ATXN7L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.58694328
2locomotory exploration behavior (GO:0035641)6.09025160
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78706217
4layer formation in cerebral cortex (GO:0021819)5.49922619
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24230628
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.04137031
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03614225
8glutamate secretion (GO:0014047)4.88449165
9regulation of synaptic vesicle exocytosis (GO:2000300)4.51227115
10synaptic vesicle exocytosis (GO:0016079)4.50968937
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45837410
12negative regulation of erythrocyte differentiation (GO:0045647)4.42772720
13vocalization behavior (GO:0071625)4.39219270
14sodium ion export (GO:0071436)4.30773970
15exploration behavior (GO:0035640)4.29880702
16regulation of glutamate receptor signaling pathway (GO:1900449)4.28184846
17dendritic spine morphogenesis (GO:0060997)4.26956422
18proline transport (GO:0015824)4.08061010
19regulation of neuronal synaptic plasticity (GO:0048168)4.05486358
20regulation of synapse structural plasticity (GO:0051823)4.03635540
21neurotransmitter secretion (GO:0007269)3.95784980
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93662318
23activation of protein kinase A activity (GO:0034199)3.91447281
24neuromuscular process controlling balance (GO:0050885)3.90678520
25regulation of synaptic vesicle transport (GO:1902803)3.85800132
26regulation of ARF protein signal transduction (GO:0032012)3.82535874
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.80853407
28G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.77906479
29protein localization to synapse (GO:0035418)3.62479424
30cell migration in hindbrain (GO:0021535)3.58503749
31cellular potassium ion homeostasis (GO:0030007)3.57787254
32positive regulation of synapse maturation (GO:0090129)3.56270885
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.44251388
34regulation of dendritic spine morphogenesis (GO:0061001)3.43529796
35regulation of ARF GTPase activity (GO:0032312)3.38695774
36establishment of nucleus localization (GO:0040023)3.31764497
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.30652863
38pre-miRNA processing (GO:0031054)3.29646561
39regulation of early endosome to late endosome transport (GO:2000641)3.28859387
40gamma-aminobutyric acid transport (GO:0015812)3.27163188
41regulation of clathrin-mediated endocytosis (GO:2000369)3.26650593
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26207660
43dendrite morphogenesis (GO:0048813)3.25516769
44cell communication by electrical coupling (GO:0010644)3.25045850
45long-term memory (GO:0007616)3.18173584
46adherens junction assembly (GO:0034333)3.16706653
47prepulse inhibition (GO:0060134)3.16327113
48mannose metabolic process (GO:0006013)3.13432578
49neuronal action potential propagation (GO:0019227)3.13111081
50positive regulation of fibroblast migration (GO:0010763)3.09226158
51vesicle transport along microtubule (GO:0047496)3.09205897
52regulation of synaptic plasticity (GO:0048167)3.07566958
53glycine transport (GO:0015816)3.07484615
54focal adhesion assembly (GO:0048041)3.06593277
55cell-substrate adherens junction assembly (GO:0007045)3.06593277
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.06403969
57clathrin coat assembly (GO:0048268)3.06234217
58neurotransmitter-gated ion channel clustering (GO:0072578)3.05045722
59positive regulation of membrane potential (GO:0045838)3.01578986
60synaptic vesicle endocytosis (GO:0048488)2.99298325
61activation of Rac GTPase activity (GO:0032863)2.96868791
62cerebellar Purkinje cell layer development (GO:0021680)2.95793426
63dendritic spine organization (GO:0097061)2.95441521
64cerebellar Purkinje cell differentiation (GO:0021702)2.95356183
65synaptic transmission, glutamatergic (GO:0035249)2.94256992
66regulation of excitatory postsynaptic membrane potential (GO:0060079)2.92234564
67response to laminar fluid shear stress (GO:0034616)2.92120123
68signal complex assembly (GO:0007172)2.91449823
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90073946
70positive regulation of dendritic spine morphogenesis (GO:0061003)2.87306728
71nerve growth factor signaling pathway (GO:0038180)2.86222759
72alanine transport (GO:0032328)2.84411924
73neurotransmitter transport (GO:0006836)2.84101271
74embryonic process involved in female pregnancy (GO:0060136)2.82444706
75neuromuscular process controlling posture (GO:0050884)2.79891384
76auditory behavior (GO:0031223)2.78754215
77organelle transport along microtubule (GO:0072384)2.78321056
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77240905
79neuromuscular process (GO:0050905)2.76580213
80positive regulation by symbiont of host defense response (GO:0052509)2.76396082
81modulation by symbiont of host defense response (GO:0052031)2.76396082
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76396082
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76396082
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.76396082
85modulation by symbiont of host immune response (GO:0052553)2.76396082
86modulation by symbiont of host cellular process (GO:0044068)2.76350942
87regulation of translational termination (GO:0006449)2.75146628
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74501499
89response to muramyl dipeptide (GO:0032495)2.74093986
90negative regulation of microtubule polymerization (GO:0031115)2.73648168
91regulation of T-helper 2 cell differentiation (GO:0045628)2.73260300
92regulation of postsynaptic membrane potential (GO:0060078)2.72881744
93regulation of NFAT protein import into nucleus (GO:0051532)2.72628305
