ATXN1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)4.61993052
2regulation of hippo signaling (GO:0035330)4.48980552
3negative regulation of erythrocyte differentiation (GO:0045647)4.24129300
4protein localization to endosome (GO:0036010)4.15384025
5regulation of NFAT protein import into nucleus (GO:0051532)3.94267084
6cell adhesion mediated by integrin (GO:0033627)3.88901630
7embryonic process involved in female pregnancy (GO:0060136)3.85429516
8positive regulation of histone deacetylation (GO:0031065)3.46420060
9regulation of histone H3-K27 methylation (GO:0061085)3.40532987
10hippo signaling (GO:0035329)3.40255049
11growth hormone receptor signaling pathway (GO:0060396)3.38794290
12pre-miRNA processing (GO:0031054)3.36362976
13positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.36347014
14response to muramyl dipeptide (GO:0032495)3.29677658
15stress fiber assembly (GO:0043149)3.17075670
16mannose metabolic process (GO:0006013)3.11493409
17response to peptidoglycan (GO:0032494)3.08507234
183-UTR-mediated mRNA stabilization (GO:0070935)3.08164762
19NLS-bearing protein import into nucleus (GO:0006607)3.07058598
20mitotic sister chromatid cohesion (GO:0007064)3.01848010
21cytoskeletal anchoring at plasma membrane (GO:0007016)2.99610947
22insulin-like growth factor receptor signaling pathway (GO:0048009)2.91450077
23cellular response to growth hormone stimulus (GO:0071378)2.86084642
24corticosteroid receptor signaling pathway (GO:0031958)2.85517929
25glucocorticoid receptor signaling pathway (GO:0042921)2.84341765
26regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.81938938
27nuclear pore complex assembly (GO:0051292)2.80468657
28adherens junction assembly (GO:0034333)2.80416777
29pinocytosis (GO:0006907)2.74881929
30positive regulation of fatty acid beta-oxidation (GO:0032000)2.73759760
31cell migration involved in sprouting angiogenesis (GO:0002042)2.71550789
32positive regulation of gamma-delta T cell activation (GO:0046645)2.69173957
33embryonic retina morphogenesis in camera-type eye (GO:0060059)2.68725997
34apoptotic cell clearance (GO:0043277)2.68645963
35regulation of RNA export from nucleus (GO:0046831)2.63078495
36regulation of fatty acid beta-oxidation (GO:0031998)2.62186193
37trophectodermal cell differentiation (GO:0001829)2.61425888
38negative regulation of fatty acid transport (GO:2000192)2.60944619
39regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.59428083
40monoubiquitinated protein deubiquitination (GO:0035520)2.58524669
41peptidyl-lysine dimethylation (GO:0018027)2.56707432
42positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55740534
43cortical actin cytoskeleton organization (GO:0030866)2.54947459
44positive regulation of Cdc42 GTPase activity (GO:0043089)2.52043134
45histone H3-K4 trimethylation (GO:0080182)2.51721881
46cell-substrate junction assembly (GO:0007044)2.47154953
47regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46865903
48negative regulation of histone methylation (GO:0031061)2.45789841
49positive regulation by symbiont of host defense response (GO:0052509)2.45560266
50modulation by symbiont of host defense response (GO:0052031)2.45560266
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45560266
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45560266
53positive regulation by organism of defense response of other organism involved in symbiotic interact2.45560266
54modulation by symbiont of host immune response (GO:0052553)2.45560266
55regulation of nucleobase-containing compound transport (GO:0032239)2.45515138
56regulation of clathrin-mediated endocytosis (GO:2000369)2.44540215
57low-density lipoprotein particle clearance (GO:0034383)2.44045043
58protein dealkylation (GO:0008214)2.43760134
59protein demethylation (GO:0006482)2.43760134
60histone H3-K36 demethylation (GO:0070544)2.43066508
61vascular endothelial growth factor signaling pathway (GO:0038084)2.42974128
62modulation by symbiont of host cellular process (GO:0044068)2.42970050
63regulation of early endosome to late endosome transport (GO:2000641)2.41606323
64regulation of cholesterol homeostasis (GO:2000188)2.41459182
65coronary vasculature morphogenesis (GO:0060977)2.40798059
66regulation of protein polyubiquitination (GO:1902914)2.39683205
67dosage compensation (GO:0007549)2.38613760
68embryonic camera-type eye morphogenesis (GO:0048596)2.38311695
69positive regulation of extracellular matrix organization (GO:1903055)2.37577946
70labyrinthine layer development (GO:0060711)2.37303186
71cell-substrate adherens junction assembly (GO:0007045)2.37035047
72focal adhesion assembly (GO:0048041)2.37035047
73paraxial mesoderm development (GO:0048339)2.36993438
74hypotonic response (GO:0006971)2.35855081
75negative regulation of toll-like receptor signaling pathway (GO:0034122)2.35104485
76detection of other organism (GO:0098543)2.34744672
77endodermal cell differentiation (GO:0035987)2.34330956
78cellular extravasation (GO:0045123)2.34220181
79platelet-derived growth factor receptor signaling pathway (GO:0048008)2.34176721
80germinal center formation (GO:0002467)2.34118211
81plasma membrane repair (GO:0001778)2.33081005
82positive regulation of p38MAPK cascade (GO:1900745)2.31579536
83macroautophagy (GO:0016236)2.31369742
84regulation of glucose import in response to insulin stimulus (GO:2001273)2.30883624
85positive regulation of cellular response to insulin stimulus (GO:1900078)2.30727537
86negative regulation of cell size (GO:0045792)2.30421200
87regulation of gamma-delta T cell activation (GO:0046643)2.30263183
