ATXN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 37-306 CAG repeats (near the N-terminus), compared to 4-35 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.80390589
2cellular extravasation (GO:0045123)4.22082231
3positive regulation of granulocyte differentiation (GO:0030854)3.85346121
4positive regulation by symbiont of host defense response (GO:0052509)3.85194788
5modulation by symbiont of host defense response (GO:0052031)3.85194788
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85194788
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85194788
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.85194788
9modulation by symbiont of host immune response (GO:0052553)3.85194788
10histone H3-K4 trimethylation (GO:0080182)3.77063888
11response to interleukin-15 (GO:0070672)3.73204569
12tolerance induction (GO:0002507)3.70751039
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67464472
14negative regulation of T cell mediated immunity (GO:0002710)3.67214557
15leukocyte aggregation (GO:0070486)3.61247583
16B cell receptor signaling pathway (GO:0050853)3.60931254
17cytoplasmic mRNA processing body assembly (GO:0033962)3.53819017
18macrophage activation involved in immune response (GO:0002281)3.48552077
19positive regulation of gamma-delta T cell activation (GO:0046645)3.45181367
20cellular response to interleukin-15 (GO:0071350)3.45018302
21T cell migration (GO:0072678)3.44557565
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.35663904
23microglial cell activation (GO:0001774)3.32058991
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.31263683
25neutrophil mediated immunity (GO:0002446)3.30662423
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.28345321
27regulation of alpha-beta T cell proliferation (GO:0046640)3.20749234
28regulation of gamma-delta T cell differentiation (GO:0045586)3.20518579
29interferon-gamma production (GO:0032609)3.19622875
30hepatocyte apoptotic process (GO:0097284)3.15939263
31detection of other organism (GO:0098543)3.13353856
32regulation of gamma-delta T cell activation (GO:0046643)3.09837559
33response to peptidoglycan (GO:0032494)3.07954542
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05685989
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05685989
36myeloid leukocyte mediated immunity (GO:0002444)3.04539677
37regulation of granulocyte differentiation (GO:0030852)3.04464757
38activated T cell proliferation (GO:0050798)3.04325809
39detection of molecule of bacterial origin (GO:0032490)3.04153986
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02177135
41positive regulation of alpha-beta T cell proliferation (GO:0046641)3.01658938
42negative regulation of erythrocyte differentiation (GO:0045647)2.99922721
43regulation of regulatory T cell differentiation (GO:0045589)2.99001288
44germinal center formation (GO:0002467)2.97165158
45positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96015597
46negative regulation of T-helper cell differentiation (GO:0045623)2.95806543
47negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95806543
48neutrophil activation involved in immune response (GO:0002283)2.95075190
49regulation of hypersensitivity (GO:0002883)2.92417012
50alpha-beta T cell differentiation (GO:0046632)2.91703411
51coronary vasculature morphogenesis (GO:0060977)2.90678330
52negative regulation of interleukin-12 production (GO:0032695)2.90062694
53macrophage activation (GO:0042116)2.89563271
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88299494
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87725411
56response to host immune response (GO:0052572)2.87725411
57detection of bacterium (GO:0016045)2.85560354
58growth hormone receptor signaling pathway (GO:0060396)2.85465699
59antigen processing and presentation of endogenous antigen (GO:0019883)2.84888254
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84819742
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84164545
62positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.83502547
63regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.83502547
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83003954
65response to host (GO:0075136)2.83003954
66response to host defenses (GO:0052200)2.83003954
67response to type I interferon (GO:0034340)2.80990465
68alpha-beta T cell activation (GO:0046631)2.80849560
69CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.80685315
70T-helper cell differentiation (GO:0042093)2.80685315
71neutrophil activation (GO:0042119)2.80616930
72detection of external biotic stimulus (GO:0098581)2.80008599
73type I interferon signaling pathway (GO:0060337)2.79571132
74cellular response to type I interferon (GO:0071357)2.79571132
75negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.79421307
76histone H3-K36 demethylation (GO:0070544)2.78091498
77antigen receptor-mediated signaling pathway (GO:0050851)2.77999439
78retrograde transport, vesicle recycling within Golgi (GO:0000301)2.77556803
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77341304
80negative regulation of leukocyte mediated immunity (GO:0002704)2.77328971
81phospholipid homeostasis (GO:0055091)2.76256316
82negative regulation of cell killing (GO:0031342)2.75761870
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.75761870
84myeloid cell activation involved in immune response (GO:0002275)2.74616357
