ATXN2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.02858590
2pre-miRNA processing (GO:0031054)4.63836700
3regulation of histone H3-K27 methylation (GO:0061085)4.45429129
4heterochromatin organization (GO:0070828)4.00722337
5nuclear pore complex assembly (GO:0051292)3.90996923
6intracellular estrogen receptor signaling pathway (GO:0030520)3.85350566
7mannose metabolic process (GO:0006013)3.80684644
8COPI coating of Golgi vesicle (GO:0048205)3.60396391
9Golgi transport vesicle coating (GO:0048200)3.60396391
10positive regulation of histone deacetylation (GO:0031065)3.50352967
11NLS-bearing protein import into nucleus (GO:0006607)3.50234894
12nuclear pore organization (GO:0006999)3.49225208
13gene silencing by RNA (GO:0031047)3.48974044
14regulation of early endosome to late endosome transport (GO:2000641)3.47749301
15negative regulation of histone methylation (GO:0031061)3.46882954
163-UTR-mediated mRNA stabilization (GO:0070935)3.43540138
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.38551866
18activation of Rac GTPase activity (GO:0032863)3.38541065
19adherens junction assembly (GO:0034333)3.38184514
20focal adhesion assembly (GO:0048041)3.37992768
21cell-substrate adherens junction assembly (GO:0007045)3.37992768
22regulation of chromatin binding (GO:0035561)3.36641058
23regulation of NFAT protein import into nucleus (GO:0051532)3.34717879
24DNA unwinding involved in DNA replication (GO:0006268)3.34655921
25dosage compensation (GO:0007549)3.33063621
26nucleosome disassembly (GO:0006337)3.32941444
27protein-DNA complex disassembly (GO:0032986)3.32941444
28gene silencing (GO:0016458)3.30902318
29establishment of apical/basal cell polarity (GO:0035089)3.29888435
30mRNA stabilization (GO:0048255)3.29559981
31RNA stabilization (GO:0043489)3.29559981
32mitotic sister chromatid cohesion (GO:0007064)3.26895665
33regulation of RNA export from nucleus (GO:0046831)3.22675678
34peptidyl-lysine dimethylation (GO:0018027)3.19129386
35regulation of translational fidelity (GO:0006450)3.19048611
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18830123
37glucocorticoid receptor signaling pathway (GO:0042921)3.18100594
38histone H4-K12 acetylation (GO:0043983)3.17822627
39embryonic process involved in female pregnancy (GO:0060136)3.16604154
40paraxial mesoderm development (GO:0048339)3.09280078
41histone H3-K36 demethylation (GO:0070544)3.07039685
42negative regulation of cell size (GO:0045792)3.06128112
43thymic T cell selection (GO:0045061)3.04836647
44positive regulation of gene expression, epigenetic (GO:0045815)3.04319087
45epithelial cell fate commitment (GO:0072148)3.03574754
46positive thymic T cell selection (GO:0045059)3.00400262
47histone H3-K4 methylation (GO:0051568)3.00177104
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99869491
49cellular response to epidermal growth factor stimulus (GO:0071364)2.99800293
50lung epithelium development (GO:0060428)2.98517411
51modulation by virus of host process (GO:0019054)2.96507340
52synaptonemal complex assembly (GO:0007130)2.95759396
53histone H4-K5 acetylation (GO:0043981)2.93141983
54histone H4-K8 acetylation (GO:0043982)2.93141983
55histone H4-K16 acetylation (GO:0043984)2.93065904
56protein retention in ER lumen (GO:0006621)2.92395726
57proline biosynthetic process (GO:0006561)2.92217631
58regulation of glucose import in response to insulin stimulus (GO:2001273)2.91116376
59positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.90867281
60modulation by symbiont of host cellular process (GO:0044068)2.90570943
61apoptotic process involved in morphogenesis (GO:0060561)2.88359640
62regulation of cholesterol homeostasis (GO:2000188)2.87866453
63retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87158107
64activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.84504418
65RNA localization (GO:0006403)2.84289265
66sister chromatid segregation (GO:0000819)2.83890506
67spliceosomal tri-snRNP complex assembly (GO:0000244)2.82049265
68cytoplasmic mRNA processing body assembly (GO:0033962)2.81514860
69positive regulation of nuclease activity (GO:0032075)2.80656534
70pore complex assembly (GO:0046931)2.78591348
71chromatin silencing (GO:0006342)2.77154669
72response to laminar fluid shear stress (GO:0034616)2.76802764
73establishment or maintenance of monopolar cell polarity (GO:0061339)2.76522186
74establishment of monopolar cell polarity (GO:0061162)2.76522186
75histone H4 deacetylation (GO:0070933)2.76174479
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75306303
77translesion synthesis (GO:0019985)2.75089199
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74961655
79embryonic foregut morphogenesis (GO:0048617)2.74440787
80synaptonemal complex organization (GO:0070193)2.74239970
81activation of MAPKKK activity (GO:0000185)2.74006238
82response to muramyl dipeptide (GO:0032495)2.73555443
83negative regulation of mRNA metabolic process (GO:1903312)2.73217674
84regulation of ARF GTPase activity (GO:0032312)2.73114627
85protein localization to chromosome, centromeric region (GO:0071459)2.72466543
86negative regulation of gene expression, epigenetic (GO:0045814)2.71604827
87response to epidermal growth factor (GO:0070849)2.70578347
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69600539
89maternal placenta development (GO:0001893)2.69559055