88response to fluid shear stress (GO:0034405)2.30172593
89regulation of chromatin binding (GO:0035561)2.29917912
90regulation of ARF protein signal transduction (GO:0032012)2.29772472
91positive regulation of keratinocyte differentiation (GO:0045618)2.29240954
92polarized epithelial cell differentiation (GO:0030859)2.28841814
93regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.28520507
94histone lysine demethylation (GO:0070076)2.28410601
95positive regulation of glycogen biosynthetic process (GO:0045725)2.28405666
96peptidyl-threonine modification (GO:0018210)2.27819918
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.27605746
98positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.27438350
99semaphorin-plexin signaling pathway (GO:0071526)2.27435160
100embryonic eye morphogenesis (GO:0048048)2.26807726
101histone H3-K9 demethylation (GO:0033169)2.26727637
102mitotic chromosome condensation (GO:0007076)2.26562566
103epithelial cell differentiation involved in prostate gland development (GO:0060742)2.25734956
104regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.25428880
105mRNA stabilization (GO:0048255)2.25369529
106RNA stabilization (GO:0043489)2.25369529
107heart morphogenesis (GO:0003007)2.25116691
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.24864407
109definitive hemopoiesis (GO:0060216)2.24520699
110histone H3-K4 methylation (GO:0051568)2.24417863
111skin morphogenesis (GO:0043589)2.23533635
112peptidyl-threonine phosphorylation (GO:0018107)2.22689464
113regulation of necroptotic process (GO:0060544)2.20116093
114regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.20035336
115apoptotic process involved in morphogenesis (GO:0060561)2.19249273
116nuclear pore organization (GO:0006999)2.18954700
117planar cell polarity pathway involved in neural tube closure (GO:0090179)2.18782159
118negative regulation of hormone biosynthetic process (GO:0032353)2.17941011
119negative regulation of hormone metabolic process (GO:0032351)2.17941011
120detection of molecule of bacterial origin (GO:0032490)2.17881472
121negative regulation of anoikis (GO:2000811)2.17233635
122detection of bacterium (GO:0016045)2.17151861
123positive regulation of SMAD protein import into nucleus (GO:0060391)2.16661859
124positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.15565053
125negative regulation of vascular permeability (GO:0043116)2.14615691
126intracellular estrogen receptor signaling pathway (GO:0030520)2.14374289
127blood vessel endothelial cell migration (GO:0043534)2.14154393
128Golgi transport vesicle coating (GO:0048200)2.13963979
129COPI coating of Golgi vesicle (GO:0048205)2.13963979
130macrophage activation involved in immune response (GO:0002281)2.13821828
131epithelial cell-cell adhesion (GO:0090136)2.13006539
132regulation of integrin activation (GO:0033623)2.12894520
133histone demethylation (GO:0016577)2.12748800
134cellular response to epidermal growth factor stimulus (GO:0071364)2.12642422
135gene silencing by RNA (GO:0031047)2.12200081
136intracellular lipid transport (GO:0032365)2.12064657
137activation of Rac GTPase activity (GO:0032863)2.11578179
138protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.11215017
139retina vasculature morphogenesis in camera-type eye (GO:0061299)2.10855706
140positive regulation of protein deacetylation (GO:0090312)2.10761105
141cellular response to fluid shear stress (GO:0071498)2.10731548
142regulation of lipid kinase activity (GO:0043550)2.10665591
143heterochromatin organization (GO:0070828)2.10316601
144surfactant homeostasis (GO:0043129)2.09889811
145regulation of T-helper 2 cell differentiation (GO:0045628)2.09861064
146positive regulation of Rap GTPase activity (GO:0032854)2.09772201
147substrate adhesion-dependent cell spreading (GO:0034446)2.09757396
148regulation of leukocyte degranulation (GO:0043300)2.09438881
149modulation by virus of host process (GO:0019054)2.09178286
150lipopolysaccharide-mediated signaling pathway (GO:0031663)2.08402162
151endocardial cushion development (GO:0003197)2.08298006
152regulation of p38MAPK cascade (GO:1900744)2.08178290
153establishment of nucleus localization (GO:0040023)2.07165825
154activation of JUN kinase activity (GO:0007257)2.06819845
155regulation of type I interferon-mediated signaling pathway (GO:0060338)2.06728655
156negative regulation of lipid transport (GO:0032369)2.06704029
157thymic T cell selection (GO:0045061)2.06258022
158regulation of gamma-delta T cell differentiation (GO:0045586)2.05773754
159response to UV-C (GO:0010225)2.04482545
160regulation of steroid hormone biosynthetic process (GO:0090030)2.04303587
161negative regulation of Rho protein signal transduction (GO:0035024)2.03655580
162regulation of SMAD protein import into nucleus (GO:0060390)2.02560942
163response to laminar fluid shear stress (GO:0034616)2.00955564
164genitalia morphogenesis (GO:0035112)1.99878389
165mesodermal cell differentiation (GO:0048333)1.99875427
166gastrulation with mouth forming second (GO:0001702)1.99292829
167cortical cytoskeleton organization (GO:0030865)1.98724059
168patterning of blood vessels (GO:0001569)1.98671886
169regulation of cholesterol storage (GO:0010885)1.98159401
170regulation of catenin import into nucleus (GO:0035412)1.98050869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.34383960
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61402874
3FOXM1_23109430_ChIP-Seq_U2OS_Human2.60543130
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.53271407
