ATXN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81396408
2vocalization behavior (GO:0071625)4.35258245
3presynaptic membrane assembly (GO:0097105)4.29937914
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.14521137
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.14215350
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13671353
7protein localization to synapse (GO:0035418)4.09767514
8synaptic vesicle exocytosis (GO:0016079)4.00951164
9neuronal action potential propagation (GO:0019227)3.86624306
10neurotransmitter-gated ion channel clustering (GO:0072578)3.81066415
11ionotropic glutamate receptor signaling pathway (GO:0035235)3.75687530
12neuron cell-cell adhesion (GO:0007158)3.74597542
13postsynaptic membrane organization (GO:0001941)3.73247360
14regulation of glutamate receptor signaling pathway (GO:1900449)3.73089006
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.71050493
16presynaptic membrane organization (GO:0097090)3.70916643
17regulation of synaptic vesicle exocytosis (GO:2000300)3.69765140
18glutamate receptor signaling pathway (GO:0007215)3.62316023
19glutamate secretion (GO:0014047)3.61353884
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44972130
21retinal cone cell development (GO:0046549)3.41737397
22synaptic transmission, glutamatergic (GO:0035249)3.40817103
23neuron-neuron synaptic transmission (GO:0007270)3.36941632
24regulation of synaptic vesicle transport (GO:1902803)3.36281321
25nerve growth factor signaling pathway (GO:0038180)3.34297319
26positive regulation of membrane potential (GO:0045838)3.33493661
27synaptic vesicle maturation (GO:0016188)3.31690994
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30363299
29* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29675811
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.26937975
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26064000
32response to histamine (GO:0034776)3.25386569
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25366185
34locomotory exploration behavior (GO:0035641)3.23250326
35startle response (GO:0001964)3.21364016
36* regulation of postsynaptic membrane potential (GO:0060078)3.16981100
37positive regulation of neurotransmitter secretion (GO:0001956)3.14486704
38cellular response to ethanol (GO:0071361)3.10698423
39positive regulation of neurotransmitter transport (GO:0051590)3.10463799
40regulation of rhodopsin mediated signaling pathway (GO:0022400)3.09354254
41regulation of voltage-gated calcium channel activity (GO:1901385)3.06028246
42long-term synaptic potentiation (GO:0060291)3.03728847
43positive regulation of gamma-delta T cell activation (GO:0046645)3.03329324
44rhodopsin mediated signaling pathway (GO:0016056)3.00699234
45regulation of synapse structural plasticity (GO:0051823)2.99565035
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97098498
47negative regulation of dendrite morphogenesis (GO:0050774)2.96468121
48regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96248388
49regulation of synaptic transmission, glutamatergic (GO:0051966)2.93297792
50regulation of neurotransmitter secretion (GO:0046928)2.89550774
51long-term memory (GO:0007616)2.89333221
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89113955
53regulation of neuronal synaptic plasticity (GO:0048168)2.88755456
54negative regulation of cell killing (GO:0031342)2.88286048
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88286048
56neurotransmitter secretion (GO:0007269)2.87575919
57response to interleukin-15 (GO:0070672)2.78140424
58detection of molecule of bacterial origin (GO:0032490)2.76982989
59cAMP catabolic process (GO:0006198)2.75127261
60regulation of B cell receptor signaling pathway (GO:0050855)2.74319372
61cerebellar Purkinje cell differentiation (GO:0021702)2.73088899
62negative regulation of dendrite development (GO:2000171)2.70587642
63detection of calcium ion (GO:0005513)2.70030533
64behavioral response to cocaine (GO:0048148)2.70029208
65exploration behavior (GO:0035640)2.67564010
66regulation of vesicle fusion (GO:0031338)2.66683020
67behavioral defense response (GO:0002209)2.66515274
68behavioral fear response (GO:0001662)2.66515274
69regulation of synaptic plasticity (GO:0048167)2.65784626
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65489711
71striatum development (GO:0021756)2.65047072
72regulation of neurotransmitter transport (GO:0051588)2.63566437
73cellular response to interleukin-15 (GO:0071350)2.61892324
74membrane hyperpolarization (GO:0060081)2.60961900
75* membrane depolarization (GO:0051899)2.60953855
76cellular extravasation (GO:0045123)2.60346073
77regulation of cell communication by electrical coupling (GO:0010649)2.59304396
78detection of light stimulus involved in sensory perception (GO:0050962)2.58538070
79detection of light stimulus involved in visual perception (GO:0050908)2.58538070
80regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57984077
81eye photoreceptor cell development (GO:0042462)2.57865482
82photoreceptor cell development (GO:0042461)2.56472593
83negative regulation of interleukin-17 production (GO:0032700)2.56366036
84positive regulation of cardiac muscle cell differentiation (GO:2000727)2.55644810
85righting reflex (GO:0060013)2.54757378
86activated T cell proliferation (GO:0050798)2.54505448
87fear response (GO:0042596)2.54424827
88gamma-aminobutyric acid transport (GO:0015812)2.52599765
89innervation (GO:0060384)2.51891071
90female mating behavior (GO:0060180)2.51764768
91negative regulation of interleukin-12 production (GO:0032695)2.51472428
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51435817
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.51259258
94regulation of female receptivity (GO:0045924)2.51189290
95synaptic vesicle endocytosis (GO:0048488)2.50023141
96regulation of gamma-delta T cell activation (GO:0046643)2.49878099
97germinal center formation (GO:0002467)2.48745917
98defense response to protozoan (GO:0042832)2.48292757
99membrane depolarization during action potential (GO:0086010)2.47261301
100positive regulation of synaptic transmission, GABAergic (GO:0032230)2.47224785