90histone H3-K9 demethylation (GO:0033169)2.68239582
91mitotic nuclear envelope disassembly (GO:0007077)2.68037744
92cell-cell junction maintenance (GO:0045217)2.67416412
93glucose 6-phosphate metabolic process (GO:0051156)2.66233723
94histone lysine demethylation (GO:0070076)2.66059682
95cell-substrate junction assembly (GO:0007044)2.64807653
96protein export from nucleus (GO:0006611)2.63935717
97histone H4 acetylation (GO:0043967)2.63338258
98regulation of nucleobase-containing compound transport (GO:0032239)2.63025071
99negative regulation of mRNA processing (GO:0050686)2.62607156
100positive regulation of tolerance induction (GO:0002645)2.62603388
101mitotic sister chromatid segregation (GO:0000070)2.62339605
102positive regulation of RNA splicing (GO:0033120)2.62095358
103poly(A)+ mRNA export from nucleus (GO:0016973)2.62000282
104negative regulation of glial cell proliferation (GO:0060253)2.61910334
105histone H2A monoubiquitination (GO:0035518)2.61670630
106corticosteroid receptor signaling pathway (GO:0031958)2.60184251
107histone lysine methylation (GO:0034968)2.59787444
108protein localization to endosome (GO:0036010)2.59780680
109protein localization to kinetochore (GO:0034501)2.59458931
110regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59144027
111negative regulation of RNA splicing (GO:0033119)2.58462770
112semaphorin-plexin signaling pathway (GO:0071526)2.58106774
113regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.56615875
114membrane disassembly (GO:0030397)2.56539941
115nuclear envelope disassembly (GO:0051081)2.56539941
116response to pheromone (GO:0019236)2.55044293
117regulation of nuclease activity (GO:0032069)2.54779217
118regulation of extracellular matrix disassembly (GO:0010715)2.53300042
119histone demethylation (GO:0016577)2.52572784
120regulation of hippo signaling (GO:0035330)2.52128108
121planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51553844
122regulation of histone H3-K9 methylation (GO:0051570)2.50005982
123piRNA metabolic process (GO:0034587)2.49854101
124regulation of mRNA stability (GO:0043488)2.49438470
125Peyers patch development (GO:0048541)2.49311107
126mucosal-associated lymphoid tissue development (GO:0048537)2.49311107
127regulation of sister chromatid cohesion (GO:0007063)2.48581245
128peptidyl-arginine omega-N-methylation (GO:0035247)2.47372225
129axon extension involved in axon guidance (GO:0048846)2.46957599
130neuron projection extension involved in neuron projection guidance (GO:1902284)2.46957599
131coronary vasculature morphogenesis (GO:0060977)2.46619435
132apoptotic process involved in development (GO:1902742)2.46569242
133negative regulation of myotube differentiation (GO:0010832)2.46452852
134positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45886615
135endoplasmic reticulum unfolded protein response (GO:0030968)2.45283896
136intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.45148103
137tolerance induction (GO:0002507)2.44883326
138internal peptidyl-lysine acetylation (GO:0018393)2.44352103
139regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.44186757
140negative regulation of viral release from host cell (GO:1902187)2.44061140
141G1 DNA damage checkpoint (GO:0044783)2.43515248
142stress fiber assembly (GO:0043149)2.43282535
143histone methylation (GO:0016571)2.43148101
144positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.42864027
145mitotic chromosome condensation (GO:0007076)2.42704398
146regulation of stem cell maintenance (GO:2000036)2.42350608
147modulation by virus of host morphology or physiology (GO:0019048)2.40177634
148regulation of RNA stability (GO:0043487)2.39749531
149peptidyl-arginine methylation (GO:0018216)2.39703638
150peptidyl-arginine N-methylation (GO:0035246)2.39703638
151ER-nucleus signaling pathway (GO:0006984)2.39358526
152mitotic G1 DNA damage checkpoint (GO:0031571)2.39102791
153regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38763460
154positive regulation of protein deacetylation (GO:0090312)2.38620078
155pinocytosis (GO:0006907)2.38536328
156positive regulation of gamma-delta T cell activation (GO:0046645)2.37658248
157regulation of translational termination (GO:0006449)2.36805207
158regulation of histone methylation (GO:0031060)2.36772146
159basement membrane organization (GO:0071711)2.36517485
160cytoskeletal anchoring at plasma membrane (GO:0007016)2.36218423
161DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.36171485
162regulation of histone H3-K4 methylation (GO:0051569)2.36058042
163signal complex assembly (GO:0007172)2.35987958
164positive regulation of DNA-dependent DNA replication (GO:2000105)2.35469165
165regulation of ARF protein signal transduction (GO:0032012)2.35177236
166renal system development (GO:0072001)2.34768854
167trophectodermal cell differentiation (GO:0001829)2.34164824
168negative regulation of fatty acid transport (GO:2000192)2.34059281
169cilium or flagellum-dependent cell motility (GO:0001539)2.33037674
170monoubiquitinated protein deubiquitination (GO:0035520)2.32191621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.69900641
2E2F7_22180533_ChIP-Seq_HELA_Human4.36997920
3* MYC_22102868_ChIP-Seq_BL_Human4.00817467
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.32746390
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22659961
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.97295009
