ATXN3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene may be a pseudogene (PMID:11450850). This gene is similar to the multi-exon gene which encodes ataxin 3 and contains a coding region which could encode a protein similar to ataxin 3. Mutations in the gene encoding ataxin 3 are associated with Machado-Joseph disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.55811207
2fusion of sperm to egg plasma membrane (GO:0007342)8.66784978
3chromosome condensation (GO:0030261)8.19231759
4microtubule depolymerization (GO:0007019)8.00870304
5DNA packaging (GO:0006323)7.94692446
6sperm capacitation (GO:0048240)7.40159168
7binding of sperm to zona pellucida (GO:0007339)7.37322953
8sperm-egg recognition (GO:0035036)7.30611182
9spermatid development (GO:0007286)7.13446231
10nuclear pore complex assembly (GO:0051292)7.11761658
11multicellular organism reproduction (GO:0032504)6.71984263
12plasma membrane fusion (GO:0045026)6.51666752
13spermatid nucleus differentiation (GO:0007289)6.33565259
14rRNA methylation (GO:0031167)6.26695971
15microtubule polymerization or depolymerization (GO:0031109)6.26412841
16cell-cell recognition (GO:0009988)6.09268708
17response to pheromone (GO:0019236)5.99946879
18reproduction (GO:0000003)5.98651626
19nuclear pore organization (GO:0006999)5.93943781
20pore complex assembly (GO:0046931)5.52476334
21protein-DNA complex disassembly (GO:0032986)5.44500033
22nucleosome disassembly (GO:0006337)5.44500033
23single strand break repair (GO:0000012)5.41410564
24motile cilium assembly (GO:0044458)5.34277580
25centriole assembly (GO:0098534)5.18437964
26male meiosis (GO:0007140)5.13125893
27axonemal dynein complex assembly (GO:0070286)5.13111580
28rRNA modification (GO:0000154)5.12485930
29centriole replication (GO:0007099)5.10591751
30protein targeting to Golgi (GO:0000042)5.09646113
31calcium ion-dependent exocytosis (GO:0017156)5.05112294
32phosphatidylethanolamine biosynthetic process (GO:0006646)4.99648680
33negative regulation of inclusion body assembly (GO:0090084)4.94714137
34establishment of protein localization to Golgi (GO:0072600)4.88446577
35synapsis (GO:0007129)4.88336740
36sexual reproduction (GO:0019953)4.86678135
37regulation of centriole replication (GO:0046599)4.86621918
38spermatogenesis (GO:0007283)4.75062921
39male gamete generation (GO:0048232)4.74458974
40detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.73558708
41regulation of phosphoprotein phosphatase activity (GO:0043666)4.64648611
42retrograde transport, vesicle recycling within Golgi (GO:0000301)4.63587411
43cilium or flagellum-dependent cell motility (GO:0001539)4.58495324
44phosphatidylethanolamine metabolic process (GO:0046337)4.55941600
45single fertilization (GO:0007338)4.47626697
46regulation of histone H3-K27 methylation (GO:0061085)4.37364214
47gamete generation (GO:0007276)4.33977952
48DNA methylation involved in gamete generation (GO:0043046)4.22402045
49organic cation transport (GO:0015695)4.12297438
50germ cell development (GO:0007281)4.09568037
51histone H3-K9 demethylation (GO:0033169)4.08413886
52nucleus organization (GO:0006997)4.01159148
53coenzyme catabolic process (GO:0009109)3.93754524
54estrogen biosynthetic process (GO:0006703)3.92493239
55diterpenoid biosynthetic process (GO:0016102)3.87541299
56resolution of meiotic recombination intermediates (GO:0000712)3.86373004
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.81201430
58protein polyglutamylation (GO:0018095)3.79333774
59cellular ketone body metabolic process (GO:0046950)3.72867604
60fertilization (GO:0009566)3.70854412
61polyamine biosynthetic process (GO:0006596)3.70017820
62protein localization to Golgi apparatus (GO:0034067)3.69755198
63DNA conformation change (GO:0071103)3.67368991
64microtubule severing (GO:0051013)3.63382511
65regulation of Rab GTPase activity (GO:0032313)3.58678532
66positive regulation of Rab GTPase activity (GO:0032851)3.58678532
67negative regulation of histone methylation (GO:0031061)3.58163438
68chromatin silencing (GO:0006342)3.52321259
69histone exchange (GO:0043486)3.49911726
