149gamma-aminobutyric acid transport (GO:0015812)2.41156906
150heterochromatin organization (GO:0070828)2.41089581
151histone lysine demethylation (GO:0070076)2.40596142
152DNA unwinding involved in DNA replication (GO:0006268)2.39307485
153negative regulation of axon guidance (GO:1902668)2.39106209
154protein localization to chromosome (GO:0034502)2.38644112
155spindle assembly checkpoint (GO:0071173)2.36628011
156membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36535974
157spindle checkpoint (GO:0031577)2.34819396
158* DNA conformation change (GO:0071103)2.33006147
159histone demethylation (GO:0016577)2.32459597
160negative regulation of telomere maintenance (GO:0032205)2.31880288
161retrograde transport, vesicle recycling within Golgi (GO:0000301)2.31833850
162inner ear receptor stereocilium organization (GO:0060122)2.31584311
163histone H3-K9 demethylation (GO:0033169)2.30833617
164chromosome segregation (GO:0007059)2.30507854
165histone mRNA catabolic process (GO:0071044)2.30116645
166negative regulation of chromatin modification (GO:1903309)2.30064935
167histone H4 acetylation (GO:0043967)2.29741193
168regulation of timing of cell differentiation (GO:0048505)2.29517233
169protein localization to cytoskeleton (GO:0044380)2.29318258
170meiotic chromosome segregation (GO:0045132)2.28979898
171serotonin metabolic process (GO:0042428)2.28918973
172axoneme assembly (GO:0035082)2.28907797
173spinal cord motor neuron differentiation (GO:0021522)2.28862255
174regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28425526
175synapsis (GO:0007129)2.27942552
176prenylation (GO:0097354)2.27708133
177protein prenylation (GO:0018342)2.27708133
178regulation of pigment cell differentiation (GO:0050932)2.27373640
179regulation of collateral sprouting (GO:0048670)2.27340082
180regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.26952289
181dendrite morphogenesis (GO:0048813)2.26945414
182recombinational repair (GO:0000725)2.26834760
183synapse assembly (GO:0007416)2.26502658
184dendritic spine morphogenesis (GO:0060997)2.26381242
185cerebral cortex cell migration (GO:0021795)2.26066624
186double-strand break repair via homologous recombination (GO:0000724)2.25613214
187dorsal/ventral axis specification (GO:0009950)2.25524569
188positive regulation of synapse assembly (GO:0051965)2.24954939
189prostate gland growth (GO:0060736)2.23659090
190glutamate receptor signaling pathway (GO:0007215)2.22611349
191neurotransmitter-gated ion channel clustering (GO:0072578)2.22294832
192negative regulation of systemic arterial blood pressure (GO:0003085)2.22269644
193RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.22099274
194retinal cone cell development (GO:0046549)2.22094183
195embryonic epithelial tube formation (GO:0001838)2.20167543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.31887843
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.11012297
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.89497674
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.47214254
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38303074
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07752538
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.76821152
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.76821152
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.76821152
10ZNF274_21170338_ChIP-Seq_K562_Hela2.62584774
11TAF15_26573619_Chip-Seq_HEK293_Human2.58349185
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55853821
13VDR_22108803_ChIP-Seq_LS180_Human2.45283247
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.43962531
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40686668
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40506617
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36940430
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21289311
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19757587
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15865762
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.08117713
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03560019
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02915297
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89975681
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.85066523
26IGF1R_20145208_ChIP-Seq_DFB_Human1.84878052
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84325242
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83136147
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79823679
30* FUS_26573619_Chip-Seq_HEK293_Human1.79177323
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77896253
32GBX2_23144817_ChIP-Seq_PC3_Human1.76499679
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74409316
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.73686180
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73398375
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72978623
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69147591