7VDR_21846776_ChIP-Seq_THP-1_Human2.74660895
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.72833717
9* KDM2B_26808549_Chip-Seq_DND41_Human2.69661220
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.69268642
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.67037859
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.48335544
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43742719
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.39755000
15* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35998331
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.25487097
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08121517
18* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.08063980
19* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00479697
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98867561
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98158916
22* ELK3_25401928_ChIP-Seq_HUVEC_Human1.93112348
23LXR_22292898_ChIP-Seq_THP-1_Human1.87586699
24* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.87138187
25KDM2B_26808549_Chip-Seq_JURKAT_Human1.86256226
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82662906
27KDM2B_26808549_Chip-Seq_K562_Human1.78625066
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75869318
29* UTX_26944678_Chip-Seq_JUKART_Human1.72032756
30CIITA_25753668_ChIP-Seq_RAJI_Human1.70269220
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.70125921
32* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.68841434
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61522612
34* MAF_26560356_Chip-Seq_TH1_Human1.60954939
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55994411
36* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50705278
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50692671
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49752530
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49037733
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46958443
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43074843
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42965227
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.40456953
44* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40051264
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39867409
46CLOCK_20551151_ChIP-Seq_293T_Human1.38842015
47* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38749581
48* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38007985
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37939536
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35533930
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33054983
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32479779
53* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32313575
54* P68_20966046_ChIP-Seq_HELA_Human1.31906070
55VDR_24763502_ChIP-Seq_THP-1_Human1.31813050
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31610634
57* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30950616
58* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30389316
59CREB1_26743006_Chip-Seq_LNCaP_Human1.30388322
60RACK7_27058665_Chip-Seq_MCF-7_Human1.30125163
61* NCOR1_26117541_ChIP-Seq_K562_Human1.29793208
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.29737909
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27786304
64* ELF1_20517297_ChIP-Seq_JURKAT_Human1.25004929
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24710183
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24119722
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24114250
68MAF_26560356_Chip-Seq_TH2_Human1.21888375
69SPI1_23127762_ChIP-Seq_K562_Human1.21139564
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20427047
71TP53_22127205_ChIP-Seq_IMR90_Human1.19300967
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19255125
73TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.19153362
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18789047
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.16783106
76SCL_19346495_ChIP-Seq_HPC-7_Human1.16465666
77ZNF263_19887448_ChIP-Seq_K562_Human1.16392313
78* ATF3_27146783_Chip-Seq_COLON_Human1.15657527
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15351588
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.14583943
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13657825
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12109460
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10764379
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.10363713
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09307169
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08125162
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07559796
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07305329
89* MYB_26560356_Chip-Seq_TH1_Human1.07149997
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.07020699
91E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06801288
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06353373
93* SMC4_20622854_ChIP-Seq_HELA_Human1.06350386
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05794654
95* RUNX1_27514584_Chip-Seq_MCF-7_Human1.05459304
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04569270
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04094795
