ATXN10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.05544302
2synaptic vesicle maturation (GO:0016188)4.53368144
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52160558
4regulation of synaptic vesicle exocytosis (GO:2000300)4.42499091
5positive regulation of synapse maturation (GO:0090129)4.39393579
6glutamate secretion (GO:0014047)4.38175941
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37744534
8peptidyl-arginine omega-N-methylation (GO:0035247)4.24168415
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.21593144
10negative regulation of microtubule polymerization (GO:0031115)4.11997186
11protein localization to synapse (GO:0035418)4.02132754
12peptidyl-arginine methylation (GO:0018216)3.87186445
13peptidyl-arginine N-methylation (GO:0035246)3.87186445
14histone arginine methylation (GO:0034969)3.86616681
15regulation of synaptic vesicle transport (GO:1902803)3.83312469
16layer formation in cerebral cortex (GO:0021819)3.75836296
17neurotransmitter secretion (GO:0007269)3.72032104
18neuron cell-cell adhesion (GO:0007158)3.69722931
19locomotory exploration behavior (GO:0035641)3.67967539
20response to pheromone (GO:0019236)3.65755499
21vocalization behavior (GO:0071625)3.64350921
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.61942172
23nucleobase catabolic process (GO:0046113)3.52954331
24cullin deneddylation (GO:0010388)3.51238454
25regulation of synapse structural plasticity (GO:0051823)3.50956206
26exploration behavior (GO:0035640)3.49704949
27positive regulation of mitochondrial fission (GO:0090141)3.48406782
28regulation of glutamate receptor signaling pathway (GO:1900449)3.43989797
29establishment of mitochondrion localization (GO:0051654)3.40652483
30presynaptic membrane assembly (GO:0097105)3.36033024
31regulation of synapse maturation (GO:0090128)3.28520851
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26780247
33neuron recognition (GO:0008038)3.23187147
34innervation (GO:0060384)3.21152228
35postsynaptic membrane organization (GO:0001941)3.19618910
36DNA damage response, detection of DNA damage (GO:0042769)3.18072076
37cell migration in hindbrain (GO:0021535)3.14174866
38axonal fasciculation (GO:0007413)3.12819360
39presynaptic membrane organization (GO:0097090)3.10624179
40intraciliary transport (GO:0042073)3.10444708
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07657412
42protein deneddylation (GO:0000338)3.05854567
43mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.05052912
44establishment of integrated proviral latency (GO:0075713)3.03537530
45proline transport (GO:0015824)3.02519605
46L-serine metabolic process (GO:0006563)3.00917921
47regulation of neuronal synaptic plasticity (GO:0048168)2.97795709
48regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96251581
49DNA double-strand break processing (GO:0000729)2.92660016
50protein polyglutamylation (GO:0018095)2.90144425
51positive regulation of dendritic spine morphogenesis (GO:0061003)2.88986705
52cerebellar Purkinje cell layer development (GO:0021680)2.87924931
53positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87659702
54neuronal action potential propagation (GO:0019227)2.85155260
55nonmotile primary cilium assembly (GO:0035058)2.85126548
56neurotransmitter transport (GO:0006836)2.82024889
57synaptic vesicle endocytosis (GO:0048488)2.81919551
58synaptic transmission, glutamatergic (GO:0035249)2.81717024
59cell communication by electrical coupling (GO:0010644)2.81459108
60regulation of vesicle fusion (GO:0031338)2.80251544
61neuron-neuron synaptic transmission (GO:0007270)2.79547725
62proteasome assembly (GO:0043248)2.79136443
63positive regulation of synapse assembly (GO:0051965)2.76427935
64histone H2A acetylation (GO:0043968)2.76237031
65ATP hydrolysis coupled proton transport (GO:0015991)2.74856764
66energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.74856764
67establishment of synaptic vesicle localization (GO:0097480)2.73253552
68synaptic vesicle transport (GO:0048489)2.73253552
69ribonucleoprotein complex disassembly (GO:0032988)2.71690861
70pyrimidine nucleobase catabolic process (GO:0006208)2.71510608
71organelle transport along microtubule (GO:0072384)2.68727648
72activation of protein kinase A activity (GO:0034199)2.67397103
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66435254
74neurotransmitter-gated ion channel clustering (GO:0072578)2.64604574
75COPI coating of Golgi vesicle (GO:0048205)2.63652719
76Golgi transport vesicle coating (GO:0048200)2.63652719
77ionotropic glutamate receptor signaling pathway (GO:0035235)2.62748699
78axon extension (GO:0048675)2.60469191
79transferrin transport (GO:0033572)2.59599312
80regulation of synapse organization (GO:0050807)2.59480315
81behavioral defense response (GO:0002209)2.58457936
82behavioral fear response (GO:0001662)2.58457936
83establishment of vesicle localization (GO:0051650)2.58183959
84glutamate receptor signaling pathway (GO:0007215)2.57009502
85vesicle transport along microtubule (GO:0047496)2.56861877
86DNA ligation (GO:0006266)2.56393810
87gamma-aminobutyric acid signaling pathway (GO:0007214)2.55381701
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55374339
89long-term synaptic potentiation (GO:0060291)2.54101421
90cholesterol biosynthetic process (GO:0006695)2.53545362
91regulation of neurotransmitter levels (GO:0001505)2.53121665
92synapse assembly (GO:0007416)2.52528448
93adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.51584638
94regulation of neurotransmitter secretion (GO:0046928)2.49927759
95cerebellum development (GO:0021549)2.49494211