70multicellular organismal reproductive process (GO:0048609)3.47149474
71regulation of inclusion body assembly (GO:0090083)3.35034752
72chromosome organization involved in meiosis (GO:0070192)3.33203931
73potassium ion export (GO:0071435)3.31152974
74regulation of translational fidelity (GO:0006450)3.28501396
75ketone body metabolic process (GO:1902224)3.25497057
76face development (GO:0060324)3.24413833
77male meiosis I (GO:0007141)3.17834894
78regulation of cilium movement (GO:0003352)3.17292771
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16218270
80peptidyl-threonine dephosphorylation (GO:0035970)3.14691912
81response to vitamin A (GO:0033189)3.11810276
82ribosome assembly (GO:0042255)3.08060750
83protein depolymerization (GO:0051261)3.07646353
84regulation of histone H3-K4 methylation (GO:0051569)3.07226179
85epithelial cilium movement (GO:0003351)3.05785634
86regulation of transcription involved in cell fate commitment (GO:0060850)3.05607975
87mitotic nuclear envelope disassembly (GO:0007077)3.03222729
88terpenoid biosynthetic process (GO:0016114)2.98899108
89intra-S DNA damage checkpoint (GO:0031573)2.93996810
90regulation of histone H3-K9 methylation (GO:0051570)2.93715891
91detection of chemical stimulus involved in sensory perception (GO:0050907)2.92349318
92membrane disassembly (GO:0030397)2.90010052
93nuclear envelope disassembly (GO:0051081)2.90010052
94DNA replication checkpoint (GO:0000076)2.89786109
95definitive hemopoiesis (GO:0060216)2.84036535
96meiotic nuclear division (GO:0007126)2.83562478
97ventricular system development (GO:0021591)2.83451545
98glycerol ether metabolic process (GO:0006662)2.80123118
99seminiferous tubule development (GO:0072520)2.77815313
100acrosome reaction (GO:0007340)10.0883939

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74927692
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.69522076
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.63137499
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.60031384
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38750770
6GATA1_19941826_ChIP-Seq_K562_Human2.79684041
7GATA1_22025678_ChIP-Seq_K562_Human2.76044252
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.47591403
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31540839
10CDX2_21074721_ChIP-Seq_CACO-2_Mouse2.19052605
11RAC3_21632823_ChIP-Seq_H3396_Human2.15084876
12HNFA_21074721_ChIP-Seq_CACO-2_Human2.13577560
13NCOR1_26117541_ChIP-Seq_K562_Human2.12561282
14FUS_26573619_Chip-Seq_HEK293_Human2.10477790
15ER_23166858_ChIP-Seq_MCF-7_Human2.06622758
16PHF8_20622853_ChIP-Seq_HELA_Human2.04522429
17RBPJ_21746931_ChIP-Seq_IB4_Human2.03485451
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99750630
19GATA6_21074721_ChIP-Seq_CACO-2_Human1.99268728
20NFYB_21822215_ChIP-Seq_K562_Human1.98504011
21CBX2_22325352_ChIP-Seq_293T-Rex_Human1.98154084
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.97837934
23GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.97020499
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.94967189
25CBP_20019798_ChIP-Seq_JUKART_Human1.93880694
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.93880694
27GATA2_19941826_ChIP-Seq_K562_Human1.92486820
28NANOG_20526341_ChIP-Seq_ESCs_Human1.91275216
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90048923
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.89803106
31ETV1_20927104_ChIP-Seq_GIST48_Human1.89049281
32TBL1_22424771_ChIP-Seq_293T_Human1.85681300
33ERA_21632823_ChIP-Seq_H3396_Human1.82479851
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79458805
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79458805
36SPI1_23127762_ChIP-Seq_K562_Human1.77924140
37NFYA_21822215_ChIP-Seq_K562_Human1.68442084
38CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.67773604
39AR_21572438_ChIP-Seq_LNCaP_Human1.67645824
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66278077
41ERG_20517297_ChIP-Seq_VCAP_Human1.62192239
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.61091980
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.60536296