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03844743
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.03522159
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03236228
101POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02656727
102* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02199618
103* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00675031
104GATA1_19941826_ChIP-Seq_K562_Human1.00593772
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00115811
106* PHF8_20622854_ChIP-Seq_HELA_Human0.99012530
107* XRN2_22483619_ChIP-Seq_HELA_Human0.98780028
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98656855
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97793322
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.97212952
111* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97185071
112MYC_18555785_ChIP-Seq_MESCs_Mouse0.97060080
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97035999
114KDM5A_27292631_Chip-Seq_BREAST_Human0.96981106
115FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96792618
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96366412
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95235774
118E2F1_20622854_ChIP-Seq_HELA_Human0.95101801
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94676214
120FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94119917
121* MYB_26560356_Chip-Seq_TH2_Human0.93955859
122* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93704169
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.93183429
124* E2F1_21310950_ChIP-Seq_MCF-7_Human0.93167986
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92397503
126BCOR_27268052_Chip-Seq_Bcells_Human0.92095980
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91975996
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91848487
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.91618971
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91584100
131ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91473801
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.88676225
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87390064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.79319175
2MP0005076_abnormal_cell_differentiation3.74859017
3MP0008961_abnormal_basal_metabolism2.93807445
4MP0005451_abnormal_body_composition2.86883558
5MP0003283_abnormal_digestive_organ2.72214470
6MP0000569_abnormal_digit_pigmentation2.69234450
7MP0010030_abnormal_orbit_morphology2.55151613
8MP0009278_abnormal_bone_marrow2.48042097
9MP0003705_abnormal_hypodermis_morpholog2.31601881
10MP0005409_darkened_coat_color2.26272778
11MP0005058_abnormal_lysosome_morphology2.24370261
12MP0003111_abnormal_nucleus_morphology2.23945324
13MP0000678_abnormal_parathyroid_gland2.15848118
14MP0010352_gastrointestinal_tract_polyps2.11731327
15MP0001348_abnormal_lacrimal_gland2.06924081
16MP0005410_abnormal_fertilization2.06214292
17MP0003436_decreased_susceptibility_to1.91957147
18MP0004233_abnormal_muscle_weight1.87940738
19MP0001849_ear_inflammation1.86650309
20MP0003115_abnormal_respiratory_system1.85238124
21MP0002084_abnormal_developmental_patter1.83336189
22MP0004858_abnormal_nervous_system1.82858886
23MP0008260_abnormal_autophagy1.81315930
24MP0001730_embryonic_growth_arrest1.75639501
25MP0003453_abnormal_keratinocyte_physiol1.74927681
26MP0000350_abnormal_cell_proliferation1.73563234
27MP0003077_abnormal_cell_cycle1.73469435
28MP0010307_abnormal_tumor_latency1.73410581
29MP0000537_abnormal_urethra_morphology1.71349548
30MP0002396_abnormal_hematopoietic_system1.68307370
31MP0000733_abnormal_muscle_development1.67687222
32MP0004197_abnormal_fetal_growth/weight/1.67410380
33MP0003300_gastrointestinal_ulcer1.65380853
34MP0002085_abnormal_embryonic_tissue1.64263226
35MP0004947_skin_inflammation1.53190180
36MP0010234_abnormal_vibrissa_follicle1.51920081
37MP0004808_abnormal_hematopoietic_stem1.51904103
38MP0001672_abnormal_embryogenesis/_devel1.51068667
39MP0005380_embryogenesis_phenotype1.51068667
40MP0003984_embryonic_growth_retardation1.50401517
41MP0001697_abnormal_embryo_size1.48731251
42MP0002088_abnormal_embryonic_growth/wei1.46819934
43MP0009333_abnormal_splenocyte_physiolog1.45524207
44MP0003121_genomic_imprinting1.44708953
45MP0005670_abnormal_white_adipose1.43855300
46MP0009840_abnormal_foam_cell1.43352666
47MP0003303_peritoneal_inflammation1.40926200
48MP0003566_abnormal_cell_adhesion1.40589021
49MP0003693_abnormal_embryo_hatching1.40553244
50MP0010094_abnormal_chromosome_stability1.40221268
51MP0003890_abnormal_embryonic-extraembry1.39441477
52MP0008057_abnormal_DNA_replication1.39104251
53MP0008877_abnormal_DNA_methylation1.39010044
54MP0000858_altered_metastatic_potential1.38999630
55MP0002086_abnormal_extraembryonic_tissu1.36134277
56MP0008995_early_reproductive_senescence1.35359575
57MP0000428_abnormal_craniofacial_morphol1.33561184
58MP0003091_abnormal_cell_migration1.33229770
59MP0008438_abnormal_cutaneous_collagen1.32607833
60MP0001929_abnormal_gametogenesis1.29727519
61MP0001293_anophthalmia1.27797396
62MP0000534_abnormal_ureter_morphology1.27610818
63MP0000685_abnormal_immune_system1.26968502
64MP0001873_stomach_inflammation1.23587457
65MP0003122_maternal_imprinting1.23080175
66MP0003119_abnormal_digestive_system1.22177573
67MP0002092_abnormal_eye_morphology1.21574313