94stress fiber assembly (GO:0043149)2.69663502
95regulation of dendritic spine development (GO:0060998)2.68748481
96regulation of neurotransmitter levels (GO:0001505)2.68262758
973-UTR-mediated mRNA stabilization (GO:0070935)2.68107712
98dopamine receptor signaling pathway (GO:0007212)2.67247592
99glutamate receptor signaling pathway (GO:0007215)2.66017229
100modulation by virus of host process (GO:0019054)2.65319797
101peptidyl-lysine dimethylation (GO:0018027)2.65156992
102neuronal ion channel clustering (GO:0045161)2.65096029
103axonal fasciculation (GO:0007413)2.64960875
104positive regulation of synaptic transmission, GABAergic (GO:0032230)2.64648365
105glial cell proliferation (GO:0014009)2.63818288
106positive regulation of dendritic spine development (GO:0060999)2.63190446
107cellular sodium ion homeostasis (GO:0006883)2.62880013
108neuron-neuron synaptic transmission (GO:0007270)2.62287738
109regulation of neurotransmitter secretion (GO:0046928)2.61979275
110cortical actin cytoskeleton organization (GO:0030866)2.61411799
111regulation of Rap GTPase activity (GO:0032317)2.61265224
112cerebellar granule cell differentiation (GO:0021707)2.59950089
113positive regulation of gamma-delta T cell activation (GO:0046645)2.59481307
114positive regulation of Rap GTPase activity (GO:0032854)2.59411523
115potassium ion import (GO:0010107)2.58804535
116positive regulation of protein dephosphorylation (GO:0035307)2.58628825
117amino acid import (GO:0043090)2.58078595
118antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57806866
119neuron recognition (GO:0008038)2.57689946
120neuron cell-cell adhesion (GO:0007158)2.57375338
121regulation of leukocyte degranulation (GO:0043300)2.57156005
122response to auditory stimulus (GO:0010996)2.56244307
123protein localization to endosome (GO:0036010)2.56146396
124L-amino acid import (GO:0043092)2.55982904
125positive regulation of Cdc42 GTPase activity (GO:0043089)2.55876392
126axon cargo transport (GO:0008088)2.54588470
127negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54538895
128negative regulation of cell killing (GO:0031342)2.54538895
129negative regulation of toll-like receptor signaling pathway (GO:0034122)2.54144067
130regulation of regulated secretory pathway (GO:1903305)2.50504470
131intraspecies interaction between organisms (GO:0051703)2.50409421
132barbed-end actin filament capping (GO:0051016)2.50193938
133positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.48912236
134cell-substrate junction assembly (GO:0007044)2.48225017
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.47714890
136apoptotic process involved in morphogenesis (GO:0060561)2.45396146
137response to peptidoglycan (GO:0032494)2.44112809
138peptidyl-tyrosine autophosphorylation (GO:0038083)2.43360632
139semaphorin-plexin signaling pathway (GO:0071526)2.43315585
140protein targeting to plasma membrane (GO:0072661)2.42878307
141cell-cell junction maintenance (GO:0045217)2.42775744
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41419514
143activation of MAPKKK activity (GO:0000185)2.40885158
144maternal placenta development (GO:0001893)2.39689788
145planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39233626
146protein retention in ER lumen (GO:0006621)2.39151053
147regulation of extracellular matrix disassembly (GO:0010715)2.38786994
148positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.38464544
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37211074
150positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.36206536
151thymic T cell selection (GO:0045061)2.35981799
152antigen processing and presentation of endogenous antigen (GO:0019883)2.35871072
153activation of JUN kinase activity (GO:0007257)2.34676270
154positive thymic T cell selection (GO:0045059)2.34399178
155macrophage activation involved in immune response (GO:0002281)2.34374324
156regulation of myeloid leukocyte mediated immunity (GO:0002886)2.33618667
157histone H3-K36 demethylation (GO:0070544)2.32071708
158epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29602287
159detection of other organism (GO:0098543)2.29548579
160regulation of defense response to virus by virus (GO:0050690)2.29538589
161regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.29369740
162positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.29369740
163regulation of histone H3-K27 methylation (GO:0061085)2.28765463
164positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.28700909
165negative regulation of cell size (GO:0045792)2.28022574
166maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25010396
167negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.24611396
168retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.24562401
169intracellular estrogen receptor signaling pathway (GO:0030520)2.24016481
170positive regulation of receptor recycling (GO:0001921)2.22882159
171germinal center formation (GO:0002467)2.22686880
172pinocytosis (GO:0006907)2.22550561
173cortical cytoskeleton organization (GO:0030865)2.22465958
174detection of bacterium (GO:0016045)2.20480325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.60204537
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.58040196
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.12550112
4ZFP281_18757296_ChIP-ChIP_E14_Mouse2.81113855
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.58681848
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55093635
7KDM2B_26808549_Chip-Seq_K562_Human2.48883007
8DROSHA_22980978_ChIP-Seq_HELA_Human2.48817773
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45150312
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.44596385