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.65046381
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.64362257
40ER_23166858_ChIP-Seq_MCF-7_Human1.62152245
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61356466
42EWS_26573619_Chip-Seq_HEK293_Human1.60859729
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60693119
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58763709
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58035018
46BCAT_22108803_ChIP-Seq_LS180_Human1.56796891
47FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.55898105
48CBP_20019798_ChIP-Seq_JUKART_Human1.52665175
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52665175
50AR_25329375_ChIP-Seq_VCAP_Human1.52513723
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50406009
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.48058395
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47579828
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45783352
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45166123
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.44010272
57IRF1_19129219_ChIP-ChIP_H3396_Human1.41373647
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38485387
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38051284
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.35844674
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.35532459
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34017524
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34017524
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33244850
65RNF2_27304074_Chip-Seq_NSC_Mouse1.32759554
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32527445
67RUNX2_22187159_ChIP-Seq_PCA_Human1.30437886
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28762418
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28569993
70P53_22387025_ChIP-Seq_ESCs_Mouse1.25227982
71STAT3_23295773_ChIP-Seq_U87_Human1.25136548
72* TCF4_22108803_ChIP-Seq_LS180_Human1.24081162
73AR_21572438_ChIP-Seq_LNCaP_Human1.23553249
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23356908
75TP53_16413492_ChIP-PET_HCT116_Human1.22908025
76NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22344891
77POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.20941079
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.20814534
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20473758
80REST_21632747_ChIP-Seq_MESCs_Mouse1.20456297
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.20452714
82* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20275037
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19227327
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.19161143
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.18350106
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18331726
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17621718
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17255583
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17052422
90EZH2_22144423_ChIP-Seq_EOC_Human1.16064824
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15517865
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14428139
93* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13956343
94SMAD4_21799915_ChIP-Seq_A2780_Human1.13505052
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13346344
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.11271512
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10507431
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10349457
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10157885
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09808060
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09451910
102KDM2B_26808549_Chip-Seq_REH_Human1.09208169
103JUN_21703547_ChIP-Seq_K562_Human1.09092687
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08901241
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08266431
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08068110
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.07585086
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07474746
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07452746
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06708810
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.05797459
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.05718854
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.05572942
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04694279
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04620383
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04591327
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04548140
118JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04260698
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.03816287
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03750856
121P300_18555785_Chip-Seq_ESCs_Mouse1.03462323
122* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03355048
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02810705
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02737515
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02108269
126AHR_22903824_ChIP-Seq_MCF-7_Human1.02055211
127* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00595371
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.00514376
129P300_19829295_ChIP-Seq_ESCs_Human0.99431818
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99172627
131RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99104235
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98844816
133TCF4_23295773_ChIP-Seq_U87_Human0.98459807
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.97607492
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97101294
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97026345
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.96696066
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96055643
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95550827
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95382278
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91520560
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89709043
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.89351185
144* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89119824
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85384286
146BRD4_25478319_ChIP-Seq_HGPS_Human0.83896216
147STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83085735
148TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82668822
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82495221
150NANOG_16518401_ChIP-PET_MESCs_Mouse0.81971051
151ELK1_19687146_ChIP-ChIP_HELA_Human0.81873259
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81578942
153BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81437617
154RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80775980
155ISL1_27105846_Chip-Seq_CPCs_Mouse0.80659713
156SOX9_26525672_Chip-Seq_HEART_Mouse0.80216713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.92921796
2MP0008057_abnormal_DNA_replication3.64521401
3MP0006292_abnormal_olfactory_placode3.48727830
4MP0003890_abnormal_embryonic-extraembry2.84308671
5* MP0003787_abnormal_imprinting2.76597022
6MP0003880_abnormal_central_pattern2.73622423
7* MP0003121_genomic_imprinting2.71630361
8MP0010094_abnormal_chromosome_stability2.47616522
9MP0002102_abnormal_ear_morphology2.40732283
10MP0004264_abnormal_extraembryonic_tissu2.30601210
11MP0002396_abnormal_hematopoietic_system2.20017368
12MP0003122_maternal_imprinting2.16623259
13MP0005248_abnormal_Harderian_gland2.00864258
14MP0003111_abnormal_nucleus_morphology1.95344993
15MP0001968_abnormal_touch/_nociception1.93040312
16MP0003077_abnormal_cell_cycle1.90512704
17MP0008877_abnormal_DNA_methylation1.84817183
18MP0003123_paternal_imprinting1.82306852
19MP0010352_gastrointestinal_tract_polyps1.81277195
20MP0001984_abnormal_olfaction1.77649016
21MP0004885_abnormal_endolymph1.73709173
22MP0008007_abnormal_cellular_replicative1.73639732
23MP0005394_taste/olfaction_phenotype1.72493092
24MP0005499_abnormal_olfactory_system1.72493092
25MP0001529_abnormal_vocalization1.70048955
26MP0002736_abnormal_nociception_after1.68854797
27MP0008058_abnormal_DNA_repair1.68305343
28MP0002837_dystrophic_cardiac_calcinosis1.67114333
29MP0002735_abnormal_chemical_nociception1.61466429
30* MP0005551_abnormal_eye_electrophysiolog1.54104135
31MP0002009_preneoplasia1.53465280
32MP0001188_hyperpigmentation1.52695170
33MP0006276_abnormal_autonomic_nervous1.52670335
34MP0009745_abnormal_behavioral_response1.52070417
35MP0002234_abnormal_pharynx_morphology1.51898300
36MP0003635_abnormal_synaptic_transmissio1.51451216
37MP0001293_anophthalmia1.49764836
38MP0000427_abnormal_hair_cycle1.48623067
39MP0003937_abnormal_limbs/digits/tail_de1.48162569
40MP0004270_analgesia1.47360929
41MP0002272_abnormal_nervous_system1.47284406
42MP0005367_renal/urinary_system_phenotyp1.44772978
43MP0000516_abnormal_urinary_system1.44772978
44MP0009046_muscle_twitch1.42602252
45MP0001485_abnormal_pinna_reflex1.42216635
46MP0003755_abnormal_palate_morphology1.41598929
47MP0003935_abnormal_craniofacial_develop1.40785100
48MP0005646_abnormal_pituitary_gland1.40686985
49MP0005253_abnormal_eye_physiology1.39568389
50MP0002557_abnormal_social/conspecific_i1.39407249
51* MP0001672_abnormal_embryogenesis/_devel1.35596663
52* MP0005380_embryogenesis_phenotype1.35596663
53MP0002734_abnormal_mechanical_nocicepti1.34905872
54MP0002184_abnormal_innervation1.34845977
55MP0002938_white_spotting1.32425218
56MP0002572_abnormal_emotion/affect_behav1.32337607
57MP0002063_abnormal_learning/memory/cond1.32110320
58* MP0000350_abnormal_cell_proliferation1.32030742
59MP0004859_abnormal_synaptic_plasticity1.30720465
60* MP0004957_abnormal_blastocyst_morpholog1.30654028
61* MP0002084_abnormal_developmental_patter1.27794549