101macrophage activation involved in immune response (GO:0002281)2.47119318
102regulation of dendritic spine development (GO:0060998)2.46910748
103neurotransmitter transport (GO:0006836)2.46783771
104* learning (GO:0007612)2.46590747
105positive regulation of synaptic transmission (GO:0050806)2.46371922
106membrane assembly (GO:0071709)2.44614294
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.44296092
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43126185
109Rap protein signal transduction (GO:0032486)2.42778620
110positive regulation of muscle hypertrophy (GO:0014742)2.42020497
111positive regulation of cardiac muscle hypertrophy (GO:0010613)2.42020497
112regulation of synaptic transmission, GABAergic (GO:0032228)2.42014731
113cyclic nucleotide catabolic process (GO:0009214)2.40507056
114synapse assembly (GO:0007416)2.40435741
115negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.37570914
116negative regulation of T-helper cell differentiation (GO:0045623)2.37570914
117behavioral response to ethanol (GO:0048149)2.37254652
118regulation of dendritic spine morphogenesis (GO:0061001)2.35728515
119synaptic transmission (GO:0007268)2.34960379
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.34069938
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.31856540
122photoreceptor cell maintenance (GO:0045494)2.31721624
123long term synaptic depression (GO:0060292)2.31240025
124regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.31050494
125cellular response to epinephrine stimulus (GO:0071872)2.26775731
126regulation of gamma-delta T cell differentiation (GO:0045586)2.23942273
127response to nerve growth factor (GO:1990089)2.23839336
128cellular response to nerve growth factor stimulus (GO:1990090)2.23839336
129response to protozoan (GO:0001562)2.23821017
130macroautophagy (GO:0016236)2.23612125
131negative regulation of T cell mediated immunity (GO:0002710)2.23572493
132phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.22439284
133positive regulation of cellular amide metabolic process (GO:0034250)2.21486875
134regulation of clathrin-mediated endocytosis (GO:2000369)2.16421211
135positive regulation of natural killer cell mediated immunity (GO:0002717)2.13067960
136L-amino acid import (GO:0043092)2.11639664
137regulation of interleukin-12 biosynthetic process (GO:0045075)2.11366812
138regulation of lymphocyte chemotaxis (GO:1901623)2.11245683
139regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.10999317
140regulation of natural killer cell mediated immunity (GO:0002715)2.10999317
141positive regulation of fibroblast migration (GO:0010763)2.10169270
142positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.07753182
143modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.07724957
144positive regulation by organism of defense response of other organism involved in symbiotic interact2.07724957
145modulation by symbiont of host immune response (GO:0052553)2.07724957
146positive regulation by symbiont of host defense response (GO:0052509)2.07724957
147modulation by symbiont of host defense response (GO:0052031)2.07724957
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.07724957
149T-helper cell differentiation (GO:0042093)2.05622707
150CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.05622707
151interkinetic nuclear migration (GO:0022027)2.04704618
152interleukin-6-mediated signaling pathway (GO:0070102)2.04438466
153detection of external biotic stimulus (GO:0098581)2.04350150
154macrophage activation (GO:0042116)2.04188514
155regulation of T-helper 2 cell differentiation (GO:0045628)2.03937918
156positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.03189825
157import into cell (GO:0098657)2.02811735
158positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.02301796
159positive regulation of Rap GTPase activity (GO:0032854)2.00615405
160negative T cell selection (GO:0043383)2.00031911
161antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.00001948
162regulation of ARF protein signal transduction (GO:0032012)1.98279419
163regulation of necroptotic process (GO:0060544)1.98047808
164negative regulation of lymphocyte mediated immunity (GO:0002707)1.97903446
165necroptotic process (GO:0070266)1.96750986
166microglial cell activation (GO:0001774)1.96668572
167positive T cell selection (GO:0043368)1.96627495
168response to epinephrine (GO:0071871)1.95745063
169CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)1.95731352
170sarcoplasmic reticulum calcium ion transport (GO:0070296)1.95345072
171interferon-gamma-mediated signaling pathway (GO:0060333)1.95270700
172negative thymic T cell selection (GO:0045060)1.94297811
173negative regulation of neurotransmitter secretion (GO:0046929)1.93156895
174relaxation of cardiac muscle (GO:0055119)1.92761839
175interferon-gamma production (GO:0032609)1.92166850
176regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)1.91115463
177detection of other organism (GO:0098543)1.91021366
178leukocyte aggregation (GO:0070486)1.90912902
179negative regulation of adaptive immune response based on somatic recombination of immune receptors b1.90740047
180positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.90251779
181regulation of macrophage cytokine production (GO:0010935)1.89476313
182negative regulation of adaptive immune response (GO:0002820)1.89108638
183antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.88511146
184positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.87107117
185regulation of alkaline phosphatase activity (GO:0010692)1.86928099
186lipopolysaccharide-mediated signaling pathway (GO:0031663)1.85669852
187B cell receptor signaling pathway (GO:0050853)1.85483894
188regulation of interleukin-17 production (GO:0032660)1.85365631
189regulation of antigen receptor-mediated signaling pathway (GO:0050854)1.85339141
190regulation of relaxation of muscle (GO:1901077)1.84966193
191lipid translocation (GO:0034204)1.84755488
192phospholipid translocation (GO:0045332)1.84755488
193response to peptidoglycan (GO:0032494)1.84718150
194positive regulation of natural killer cell activation (GO:0032816)1.84345150