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.60166257
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58973589
46E2F1_20622854_ChIP-Seq_HELA_Human1.58281348
47PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.55788956
48VDR_22108803_ChIP-Seq_LS180_Human1.50811323
49EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.48797714
50CTCF_20526341_ChIP-Seq_ESCs_Human1.48419714
51* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47707233
52PHF8_20622854_ChIP-Seq_HELA_Human1.46257707
53MYC_19829295_ChIP-Seq_ESCs_Human1.44625066
54SMC4_20622854_ChIP-Seq_HELA_Human1.43747574
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43699470
56BCL6_27268052_Chip-Seq_Bcells_Human1.39925319
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.39873095
58* P300_27268052_Chip-Seq_Bcells_Human1.39789033
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35624247
60BCOR_27268052_Chip-Seq_Bcells_Human1.35406626
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34242621
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31484756
63CTCF_27219007_Chip-Seq_Bcells_Human1.31447058
64OCT4_20526341_ChIP-Seq_ESCs_Human1.31193222
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.29267636
66P68_20966046_ChIP-Seq_HELA_Human1.26131043
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26075274
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26060993
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25802532
70OCT1_27270436_Chip-Seq_PROSTATE_Human1.25625236
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25166655
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24743661
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24458155
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.24353178
75SALL4_22934838_ChIP-ChIP_CD34+_Human1.15509863
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12375851
77TAF2_19829295_ChIP-Seq_ESCs_Human1.12035476
78P53_21459846_ChIP-Seq_SAOS-2_Human1.11272799
79IGF1R_20145208_ChIP-Seq_DFB_Human1.10496658
80SPI1_20517297_ChIP-Seq_HL60_Human1.07652814
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06263269
82HOXB7_26014856_ChIP-Seq_BT474_Human1.04995265
83EZH2_22144423_ChIP-Seq_EOC_Human1.04097136
84SOX2_22085726_ChIP-Seq_NPCs_Mouse1.03806908
85* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03288495
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.01573506
87P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.00386175
88SA1_27219007_Chip-Seq_Bcells_Human0.99414590
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98655257
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98622689
91CTCF_21964334_Chip-Seq_Bcells_Human0.97828597
92GATA3_26560356_Chip-Seq_TH1_Human0.96552891
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.96502102
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96335275
95MYB_26560356_Chip-Seq_TH1_Human0.95330306
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95187391
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94868816
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.93938627
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93014778
100KDM5A_27292631_Chip-Seq_BREAST_Human0.90252274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation4.53737333
2MP0003698_abnormal_male_reproductive4.20369507
3MP0001929_abnormal_gametogenesis4.07857626
4MP0000678_abnormal_parathyroid_gland3.64186062
5MP0005451_abnormal_body_composition3.00556986
6MP0008995_early_reproductive_senescence2.83975052
7MP0002132_abnormal_respiratory_system2.73231590
8MP0003718_maternal_effect2.59079182
9MP0005377_hearing/vestibular/ear_phenot2.45527191
10MP0003878_abnormal_ear_physiology2.45527191
11MP0004957_abnormal_blastocyst_morpholog2.40660955
12MP0002161_abnormal_fertility/fecundity2.35881797
13MP0002210_abnormal_sex_determination2.34917211
14MP0001348_abnormal_lacrimal_gland2.24319419
15MP0003693_abnormal_embryo_hatching2.09354384
16MP0005410_abnormal_fertilization10.5642010
17MP0008057_abnormal_DNA_replication1.99038733
18MP0005670_abnormal_white_adipose1.87008663
19MP0001145_abnormal_male_reproductive1.80470157