62MP0005075_abnormal_melanosome_morpholog1.26100278
63MP0002277_abnormal_respiratory_mucosa1.25134664
64MP0002085_abnormal_embryonic_tissue1.23470535
65MP0002638_abnormal_pupillary_reflex1.23203836
66* MP0003984_embryonic_growth_retardation1.20734790
67MP0004145_abnormal_muscle_electrophysio1.20474951
68MP0002233_abnormal_nose_morphology1.20059463
69MP0008789_abnormal_olfactory_epithelium1.19920663
70* MP0002088_abnormal_embryonic_growth/wei1.19853916
71MP0003283_abnormal_digestive_organ1.19847139
72MP0000631_abnormal_neuroendocrine_gland1.19659390
73MP0004142_abnormal_muscle_tone1.19298994
74MP0000432_abnormal_head_morphology1.17030101
75MP0000778_abnormal_nervous_system1.16322219
76* MP0005386_behavior/neurological_phenoty1.14144842
77* MP0004924_abnormal_behavior1.14144842
78MP0004197_abnormal_fetal_growth/weight/1.14006646
79MP0002067_abnormal_sensory_capabilities1.11954822
80MP0003938_abnormal_ear_development1.11597175
81MP0002095_abnormal_skin_pigmentation1.11535790
82MP0003119_abnormal_digestive_system1.11533173
83* MP0002086_abnormal_extraembryonic_tissu1.10654218
84MP0002064_seizures1.10579426
85MP0000955_abnormal_spinal_cord1.10446838
86MP0000647_abnormal_sebaceous_gland1.09420972
87MP0002254_reproductive_system_inflammat1.09034489
88MP0003861_abnormal_nervous_system1.08923201
89MP0010307_abnormal_tumor_latency1.08781785
90MP0004808_abnormal_hematopoietic_stem1.08600281
91MP0003693_abnormal_embryo_hatching1.07978348
92MP0004215_abnormal_myocardial_fiber1.07575772
93MP0003195_calcinosis1.07348130
94MP0010030_abnormal_orbit_morphology1.05899294
95MP0001286_abnormal_eye_development1.04856378
96MP0000049_abnormal_middle_ear1.04744815
97MP0000428_abnormal_craniofacial_morphol1.04563189
98* MP0009703_decreased_birth_body1.01614158
99MP0003315_abnormal_perineum_morphology1.01437936
100MP0002822_catalepsy1.01159674
101* MP0002752_abnormal_somatic_nervous1.01075457
102MP0002116_abnormal_craniofacial_bone1.00230962
103MP0002092_abnormal_eye_morphology0.99769775
104MP0005423_abnormal_somatic_nervous0.98371819
105MP0002114_abnormal_axial_skeleton0.97629622
106MP0002877_abnormal_melanocyte_morpholog0.96800996
107* MP0002882_abnormal_neuron_morphology0.96418379
108MP0002163_abnormal_gland_morphology0.95740952
109MP0001986_abnormal_taste_sensitivity0.95217358
110MP0000015_abnormal_ear_pigmentation0.94618274
111MP0001177_atelectasis0.94350687
112MP0005076_abnormal_cell_differentiation0.93998270
113* MP0002152_abnormal_brain_morphology0.93780024
114MP0005645_abnormal_hypothalamus_physiol0.93044505
115MP0005187_abnormal_penis_morphology0.92768447
116MP0001299_abnormal_eye_distance/0.92317956
117MP0001346_abnormal_lacrimal_gland0.91934798
118MP0004742_abnormal_vestibular_system0.91293398
119MP0003941_abnormal_skin_development0.90621421
120MP0005174_abnormal_tail_pigmentation0.90594519
121MP0003385_abnormal_body_wall0.90368965
122MP0002925_abnormal_cardiovascular_devel0.90341197
123MP0000537_abnormal_urethra_morphology0.89947197
124* MP0001697_abnormal_embryo_size0.88870594
125MP0002127_abnormal_cardiovascular_syste0.88842248
126MP0005257_abnormal_intraocular_pressure0.88714557
127MP0000372_irregular_coat_pigmentation0.87691502
128MP0002932_abnormal_joint_morphology0.87371678
129MP0001970_abnormal_pain_threshold0.87204808
130* MP0005195_abnormal_posterior_eye0.86832290
131MP0010386_abnormal_urinary_bladder0.86405508
132MP0002075_abnormal_coat/hair_pigmentati0.86271009
133MP0002081_perinatal_lethality0.86021869
134MP0002876_abnormal_thyroid_physiology0.85645187
135MP0009780_abnormal_chondrocyte_physiolo0.84948798
136MP0000678_abnormal_parathyroid_gland0.84360666
137MP0002733_abnormal_thermal_nociception0.82864204
138MP0002928_abnormal_bile_duct0.82684537
139MP0002160_abnormal_reproductive_system0.80787606
140MP0000703_abnormal_thymus_morphology0.80750040
141MP0000026_abnormal_inner_ear0.80257783
142MP0003942_abnormal_urinary_system0.79462141
143MP0002109_abnormal_limb_morphology0.79165092
144MP0008932_abnormal_embryonic_tissue0.78940065
145MP0009250_abnormal_appendicular_skeleto0.78773240
146MP0001730_embryonic_growth_arrest0.78640250
147MP0001501_abnormal_sleep_pattern0.78553928
148MP0002751_abnormal_autonomic_nervous0.77399247
149MP0005391_vision/eye_phenotype0.77372017
150MP0002177_abnormal_outer_ear0.77057599
151MP0006072_abnormal_retinal_apoptosis0.76092864
152MP0002249_abnormal_larynx_morphology0.75138057
153MP0003183_abnormal_peptide_metabolism0.75029018
154MP0003567_abnormal_fetal_cardiomyocyte0.74577089
155MP0000490_abnormal_crypts_of0.71978751
156MP0000383_abnormal_hair_follicle0.71429549
157MP0005171_absent_coat_pigmentation0.69718702
158MP0004133_heterotaxia0.68392765
159MP0001849_ear_inflammation0.68290498
160MP0001486_abnormal_startle_reflex0.68268553

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.15697138
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12080427
3Hyperventilation (HP:0002883)4.06295390
4Hepatoblastoma (HP:0002884)3.93411101
5* Volvulus (HP:0002580)3.41132237