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49408216
97axon cargo transport (GO:0008088)2.49045853
98chromatin remodeling at centromere (GO:0031055)2.48337488
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47551648
100neuromuscular synaptic transmission (GO:0007274)2.46668474
101organelle disassembly (GO:1903008)2.45621400
102dendritic spine morphogenesis (GO:0060997)2.45555442
103regulation of synaptic plasticity (GO:0048167)2.45499691
104chaperone-mediated protein transport (GO:0072321)2.45409303
105cochlea development (GO:0090102)2.44987862
106negative regulation of DNA recombination (GO:0045910)2.44944418
107iron-sulfur cluster assembly (GO:0016226)2.44185093
108metallo-sulfur cluster assembly (GO:0031163)2.44185093
109long-term memory (GO:0007616)2.42688360
110protein neddylation (GO:0045116)2.42405337
111establishment of nucleus localization (GO:0040023)2.41924869
112gamma-aminobutyric acid transport (GO:0015812)2.41421814
113regulation of mitochondrial translation (GO:0070129)2.41221102
114fear response (GO:0042596)2.40444022
115dendrite morphogenesis (GO:0048813)2.40003871
116regulation of synapse assembly (GO:0051963)2.39518586
117CENP-A containing nucleosome assembly (GO:0034080)2.39211504
118dendrite development (GO:0016358)2.38937075
119neuromuscular process controlling posture (GO:0050884)2.38245504
120establishment of viral latency (GO:0019043)2.38090357
121regulation of cAMP-dependent protein kinase activity (GO:2000479)2.37905276
122ferric iron transport (GO:0015682)2.37886923
123trivalent inorganic cation transport (GO:0072512)2.37886923
124cytoskeleton-dependent intracellular transport (GO:0030705)2.36742801
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.36521291
126epithelial cilium movement (GO:0003351)2.36279442
127protein localization to cilium (GO:0061512)2.35954318
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.35488432
129calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.35485866
130transmission of nerve impulse (GO:0019226)2.35203980
131hippocampus development (GO:0021766)2.34679542
132cellular potassium ion homeostasis (GO:0030007)2.34510107
133response to auditory stimulus (GO:0010996)2.34076888
134establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.34058076
135mitochondrion transport along microtubule (GO:0047497)2.34058076
136peptidyl-cysteine modification (GO:0018198)2.34051430
137sterol biosynthetic process (GO:0016126)2.32184343
138cilium morphogenesis (GO:0060271)2.31590997
139aldehyde catabolic process (GO:0046185)2.29342539
140retinal ganglion cell axon guidance (GO:0031290)2.26688403
141mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.26083265
142water-soluble vitamin biosynthetic process (GO:0042364)2.25590396
143de novo protein folding (GO:0006458)2.22782625
144DNA integration (GO:0015074)2.21262266
145olfactory bulb development (GO:0021772)2.21160274
146regulation of coenzyme metabolic process (GO:0051196)2.19900939
147regulation of cofactor metabolic process (GO:0051193)2.19900939
148de novo posttranslational protein folding (GO:0051084)2.19727582
149establishment of melanosome localization (GO:0032401)2.17215339
150regulation of mitochondrial fission (GO:0090140)2.14682028
151tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.13189902
152RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.13189902
153cilium assembly (GO:0042384)2.10865318
154short-term memory (GO:0007614)2.10761740
155neurofilament cytoskeleton organization (GO:0060052)2.10722272
156anterograde axon cargo transport (GO:0008089)2.10139318
157mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.09532048
158cilium organization (GO:0044782)2.09098990
159microtubule-based transport (GO:0010970)2.08892070
160resolution of meiotic recombination intermediates (GO:0000712)2.08503634
161branched-chain amino acid catabolic process (GO:0009083)2.07608442
162melanosome transport (GO:0032402)2.06420111
163mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.06262021
164positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.06262021
165regulation of cilium movement (GO:0003352)2.05480400
166histone exchange (GO:0043486)2.03830978
167tRNA aminoacylation for protein translation (GO:0006418)2.03811540
168protein K11-linked ubiquitination (GO:0070979)2.02836045
169DNA replication-independent nucleosome assembly (GO:0006336)2.02751275
170DNA replication-independent nucleosome organization (GO:0034724)2.02751275
171establishment of pigment granule localization (GO:0051905)2.02207965
172protein complex biogenesis (GO:0070271)2.01383736
173oxidative phosphorylation (GO:0006119)2.00522670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.85431325
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12643101
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.06755298
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00461685
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.97937995
6GBX2_23144817_ChIP-Seq_PC3_Human2.80101964
7REST_21632747_ChIP-Seq_MESCs_Mouse2.51579034
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.40298527
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37214687
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32420622
11* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29348792
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27050685
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23659099
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22906943
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.22069020
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19229573
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18676573