11* KDM2B_26808549_Chip-Seq_DND41_Human2.39863427
12* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.38917795
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23082640
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.17723168
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13680391
16REST_21632747_ChIP-Seq_MESCs_Mouse2.13393205
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11957567
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11408553
19MYC_22102868_ChIP-Seq_BL_Human2.09960633
20EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.09540245
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.03450947
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.01273351
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.00893417
24LXR_22292898_ChIP-Seq_THP-1_Human1.97357637
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97143314
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96938149
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96938149
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.95741329
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.93121240
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89307128
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88509253
32* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87964201
33* KDM2B_26808549_Chip-Seq_JURKAT_Human1.87678009
34* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85986738
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84169570
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83591729
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83469255
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81838143
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77896324
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.76397490
41VDR_24763502_ChIP-Seq_THP-1_Human1.76241155
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76206849
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75329297
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73872871
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73853079
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.66040583
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65955339
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65595113
49ZNF263_19887448_ChIP-Seq_K562_Human1.62280340
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60386866
51* MAF_26560356_Chip-Seq_TH1_Human1.60122417
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.58269761
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56566041
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54362619
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.53653691
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47159037
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46751872
58* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46227026
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44832022
60* CREB1_26743006_Chip-Seq_LNCaP_Human1.43650018
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43325371
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42417035
63CLOCK_20551151_ChIP-Seq_293T_Human1.42389938
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.40474375
65* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39642483
66* UTX_26944678_Chip-Seq_JUKART_Human1.38307775
67* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33701706
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33531083
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33374351
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31895984
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.31705252
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.31574697
73* MAF_26560356_Chip-Seq_TH2_Human1.31002080
74* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.30736115
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29803240
76* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28551390
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.28396632
78RACK7_27058665_Chip-Seq_MCF-7_Human1.27965625
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27494342
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.26912473
81* TET1_21451524_ChIP-Seq_MESCs_Mouse1.26393050
82SMC4_20622854_ChIP-Seq_HELA_Human1.25697129
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23513204
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20148996
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19522878
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19005783
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18668472
88CTCF_27219007_Chip-Seq_Bcells_Human1.17738675
89* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16201930
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13547857
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13192071
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.12785190
93* NCOR1_26117541_ChIP-Seq_K562_Human1.12702041
94TET1_21490601_ChIP-Seq_MESCs_Mouse1.12560656
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12166323
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11406854
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10744007
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10375967
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08049226
100P68_20966046_ChIP-Seq_HELA_Human1.07310181
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06944192
102* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06696896
103AR_19668381_ChIP-Seq_PC3_Human1.06475326
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06133947
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06104504
106GATA1_19941826_ChIP-Seq_K562_Human1.04850752
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03882571
108VDR_21846776_ChIP-Seq_THP-1_Human1.03858651
109OCT4_19829295_ChIP-Seq_ESCs_Human1.03705719
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03275800
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02767951
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00507030
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98008390
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97742654
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97433588
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96565286
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96280855
118* ATF3_27146783_Chip-Seq_COLON_Human0.96099691
119SCL_19346495_ChIP-Seq_HPC-7_Human0.95764767
120* KLF4_19829295_ChIP-Seq_ESCs_Human0.95300638
121* TP53_22127205_ChIP-Seq_IMR90_Human0.95194604
122FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94820088
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.93790168
124BCOR_27268052_Chip-Seq_Bcells_Human0.93230601
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93179518
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92578217
127* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92431560
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91887215
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91571453
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.91166884
131STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90572789
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90078451
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.89674851
134* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89355186
135AR_21572438_ChIP-Seq_LNCaP_Human0.89209222
136OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88085549
137* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87466828
138NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87106847
139DPY_21335234_ChIP-Seq_ESCs_Mouse0.86928648
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86840307
141SPI1_23127762_ChIP-Seq_K562_Human0.83830049
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.83769123
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83694521
144SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83094593
145* SMAD4_21741376_ChIP-Seq_ESCs_Human0.82923348
146* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82714983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.60332196
2MP0003635_abnormal_synaptic_transmissio3.98555551
3MP0004270_analgesia3.66708506
4MP0002063_abnormal_learning/memory/cond3.15790244
5MP0004858_abnormal_nervous_system2.92795554
6MP0003880_abnormal_central_pattern2.87769006
7MP0002822_catalepsy2.77289677
8MP0009745_abnormal_behavioral_response2.73068765
9MP0003436_decreased_susceptibility_to2.62461334
10MP0002064_seizures2.60605548
11MP0008260_abnormal_autophagy2.42190303
12MP0010234_abnormal_vibrissa_follicle2.37157378
13MP0003705_abnormal_hypodermis_morpholog2.35450779
14MP0005451_abnormal_body_composition2.34051013
15MP0009780_abnormal_chondrocyte_physiolo2.33993979
16MP0005423_abnormal_somatic_nervous2.33323759
17MP0005058_abnormal_lysosome_morphology2.30873644
18MP0003566_abnormal_cell_adhesion2.29875307
19MP0009046_muscle_twitch2.25258409
20MP0005409_darkened_coat_color2.22454085
21MP0008961_abnormal_basal_metabolism2.17116768
22MP0002572_abnormal_emotion/affect_behav2.16490280
23MP0001968_abnormal_touch/_nociception2.15394024
24MP0004811_abnormal_neuron_physiology2.14180222
25MP0003329_amyloid_beta_deposits2.12850481
26MP0002909_abnormal_adrenal_gland2.08023535
27MP0002734_abnormal_mechanical_nocicepti2.04591669
28MP0003283_abnormal_digestive_organ2.02752635
29MP0003191_abnormal_cellular_cholesterol1.97865257
30MP0001486_abnormal_startle_reflex1.91481944
31MP0003303_peritoneal_inflammation1.84626598
32MP0002733_abnormal_thermal_nociception1.81640559
33MP0008569_lethality_at_weaning1.80363040
34MP0004947_skin_inflammation1.79232382
35MP0000955_abnormal_spinal_cord1.71551873
36MP0004885_abnormal_endolymph1.70195301
37MP0002272_abnormal_nervous_system1.66717370
38MP0003453_abnormal_keratinocyte_physiol1.65636854
39MP0005623_abnormal_meninges_morphology1.63412858
40MP0003787_abnormal_imprinting1.61752513
41MP0000569_abnormal_digit_pigmentation1.60814770
42MP0005076_abnormal_cell_differentiation1.60640670
43MP0002877_abnormal_melanocyte_morpholog1.59941905
44MP0001970_abnormal_pain_threshold1.55238574
45MP0000778_abnormal_nervous_system1.54871589
46MP0001501_abnormal_sleep_pattern1.50536787
47MP0001440_abnormal_grooming_behavior1.50299027
48MP0002184_abnormal_innervation1.47513493
49MP0000858_altered_metastatic_potential1.46770088
50MP0003123_paternal_imprinting1.43722226
51MP0003075_altered_response_to1.42365203
52MP0003763_abnormal_thymus_physiology1.39401329
53MP0005167_abnormal_blood-brain_barrier1.35514990
54MP0009840_abnormal_foam_cell1.35359110
55MP0002735_abnormal_chemical_nociception1.34842715
56MP0003633_abnormal_nervous_system1.34412395
57MP0002419_abnormal_innate_immunity1.31351136
58MP0002396_abnormal_hematopoietic_system1.30447562
59MP0002998_abnormal_bone_remodeling1.30028763
60MP0002796_impaired_skin_barrier1.27528196
61MP0002736_abnormal_nociception_after1.26942742
62MP0003122_maternal_imprinting1.26853058
63MP0002557_abnormal_social/conspecific_i1.25845879
64MP0005386_behavior/neurological_phenoty1.24293073
65MP0004924_abnormal_behavior1.24293073
66MP0001348_abnormal_lacrimal_gland1.23077475
67MP0008438_abnormal_cutaneous_collagen1.22914029
68MP0002152_abnormal_brain_morphology1.22673414
69MP0004510_myositis1.22161042
70MP0002882_abnormal_neuron_morphology1.21306931
