AUH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.41994478
2negative regulation of norepinephrine secretion (GO:0010700)4.30348762
3regulation of sulfur metabolic process (GO:0042762)4.22777263
4C4-dicarboxylate transport (GO:0015740)4.06076030
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02895059
6short-chain fatty acid metabolic process (GO:0046459)3.96549750
7fatty acid beta-oxidation (GO:0006635)3.85289755
8carnitine shuttle (GO:0006853)3.76944542
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.68776798
10L-phenylalanine metabolic process (GO:0006558)3.68776798
11dopamine transport (GO:0015872)3.68232745
12regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.67549764
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.61435271
14L-phenylalanine catabolic process (GO:0006559)3.61435271
15succinate metabolic process (GO:0006105)3.54163422
16L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.52429296
17fatty acid transmembrane transport (GO:1902001)3.49325675
18lysine metabolic process (GO:0006553)3.47059703
19lysine catabolic process (GO:0006554)3.47059703
20respiratory electron transport chain (GO:0022904)3.44519156
21amino acid salvage (GO:0043102)3.41378553
22L-methionine salvage (GO:0071267)3.41378553
23L-methionine biosynthetic process (GO:0071265)3.41378553
24cellular ketone body metabolic process (GO:0046950)3.41212527
25* branched-chain amino acid metabolic process (GO:0009081)3.39091322
26fatty acid catabolic process (GO:0009062)3.38735423
27fatty acid oxidation (GO:0019395)3.38428992
28regulation of mitochondrial translation (GO:0070129)3.36183902
29valine metabolic process (GO:0006573)3.36089131
30* branched-chain amino acid catabolic process (GO:0009083)3.35240475
31tricarboxylic acid cycle (GO:0006099)3.33977505
32regulation of cholesterol esterification (GO:0010872)3.33909609
33short-term memory (GO:0007614)3.33651662
34lipid oxidation (GO:0034440)3.33414597
35electron transport chain (GO:0022900)3.32965697
36regulation of glucokinase activity (GO:0033131)3.31254247
37regulation of hexokinase activity (GO:1903299)3.31254247
38regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.31169178
39regulation of sequestering of triglyceride (GO:0010889)3.29634762
40regulation of relaxation of muscle (GO:1901077)3.27070198
41regulation of cell communication by electrical coupling (GO:0010649)3.24113621
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.20088603
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.17716516
44actin-myosin filament sliding (GO:0033275)3.16687400
45muscle filament sliding (GO:0030049)3.16687400
46biotin metabolic process (GO:0006768)3.15350764
47very-low-density lipoprotein particle assembly (GO:0034379)3.14723449
48potassium ion export (GO:0071435)3.13688784
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.10077650
50aromatic amino acid family catabolic process (GO:0009074)3.08032635
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06563782
52gluconeogenesis (GO:0006094)3.06292854
53NADH metabolic process (GO:0006734)3.06109856
54negative regulation of catecholamine secretion (GO:0033604)3.05817746
55regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01780142
56peripheral nervous system neuron development (GO:0048935)3.01587445
57monocarboxylic acid catabolic process (GO:0072329)3.01322341
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96578705
592-oxoglutarate metabolic process (GO:0006103)2.95738762
60regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.92924689
61amino-acid betaine transport (GO:0015838)2.90373234
62carnitine transport (GO:0015879)2.90373234
63positive regulation of cellular amine metabolic process (GO:0033240)2.89595560
64carnitine transmembrane transport (GO:1902603)2.87838970
65hexose biosynthetic process (GO:0019319)2.87775216
66negative regulation of heart rate (GO:0010459)2.87362876
674-hydroxyproline metabolic process (GO:0019471)2.84704111
68adrenergic receptor signaling pathway (GO:0071875)2.84353479
69detection of calcium ion (GO:0005513)2.82248027
70ketone body metabolic process (GO:1902224)2.81567305
71water-soluble vitamin biosynthetic process (GO:0042364)2.79551816
72oxidative demethylation (GO:0070989)2.77212306
73creatine metabolic process (GO:0006600)2.76278738
74quinone biosynthetic process (GO:1901663)2.76159062
75ubiquinone biosynthetic process (GO:0006744)2.76159062
76aspartate family amino acid catabolic process (GO:0009068)2.72407831
77acetyl-CoA metabolic process (GO:0006084)2.71002564
78cardiac muscle contraction (GO:0060048)2.69167005
79oxaloacetate metabolic process (GO:0006107)2.68656441
80protein complex biogenesis (GO:0070271)2.68212378
81positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67594737
82relaxation of muscle (GO:0090075)2.67347655
83fatty acid homeostasis (GO:0055089)2.66093070
84neurotransmitter uptake (GO:0001504)2.65993613
85methionine biosynthetic process (GO:0009086)2.65633790
86regulation of coenzyme metabolic process (GO:0051196)2.64117016
87regulation of cofactor metabolic process (GO:0051193)2.64117016
88dicarboxylic acid catabolic process (GO:0043649)2.63417910
89tryptophan catabolic process (GO:0006569)2.63145534
90indole-containing compound catabolic process (GO:0042436)2.63145534
91indolalkylamine catabolic process (GO:0046218)2.63145534
92quaternary ammonium group transport (GO:0015697)2.62795253
93striated muscle contraction (GO:0006941)2.62414883
94regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62330180
95single strand break repair (GO:0000012)2.61443206
96cardiac myofibril assembly (GO:0055003)2.60358239
97aerobic respiration (GO:0009060)2.59972006
98G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.59822277
99regulation of protein activation cascade (GO:2000257)2.59603115
100glycogen catabolic process (GO:0005980)2.58187997
101response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.57478551
102actin-mediated cell contraction (GO:0070252)2.55819670