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12683530
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12570120
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11069196
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09713840
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05086613
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.01702256
24* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01371247
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99045653
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99045653
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.95130650
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93750817
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92654787
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88310277
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86847751
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.85930634
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81058675
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80230371
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75656283
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.75214462
37ZNF274_21170338_ChIP-Seq_K562_Hela1.74135989
38EWS_26573619_Chip-Seq_HEK293_Human1.73452864
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73377103
40ELK1_19687146_ChIP-ChIP_HELA_Human1.73253690
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.70926516
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.65589857
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62105819
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.62034810
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57837906
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56751802
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56639247
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53095114
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52864207
50CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.52594022
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44226173
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42971755
53MYC_18940864_ChIP-ChIP_HL60_Human1.41705435
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41177368
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40387808
56* GABP_19822575_ChIP-Seq_HepG2_Human1.40080880
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39689135
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39289902
59VDR_23849224_ChIP-Seq_CD4+_Human1.36981297
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35247593
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34829247
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32001899
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31332874
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31266909
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29602925
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28277071
67TTF2_22483619_ChIP-Seq_HELA_Human1.27365854
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27156723
69DCP1A_22483619_ChIP-Seq_HELA_Human1.26533495
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25766364
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.25719704
72DROSHA_22980978_ChIP-Seq_HELA_Human1.24753395
73* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24280987
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23987772
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23713758
76RNF2_27304074_Chip-Seq_NSC_Mouse1.23709706
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21403162
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.21277626
79* MYC_18555785_ChIP-Seq_MESCs_Mouse1.20872122
80* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20571320
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20076129
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19411336
83IGF1R_20145208_ChIP-Seq_DFB_Human1.19354093
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.18495838
85FUS_26573619_Chip-Seq_HEK293_Human1.17975137
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17722960
87IRF1_19129219_ChIP-ChIP_H3396_Human1.17487152
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17286329
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17026825
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16515726
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15118186
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15118185
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14550466
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13656265
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.12824454
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12503613
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11868987
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.11620739
99REST_19997604_ChIP-ChIP_NEURONS_Mouse1.11115048
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10654767
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.10514547
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09503510
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09425318
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09392822
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09214338
106* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09186094
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08565031
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.08532490
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08115785
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07511264
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06368823
112SOX9_26525672_Chip-Seq_HEART_Mouse1.06129072
113FOXP3_21729870_ChIP-Seq_TREG_Human1.05401644
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.03948216
115* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03881436
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03773943
117TP53_20018659_ChIP-ChIP_R1E_Mouse1.03680789
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03041421
119MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03002125
120* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02926991
121TAF15_26573619_Chip-Seq_HEK293_Human1.02086699
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01548154
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01215525
124* SMAD4_21799915_ChIP-Seq_A2780_Human1.01174900
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00628088
126* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99268774
127XRN2_22483619_ChIP-Seq_HELA_Human0.98832327
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98248850
129POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98058509
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97769100
131* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97594564
132P300_19829295_ChIP-Seq_ESCs_Human0.97437662
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.96907746
134AR_21572438_ChIP-Seq_LNCaP_Human0.96588786
135YY1_21170310_ChIP-Seq_MESCs_Mouse0.96563333
136CBP_20019798_ChIP-Seq_JUKART_Human0.95663298
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95663298
138* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95595975
139JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94683984
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93778370
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93354907
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92489153
143* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92406259
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92112915
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91755636
146PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91622455
147SMAD3_21741376_ChIP-Seq_EPCs_Human0.91530051
148TP53_22573176_ChIP-Seq_HFKS_Human0.90557159
149JUN_21703547_ChIP-Seq_K562_Human0.90523635
150EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89325128
151SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89099230
152PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88367040
153SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88131040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.25483539
2MP0003880_abnormal_central_pattern4.09169355
3MP0003122_maternal_imprinting3.62997111
4MP0003635_abnormal_synaptic_transmissio3.07924270
5MP0002063_abnormal_learning/memory/cond2.60071347
6MP0006276_abnormal_autonomic_nervous2.53734905
7MP0004270_analgesia2.50656697
8MP0001968_abnormal_touch/_nociception2.45299356
9MP0003123_paternal_imprinting2.44014676
10MP0005423_abnormal_somatic_nervous2.36523986
11MP0009780_abnormal_chondrocyte_physiolo2.28583869
12MP0009745_abnormal_behavioral_response2.21361204
13MP0003121_genomic_imprinting2.18266438
14MP0002064_seizures2.15874612
15MP0002734_abnormal_mechanical_nocicepti2.09083354
16MP0002572_abnormal_emotion/affect_behav2.04556103
17MP0004858_abnormal_nervous_system2.00032739
18MP0002736_abnormal_nociception_after1.99580932
19MP0002184_abnormal_innervation1.95403160
20MP0009046_muscle_twitch1.93568254
21MP0000778_abnormal_nervous_system1.90546168
22MP0002735_abnormal_chemical_nociception1.90053913
23MP0002733_abnormal_thermal_nociception1.80904244
24MP0003787_abnormal_imprinting1.79493651
25MP0002909_abnormal_adrenal_gland1.79000033
26MP0003283_abnormal_digestive_organ1.76245901
27MP0002822_catalepsy1.75286380
28MP0002272_abnormal_nervous_system1.70284432
29MP0006292_abnormal_olfactory_placode1.64792334
30MP0004811_abnormal_neuron_physiology1.64267337
31MP0001529_abnormal_vocalization1.60030292
32MP0000955_abnormal_spinal_cord1.58681215
33MP0001970_abnormal_pain_threshold1.55932789
34MP0008058_abnormal_DNA_repair1.54994560
35MP0002938_white_spotting1.54973465
36MP0003937_abnormal_limbs/digits/tail_de1.54838084
37MP0002067_abnormal_sensory_capabilities1.54732864
38MP0002557_abnormal_social/conspecific_i1.53107571
39MP0002653_abnormal_ependyma_morphology1.52604909
40MP0005645_abnormal_hypothalamus_physiol1.47901857
41MP0001440_abnormal_grooming_behavior1.47668503
42MP0004233_abnormal_muscle_weight1.46806217
43MP0010386_abnormal_urinary_bladder1.44208596
44MP0002751_abnormal_autonomic_nervous1.43548872
45MP0001984_abnormal_olfaction1.43256875
46MP0005187_abnormal_penis_morphology1.42831517
47MP0000013_abnormal_adipose_tissue1.42697573
48MP0004133_heterotaxia1.39494584
49MP0003119_abnormal_digestive_system1.38356356
50MP0001293_anophthalmia1.36289962
51MP0002233_abnormal_nose_morphology1.35613362
52MP0001486_abnormal_startle_reflex1.35573145
53MP0004147_increased_porphyrin_level1.34559235
54MP0002638_abnormal_pupillary_reflex1.31373883
55MP0002882_abnormal_neuron_morphology1.30844632
56MP0001188_hyperpigmentation1.27024604
57MP0005646_abnormal_pituitary_gland1.25988791
58MP0003329_amyloid_beta_deposits1.22802884
59MP0006072_abnormal_retinal_apoptosis1.21538662
60MP0002152_abnormal_brain_morphology1.21401854
61MP0004924_abnormal_behavior1.21120467
62MP0005386_behavior/neurological_phenoty1.21120467
63MP0010030_abnormal_orbit_morphology1.21110316
64MP0000566_synostosis1.21009215
65MP0000631_abnormal_neuroendocrine_gland1.18536222
66MP0000537_abnormal_urethra_morphology1.14512453
67MP0005499_abnormal_olfactory_system1.14503875