6Pancreatic cysts (HP:0001737)3.39742530
7Molar tooth sign on MRI (HP:0002419)3.39641053
8Abnormality of midbrain morphology (HP:0002418)3.39641053
9Pancreatic fibrosis (HP:0100732)3.37075683
10True hermaphroditism (HP:0010459)3.32891312
11Nephronophthisis (HP:0000090)3.27508361
12Nephroblastoma (Wilms tumor) (HP:0002667)3.22451967
13Abnormality of the astrocytes (HP:0100707)3.06390588
14Astrocytoma (HP:0009592)3.06390588
15Medial flaring of the eyebrow (HP:0010747)3.00841914
16Embryonal renal neoplasm (HP:0011794)3.00664934
17Medulloblastoma (HP:0002885)2.96690098
18Bilateral microphthalmos (HP:0007633)2.95369199
19Abnormality of the renal medulla (HP:0100957)2.89176252
20Abnormality of the fingertips (HP:0001211)2.87643562
21Ependymoma (HP:0002888)2.85878515
22Papillary thyroid carcinoma (HP:0002895)2.85428749
23Glioma (HP:0009733)2.73051281
24Broad-based gait (HP:0002136)2.69437786
25Gait imbalance (HP:0002141)2.66568396
26Intestinal atresia (HP:0011100)2.66207715
27Lip pit (HP:0100267)2.65897981
28Genital tract atresia (HP:0001827)2.63832202
29Neoplasm of the oral cavity (HP:0100649)2.59531185
30Abnormality of the renal cortex (HP:0011035)2.56626788
31Supernumerary ribs (HP:0005815)2.56016409
32Vaginal atresia (HP:0000148)2.53516584
33Focal seizures (HP:0007359)2.53006880
34Congenital primary aphakia (HP:0007707)2.51273682
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.50900014
36Focal motor seizures (HP:0011153)2.50095645
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.49071623
38Chronic hepatic failure (HP:0100626)2.46202483
39Supernumerary bones of the axial skeleton (HP:0009144)2.46176723
40* Drooling (HP:0002307)2.45024786
41Meckel diverticulum (HP:0002245)2.39770914
42Abnormality of chromosome stability (HP:0003220)2.34916427
43Abnormality of chromosome segregation (HP:0002916)2.34463857
44Renal cortical cysts (HP:0000803)2.34069728
45Abnormality of the ileum (HP:0001549)2.31322539
46Febrile seizures (HP:0002373)2.30636710
47Rhabdomyosarcoma (HP:0002859)2.27416421
48Neoplasm of striated muscle (HP:0009728)2.27303127
49Abnormality of the labia minora (HP:0012880)2.26866649
50Nephrogenic diabetes insipidus (HP:0009806)2.25638317
51Progressive cerebellar ataxia (HP:0002073)2.25017597
52Embryonal neoplasm (HP:0002898)2.24041042
53Short 4th metacarpal (HP:0010044)2.23802633
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23802633
55Gaze-evoked nystagmus (HP:0000640)2.22236572
56Increased nuchal translucency (HP:0010880)2.22223825
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.21384534
58Neoplasm of the adrenal cortex (HP:0100641)2.21265286
59Macroorchidism (HP:0000053)2.20856261
60Cystic liver disease (HP:0006706)2.20670857
61Transitional cell carcinoma of the bladder (HP:0006740)2.19404373
62Ectopic kidney (HP:0000086)2.18156550
63Colon cancer (HP:0003003)2.17850335
64Leiomyosarcoma (HP:0100243)2.17519190
65Uterine leiomyosarcoma (HP:0002891)2.17519190
66Deep philtrum (HP:0002002)2.16941156
67Abnormality of the nasal septum (HP:0000419)2.15568748
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.15265386
69* Excessive salivation (HP:0003781)2.15112094
70Aqueductal stenosis (HP:0002410)2.12896719
71Postaxial hand polydactyly (HP:0001162)2.10886513
72Atonic seizures (HP:0010819)2.10853133
73Rib fusion (HP:0000902)2.09404013
74Congenital stationary night blindness (HP:0007642)2.05290578
75Poor coordination (HP:0002370)2.04785751
76Optic nerve hypoplasia (HP:0000609)2.03404728
77Genetic anticipation (HP:0003743)2.01239636
78Fair hair (HP:0002286)2.00769635
79* Narrow forehead (HP:0000341)1.99604665
80Abnormal lung lobation (HP:0002101)1.99552663
81Abnormality of the preputium (HP:0100587)1.99461353
82Small hand (HP:0200055)1.98729966
83Cupped ear (HP:0000378)1.97556889
84Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96959933
85Duodenal stenosis (HP:0100867)1.95789148
86Small intestinal stenosis (HP:0012848)1.95789148
87Long eyelashes (HP:0000527)1.95691935
88Postaxial foot polydactyly (HP:0001830)1.95362527
89Anencephaly (HP:0002323)1.94373959
90Abnormality of the ischium (HP:0003174)1.94139507
91Dialeptic seizures (HP:0011146)1.93745986
92Lissencephaly (HP:0001339)1.93636082
93Truncal obesity (HP:0001956)1.91648215
94Sclerocornea (HP:0000647)1.91289583
95Thyroid carcinoma (HP:0002890)1.90869242
96Obsessive-compulsive behavior (HP:0000722)1.90233196
97Septo-optic dysplasia (HP:0100842)1.89766743
98Supernumerary spleens (HP:0009799)1.89584916
99Bladder carcinoma (HP:0002862)1.88316806
100Bladder neoplasm (HP:0009725)1.88316806
101Anophthalmia (HP:0000528)1.86739621
102Limb dystonia (HP:0002451)1.86114780
103Gastrointestinal carcinoma (HP:0002672)1.85234527
104Malignant gastrointestinal tract tumors (HP:0006749)1.85234527
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84141496
106Gonadotropin excess (HP:0000837)1.83443441
107Abnormality of the carotid arteries (HP:0005344)1.82732220
108Congenital hepatic fibrosis (HP:0002612)1.82529846
109Hypothermia (HP:0002045)1.82462395