103oxidative phosphorylation (GO:0006119)2.55495095
104nitrogen cycle metabolic process (GO:0071941)2.55070376
105methionine metabolic process (GO:0006555)2.54905616
106regulation of actin filament-based movement (GO:1903115)2.54887463
107neurofilament cytoskeleton organization (GO:0060052)2.53619162
108transcription from mitochondrial promoter (GO:0006390)2.53585957
109nonribosomal peptide biosynthetic process (GO:0019184)2.53113995
110myofibril assembly (GO:0030239)2.52969311
111regulation of complement activation (GO:0030449)2.52580793
112alkaloid metabolic process (GO:0009820)2.51989617
113negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.51916315
114cardiac muscle hypertrophy (GO:0003300)2.51749838
115serine family amino acid catabolic process (GO:0009071)2.51231481
116regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.51029996
117tricarboxylic acid metabolic process (GO:0072350)2.50992467
118glutathione biosynthetic process (GO:0006750)2.50185944
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50164049
120mitochondrial respiratory chain complex I assembly (GO:0032981)2.50164049
121NADH dehydrogenase complex assembly (GO:0010257)2.50164049
122NAD metabolic process (GO:0019674)2.49594804
123tryptophan metabolic process (GO:0006568)2.49441830
124positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47406656
125neuronal action potential propagation (GO:0019227)2.46650227
126pyrimidine ribonucleoside catabolic process (GO:0046133)2.46497395
127eating behavior (GO:0042755)2.46494454
128coenzyme catabolic process (GO:0009109)2.46264741
129negative regulation of cAMP-mediated signaling (GO:0043951)2.45945943
130* carboxylic acid catabolic process (GO:0046395)2.45155155
131* organic acid catabolic process (GO:0016054)2.45155155
132positive regulation of glycolytic process (GO:0045821)2.45119149
133sarcomere organization (GO:0045214)2.44699723
134arginine metabolic process (GO:0006525)2.44181824
135pyruvate metabolic process (GO:0006090)2.42948045
136negative regulation of dendrite morphogenesis (GO:0050774)2.42859065
137lactate metabolic process (GO:0006089)2.42589823
138monosaccharide biosynthetic process (GO:0046364)2.42149907
139aromatic amino acid family metabolic process (GO:0009072)2.41323354
140peptide biosynthetic process (GO:0043043)2.39721525
141negative regulation of calcium ion transport into cytosol (GO:0010523)2.39463045
142striated muscle hypertrophy (GO:0014897)2.39095156
143positive regulation of mitochondrial fission (GO:0090141)2.38891907
144aspartate family amino acid biosynthetic process (GO:0009067)2.38407802
145aminoglycoside antibiotic metabolic process (GO:0030647)2.37663011
146glucan catabolic process (GO:0009251)2.37496792
147sarcoplasmic reticulum calcium ion transport (GO:0070296)2.36590027
148drug transmembrane transport (GO:0006855)2.36562648
149glycogen biosynthetic process (GO:0005978)2.36419698
150glucan biosynthetic process (GO:0009250)2.36419698
151enteric nervous system development (GO:0048484)2.35096524
152glyoxylate metabolic process (GO:0046487)2.34666861
153tyrosine metabolic process (GO:0006570)2.34347721
154cellular sodium ion homeostasis (GO:0006883)2.33009419
155positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.32817209
156cell communication involved in cardiac conduction (GO:0086065)2.32554270
157ventricular cardiac muscle cell action potential (GO:0086005)2.32300166
158NAD biosynthetic process (GO:0009435)2.31048994
159phenylpropanoid metabolic process (GO:0009698)2.30993431
160low-density lipoprotein particle remodeling (GO:0034374)2.30312621
161ubiquinone metabolic process (GO:0006743)2.30269984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90962879
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.28028397
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.85641545
4GBX2_23144817_ChIP-Seq_PC3_Human2.85536324
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.80146908
6EZH2_22144423_ChIP-Seq_EOC_Human2.40271632
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.39587776
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39173628
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29463151
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.27333813
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.17955709
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13635256
13GATA1_22025678_ChIP-Seq_K562_Human2.11993322
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09329936
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97394159
16* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95634619
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94074315
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84462907
19TAF15_26573619_Chip-Seq_HEK293_Human1.83001802
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75984400
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.74431873
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74181375
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.72455788
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71814198
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70458688
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67423603
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65942590
28IGF1R_20145208_ChIP-Seq_DFB_Human1.63209512
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61951083
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59751381
31VDR_22108803_ChIP-Seq_LS180_Human1.59598192
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59529321
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59179328
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59116435
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54742574
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54642162
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.52429500
38ZNF263_19887448_ChIP-Seq_K562_Human1.50624045
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50132021