20MP0008058_abnormal_DNA_repair1.73520483
21MP0000653_abnormal_sex_gland1.69709229
22MP0003077_abnormal_cell_cycle1.64418303
23MP0003646_muscle_fatigue1.62457151
24MP0002249_abnormal_larynx_morphology1.61791019
25MP0004147_increased_porphyrin_level1.56714692
26MP0010094_abnormal_chromosome_stability1.49824315
27MP0004084_abnormal_cardiac_muscle1.45877003
28MP0005083_abnormal_biliary_tract1.43885820
29MP0010307_abnormal_tumor_latency1.41901888
30MP0005647_abnormal_sex_gland1.39555137
31MP0008932_abnormal_embryonic_tissue1.33759425
32MP0001661_extended_life_span1.22830300
33MP0005379_endocrine/exocrine_gland_phen1.20935623
34MP0008004_abnormal_stomach_pH1.20105377
35MP0009115_abnormal_fat_cell1.19996839
36MP0008007_abnormal_cellular_replicative1.19972894
37MP0003111_abnormal_nucleus_morphology1.18388777
38MP0004233_abnormal_muscle_weight1.18222022
39MP0004036_abnormal_muscle_relaxation1.17342755
40MP0005395_other_phenotype1.04439590
41MP0003315_abnormal_perineum_morphology1.02663519
42MP0003959_abnormal_lean_body1.00794668
43MP0002160_abnormal_reproductive_system1.00651564
44MP0005636_abnormal_mineral_homeostasis0.99383094
45MP0004085_abnormal_heartbeat0.98474278
46MP0008877_abnormal_DNA_methylation0.97111140
47MP0003786_premature_aging0.96320988
48MP0003656_abnormal_erythrocyte_physiolo0.94960058
49MP0005397_hematopoietic_system_phenotyp0.91279599
50MP0001545_abnormal_hematopoietic_system0.91279599
51MP0000681_abnormal_thyroid_gland0.89430648
52MP0003936_abnormal_reproductive_system0.88749082
53MP0001919_abnormal_reproductive_system0.86866708
54MP0002282_abnormal_trachea_morphology0.84948723
55MP0003385_abnormal_body_wall0.84402913
56MP0005253_abnormal_eye_physiology0.84234545
57MP0006036_abnormal_mitochondrial_physio0.83509772
58MP0003699_abnormal_female_reproductive0.82150443
59MP0000313_abnormal_cell_death0.80428951
60MP0002269_muscular_atrophy0.79860881
61MP0005389_reproductive_system_phenotype0.78378531
62MP0001764_abnormal_homeostasis0.77478848
63MP0002080_prenatal_lethality0.72592597
64MP0001765_abnormal_ion_homeostasis0.69852949
65MP0008775_abnormal_heart_ventricle0.69572834
66MP0002127_abnormal_cardiovascular_syste0.68556036
67MP0002234_abnormal_pharynx_morphology0.68172343
68MP0003045_fibrosis0.68114341
69MP0005408_hypopigmentation0.64064621
70MP0003950_abnormal_plasma_membrane0.63767873
71MP0004145_abnormal_muscle_electrophysio0.63667065
72MP0000703_abnormal_thymus_morphology0.62911570
73MP0006035_abnormal_mitochondrial_morpho0.62247892
74MP0002086_abnormal_extraembryonic_tissu0.60139464
75MP0003879_abnormal_hair_cell0.57549605
76MP0005666_abnormal_adipose_tissue0.56193592
77MP0002138_abnormal_hepatobiliary_system0.55835697
78MP0008770_decreased_survivor_rate0.55650386
79MP0001730_embryonic_growth_arrest0.55385113
80MP0000350_abnormal_cell_proliferation0.54062768
81MP0001672_abnormal_embryogenesis/_devel0.53674774
82MP0005380_embryogenesis_phenotype0.53674774
83MP0004782_abnormal_surfactant_physiolog0.53271066
84MP0006276_abnormal_autonomic_nervous0.53141625
85MP0005535_abnormal_body_temperature0.52961478
86MP0001697_abnormal_embryo_size0.50896173
87MP0001727_abnormal_embryo_implantation0.49986195
88MP0001119_abnormal_female_reproductive0.49919153
89MP0002638_abnormal_pupillary_reflex0.48846926
90MP0002085_abnormal_embryonic_tissue0.47668208
91MP0004134_abnormal_chest_morphology0.47187982
92MP0005167_abnormal_blood-brain_barrier0.45727860
93MP0000609_abnormal_liver_physiology0.43948253
94MP0005334_abnormal_fat_pad0.43944119
95MP0002229_neurodegeneration0.42893418
96MP0002084_abnormal_developmental_patter0.41955922
97MP0005310_abnormal_salivary_gland0.41854934
98MP0002398_abnormal_bone_marrow0.41721818
99MP0004808_abnormal_hematopoietic_stem0.40904064
100MP0002722_abnormal_immune_system0.39409820

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.00151345
2Absent/shortened dynein arms (HP:0200106)5.00151345
3Severe visual impairment (HP:0001141)4.98016362
4Truncus arteriosus (HP:0001660)4.79316424
5Resting tremor (HP:0002322)4.56572829
6Upper limb muscle weakness (HP:0003484)4.08835862
7Abnormal ciliary motility (HP:0012262)3.99633721