195myeloid dendritic cell differentiation (GO:0043011)1.83400008
196regulation of cardiac muscle hypertrophy (GO:0010611)1.83370080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48402120
2GBX2_23144817_ChIP-Seq_PC3_Human3.95699935
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58255287
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57797725
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54011791
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.48166527
7* SMAD_19615063_ChIP-ChIP_OVARY_Human2.26872479
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26418766
9AR_21572438_ChIP-Seq_LNCaP_Human2.25924434
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24578253
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17136068
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17136068
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14228971
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12958919
15TAF15_26573619_Chip-Seq_HEK293_Human2.08732721
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07864253
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.06654813
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.03078071
19RUNX_20019798_ChIP-Seq_JUKART_Human2.01543293
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99930073
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.98086419
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96078459
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95842649
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94650624
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.87173571
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.85444970
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84984799
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80536753
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79889566
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79168647
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77872536
32P300_19829295_ChIP-Seq_ESCs_Human1.76391539
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.76159058
34* DROSHA_22980978_ChIP-Seq_HELA_Human1.74595049
35* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72657915
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.70757783
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69172371
38VDR_24787735_ChIP-Seq_THP-1_Human1.68444832
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.66140581
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.65120027
41REST_21632747_ChIP-Seq_MESCs_Mouse1.63339469
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62348350
43* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59113611
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59031236
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56473674
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.55300218
47* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54031766
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.53226585
49* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52779125
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.44538046
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.42959525
52AR_25329375_ChIP-Seq_VCAP_Human1.41587728
53* RARB_27405468_Chip-Seq_BRAIN_Mouse1.40384892
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40223746
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39980685
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.37864918
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37702937
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37702937
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36038107
60STAT3_23295773_ChIP-Seq_U87_Human1.35545596
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35348748
62* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34923026
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34146025
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33954803
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33098893
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32713843
67* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32674588
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31572426
69IGF1R_20145208_ChIP-Seq_DFB_Human1.31357631
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30678844
71* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30143740
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29982570
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29850527
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.28605165
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27948413
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.27747001
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26675397
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24835643
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24493928
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.23945913
81TCF4_23295773_ChIP-Seq_U87_Human1.23291700
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23012359
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22622856
84TP53_18474530_ChIP-ChIP_U2OS_Human1.22319036
85ER_23166858_ChIP-Seq_MCF-7_Human1.22039922
86* BCAT_22108803_ChIP-Seq_LS180_Human1.21312395
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20930271
88* PRDM14_20953172_ChIP-Seq_ESCs_Human1.20438190
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20425226
90* ESR2_21235772_ChIP-Seq_MCF-7_Human1.20310444
91CJUN_26792858_Chip-Seq_BT549_Human1.20145744
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19769118
93* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19024889
94* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18216316
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.18137939
96TP53_16413492_ChIP-PET_HCT116_Human1.17545647
97VDR_22108803_ChIP-Seq_LS180_Human1.16999392
98* AHR_22903824_ChIP-Seq_MCF-7_Human1.16677256
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.16596764
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16512812
101* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16397441
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16352489