68MP0003698_abnormal_male_reproductive1.21152144
69MP0002080_prenatal_lethality1.19592991
70MP0004381_abnormal_hair_follicle1.17229586
71MP0005623_abnormal_meninges_morphology1.15327293
72MP0002089_abnormal_postnatal_growth/wei1.15253835
73MP0005397_hematopoietic_system_phenotyp1.15214337
74MP0001545_abnormal_hematopoietic_system1.15214337
75MP0003861_abnormal_nervous_system1.15193959
76MP0005023_abnormal_wound_healing1.14470560
77MP0004957_abnormal_blastocyst_morpholog1.13817204
78MP0002796_impaired_skin_barrier1.12627790
79MP0000703_abnormal_thymus_morphology1.11945016
80MP0002925_abnormal_cardiovascular_devel1.10842932
81MP0002234_abnormal_pharynx_morphology1.08518741
82MP0009053_abnormal_anal_canal1.08479439
83MP0002282_abnormal_trachea_morphology1.08190748
84MP0002249_abnormal_larynx_morphology1.07726296
85MP0000566_synostosis1.07232968
86MP0004185_abnormal_adipocyte_glucose1.05294446
87MP0005501_abnormal_skin_physiology1.05146928
88MP0009780_abnormal_chondrocyte_physiolo1.04993939
89MP0004264_abnormal_extraembryonic_tissu1.04743502
90MP0003935_abnormal_craniofacial_develop1.03576069
91MP0002210_abnormal_sex_determination1.02680968
92MP0004133_heterotaxia1.00498732
93MP0003942_abnormal_urinary_system0.98741270
94MP0009703_decreased_birth_body0.98583165
95MP0009931_abnormal_skin_appearance0.96433558
96MP0002722_abnormal_immune_system0.96237099
97MP0001915_intracranial_hemorrhage0.96034120
98MP0009672_abnormal_birth_weight0.95890273
99MP0002009_preneoplasia0.95857617
100MP0000003_abnormal_adipose_tissue0.94649842
101MP0002060_abnormal_skin_morphology0.91069000
102MP0005375_adipose_tissue_phenotype0.90876172
103MP0003172_abnormal_lysosome_physiology0.90192191
104MP0010630_abnormal_cardiac_muscle0.89803041
105MP0005621_abnormal_cell_physiology0.89293413
106MP0002429_abnormal_blood_cell0.89145762
107MP0002161_abnormal_fertility/fecundity0.88144209
108MP0002166_altered_tumor_susceptibility0.87807143
109MP0001145_abnormal_male_reproductive0.87686513
110MP0003329_amyloid_beta_deposits0.87163427
111MP0002697_abnormal_eye_size0.86623919
112MP0008770_decreased_survivor_rate0.86179931
113MP0000266_abnormal_heart_morphology0.85908492
114MP0002998_abnormal_bone_remodeling0.85509498
115MP0008007_abnormal_cellular_replicative0.85159397
116MP0000490_abnormal_crypts_of0.85012137
117MP0000313_abnormal_cell_death0.84828565
118MP0000467_abnormal_esophagus_morphology0.84777371
119MP0003123_paternal_imprinting0.84520120
120MP0002932_abnormal_joint_morphology0.84489573
121MP0002970_abnormal_white_adipose0.84297648
122MP0000716_abnormal_immune_system0.82206475
123MP0005666_abnormal_adipose_tissue0.82041178
124MP0002116_abnormal_craniofacial_bone0.81016182
125MP0005257_abnormal_intraocular_pressure0.80295589
126MP0002877_abnormal_melanocyte_morpholog0.79111756
127MP0000462_abnormal_digestive_system0.78377146
128MP0001790_abnormal_immune_system0.77395735
129MP0005387_immune_system_phenotype0.77395735
130MP0005000_abnormal_immune_tolerance0.76910760
131MP0005384_cellular_phenotype0.76711111
132MP0004510_myositis0.75771267
133MP0003763_abnormal_thymus_physiology0.75585575
134MP0002398_abnormal_bone_marrow0.74984802
135MP0001784_abnormal_fluid_regulation0.74062801
136MP0001800_abnormal_humoral_immune0.73865199
137MP0002405_respiratory_system_inflammati0.73694492
138MP0003656_abnormal_erythrocyte_physiolo0.69690716
139MP0001216_abnormal_epidermal_layer0.69646504
140MP0002420_abnormal_adaptive_immunity0.69538238

Predicted human phenotypes

RankGene SetZ-score
1Heterotopia (HP:0002282)3.78494446
2Hyperacusis (HP:0010780)3.56170276
3Obstructive sleep apnea (HP:0002870)3.37325999
4Ependymoma (HP:0002888)3.29339714
5Broad face (HP:0000283)3.14702112
6Abnormality of the fingertips (HP:0001211)3.03310293
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96564040
8Short 4th metacarpal (HP:0010044)2.96564040
9Cerebral aneurysm (HP:0004944)2.95676339
10Abnormality of the astrocytes (HP:0100707)2.82071733
11Astrocytoma (HP:0009592)2.82071733
12Increased nuchal translucency (HP:0010880)2.70998157
13Neoplasm of the heart (HP:0100544)2.58584613
14Abnormality of the lower motor neuron (HP:0002366)2.53520391
15Hand muscle atrophy (HP:0009130)2.51208367
16Cholecystitis (HP:0001082)2.50982054
17Abnormal gallbladder physiology (HP:0012438)2.50982054
18Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.46445215
19Renal duplication (HP:0000075)2.46037916
20Shallow orbits (HP:0000586)2.44900402
21Long eyelashes (HP:0000527)2.43858334
22Elfin facies (HP:0004428)2.43561704
23Deep venous thrombosis (HP:0002625)2.42593717
24Renovascular hypertension (HP:0100817)2.41289121
25Hemorrhage of the eye (HP:0011885)2.39716516
26Upper limb amyotrophy (HP:0009129)2.39528166
27Distal upper limb amyotrophy (HP:0007149)2.39528166
28Macroorchidism (HP:0000053)2.39241620
29Distal lower limb amyotrophy (HP:0008944)2.36691124
30Trigonocephaly (HP:0000243)2.35079169
31Flat acetabular roof (HP:0003180)2.34345135
32Reticulocytosis (HP:0001923)2.32960748
33Asymmetry of the thorax (HP:0001555)2.23775009
34Insomnia (HP:0100785)2.23392892
35Nasal polyposis (HP:0100582)2.23161320
36Abnormality of the 4th metacarpal (HP:0010012)2.13454630
37Pointed chin (HP:0000307)2.12817167
38Anal stenosis (HP:0002025)2.10757522
39Obsessive-compulsive behavior (HP:0000722)2.10400679
40Abnormality of the thoracic spine (HP:0100711)2.10009509