68MP0005394_taste/olfaction_phenotype1.14503875
69MP0010094_abnormal_chromosome_stability1.12901480
70MP0003136_yellow_coat_color1.12680381
71MP0005623_abnormal_meninges_morphology1.10503990
72MP0008569_lethality_at_weaning1.08384808
73MP0002066_abnormal_motor_capabilities/c1.08294891
74MP0003861_abnormal_nervous_system1.07390539
75MP0000534_abnormal_ureter_morphology1.06813940
76MP0001501_abnormal_sleep_pattern1.06445042
77MP0005084_abnormal_gallbladder_morpholo1.05934613
78MP0001502_abnormal_circadian_rhythm1.00617112
79MP0003942_abnormal_urinary_system0.99268266
80MP0006035_abnormal_mitochondrial_morpho0.98882166
81MP0002837_dystrophic_cardiac_calcinosis0.97033174
82MP0003567_abnormal_fetal_cardiomyocyte0.96838840
83MP0005248_abnormal_Harderian_gland0.95793403
84MP0003890_abnormal_embryonic-extraembry0.95755794
85MP0001299_abnormal_eye_distance/0.95227478
86MP0003755_abnormal_palate_morphology0.93170894
87MP0003879_abnormal_hair_cell0.92196985
88MP0003315_abnormal_perineum_morphology0.91859857
89MP0000026_abnormal_inner_ear0.91447433
90MP0000751_myopathy0.90749595
91MP0002234_abnormal_pharynx_morphology0.90601713
92MP0008789_abnormal_olfactory_epithelium0.89078018
93MP0001485_abnormal_pinna_reflex0.89028235
94MP0004142_abnormal_muscle_tone0.88091184
95MP0002697_abnormal_eye_size0.86799155
96MP0001286_abnormal_eye_development0.86132601
97MP0004215_abnormal_myocardial_fiber0.85487550
98MP0004885_abnormal_endolymph0.85306930
99MP0003385_abnormal_body_wall0.84913115
100MP0000647_abnormal_sebaceous_gland0.84698405
101MP0005391_vision/eye_phenotype0.83691443
102MP0002177_abnormal_outer_ear0.83535367
103MP0000049_abnormal_middle_ear0.82039519
104MP0002282_abnormal_trachea_morphology0.81515021
105MP0001963_abnormal_hearing_physiology0.79275982
106MP0002752_abnormal_somatic_nervous0.79224887
107MP0003693_abnormal_embryo_hatching0.79134808
108MP0005171_absent_coat_pigmentation0.79086459
109MP0001348_abnormal_lacrimal_gland0.78014481
110MP0009697_abnormal_copulation0.77562618
111MP0003183_abnormal_peptide_metabolism0.76009521
112MP0001905_abnormal_dopamine_level0.75214681
113MP0003115_abnormal_respiratory_system0.74915981
114MP0002069_abnormal_eating/drinking_beha0.73257485
115MP0008877_abnormal_DNA_methylation0.71733656
116MP0005551_abnormal_eye_electrophysiolog0.71268957
117MP0001943_abnormal_respiration0.70494116
118MP0008961_abnormal_basal_metabolism0.68986466
119MP0005253_abnormal_eye_physiology0.67576802
120MP0002081_perinatal_lethality0.67087506
121MP0008932_abnormal_embryonic_tissue0.65623107
122MP0002084_abnormal_developmental_patter0.64258112
123MP0002090_abnormal_vision0.63517461
124MP0003634_abnormal_glial_cell0.63372262
125MP0002089_abnormal_postnatal_growth/wei0.62712684
126MP0001986_abnormal_taste_sensitivity0.60498126
127MP0001664_abnormal_digestion0.59575762
128MP0004085_abnormal_heartbeat0.59265107
129MP0001177_atelectasis0.58692467
130MP0004145_abnormal_muscle_electrophysio0.58642862
131MP0002102_abnormal_ear_morphology0.57694720

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.08298519
2Myokymia (HP:0002411)3.97066919
3Visual hallucinations (HP:0002367)3.94669612
4Epileptic encephalopathy (HP:0200134)3.40263389
5Focal seizures (HP:0007359)3.31896780
6Atonic seizures (HP:0010819)3.30342912
7Cortical dysplasia (HP:0002539)3.14299585
8Absence seizures (HP:0002121)3.06949058
9Abnormality of the labia minora (HP:0012880)3.02106072
10Hyperglycinemia (HP:0002154)2.89980705
11Failure to thrive in infancy (HP:0001531)2.86785834
12Limb dystonia (HP:0002451)2.81352031
13Ankle clonus (HP:0011448)2.78483502
14Pheochromocytoma (HP:0002666)2.76139654
15Polyphagia (HP:0002591)2.65883503
16Dialeptic seizures (HP:0011146)2.57279334
17Increased serum pyruvate (HP:0003542)2.52150682
18Amyotrophic lateral sclerosis (HP:0007354)2.50731386
19Neuroendocrine neoplasm (HP:0100634)2.50147869
20Genital tract atresia (HP:0001827)2.49901271
21Febrile seizures (HP:0002373)2.49385011
22Abnormality of the lower motor neuron (HP:0002366)2.46863837
23Lissencephaly (HP:0001339)2.46806825
24Vaginal atresia (HP:0000148)2.46721893
25Abnormality of the corticospinal tract (HP:0002492)2.46130714
26Amblyopia (HP:0000646)2.42977900
27Hypoventilation (HP:0002791)2.42099489
28Generalized tonic-clonic seizures (HP:0002069)2.40758631
29True hermaphroditism (HP:0010459)2.39654409
30Abnormality of glycolysis (HP:0004366)2.39183562
31Pancreatic fibrosis (HP:0100732)2.37796671
32Acute necrotizing encephalopathy (HP:0006965)2.36263796
33Shoulder girdle muscle weakness (HP:0003547)2.35337409
34Megalencephaly (HP:0001355)2.35008780
35Abnormality of midbrain morphology (HP:0002418)2.29660288
36Molar tooth sign on MRI (HP:0002419)2.29660288
37Poor suck (HP:0002033)2.28975664
38Gait imbalance (HP:0002141)2.28780731
39Broad foot (HP:0001769)2.27777751
40Colon cancer (HP:0003003)2.27441078
41Abnormal eating behavior (HP:0100738)2.27114579
42Epileptiform EEG discharges (HP:0011182)2.26894435
43Acute encephalopathy (HP:0006846)2.25554435
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.21963301
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.21963301
46EEG with generalized epileptiform discharges (HP:0011198)2.21686012
47* Depression (HP:0000716)2.19969941
48Nephronophthisis (HP:0000090)2.19225914
49Atrophy/Degeneration involving motor neurons (HP:0007373)2.19030590
50Occipital encephalocele (HP:0002085)2.18524515
51Truncal ataxia (HP:0002078)2.18144462
52Abnormal mitochondria in muscle tissue (HP:0008316)2.17029686
53Agitation (HP:0000713)2.16543781
54Supranuclear gaze palsy (HP:0000605)2.15181968
55Retinal dysplasia (HP:0007973)2.14186060