103REST_18959480_ChIP-ChIP_MESCs_Mouse1.16183712
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15783597
105* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14985077
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14731471
107FUS_26573619_Chip-Seq_HEK293_Human1.14130374
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13311741
109* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12827611
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12441994
111P53_22387025_ChIP-Seq_ESCs_Mouse1.12160892
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.10480685
113* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10045527
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.09886783
115* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09425838
116* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08721753
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07972231
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.07940662
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06388508
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05998628
121RNF2_27304074_Chip-Seq_NSC_Mouse1.04925683
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04355725
123* GATA1_22025678_ChIP-Seq_K562_Human1.04118012
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.03285450
125* AR_19668381_ChIP-Seq_PC3_Human1.03095354
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02865795
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02725514
128SCL_19346495_ChIP-Seq_HPC-7_Human1.02112885
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01301713
130* KDM2B_26808549_Chip-Seq_REH_Human1.01087128
131RXR_22108803_ChIP-Seq_LS180_Human1.00879484
132SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00766607
133* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98684277
134* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98025202
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.97863979
136* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97663256
137SOX2_18555785_Chip-Seq_ESCs_Mouse0.97348868
138* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96309286
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95887513
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91372958
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91361481
142* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90320786
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89918761
144* TP63_23658742_ChIP-Seq_EP156T_Human0.89135007
145* SPI1_23127762_ChIP-Seq_K562_Human0.88375458
146* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84529031
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.83207660
148* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81549465
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.81216308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.67153168
2MP0003880_abnormal_central_pattern4.66389466
3* MP0003635_abnormal_synaptic_transmissio3.34667302
4MP0004270_analgesia3.07129100
5MP0009745_abnormal_behavioral_response3.06915531
6MP0003303_peritoneal_inflammation2.95550229
7MP0005551_abnormal_eye_electrophysiolog2.87129987
8MP0002822_catalepsy2.77772500
9MP0009046_muscle_twitch2.71826030
10* MP0002063_abnormal_learning/memory/cond2.69082304
11MP0001188_hyperpigmentation2.67104338
12MP0001968_abnormal_touch/_nociception2.65511232
13MP0002064_seizures2.62359459
14MP0003300_gastrointestinal_ulcer2.47651966
15MP0001486_abnormal_startle_reflex2.44125995
16* MP0002572_abnormal_emotion/affect_behav2.40159729
17MP0002272_abnormal_nervous_system2.24940437
18MP0001501_abnormal_sleep_pattern2.20870201
19MP0002734_abnormal_mechanical_nocicepti2.20767448
20MP0009780_abnormal_chondrocyte_physiolo2.20497205
21MP0005646_abnormal_pituitary_gland2.12347852
22MP0001790_abnormal_immune_system2.11959876
23MP0005387_immune_system_phenotype2.11959876
24MP0001984_abnormal_olfaction2.10920238
25MP0005671_abnormal_response_to2.04304844
26MP0001958_emphysema1.99394050
27MP0003172_abnormal_lysosome_physiology1.98682791
28MP0001835_abnormal_antigen_presentation1.97744334
29MP0002735_abnormal_chemical_nociception1.97367019
30MP0006082_CNS_inflammation1.94566239
31MP0003436_decreased_susceptibility_to1.92264621
32MP0003879_abnormal_hair_cell1.88611962
33MP0000685_abnormal_immune_system1.86201373
34MP0003690_abnormal_glial_cell1.84512592
35MP0003091_abnormal_cell_migration1.83238297
36MP0008569_lethality_at_weaning1.79984468
37* MP0002067_abnormal_sensory_capabilities1.79006255
38MP0005423_abnormal_somatic_nervous1.78977622
39MP0005000_abnormal_immune_tolerance1.78930200
40MP0005409_darkened_coat_color1.78504878
41MP0002736_abnormal_nociception_after1.74558308
42MP0002876_abnormal_thyroid_physiology1.70576757
43MP0002419_abnormal_innate_immunity1.68716642
44MP0001800_abnormal_humoral_immune1.68653476
45MP0002638_abnormal_pupillary_reflex1.65588902
46MP0002148_abnormal_hypersensitivity_rea1.64859966
47MP0001970_abnormal_pain_threshold1.58349478
48MP0001502_abnormal_circadian_rhythm1.56188598
49MP0003763_abnormal_thymus_physiology1.53441374
50MP0003828_pulmonary_edema1.52080922
51MP0009785_altered_susceptibility_to1.50155614
52MP0002998_abnormal_bone_remodeling1.49932429
53MP0002557_abnormal_social/conspecific_i1.48127261
54MP0002723_abnormal_immune_serum1.45481410
55MP0010386_abnormal_urinary_bladder1.44982210
56MP0006276_abnormal_autonomic_nervous1.44528157
57MP0000920_abnormal_myelination1.43284709
58MP0005025_abnormal_response_to1.42930751
59MP0000604_amyloidosis1.41294317
60MP0004883_abnormal_blood_vessel1.39745267
61MP0002452_abnormal_antigen_presenting1.39662506
62MP0004510_myositis1.39421783
63MP0004924_abnormal_behavior1.37575768
64MP0005386_behavior/neurological_phenoty1.37575768
65MP0002909_abnormal_adrenal_gland1.32967940
66MP0002733_abnormal_thermal_nociception1.32805150
67MP0002405_respiratory_system_inflammati1.32282652
68MP0001986_abnormal_taste_sensitivity1.31691880
69MP0004036_abnormal_muscle_relaxation1.31649861
70MP0001440_abnormal_grooming_behavior1.31514344
71MP0001533_abnormal_skeleton_physiology1.31488163
72MP0002184_abnormal_innervation1.30648347
73MP0005164_abnormal_response_to1.28954626