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.37087952
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11738621
7TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.07955338
8VDR_24763502_ChIP-Seq_THP-1_Human2.01397133
9KDM2B_26808549_Chip-Seq_DND41_Human2.00954085
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99161670
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97472748
12FOXO3_23340844_ChIP-Seq_DLD1_Human1.97260184
13KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93812158
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90866724
15TCF7_22412390_ChIP-Seq_EML_Mouse1.89402858
16CLOCK_20551151_ChIP-Seq_293T_Human1.87751123
17P300_27058665_Chip-Seq_ZR-75-30cells_Human1.83238584
18* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.82045870
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81978170
20KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.81891671
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76050834
22MAF_26560356_Chip-Seq_TH1_Human1.75369700
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74638743
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72735445
25KDM2B_26808549_Chip-Seq_JURKAT_Human1.71560515
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71050088
27MYC_22102868_ChIP-Seq_BL_Human1.68931815
28KDM2B_26808549_Chip-Seq_K562_Human1.68456473
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.65427238
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.63522168
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61621251
32TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61546595
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61191133
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60954840
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60133051
36LXR_22292898_ChIP-Seq_THP-1_Human1.59959885
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59220309
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57101147
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55293181
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54402903
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.53981837
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53177339
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52964961
44FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.50826985
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49533080
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49402931
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.48846329
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.45685132
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45456255
50SCL_19346495_ChIP-Seq_HPC-7_Human1.43588116
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43436470
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42572502
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42363305
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41738359
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41324211
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41089545
57E2F7_22180533_ChIP-Seq_HELA_Human1.40582236
58* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40340301
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40338556
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.39332357
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.38719859
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.38719859
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37430099
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36490185
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.36177402
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.35716727
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34208928
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.33071032
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32439176
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.31879011
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.31760594
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30117152
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30022453
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29753318
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29613711
76MYB_26560356_Chip-Seq_TH1_Human1.27963799
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.27914344
78ZNF263_19887448_ChIP-Seq_K562_Human1.26812800
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24470895
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.24342715
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.23592499
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23082741
83FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22623231
84TP53_16413492_ChIP-PET_HCT116_Human1.22090131
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21181921
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20903395
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20290128
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19541423
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19301681
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19268190
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19200862
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18758017
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.18359793
94MAF_26560356_Chip-Seq_TH2_Human1.18228865
95AR_21909140_ChIP-Seq_LNCAP_Human1.18173295
96BRD4_25478319_ChIP-Seq_HGPS_Human1.16611256
97SPI1_23127762_ChIP-Seq_K562_Human1.16399558
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16158438