71MP0003879_abnormal_hair_cell1.21050497
72MP0002066_abnormal_motor_capabilities/c1.20537180
73MP0010352_gastrointestinal_tract_polyps1.20090520
74MP0001849_ear_inflammation1.19633629
75MP0001533_abnormal_skeleton_physiology1.19077831
76MP0005000_abnormal_immune_tolerance1.18912606
77MP0005464_abnormal_platelet_physiology1.17706551
78MP0002067_abnormal_sensory_capabilities1.16917307
79MP0005025_abnormal_response_to1.16533230
80MP0003172_abnormal_lysosome_physiology1.14070265
81MP0004264_abnormal_extraembryonic_tissu1.13483956
82MP0000685_abnormal_immune_system1.13147824
83MP0003183_abnormal_peptide_metabolism1.12766587
84MP0004233_abnormal_muscle_weight1.12567387
85MP0001958_emphysema1.11785866
86MP0000920_abnormal_myelination1.10611792
87MP0002653_abnormal_ependyma_morphology1.10530226
88MP0003828_pulmonary_edema1.10464063
89MP0000604_amyloidosis1.09248592
90MP0009672_abnormal_birth_weight1.08454896
91MP0003119_abnormal_digestive_system1.07469319
92MP0003631_nervous_system_phenotype1.06941664
93MP0003724_increased_susceptibility_to1.01343096
94MP0001915_intracranial_hemorrhage1.00791187
95MP0008874_decreased_physiological_sensi1.00560460
96MP0005621_abnormal_cell_physiology1.00478273
97MP0005666_abnormal_adipose_tissue0.99642159
98MP0002089_abnormal_postnatal_growth/wei0.97404959
99MP0003279_aneurysm0.97387768
100MP0003861_abnormal_nervous_system0.96802976
101MP0009333_abnormal_splenocyte_physiolog0.96210875
102MP0002420_abnormal_adaptive_immunity0.96177436
103MP0002398_abnormal_bone_marrow0.95980119
104MP0001819_abnormal_immune_cell0.95925946
105MP0008770_decreased_survivor_rate0.95324358
106MP0004808_abnormal_hematopoietic_stem0.94714585
107MP0001835_abnormal_antigen_presentation0.94386540
108MP0000537_abnormal_urethra_morphology0.93934492
109MP0003300_gastrointestinal_ulcer0.93353311
110MP0001851_eye_inflammation0.93182873
111MP0000678_abnormal_parathyroid_gland0.92784953
112MP0005187_abnormal_penis_morphology0.89996283
113MP0000767_abnormal_smooth_muscle0.89522826
114MP0000703_abnormal_thymus_morphology0.88678270
115MP0005257_abnormal_intraocular_pressure0.88025222
116MP0000751_myopathy0.87732779
117MP0002723_abnormal_immune_serum0.85878839
118MP0005387_immune_system_phenotype0.85255035
119MP0001790_abnormal_immune_system0.85255035
120MP0005023_abnormal_wound_healing0.85140581
121MP0003448_altered_tumor_morphology0.84808303
122MP0005375_adipose_tissue_phenotype0.83869897
123MP0002452_abnormal_antigen_presenting0.83616307
124MP0000733_abnormal_muscle_development0.83429017
125MP0004130_abnormal_muscle_cell0.82885971
126MP0001800_abnormal_humoral_immune0.82039757
127MP0005501_abnormal_skin_physiology0.80294952
128MP0010155_abnormal_intestine_physiology0.79898039
129MP0005499_abnormal_olfactory_system0.79077572
130MP0005394_taste/olfaction_phenotype0.79077572
131MP0000716_abnormal_immune_system0.78738470
132MP0003632_abnormal_nervous_system0.78672301
133MP0000534_abnormal_ureter_morphology0.77670036
134MP0002069_abnormal_eating/drinking_beha0.76094972
135MP0008872_abnormal_physiological_respon0.75282791
136MP0003045_fibrosis0.75158305
137MP0006082_CNS_inflammation0.74705604
138MP0003634_abnormal_glial_cell0.74253370
139MP0004185_abnormal_adipocyte_glucose0.72485876
140MP0010630_abnormal_cardiac_muscle0.72004631
141MP0003690_abnormal_glial_cell0.71866437
142MP0001730_embryonic_growth_arrest0.71052228
143MP0003121_genomic_imprinting0.70953656
144MP0002060_abnormal_skin_morphology0.70217396
145MP0002429_abnormal_blood_cell0.70068700
146MP0000490_abnormal_crypts_of0.69678523
147MP0001177_atelectasis0.68392945
148MP0000003_abnormal_adipose_tissue0.68100991
149MP0000013_abnormal_adipose_tissue0.67861823
150MP0002249_abnormal_larynx_morphology0.67457526
151MP0003091_abnormal_cell_migration0.66679987
152MP0009278_abnormal_bone_marrow0.66583922
153MP0002234_abnormal_pharynx_morphology0.66252856
154MP0002084_abnormal_developmental_patter0.66210382
155MP0010769_abnormal_survival0.65254137
156MP0005166_decreased_susceptibility_to0.63601558
157MP0000747_muscle_weakness0.61502822
158MP0002081_perinatal_lethality0.60558644
159MP0010768_mortality/aging0.60368949
160MP0001943_abnormal_respiration0.57952951
161MP0001299_abnormal_eye_distance/0.56554735
162MP0002082_postnatal_lethality0.55969082
163MP0010770_preweaning_lethality0.55969082
164MP0003115_abnormal_respiratory_system0.55450860

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.18220290
2Abnormality of the lower motor neuron (HP:0002366)4.01337484
3Visual hallucinations (HP:0002367)3.86470881
4Focal seizures (HP:0007359)3.75494664
5Focal motor seizures (HP:0011153)3.72394575
6Hyperacusis (HP:0010780)3.46710352
7Insomnia (HP:0100785)3.27401215
8Papilledema (HP:0001085)3.26654991
9Supranuclear gaze palsy (HP:0000605)3.19900929
10Annular pancreas (HP:0001734)3.15829389
11Action tremor (HP:0002345)3.06476117
12Pointed chin (HP:0000307)3.06384269
13Ankle clonus (HP:0011448)3.01036193
14Impaired vibration sensation in the lower limbs (HP:0002166)2.83763172
15Urinary urgency (HP:0000012)2.75741383
16Eczematoid dermatitis (HP:0000976)2.72664958
17Urinary bladder sphincter dysfunction (HP:0002839)2.72297688
18Neurofibrillary tangles (HP:0002185)2.66945294
19Depression (HP:0000716)2.64158231
20Protrusio acetabuli (HP:0003179)2.62034956
21Ankyloglossia (HP:0010296)2.60851033
22Elfin facies (HP:0004428)2.60668664
23Termporal pattern (HP:0011008)2.58119957
24Insidious onset (HP:0003587)2.58119957
25Impaired social interactions (HP:0000735)2.54915779
26Abnormal social behavior (HP:0012433)2.54915779
27Macroorchidism (HP:0000053)2.51618515
28Poor eye contact (HP:0000817)2.50772073
29Renal duplication (HP:0000075)2.49716530
30Amyotrophic lateral sclerosis (HP:0007354)2.48822067
31Hemiplegia (HP:0002301)2.48514656
32Overriding aorta (HP:0002623)2.44043278
33Dysmetric saccades (HP:0000641)2.43859233
34Postural instability (HP:0002172)2.42335124
35Resting tremor (HP:0002322)2.38572726
36Renovascular hypertension (HP:0100817)2.35948658
37Mutism (HP:0002300)2.35886042
38Atonic seizures (HP:0010819)2.35842745
39Achilles tendon contracture (HP:0001771)2.34658219
40Epileptic encephalopathy (HP:0200134)2.33856656
41Upper limb amyotrophy (HP:0009129)2.33478359
42Distal upper limb amyotrophy (HP:0007149)2.33478359
43Apathy (HP:0000741)2.33367030
44Cellulitis (HP:0100658)2.28658277
45Abnormality of the astrocytes (HP:0100707)2.28358232
46Astrocytoma (HP:0009592)2.28358232
47Broad face (HP:0000283)2.27813058
48Impaired smooth pursuit (HP:0007772)2.26446793
49Bundle branch block (HP:0011710)2.25782970
50Genetic anticipation (HP:0003743)2.25696257
51Cerebral inclusion bodies (HP:0100314)2.25030384
52Absence seizures (HP:0002121)2.24125219
53Generalized tonic-clonic seizures (HP:0002069)2.21959539
54Asymmetry of the thorax (HP:0001555)2.19767104
55Cerebral aneurysm (HP:0004944)2.18193825
56Progressive cerebellar ataxia (HP:0002073)2.18053255
57Ventricular fibrillation (HP:0001663)2.17287301
58Dysdiadochokinesis (HP:0002075)2.16934630
59Lower limb amyotrophy (HP:0007210)2.14844134
60Abnormality of oral frenula (HP:0000190)2.14189374
61Slow saccadic eye movements (HP:0000514)2.13120806
62Neoplasm of the heart (HP:0100544)2.12543312
63Distal lower limb amyotrophy (HP:0008944)2.11520086
64Abnormality of the Achilles tendon (HP:0005109)2.11404145
65Spastic gait (HP:0002064)2.10231879
66Thin bony cortex (HP:0002753)2.09320608
67Disproportionate tall stature (HP:0001519)2.08281987
68Diminished motivation (HP:0000745)2.08204819
69Premature rupture of membranes (HP:0001788)2.07616165
70Febrile seizures (HP:0002373)2.07580858
71Torticollis (HP:0000473)2.07015158
72Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06689690
73Flat acetabular roof (HP:0003180)2.05842148
74Long palpebral fissure (HP:0000637)2.05027772
75Megalencephaly (HP:0001355)2.03733766
76Intention tremor (HP:0002080)2.03644554
77Amblyopia (HP:0000646)2.02493112
78Bowel diverticulosis (HP:0005222)2.02046756
79Hand muscle atrophy (HP:0009130)2.01206360
80Abnormality of ocular smooth pursuit (HP:0000617)2.00856635
81Dysmetria (HP:0001310)2.00643755
82Segmental peripheral demyelination/remyelination (HP:0003481)2.00565526
83Stereotypic behavior (HP:0000733)1.99826692
84Ulnar bowing (HP:0003031)1.99110236
85Truncal ataxia (HP:0002078)1.97838319
86Polygenic inheritance (HP:0010982)1.96574487
87Dialeptic seizures (HP:0011146)1.95024460
88Shallow orbits (HP:0000586)1.94785280
89Ependymoma (HP:0002888)1.94669418
90Obstructive sleep apnea (HP:0002870)1.94134135
91Abnormality of the fingertips (HP:0001211)1.92798447
92Intellectual disability, profound (HP:0002187)1.91591607
93Heterotopia (HP:0002282)1.89268115
94Rapidly progressive (HP:0003678)1.88964941
95Arterial tortuosity (HP:0005116)1.88119273
96Abnormality of macrophages (HP:0004311)1.87460349
97Sacral dimple (HP:0000960)1.84819134
98Dilatation of the ascending aorta (HP:0005111)1.84474171
99Lower limb asymmetry (HP:0100559)1.84080597
100Vertebral compression fractures (HP:0002953)1.83760145
101Diplopia (HP:0000651)1.83462895
102Abnormality of binocular vision (HP:0011514)1.83462895
103Centrally nucleated skeletal muscle fibers (HP:0003687)1.82801661
104Hemiparesis (HP:0001269)1.82516884
105Bradykinesia (HP:0002067)1.82321772
106Flat cornea (HP:0007720)1.82073198
107Hypercortisolism (HP:0001578)1.81028452
108Peripheral hypomyelination (HP:0007182)1.81010905
109Gingivitis (HP:0000230)1.80948530
110Abnormality of the corticospinal tract (HP:0002492)1.80489330
111Mitral regurgitation (HP:0001653)1.80413746
112Enlarged penis (HP:0000040)1.79837534
113Increased IgE level (HP:0003212)1.79539266
114Syringomyelia (HP:0003396)1.79518221
115Spinal cord lesions (HP:0100561)1.79518221
116Genu recurvatum (HP:0002816)1.79238141
117Inappropriate behavior (HP:0000719)1.79135323
118Abnormal eating behavior (HP:0100738)1.78988035
119Hemorrhage of the eye (HP:0011885)1.78679102
120Clonus (HP:0002169)1.77380350
121Focal dystonia (HP:0004373)1.77233149
122Lower limb muscle weakness (HP:0007340)1.76346593
123Generalized hypotonia (HP:0001290)1.76272575
124Dysostosis multiplex (HP:0000943)1.75596930
125Onion bulb formation (HP:0003383)1.75373814
126Fragile skin (HP:0001030)1.73020598
127Recurrent abscess formation (HP:0002722)1.72990860
128Impaired vibratory sensation (HP:0002495)1.72930809
129Turricephaly (HP:0000262)1.72598963
130Neuronal loss in central nervous system (HP:0002529)1.72286044
131Fibroma (HP:0010614)1.72277726
132Metaphyseal cupping (HP:0003021)1.71910347
133Broad-based gait (HP:0002136)1.71787512
134Deep venous thrombosis (HP:0002625)1.71495222
135Vascular tortuosity (HP:0004948)1.71151465
136Arnold-Chiari malformation (HP:0002308)1.70907164
137Decreased motor nerve conduction velocity (HP:0003431)1.70234751
138Aneurysm (HP:0002617)1.69972442
139Increased connective tissue (HP:0009025)1.69543955
140Recurrent bacterial skin infections (HP:0005406)1.69033907
141Increased variability in muscle fiber diameter (HP:0003557)1.68776783
142Abnormality of the thoracic spine (HP:0100711)1.68090199
143Subacute progressive viral hepatitis (HP:0006572)1.67802385
144Status epilepticus (HP:0002133)1.67638554
145Gastrointestinal infarctions (HP:0005244)1.66995146
146Supernumerary nipples (HP:0002558)1.64363928
147Mitral valve prolapse (HP:0001634)1.60373768
148Blue sclerae (HP:0000592)1.58677019