74MP0005253_abnormal_eye_physiology1.28564262
75MP0003191_abnormal_cellular_cholesterol1.26390319
76MP0002332_abnormal_exercise_endurance1.26074935
77MP0002420_abnormal_adaptive_immunity1.25711745
78MP0004145_abnormal_muscle_electrophysio1.24786448
79MP0005166_decreased_susceptibility_to1.24391036
80MP0001819_abnormal_immune_cell1.21543035
81MP0004130_abnormal_muscle_cell1.21127216
82MP0003279_aneurysm1.20970462
83MP0002166_altered_tumor_susceptibility1.17790836
84MP0004484_altered_response_of1.17620439
85MP0000751_myopathy1.16821561
86MP0004947_skin_inflammation1.13780454
87MP0005167_abnormal_blood-brain_barrier1.13427802
88MP0003950_abnormal_plasma_membrane1.12963833
89MP0003329_amyloid_beta_deposits1.12091196
90MP0008438_abnormal_cutaneous_collagen1.11793586
91MP0002009_preneoplasia1.11594254
92* MP0002882_abnormal_neuron_morphology1.10193010
93MP0002090_abnormal_vision1.09628364
94MP0003045_fibrosis1.08893790
95MP0002168_other_aberrant_phenotype1.08879513
96MP0000778_abnormal_nervous_system1.07591174
97MP0000015_abnormal_ear_pigmentation1.05359840
98MP0003656_abnormal_erythrocyte_physiolo1.05200266
99MP0001845_abnormal_inflammatory_respons1.05151978
100MP0003633_abnormal_nervous_system1.04545033
101MP0001851_eye_inflammation1.03943508
102MP0001873_stomach_inflammation1.03425278
103MP0003011_delayed_dark_adaptation1.02345243
104MP0000465_gastrointestinal_hemorrhage1.01857052
105MP0009840_abnormal_foam_cell1.01804802
106MP0004085_abnormal_heartbeat1.01077230
107MP0010155_abnormal_intestine_physiology1.01071017
108* MP0002229_neurodegeneration1.00432425
109MP0001177_atelectasis1.00081640
110MP0006072_abnormal_retinal_apoptosis1.00026283
111MP0002837_dystrophic_cardiac_calcinosis0.99975611
112MP0004811_abnormal_neuron_physiology0.99516083
113MP0003183_abnormal_peptide_metabolism0.97819524
114MP0003136_yellow_coat_color0.96072395
115MP0004142_abnormal_muscle_tone0.95451588
116MP0000371_diluted_coat_color0.94813910
117MP0005645_abnormal_hypothalamus_physiol0.93489063
118MP0005171_absent_coat_pigmentation0.93169062
119* MP0002066_abnormal_motor_capabilities/c0.93027945
120MP0001905_abnormal_dopamine_level0.92889003
121MP0002877_abnormal_melanocyte_morpholog0.91795183
122MP0000249_abnormal_blood_vessel0.91423294
123MP0004215_abnormal_myocardial_fiber0.90612368
124MP0003646_muscle_fatigue0.90287807
125MP0006292_abnormal_olfactory_placode0.90154968
126MP0004084_abnormal_cardiac_muscle0.89870771
127MP0003787_abnormal_imprinting0.89120271
128MP0003866_abnormal_defecation0.88344271
129MP0000767_abnormal_smooth_muscle0.88296890
130MP0008874_decreased_physiological_sensi0.86569172
131MP0001963_abnormal_hearing_physiology0.86053281
132MP0005275_abnormal_skin_tensile0.85524009
133MP0000716_abnormal_immune_system0.85154682
134MP0004381_abnormal_hair_follicle0.84776007
135MP0005084_abnormal_gallbladder_morpholo0.83608799
136MP0005195_abnormal_posterior_eye0.82810105
137MP0004742_abnormal_vestibular_system0.82734122
138MP0002138_abnormal_hepatobiliary_system0.82442003
139MP0002752_abnormal_somatic_nervous0.82068693
140MP0005595_abnormal_vascular_smooth0.81856959
141MP0008004_abnormal_stomach_pH0.81686198
142MP0002933_joint_inflammation0.81279207
143MP0000569_abnormal_digit_pigmentation0.79557272
144MP0005535_abnormal_body_temperature0.78699891
145MP0005058_abnormal_lysosome_morphology0.77117759
146MP0000343_altered_response_to0.76754361
147MP0002006_tumorigenesis0.76130506
148MP0001348_abnormal_lacrimal_gland0.75819894
149MP0002133_abnormal_respiratory_system0.75679832
150MP0005388_respiratory_system_phenotype0.75679832
151MP0006054_spinal_hemorrhage0.73992147
152MP0005464_abnormal_platelet_physiology0.72522883
153MP0000955_abnormal_spinal_cord0.71841211
154MP0003632_abnormal_nervous_system0.71253012
155MP0003634_abnormal_glial_cell0.71034511
156MP0005310_abnormal_salivary_gland0.69477077
157MP0005620_abnormal_muscle_contractility0.68721637
158MP0000013_abnormal_adipose_tissue0.68397125
159MP0003631_nervous_system_phenotype0.68130057
160MP0001324_abnormal_eye_pigmentation0.65002738
161MP0002069_abnormal_eating/drinking_beha0.63691468
162MP0000631_abnormal_neuroendocrine_gland0.63632468
163MP0009379_abnormal_foot_pigmentation0.62921901
164MP0000230_abnormal_systemic_arterial0.62895607
165MP0001664_abnormal_digestion0.61971917
166MP0003075_altered_response_to0.60693095
167MP0001765_abnormal_ion_homeostasis0.60508864
168MP0005174_abnormal_tail_pigmentation0.59779975
169MP0000026_abnormal_inner_ear0.59272046
170MP0005379_endocrine/exocrine_gland_phen0.56169864
171MP0003724_increased_susceptibility_to0.55349150
172MP0002972_abnormal_cardiac_muscle0.52724793

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.81810789
2Febrile seizures (HP:0002373)5.83240219
3Congenital stationary night blindness (HP:0007642)5.33480256
4Epileptic encephalopathy (HP:0200134)4.87619206
5Focal seizures (HP:0007359)4.46965601
6Atonic seizures (HP:0010819)4.44137703
7Hyperventilation (HP:0002883)4.02017946
8Myokymia (HP:0002411)3.88655687
9Broad-based gait (HP:0002136)3.59871770
10Dyschromatopsia (HP:0007641)3.55932391
11Bony spicule pigmentary retinopathy (HP:0007737)3.55491318
12Abnormal rod and cone electroretinograms (HP:0008323)3.54121497
13Absence seizures (HP:0002121)3.47975519
14Central scotoma (HP:0000603)3.45827514
15Abnormality of macular pigmentation (HP:0008002)3.43295893
16* Gaze-evoked nystagmus (HP:0000640)3.27814707
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.23367739
18Dialeptic seizures (HP:0011146)3.16652435
19Decreased central vision (HP:0007663)3.05167413
20Attenuation of retinal blood vessels (HP:0007843)2.98999139
21Spondylolisthesis (HP:0003302)2.98533444
22Visual hallucinations (HP:0002367)2.98002522
23* Progressive cerebellar ataxia (HP:0002073)2.96488406
24T lymphocytopenia (HP:0005403)2.95088940
25Eczematoid dermatitis (HP:0000976)2.91285993
26Generalized tonic-clonic seizures (HP:0002069)2.89374349
27Abnormality of T cell number (HP:0011839)2.82555069
28Action tremor (HP:0002345)2.70701903
29Recurrent bacterial skin infections (HP:0005406)2.69417514
30Pigmentary retinal degeneration (HP:0001146)2.66468817