56Abnormal hair whorl (HP:0010721)2.13765966
57Mutism (HP:0002300)2.13680921
58Impaired pain sensation (HP:0007328)2.11124637
59Abnormality of pain sensation (HP:0010832)2.11124637
60Drooling (HP:0002307)2.10287437
61Excessive salivation (HP:0003781)2.10287437
62Intestinal atresia (HP:0011100)2.10001843
63Split foot (HP:0001839)2.08970624
64Bifid tongue (HP:0010297)2.08111566
65Postaxial hand polydactyly (HP:0001162)2.06005030
66Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06002614
67Hypoplasia of the brainstem (HP:0002365)2.06002614
68Papilledema (HP:0001085)2.05952163
69Hepatocellular necrosis (HP:0001404)2.05843719
70Hypsarrhythmia (HP:0002521)2.05294139
71Hepatic necrosis (HP:0002605)2.05208118
72Neoplasm of the peripheral nervous system (HP:0100007)2.03476366
73Poor eye contact (HP:0000817)2.03030310
74Mitochondrial inheritance (HP:0001427)2.02132317
75Impaired vibration sensation in the lower limbs (HP:0002166)2.02015822
76Increased hepatocellular lipid droplets (HP:0006565)2.00070938
77Abnormality of the musculature of the pelvis (HP:0001469)1.98901637
78Abnormality of the hip-girdle musculature (HP:0001445)1.98901637
79Specific learning disability (HP:0001328)1.97940501
80Decreased testicular size (HP:0008734)1.97654171
81Menstrual irregularities (HP:0000858)1.96999840
82Pointed chin (HP:0000307)1.95901634
83Increased CSF lactate (HP:0002490)1.93944039
84Progressive macrocephaly (HP:0004481)1.93583717
85Postaxial foot polydactyly (HP:0001830)1.92290977
86Pancreatic cysts (HP:0001737)1.90656458
87Anxiety (HP:0000739)1.89596754
88Congenital primary aphakia (HP:0007707)1.88950310
89* Progressive cerebellar ataxia (HP:0002073)1.88605694
90Hemiparesis (HP:0001269)1.87347139
91Abnormality of glycine metabolism (HP:0010895)1.86927324
92Abnormality of serine family amino acid metabolism (HP:0010894)1.86927324
93Poor coordination (HP:0002370)1.84744134
94Hypercortisolism (HP:0001578)1.84485198
95Exercise-induced muscle cramps (HP:0003710)1.81442348
96Preaxial hand polydactyly (HP:0001177)1.80912720
97Lipid accumulation in hepatocytes (HP:0006561)1.80127214
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.79511323
99Labial hypoplasia (HP:0000066)1.79171584
100Short tibia (HP:0005736)1.78967587
101Neuroblastoma (HP:0003006)1.77816673
102Primitive neuroectodermal tumor (HP:0030065)1.77816673
103Neuroblastic tumors (HP:0004376)1.77816673
104Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.77816673
105Renal duplication (HP:0000075)1.77714052
106Generalized hypotonia (HP:0001290)1.76788518
107Impaired smooth pursuit (HP:0007772)1.76427151
108Action tremor (HP:0002345)1.76388145
109Methylmalonic acidemia (HP:0002912)1.75384629
110Narrow forehead (HP:0000341)1.74761178
111Narrow nasal bridge (HP:0000446)1.74716458
112Hepatoblastoma (HP:0002884)1.74575684
113Sclerocornea (HP:0000647)1.74122959
114Nephrogenic diabetes insipidus (HP:0009806)1.72308979
115Spastic tetraplegia (HP:0002510)1.71523051
116Abnormality of the astrocytes (HP:0100707)1.70875285
117Astrocytoma (HP:0009592)1.70875285
118Micropenis (HP:0000054)1.70376575
119Diplopia (HP:0000651)1.69776072
120Abnormality of binocular vision (HP:0011514)1.69776072
121Bradykinesia (HP:0002067)1.68158340
122Optic nerve coloboma (HP:0000588)1.67950850
123Cerebral edema (HP:0002181)1.67891592
124Ependymoma (HP:0002888)1.66370318
125Rimmed vacuoles (HP:0003805)1.65997030
126Postnatal microcephaly (HP:0005484)1.65717062
127Volvulus (HP:0002580)1.65525517
128Pachygyria (HP:0001302)1.64659119
129Medial flaring of the eyebrow (HP:0010747)1.64106849
130Hypoplastic female external genitalia (HP:0012815)1.63707428
131Hyperventilation (HP:0002883)1.63429082
132Hyperthyroidism (HP:0000836)1.63195835
133Abnormality of ocular smooth pursuit (HP:0000617)1.62579266
134Neoplasm of the adrenal gland (HP:0100631)1.62266352
135Testicular neoplasm (HP:0010788)1.62139648
136Delusions (HP:0000746)1.61935416
137Anencephaly (HP:0002323)1.60573051
138Resting tremor (HP:0002322)1.59892784
139Broad-based gait (HP:0002136)1.59795714
140Unsteady gait (HP:0002317)1.59762183
141Abnormality of the renal medulla (HP:0100957)1.59364260
142Anophthalmia (HP:0000528)1.58587900
143Abnormality of the metopic suture (HP:0005556)1.58303715
144Tubulointerstitial nephritis (HP:0001970)1.58173745
145Termporal pattern (HP:0011008)1.57464553
146Insidious onset (HP:0003587)1.57464553
147Insomnia (HP:0100785)1.57342928
148Intellectual disability, profound (HP:0002187)1.57197664
149Abnormal lung lobation (HP:0002101)1.57069793
150Sleep apnea (HP:0010535)1.56949526
151Absent speech (HP:0001344)1.56845135
152Diminished motivation (HP:0000745)1.56511220
153Muscular hypotonia of the trunk (HP:0008936)1.56478064
154Apathy (HP:0000741)1.56174239
155Ankyloglossia (HP:0010296)1.56126150
156Hypoplastic pelvis (HP:0008839)1.56025482
157Medulloblastoma (HP:0002885)1.55920015
158Hyperglycinuria (HP:0003108)1.55855134
159Microvesicular hepatic steatosis (HP:0001414)1.55724996
160Aganglionic megacolon (HP:0002251)1.55568742
161Cerebral hypomyelination (HP:0006808)1.55484352
162Abnormality of serum amino acid levels (HP:0003112)1.54981549
163Renal hypoplasia (HP:0000089)1.54803627
164Impaired social interactions (HP:0000735)1.54792914
165Abnormal social behavior (HP:0012433)1.54792914
166Abnormality of the anterior horn cell (HP:0006802)1.53593354
167Degeneration of anterior horn cells (HP:0002398)1.53593354
168Hypoplasia of the pons (HP:0012110)1.52879344
169Stenosis of the external auditory canal (HP:0000402)1.51985169
170Delayed gross motor development (HP:0002194)1.50814863