85production of molecular mediator involved in inflammatory response (GO:0002532)2.68489250
86negative regulation of stress fiber assembly (GO:0051497)2.68453068
87negative regulation of B cell proliferation (GO:0030889)2.67807559
88positive regulation of interferon-alpha production (GO:0032727)2.67359941
89protein targeting to Golgi (GO:0000042)2.66186602
90interleukin-1-mediated signaling pathway (GO:0070498)2.58603440
91phospholipid efflux (GO:0033700)2.57565129
92negative thymic T cell selection (GO:0045060)2.57459046
93negative T cell selection (GO:0043383)2.56553364
94regulation of interleukin-12 biosynthetic process (GO:0045075)2.55885103
95positive thymic T cell selection (GO:0045059)2.54847976
96regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.53864871
97positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.53864871
98positive regulation of B cell differentiation (GO:0045579)2.52772601
99CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.52549443
100negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50347328
101negative regulation of translation, ncRNA-mediated (GO:0040033)2.50347328
102regulation of translation, ncRNA-mediated (GO:0045974)2.50347328
103NIK/NF-kappaB signaling (GO:0038061)2.49599286
104thymic T cell selection (GO:0045061)2.49501802
105establishment of protein localization to Golgi (GO:0072600)2.48879993
106negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.45429398
107desmosome organization (GO:0002934)2.44470115
108T cell selection (GO:0045058)2.43925224
109positive regulation of respiratory burst (GO:0060267)2.43117345
110histone H3-K4 methylation (GO:0051568)2.39668087
111negative regulation of bone resorption (GO:0045779)2.38323945
112positive regulation of histone deacetylation (GO:0031065)2.36785090
113regulation of interferon-beta biosynthetic process (GO:0045357)2.36211333
114cellular response to growth hormone stimulus (GO:0071378)2.35562697
115positive T cell selection (GO:0043368)2.35400855
116regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.35376962
117positive regulation of mRNA catabolic process (GO:0061014)2.34147570
118positive regulation of cholesterol efflux (GO:0010875)2.33916180
119negative regulation of lipid storage (GO:0010888)2.32718597
120peptidyl-lysine trimethylation (GO:0018023)2.31736500
121alpha-beta T cell differentiation involved in immune response (GO:0002293)2.29871654
122alpha-beta T cell activation involved in immune response (GO:0002287)2.29871654
123T cell differentiation involved in immune response (GO:0002292)2.29871654
124positive regulation of sterol transport (GO:0032373)2.27841934
125positive regulation of cholesterol transport (GO:0032376)2.27841934
126tryptophan metabolic process (GO:0006568)2.26944987
127regulation of cholesterol homeostasis (GO:2000188)2.25991700
128definitive hemopoiesis (GO:0060216)2.22372596
129regulation of bile acid biosynthetic process (GO:0070857)2.21924315
130tryptophan catabolic process (GO:0006569)2.20559766
131indole-containing compound catabolic process (GO:0042436)2.20559766
132indolalkylamine catabolic process (GO:0046218)2.20559766
133lymph vessel development (GO:0001945)2.19776063
134positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.19307953
135CD4-positive, alpha-beta T cell activation (GO:0035710)2.18646591
136positive regulation of p38MAPK cascade (GO:1900745)2.16261595
137chemical homeostasis within a tissue (GO:0048875)2.16235550
138regulation of T cell tolerance induction (GO:0002664)2.15910514
139protein localization to endosome (GO:0036010)2.15316969
140cellular response to ethanol (GO:0071361)2.14204196
141I-kappaB phosphorylation (GO:0007252)2.12223262
142positive regulation of tolerance induction (GO:0002645)2.12199803
143regulation of RIG-I signaling pathway (GO:0039535)2.11536536
144negative regulation of lipase activity (GO:0060192)2.11133697
145regulation of B cell differentiation (GO:0045577)2.08988767
146JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.06263520
147positive regulation of natural killer cell differentiation (GO:0032825)2.06207917
148regulation of tolerance induction (GO:0002643)2.05511945
149regulation of germinal center formation (GO:0002634)2.04885057
150surfactant homeostasis (GO:0043129)2.04768982
151regulation of mRNA catabolic process (GO:0061013)2.04200949
152transcytosis (GO:0045056)2.02734757
153plasma lipoprotein particle assembly (GO:0034377)2.01597416
154response to muramyl dipeptide (GO:0032495)2.01256315
155negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)1.99003358
156aromatic amino acid family catabolic process (GO:0009074)1.98816800
157protein carboxylation (GO:0018214)1.98478048
158peptidyl-glutamic acid carboxylation (GO:0017187)1.98478048
159urea cycle (GO:0000050)1.98135323
160urea metabolic process (GO:0019627)1.98135323
161negative regulation of bone remodeling (GO:0046851)1.97383790
162negative regulation of actin filament bundle assembly (GO:0032232)1.97200358
163hydrogen peroxide biosynthetic process (GO:0050665)1.96618923
164positive regulation of fatty acid beta-oxidation (GO:0032000)1.96568118
165positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.96394622
166triglyceride-rich lipoprotein particle remodeling (GO:0034370)1.96098193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34372847
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10301666
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.62898011
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.35440115
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.31665061
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29373095
7GATA1_22025678_ChIP-Seq_K562_Human2.22286597
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13264443
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12748792
10RUNX_20019798_ChIP-Seq_JUKART_Human2.11765561
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04716282
12LXR_22158963_ChIP-Seq_LIVER_Mouse1.96268785
13TP63_17297297_ChIP-ChIP_HaCaT_Human1.93900015
14VDR_24763502_ChIP-Seq_THP-1_Human1.93216263
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91764639
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91138967
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.89235695
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87712819
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86880023
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86655188
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83166456
22MYC_22102868_ChIP-Seq_BL_Human1.82627600
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80844947
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80117622
25UTX_26944678_Chip-Seq_JUKART_Human1.77858224
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.74491197
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74292677
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69170377
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68401585
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67198739
31SPI1_23547873_ChIP-Seq_NB4_Human1.63679113
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63191944
33* GATA2_21666600_ChIP-Seq_HMVEC_Human1.61891339
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58963525
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.58653322
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56362627
37* IRF8_27001747_Chip-Seq_BMDM_Mouse1.55413470
38SCL_19346495_ChIP-Seq_HPC-7_Human1.54929937
39VDR_21846776_ChIP-Seq_THP-1_Human1.50288242
40GATA3_26560356_Chip-Seq_TH2_Human1.49673249
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49437620
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47658342
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47448546
44TP53_16413492_ChIP-PET_HCT116_Human1.45696380
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40239209
46MAF_26560356_Chip-Seq_TH2_Human1.39949912
47GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39699559
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.39549828
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34585436
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.33727367
51KDM2B_26808549_Chip-Seq_DND41_Human1.33070046
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32594246
53* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32140976
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31932131
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.31831868
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31110730
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30674795
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29618268
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27846094
60VDR_24787735_ChIP-Seq_THP-1_Human1.27458988
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26889990
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26636038
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.26619279
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25997244
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25501278
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25410615
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23029490
68* GATA1_19941827_ChIP-Seq_MEL_Mouse1.22978059
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.22923185
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.22861950
71AR_21572438_ChIP-Seq_LNCaP_Human1.22841404
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20984655
73RXR_22108803_ChIP-Seq_LS180_Human1.20000500
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.18542236
75BCAT_22108803_ChIP-Seq_LS180_Human1.16885832
76AHR_22903824_ChIP-Seq_MCF-7_Human1.12842889
77* TCF7_22412390_ChIP-Seq_EML_Mouse1.11596987
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11037988
79* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10981135
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08681471
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.08106666
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07209065
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07209065
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06824272
85CJUN_26792858_Chip-Seq_BT549_Human1.06494860
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05548732
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.04218118
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04024853
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02150669
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01974356
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.00168762
92TP63_23658742_ChIP-Seq_EP156T_Human0.99454470
93MYB_26560356_Chip-Seq_TH1_Human0.99328718
94* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99263691
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99117956
96SMRT_27268052_Chip-Seq_Bcells_Human0.99080059
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98756417
98* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98345494
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.98308649
100TP53_18474530_ChIP-ChIP_U2OS_Human0.98105211
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97251726
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96908191
103SMAD3_21741376_ChIP-Seq_HESCs_Human0.96893430
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96129279
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95191849
106GATA2_19941826_ChIP-Seq_K562_Human0.95012184
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94912217
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94053164
109MYB_26560356_Chip-Seq_TH2_Human0.93917414
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93802117
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93232792
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.92755637
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91907497
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90700566
115DROSHA_22980978_ChIP-Seq_HELA_Human0.90261455
116GATA1_19941826_ChIP-Seq_K562_Human0.89982793
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89733513
118STAT3_23295773_ChIP-Seq_U87_Human0.89609290
119* ER_23166858_ChIP-Seq_MCF-7_Human0.89581067
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89524268
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88710173
122CDX2_22108803_ChIP-Seq_LS180_Human0.88535262
123GBX2_23144817_ChIP-Seq_PC3_Human0.87184095
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.86836675
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.86836675
126SMAD4_21799915_ChIP-Seq_A2780_Human0.86695064
127SPI1_23127762_ChIP-Seq_K562_Human0.86612120
128* PU_27001747_Chip-Seq_BMDM_Mouse0.86284698
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85611298
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85419115
131GATA3_27048872_Chip-Seq_THYMUS_Human0.85002611
132CIITA_25753668_ChIP-Seq_RAJI_Human0.84609089
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84209134
134AR_25329375_ChIP-Seq_VCAP_Human0.83591515
135MAF_26560356_Chip-Seq_TH1_Human0.83249845
136SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82357367
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82357367
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81362870
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.81249077
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81244789
141PKCTHETA_26484144_Chip-Seq_BREAST_Human0.78414988
142* RUNX1_27514584_Chip-Seq_MCF-7_Human0.75505179
143* GATA3_26560356_Chip-Seq_TH1_Human0.72587749
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.71732667
145TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.68532052
146CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67386635
147CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.66821093
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.65377652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.79600224
2MP0003300_gastrointestinal_ulcer3.08756129
3MP0005360_urolithiasis2.73032143
4MP0005365_abnormal_bile_salt2.61205246
5MP0002166_altered_tumor_susceptibility2.51582163
6MP0003252_abnormal_bile_duct2.37560482
7MP0004510_myositis2.36865078
8MP0001790_abnormal_immune_system2.36543329
9MP0005387_immune_system_phenotype2.36543329
10MP0008057_abnormal_DNA_replication2.36113467
11MP0002138_abnormal_hepatobiliary_system2.33997222
12MP0002139_abnormal_hepatobiliary_system2.31370267
13MP0005085_abnormal_gallbladder_physiolo2.20134966
14MP0000685_abnormal_immune_system2.18946675
15MP0002009_preneoplasia2.15937300
16MP0001873_stomach_inflammation2.13491179
17MP0001835_abnormal_antigen_presentation2.05861447
18MP0000703_abnormal_thymus_morphology2.02318397
19MP0003045_fibrosis1.99360037
20MP0001346_abnormal_lacrimal_gland1.97992760
21MP0002006_tumorigenesis1.95707164
22MP0001800_abnormal_humoral_immune1.83505505
23MP0003724_increased_susceptibility_to1.78969907
24MP0000689_abnormal_spleen_morphology1.76319560
25MP0004947_skin_inflammation1.75748635
26MP0002722_abnormal_immune_system1.74703945
27MP0003453_abnormal_keratinocyte_physiol1.66499214
28MP0010234_abnormal_vibrissa_follicle1.65719135
29MP0003828_pulmonary_edema1.64477186
30MP0003763_abnormal_thymus_physiology1.64278914
31MP0002723_abnormal_immune_serum1.57255751
32MP0009333_abnormal_splenocyte_physiolog1.56607736
33MP0002419_abnormal_innate_immunity1.54200905
34MP0000383_abnormal_hair_follicle1.53433237
35MP0008875_abnormal_xenobiotic_pharmacok1.53194569
36MP0002452_abnormal_antigen_presenting1.52537603
37MP0002796_impaired_skin_barrier1.51750147
38MP0003183_abnormal_peptide_metabolism1.49529975
39MP0001851_eye_inflammation1.49115576
40MP0010678_abnormal_skin_adnexa1.47840663
41MP0005409_darkened_coat_color1.46814751
42MP0002998_abnormal_bone_remodeling1.46423400
43MP0005397_hematopoietic_system_phenotyp1.46301638
44MP0001545_abnormal_hematopoietic_system1.46301638
45MP0000569_abnormal_digit_pigmentation1.45916192
46MP0010329_abnormal_lipoprotein_level1.45649928
47MP0003172_abnormal_lysosome_physiology1.43903745
48MP0010368_abnormal_lymphatic_system1.43752631
49MP0000465_gastrointestinal_hemorrhage1.43091096
50MP0009764_decreased_sensitivity_to1.41744889
51MP0003191_abnormal_cellular_cholesterol1.41577452
52MP0009278_abnormal_bone_marrow1.40016706
53MP0003436_decreased_susceptibility_to1.39429400
54MP0005671_abnormal_response_to1.39337702
55MP0005076_abnormal_cell_differentiation1.39257526
56MP0005075_abnormal_melanosome_morpholog1.38849236
57MP0002420_abnormal_adaptive_immunity1.38827563
58MP0005310_abnormal_salivary_gland1.38256286
59MP0001819_abnormal_immune_cell1.37455960
60MP0008961_abnormal_basal_metabolism1.34428957
61MP0000015_abnormal_ear_pigmentation1.33216111
62MP0004185_abnormal_adipocyte_glucose1.32904441
63MP0005000_abnormal_immune_tolerance1.32669710
64MP0002877_abnormal_melanocyte_morpholog1.31860535
65MP0001666_abnormal_nutrient_absorption1.28798521
66MP0000609_abnormal_liver_physiology1.28304450
67MP0001879_abnormal_lymphatic_vessel1.27787695
68MP0001853_heart_inflammation1.27366973
69MP0003303_peritoneal_inflammation1.25397474
70MP0005464_abnormal_platelet_physiology1.24431848
71MP0002928_abnormal_bile_duct1.23828436
72MP0003868_abnormal_feces_composition1.21925154
73MP0009780_abnormal_chondrocyte_physiolo1.21609596
74MP0005451_abnormal_body_composition1.20071998
75MP0001216_abnormal_epidermal_layer1.19552321
76MP0004808_abnormal_hematopoietic_stem1.17742492
77MP0003656_abnormal_erythrocyte_physiolo1.16920945
78MP0010155_abnormal_intestine_physiology1.15348668
79MP0001845_abnormal_inflammatory_respons1.15252605
80MP0005167_abnormal_blood-brain_barrier1.15050562
81MP0005025_abnormal_response_to1.14956499
82MP0002060_abnormal_skin_morphology1.14776807
83MP0002971_abnormal_brown_adipose1.13507669
84MP0004381_abnormal_hair_follicle1.10196436
85MP0004883_abnormal_blood_vessel1.09731160
86MP0009115_abnormal_fat_cell1.09588516
87MP0000716_abnormal_immune_system1.07313415
88MP0002933_joint_inflammation1.04998034
89MP0002398_abnormal_bone_marrow1.04747741
90MP0002148_abnormal_hypersensitivity_rea1.04652346
91MP0000013_abnormal_adipose_tissue1.01143675
92MP0003091_abnormal_cell_migration0.99565741
93MP0006082_CNS_inflammation0.98889411
94MP0001533_abnormal_skeleton_physiology0.98883196
95MP0002118_abnormal_lipid_homeostasis0.98416376
96MP0003787_abnormal_imprinting0.98134234
97MP0005174_abnormal_tail_pigmentation0.95261970
98MP0009785_altered_susceptibility_to0.94658968
99MP0002405_respiratory_system_inflammati0.92403182
100MP0005666_abnormal_adipose_tissue0.90001912
101MP0000377_abnormal_hair_follicle0.89813445
102MP0001191_abnormal_skin_condition0.89746392
103MP0003943_abnormal_hepatobiliary_system0.88887030
104MP0008260_abnormal_autophagy0.87867314
105MP0008469_abnormal_protein_level0.86202732
106MP0004264_abnormal_extraembryonic_tissu0.86117892
107MP0002396_abnormal_hematopoietic_system0.85983263
108MP0004130_abnormal_muscle_cell0.85505184
109MP0005375_adipose_tissue_phenotype0.84914076
110MP0002132_abnormal_respiratory_system0.83597852
111MP0002332_abnormal_exercise_endurance0.83543989
112MP0003866_abnormal_defecation0.83366658
113MP0003646_muscle_fatigue0.83150875
114MP0008877_abnormal_DNA_methylation0.82024159
115MP0005164_abnormal_response_to0.80753923
116MP0000767_abnormal_smooth_muscle0.80407743
117MP0000858_altered_metastatic_potential0.79967806
118MP0004019_abnormal_vitamin_homeostasis0.79807984
119MP0002098_abnormal_vibrissa_morphology0.79481522
120MP0000003_abnormal_adipose_tissue0.75366657
121MP0008995_early_reproductive_senescence0.74981865
122MP0004484_altered_response_of0.73874229
123MP0002019_abnormal_tumor_incidence0.73208566
124MP0002168_other_aberrant_phenotype0.73022843
125MP0003941_abnormal_skin_development0.72925366
126MP0002429_abnormal_blood_cell0.71285274
127MP0008004_abnormal_stomach_pH0.68903206
128MP0000249_abnormal_blood_vessel0.67888079
129MP0003448_altered_tumor_morphology0.67025440
130MP0009763_increased_sensitivity_to0.64177709
131MP0002277_abnormal_respiratory_mucosa0.63901055
132MP0009765_abnormal_xenobiotic_induced0.62419076
133MP0000371_diluted_coat_color0.57002943
134MP0005390_skeleton_phenotype0.55152986
135MP0003690_abnormal_glial_cell0.54238004
136MP0003221_abnormal_cardiomyocyte_apopto0.53577855
137MP0001765_abnormal_ion_homeostasis0.53218630

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.87583316
2Eczematoid dermatitis (HP:0000976)4.00655697
3Orchitis (HP:0100796)3.68979676
4Elevated erythrocyte sedimentation rate (HP:0003565)3.66425161
5Autoimmune thrombocytopenia (HP:0001973)3.55308787
6Gastrointestinal infarctions (HP:0005244)3.43042373
7Abnormality of T cells (HP:0002843)3.43033006
8Myocardial infarction (HP:0001658)3.31343771
9Recurrent bacterial skin infections (HP:0005406)3.13480508
10Leukocytosis (HP:0001974)3.05446409
11Recurrent viral infections (HP:0004429)3.01847075
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.95045229
13Recurrent fungal infections (HP:0002841)2.94929573
14Lip pit (HP:0100267)2.94346935
15Abnormal delayed hypersensitivity skin test (HP:0002963)2.90271521
16Spontaneous hematomas (HP:0007420)2.84976104
17Abnormality of macrophages (HP:0004311)2.83493446
18Chest pain (HP:0100749)2.80021085
19Colitis (HP:0002583)2.70544221
20Abnormality of T cell physiology (HP:0011840)2.69476506
21Deep venous thrombosis (HP:0002625)2.62422480
22Papilledema (HP:0001085)2.62338674
23Severe combined immunodeficiency (HP:0004430)2.60711498
24Hemoptysis (HP:0002105)2.60220215
25Gingival bleeding (HP:0000225)2.58565483
26Recurrent bronchitis (HP:0002837)2.57474677
27Toxemia of pregnancy (HP:0100603)2.55184602
28Keratoconjunctivitis (HP:0001096)2.54484194
29Panhypogammaglobulinemia (HP:0003139)2.53877235
30Viral hepatitis (HP:0006562)2.53170558
31Chronic otitis media (HP:0000389)2.50883124
32Mitral stenosis (HP:0001718)2.50246022
33Ectropion (HP:0000656)2.48883723
34Stomach cancer (HP:0012126)2.46579245
35Subacute progressive viral hepatitis (HP:0006572)2.46339325
36Recurrent gram-negative bacterial infections (HP:0005420)2.46043909
37Obstructive lung disease (HP:0006536)2.43073907
38Chronic obstructive pulmonary disease (HP:0006510)2.43073907
39Recurrent abscess formation (HP:0002722)2.41516518
40Abnormality of T cell number (HP:0011839)2.40244506
41Agammaglobulinemia (HP:0004432)2.39374775
42Neoplasm of the tracheobronchial system (HP:0100552)2.36675199
43Prolonged partial thromboplastin time (HP:0003645)2.36300334
44Inflammation of the large intestine (HP:0002037)2.31660589
45Recurrent skin infections (HP:0001581)2.23907306
46Arterial thrombosis (HP:0004420)2.23875577
47Increased IgE level (HP:0003212)2.23776795
48Chronic diarrhea (HP:0002028)2.22582900
49Eosinophilia (HP:0001880)2.22130653
50Neonatal hypoglycemia (HP:0001998)2.18544716
51Mediastinal lymphadenopathy (HP:0100721)2.17797232
52Hypochromic anemia (HP:0001931)2.16390275
53Truncal obesity (HP:0001956)2.14385561
54Hyperkalemia (HP:0002153)2.14224062
55Hematochezia (HP:0002573)2.14017363
56Thick nail (HP:0001805)2.12213075
57IgG deficiency (HP:0004315)2.11848729
58T lymphocytopenia (HP:0005403)2.10404858
59Hypoalphalipoproteinemia (HP:0003233)2.10023933
60Stomatitis (HP:0010280)2.09190753
61Autoimmune hemolytic anemia (HP:0001890)2.08828461
62Lymphopenia (HP:0001888)2.08635458
63Portal hypertension (HP:0001409)2.08604860
64Gingivitis (HP:0000230)2.08227263
65Acute myeloid leukemia (HP:0004808)2.07688005
66Xanthomatosis (HP:0000991)2.07427928
67Polycythemia (HP:0001901)2.07425558
68Alveolar cell carcinoma (HP:0006519)2.07100484
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.05324686
70Abnormality of the hepatic vasculature (HP:0006707)2.04253954
71Intrahepatic cholestasis (HP:0001406)2.03993814
72Hypochromic microcytic anemia (HP:0004840)2.03849447
73Thyroiditis (HP:0100646)2.03830520
74Narrow palate (HP:0000189)2.03699111
75Entropion (HP:0000621)2.02990848
76Gangrene (HP:0100758)2.01488657
77Verrucae (HP:0200043)2.00824450
78Papilloma (HP:0012740)2.00824450
79Absent frontal sinuses (HP:0002688)2.00227654
80Gastrointestinal inflammation (HP:0004386)1.99356053
81Abnormality of the common coagulation pathway (HP:0010990)1.99245531
82Vasculitis (HP:0002633)1.99212889
83Esophageal varix (HP:0002040)1.98416199
84Hyperlipoproteinemia (HP:0010980)1.97787011
85Hyperglycemia (HP:0003074)1.97028682
86Abnormality of the pleura (HP:0002103)1.95836845
87Encephalitis (HP:0002383)1.95775136
88Spondylolisthesis (HP:0003302)1.95619830
89Abnormality of the columella (HP:0009929)1.92932164
90Cellulitis (HP:0100658)1.92763739
91Abnormality of the prostate (HP:0008775)1.92099581
92Fatigue (HP:0012378)1.91848327
93Milia (HP:0001056)1.91372178
94Chronic mucocutaneous candidiasis (HP:0002728)1.91056466
95Recurrent cutaneous fungal infections (HP:0011370)1.91056466
96Anorexia (HP:0002039)1.90342444
97Long eyelashes (HP:0000527)1.88426178
98Combined immunodeficiency (HP:0005387)1.87257065
99Hypergammaglobulinemia (HP:0010702)1.86833467
100Joint swelling (HP:0001386)1.86274429
101Increased IgM level (HP:0003496)1.85971249
102Prolonged bleeding time (HP:0003010)1.85882871
103Abnormality of B cell number (HP:0010975)1.85372219
104B lymphocytopenia (HP:0010976)1.85372219
105* Slow saccadic eye movements (HP:0000514)1.82628648
106Urticaria (HP:0001025)1.82140367
107Abnormality of proline metabolism (HP:0010907)1.81561193
108Hydroxyprolinuria (HP:0003080)1.81561193
109Myositis (HP:0100614)1.81524745
110Retrobulbar optic neuritis (HP:0100654)1.81078867
111Optic neuritis (HP:0100653)1.81078867
112Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80992505
113Syringomyelia (HP:0003396)1.80661383
114Spinal cord lesions (HP:0100561)1.80661383
115Dislocated radial head (HP:0003083)1.80232273
116Osteomyelitis (HP:0002754)1.80079899
117Conjugated hyperbilirubinemia (HP:0002908)1.79928843
118Joint hemorrhage (HP:0005261)1.79774173
119Hypoglycemic coma (HP:0001325)1.79384660
120Granulocytopenia (HP:0001913)1.79250546
121Axonal loss (HP:0003447)1.79112570
122Periodontitis (HP:0000704)1.79103255
123Hypoplasia of the thymus (HP:0000778)1.78137509
124Prominent nose (HP:0000448)1.77541108
125Hypercholesterolemia (HP:0003124)1.77232291
126Abnormality of eosinophils (HP:0001879)1.75825818
127Epistaxis (HP:0000421)1.75737510
128Aplasia/Hypoplasia of the thymus (HP:0010515)1.75019080
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.74558770
130Meningitis (HP:0001287)1.73748326
131Pulmonary embolism (HP:0002204)1.73270032
132Limb hypertonia (HP:0002509)1.72779220
133Sepsis (HP:0100806)1.72350034
134Abnormality of the nasal septum (HP:0000419)1.71843042
135IgM deficiency (HP:0002850)1.71429863
136Pustule (HP:0200039)1.71297527
137Decreased circulating renin level (HP:0003351)1.71099745
138Pulmonary infiltrates (HP:0002113)1.71014440
139Keratoconjunctivitis sicca (HP:0001097)1.68628178
140Urethral obstruction (HP:0000796)1.68036578
141Homocystinuria (HP:0002156)1.66937501
142Abnormality of homocysteine metabolism (HP:0010919)1.66937501
143Alopecia of scalp (HP:0002293)1.65009812
144Abnormality of methionine metabolism (HP:0010901)1.64391909
145Tetraparesis (HP:0002273)1.63630257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.10553528
2INSRR2.60276666
3TAOK32.44069756
4LATS12.37150834
5NUAK12.16594447
6DMPK2.15543016
7MAP4K12.14805336
8MAP3K132.05534834
9BLK2.04642057
10IRAK32.04610906
11JAK11.98533876
12PRPF4B1.93591746
13SIK11.82514290
14PIK3CG1.76017138
15FRK1.75458025
16IKBKE1.74555768
17FGFR31.73022693
18MAP3K31.67541791
19TXK1.65877079
20FGFR41.65649917
21TYK21.61588209
22CAMK1G1.59637628
23MAP3K71.58853478
24PRKAA21.43253609
25TNIK1.43216805
26EPHA31.43066018
27CAMK1D1.41339933
28NLK1.40473985
29SIK21.39839507
30EPHB11.38651030
31CDK121.37917762
32MARK21.36679766
33TNK21.32155311
34JAK31.27048969
35STK31.25925902
36TEC1.24148535
37IKBKB1.22860999
38ITK1.21865344
39KIT1.20240962
40TGFBR21.19900989
41SGK31.16645392
42TBK11.12740057
43AKT31.11973498
44SGK21.10869362
45MARK31.10309767
46CHUK1.10157704
47MAP2K31.10063733
48RIPK41.09626834
49PIK3CA1.07849348
50BMPR21.05685824
51YES11.05283056
52BRD41.03750339
53MAP3K61.01804458
54CAMKK20.98691785
55LYN0.98684017
56PRKD20.97394650
57PTK60.97100238
58TIE10.95062940
59HCK0.94916719
60TRIB30.94554635
61CSK0.93662920
62TAOK10.87230468
63JAK20.86101918
64PRKCQ0.85567508
65CDK60.84972824
66IRAK20.83956611
67STK100.82935444
68MAPK150.81719632
69FGFR20.81030388
70PIM10.79747141
71PDGFRB0.79604963
72WNK10.79005263
73SYK0.77743141
74NEK60.77375407
75ERN10.74803738
76MAPK70.74088137
77PRKCH0.73865946
78MAPK110.73538962
79PTK2B0.73536791
80MAP3K100.72366819
81CDK90.71994632
82RIPK10.70384908
83CDC42BPA0.70048552
84ZAP700.68941731
85MELK0.67873165
86CDK40.65975821
87IRAK40.65814118
88SGK2230.65430976
89SGK4940.65430976
90MAPK120.65277526
91STK240.64756311
92CAMKK10.61647890
93BTK0.61570755
94LCK0.60837083
95IGF1R0.60038832
96HIPK20.59846014
97MAP3K20.59683399
98SGK10.59272017
99FGR0.58735062
100ABL10.56207747
101MKNK20.55123565
102NEK90.54553197
103IRAK10.54132419
104CSF1R0.53904849
105MAP2K20.53692508
106EPHA40.53665381
107MAP3K10.52020000
108TRPM70.51948442
109RPS6KL10.51187904
110RPS6KC10.51187904
111RPS6KA60.50150634
112PDPK10.48896863
113STK110.48445184
114DYRK1B0.47544701
115SIK30.46602204
116FES0.45728072
117RET0.42597260
118EGFR0.42551074
119GRK60.41701011
120PRKAA10.41037384
121PDK10.40974490
122CAMK40.40502668
123MTOR0.39999465
124STK380.39885003
125PTK20.39644282

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053321.92494418
2Caffeine metabolism_Homo sapiens_hsa002321.79923162
3Nitrogen metabolism_Homo sapiens_hsa009101.77809611
4B cell receptor signaling pathway_Homo sapiens_hsa046621.74368794
5Osteoclast differentiation_Homo sapiens_hsa043801.73541287
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.69098117
7Autoimmune thyroid disease_Homo sapiens_hsa053201.66400611
8Non-small cell lung cancer_Homo sapiens_hsa052231.64495424
9Staphylococcus aureus infection_Homo sapiens_hsa051501.64434269
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.64351590
11Primary immunodeficiency_Homo sapiens_hsa053401.59814568
12Lysine degradation_Homo sapiens_hsa003101.56796112
13ABC transporters_Homo sapiens_hsa020101.45719333
14Complement and coagulation cascades_Homo sapiens_hsa046101.45700952
15Vitamin digestion and absorption_Homo sapiens_hsa049771.37230796
16Dorso-ventral axis formation_Homo sapiens_hsa043201.35971638
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34196048
18Type I diabetes mellitus_Homo sapiens_hsa049401.30866631
19Arginine biosynthesis_Homo sapiens_hsa002201.30358663
20T cell receptor signaling pathway_Homo sapiens_hsa046601.29112666
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.23253033
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.22567016
23Circadian rhythm_Homo sapiens_hsa047101.18512967
24TNF signaling pathway_Homo sapiens_hsa046681.17097657
25Renal cell carcinoma_Homo sapiens_hsa052111.13571087
26Endometrial cancer_Homo sapiens_hsa052131.13514834
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12903123
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12184266
29mTOR signaling pathway_Homo sapiens_hsa041501.09409825
30Antigen processing and presentation_Homo sapiens_hsa046121.09243841
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08175898
32Insulin resistance_Homo sapiens_hsa049311.04745285
33Measles_Homo sapiens_hsa051621.04307890
34Leishmaniasis_Homo sapiens_hsa051401.03924661
35Tryptophan metabolism_Homo sapiens_hsa003801.03788738
36Toxoplasmosis_Homo sapiens_hsa051451.02205213
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01487696
38VEGF signaling pathway_Homo sapiens_hsa043701.01378470
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00909923
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99170222
41Type II diabetes mellitus_Homo sapiens_hsa049300.98868378
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97814640
43Adherens junction_Homo sapiens_hsa045200.97502815
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.94825337
45Notch signaling pathway_Homo sapiens_hsa043300.93524169
46Influenza A_Homo sapiens_hsa051640.93070943
47Colorectal cancer_Homo sapiens_hsa052100.92589248
48Hematopoietic cell lineage_Homo sapiens_hsa046400.92366341
49Platelet activation_Homo sapiens_hsa046110.92133314
50Acute myeloid leukemia_Homo sapiens_hsa052210.90851860
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90439977
52Chemokine signaling pathway_Homo sapiens_hsa040620.87854240
53Bile secretion_Homo sapiens_hsa049760.87443747
54ErbB signaling pathway_Homo sapiens_hsa040120.86857295
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.86726219
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85819816
57FoxO signaling pathway_Homo sapiens_hsa040680.85386549
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84610726
59PPAR signaling pathway_Homo sapiens_hsa033200.84074246
60Asthma_Homo sapiens_hsa053100.84032583
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83162680
62Legionellosis_Homo sapiens_hsa051340.82257951
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81324577
64Pancreatic cancer_Homo sapiens_hsa052120.80507640
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80097119
66Fatty acid degradation_Homo sapiens_hsa000710.79201278
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79183655
68African trypanosomiasis_Homo sapiens_hsa051430.79144542
69Apoptosis_Homo sapiens_hsa042100.78613923
70Thyroid cancer_Homo sapiens_hsa052160.77902969
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.77543092
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.77504133
73Inositol phosphate metabolism_Homo sapiens_hsa005620.77174993
74Prolactin signaling pathway_Homo sapiens_hsa049170.76351249
75Viral carcinogenesis_Homo sapiens_hsa052030.76148431
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75659367
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75607053
78Chronic myeloid leukemia_Homo sapiens_hsa052200.73426507
79HTLV-I infection_Homo sapiens_hsa051660.72964628
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72567889
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72326529
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71501831
83Prostate cancer_Homo sapiens_hsa052150.71218221
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69529899
85Retinol metabolism_Homo sapiens_hsa008300.68822745
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.68414221
87beta-Alanine metabolism_Homo sapiens_hsa004100.67551169
88Choline metabolism in cancer_Homo sapiens_hsa052310.67065976
89Glioma_Homo sapiens_hsa052140.66555677
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66523819
91Hepatitis C_Homo sapiens_hsa051600.65974870
92Other glycan degradation_Homo sapiens_hsa005110.64711328
93Hepatitis B_Homo sapiens_hsa051610.64065133
94Epstein-Barr virus infection_Homo sapiens_hsa051690.63970957
95cAMP signaling pathway_Homo sapiens_hsa040240.63687097
96Small cell lung cancer_Homo sapiens_hsa052220.63234799
97MAPK signaling pathway_Homo sapiens_hsa040100.61462586
98Herpes simplex infection_Homo sapiens_hsa051680.60700933
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59937739
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58098839
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57851699
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57532848
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.57422176
104Ovarian steroidogenesis_Homo sapiens_hsa049130.57165347
105Pertussis_Homo sapiens_hsa051330.57055239
106Allograft rejection_Homo sapiens_hsa053300.57015433
107Glycerolipid metabolism_Homo sapiens_hsa005610.56896527
108Histidine metabolism_Homo sapiens_hsa003400.56670671
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56022603
110Tuberculosis_Homo sapiens_hsa051520.55950631
111Starch and sucrose metabolism_Homo sapiens_hsa005000.55748494
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53958244
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53713437
114Renin secretion_Homo sapiens_hsa049240.53637203
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52472393
116Long-term potentiation_Homo sapiens_hsa047200.52421236
117Pancreatic secretion_Homo sapiens_hsa049720.52043189
118Peroxisome_Homo sapiens_hsa041460.51409456
119Proteoglycans in cancer_Homo sapiens_hsa052050.51403826
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50987580
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.50653470
122Estrogen signaling pathway_Homo sapiens_hsa049150.50154198
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.48759725
124MicroRNAs in cancer_Homo sapiens_hsa052060.48321025
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48225945
126Viral myocarditis_Homo sapiens_hsa054160.47922380
127Amoebiasis_Homo sapiens_hsa051460.47766970
128Malaria_Homo sapiens_hsa051440.47658417
129HIF-1 signaling pathway_Homo sapiens_hsa040660.47577313
130Phenylalanine metabolism_Homo sapiens_hsa003600.47141358
131Insulin signaling pathway_Homo sapiens_hsa049100.46837238
132Mineral absorption_Homo sapiens_hsa049780.46550693
133Rheumatoid arthritis_Homo sapiens_hsa053230.45124208
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45103681
135Endocytosis_Homo sapiens_hsa041440.45054348
136GnRH signaling pathway_Homo sapiens_hsa049120.44723957
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44304382
138Focal adhesion_Homo sapiens_hsa045100.43679664
139Regulation of autophagy_Homo sapiens_hsa041400.41517058

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