8Abnormal gallbladder physiology (HP:0012438)3.93574992
9Cholecystitis (HP:0001082)3.93574992
10Hyperthyroidism (HP:0000836)3.88931398
11Abnormal respiratory motile cilium physiology (HP:0012261)3.85214551
12Aplasia/Hypoplasia of the earlobes (HP:0009906)3.81770036
13Male infertility (HP:0003251)3.80998585
14Bowel incontinence (HP:0002607)3.77233462
15Infertility (HP:0000789)3.76394792
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.57082618
17Polycythemia (HP:0001901)3.56794997
18Abnormal large intestine physiology (HP:0012700)3.49565484
19Ankyloglossia (HP:0010296)3.41501428
20Abnormal respiratory epithelium morphology (HP:0012253)3.37733095
21Abnormal respiratory motile cilium morphology (HP:0005938)3.37733095
22Reticulocytosis (HP:0001923)3.36239140
23Postural instability (HP:0002172)3.35895859
24Attenuation of retinal blood vessels (HP:0007843)3.34790530
25Tubulointerstitial nephritis (HP:0001970)3.34656200
26Bony spicule pigmentary retinopathy (HP:0007737)3.26614789
27Nasal polyposis (HP:0100582)3.25565555
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.22867306
29Bell-shaped thorax (HP:0001591)3.01549640
30Hypoparathyroidism (HP:0000829)2.92510451
31Seborrheic dermatitis (HP:0001051)2.86499720
32Peripheral hypomyelination (HP:0007182)2.80261357
33Atelectasis (HP:0100750)2.73980874
34Abnormal rod and cone electroretinograms (HP:0008323)2.70175123
35Acute myeloid leukemia (HP:0004808)2.68212214
36Hyperkalemia (HP:0002153)2.65624966
37Sandal gap (HP:0001852)2.62964982
38Colitis (HP:0002583)2.57002549
39Abnormality of the nasal mucosa (HP:0000433)2.55204122
40Hypertensive crisis (HP:0100735)2.52434982
41Abnormality of macular pigmentation (HP:0008002)2.50084654
42Abnormality of cochlea (HP:0000375)2.49889238
43Abnormality of reticulocytes (HP:0004312)2.48974376
44Poikilocytosis (HP:0004447)2.38036624
45Chronic hepatic failure (HP:0100626)2.35713563
46Rhabdomyolysis (HP:0003201)2.32432752
47Facial shape deformation (HP:0011334)2.31794745
48Potter facies (HP:0002009)2.31794745
49Abnormality of DNA repair (HP:0003254)2.29654276
50Abnormality of oral frenula (HP:0000190)2.29538073
51Azoospermia (HP:0000027)2.26355522
52Impulsivity (HP:0100710)2.26136456
53Ileus (HP:0002595)2.26017791
54Abnormal spermatogenesis (HP:0008669)2.25139979
55Unilateral renal agenesis (HP:0000122)2.23710804
56Self-mutilation (HP:0000742)2.23426331
57Tinnitus (HP:0000360)2.21904082
58Aplasia/Hypoplasia of the thymus (HP:0010515)2.19665979
59Cholelithiasis (HP:0001081)2.19343671
60Obsessive-compulsive behavior (HP:0000722)2.19249229
61Asymmetric septal hypertrophy (HP:0001670)2.14814551
62Birth length less than 3rd percentile (HP:0003561)2.13743711
63Chromsome breakage (HP:0040012)2.13426729
64Rhinitis (HP:0012384)2.10601608
65Myoglobinuria (HP:0002913)2.10402258
66Hyponatremia (HP:0002902)2.09683704
67Hypoplastic ischia (HP:0003175)2.08358201
68Ventricular fibrillation (HP:0001663)2.06178112
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05053419
70Termporal pattern (HP:0011008)2.04770547
71Insidious onset (HP:0003587)2.04770547
72Abnormal sex determination (HP:0012244)1.99962774
73Sex reversal (HP:0012245)1.99962774
74Small intestinal stenosis (HP:0012848)1.98429184
75Duodenal stenosis (HP:0100867)1.98429184
76Abnormally folded helix (HP:0008544)1.98291135
77Enlarged epiphyses (HP:0010580)1.97650969
78Cutaneous melanoma (HP:0012056)1.96175041
79Abnormality of the ischium (HP:0003174)1.94840762
80Abnormality of the tricuspid valve (HP:0001702)1.94448020
81Abnormality of the aortic arch (HP:0012303)1.92517126
82Hypergonadotropic hypogonadism (HP:0000815)1.91852400
83Bronchiectasis (HP:0002110)1.90839552
84Abnormality of the columella (HP:0009929)1.87682959
85Hypoplasia of the uterus (HP:0000013)1.87387303
86Abnormality of dental color (HP:0011073)1.87028719
87Recurrent corneal erosions (HP:0000495)1.84930227
88Abnormal gallbladder morphology (HP:0012437)1.84348763
89Morphological abnormality of the inner ear (HP:0011390)1.83161564
90Renal dysplasia (HP:0000110)1.82999125
91Cortical dysplasia (HP:0002539)1.80840659