171Dandy-Walker malformation (HP:0001305)1.50647493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.80817283
2MINK13.20859369
3MAP3K123.15023769
4NTRK33.12313212
5MAP3K92.86672844
6TRIM282.82040491
7MAP4K22.79197205
8MAP3K42.59028751
9BCKDK2.48827707
10KSR12.47114365
11NEK12.33925247
12SRPK12.28799860
13CASK2.19504315
14SCYL22.03951274
15MAP2K71.96641562
16CSNK1A1L1.95605507
17CSNK1G11.92659379
18BUB11.92270810
19LIMK11.89178033
20PLK21.88844148
21EPHA41.87596110
22SIK31.82082520
23DAPK11.73054509
24CDK191.72367828
25TSSK61.70744308
26ERBB31.67716196
27PINK11.60949216
28NTRK21.57839831
29UHMK11.50656616
30PAK61.50055438
31TESK11.47188787
32LATS21.47148840
33BCR1.42033203
34DAPK21.41885099
35KSR21.39709107
36CDK141.31313444
37CDK181.27782492
38MAP2K41.25045453
39PLK41.23637624
40BRSK11.22234902
41MAPK131.22204510
42MKNK11.20768873
43DYRK21.20472852
44PNCK1.19513018
45PRKD31.18686108
46WNK31.16013110
47PLK31.15949324
48PASK1.15517462
49VRK21.15416704
50CDK151.15293776
51ZAK1.13915011
52BRAF1.13780303
53DYRK31.12192261
54CDK51.11482282
55FER1.09046006
56NTRK11.08475910
57CAMKK11.08339139
58TTK1.07228860
59RPS6KA41.04924804
60CDK11A1.04675348
61CDK81.04117034
62PRKCG1.03976372
63ARAF0.98076660
64CCNB10.97968684
65* PLK10.96448697
66PRPF4B0.95109355
67PAK30.94332651
68BMPR1B0.92621363
69TGFBR10.92538267
70VRK10.92089526
71PHKG10.90308158
72PHKG20.90308158
73CAMKK20.89634550
74STK160.87060912
75DYRK1A0.87003020
76CDC70.84037151
77PDK40.77673372
78PDK30.77673372
79MKNK20.77553624
80AURKA0.76868220
81STK390.76776689
82ACVR1B0.75441421
83MAP2K10.73961448
84TESK20.73750415
85AKT30.68333571
86GRK50.68269788
87CSNK1G20.67250716
88TAF10.66541553
89FGFR10.64613190
90EIF2AK10.64373969
91OXSR10.64197299
92ATR0.59279754
93STK38L0.59211708
94CAMK2A0.58746550
95TAOK20.58713135
96RAF10.58645932
97LMTK20.56676221
98NME10.53703485
99RPS6KA20.52867970
100ROCK20.51820646
101PBK0.50997048
102CSNK1G30.50758441
103ALK0.50381055
104DYRK1B0.49246789
105STK380.49186444
106CSNK1E0.49106494
107AURKB0.47808260
108FLT30.47094835
109MAP3K20.46393922
110CAMK2B0.46334037
111SGK2230.45837315
112SGK4940.45837315
113EPHB20.45784274
114ADRBK10.45648808
115PRKCI0.45149797
116CAMK2D0.45100060
117PAK40.44975816
118WEE10.44621876
119CHEK20.43593829
120NUAK10.42966588
121GRK10.42014551
122CSNK1D0.41539091
123TYRO30.41251904
124ATM0.40861035
125PRKCZ0.40744548
126CSNK1A10.39784065
127CAMK2G0.38985799
128CAMK10.38091441
129ILK0.37656883
130RET0.37451974
131PDK20.35648470
132EIF2AK30.35326688
133TNIK0.35008380
134AKT20.34559667
135CDK30.34201707
136PTK2B0.33962810
137WNK40.33586806
138DAPK30.32881299
139PRKCE0.32628727

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.78596598
2Nicotine addiction_Homo sapiens_hsa050333.23187053
3Protein export_Homo sapiens_hsa030602.70618351
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46267514
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.35345433
6GABAergic synapse_Homo sapiens_hsa047272.29491579
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18256082
8Vibrio cholerae infection_Homo sapiens_hsa051102.13340368
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11556105
10Circadian entrainment_Homo sapiens_hsa047132.10744757
11Steroid biosynthesis_Homo sapiens_hsa001002.09828160
12Long-term potentiation_Homo sapiens_hsa047202.08678318
13Collecting duct acid secretion_Homo sapiens_hsa049662.05042752
14Dopaminergic synapse_Homo sapiens_hsa047282.02513597
15Propanoate metabolism_Homo sapiens_hsa006402.01102452
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00178808
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.94406593
18Amphetamine addiction_Homo sapiens_hsa050311.90395966
19Olfactory transduction_Homo sapiens_hsa047401.88640595
20Morphine addiction_Homo sapiens_hsa050321.88410079
21Insulin secretion_Homo sapiens_hsa049111.78108071
22Fatty acid elongation_Homo sapiens_hsa000621.77887122
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74295757
24Base excision repair_Homo sapiens_hsa034101.70071233
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68361897
26Oocyte meiosis_Homo sapiens_hsa041141.67868815
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66388622
28Glutamatergic synapse_Homo sapiens_hsa047241.62543210
29Pyruvate metabolism_Homo sapiens_hsa006201.55229594
30RNA polymerase_Homo sapiens_hsa030201.55114343
31Gap junction_Homo sapiens_hsa045401.53563110
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51498409
33Biosynthesis of amino acids_Homo sapiens_hsa012301.48077082
34Cholinergic synapse_Homo sapiens_hsa047251.45452132
35Long-term depression_Homo sapiens_hsa047301.43949284
36Vitamin B6 metabolism_Homo sapiens_hsa007501.42468221
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40956620
38Taste transduction_Homo sapiens_hsa047421.36420277
39Butanoate metabolism_Homo sapiens_hsa006501.36283845
40Serotonergic synapse_Homo sapiens_hsa047261.36255820
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35734487
42Cocaine addiction_Homo sapiens_hsa050301.35143907
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34884199
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34300676
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34089241
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32981993
47Carbon metabolism_Homo sapiens_hsa012001.32209693
48Non-homologous end-joining_Homo sapiens_hsa034501.30948827
49Phototransduction_Homo sapiens_hsa047441.28253413
50Basal transcription factors_Homo sapiens_hsa030221.26639782
51Fanconi anemia pathway_Homo sapiens_hsa034601.26420734
52Proteasome_Homo sapiens_hsa030501.24827175
53Oxytocin signaling pathway_Homo sapiens_hsa049211.20798469