31Orchitis (HP:0100796)2.61279585
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.61144706
33Abnormality of glycolipid metabolism (HP:0010969)2.61144706
34Abnormality of liposaccharide metabolism (HP:0010968)2.61144706
35Blue irides (HP:0000635)2.58082995
36Gait imbalance (HP:0002141)2.57601079
37Medial flaring of the eyebrow (HP:0010747)2.57523244
38Generalized hypopigmentation of hair (HP:0011358)2.56682071
39Absent speech (HP:0001344)2.51372249
40Nonprogressive disorder (HP:0003680)2.48924925
41Abnormality of macrophages (HP:0004311)2.48811381
42Neurofibrillary tangles (HP:0002185)2.47312264
43Scotoma (HP:0000575)2.46076392
44Congenital primary aphakia (HP:0007707)2.45900589
45Fair hair (HP:0002286)2.44088779
46Prolonged QT interval (HP:0001657)2.42556580
47Pulmonary infiltrates (HP:0002113)2.38912364
48Excessive salivation (HP:0003781)2.38266504
49Drooling (HP:0002307)2.38266504
50Aortic dissection (HP:0002647)2.37127369
51Anxiety (HP:0000739)2.36741751
52Gastrointestinal infarctions (HP:0005244)2.36207701
53Severe visual impairment (HP:0001141)2.32330821
54Myositis (HP:0100614)2.31685629
55Nephrogenic diabetes insipidus (HP:0009806)2.31298094
56Protruding tongue (HP:0010808)2.28895686
57Submucous cleft hard palate (HP:0000176)2.28892941
58Inability to walk (HP:0002540)2.28867881
59Spontaneous hematomas (HP:0007420)2.28084568
60Increased corneal curvature (HP:0100692)2.27822621
61Keratoconus (HP:0000563)2.27822621
62Atrial fibrillation (HP:0005110)2.27645346
63Chronic mucocutaneous candidiasis (HP:0002728)2.26884542
64Recurrent cutaneous fungal infections (HP:0011370)2.26884542
65Stomatitis (HP:0010280)2.26148209
66Papilledema (HP:0001085)2.22949567
67Mediastinal lymphadenopathy (HP:0100721)2.22181011
68Recurrent abscess formation (HP:0002722)2.21771668
69Aortic aneurysm (HP:0004942)2.20507204
70Abnormality of incisor morphology (HP:0011063)2.19354699
71Hyporeflexia of lower limbs (HP:0002600)2.18959088
72Choroideremia (HP:0001139)2.18433117
73Hemoptysis (HP:0002105)2.17736162
74Asymmetric septal hypertrophy (HP:0001670)2.17568986
75Progressive inability to walk (HP:0002505)2.17551852
76Recurrent fungal infections (HP:0002841)2.17138530
77Photophobia (HP:0000613)2.17071371
78Bradycardia (HP:0001662)2.16847325
79Cerebral inclusion bodies (HP:0100314)2.16271459
80Subacute progressive viral hepatitis (HP:0006572)2.15349871
81Vitreoretinal degeneration (HP:0000655)2.14959119
82Depression (HP:0000716)2.14817345
83Primary atrial arrhythmia (HP:0001692)2.14455155
84Increased CSF protein (HP:0002922)2.13106346
85Congenital sensorineural hearing impairment (HP:0008527)2.13099236
86Abnormal ciliary motility (HP:0012262)2.12988008
87Chorioretinal atrophy (HP:0000533)2.12613924
88Dysostosis multiplex (HP:0000943)2.11868205
89Bundle branch block (HP:0011710)2.11035334
90Arterial tortuosity (HP:0005116)2.10660124
91Peritonitis (HP:0002586)2.09817491
92Abnormal hair whorl (HP:0010721)2.09455209
93Syncope (HP:0001279)2.09030548
94Hemiplegia (HP:0002301)2.08317385
95Muscle hypertrophy of the lower extremities (HP:0008968)2.06633090
96Recurrent skin infections (HP:0001581)2.04818394
97Diplopia (HP:0000651)2.04789267
98Hematochezia (HP:0002573)2.03958511
99Absent frontal sinuses (HP:0002688)2.03154451
100Difficulty running (HP:0009046)2.01948882
101Abnormal eating behavior (HP:0100738)2.01523191
102Mucopolysacchariduria (HP:0008155)2.01486827
103Urinary glycosaminoglycan excretion (HP:0003541)2.01486827
104Stereotypic behavior (HP:0000733)2.00976041
105Widely spaced teeth (HP:0000687)2.00627577
106Gingivitis (HP:0000230)1.99904700
107Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99886421
108Abnormality of polysaccharide metabolism (HP:0011012)1.99886421
109Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99886421
110Vascular tortuosity (HP:0004948)1.99799710
111Amblyopia (HP:0000646)1.98788247
112Hypothermia (HP:0002045)1.98513876
113Poor eye contact (HP:0000817)1.97884876
114Recurrent gram-negative bacterial infections (HP:0005420)1.95493484
115Abnormal EKG (HP:0003115)1.95365106
116Impaired vibration sensation in the lower limbs (HP:0002166)1.93945386
117Supraventricular tachycardia (HP:0004755)1.93193907
118Postural instability (HP:0002172)1.93108872
119Retrobulbar optic neuritis (HP:0100654)1.92831452
120Optic neuritis (HP:0100653)1.92831452
121Poor coordination (HP:0002370)1.92483455
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.92333983
123Lower limb amyotrophy (HP:0007210)1.91561656
124* Truncal ataxia (HP:0002078)1.89745839
125Gingival bleeding (HP:0000225)1.89568297
126Retinitis pigmentosa (HP:0000510)1.89399733
127Autoimmune hemolytic anemia (HP:0001890)1.88718852
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.88113041
129Absent/shortened dynein arms (HP:0200106)1.88113041
130Chronic diarrhea (HP:0002028)1.87036375
131Chronic hepatic failure (HP:0100626)1.85601507
132Aplasia/Hypoplasia of the lens (HP:0008063)1.85522466
133Distal lower limb amyotrophy (HP:0008944)1.84344065
134Keratoconjunctivitis sicca (HP:0001097)1.83899724
135Supraventricular arrhythmia (HP:0005115)1.83838008
136True hermaphroditism (HP:0010459)1.82679880
137Impaired social interactions (HP:0000735)1.82094215
138Abnormal social behavior (HP:0012433)1.82094215
139Abnormality of salivation (HP:0100755)1.81700361
140Vasculitis (HP:0002633)1.81322167
141Overgrowth (HP:0001548)1.80367058
142Abnormal respiratory motile cilium physiology (HP:0012261)1.80204469
143Pulmonary embolism (HP:0002204)1.78111083
144Genital tract atresia (HP:0001827)1.77948238
145Type 1 muscle fiber predominance (HP:0003803)1.76582371
146Epileptiform EEG discharges (HP:0011182)1.76040569
147Deeply set eye (HP:0000490)1.75029044
148* Dysdiadochokinesis (HP:0002075)1.74176109
149Pancreatic fibrosis (HP:0100732)1.74114397
150* Dysmetria (HP:0001310)1.73471559
151Vaginal atresia (HP:0000148)1.72999814
152Supranuclear gaze palsy (HP:0000605)1.72835131
153Chest pain (HP:0100749)1.72196657
154Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71995163
155Disinhibition (HP:0000734)1.71470133
156Abnormality of the nasal septum (HP:0000419)1.70876970
157Keratoconjunctivitis (HP:0001096)1.70711563