110Hypoplastic labia majora (HP:0000059)1.82177970
111Tubular atrophy (HP:0000092)1.81794731
112Preaxial hand polydactyly (HP:0001177)1.81642288
113Pachygyria (HP:0001302)1.80799670
114Increased number of teeth (HP:0011069)1.79840161
115Subacute progressive viral hepatitis (HP:0006572)1.79767966
116Dandy-Walker malformation (HP:0001305)1.79141885
117Hypoplastic ischia (HP:0003175)1.78820299
118Specific learning disability (HP:0001328)1.78290216
119* Protruding tongue (HP:0010808)1.78081768
120Widely spaced teeth (HP:0000687)1.78067907
121Short foot (HP:0001773)1.77205234
122Impulsivity (HP:0100710)1.77094309
123Gastrointestinal atresia (HP:0002589)1.76507790
124Clubbing of toes (HP:0100760)1.76174582
125Anal stenosis (HP:0002025)1.74841318
126Thyroiditis (HP:0100646)1.74502849
127Aplasia/Hypoplasia of the fovea (HP:0008060)1.74332908
128Hypoplasia of the fovea (HP:0007750)1.74332908
129Hip dysplasia (HP:0001385)1.73309980
130Astigmatism (HP:0000483)1.73198136
131Prominent nose (HP:0000448)1.72933103
132Hemiparesis (HP:0001269)1.72504371
133Heterotopia (HP:0002282)1.71115317
134Renal duplication (HP:0000075)1.69814274
135Abolished electroretinogram (ERG) (HP:0000550)1.69769834
136Intestinal fistula (HP:0100819)1.69560412
137Type II lissencephaly (HP:0007260)1.69216758
138Skin tags (HP:0010609)1.69186017
139Morphological abnormality of the middle ear (HP:0008609)1.69033294
140* Myelodysplasia (HP:0002863)1.68031280
141Smooth philtrum (HP:0000319)1.67274710
142Stomach cancer (HP:0012126)1.66276260
143Labial hypoplasia (HP:0000066)1.65562189
144Malignant neoplasm of the central nervous system (HP:0100836)1.65484077
145Prominent nasal bridge (HP:0000426)1.64962661
146Patellar aplasia (HP:0006443)1.64799897
147Dislocated radial head (HP:0003083)1.63414093
148Abnormality of the duodenum (HP:0002246)1.62951743
149Growth hormone deficiency (HP:0000824)1.62679793
150Cystic hygroma (HP:0000476)1.62532204
151* Micropenis (HP:0000054)1.62462862
152Abnormality of the intervertebral disk (HP:0005108)1.62009143
153Highly arched eyebrow (HP:0002553)1.61801086
154Megalencephaly (HP:0001355)1.61761648
155Abnormal biliary tract physiology (HP:0012439)1.60666385
156Hypoplasia of the maxilla (HP:0000327)1.60479958
157Abnormality of the lower motor neuron (HP:0002366)1.60420495
158Preauricular skin tag (HP:0000384)1.60276156
159Bifid tongue (HP:0010297)1.59814873
160Skin pits (HP:0100276)1.59421222
161Oligodactyly (hands) (HP:0001180)1.58885907
162Curly hair (HP:0002212)1.58838430
163Broad thumb (HP:0011304)1.58624141
164Epileptic encephalopathy (HP:0200134)1.58509400
165Periauricular skin pits (HP:0100277)1.58401395
166Preauricular pit (HP:0004467)1.58401395
167High anterior hairline (HP:0009890)1.58243290
168Abnormality of the labia majora (HP:0012881)1.58209653
169Acute lymphatic leukemia (HP:0006721)1.58017404
170Facial hemangioma (HP:0000329)1.57344909
171Abnormal hair whorl (HP:0010721)1.56416426
172Sloping forehead (HP:0000340)1.56304353
173Broad palm (HP:0001169)1.55619413
174Abnormality of the phalanges of the hallux (HP:0010057)1.55364650
175Acute myeloid leukemia (HP:0004808)1.54871982
176Abnormality of the distal phalanx of the thumb (HP:0009617)1.54156688
177Absent speech (HP:0001344)1.54000343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.44152627
2TNIK3.34779364
3WNK33.10993716
4CDC72.89007738
5LATS12.70063318
6BRD42.29896681
7AKT32.11305571
8TTK2.00494668
9TRIM281.88584625
10SRPK11.88423451
11MAP4K21.87409331
12FGFR31.72321134
13GRK51.71423613
14MKNK21.70470916
15ERBB31.69035035
16NUAK11.65469842
17CHEK21.62650310
18ZAK1.49196793
19SIK21.48952458
20WNK11.45425279
21PAK31.44478094
22NTRK31.39982629
23MAPK71.39555869
24MKNK11.39161090
25ATR1.37249751
26CSF1R1.35410578
27PINK11.33533504
28PLK41.32126929
29CDK71.31921529
30FRK1.31725763
31ATM1.31323794
32MAPK131.31114325
33STK391.30471962
34CHEK11.27807920
35MARK11.27633039
36GRK61.22590214
37YES11.20832332
38NEK21.20475113
39PLK21.19037439
40SGK21.17681082
41PLK31.11640904
42WEE11.11049095
43PLK11.09811575
44DYRK21.08884284
45CAMK41.07122466
46CASK1.06950659
47CAMK1G1.05081475
48ACVR1B1.02005393
49STK31.01901167
50OXSR11.01597356
51EIF2AK31.00886909
52NTRK21.00304033
53CSNK1G10.95659235
54TYRO30.93503124
55PRKCE0.93203208
56ADRBK20.92564670
57HIPK20.92214657
58* CDK20.91742174
59BRSK20.91546819
60CDK80.90442661
61CDK30.89675835
62CHUK0.89093697
63PRPF4B0.89023296
64PNCK0.88227420
65INSRR0.88144595
66CAMK1D0.87425459
67EIF2AK20.86739959
68CDK10.84635926
69SGK30.84120704
70MARK20.83912556
71PRKCG0.83656258
72MINK10.83547402
73FGFR20.81600592
74MAP2K70.81475768
75CSNK1A1L0.80790604
76MAP3K40.78956366
77DYRK1A0.78858874
78CDK90.78752457
79GRK10.78132030
80AURKB0.77910587
81MAP3K60.75972581
82CDK60.75929755
83* MAPK140.74056171
84NLK0.73316660
85PIK3CA0.71438343
86MAPK100.71222729
87GRK70.71082659
88GSK3B0.70255538
89PKN10.69508650
90CSNK1G30.69388887
91SGK2230.68573989
92SGK4940.68573989
93TAOK30.68554610
94BMPR1B0.68330223
95BMPR20.67699180