41Pseudobulbar signs (HP:0002200)2.08353749
42Cellulitis (HP:0100658)2.05986157
43Thin bony cortex (HP:0002753)2.03882298
44Prominent nose (HP:0000448)2.03793116
45Aortic aneurysm (HP:0004942)2.03582407
46Bowel incontinence (HP:0002607)1.98411928
47Glioma (HP:0009733)1.96644151
48Biconcave vertebral bodies (HP:0004586)1.96504926
49Centrally nucleated skeletal muscle fibers (HP:0003687)1.95552558
50Dislocated radial head (HP:0003083)1.95245277
51Broad palm (HP:0001169)1.94753766
52Urethral obstruction (HP:0000796)1.94303969
53Overriding aorta (HP:0002623)1.93944577
54Degeneration of anterior horn cells (HP:0002398)1.93199302
55Abnormality of the anterior horn cell (HP:0006802)1.93199302
56Aneurysm (HP:0002617)1.92756450
57Achilles tendon contracture (HP:0001771)1.92635216
58Segmental peripheral demyelination/remyelination (HP:0003481)1.92131690
59Truncus arteriosus (HP:0001660)1.91346349
60Megalocornea (HP:0000485)1.91097543
61Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.90580737
62Premature skin wrinkling (HP:0100678)1.90370230
63Genu recurvatum (HP:0002816)1.90107751
64Skin tags (HP:0010609)1.90007236
65Metaphyseal cupping (HP:0003021)1.89825570
66Spinal muscular atrophy (HP:0007269)1.89439768
67Broad thumb (HP:0011304)1.87588440
68Narrow palate (HP:0000189)1.86595136
69Increased IgE level (HP:0003212)1.85874654
70Bowel diverticulosis (HP:0005222)1.85370072
71Leiomyosarcoma (HP:0100243)1.83954756
72Uterine leiomyosarcoma (HP:0002891)1.83954756
73Patellar dislocation (HP:0002999)1.83705168
74Thin ribs (HP:0000883)1.83451886
75Gastrointestinal carcinoma (HP:0002672)1.82284584
76Malignant gastrointestinal tract tumors (HP:0006749)1.82284584
77Abnormal large intestine physiology (HP:0012700)1.81746322
78Vertebral compression fractures (HP:0002953)1.81357246
79Selective tooth agenesis (HP:0001592)1.81182170
80Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81050999
81Abnormality of the nasal mucosa (HP:0000433)1.80115963
82Neoplasm of the oral cavity (HP:0100649)1.79149428
83Abnormality of the radial head (HP:0003995)1.78887534
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.78504213
85Colitis (HP:0002583)1.78037358
86Limited elbow extension (HP:0001377)1.77822075
87Increased connective tissue (HP:0009025)1.77736706
88High pitched voice (HP:0001620)1.77557078
89Increased density of long bones (HP:0006392)1.77463604
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77380146
91Abnormality of the epiphyses of the hand (HP:0005924)1.77265507
92Abnormality of the Achilles tendon (HP:0005109)1.76887263
93Premature rupture of membranes (HP:0001788)1.76742972
94Ulnar bowing (HP:0003031)1.76641945
95Ectopic kidney (HP:0000086)1.76380121
96Lower limb amyotrophy (HP:0007210)1.75351223
97Truncal obesity (HP:0001956)1.75091519
98Seborrheic dermatitis (HP:0001051)1.74568488
99Hypertensive crisis (HP:0100735)1.74233371
100Mitral regurgitation (HP:0001653)1.74132319
101Easy fatigability (HP:0003388)1.73905844
102Hallux valgus (HP:0001822)1.73429261
103Emphysema (HP:0002097)1.73052972
104Skull defect (HP:0001362)1.72771755
105Dysmetric saccades (HP:0000641)1.71738492
106Male infertility (HP:0003251)1.71349697
107Ankyloglossia (HP:0010296)1.71170016
108Mitral valve prolapse (HP:0001634)1.70903630
109Long palpebral fissure (HP:0000637)1.70850683
110Amyotrophic lateral sclerosis (HP:0007354)1.69843325
111Syringomyelia (HP:0003396)1.69819804
112Spinal cord lesions (HP:0100561)1.69819804
113Abnormality of the labia minora (HP:0012880)1.69604513
114Proximal placement of thumb (HP:0009623)1.69407987
115Deviation of the thumb (HP:0009603)1.68984336
116Deviation of the hallux (HP:0010051)1.68845738
117J-shaped sella turcica (HP:0002680)1.68798933
118Cervical subluxation (HP:0003308)1.68696574
119Abnormal number of incisors (HP:0011064)1.67937445
120Thoracic kyphosis (HP:0002942)1.67447392
121Annular pancreas (HP:0001734)1.64999269
122Disproportionate tall stature (HP:0001519)1.64592180
123Broad phalanges of the hand (HP:0009768)1.64235572
124Bicuspid aortic valve (HP:0001647)1.64227545
125Deep palmar crease (HP:0006191)1.63942223
126Long toe (HP:0010511)1.63606418
127Sandal gap (HP:0001852)1.62940981
128Transitional cell carcinoma of the bladder (HP:0006740)1.62912686
129Enlarged penis (HP:0000040)1.62609794
130Sacral dimple (HP:0000960)1.60868582
131Arnold-Chiari malformation (HP:0002308)1.60753852
132Abnormality of the columella (HP:0009929)1.60638455
133Bronchomalacia (HP:0002780)1.60497453
134Protrusio acetabuli (HP:0003179)1.60195308
135Flat cornea (HP:0007720)1.59105465
136Abnormality of reticulocytes (HP:0004312)1.59006059
137Abnormality of oral frenula (HP:0000190)1.58885033
138Fragile skin (HP:0001030)1.58708451
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.58463747
140Polygenic inheritance (HP:0010982)1.58313127
141Volvulus (HP:0002580)1.57616320
142Stridor (HP:0010307)1.57517224
143Overlapping toe (HP:0001845)1.57464605
144Preauricular skin tag (HP:0000384)1.57011444
145Ankle contracture (HP:0006466)1.56784128
146Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.56555212
147Abnormality of chromosome segregation (HP:0002916)1.56466980
148Peripheral hypomyelination (HP:0007182)1.56357810
149Rib fusion (HP:0000902)1.56289978
150Lymphangioma (HP:0100764)1.55962118
151Slow saccadic eye movements (HP:0000514)1.55919223