149Increased cerebral lipofuscin (HP:0011813)1.58100641
150Bronchomalacia (HP:0002780)1.57136356
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.56912281
152Peritonitis (HP:0002586)1.55716090
153Hyperparathyroidism (HP:0000843)1.55484098
154Bowel incontinence (HP:0002607)1.54219908
155Amyloidosis (HP:0011034)1.53279273
156Deep palmar crease (HP:0006191)1.52351103
157Colitis (HP:0002583)1.52001067
158Dislocated radial head (HP:0003083)1.51037346
159Distal lower limb muscle weakness (HP:0009053)1.50940718
160Interstitial pulmonary disease (HP:0006530)1.50829191
161Abnormality of skeletal muscle fiber size (HP:0012084)1.50798585
162Distal sensory impairment (HP:0002936)1.49509977
163Thoracic kyphosis (HP:0002942)1.49209282
164Germ cell neoplasia (HP:0100728)1.49156915
165Atrophic scars (HP:0001075)1.48850690
166Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.48833737
167Hammertoe (HP:0001765)1.48607869
168Difficulty climbing stairs (HP:0003551)1.48550623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.28979708
2EPHA43.02598136
3TRIB32.93626330
4NTRK32.80902567
5MARK12.75449862
6PRKD32.72768347
7KSR22.67670449
8SMG12.58577201
9PAK62.57520131
10DAPK22.53430830
11ERN12.37718895
12PKN22.30345630
13CAMKK12.26000131
14MINK12.21675278
15TYRO32.12382903
16TAOK12.09403923
17SIK12.07747154
18ALK2.02194206
19FGFR42.00552280
20RIPK11.98431845
21MAP3K41.97918954
22SIK21.92894014
23LATS21.86771861
24NTRK11.85319640
25EEF2K1.67375623
26NTRK21.65914455
27KSR11.62783032
28STK381.59007702
29MAP2K31.50303068
30MAP3K101.48331185
31IRAK31.45640051
32ICK1.39653561
33MAP4K11.36046225
34MAP3K21.35588459
35DAPK11.31548614
36PDGFRA1.30069754
37MAP2K41.28037379
38RET1.27287299
39CDK51.26095203
40SCYL21.23352251
41ARAF1.15393416
42CDK121.12861506
43RIPK41.11729855
44PRKCH1.10385297
45STK111.10284728
46NEK11.09797723
47DDR21.08763316
48TAOK21.07953464
49EPHB11.07628813
50BMX1.04966658
51MAP3K111.04799077
52UHMK11.03884920
53ZAP701.02507807
54MAP3K30.94689980
55TYK20.89934001
56MARK20.88158433
57GRK50.87610632
58FGFR30.85358014
59IRAK40.84247256
60CDK150.82355317
61MAP3K140.82106153
62CSK0.81671720
63IRAK20.80902680
64PDK10.79811080
65LMTK20.79691105
66MAPK120.78944439
67CAMK1G0.78274891
68MAP3K70.77890085
69CDK180.77637447
70SIK30.75099684
71CDK140.73993154
72PHKG20.73805883
73PHKG10.73805883
74FES0.73564198
75JAK10.72891311
76CDK11A0.72823220
77PTK60.72577682
78SGK30.71676853
79MAP3K130.71023001
80PAK40.70951301
81JAK30.70568150
82BLK0.69716191
83DMPK0.69241480
84GRK60.68051261
85RAF10.66959052
86PDPK10.66018627
87PRKCG0.65894841
88PAK30.64780673
89HIPK20.63792094
90MAP2K70.63073431
91EPHA20.62420939
92RPS6KC10.59946248
93RPS6KL10.59946248
94CDC42BPA0.59368572
95MAP3K10.57396444
96BRAF0.55730442
97MAP3K60.55069479
98TESK10.54735571
99BRSK10.54660005
100PRKG20.54659118
101PRPF4B0.54335720
102HCK0.54187003
103TBK10.53266023
104CAMK10.52455785
105MTOR0.52240632
106MAPK100.51521156
107PDGFRB0.51119617
108DAPK30.50922867
109RPS6KA30.48637450
110MOS0.48484177
111FYN0.48245892
112TESK20.47993599
113BRD40.47789531
114CAMK40.47773294
115MAP2K20.46768877
116CDK60.46744872
117MAP3K80.46730513
118PRKCZ0.46127805
119RPS6KA20.45441546
120CDK40.44974857
121PTK20.44900876
122MAPK110.44637356
123SGK10.43891366
124PLK20.43094753
125FGFR20.42911614
126MAPK70.42600002
127CDK190.41179253
128CSNK1G20.41107410
129FGR0.40659153
130WNK10.40293287
131FGFR10.39239418
132CAMK1D0.38766672
133PRKD20.36881284
134MAPK80.36803732
135CSNK1E0.36796483
136PNCK0.36100539
137JAK20.35073525
138PTK2B0.35046156
139TNK20.34611003
140PAK20.34261501
141MAP2K10.33691946
142MAPK130.33414460
143CSNK1D0.32625636
144TTN0.32333899

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.36843975
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27320714
3Olfactory transduction_Homo sapiens_hsa047402.24648940
4Long-term potentiation_Homo sapiens_hsa047202.23015344
5Nitrogen metabolism_Homo sapiens_hsa009102.13116207
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95853805
7Circadian entrainment_Homo sapiens_hsa047131.91186595
8Glutamatergic synapse_Homo sapiens_hsa047241.80492930
9Nicotine addiction_Homo sapiens_hsa050331.77910068
10GABAergic synapse_Homo sapiens_hsa047271.77149032
11Acute myeloid leukemia_Homo sapiens_hsa052211.70753964
12Amphetamine addiction_Homo sapiens_hsa050311.70541967
13Dopaminergic synapse_Homo sapiens_hsa047281.69592376
14Salivary secretion_Homo sapiens_hsa049701.66146292
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65109102
16Gastric acid secretion_Homo sapiens_hsa049711.64537967
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64421843
18Glioma_Homo sapiens_hsa052141.63746559
19Morphine addiction_Homo sapiens_hsa050321.62266337
20Cholinergic synapse_Homo sapiens_hsa047251.58210176
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53369747
22Other glycan degradation_Homo sapiens_hsa005111.50348471
23GnRH signaling pathway_Homo sapiens_hsa049121.48130689
24Insulin secretion_Homo sapiens_hsa049111.48009292
25Oxytocin signaling pathway_Homo sapiens_hsa049211.46364114
26mTOR signaling pathway_Homo sapiens_hsa041501.45825503
27Estrogen signaling pathway_Homo sapiens_hsa049151.43150698
28Osteoclast differentiation_Homo sapiens_hsa043801.42733510
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39539954
30Type II diabetes mellitus_Homo sapiens_hsa049301.38502078
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36530065
32Gap junction_Homo sapiens_hsa045401.36179846
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32809491
34Notch signaling pathway_Homo sapiens_hsa043301.31687722
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.26950628
36ErbB signaling pathway_Homo sapiens_hsa040121.25328207