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.80009830
93Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79456834
94Renovascular hypertension (HP:0100817)1.79453251
95Acanthocytosis (HP:0001927)1.78295134
96Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77646097
97Overfolded helix (HP:0000396)1.76643913
98Squamous cell carcinoma (HP:0002860)1.75618001
99Abnormality of homocysteine metabolism (HP:0010919)1.75121640
100Homocystinuria (HP:0002156)1.75121640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.40567489
2PINK14.51100628
3RIPK43.54059467
4KSR23.02179071
5MARK32.79530577
6DDR22.53335381
7INSRR2.44033754
8LATS12.30886989
9MAP3K22.22946813
10EEF2K2.08293484
11BMPR22.05256716
12PLK22.00368085
13NEK21.98178423
14BRD41.97599135
15TESK11.84761585
16PIK3CG1.83766549
17NTRK31.79970122
18CLK11.75629686
19STK381.71847240
20MAP4K21.70923534
21TTK1.70226204
22CDK121.63923349
23MAP3K41.59679027
24RAF11.54215678
25WNK11.50902110
26CCNB11.46213418
27AKT31.40999555
28PNCK1.34701509
29BRSK21.33364493
30CDC71.26676321
31ZAK1.24668073
32BRAF1.14808563
33MST1R1.14695734
34MAP2K71.14680366
35MAPK151.13728575
36CAMK1G1.13298534
37LATS21.12461169
38SRPK11.07734754
39MAP3K81.03325135
40NME10.99328412
41RPS6KA50.98009675
42EIF2AK10.96943751
43MAP3K10.94891000
44NEK10.93664501
45KSR10.88054427
46CDK70.84150927
47TRPM70.83349082
48PDPK10.83092239
49RET0.79593174
50WNK40.79384883
51PRKG20.75590667
52BRSK10.74448382
53WEE10.72891742
54TYRO30.71976977
55PBK0.71344869
56STK38L0.69482067
57PDK10.69357777
58STK30.69253252
59CHEK10.68282031
60NEK60.67909721
61TSSK60.67516976
62TLK10.66016310
63CDK10.65652050
64ARAF0.63856987
65EIF2AK30.63121540
66CDK30.62687203
67PTK2B0.59699979
68ATM0.58919863
69CDK20.58227775
70CHEK20.57857620
71JAK20.57790582
72MTOR0.56838649
73RPS6KB20.55248392
74ATR0.53191248
75DYRK30.53145659
76SCYL20.51483867
77PAK10.50857876
78ICK0.47813418
79SIK20.46820841
80JAK30.46680452
81MAP3K60.46387489
82BLK0.45281292
83PRKG10.43514871
84MYLK0.43115237
85DAPK20.41527458
86CAMK1D0.40776666
87RPS6KA10.39460889
88GSK3B0.38700541
89PAK20.37606967
90OBSCN0.37060080
91PLK10.35832216
92BTK0.33031767
93MAPK10.32992630
94CDK40.32567388
95ROCK10.30992005
96TNIK0.30832965
97PRKAA20.30683178
98MAPKAPK50.30350783
99SGK10.29681193
100IRAK30.28551922

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.50588438
2Olfactory transduction_Homo sapiens_hsa047404.46922350
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.76520459
4Fatty acid biosynthesis_Homo sapiens_hsa000613.47016022
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.12541652
6RNA transport_Homo sapiens_hsa030133.05072339
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64768088
8One carbon pool by folate_Homo sapiens_hsa006702.57941641
9Butanoate metabolism_Homo sapiens_hsa006502.55031720
10Fanconi anemia pathway_Homo sapiens_hsa034602.10667417
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.94080004
12Type II diabetes mellitus_Homo sapiens_hsa049301.88615286
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.72024751
14Basal transcription factors_Homo sapiens_hsa030221.71046711
15Homologous recombination_Homo sapiens_hsa034401.70725297
16Mismatch repair_Homo sapiens_hsa034301.67440930
17Arginine biosynthesis_Homo sapiens_hsa002201.65127287
18DNA replication_Homo sapiens_hsa030301.60936981
19mRNA surveillance pathway_Homo sapiens_hsa030151.58485048
20Propanoate metabolism_Homo sapiens_hsa006401.41902544
21Pyruvate metabolism_Homo sapiens_hsa006201.41462336
22Nucleotide excision repair_Homo sapiens_hsa034201.34609546
23Gap junction_Homo sapiens_hsa045401.33980200
24Oocyte meiosis_Homo sapiens_hsa041141.32884938
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27644452
26Acute myeloid leukemia_Homo sapiens_hsa052211.25850609
27VEGF signaling pathway_Homo sapiens_hsa043701.23536342
28Dorso-ventral axis formation_Homo sapiens_hsa043201.22627711
29* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21084828
30Cell cycle_Homo sapiens_hsa041101.18944393
31Nitrogen metabolism_Homo sapiens_hsa009101.10645304