99ATF3_27146783_Chip-Seq_COLON_Human1.15581877
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15423113
101RUNX_20019798_ChIP-Seq_JUKART_Human1.15406649
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14507445
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13690628
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.13165071
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.12585634
106CJUN_26792858_Chip-Seq_BT549_Human1.11882126
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11855342
108RACK7_27058665_Chip-Seq_MCF-7_Human1.11748633
109GATA6_25053715_ChIP-Seq_YYC3_Human1.11744155
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.10322011
111GATA1_19941826_ChIP-Seq_K562_Human1.10252331
112TP63_17297297_ChIP-ChIP_HaCaT_Human1.09933993
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09473593
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09142937
115IRF8_22096565_ChIP-ChIP_GC-B_Human1.08402667
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08267919
117SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07446357
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.07306241
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07251616
120RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06692050
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05920309
122UTX_26944678_Chip-Seq_JUKART_Human1.05600723
123CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04784853
124CREB1_26743006_Chip-Seq_LNCaP_Human1.04590598
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04132491
126BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02223764
127MYB_26560356_Chip-Seq_TH2_Human1.01288670
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00946905
129EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00653084
130PU_27001747_Chip-Seq_BMDM_Mouse1.00261611
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98376857
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98074215
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.97983373
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97900799
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97156294
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97156294
137NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96932478
138NCOR1_26117541_ChIP-Seq_K562_Human0.96782755
139VDR_21846776_ChIP-Seq_THP-1_Human0.96374220
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94687060
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94451364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.55373211
2MP0005076_abnormal_cell_differentiation2.86756314
3MP0004185_abnormal_adipocyte_glucose2.67580115
4MP0008438_abnormal_cutaneous_collagen2.64356243
5MP0003300_gastrointestinal_ulcer2.62136408
6MP0010352_gastrointestinal_tract_polyps2.40254638
7MP0005623_abnormal_meninges_morphology2.37740135
8MP0001849_ear_inflammation2.27834341
9MP0003566_abnormal_cell_adhesion2.27220531
10MP0004272_abnormal_basement_membrane2.23356046
11MP0003436_decreased_susceptibility_to2.19547126
12MP0002877_abnormal_melanocyte_morpholog2.17611078
13MP0010234_abnormal_vibrissa_follicle2.16119711
14MP0002009_preneoplasia2.15948873
15MP0000733_abnormal_muscle_development2.14510526
16MP0005409_darkened_coat_color2.10213694
17MP0003303_peritoneal_inflammation2.07836528
18MP0005058_abnormal_lysosome_morphology1.95972550
19MP0000569_abnormal_digit_pigmentation1.94544432
20MP0008057_abnormal_DNA_replication1.92372894
21MP0008961_abnormal_basal_metabolism1.90537376
22MP0003828_pulmonary_edema1.85240388
23MP0003091_abnormal_cell_migration1.84767779
24MP0008260_abnormal_autophagy1.82368123
25MP0009053_abnormal_anal_canal1.76892004
26MP0003763_abnormal_thymus_physiology1.76187505
27MP0009384_cardiac_valve_regurgitation1.74492174
28MP0002796_impaired_skin_barrier1.74387186
29MP0002396_abnormal_hematopoietic_system1.69211449
30MP0003172_abnormal_lysosome_physiology1.68304238
31MP0005666_abnormal_adipose_tissue1.67394474
32MP0000003_abnormal_adipose_tissue1.65932653
33MP0003191_abnormal_cellular_cholesterol1.62760790
34MP0010307_abnormal_tumor_latency1.56703823
35MP0004130_abnormal_muscle_cell1.55217695
36MP0003045_fibrosis1.52962532
37MP0000428_abnormal_craniofacial_morphol1.52303805
38MP0001299_abnormal_eye_distance/1.51794208
39MP0005375_adipose_tissue_phenotype1.51483083
40MP0003252_abnormal_bile_duct1.51199084
41MP0009840_abnormal_foam_cell1.49093847
42MP0001915_intracranial_hemorrhage1.48126582
43MP0009780_abnormal_chondrocyte_physiolo1.46999435
44MP0005257_abnormal_intraocular_pressure1.46631470
45MP0000858_altered_metastatic_potential1.46115166
46MP0004381_abnormal_hair_follicle1.42983360
47MP0010630_abnormal_cardiac_muscle1.41264241
48MP0009278_abnormal_bone_marrow1.40165676
49MP0003115_abnormal_respiratory_system1.39668266
50MP0002925_abnormal_cardiovascular_devel1.39106101
51MP0002998_abnormal_bone_remodeling1.38292338
52MP0005275_abnormal_skin_tensile1.35092244
53MP0001958_emphysema1.31270355
54MP0003385_abnormal_body_wall1.30794422
55MP0001730_embryonic_growth_arrest1.29892405
56MP0002084_abnormal_developmental_patter1.26102608
57MP0003984_embryonic_growth_retardation1.26060951
58MP0002088_abnormal_embryonic_growth/wei1.24538297
59MP0000767_abnormal_smooth_muscle1.24250520
60MP0010678_abnormal_skin_adnexa1.22156789
61MP0010368_abnormal_lymphatic_system1.19585961
62MP0004510_myositis1.19215972
63MP0002086_abnormal_extraembryonic_tissu1.19025683
64MP0005023_abnormal_wound_healing1.18509748
65MP0000537_abnormal_urethra_morphology1.17535690
66MP0005380_embryogenesis_phenotype1.16538432
67MP0001672_abnormal_embryogenesis/_devel1.16538432
68MP0002419_abnormal_innate_immunity1.15971744
69MP0005621_abnormal_cell_physiology1.15893158
70MP0000685_abnormal_immune_system1.15637568
71MP0003935_abnormal_craniofacial_develop1.12731462
72MP0005000_abnormal_immune_tolerance1.11969622
73MP0004264_abnormal_extraembryonic_tissu1.11346151
74MP0004197_abnormal_fetal_growth/weight/1.11142478
75MP0004087_abnormal_muscle_fiber1.10997337
76MP0003656_abnormal_erythrocyte_physiolo1.10856964
77MP0001614_abnormal_blood_vessel1.09465167
78MP0005464_abnormal_platelet_physiology1.07901588
79MP0001835_abnormal_antigen_presentation1.07616852
80MP0002398_abnormal_bone_marrow1.06909260
81MP0002405_respiratory_system_inflammati1.06694782
82MP0005248_abnormal_Harderian_gland1.06629613
83MP0005397_hematopoietic_system_phenotyp1.06477533
84MP0001545_abnormal_hematopoietic_system1.06477533
85MP0001879_abnormal_lymphatic_vessel1.05637707
86MP0005187_abnormal_penis_morphology1.05276355
87MP0006054_spinal_hemorrhage1.05186028
88MP0009333_abnormal_splenocyte_physiolog1.03896575
89MP0002085_abnormal_embryonic_tissue1.03878705
90MP0001800_abnormal_humoral_immune1.03634445
91MP0003937_abnormal_limbs/digits/tail_de1.03481161
92MP0002092_abnormal_eye_morphology1.02952395
93MP0003279_aneurysm1.01425598
94MP0001853_heart_inflammation1.01269917
95MP0000703_abnormal_thymus_morphology1.00891068
96MP0009115_abnormal_fat_cell0.99946555
97MP0005501_abnormal_skin_physiology0.99190897
98MP0002168_other_aberrant_phenotype0.98966888
99MP0009672_abnormal_birth_weight0.98847947
100MP0001697_abnormal_embryo_size0.98660589
101MP0002006_tumorigenesis0.98214806
102MP0006138_congestive_heart_failure0.97819726
103MP0010155_abnormal_intestine_physiology0.96278850
104MP0000266_abnormal_heart_morphology0.96028592
105MP0005408_hypopigmentation0.95663256
106MP0005025_abnormal_response_to0.95653481
107MP0005167_abnormal_blood-brain_barrier0.95504099
108MP0005451_abnormal_body_composition0.95075177
109MP0004233_abnormal_muscle_weight0.94454410
110MP0001216_abnormal_epidermal_layer0.94082667
111MP0002452_abnormal_antigen_presenting0.94043901
112MP0001533_abnormal_skeleton_physiology0.93658272
113MP0000432_abnormal_head_morphology0.93488778
114MP0002128_abnormal_blood_circulation0.92125303
115MP0002896_abnormal_bone_mineralization0.91842062
116MP0002697_abnormal_eye_size0.91331485
117MP0009703_decreased_birth_body0.91211747
118MP0002420_abnormal_adaptive_immunity0.91106054
119MP0008004_abnormal_stomach_pH0.90349800
120MP0001819_abnormal_immune_cell0.90189874
121MP0001790_abnormal_immune_system0.88154489
122MP0005387_immune_system_phenotype0.88154489
123MP0003890_abnormal_embryonic-extraembry0.87730760
124MP0002722_abnormal_immune_system0.87437475
125MP0003453_abnormal_keratinocyte_physiol0.86941159
126MP0009931_abnormal_skin_appearance0.86572514
127MP0002089_abnormal_postnatal_growth/wei0.86570121
128MP0002723_abnormal_immune_serum0.86535289
129MP0001293_anophthalmia0.85719710
130MP0000716_abnormal_immune_system0.84929466
131MP0004084_abnormal_cardiac_muscle0.84367409
132MP0003724_increased_susceptibility_to0.84082473
133MP0001348_abnormal_lacrimal_gland0.83307734
134MP0004808_abnormal_hematopoietic_stem0.81497880
135MP0000350_abnormal_cell_proliferation0.80750884
136MP0005360_urolithiasis0.79872253
137MP0002653_abnormal_ependyma_morphology0.79338594
138MP0004947_skin_inflammation0.79145919
139MP0002429_abnormal_blood_cell0.77638288
140MP0002132_abnormal_respiratory_system0.76771672
141MP0002060_abnormal_skin_morphology0.76052927
142MP0003283_abnormal_digestive_organ0.75738013
143MP0003868_abnormal_feces_composition0.75077706
144MP0001784_abnormal_fluid_regulation0.74561852
145MP0002971_abnormal_brown_adipose0.74115938
146MP0008770_decreased_survivor_rate0.70369843
147MP0000377_abnormal_hair_follicle0.70271904
148MP0000383_abnormal_hair_follicle0.70107324
149MP0000747_muscle_weakness0.70106234
150MP0002166_altered_tumor_susceptibility0.69363464
151MP0000534_abnormal_ureter_morphology0.67996987
152MP0000579_abnormal_nail_morphology0.66787386
153MP0001851_eye_inflammation0.66241053
154MP0003755_abnormal_palate_morphology0.65932761

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.51252358
2Shallow orbits (HP:0000586)3.28334468
3Protrusio acetabuli (HP:0003179)2.85355264
4Broad face (HP:0000283)2.76396725
5Hyperacusis (HP:0010780)2.76238130
6Premature rupture of membranes (HP:0001788)2.72544923
7Mitral valve prolapse (HP:0001634)2.72492584
8Aortic aneurysm (HP:0004942)2.69847993
9Broad metatarsal (HP:0001783)2.62721047
10Eczematoid dermatitis (HP:0000976)2.57128858
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54851845
12Short 4th metacarpal (HP:0010044)2.54851845
13Aneurysm (HP:0002617)2.52572921
14Flat acetabular roof (HP:0003180)2.48133560
15Peritonitis (HP:0002586)2.47506956
16Subacute progressive viral hepatitis (HP:0006572)2.47284971
17Ankle contracture (HP:0006466)2.47151369
18Ulnar bowing (HP:0003031)2.46239425
19Renovascular hypertension (HP:0100817)2.45815793
20Heterotopia (HP:0002282)2.45793295
21Macroorchidism (HP:0000053)2.45376148
22Spinal cord lesions (HP:0100561)2.42162295
23Syringomyelia (HP:0003396)2.42162295
24Hypoplastic ischia (HP:0003175)2.41309454
25Abnormality of the fingertips (HP:0001211)2.40617097
26Aortic dissection (HP:0002647)2.35441204
27Striae distensae (HP:0001065)2.34558803
28Renal duplication (HP:0000075)2.33301834
29Obstructive sleep apnea (HP:0002870)2.29534311
30Dilatation of the ascending aorta (HP:0005111)2.27626861