37VEGF signaling pathway_Homo sapiens_hsa043701.24438811
38Dorso-ventral axis formation_Homo sapiens_hsa043201.23874430
39Renin secretion_Homo sapiens_hsa049241.23295447
40Long-term depression_Homo sapiens_hsa047301.22762485
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21862379
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19638240
43Cocaine addiction_Homo sapiens_hsa050301.18123624
44Endometrial cancer_Homo sapiens_hsa052131.16514962
45Non-small cell lung cancer_Homo sapiens_hsa052231.16019815
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14978906
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12398890
48Leishmaniasis_Homo sapiens_hsa051401.10067276
49Melanogenesis_Homo sapiens_hsa049161.08525814
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.08322932
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.07291798
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06690681
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05956598
54Oocyte meiosis_Homo sapiens_hsa041141.05419841
55Axon guidance_Homo sapiens_hsa043601.01268568
56cAMP signaling pathway_Homo sapiens_hsa040241.01027141
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98274525
58Hepatitis B_Homo sapiens_hsa051610.98110856
59Calcium signaling pathway_Homo sapiens_hsa040200.97762274
60Chronic myeloid leukemia_Homo sapiens_hsa052200.95431863
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94342991
62Amoebiasis_Homo sapiens_hsa051460.93711590
63Tuberculosis_Homo sapiens_hsa051520.93403015
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93041357
65Colorectal cancer_Homo sapiens_hsa052100.92940938
66Renal cell carcinoma_Homo sapiens_hsa052110.91762366
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91613788
68Hepatitis C_Homo sapiens_hsa051600.90744928
69Toxoplasmosis_Homo sapiens_hsa051450.90685341
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89719990
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89065398
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.88667921
73Choline metabolism in cancer_Homo sapiens_hsa052310.87605045
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87418584
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87285143
76MAPK signaling pathway_Homo sapiens_hsa040100.86667164
77Endocytosis_Homo sapiens_hsa041440.85965263
78TNF signaling pathway_Homo sapiens_hsa046680.83448050
79Influenza A_Homo sapiens_hsa051640.83153119
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83055802
81Rap1 signaling pathway_Homo sapiens_hsa040150.82804887
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82626544
83HIF-1 signaling pathway_Homo sapiens_hsa040660.80879385
84Insulin signaling pathway_Homo sapiens_hsa049100.80353522
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79232234
86Apoptosis_Homo sapiens_hsa042100.77707487
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77119255
88Prostate cancer_Homo sapiens_hsa052150.75986006
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75734498
90Taste transduction_Homo sapiens_hsa047420.75545985
91Shigellosis_Homo sapiens_hsa051310.75306147
92Glucagon signaling pathway_Homo sapiens_hsa049220.73486252
93Adherens junction_Homo sapiens_hsa045200.73477092
94Salmonella infection_Homo sapiens_hsa051320.73058060
95MicroRNAs in cancer_Homo sapiens_hsa052060.71632383
96Thyroid hormone synthesis_Homo sapiens_hsa049180.71535521
97Proteoglycans in cancer_Homo sapiens_hsa052050.71421404
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.71196652
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.70960137
100Dilated cardiomyopathy_Homo sapiens_hsa054140.70451939
101Hippo signaling pathway_Homo sapiens_hsa043900.68595632
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68164617
103Small cell lung cancer_Homo sapiens_hsa052220.68039200
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.67389115
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.67379601
106Prolactin signaling pathway_Homo sapiens_hsa049170.67177252
107Chemokine signaling pathway_Homo sapiens_hsa040620.66180090
108Bile secretion_Homo sapiens_hsa049760.65953410
109Serotonergic synapse_Homo sapiens_hsa047260.65554005
110Measles_Homo sapiens_hsa051620.65192195
111AMPK signaling pathway_Homo sapiens_hsa041520.63955434
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63647134
113Wnt signaling pathway_Homo sapiens_hsa043100.62076202
114Platelet activation_Homo sapiens_hsa046110.61459350
115B cell receptor signaling pathway_Homo sapiens_hsa046620.61163998
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60396310
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.58842866
118FoxO signaling pathway_Homo sapiens_hsa040680.58642335
119Inositol phosphate metabolism_Homo sapiens_hsa005620.57891135
120Pancreatic cancer_Homo sapiens_hsa052120.57601116
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57027048
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56823523
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56759674
124Ras signaling pathway_Homo sapiens_hsa040140.56573594
125Bladder cancer_Homo sapiens_hsa052190.56380908
126HTLV-I infection_Homo sapiens_hsa051660.55648703
127Viral carcinogenesis_Homo sapiens_hsa052030.55480702
128Insulin resistance_Homo sapiens_hsa049310.55476948
129Focal adhesion_Homo sapiens_hsa045100.54974200
130T cell receptor signaling pathway_Homo sapiens_hsa046600.54825033
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54613697
132Prion diseases_Homo sapiens_hsa050200.53453550
133Pancreatic secretion_Homo sapiens_hsa049720.53213108
134Thyroid cancer_Homo sapiens_hsa052160.51758855

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