32Purine metabolism_Homo sapiens_hsa002301.06209756
33Apoptosis_Homo sapiens_hsa042101.02998908
34Antigen processing and presentation_Homo sapiens_hsa046121.00962488
35Viral carcinogenesis_Homo sapiens_hsa052031.00259055
36RNA degradation_Homo sapiens_hsa030181.00139766
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99264957
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98172384
39Taste transduction_Homo sapiens_hsa047420.97187334
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.96121166
41Fatty acid metabolism_Homo sapiens_hsa012120.95465787
42Carbon metabolism_Homo sapiens_hsa012000.94553006
43Selenocompound metabolism_Homo sapiens_hsa004500.90458127
44mTOR signaling pathway_Homo sapiens_hsa041500.89176690
45Alcoholism_Homo sapiens_hsa050340.87638754
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86379684
47Biosynthesis of amino acids_Homo sapiens_hsa012300.85511043
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84465732
49Spliceosome_Homo sapiens_hsa030400.84318863
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.80175121
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78321479
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73077993
53Non-small cell lung cancer_Homo sapiens_hsa052230.72209345
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70631257
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.70602772
56Systemic lupus erythematosus_Homo sapiens_hsa053220.69416455
57Prion diseases_Homo sapiens_hsa050200.65830690
58Non-homologous end-joining_Homo sapiens_hsa034500.65695055
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64391758
60ErbB signaling pathway_Homo sapiens_hsa040120.63077489
61Thyroid cancer_Homo sapiens_hsa052160.60327000
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.56666716
63HIF-1 signaling pathway_Homo sapiens_hsa040660.55861595
64Arginine and proline metabolism_Homo sapiens_hsa003300.54822315
65Influenza A_Homo sapiens_hsa051640.54737864
66Inositol phosphate metabolism_Homo sapiens_hsa005620.53913956
67Insulin signaling pathway_Homo sapiens_hsa049100.50427692
68Chronic myeloid leukemia_Homo sapiens_hsa052200.49490098
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48905038
70Phenylalanine metabolism_Homo sapiens_hsa003600.46543045
71Retinol metabolism_Homo sapiens_hsa008300.46327639
72ABC transporters_Homo sapiens_hsa020100.44657431
73Prolactin signaling pathway_Homo sapiens_hsa049170.42358101
74B cell receptor signaling pathway_Homo sapiens_hsa046620.42132610
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41989927
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40191185
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39071752
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.38337173
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36896427
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36357688
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.35234046
82Herpes simplex infection_Homo sapiens_hsa051680.35164430
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.34008902
84Base excision repair_Homo sapiens_hsa034100.33145331
85RNA polymerase_Homo sapiens_hsa030200.31419253
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31218704
87Measles_Homo sapiens_hsa051620.30204856
88Hedgehog signaling pathway_Homo sapiens_hsa043400.30038069
89Choline metabolism in cancer_Homo sapiens_hsa052310.29745319
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28593049
91Pyrimidine metabolism_Homo sapiens_hsa002400.27131782
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26698315
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26047638
94Metabolic pathways_Homo sapiens_hsa011000.25203799
95Estrogen signaling pathway_Homo sapiens_hsa049150.25150860
96T cell receptor signaling pathway_Homo sapiens_hsa046600.24797523
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24339669
98Epstein-Barr virus infection_Homo sapiens_hsa051690.23719532
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22312073
100Glioma_Homo sapiens_hsa052140.21658975

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »