ATXN7L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)5.03282276
2actin-myosin filament sliding (GO:0033275)5.02146045
3muscle filament sliding (GO:0030049)5.02146045
4skeletal muscle contraction (GO:0003009)4.88761908
5regulation of skeletal muscle contraction (GO:0014819)4.75595137
6creatine metabolic process (GO:0006600)4.53175843
7pre-miRNA processing (GO:0031054)4.46133924
8establishment of mitochondrion localization (GO:0051654)4.33260850
9negative regulation of erythrocyte differentiation (GO:0045647)4.25045612
10mitochondrion transport along microtubule (GO:0047497)4.06308731
11establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.06308731
123-UTR-mediated mRNA stabilization (GO:0070935)3.98311896
13positive regulation of myotube differentiation (GO:0010831)3.92776122
14peptidyl-arginine omega-N-methylation (GO:0035247)3.87653015
15negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.80823529
16negative regulation of cell size (GO:0045792)3.75800389
17peptidyl-arginine N-methylation (GO:0035246)3.71375376
18peptidyl-arginine methylation (GO:0018216)3.71375376
19regulation of NFAT protein import into nucleus (GO:0051532)3.69400118
20actin-mediated cell contraction (GO:0070252)3.65704088
21response to inactivity (GO:0014854)3.57899311
22protein-DNA complex disassembly (GO:0032986)3.43365775
23nucleosome disassembly (GO:0006337)3.43365775
24DNA unwinding involved in DNA replication (GO:0006268)3.41864395
25negative regulation of mRNA processing (GO:0050686)3.40784694
26striated muscle contraction (GO:0006941)3.35723854
27negative regulation of necroptotic process (GO:0060546)3.34968949
28positive regulation of RNA splicing (GO:0033120)3.34433259
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.33679885
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.33145176
31histone H4 deacetylation (GO:0070933)3.32396096
32histone H3 deacetylation (GO:0070932)3.30483121
33negative regulation of DNA-templated transcription, elongation (GO:0032785)3.28113216
34protein insertion into membrane (GO:0051205)3.26582772
35negative regulation of RNA splicing (GO:0033119)3.24935333
36mitochondrial fusion (GO:0008053)3.16366402
37positive regulation of protein sumoylation (GO:0033235)3.16068203
38peptidyl-lysine dimethylation (GO:0018027)3.13524114
39positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.11363870
40histone H3 acetylation (GO:0043966)3.10625568
41negative regulation of mRNA metabolic process (GO:1903312)3.07247930
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.07170823
43mRNA splice site selection (GO:0006376)3.05377046
44histone arginine methylation (GO:0034969)3.03763676
45locomotory exploration behavior (GO:0035641)3.02285102
46positive regulation of synapse maturation (GO:0090129)3.01649893
47skeletal muscle fiber development (GO:0048741)2.99647083
48cell migration in hindbrain (GO:0021535)2.97393791
49synaptic vesicle maturation (GO:0016188)2.96611484
50histone H4-K5 acetylation (GO:0043981)2.94930245
51histone H4-K8 acetylation (GO:0043982)2.94930245
52synaptic vesicle docking involved in exocytosis (GO:0016081)2.94329093
53intracellular estrogen receptor signaling pathway (GO:0030520)2.92973235
54negative regulation of histone methylation (GO:0031061)2.91561327
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88780352
56paraxial mesoderm development (GO:0048339)2.87420040
57regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87178108
58response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.81579731
59positive regulation of gene expression, epigenetic (GO:0045815)2.81057477
60regulation of relaxation of muscle (GO:1901077)2.80635460
61mitochondrion localization (GO:0051646)2.80375589
62adherens junction assembly (GO:0034333)2.80017795
63nucleotide salvage (GO:0043173)2.79487233
64V(D)J recombination (GO:0033151)2.79158969
65histone H4-K16 acetylation (GO:0043984)2.79127389
66negative regulation of necrotic cell death (GO:0060547)2.77850283
67regulation of synapse maturation (GO:0090128)2.77823344
68histone H4 acetylation (GO:0043967)2.76584674
69histone H2A acetylation (GO:0043968)2.76162684
70ubiquinone biosynthetic process (GO:0006744)2.76063097
71skeletal muscle cell differentiation (GO:0035914)2.75634189
72layer formation in cerebral cortex (GO:0021819)2.75454148
73negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74968915
74negative regulation of microtubule polymerization (GO:0031115)2.73076679
75sarcomere organization (GO:0045214)2.72353350
76dendritic spine morphogenesis (GO:0060997)2.72057933
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.71011722
78actin filament-based movement (GO:0030048)2.70809970
79head development (GO:0060322)2.68656312
80histone H3-K9 demethylation (GO:0033169)2.68191007
81establishment of nucleus localization (GO:0040023)2.66773152
82regulation of chromatin binding (GO:0035561)2.65641303
83regulation of myotube differentiation (GO:0010830)2.64705303
84poly(A)+ mRNA export from nucleus (GO:0016973)2.64195627
85receptor recycling (GO:0001881)2.64033379
86myotube cell development (GO:0014904)2.63842786
87vocalization behavior (GO:0071625)2.62064778
88RNA stabilization (GO:0043489)2.60370439
89mRNA stabilization (GO:0048255)2.60370439
90snRNA metabolic process (GO:0016073)2.59737279
91ubiquinone metabolic process (GO:0006743)2.58664103
92dosage compensation (GO:0007549)2.58183353
93cranial nerve morphogenesis (GO:0021602)2.56630839
94myofibril assembly (GO:0030239)2.55342831
95cerebral cortex neuron differentiation (GO:0021895)2.55159400
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.54108710
97regulation of DNA damage checkpoint (GO:2000001)2.53819704
98histone H4-K12 acetylation (GO:0043983)2.53666753
99mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.52725940
100regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52454808
101DNA duplex unwinding (GO:0032508)2.52388430
102positive regulation of mitochondrial fission (GO:0090141)2.51934897
103positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.50559105
104DNA geometric change (GO:0032392)2.50340654
105alternative mRNA splicing, via spliceosome (GO:0000380)2.49370780
106respiratory system process (GO:0003016)2.49230041
107establishment of integrated proviral latency (GO:0075713)2.49208353
108focal adhesion assembly (GO:0048041)2.48772430
109cell-substrate adherens junction assembly (GO:0007045)2.48772430
110glucocorticoid receptor signaling pathway (GO:0042921)2.47759472
111snRNA processing (GO:0016180)2.47697667
112regulation of glutamate receptor signaling pathway (GO:1900449)2.45765587
113regulation of posttranscriptional gene silencing (GO:0060147)2.45548828
114regulation of gene silencing by miRNA (GO:0060964)2.45548828
115regulation of gene silencing by RNA (GO:0060966)2.45548828
116snRNA transcription (GO:0009301)2.43498209
117gluconeogenesis (GO:0006094)2.42476935
118histone demethylation (GO:0016577)2.42372584
119negative regulation of gene expression, epigenetic (GO:0045814)2.40546653
120negative regulation of skeletal muscle tissue development (GO:0048642)2.40108009
121histone lysine demethylation (GO:0070076)2.40038047
122negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.39343832
123regulation of necroptotic process (GO:0060544)2.39311707
124activation of MAPKKK activity (GO:0000185)2.39260778
125sodium ion export (GO:0071436)2.38521910
126glial cell proliferation (GO:0014009)2.37807001
127response to muramyl dipeptide (GO:0032495)2.37586350
128histone deacetylation (GO:0016575)2.37218825
129histone H3-K4 methylation (GO:0051568)2.36927992
130synaptic vesicle exocytosis (GO:0016079)2.36667600
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.35860801
132mRNA splicing, via spliceosome (GO:0000398)2.35860801
133protein demethylation (GO:0006482)2.35665465
134protein dealkylation (GO:0008214)2.35665465
135cellular hyperosmotic response (GO:0071474)2.35583509
136central nervous system projection neuron axonogenesis (GO:0021952)2.35357612
137mitotic sister chromatid cohesion (GO:0007064)2.34917171
138muscle cell fate commitment (GO:0042693)2.34849952
139positive regulation of cell cycle checkpoint (GO:1901978)2.34444448
140regulation of mRNA splicing, via spliceosome (GO:0048024)2.33794537
141axonal fasciculation (GO:0007413)2.32303581
142heterochromatin organization (GO:0070828)2.31723602
143peptidyl-arginine modification (GO:0018195)2.31198866
144RNA splicing, via transesterification reactions (GO:0000375)2.30083902
145regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.29728192
146internal peptidyl-lysine acetylation (GO:0018393)2.29366300
147histone methylation (GO:0016571)2.29271457
148cerebellar Purkinje cell differentiation (GO:0021702)2.28936167
149histone H3-K4 trimethylation (GO:0080182)2.28767659
150gene silencing (GO:0016458)2.28360637
151chromatin silencing (GO:0006342)2.27962271
152positive regulation of dendritic spine morphogenesis (GO:0061003)2.26712683
153RNA localization (GO:0006403)2.25874876
154regulation of somitogenesis (GO:0014807)2.24371769
155mitotic G1 DNA damage checkpoint (GO:0031571)2.23930930
156negative regulation of cell killing (GO:0031342)2.23790407
157negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.23790407
158histone acetylation (GO:0016573)2.23550271
159histone lysine methylation (GO:0034968)2.22889586
160gene silencing by RNA (GO:0031047)2.22525938
161protein localization to synapse (GO:0035418)2.21486618
162stress granule assembly (GO:0034063)2.21046180
163regulation of histone H3-K9 methylation (GO:0051570)2.20882492
164regulation of synapse structural plasticity (GO:0051823)2.20485581
165regulation of translational fidelity (GO:0006450)2.20462564
166regulation of neuronal synaptic plasticity (GO:0048168)2.19921600
167peptidyl-lysine acetylation (GO:0018394)2.19721473
168negative regulation of histone acetylation (GO:0035067)2.16715917
169regulation of mRNA stability (GO:0043488)2.16697660
170termination of RNA polymerase II transcription (GO:0006369)2.15748386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.57160841
2MYC_22102868_ChIP-Seq_BL_Human3.33073380
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.21786709
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.10117244
5EZH2_22144423_ChIP-Seq_EOC_Human3.08372626
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.97533293
7* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.65512494
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.56231811
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.31936754
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.29258467
11ZFP281_27345836_Chip-Seq_ESCs_Mouse2.27420152
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.21217094
13* KDM2B_26808549_Chip-Seq_DND41_Human2.19702516
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18350705
15* CIITA_25753668_ChIP-Seq_RAJI_Human2.17509985
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13824979
17VDR_21846776_ChIP-Seq_THP-1_Human2.09018410
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01559244
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.99393213
20* TCF7_22412390_ChIP-Seq_EML_Mouse1.95293595
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93382284
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89324104
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86317352
24TET1_21451524_ChIP-Seq_MESCs_Mouse1.85549694
25* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.84299191
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76743267
27KDM2B_26808549_Chip-Seq_K562_Human1.76320903
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74345091
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73720413
30DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72298508
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70265302
32* XRN2_22483619_ChIP-Seq_HELA_Human1.69740678
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.69718866
34SA1_27219007_Chip-Seq_ERYTHROID_Human1.68946775
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.68469325
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68132767
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.67054179
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66324390
39* MAF_26560356_Chip-Seq_TH2_Human1.64316767
40MAF_26560356_Chip-Seq_TH1_Human1.64187008
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62258620
42* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.62206906
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60141006
44* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59560791
45ZNF263_19887448_ChIP-Seq_K562_Human1.57278400
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54862907
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.54267258
48DROSHA_22980978_ChIP-Seq_HELA_Human1.49568799
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47946227
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47886971
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46642837
52MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.45479711
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44997510
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43652067
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43162452
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41797140
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.41740065
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40231838
59CTCF_26484167_Chip-Seq_Bcells_Mouse1.40137957
60LXR_22292898_ChIP-Seq_THP-1_Human1.39322394
61* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37857322
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37684893
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37223002
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36774756
65SMC4_20622854_ChIP-Seq_HELA_Human1.33179517
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.32970727
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32509099
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31900932
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31281235
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30304120
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29736312
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29320408
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28831375
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28812614
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27655247
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27655247
77CTCF_27219007_Chip-Seq_Bcells_Human1.27151990
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.27050257
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26157477
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.24747959
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24317317
82CTCF_21964334_Chip-Seq_Bcells_Human1.24164482
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24084272
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23587233
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22914793
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22053202
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21489712
88UTX_26944678_Chip-Seq_JUKART_Human1.20966714
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.18787204
90BCOR_27268052_Chip-Seq_Bcells_Human1.18105263
91CREB1_26743006_Chip-Seq_LNCaP_Human1.17942699
92GABP_19822575_ChIP-Seq_HepG2_Human1.17824260
93REST_21632747_ChIP-Seq_MESCs_Mouse1.17755277
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.17677648
95ETS1_20019798_ChIP-Seq_JURKAT_Human1.17670908
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17211390
97BCL6_27268052_Chip-Seq_Bcells_Human1.16742197
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16432119
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.16161793
100PHF8_20622854_ChIP-Seq_HELA_Human1.16136908
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15833826
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15791651
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15094523
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15014060
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14994738
106DCP1A_22483619_ChIP-Seq_HELA_Human1.14234844
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13551835
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13225863
109SA1_27219007_Chip-Seq_Bcells_Human1.13070484
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12791037
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.12756833
112NCOR1_26117541_ChIP-Seq_K562_Human1.12600582
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12322930
114SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11589632
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11233389
116* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11011579
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09082744
118* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08086391
119NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08002002
120P68_20966046_ChIP-Seq_HELA_Human1.07733086
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06958961
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06288337
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05828826
124CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04262568
125EZH2_27304074_Chip-Seq_ESCs_Mouse1.03381825
126* RARB_24833708_ChIP-Seq_LIVER_Mouse1.03291736
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02719144
128E2F1_21310950_ChIP-Seq_MCF-7_Human1.02703893
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02607178
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02541106
131* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02092016
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01762946
133EZH2_27294783_Chip-Seq_ESCs_Mouse1.01366872
134GATA1_26923725_Chip-Seq_HPCs_Mouse1.01245628
135* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01098157
136* KDM5A_27292631_Chip-Seq_BREAST_Human1.00821507
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00402896
138TTF2_22483619_ChIP-Seq_HELA_Human1.00235939
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00208103
140SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99792368
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.98674804
142* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98123767
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95543775
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.95241726
145POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95202391
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95000902
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94089730
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.93206965
149MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92518474
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92280326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.65349337
2MP0004145_abnormal_muscle_electrophysio4.50766112
3MP0000751_myopathy4.48257163
4MP0002822_catalepsy4.39812181
5MP0003646_muscle_fatigue3.13945455
6MP0005451_abnormal_body_composition3.03615294
7MP0000759_abnormal_skeletal_muscle2.76488361
8MP0000750_abnormal_muscle_regeneration2.69269671
9MP0008877_abnormal_DNA_methylation2.63532900
10MP0000749_muscle_degeneration2.61765473
11MP0000747_muscle_weakness2.55936349
12MP0008961_abnormal_basal_metabolism2.53228506
13MP0002106_abnormal_muscle_physiology2.46528613
14MP0002332_abnormal_exercise_endurance2.29160958
15MP0003635_abnormal_synaptic_transmissio2.27814932
16MP0003787_abnormal_imprinting2.25324423
17MP0002653_abnormal_ependyma_morphology2.20074983
18MP0005423_abnormal_somatic_nervous2.19422503
19MP0005369_muscle_phenotype2.14863695
20MP0004087_abnormal_muscle_fiber2.10650447
21MP0003123_paternal_imprinting2.07643242
22MP0008260_abnormal_autophagy2.00385701
23MP0003880_abnormal_central_pattern1.95741508
24MP0000778_abnormal_nervous_system1.94844654
25MP0006292_abnormal_olfactory_placode1.92087412
26MP0003121_genomic_imprinting1.91369833
27MP0002063_abnormal_learning/memory/cond1.86053914
28MP0010094_abnormal_chromosome_stability1.84271191
29MP0003122_maternal_imprinting1.76500781
30MP0004233_abnormal_muscle_weight1.66512938
31MP0001849_ear_inflammation1.64313627
32MP0003111_abnormal_nucleus_morphology1.63697200
33MP0004036_abnormal_muscle_relaxation1.63203429
34MP0003942_abnormal_urinary_system1.61764292
35MP0003221_abnormal_cardiomyocyte_apopto1.60119416
36MP0002269_muscular_atrophy1.59847078
37MP0003861_abnormal_nervous_system1.58963339
38MP0003890_abnormal_embryonic-extraembry1.58749770
39MP0005076_abnormal_cell_differentiation1.58749696
40MP0010030_abnormal_orbit_morphology1.58089304
41MP0002184_abnormal_innervation1.56654048
42MP0003119_abnormal_digestive_system1.56428629
43MP0000955_abnormal_spinal_cord1.51971399
44MP0004811_abnormal_neuron_physiology1.49788127
45MP0000678_abnormal_parathyroid_gland1.48968968
46MP0004510_myositis1.47505054
47MP0003283_abnormal_digestive_organ1.44268862
48MP0001529_abnormal_vocalization1.43106764
49MP0003077_abnormal_cell_cycle1.42185577
50MP0002108_abnormal_muscle_morphology1.40709831
51MP0004133_heterotaxia1.40598019
52MP0004130_abnormal_muscle_cell1.38714108
53MP0005499_abnormal_olfactory_system1.38469790
54MP0005394_taste/olfaction_phenotype1.38469790
55MP0004270_analgesia1.36772947
56MP0000049_abnormal_middle_ear1.35692060
57MP0004858_abnormal_nervous_system1.35462476
58MP0002152_abnormal_brain_morphology1.34879900
59MP0002163_abnormal_gland_morphology1.33965850
60MP0002084_abnormal_developmental_patter1.33542301
61MP0002085_abnormal_embryonic_tissue1.32464358
62MP0009745_abnormal_behavioral_response1.32099680
63MP0000534_abnormal_ureter_morphology1.31401029
64MP0008569_lethality_at_weaning1.31068122
65MP0000350_abnormal_cell_proliferation1.29985526
66MP0002064_seizures1.29847326
67MP0000003_abnormal_adipose_tissue1.29777276
68MP0000569_abnormal_digit_pigmentation1.28467237
69MP0003763_abnormal_thymus_physiology1.27571789
70MP0002572_abnormal_emotion/affect_behav1.27245510
71MP0003693_abnormal_embryo_hatching1.26987047
72MP0001346_abnormal_lacrimal_gland1.25452108
73MP0003115_abnormal_respiratory_system1.25349963
74MP0001730_embryonic_growth_arrest1.24752666
75MP0003938_abnormal_ear_development1.23794042
76MP0000631_abnormal_neuroendocrine_gland1.23724169
77MP0004197_abnormal_fetal_growth/weight/1.23306535
78MP0003656_abnormal_erythrocyte_physiolo1.21516710
79MP0002234_abnormal_pharynx_morphology1.21364747
80MP0001348_abnormal_lacrimal_gland1.21197622
81MP0001968_abnormal_touch/_nociception1.19793750
82MP0000703_abnormal_thymus_morphology1.17214904
83MP0002751_abnormal_autonomic_nervous1.13044552
84MP0001697_abnormal_embryo_size1.12172432
85MP0002932_abnormal_joint_morphology1.12001057
86MP0008007_abnormal_cellular_replicative1.09469649
87MP0000013_abnormal_adipose_tissue1.09195505
88MP0002882_abnormal_neuron_morphology1.06981899
89MP0009046_muscle_twitch1.06955412
90MP0002089_abnormal_postnatal_growth/wei1.06241208
91MP0000537_abnormal_urethra_morphology1.05429123
92MP0003436_decreased_susceptibility_to1.05192121
93MP0002114_abnormal_axial_skeleton1.05130292
94MP0005620_abnormal_muscle_contractility1.04720337
95MP0004885_abnormal_endolymph1.03836143
96MP0010630_abnormal_cardiac_muscle1.02844068
97MP0002081_perinatal_lethality1.02752649
98MP0005375_adipose_tissue_phenotype1.02361798
99MP0004957_abnormal_blastocyst_morpholog1.02120157
100MP0002557_abnormal_social/conspecific_i1.02004919
101MP0008058_abnormal_DNA_repair1.01717076
102MP0008057_abnormal_DNA_replication1.01590403
103MP0010352_gastrointestinal_tract_polyps1.00997463
104MP0008789_abnormal_olfactory_epithelium0.99195711
105MP0006035_abnormal_mitochondrial_morpho0.98942484
106MP0000428_abnormal_craniofacial_morphol0.98550175
107MP0005330_cardiomyopathy0.97781165
108MP0002116_abnormal_craniofacial_bone0.97382102
109MP0002249_abnormal_larynx_morphology0.97178935
110MP0009672_abnormal_birth_weight0.91037374
111MP0001486_abnormal_startle_reflex0.90529909
112MP0008995_early_reproductive_senescence0.90378193
113MP0001270_distended_abdomen0.89404745
114MP0001672_abnormal_embryogenesis/_devel0.89268700
115MP0005380_embryogenesis_phenotype0.89268700
116MP0006036_abnormal_mitochondrial_physio0.88658072
117MP0003935_abnormal_craniofacial_develop0.88170019
118MP0000733_abnormal_muscle_development0.87752368
119MP0002080_prenatal_lethality0.87251789
120MP0004808_abnormal_hematopoietic_stem0.87012119
121MP0002736_abnormal_nociception_after0.86600574
122MP0008770_decreased_survivor_rate0.86541993
123MP0009278_abnormal_bone_marrow0.86495471
124MP0010769_abnormal_survival0.84300251
125MP0010768_mortality/aging0.83648108
126MP0005623_abnormal_meninges_morphology0.83130214
127MP0002066_abnormal_motor_capabilities/c0.82442221
128MP0003984_embryonic_growth_retardation0.81696750
129MP0002396_abnormal_hematopoietic_system0.81400435
130MP0002734_abnormal_mechanical_nocicepti0.81024374
131MP0005645_abnormal_hypothalamus_physiol0.80702458
132MP0001293_anophthalmia0.80388124
133MP0002272_abnormal_nervous_system0.80206345
134MP0003137_abnormal_impulse_conducting0.79668493
135MP0010770_preweaning_lethality0.79642743
136MP0002082_postnatal_lethality0.79642743
137MP0009703_decreased_birth_body0.79327075
138MP0002088_abnormal_embryonic_growth/wei0.78017621
139MP0002067_abnormal_sensory_capabilities0.77909877
140MP0003755_abnormal_palate_morphology0.77568665
141MP0005266_abnormal_metabolism0.77559477
142MP0002127_abnormal_cardiovascular_syste0.73559509
143MP0005666_abnormal_adipose_tissue0.73040196
144MP0003948_abnormal_gas_homeostasis0.72157706
145MP0004185_abnormal_adipocyte_glucose0.70184447
146MP0005397_hematopoietic_system_phenotyp0.69891576
147MP0001545_abnormal_hematopoietic_system0.69891576
148MP0009333_abnormal_splenocyte_physiolog0.68963776
149MP0006138_congestive_heart_failure0.67790526
150MP0002102_abnormal_ear_morphology0.67140798
151MP0000313_abnormal_cell_death0.66860225
152MP0006276_abnormal_autonomic_nervous0.65109902
153MP0004142_abnormal_muscle_tone0.62951278
154MP0003385_abnormal_body_wall0.61480398
155MP0008932_abnormal_embryonic_tissue0.61093654
156MP0002398_abnormal_bone_marrow0.60564885
157MP0005083_abnormal_biliary_tract0.59880876

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.86042133
2Nemaline bodies (HP:0003798)6.71646760
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.54336304
4Exercise-induced myalgia (HP:0003738)6.28127131
5Myopathic facies (HP:0002058)5.48664909
6Type 1 muscle fiber predominance (HP:0003803)5.37586154
7Round ear (HP:0100830)5.13770683
8Exercise-induced muscle cramps (HP:0003710)5.02977204
9Distal arthrogryposis (HP:0005684)4.94722164
10Calcaneovalgus deformity (HP:0001848)4.57463314
11Ulnar deviation of the wrist (HP:0003049)4.42042621
12Deformed tarsal bones (HP:0008119)4.15530148
13Hyperacusis (HP:0010780)4.03934373
14Renal duplication (HP:0000075)3.94400120
15Muscle hypertrophy of the lower extremities (HP:0008968)3.71091819
16Centrally nucleated skeletal muscle fibers (HP:0003687)3.63609687
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.56966331
18Short 4th metacarpal (HP:0010044)3.56966331
19Elfin facies (HP:0004428)3.51235625
20Rhabdomyolysis (HP:0003201)3.41248066
21Progressive muscle weakness (HP:0003323)3.40190666
22Insomnia (HP:0100785)3.33576129
23Myotonia (HP:0002486)3.33159804
24Overriding aorta (HP:0002623)3.30142889
25Abnormality of the lower motor neuron (HP:0002366)3.22788676
26Increased nuchal translucency (HP:0010880)3.22044901
27EMG: myopathic abnormalities (HP:0003458)3.21898239
28Muscle stiffness (HP:0003552)3.21004016
29Myoglobinuria (HP:0002913)3.18687698
30Distal lower limb amyotrophy (HP:0008944)3.16215663
31Abnormality of the calcaneus (HP:0008364)3.15112874
32Peripheral hypomyelination (HP:0007182)3.01228339
33Increased connective tissue (HP:0009025)2.95203575
34Abnormality of skeletal muscle fiber size (HP:0012084)2.93376299
35Pointed chin (HP:0000307)2.91075538
36Ependymoma (HP:0002888)2.90407279
37Subaortic stenosis (HP:0001682)2.86200882
38Abnormality of the left ventricular outflow tract (HP:0011103)2.86200882
39Rimmed vacuoles (HP:0003805)2.84271132
40Calf muscle hypertrophy (HP:0008981)2.84024890
41Ragged-red muscle fibers (HP:0003200)2.78470896
42Neoplasm of the heart (HP:0100544)2.75462597
43Myokymia (HP:0002411)2.75092108
44Difficulty climbing stairs (HP:0003551)2.74315174
45Renovascular hypertension (HP:0100817)2.73103797
46Absent phalangeal crease (HP:0006109)2.72682905
47EMG: neuropathic changes (HP:0003445)2.71813889
48Abnormality of the intervertebral disk (HP:0005108)2.68086892
49Neck muscle weakness (HP:0000467)2.66816918
50Anomalous pulmonary venous return (HP:0010772)2.61763895
51Increased variability in muscle fiber diameter (HP:0003557)2.61587263
52Abnormality of the astrocytes (HP:0100707)2.56842844
53Astrocytoma (HP:0009592)2.56842844
54Trigonocephaly (HP:0000243)2.56228692
55Mildly elevated creatine phosphokinase (HP:0008180)2.51611925
56Medulloblastoma (HP:0002885)2.50432237
57Flat cornea (HP:0007720)2.49918684
58Muscle fiber splitting (HP:0003555)2.44221365
59Distal lower limb muscle weakness (HP:0009053)2.43725455
60Malignant hyperthermia (HP:0002047)2.41584310
61Obsessive-compulsive behavior (HP:0000722)2.41122426
62Lower limb amyotrophy (HP:0007210)2.40787978
63Bulbar palsy (HP:0001283)2.38396598
64Abnormality of the 4th metacarpal (HP:0010012)2.36148014
65Abnormality of the fingertips (HP:0001211)2.35191459
66Reticulocytosis (HP:0001923)2.33244060
67Fetal akinesia sequence (HP:0001989)2.32753106
68Difficulty running (HP:0009046)2.32284552
69Abnormality of the calf musculature (HP:0001430)2.30612778
70Ankle clonus (HP:0011448)2.30103783
71Frequent falls (HP:0002359)2.28026790
72Annular pancreas (HP:0001734)2.25917758
73Abnormality of the pulmonary veins (HP:0011718)2.25772292
74Focal seizures (HP:0007359)2.25479466
75Metatarsus adductus (HP:0001840)2.24486823
76Spina bifida occulta (HP:0003298)2.23006806
77Bowel diverticulosis (HP:0005222)2.22641100
78Abnormality of the foot musculature (HP:0001436)2.21354637
79Rib fusion (HP:0000902)2.18069222
80Acute lymphatic leukemia (HP:0006721)2.17176602
81Neoplasm of striated muscle (HP:0009728)2.14217300
82Abnormal finger flexion creases (HP:0006143)2.14091996
83Abnormal number of incisors (HP:0011064)2.13695352
84Abnormality of the labia minora (HP:0012880)2.08047763
85Sacral dimple (HP:0000960)2.07779533
86Impaired smooth pursuit (HP:0007772)2.07456193
87Long eyelashes (HP:0000527)2.07439147
88Focal motor seizures (HP:0011153)2.07397994
89Skin tags (HP:0010609)2.06977951
90Foot dorsiflexor weakness (HP:0009027)2.06597916
91Shoulder girdle muscle weakness (HP:0003547)2.05960293
92Neoplasm of the oral cavity (HP:0100649)2.05143270
93Sparse lateral eyebrow (HP:0005338)2.03764912
94Megalocornea (HP:0000485)2.02639055
95Cholecystitis (HP:0001082)2.02521563
96Abnormal gallbladder physiology (HP:0012438)2.02521563
97Long palpebral fissure (HP:0000637)2.01451786
98Impaired vibration sensation in the lower limbs (HP:0002166)1.95257300
99Slender build (HP:0001533)1.94305665
100Vertebral fusion (HP:0002948)1.94297186
101Abnormality of the shoulder girdle musculature (HP:0001435)1.94018474
102Supernumerary ribs (HP:0005815)1.92917113
103Glioma (HP:0009733)1.92641311
104Pseudobulbar signs (HP:0002200)1.91610623
105Abnormality of the aortic arch (HP:0012303)1.91543212
106Hypoplasia of the brainstem (HP:0002365)1.90098094
107Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90098094
108Scapular winging (HP:0003691)1.89010464
109Abnormality of the diencephalon (HP:0010662)1.86367601
110Congenital hip dislocation (HP:0001374)1.86316974
111Congenital diaphragmatic hernia (HP:0000776)1.86136326
112Volvulus (HP:0002580)1.85851855
113Preauricular skin tag (HP:0000384)1.85451965
114Fatigue (HP:0012378)1.84610894
115Generalized muscle weakness (HP:0003324)1.83771359
116Arnold-Chiari malformation (HP:0002308)1.83540271
117Achilles tendon contracture (HP:0001771)1.82481323
118Abnormality of ocular smooth pursuit (HP:0000617)1.81691940
119Vertebral arch anomaly (HP:0008438)1.81539619
120Shallow orbits (HP:0000586)1.81291172
121Intestinal fistula (HP:0100819)1.80999333
122Hyporeflexia of lower limbs (HP:0002600)1.80465403
123Abnormality of the antihelix (HP:0009738)1.79390230
124Hemivertebrae (HP:0002937)1.79364840
125Areflexia of lower limbs (HP:0002522)1.78877518
126Epileptic encephalopathy (HP:0200134)1.78806268
127Limb-girdle muscle atrophy (HP:0003797)1.77353889
128Aplasia of the musculature (HP:0100854)1.76867601
129Asymmetric septal hypertrophy (HP:0001670)1.76854794
130Cholelithiasis (HP:0001081)1.76599447
131Visual hallucinations (HP:0002367)1.75777741
132Shawl scrotum (HP:0000049)1.74631042
133Steppage gait (HP:0003376)1.74529179
134Generalized hypotonia (HP:0001290)1.73415376
135Megalencephaly (HP:0001355)1.73286838
136Supernumerary bones of the axial skeleton (HP:0009144)1.73258356
137Stridor (HP:0010307)1.73102044
138Ankyloglossia (HP:0010296)1.73054410
139Amyotrophic lateral sclerosis (HP:0007354)1.72077248
140Pelvic girdle muscle weakness (HP:0003749)1.71126544
141Wrist flexion contracture (HP:0001239)1.70248137
142Urinary urgency (HP:0000012)1.70060268
143Acute hepatic failure (HP:0006554)1.70036918
144Cortical dysplasia (HP:0002539)1.69921370
145Hepatoblastoma (HP:0002884)1.69035916
146Retinal dysplasia (HP:0007973)1.68956608
147Broad palm (HP:0001169)1.68181971
148Amblyopia (HP:0000646)1.67791346
149Abnormality of the columella (HP:0009929)1.67239983
150Proximal placement of thumb (HP:0009623)1.67127378
151Waddling gait (HP:0002515)1.66528813
152Hammertoe (HP:0001765)1.65566534
153Thin ribs (HP:0000883)1.65550270
154Anteriorly placed anus (HP:0001545)1.64839963
155Abnormality of lateral ventricle (HP:0030047)1.63920571
156Attention deficit hyperactivity disorder (HP:0007018)1.63301983
157Adducted thumb (HP:0001181)1.62468582
158Colon cancer (HP:0003003)1.62400965
159Optic nerve coloboma (HP:0000588)1.61973288
160Leiomyosarcoma (HP:0100243)1.61489017
161Uterine leiomyosarcoma (HP:0002891)1.61489017
162Trismus (HP:0000211)1.60616020
163Bilateral microphthalmos (HP:0007633)1.60440101
164Progressive external ophthalmoplegia (HP:0000590)1.60215902
165Wide mouth (HP:0000154)1.60117719
166Dysmetric saccades (HP:0000641)1.59435988
167Limb-girdle muscle weakness (HP:0003325)1.59286921
168Bowel incontinence (HP:0002607)1.58958504
169Muscle fiber atrophy (HP:0100295)1.58336243
170Spastic gait (HP:0002064)1.58323073
171Bladder diverticulum (HP:0000015)1.57905393
172Deep palmar crease (HP:0006191)1.57260548
173Abnormality of the hip-girdle musculature (HP:0001445)1.56931408
174Abnormality of the musculature of the pelvis (HP:0001469)1.56931408
175Macroorchidism (HP:0000053)1.56033396
176Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.54197850
177Easy fatigability (HP:0003388)1.53994571
178Autism (HP:0000717)1.53837206
179Malignant gastrointestinal tract tumors (HP:0006749)1.52621764
180Gastrointestinal carcinoma (HP:0002672)1.52621764
181Urethral obstruction (HP:0000796)1.52613633
182Short phalanx of the thumb (HP:0009660)1.52325356
183High anterior hairline (HP:0009890)1.52239551
184Deviation of the thumb (HP:0009603)1.51721442
185Abnormality of the metopic suture (HP:0005556)1.50953622
186Large eyes (HP:0001090)1.50883210
187Basal cell carcinoma (HP:0002671)1.50284566
188Abnormality of chromosome segregation (HP:0002916)1.49996166
189Obstructive sleep apnea (HP:0002870)1.48757606
190Hypercalciuria (HP:0002150)1.47994236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.26693355
2MAP3K103.52291982
3OBSCN3.36154955
4TTN2.98146376
5NTRK32.58129691
6BRD42.53009993
7SIK22.49566463
8EEF2K2.29957516
9MARK12.14532822
10SIK12.14057806
11MAP3K42.12704013
12TAOK22.11164510
13PHKG12.10616376
14PHKG22.10616376
15TYRO32.09577800
16NTRK21.92029176
17EPHA41.88514327
18ICK1.87522987
19CDC71.86892213
20GRK61.81686444
21MAP3K91.79497987
22SIK31.63496763
23KSR11.60234100
24NME21.56710431
25UHMK11.55017795
26DAPK11.53281678
27TRIB31.48872732
28PRKD31.47299224
29PASK1.44734493
30WNK31.44119915
31PKN21.42157633
32MAP3K131.42043856
33ALK1.38683822
34MINK11.33843921
35MAP2K31.29860044
36SMG11.27623571
37EPHB11.25859200
38PIM21.25624128
39FGFR21.25538681
40RAF11.24524863
41PNCK1.23802715
42MARK21.18848917
43MAPK111.17195786
44MAPK121.16798955
45CDK191.13993183
46PAK61.13907597
47DAPK21.12467760
48MAP4K11.11602533
49FGFR11.08402997
50MAP3K71.05422957
51TESK11.04795830
52CCNB11.03832371
53NME11.02686383
54TAOK10.99425050
55IRAK30.99255111
56MAP3K60.98809783
57DYRK1A0.97789878
58PIK3CG0.94249061
59BMX0.88088938
60MTOR0.85822579
61ATR0.85172145
62CAMK1G0.85141093
63CDK50.83990245
64PAK40.83267339
65CHEK10.83228349
66CDK70.83054905
67MAPK70.81597830
68STK110.81480907
69RPS6KC10.81304431
70RPS6KL10.81304431
71NEK20.78061324
72CDK20.77095956
73ITK0.76427755
74MAPK40.75938867
75MAP3K140.73670019
76BUB10.73430986
77PDGFRA0.71874300
78RET0.70887847
79CAMK40.69523471
80HIPK20.69006650
81PRPF4B0.68885771
82MAP2K70.67153729
83LIMK10.67097999
84WNK40.65143575
85TESK20.64972744
86CDK180.63333929
87FES0.63247892
88RPS6KA60.61104053
89CDC42BPA0.60996171
90CAMK2G0.59803794
91CDK150.59700218
92WNK10.59165617
93AURKA0.59072363
94MAPK90.59066807
95KSR20.58729466
96MAPK130.58378083
97CDK11A0.58239684
98CSNK1A1L0.57274061
99MUSK0.56843208
100MAPK150.56341538
101MAPK80.56141600
102GSK3B0.55974206
103PKN10.55304068
104CDK10.54617033
105CSNK1G30.54048428
106TLK10.53513003
107PRKAA10.53448798
108PRKDC0.53148392
109RPS6KA20.53070363
110DYRK30.52222838
111TSSK60.51886065
112MAP3K10.51878747
113CAMK2B0.50497578
114MAP2K40.48801724
115MAPK100.48749470
116CHUK0.48403973
117NEK10.48331793
118SRPK10.47929085
119RIPK10.47853079
120MAP2K20.47777207
121CSNK1E0.47526138
122CAMKK10.47256881
123CHEK20.47077819
124ATM0.46585916
125BCKDK0.46470689
126MAPK140.46061160
127TNK20.45966599
128MKNK10.45515104
129MAP3K110.45462134
130AKT20.41583982
131CDK90.41441278
132TBK10.39897356
133RPS6KA40.39689529
134PRKCG0.39449492
135BCR0.38485474
136CDK40.38302890
137ERN10.38182278
138CDK140.37212507
139STK380.36587744
140RPS6KA10.34911525
141RPS6KA30.34629912
142DYRK1B0.34533226
143PRKCH0.33907296
144PRKD20.33595351

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030401.97334301
2mRNA surveillance pathway_Homo sapiens_hsa030151.92303315
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90422594
4Fructose and mannose metabolism_Homo sapiens_hsa000511.79613610
5Nicotine addiction_Homo sapiens_hsa050331.67882497
6DNA replication_Homo sapiens_hsa030301.66389181
7Basal cell carcinoma_Homo sapiens_hsa052171.62298620
8Insulin signaling pathway_Homo sapiens_hsa049101.60972874
9Long-term potentiation_Homo sapiens_hsa047201.60806730
10Mismatch repair_Homo sapiens_hsa034301.60102697
11Acute myeloid leukemia_Homo sapiens_hsa052211.57507117
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55741221
13Hedgehog signaling pathway_Homo sapiens_hsa043401.54305732
14Non-homologous end-joining_Homo sapiens_hsa034501.51024006
15Sulfur relay system_Homo sapiens_hsa041221.48941567
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45275063
17Colorectal cancer_Homo sapiens_hsa052101.43471755
18Base excision repair_Homo sapiens_hsa034101.42272443
19Circadian entrainment_Homo sapiens_hsa047131.40761194
20mTOR signaling pathway_Homo sapiens_hsa041501.36478404
21Notch signaling pathway_Homo sapiens_hsa043301.36042208
22Glutamatergic synapse_Homo sapiens_hsa047241.33017126
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32234414
24RNA transport_Homo sapiens_hsa030131.31989802
25ErbB signaling pathway_Homo sapiens_hsa040121.31583017
26Glioma_Homo sapiens_hsa052141.31512504
27Synaptic vesicle cycle_Homo sapiens_hsa047211.31182652
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.29780700
29Amphetamine addiction_Homo sapiens_hsa050311.29559728
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28719219
31Dopaminergic synapse_Homo sapiens_hsa047281.27672580
32AMPK signaling pathway_Homo sapiens_hsa041521.26830952
33Non-small cell lung cancer_Homo sapiens_hsa052231.26645024
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.25858344
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25124512
36Oocyte meiosis_Homo sapiens_hsa041141.24424998
37T cell receptor signaling pathway_Homo sapiens_hsa046601.22293268
38Axon guidance_Homo sapiens_hsa043601.19275499
39Dilated cardiomyopathy_Homo sapiens_hsa054141.18923138
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17672527
41Cell cycle_Homo sapiens_hsa041101.16403362
42Wnt signaling pathway_Homo sapiens_hsa043101.16286110
43Olfactory transduction_Homo sapiens_hsa047401.15536424
44Gastric acid secretion_Homo sapiens_hsa049711.14888560
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14512486
46Biosynthesis of amino acids_Homo sapiens_hsa012301.13985679
47Chronic myeloid leukemia_Homo sapiens_hsa052201.12609593
48Morphine addiction_Homo sapiens_hsa050321.11730357
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11393932
50Cardiac muscle contraction_Homo sapiens_hsa042601.11086634
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10613928
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10522147
53Pentose phosphate pathway_Homo sapiens_hsa000301.10329694
54Hippo signaling pathway_Homo sapiens_hsa043901.07935070
55VEGF signaling pathway_Homo sapiens_hsa043701.06696958
56MicroRNAs in cancer_Homo sapiens_hsa052061.06521185
57Oxytocin signaling pathway_Homo sapiens_hsa049211.06088264
58Cocaine addiction_Homo sapiens_hsa050301.04819787
59Endometrial cancer_Homo sapiens_hsa052131.03692583
60Lysine degradation_Homo sapiens_hsa003101.01685568
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01417285
62Cholinergic synapse_Homo sapiens_hsa047251.01390881
63Type II diabetes mellitus_Homo sapiens_hsa049301.00526964
64HTLV-I infection_Homo sapiens_hsa051660.99797830
65Shigellosis_Homo sapiens_hsa051310.99722225
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99145520
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98873873
68GABAergic synapse_Homo sapiens_hsa047270.98474384
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97708899
70Hepatitis B_Homo sapiens_hsa051610.97184754
71Insulin secretion_Homo sapiens_hsa049110.95750623
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94747628
73Alcoholism_Homo sapiens_hsa050340.94255328
74Melanogenesis_Homo sapiens_hsa049160.94219317
75Prolactin signaling pathway_Homo sapiens_hsa049170.94044037
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92102429
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92038987
78Other glycan degradation_Homo sapiens_hsa005110.91790483
79MAPK signaling pathway_Homo sapiens_hsa040100.91511711
80Gap junction_Homo sapiens_hsa045400.90693141
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90662136
82Dorso-ventral axis formation_Homo sapiens_hsa043200.90005741
83Estrogen signaling pathway_Homo sapiens_hsa049150.87684025
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86247445
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86029926
86Circadian rhythm_Homo sapiens_hsa047100.85827542
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.85461300
88Renal cell carcinoma_Homo sapiens_hsa052110.83869283
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83851588
90Choline metabolism in cancer_Homo sapiens_hsa052310.83788380
91GnRH signaling pathway_Homo sapiens_hsa049120.83763270
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82834908
93B cell receptor signaling pathway_Homo sapiens_hsa046620.80727182
94Herpes simplex infection_Homo sapiens_hsa051680.80185250
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79687055
96Glucagon signaling pathway_Homo sapiens_hsa049220.79180463
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78789104
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77032183
99Long-term depression_Homo sapiens_hsa047300.76840732
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76212587
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75699465
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75252003
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.75237083
104RNA degradation_Homo sapiens_hsa030180.74901804
105Apoptosis_Homo sapiens_hsa042100.73469987
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.72443990
107Osteoclast differentiation_Homo sapiens_hsa043800.71604660
108Salivary secretion_Homo sapiens_hsa049700.70614296
109Pancreatic cancer_Homo sapiens_hsa052120.69927689
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69866811
111TNF signaling pathway_Homo sapiens_hsa046680.68894041
112Calcium signaling pathway_Homo sapiens_hsa040200.68850141
113Primary immunodeficiency_Homo sapiens_hsa053400.68175419
114Proteoglycans in cancer_Homo sapiens_hsa052050.68145909
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67630827
116Bladder cancer_Homo sapiens_hsa052190.67427547
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66955539
118Carbon metabolism_Homo sapiens_hsa012000.66674602
119Salmonella infection_Homo sapiens_hsa051320.66201054
120Regulation of autophagy_Homo sapiens_hsa041400.66149574
121cAMP signaling pathway_Homo sapiens_hsa040240.65804974
122Epstein-Barr virus infection_Homo sapiens_hsa051690.65656955
123Insulin resistance_Homo sapiens_hsa049310.65012043
124Inositol phosphate metabolism_Homo sapiens_hsa005620.64736612
125Viral carcinogenesis_Homo sapiens_hsa052030.64214810
126Rap1 signaling pathway_Homo sapiens_hsa040150.63684224
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62226512
128HIF-1 signaling pathway_Homo sapiens_hsa040660.59975987
129Renin secretion_Homo sapiens_hsa049240.59948465
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59926120
131Pathways in cancer_Homo sapiens_hsa052000.59396677
132Nucleotide excision repair_Homo sapiens_hsa034200.58808967
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57695730
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57384227
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57214248
136RNA polymerase_Homo sapiens_hsa030200.56546932
137Pyrimidine metabolism_Homo sapiens_hsa002400.55503464
138FoxO signaling pathway_Homo sapiens_hsa040680.51309705
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50577844
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49751260

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