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19606819
55Axon guidance_Homo sapiens_hsa043601.18892800
56Salivary secretion_Homo sapiens_hsa049701.18719832
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.14572580
58RNA degradation_Homo sapiens_hsa030181.13942016
59Melanogenesis_Homo sapiens_hsa049161.10743154
60Renin secretion_Homo sapiens_hsa049241.10151740
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09527397
62Folate biosynthesis_Homo sapiens_hsa007901.08592943
63Pyrimidine metabolism_Homo sapiens_hsa002401.08360955
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08090954
65Homologous recombination_Homo sapiens_hsa034401.07663714
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06247697
67Oxidative phosphorylation_Homo sapiens_hsa001901.00945853
68Gastric acid secretion_Homo sapiens_hsa049711.00791640
69Cardiac muscle contraction_Homo sapiens_hsa042601.00542466
70Estrogen signaling pathway_Homo sapiens_hsa049151.00212080
71Fatty acid metabolism_Homo sapiens_hsa012120.98885402
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98248158
73Parkinsons disease_Homo sapiens_hsa050120.96913957
74Glioma_Homo sapiens_hsa052140.96790956
75Colorectal cancer_Homo sapiens_hsa052100.95249464
76GnRH signaling pathway_Homo sapiens_hsa049120.94224689
77Hippo signaling pathway_Homo sapiens_hsa043900.92250457
78Selenocompound metabolism_Homo sapiens_hsa004500.91810461
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90478120
80Purine metabolism_Homo sapiens_hsa002300.89707536
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89412722
82Alcoholism_Homo sapiens_hsa050340.87261098
83Sulfur relay system_Homo sapiens_hsa041220.87252126
84Hedgehog signaling pathway_Homo sapiens_hsa043400.87092009
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86578887
86Calcium signaling pathway_Homo sapiens_hsa040200.86530660
87ErbB signaling pathway_Homo sapiens_hsa040120.86435895
88Peroxisome_Homo sapiens_hsa041460.84271919
89Endometrial cancer_Homo sapiens_hsa052130.83669941
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83173674
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.82496584
92RNA transport_Homo sapiens_hsa030130.80272653
93Arginine and proline metabolism_Homo sapiens_hsa003300.80194427
94One carbon pool by folate_Homo sapiens_hsa006700.79301763
95Huntingtons disease_Homo sapiens_hsa050160.78580971
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78492635
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.77654305
98Spliceosome_Homo sapiens_hsa030400.77258895
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76735230
100N-Glycan biosynthesis_Homo sapiens_hsa005100.76270308
101Wnt signaling pathway_Homo sapiens_hsa043100.75719122
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75385209
103mRNA surveillance pathway_Homo sapiens_hsa030150.72603603
104Mismatch repair_Homo sapiens_hsa034300.72216333
105Cell cycle_Homo sapiens_hsa041100.70881445
106cAMP signaling pathway_Homo sapiens_hsa040240.70498631
107beta-Alanine metabolism_Homo sapiens_hsa004100.68745244
108Regulation of autophagy_Homo sapiens_hsa041400.68663437
109Alzheimers disease_Homo sapiens_hsa050100.68603054
110Metabolic pathways_Homo sapiens_hsa011000.67368068
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64086301
112Type I diabetes mellitus_Homo sapiens_hsa049400.62570316
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62197402
114Glucagon signaling pathway_Homo sapiens_hsa049220.62096096
115Bladder cancer_Homo sapiens_hsa052190.61963710
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60457926
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58091988
118Phagosome_Homo sapiens_hsa041450.58047226
119Basal cell carcinoma_Homo sapiens_hsa052170.57920244
120Thyroid hormone synthesis_Homo sapiens_hsa049180.57004971
121Thyroid cancer_Homo sapiens_hsa052160.56524681
122Renal cell carcinoma_Homo sapiens_hsa052110.55851836
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55764697
124Type II diabetes mellitus_Homo sapiens_hsa049300.55314962
125Glutathione metabolism_Homo sapiens_hsa004800.52692291
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52357820
127Endocytosis_Homo sapiens_hsa041440.51692640
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51632446
129Melanoma_Homo sapiens_hsa052180.51012458
130Nucleotide excision repair_Homo sapiens_hsa034200.51009714
131Ribosome_Homo sapiens_hsa030100.50538628
132Dilated cardiomyopathy_Homo sapiens_hsa054140.49294409
133Rap1 signaling pathway_Homo sapiens_hsa040150.49222989
134mTOR signaling pathway_Homo sapiens_hsa041500.48740714
135Fatty acid degradation_Homo sapiens_hsa000710.47685436
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47666776
137MAPK signaling pathway_Homo sapiens_hsa040100.46264311
138Insulin signaling pathway_Homo sapiens_hsa049100.45443782
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45348778
140Tight junction_Homo sapiens_hsa045300.45217562
141DNA replication_Homo sapiens_hsa030300.45047326
142VEGF signaling pathway_Homo sapiens_hsa043700.44552964
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44318585
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.44181568
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43047574
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.42626873
147Non-small cell lung cancer_Homo sapiens_hsa052230.42234538
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41092838
149Circadian rhythm_Homo sapiens_hsa047100.39511596
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37810445

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