158Decreased circulating renin level (HP:0003351)1.70603973
159Increased cerebral lipofuscin (HP:0011813)1.70075303
160Agitation (HP:0000713)1.69804597
161Narrow palate (HP:0000189)1.69349780
162Spinal canal stenosis (HP:0003416)1.69004498
163Frequent falls (HP:0002359)1.68546155
164Thickened calvaria (HP:0002684)1.68418478
165Fetal akinesia sequence (HP:0001989)1.68209681
166Arterial thrombosis (HP:0004420)1.68156712
167Abnormality of the periventricular white matter (HP:0002518)1.67762400
168Obstructive sleep apnea (HP:0002870)1.67151899
169Muscle fiber splitting (HP:0003555)1.66687068
170Retinal dysplasia (HP:0007973)1.66655129
171Abnormality of binocular vision (HP:0011514)1.66652973
172Systemic lupus erythematosus (HP:0002725)1.66192993
173Autoimmune thrombocytopenia (HP:0001973)1.65125439
174Vacuolated lymphocytes (HP:0001922)1.65060283
175Cerebral aneurysm (HP:0004944)1.64194741
176Subaortic stenosis (HP:0001682)1.61942650
177Abnormality of the left ventricular outflow tract (HP:0011103)1.61942650
178Neuronal loss in central nervous system (HP:0002529)1.61588262
179Abnormality of secondary sexual hair (HP:0009888)1.59953362
180Abnormality of the axillary hair (HP:0100134)1.59953362
181Neoplasm of the tracheobronchial system (HP:0100552)1.59576246
182Hypoplasia of the iris (HP:0007676)1.57657052
183Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57362898
184Mutism (HP:0002300)1.57306683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.70456200
2EPHA43.50641454
3MAP2K73.09038559
4NTRK33.00887561
5TRPM72.65359838
6INSRR2.47725390
7MAP3K122.46064302
8TNIK2.40978422
9MAP3K42.37094273
10MUSK2.29003596
11RIPK42.17088213
12SGK21.97013793
13AKT31.88243020
14DAPK21.87270120
15PRPF4B1.83508418
16BLK1.82416736
17CAMKK21.74814911
18TXK1.67978114
19BMPR21.66122107
20TYK21.50689916
21FES1.48410321
22PLK21.47702344
23MAP2K31.47476721
24MAP2K41.46592000
25SGK2231.36200045
26SGK4941.36200045
27NEK91.33159005
28SGK31.30893154
29PIK3CG1.30629998
30NLK1.29406145
31RIPK11.27843271
32MINK11.27497289
33CSK1.27210271
34NTRK21.26041404
35MAP3K31.23787960
36TNK21.23656182
37MAPK131.22306787
38STK381.19391984
39CAMK11.19082107
40TTN1.17143225
41SIK31.14849766
42DAPK11.13580915
43CAMKK11.12439665
44PINK11.12168109
45CDK191.11336399
46MATK1.08401782
47TGFBR21.07343012
48CAMK2A1.04575696
49PAK31.03411175
50PRKCH1.02208752
51PRKD21.00137641
52WNK10.97126644
53CDK50.96305516
54PDGFRB0.95784619
55MAP4K10.94990336
56FRK0.94419486
57CDC42BPA0.94274449
58SIK20.92768599
59ZAP700.91776421
60CDK30.91511481
61MAP3K130.90129293
62SGK10.89734926
63EPHB10.89646921
64MKNK20.89123990
65GRK10.88860583
66HCK0.88656777
67JAK20.88568708
68MAP3K90.87657055
69ITK0.86625173
70PRKCE0.86230258
71NEK60.86178043
72JAK30.85692133
73GRK50.85039249
74KIT0.84490387
75DDR20.78614760
76PRKCG0.78287150
77FGFR40.77641755
78MARK10.77051321
79PTK2B0.76869557
80PAK60.76819880
81SYK0.76784531
82EPHA30.75380564
83IRAK40.75189892
84MAP3K70.74764427
85MYLK0.74024593
86MAPK120.73254679
87PIK3CA0.72326659
88DMPK0.72271207
89PDPK10.71631335
90CAMK2B0.70930116
91IKBKB0.70339945
92NUAK10.69787473
93TYRO30.69194938
94RET0.68459300
95MAPK70.68290429
96MELK0.68240559
97JAK10.68118557
98NME10.67550851
99MARK20.67372242
100NTRK10.66575146
101CHUK0.66258875
102PHKG20.64612939
103PHKG10.64612939
104MAP3K140.63996909
105LCK0.62048684
106KSR10.61692925
107CAMK40.61057128
108STK110.60865149
109KSR20.60663340
110CAMK2D0.60642994
111DYRK1A0.60632351
112MAP3K10.59036856
113FGFR30.58004794
114TAOK10.57251522
115HIPK20.54490263
116PDGFRA0.54257386
117MARK30.52850691
118ZAK0.52565572
119CCNB10.51964170
120GRK70.51825578
121FER0.51813238
122TBK10.51813021
123ACVR1B0.50436669
124PRKD30.49729908
125PRKCQ0.48919675
126OBSCN0.48886022
127PRKAA20.48573231
128FYN0.48056343
129PRKG10.47263498
130CAMK1G0.46752682
131OXSR10.46384787
132TEC0.46209823
133ARAF0.43320252
134PDK10.43037114
135MAP3K20.42743977
136IKBKE0.42517518
137STK240.42072088
138MAP3K60.39131712
139* PRKACA0.38629353
140TAOK30.38603674
141MAP3K50.38503332
142ADRBK10.35147557
143IRAK10.35004120

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.79865107
2Nicotine addiction_Homo sapiens_hsa050333.35343836
3Olfactory transduction_Homo sapiens_hsa047402.64106595
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49542029
5Synaptic vesicle cycle_Homo sapiens_hsa047212.47693806
6Morphine addiction_Homo sapiens_hsa050322.44404809
7Circadian entrainment_Homo sapiens_hsa047132.40081528
8GABAergic synapse_Homo sapiens_hsa047272.29603242
9Glutamatergic synapse_Homo sapiens_hsa047242.25422867
10Long-term potentiation_Homo sapiens_hsa047202.14253819
11Amphetamine addiction_Homo sapiens_hsa050312.02879694
12Salivary secretion_Homo sapiens_hsa049701.90717169
13Insulin secretion_Homo sapiens_hsa049111.82757923
14Taste transduction_Homo sapiens_hsa047421.79886844
15Renin secretion_Homo sapiens_hsa049241.73444871
16Dopaminergic synapse_Homo sapiens_hsa047281.72861784
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68686790
18Cholinergic synapse_Homo sapiens_hsa047251.67115757
19Serotonergic synapse_Homo sapiens_hsa047261.64670083
20Calcium signaling pathway_Homo sapiens_hsa040201.58395076
21Oxytocin signaling pathway_Homo sapiens_hsa049211.51975452
22Long-term depression_Homo sapiens_hsa047301.45854287
23Leishmaniasis_Homo sapiens_hsa051401.42722456
24Gastric acid secretion_Homo sapiens_hsa049711.41751793
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37626179
26Collecting duct acid secretion_Homo sapiens_hsa049661.35906964
27Staphylococcus aureus infection_Homo sapiens_hsa051501.35741061
28B cell receptor signaling pathway_Homo sapiens_hsa046621.35683232
29Cocaine addiction_Homo sapiens_hsa050301.34130383
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32688747
31cAMP signaling pathway_Homo sapiens_hsa040241.32165103
32Circadian rhythm_Homo sapiens_hsa047101.30963614
33TNF signaling pathway_Homo sapiens_hsa046681.25599473
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22453352
35Malaria_Homo sapiens_hsa051441.20757181
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16639155
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16344573