31Bladder diverticulum (HP:0000015)2.22113863
32Genu recurvatum (HP:0002816)2.16125910
33Increased IgE level (HP:0003212)2.15756068
34Abnormality of the 4th metacarpal (HP:0010012)2.15468652
35Abnormality of the ischium (HP:0003174)2.15451952
36Narrow palate (HP:0000189)2.11546975
37Hematochezia (HP:0002573)2.10404298
38Elfin facies (HP:0004428)2.09208535
39Long eyelashes (HP:0000527)2.09189200
40Dislocated radial head (HP:0003083)2.08606029
41Buphthalmos (HP:0000557)2.06990348
42Myocardial infarction (HP:0001658)2.06452157
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.04914787
44Osteolytic defects of the hand bones (HP:0009699)2.04914787
45Abnormality of the distal phalanx of the thumb (HP:0009617)2.04211829
46Hallux valgus (HP:0001822)2.03704101
47Interstitial pulmonary disease (HP:0006530)2.02941903
48Overriding aorta (HP:0002623)2.02374430
49Deviation of the hallux (HP:0010051)2.02197693
50Arterial tortuosity (HP:0005116)2.01441124
51Bowel diverticulosis (HP:0005222)1.97230428
52Termporal pattern (HP:0011008)1.93747456
53Insidious onset (HP:0003587)1.93747456
54Polycythemia (HP:0001901)1.91869873
55Abnormality of the thoracic spine (HP:0100711)1.91533032
56Persistence of primary teeth (HP:0006335)1.91258599
57Fatigue (HP:0012378)1.90578325
58Papillary thyroid carcinoma (HP:0002895)1.90422476
59Cellulitis (HP:0100658)1.90368838
60Abnormality of the radial head (HP:0003995)1.89704628
61Slow saccadic eye movements (HP:0000514)1.89121421
62Abnormality of macrophages (HP:0004311)1.88717132
63Hyporeflexia of lower limbs (HP:0002600)1.88402943
64Turricephaly (HP:0000262)1.88382127
65Camptodactyly of toe (HP:0001836)1.88020761
66Deep venous thrombosis (HP:0002625)1.87713207
67Difficulty running (HP:0009046)1.86408553
68Distal lower limb amyotrophy (HP:0008944)1.86155029
69Upper limb amyotrophy (HP:0009129)1.85368046
70Distal upper limb amyotrophy (HP:0007149)1.85368046
71Vascular tortuosity (HP:0004948)1.85261078
72Lymphangioma (HP:0100764)1.83056809
73Sparse lateral eyebrow (HP:0005338)1.82429868
74Bicuspid aortic valve (HP:0001647)1.81266619
75Coronal craniosynostosis (HP:0004440)1.80474166
76Long toe (HP:0010511)1.79572268
77Colitis (HP:0002583)1.79565880
78Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79545846
79Germ cell neoplasia (HP:0100728)1.79444254
80Long palpebral fissure (HP:0000637)1.78747669
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77300457
82Deep philtrum (HP:0002002)1.77242884
83Advanced eruption of teeth (HP:0006288)1.76910432
84Vertebral arch anomaly (HP:0008438)1.76862490
85Segmental peripheral demyelination/remyelination (HP:0003481)1.76672955
86Pseudobulbar signs (HP:0002200)1.76638361
87Broad thumb (HP:0011304)1.76574126
88Vertebral compression fractures (HP:0002953)1.75617639
89Spastic diplegia (HP:0001264)1.73488485
90Disproportionate tall stature (HP:0001519)1.73255457
91Viral hepatitis (HP:0006562)1.71056214
92Abnormality of the peritoneum (HP:0002585)1.70985828
93Male infertility (HP:0003251)1.70478578
94Neonatal hypoglycemia (HP:0001998)1.69874587
95Hypoplastic labia majora (HP:0000059)1.69356048
96Atrophic scars (HP:0001075)1.68187995
97Abnormality of the common coagulation pathway (HP:0010990)1.67785931
98Insomnia (HP:0100785)1.65331399
99Abnormality of the lower motor neuron (HP:0002366)1.64942843
100Thoracic kyphosis (HP:0002942)1.64526085
101Thin bony cortex (HP:0002753)1.64243172
102Dysmetric saccades (HP:0000641)1.64221085
103Cervical subluxation (HP:0003308)1.64106495
104Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.63785482
105Flat cornea (HP:0007720)1.63103089
106Ankyloglossia (HP:0010296)1.63083256
107Enlarged penis (HP:0000040)1.62681803
108Esophageal varix (HP:0002040)1.62523396
109Increased density of long bones (HP:0006392)1.62470461
110Abnormality of the diencephalon (HP:0010662)1.61078901
111Scapular winging (HP:0003691)1.60489710
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60270548
113Fibroma (HP:0010614)1.60098192
114Obsessive-compulsive behavior (HP:0000722)1.60080714
115Abnormality of the lumbar spine (HP:0100712)1.59761203
116Midline defect of the nose (HP:0004122)1.59247406
117Abnormality of oral frenula (HP:0000190)1.59021727
118Increased variability in muscle fiber diameter (HP:0003557)1.58848649
119Fibrous tissue neoplasm (HP:0012316)1.58685888
120Coarse hair (HP:0002208)1.57935442
121Centrally nucleated skeletal muscle fibers (HP:0003687)1.57933230
122Asymmetry of the thorax (HP:0001555)1.57370967
123Bowed forearm bones (HP:0003956)1.57040954
124Bowing of the arm (HP:0006488)1.57040954
125Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57006112
126Spontaneous hematomas (HP:0007420)1.56502929
127Trigonocephaly (HP:0000243)1.56286164
128Gingivitis (HP:0000230)1.56234506
129Increased connective tissue (HP:0009025)1.55587487
130Spondylolisthesis (HP:0003302)1.55564542
131Absent frontal sinuses (HP:0002688)1.55505972
132Mitral regurgitation (HP:0001653)1.54744220
133Deep palmar crease (HP:0006191)1.54199997
134Urethral obstruction (HP:0000796)1.53677924
135Recurrent bacterial skin infections (HP:0005406)1.53286429
136Arnold-Chiari malformation (HP:0002308)1.53153321
137Leiomyosarcoma (HP:0100243)1.53066125
138Uterine leiomyosarcoma (HP:0002891)1.53066125
139Transitional cell carcinoma of the bladder (HP:0006740)1.52111592
140Abnormality of the astrocytes (HP:0100707)1.51923751
141Astrocytoma (HP:0009592)1.51923751
142Micronodular cirrhosis (HP:0001413)1.51877206
143Tibial bowing (HP:0002982)1.51868530
144Hypercortisolism (HP:0001578)1.51642033