96STK100.67266486
97MELK0.65193495
98WNK40.62119145
99UHMK10.61765272
100MATK0.61532618
101CAMK2A0.61449201
102STK38L0.60899441
103CSNK1D0.59698442
104PASK0.59435916
105ERBB20.59096047
106PRKD30.58698969
107TEC0.57873555
108OBSCN0.57596161
109PRKDC0.56619592
110ALK0.56448418
111EPHA40.55380056
112MTOR0.55332445
113SIK30.53962009
114LATS20.53916258
115BCR0.53818619
116TIE10.53257245
117TAF10.52742215
118AKT10.52608903
119SGK10.52088284
120CSNK1E0.51151520
121TGFBR20.50550660
122PDGFRB0.50248192
123CDK40.49851004
124ADRBK10.49770384
125NEK60.47904420
126MAPK80.47823680
127MAP2K40.47217573
128VRK10.46798228
129RPS6KB10.44093531
130FGFR10.43352848
131CSNK1G20.43229398
132DYRK30.42441830
133CDK50.42324688
134STK40.42012141
135DMPK0.41636579
136KSR10.41308196
137MAPK10.41134818
138FER0.40487105
139CAMK10.39158862
140CAMKK20.37469063
141TGFBR10.37145296
142PRKACA0.36502295
143PHKG10.36192606
144PHKG20.36192606
145PRKACB0.35958953
146PRKCH0.34813145
147PRKG10.34172233
148CSNK1A10.34096038
149CAMK2B0.32162297
150CCNB10.32096131
151PRKCZ0.30886689
152RPS6KA30.30633852

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69353585
2Protein export_Homo sapiens_hsa030602.46299162
3Propanoate metabolism_Homo sapiens_hsa006402.13162749
4Fanconi anemia pathway_Homo sapiens_hsa034602.03104068
5Non-homologous end-joining_Homo sapiens_hsa034501.90150543
6Butanoate metabolism_Homo sapiens_hsa006501.86274081
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85224850
8Cell cycle_Homo sapiens_hsa041101.75068127
9mRNA surveillance pathway_Homo sapiens_hsa030151.71656755
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70884396
11Steroid biosynthesis_Homo sapiens_hsa001001.67338500
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63224639
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.61168123
14Mismatch repair_Homo sapiens_hsa034301.53649713
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53567424
16MicroRNAs in cancer_Homo sapiens_hsa052061.50118080
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45578473
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41637570
19RNA degradation_Homo sapiens_hsa030181.40867105
20Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39286332
21Insulin secretion_Homo sapiens_hsa049111.37305762
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36488922
23Nicotine addiction_Homo sapiens_hsa050331.35918752
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33377303
25Nitrogen metabolism_Homo sapiens_hsa009101.32982324
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30796780
27Colorectal cancer_Homo sapiens_hsa052101.30597014
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30018779
29Endometrial cancer_Homo sapiens_hsa052131.29535447
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27190987
31Linoleic acid metabolism_Homo sapiens_hsa005911.24769039
32Homologous recombination_Homo sapiens_hsa034401.23405478
33RNA transport_Homo sapiens_hsa030131.22284899
34Long-term potentiation_Homo sapiens_hsa047201.19659458
35Olfactory transduction_Homo sapiens_hsa047401.19583626
36RNA polymerase_Homo sapiens_hsa030201.15608296
37Basal cell carcinoma_Homo sapiens_hsa052171.14326932
38Adherens junction_Homo sapiens_hsa045201.13878862
39DNA replication_Homo sapiens_hsa030301.13276726
40Wnt signaling pathway_Homo sapiens_hsa043101.12343916
41Spliceosome_Homo sapiens_hsa030401.11633513
42Non-small cell lung cancer_Homo sapiens_hsa052231.10946540
43Selenocompound metabolism_Homo sapiens_hsa004501.10808509
44mTOR signaling pathway_Homo sapiens_hsa041501.09074082
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06085531
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06072807
47Glutamatergic synapse_Homo sapiens_hsa047241.04837383
48Taste transduction_Homo sapiens_hsa047421.04813694
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04537634
50Ether lipid metabolism_Homo sapiens_hsa005651.02902934
51Choline metabolism in cancer_Homo sapiens_hsa052311.02644706
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02616661
53Tryptophan metabolism_Homo sapiens_hsa003801.01904928
54Base excision repair_Homo sapiens_hsa034101.01825572
55p53 signaling pathway_Homo sapiens_hsa041151.01595015
56Circadian rhythm_Homo sapiens_hsa047100.98818247
57ErbB signaling pathway_Homo sapiens_hsa040120.98790829
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98218675
59Cocaine addiction_Homo sapiens_hsa050300.97312028
60Dorso-ventral axis formation_Homo sapiens_hsa043200.96860254
61Basal transcription factors_Homo sapiens_hsa030220.95534042
62Glioma_Homo sapiens_hsa052140.93980959
63Prostate cancer_Homo sapiens_hsa052150.93817288
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93108041
65Circadian entrainment_Homo sapiens_hsa047130.91896042
66T cell receptor signaling pathway_Homo sapiens_hsa046600.91862497
67Herpes simplex infection_Homo sapiens_hsa051680.91716228
68Serotonergic synapse_Homo sapiens_hsa047260.91107535
69Long-term depression_Homo sapiens_hsa047300.90736051