152Oligodactyly (HP:0012165)1.55740629
153Gastrointestinal stroma tumor (HP:0100723)1.55572986
154Germ cell neoplasia (HP:0100728)1.55347585
155Supranuclear gaze palsy (HP:0000605)1.55194547
156Spina bifida occulta (HP:0003298)1.55095811
157Cutis marmorata (HP:0000965)1.54712667
158Gastrointestinal inflammation (HP:0004386)1.54429684
159Bladder diverticulum (HP:0000015)1.54103007
160Polycythemia (HP:0001901)1.53108231
161Persistence of primary teeth (HP:0006335)1.53046122
162Self-mutilation (HP:0000742)1.52969641
163Advanced eruption of teeth (HP:0006288)1.52184633
164Neoplasm of striated muscle (HP:0009728)1.51927857
165Atelectasis (HP:0100750)1.51712738
166Hypercortisolism (HP:0001578)1.51450888
167Eczematoid dermatitis (HP:0000976)1.51210212
168Hammertoe (HP:0001765)1.50646295
169Neuronal loss in central nervous system (HP:0002529)1.50267361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.50010289
2EEF2K3.80485493
3ICK3.67716309
4PRPF4B3.55742234
5SMG13.48181600
6MAP3K103.30074750
7SIK33.01643294
8TRIB32.99519054
9ERN12.45664052
10PRKD32.29428915
11NEK22.20206295
12BRD42.13700675
13KSR12.05033783
14PKN21.95857453
15IRAK31.94461174
16CAMK1G1.85606528
17SIK11.80144613
18TYRO31.78143626
19MAP3K131.64831086
20* MTOR1.52612459
21CAMK1D1.51393985
22CDC71.50353325
23SIK21.49614540
24TAOK11.49429303
25EPHB21.48521030
26MAP4K11.43836875
27LATS11.41924654
28NTRK21.37609965
29RIPK41.37505766
30PDGFRA1.35590498
31RIPK11.33595753
32PTK61.19369634
33ALK1.17198698
34TESK11.15161069
35CDK41.08272146
36STK101.07545112
37PAK41.02841788
38DMPK1.02395316
39MAP2K31.02277786
40TAOK21.01449352
41FGFR30.99821739
42NME20.98428691
43TTN0.97944220
44FGFR40.96887703
45LATS20.96582035
46MAPK110.96457084
47MAP3K140.95734301
48STK30.91228801
49BMX0.90153685
50NTRK10.89752776
51DYRK1B0.89240716
52CDK60.87685218
53CHEK10.86990066
54STK380.86900594
55MST1R0.86192862
56ERBB20.85582741
57MAP3K10.83536229
58NEK10.82703663
59MARK20.82281790
60EPHA20.82034870
61PAK60.81284119
62MAP3K70.80863257
63UHMK10.80357955
64FGFR10.79127132
65PDK40.78346232
66PDK30.78346232
67ATR0.78167140
68TTK0.77975631
69PASK0.75403205
70CHUK0.73153128
71PTK20.73066241
72MAPKAPK30.71921864
73PDPK10.70670247
74TYK20.68309686
75PAK20.68265172
76CDC42BPA0.66516447
77MAP3K90.65828930
78CDK70.65823400
79KSR20.64968712
80RPS6KA20.64956566
81PDGFRB0.64680210
82PNCK0.64371189
83CDK20.63199541
84IRAK40.63045264
85RPS6KL10.59392983
86RPS6KC10.59392983
87FGFR20.57299263
88MELK0.56691519
89CDK90.56483071
90CHEK20.55785701
91PRKD20.54528458
92RPS6KB20.53276155
93BRAF0.53250711
94IRAK20.52897153
95GRK60.52662733
96RET0.51903474
97ARAF0.51515270
98TESK20.50689297
99MAP3K30.49973000
100RPS6KA10.49733173
101WNK30.49544101
102WNK10.49127012
103MAP2K20.49029654
104PDK10.48039038
105AKT20.47798319
106ATM0.47745552
107CAMKK10.47415664
108TBK10.47062772
109MAP3K80.46814709
110ZAP700.45942515
111BUB10.45669786
112EPHB10.45655213
113DDR20.45566007
114LRRK20.44572357
115BTK0.44233718
116MAPK100.43858720
117TNK20.43761558
118CDK10.43710288
119HCK0.43464016
120MAPK120.42581669
121CLK10.42360829
122MAP3K110.42252894
123HIPK20.40846634
124SGK30.39321701
125PRKCH0.39090842
126MAPK10.38548024
127RPS6KA60.38312366
128MAPK140.37903746
129PRKAA10.37869883
130GSK3B0.37797219
131JAK30.37379420
132BRSK10.36880925
133PLK10.36380299
134CSNK1D0.35597271
135MAP3K20.34064832
136MAPKAPK20.33121082
137MAP3K60.31873047
138MAPK80.30993992

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.46195215
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29319950
3Chronic myeloid leukemia_Homo sapiens_hsa052202.06526760
4Other glycan degradation_Homo sapiens_hsa005112.03955166
5Lysine degradation_Homo sapiens_hsa003102.01341400
6Dorso-ventral axis formation_Homo sapiens_hsa043201.91210546
7mRNA surveillance pathway_Homo sapiens_hsa030151.75927820
8mTOR signaling pathway_Homo sapiens_hsa041501.74272738
9Basal cell carcinoma_Homo sapiens_hsa052171.72558159
10Thyroid hormone signaling pathway_Homo sapiens_hsa049191.57555266
11MicroRNAs in cancer_Homo sapiens_hsa052061.54868412
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46868021
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46102651
14Colorectal cancer_Homo sapiens_hsa052101.38819401
15Neurotrophin signaling pathway_Homo sapiens_hsa047221.38576873
16Cell cycle_Homo sapiens_hsa041101.38434357
17Non-small cell lung cancer_Homo sapiens_hsa052231.37575776
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.37254264
19Endometrial cancer_Homo sapiens_hsa052131.32658886
20Hippo signaling pathway_Homo sapiens_hsa043901.30730242
21Prion diseases_Homo sapiens_hsa050201.29367670
22Pancreatic cancer_Homo sapiens_hsa052121.29328379
23Bladder cancer_Homo sapiens_hsa052191.28271161
24VEGF signaling pathway_Homo sapiens_hsa043701.27413332
25Adherens junction_Homo sapiens_hsa045201.26093537
26Hedgehog signaling pathway_Homo sapiens_hsa043401.24939271
27B cell receptor signaling pathway_Homo sapiens_hsa046621.24141146
28Acute myeloid leukemia_Homo sapiens_hsa052211.23588230
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23373499
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21761671
31Glioma_Homo sapiens_hsa052141.20757792
32RNA transport_Homo sapiens_hsa030131.20294205
33Proteoglycans in cancer_Homo sapiens_hsa052051.20151118
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.19467575