145Hemorrhage of the eye (HP:0011885)1.51572300
146Exostoses (HP:0100777)1.51231534
147Abnormality of skeletal muscle fiber size (HP:0012084)1.50899792
148Renal cell carcinoma (HP:0005584)1.50419983
149Polygenic inheritance (HP:0010982)1.49775490
150Recurrent abscess formation (HP:0002722)1.49421232
151Metaphyseal cupping (HP:0003021)1.49271542
152Recurrent viral infections (HP:0004429)1.48746100
153Dysostosis multiplex (HP:0000943)1.48731463
154Abnormal foot bone ossification (HP:0010675)1.48473270
155Prolonged bleeding time (HP:0003010)1.46039875
156Lip pit (HP:0100267)1.45153544
157Right ventricular cardiomyopathy (HP:0011663)1.44794404
158Abnormal ossification of hand bones (HP:0005921)1.43468996
159Natal tooth (HP:0000695)1.43067643
160Acute myeloid leukemia (HP:0004808)1.42946665
161Neuronal loss in central nervous system (HP:0002529)1.42393178
162Gastrointestinal inflammation (HP:0004386)1.42363368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.24237137
2PRPF4B4.20120104
3TRIB33.51530554
4CDK122.83199873
5LATS22.58414877
6EEF2K2.53301475
7PKN22.43938302
8SMG12.17129114
9PDGFRA2.15286944
10PRKD32.12395976
11STK32.10824693
12CAMK1D2.09820727
13TTN2.08240032
14CAMK1G2.05256053
15KSR21.92571510
16DMPK1.84226220
17IRAK31.84078475
18MAP3K101.78432808
19PDGFRB1.68381028
20MAP2K31.65329499
21PTK61.63979026
22RIPK11.62391073
23SIK11.57970533
24STK381.55701325
25MAP3K141.51828573
26TYRO31.47091672
27TAOK11.46739240
28PAK61.44131828
29RIPK41.38248530
30ICK1.37262347
31FGFR21.35749747
32STK38L1.34584479
33EPHB11.30918340
34ZAP701.29541450
35MTOR1.29271710
36DDR21.29068848
37BMX1.28753420
38MAP3K31.24097335
39RET1.21606172
40STK101.17283343
41NEK21.16595472
42MAP3K91.13445428
43CDC42BPA1.11912988
44SIK31.11886465
45IRAK41.10850227
46ERN11.10318084
47MAP4K11.09663502
48MAP3K11.09289273
49PAK21.03966761
50IRAK21.03792730
51PTK21.00130228
52LRRK20.96714213
53PRKD20.94389706
54ERBB40.93511079
55FGFR40.92495806
56TBK10.90472188
57ALK0.90440477
58PRKCH0.88692319
59PAK30.86265369
60MAP3K20.85799544
61FGFR30.85326712
62MAPK70.82186930
63TAOK30.80771009
64MELK0.79701263
65CDK60.79212504
66TAOK20.79175786
67JAK10.77810230
68MARK20.77636281
69EPHB20.77420853
70CSK0.76678019
71SGK20.76542011
72CDC70.75999184
73IRAK10.74784787
74YES10.72168239
75BLK0.71456136
76MET0.71243866
77RPS6KB20.68982777
78BRD40.66950172
79PTK2B0.66280550
80CDK40.65913895
81EPHA20.65363700
82MAP3K70.65347344
83KSR10.65306925
84FGFR10.64660131
85WNK10.63003043
86RPS6KA20.62624875
87IKBKE0.62441901
88AKT30.61656291
89JAK30.61584182
90NEK90.61374038
91NTRK10.61263572
92TRPM70.60966341
93RPS6KL10.60210824
94RPS6KC10.60210824
95NLK0.59678833
96JAK20.59243754
97MOS0.58857445
98PRKD10.58183874
99TGFBR20.56420426
100MAP3K80.56151463
101MAP3K130.54688508
102SGK30.54578980
103NEK60.54441622
104HCK0.54032049
105BTK0.53871849
106PRKAA20.52496555
107PDK40.51486785
108PDK30.51486785
109TESK10.51413706
110PAK40.51387946
111RAF10.51085673
112CDK70.48953250
113FRK0.48757154
114SGK2230.47803849
115SGK4940.47803849
116MAP3K60.47204566
117CSF1R0.46909998
118CDK90.46470730
119ABL20.46136451
120MAPK120.46129064
121FGR0.45629977
122PDPK10.45561690
123ABL10.45085166
124CLK10.44388857
125MAPK110.44077935
126PRKAA10.43384787
127CSNK1D0.42190501
128SIK20.40826266
129MAP3K40.40626634
130EGFR0.38886264
131SCYL20.38181612
132TYK20.38011608
133MAPK100.37380695
134GSK3A0.35392246
135NUAK10.35278043
136PDK10.35187564
137FER0.34263147
138INSR0.33926686
139CHUK0.33760798
140HIPK20.30966480
141NTRK20.30573846
142CHEK10.30375616
143ROCK10.29999208

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.08465829
2Other glycan degradation_Homo sapiens_hsa005111.80636467
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77987723
4Dorso-ventral axis formation_Homo sapiens_hsa043201.75849016
5Chronic myeloid leukemia_Homo sapiens_hsa052201.71708574
6Adherens junction_Homo sapiens_hsa045201.67363901
7Lysine degradation_Homo sapiens_hsa003101.65983623
8Focal adhesion_Homo sapiens_hsa045101.53886248
9mTOR signaling pathway_Homo sapiens_hsa041501.51804364
10Proteoglycans in cancer_Homo sapiens_hsa052051.49833539
11Pancreatic cancer_Homo sapiens_hsa052121.46806300
12MicroRNAs in cancer_Homo sapiens_hsa052061.46255114
13Small cell lung cancer_Homo sapiens_hsa052221.43199327
14Renal cell carcinoma_Homo sapiens_hsa052111.41644781
15ECM-receptor interaction_Homo sapiens_hsa045121.36264361
16Glioma_Homo sapiens_hsa052141.34880461
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34522030
18Endometrial cancer_Homo sapiens_hsa052131.30957629
19Non-small cell lung cancer_Homo sapiens_hsa052231.30946262
20Leishmaniasis_Homo sapiens_hsa051401.25285957
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24913690
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24006630
23Influenza A_Homo sapiens_hsa051641.22298493
24Hepatitis C_Homo sapiens_hsa051601.21875843
25Type II diabetes mellitus_Homo sapiens_hsa049301.19784496
26Hippo signaling pathway_Homo sapiens_hsa043901.19737622
27Insulin resistance_Homo sapiens_hsa049311.18756464
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18378178
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.16522291
30VEGF signaling pathway_Homo sapiens_hsa043701.15695020
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15436307
32Measles_Homo sapiens_hsa051621.12926053
33Amoebiasis_Homo sapiens_hsa051461.12165294
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11655104
35Estrogen signaling pathway_Homo sapiens_hsa049151.06174829
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02551275
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02177090
38TGF-beta signaling pathway_Homo sapiens_hsa043501.01961117
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.01643288
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.01321402
41Apoptosis_Homo sapiens_hsa042101.00651875
42Bladder cancer_Homo sapiens_hsa052191.00429536
43B cell receptor signaling pathway_Homo sapiens_hsa046620.99876541
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99656247
45Prostate cancer_Homo sapiens_hsa052150.99650671
46Colorectal cancer_Homo sapiens_hsa052100.99010449
47Viral myocarditis_Homo sapiens_hsa054160.98390925
48Notch signaling pathway_Homo sapiens_hsa043300.98226328
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97815002
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96823374
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96212470
52Dilated cardiomyopathy_Homo sapiens_hsa054140.95141309
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94656109
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.93587078
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.93214069
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92743953
57Arginine biosynthesis_Homo sapiens_hsa002200.91988785
58Bile secretion_Homo sapiens_hsa049760.91955966
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91363572
60Herpes simplex infection_Homo sapiens_hsa051680.90861242
61Toxoplasmosis_Homo sapiens_hsa051450.90457872
62Prolactin signaling pathway_Homo sapiens_hsa049170.90286471
63Rap1 signaling pathway_Homo sapiens_hsa040150.90166155
64Basal cell carcinoma_Homo sapiens_hsa052170.89128883
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.88990927
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88700980
67Tuberculosis_Homo sapiens_hsa051520.88547041
68ErbB signaling pathway_Homo sapiens_hsa040120.88441300
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.87332336
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86609257
71Tight junction_Homo sapiens_hsa045300.85889782
72Insulin signaling pathway_Homo sapiens_hsa049100.85421863
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.85304270
74Fatty acid biosynthesis_Homo sapiens_hsa000610.83676882
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.83076300
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82680116
77Malaria_Homo sapiens_hsa051440.82485018
78Platelet activation_Homo sapiens_hsa046110.81532150
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80532958
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79465446
81AMPK signaling pathway_Homo sapiens_hsa041520.78866215
82PPAR signaling pathway_Homo sapiens_hsa033200.78035735
83Prion diseases_Homo sapiens_hsa050200.77706916
84Choline metabolism in cancer_Homo sapiens_hsa052310.77453141
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77056348
86Acute myeloid leukemia_Homo sapiens_hsa052210.75822297
87Osteoclast differentiation_Homo sapiens_hsa043800.74802677
88Shigellosis_Homo sapiens_hsa051310.74480902
89Glucagon signaling pathway_Homo sapiens_hsa049220.74141043
90FoxO signaling pathway_Homo sapiens_hsa040680.74092104
91Pathways in cancer_Homo sapiens_hsa052000.73633714
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73625745
93Thyroid cancer_Homo sapiens_hsa052160.72754660
94Endocytosis_Homo sapiens_hsa041440.72631058
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72483686
96Staphylococcus aureus infection_Homo sapiens_hsa051500.70822115
97GnRH signaling pathway_Homo sapiens_hsa049120.70500694
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70474981
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68051316
100Melanogenesis_Homo sapiens_hsa049160.67498208
101MAPK signaling pathway_Homo sapiens_hsa040100.65899948
102Inositol phosphate metabolism_Homo sapiens_hsa005620.65025630
103Hedgehog signaling pathway_Homo sapiens_hsa043400.63976025
104Chemokine signaling pathway_Homo sapiens_hsa040620.60558826
105HTLV-I infection_Homo sapiens_hsa051660.59807766
106Ras signaling pathway_Homo sapiens_hsa040140.59788006
107Melanoma_Homo sapiens_hsa052180.59550193
108mRNA surveillance pathway_Homo sapiens_hsa030150.59426294
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58401641
110Epstein-Barr virus infection_Homo sapiens_hsa051690.57415114
111Pertussis_Homo sapiens_hsa051330.57208332
112TNF signaling pathway_Homo sapiens_hsa046680.56525855
113HIF-1 signaling pathway_Homo sapiens_hsa040660.56022286
114Wnt signaling pathway_Homo sapiens_hsa043100.55195844
115Legionellosis_Homo sapiens_hsa051340.54666411
116Lysosome_Homo sapiens_hsa041420.54633968
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54443808
118Thyroid hormone synthesis_Homo sapiens_hsa049180.53903131
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53236570
120Axon guidance_Homo sapiens_hsa043600.53023727
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52433602
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52420331
123Hepatitis B_Homo sapiens_hsa051610.51988841
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51925017
125Complement and coagulation cascades_Homo sapiens_hsa046100.51631425
126Gap junction_Homo sapiens_hsa045400.51383900
127Viral carcinogenesis_Homo sapiens_hsa052030.49105323
128Long-term potentiation_Homo sapiens_hsa047200.49090145
129T cell receptor signaling pathway_Homo sapiens_hsa046600.48797000
130Renin secretion_Homo sapiens_hsa049240.48792609
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48481037

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