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15458301
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14463713
40GnRH signaling pathway_Homo sapiens_hsa049121.13993301
41Measles_Homo sapiens_hsa051621.13920749
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11099304
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10656371
44Toxoplasmosis_Homo sapiens_hsa051451.10465356
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08428171
46Dilated cardiomyopathy_Homo sapiens_hsa054141.07779466
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.06607778
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06170101
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04297999
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03916865
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00388313
52Renal cell carcinoma_Homo sapiens_hsa052110.99839728
53Type II diabetes mellitus_Homo sapiens_hsa049300.98666560
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.94873908
55Amoebiasis_Homo sapiens_hsa051460.93398680
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92952484
57VEGF signaling pathway_Homo sapiens_hsa043700.91544847
58Hematopoietic cell lineage_Homo sapiens_hsa046400.91014954
59Pertussis_Homo sapiens_hsa051330.90311093
60Acute myeloid leukemia_Homo sapiens_hsa052210.89412206
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88365556
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86905556
63Influenza A_Homo sapiens_hsa051640.85774094
64mTOR signaling pathway_Homo sapiens_hsa041500.85473873
65Insulin resistance_Homo sapiens_hsa049310.84101566
66Melanogenesis_Homo sapiens_hsa049160.83348591
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83145408
68Type I diabetes mellitus_Homo sapiens_hsa049400.82550902
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81677448
70Non-small cell lung cancer_Homo sapiens_hsa052230.81655821
71FoxO signaling pathway_Homo sapiens_hsa040680.81523544
72Rheumatoid arthritis_Homo sapiens_hsa053230.81053124
73ErbB signaling pathway_Homo sapiens_hsa040120.80310311
74Gap junction_Homo sapiens_hsa045400.80228523
75Endometrial cancer_Homo sapiens_hsa052130.78169983
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77463332
77African trypanosomiasis_Homo sapiens_hsa051430.77197382
78Legionellosis_Homo sapiens_hsa051340.75511116
79MAPK signaling pathway_Homo sapiens_hsa040100.75181739
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75132922
81Pancreatic secretion_Homo sapiens_hsa049720.74947368
82Vibrio cholerae infection_Homo sapiens_hsa051100.74624689
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74553864
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74333750
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.72876745
86Lysosome_Homo sapiens_hsa041420.72820508
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72720452
88Complement and coagulation cascades_Homo sapiens_hsa046100.72238095
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70838939
90Hepatitis C_Homo sapiens_hsa051600.70489897
91Cardiac muscle contraction_Homo sapiens_hsa042600.70230052
92Focal adhesion_Homo sapiens_hsa045100.69384471
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.69303198
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68848289
95Hepatitis B_Homo sapiens_hsa051610.68477835
96Glioma_Homo sapiens_hsa052140.68252773
97Allograft rejection_Homo sapiens_hsa053300.67559585
98Autoimmune thyroid disease_Homo sapiens_hsa053200.67417888
99Axon guidance_Homo sapiens_hsa043600.67129884
100Ovarian steroidogenesis_Homo sapiens_hsa049130.66801377
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66703445
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66343246
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65010591
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64196137
105Proteoglycans in cancer_Homo sapiens_hsa052050.63487324
106Viral myocarditis_Homo sapiens_hsa054160.63297922
107Other glycan degradation_Homo sapiens_hsa005110.63166888
108Pancreatic cancer_Homo sapiens_hsa052120.63034550
109Chronic myeloid leukemia_Homo sapiens_hsa052200.62484293
110Inositol phosphate metabolism_Homo sapiens_hsa005620.62168155
111Ras signaling pathway_Homo sapiens_hsa040140.61962230
112Estrogen signaling pathway_Homo sapiens_hsa049150.59787905
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.58093655
114Chemokine signaling pathway_Homo sapiens_hsa040620.56814266
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55799259
116Thyroid hormone synthesis_Homo sapiens_hsa049180.55268418
117Rap1 signaling pathway_Homo sapiens_hsa040150.54560870
118Choline metabolism in cancer_Homo sapiens_hsa052310.53834089
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51646299
120T cell receptor signaling pathway_Homo sapiens_hsa046600.51079882
121Dorso-ventral axis formation_Homo sapiens_hsa043200.48708553
122Sphingolipid metabolism_Homo sapiens_hsa006000.46645744
123Asthma_Homo sapiens_hsa053100.46575464
124Glucagon signaling pathway_Homo sapiens_hsa049220.46519544
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45216325
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44719094
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44572483
128Graft-versus-host disease_Homo sapiens_hsa053320.44359551
129Wnt signaling pathway_Homo sapiens_hsa043100.43472093
130Platelet activation_Homo sapiens_hsa046110.42377836
131Prolactin signaling pathway_Homo sapiens_hsa049170.41064606
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.40431041
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.38789238
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.38140895
135Tuberculosis_Homo sapiens_hsa051520.33070224
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32746449
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32156405
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31879062
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29939857
140Osteoclast differentiation_Homo sapiens_hsa043800.29307406
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.29229993

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