70Pathways in cancer_Homo sapiens_hsa052000.90071247
71Hippo signaling pathway_Homo sapiens_hsa043900.89879599
72Chronic myeloid leukemia_Homo sapiens_hsa052200.89873975
73Pancreatic cancer_Homo sapiens_hsa052120.87968957
74Primary immunodeficiency_Homo sapiens_hsa053400.87909251
75Lysine degradation_Homo sapiens_hsa003100.87801737
76Axon guidance_Homo sapiens_hsa043600.87151393
77Thyroid cancer_Homo sapiens_hsa052160.86892045
78HTLV-I infection_Homo sapiens_hsa051660.82940845
79Inositol phosphate metabolism_Homo sapiens_hsa005620.82861249
80Acute myeloid leukemia_Homo sapiens_hsa052210.81929104
81TGF-beta signaling pathway_Homo sapiens_hsa043500.81609981
82Hedgehog signaling pathway_Homo sapiens_hsa043400.81599253
83Salivary secretion_Homo sapiens_hsa049700.81275309
84Caffeine metabolism_Homo sapiens_hsa002320.80667837
85Nucleotide excision repair_Homo sapiens_hsa034200.80663407
86Oocyte meiosis_Homo sapiens_hsa041140.79909251
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79824974
88GnRH signaling pathway_Homo sapiens_hsa049120.79702928
89FoxO signaling pathway_Homo sapiens_hsa040680.78922299
90Small cell lung cancer_Homo sapiens_hsa052220.78165147
91Rap1 signaling pathway_Homo sapiens_hsa040150.77854610
92beta-Alanine metabolism_Homo sapiens_hsa004100.77456100
93Prolactin signaling pathway_Homo sapiens_hsa049170.76938893
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76925354
95B cell receptor signaling pathway_Homo sapiens_hsa046620.76652356
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76344230
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.76214497
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.76027122
99cAMP signaling pathway_Homo sapiens_hsa040240.74627452
100Morphine addiction_Homo sapiens_hsa050320.73831165
101Melanoma_Homo sapiens_hsa052180.73757032
102MAPK signaling pathway_Homo sapiens_hsa040100.73725947
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73444703
104Cardiac muscle contraction_Homo sapiens_hsa042600.73311235
105Viral carcinogenesis_Homo sapiens_hsa052030.72787399
106Oxytocin signaling pathway_Homo sapiens_hsa049210.72759414
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72721344
108Type II diabetes mellitus_Homo sapiens_hsa049300.72660109
109Peroxisome_Homo sapiens_hsa041460.72399960
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.71177143
111Amphetamine addiction_Homo sapiens_hsa050310.70740227
112Alcoholism_Homo sapiens_hsa050340.70255523
113Ras signaling pathway_Homo sapiens_hsa040140.68986733
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68651475
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68517534
116Regulation of autophagy_Homo sapiens_hsa041400.68191359
117Dopaminergic synapse_Homo sapiens_hsa047280.67944206
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67795082
119Ovarian steroidogenesis_Homo sapiens_hsa049130.67580784
120Proteoglycans in cancer_Homo sapiens_hsa052050.67511059
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67242861
122Hepatitis B_Homo sapiens_hsa051610.66890999
123Melanogenesis_Homo sapiens_hsa049160.66814891
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.66636685
125Pancreatic secretion_Homo sapiens_hsa049720.64733495
126Oxidative phosphorylation_Homo sapiens_hsa001900.64677607
127Renin secretion_Homo sapiens_hsa049240.63701527
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63622053
129Cholinergic synapse_Homo sapiens_hsa047250.62916980
130Estrogen signaling pathway_Homo sapiens_hsa049150.62684882
131Phototransduction_Homo sapiens_hsa047440.62248707
132ABC transporters_Homo sapiens_hsa020100.61378648
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61233209
134Calcium signaling pathway_Homo sapiens_hsa040200.61162265
135Retinol metabolism_Homo sapiens_hsa008300.60908529
136Notch signaling pathway_Homo sapiens_hsa043300.60818466
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59991812
138Glycerolipid metabolism_Homo sapiens_hsa005610.59536752
139GABAergic synapse_Homo sapiens_hsa047270.59316002
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59239773
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56355580
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.55523524
143Gastric acid secretion_Homo sapiens_hsa049710.54495514
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52466481
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.52433720
146Fatty acid metabolism_Homo sapiens_hsa012120.51582329
147Chemical carcinogenesis_Homo sapiens_hsa052040.49934114
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49178043
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46415801
150Purine metabolism_Homo sapiens_hsa002300.44592793
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.44514313
152Parkinsons disease_Homo sapiens_hsa050120.44197453
153Tight junction_Homo sapiens_hsa045300.43564907
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42849327

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