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19350798
36HTLV-I infection_Homo sapiens_hsa051661.18677281
37Renal cell carcinoma_Homo sapiens_hsa052111.16742281
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16610858
39Small cell lung cancer_Homo sapiens_hsa052221.16155199
40Type II diabetes mellitus_Homo sapiens_hsa049301.14701142
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13512634
42Estrogen signaling pathway_Homo sapiens_hsa049151.10687061
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09507424
44T cell receptor signaling pathway_Homo sapiens_hsa046601.09272387
45Oocyte meiosis_Homo sapiens_hsa041141.07193938
46Fructose and mannose metabolism_Homo sapiens_hsa000511.07135505
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06821544
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03406946
49Spliceosome_Homo sapiens_hsa030400.99921780
50Pentose phosphate pathway_Homo sapiens_hsa000300.99355066
51GnRH signaling pathway_Homo sapiens_hsa049120.98912552
52ErbB signaling pathway_Homo sapiens_hsa040120.98439036
53Viral myocarditis_Homo sapiens_hsa054160.95383231
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.93854856
55Prolactin signaling pathway_Homo sapiens_hsa049170.93112766
56Insulin resistance_Homo sapiens_hsa049310.92714124
57Hepatitis B_Homo sapiens_hsa051610.92459314
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92228151
59Insulin signaling pathway_Homo sapiens_hsa049100.91485676
60Glucagon signaling pathway_Homo sapiens_hsa049220.90764833
61Hepatitis C_Homo sapiens_hsa051600.90692115
62Long-term potentiation_Homo sapiens_hsa047200.90590276
63Wnt signaling pathway_Homo sapiens_hsa043100.90015127
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88964418
65Biosynthesis of amino acids_Homo sapiens_hsa012300.88874217
66AMPK signaling pathway_Homo sapiens_hsa041520.88790557
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87846088
68Focal adhesion_Homo sapiens_hsa045100.86575709
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86505277
70Viral carcinogenesis_Homo sapiens_hsa052030.86281290
71TNF signaling pathway_Homo sapiens_hsa046680.83150570
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.82100176
73Pathways in cancer_Homo sapiens_hsa052000.81352272
74Choline metabolism in cancer_Homo sapiens_hsa052310.80651734
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79569565
76Endocytosis_Homo sapiens_hsa041440.79394965
77DNA replication_Homo sapiens_hsa030300.79364811
78Leishmaniasis_Homo sapiens_hsa051400.78225967
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78180271
80Prostate cancer_Homo sapiens_hsa052150.76280623
81Osteoclast differentiation_Homo sapiens_hsa043800.76065060
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75520264
83HIF-1 signaling pathway_Homo sapiens_hsa040660.74796799
84Toxoplasmosis_Homo sapiens_hsa051450.74706648
85Shigellosis_Homo sapiens_hsa051310.74105564
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.71537615
87Herpes simplex infection_Homo sapiens_hsa051680.70681981
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70481908
89Base excision repair_Homo sapiens_hsa034100.70374682
90MAPK signaling pathway_Homo sapiens_hsa040100.68900302
91Thyroid cancer_Homo sapiens_hsa052160.67382452
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.67175018
93Axon guidance_Homo sapiens_hsa043600.66834879
94Apoptosis_Homo sapiens_hsa042100.66820553
95Amoebiasis_Homo sapiens_hsa051460.65716087
96Primary immunodeficiency_Homo sapiens_hsa053400.64857916
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64717308
98Inositol phosphate metabolism_Homo sapiens_hsa005620.64568278
99TGF-beta signaling pathway_Homo sapiens_hsa043500.64298757
100FoxO signaling pathway_Homo sapiens_hsa040680.64265453
101p53 signaling pathway_Homo sapiens_hsa041150.64117535
102Antigen processing and presentation_Homo sapiens_hsa046120.63083649
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62095386
104Rap1 signaling pathway_Homo sapiens_hsa040150.61273954
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.60693641
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60353339
107Melanogenesis_Homo sapiens_hsa049160.59778775
108Galactose metabolism_Homo sapiens_hsa000520.59006913
109Chemokine signaling pathway_Homo sapiens_hsa040620.58775419
110Epstein-Barr virus infection_Homo sapiens_hsa051690.58355762
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57261489
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57249561
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56248259
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.55689786
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55435226
116Influenza A_Homo sapiens_hsa051640.54681590
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54498717
118Gap junction_Homo sapiens_hsa045400.54160766
119Platelet activation_Homo sapiens_hsa046110.52340373
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52115491
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51642760
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50016907
123Measles_Homo sapiens_hsa051620.49675817
124Tuberculosis_Homo sapiens_hsa051520.46678668
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45701616
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45545867

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