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49437320
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48378804
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46667400
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44999976
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44354421
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41121558
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39237890
47FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.37287239
48AR_21572438_ChIP-Seq_LNCaP_Human1.36596707
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36516029
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.36047666
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.35145013
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34817899
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33001679
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32917225
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32584680
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32584680
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31490199
58REST_21632747_ChIP-Seq_MESCs_Mouse1.31033671
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.30976687
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.28757667
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26328374
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24622912
63* SMAD4_21799915_ChIP-Seq_A2780_Human1.23839678
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23411485
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22404158
66* TCF4_23295773_ChIP-Seq_U87_Human1.21652811
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21635470
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21519555
69SCL_19346495_ChIP-Seq_HPC-7_Human1.21038937
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.19962459
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19859882
72* P300_19829295_ChIP-Seq_ESCs_Human1.18891990
73DROSHA_22980978_ChIP-Seq_HELA_Human1.18462777
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18387935
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18119162
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16905709
77IRF1_19129219_ChIP-ChIP_H3396_Human1.16392501
78HNF4A_19822575_ChIP-Seq_HepG2_Human1.15331658
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15181255
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14236834
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13990939
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13701227
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12827327
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12773754
85TP53_22573176_ChIP-Seq_HFKS_Human1.12703045
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11311485
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11006553
88TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10588508
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10528628
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.09759768
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.09075538
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.08811557
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.07687257
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.06052161
95BCAT_22108803_ChIP-Seq_LS180_Human1.06004623
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.04870429
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.04691363
98* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04598628
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03259921
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02633241
101P53_22387025_ChIP-Seq_ESCs_Mouse1.02530906
102CBP_20019798_ChIP-Seq_JUKART_Human1.02103327
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02103327
104FUS_26573619_Chip-Seq_HEK293_Human1.01156073
105* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98604679
106* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97736528
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97673232
108STAT3_23295773_ChIP-Seq_U87_Human0.97644363
109SOX2_18555785_Chip-Seq_ESCs_Mouse0.97607906
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97417245
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97362123
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97176131
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96880870
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96522145
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.96022571
116NMYC_18555785_Chip-Seq_ESCs_Mouse0.94938666
117P300_18555785_Chip-Seq_ESCs_Mouse0.94609167
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94515645
119RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93826759
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93725555
121TAL1_26923725_Chip-Seq_HPCs_Mouse0.93693983
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93685234
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.93205714
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92910765
125HTT_18923047_ChIP-ChIP_STHdh_Human0.92655102
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92477979
127RNF2_27304074_Chip-Seq_NSC_Mouse0.91427901
128CTCF_18555785_Chip-Seq_ESCs_Mouse0.90888670
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90862390
130TCF4_22108803_ChIP-Seq_LS180_Human0.90557916
131* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90518319
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90286801
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89967636
134KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89709507
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.89501702
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89139414
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.89020768
138* FLI1_21867929_ChIP-Seq_TH2_Mouse0.88563667
139KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87796162
140EED_16625203_ChIP-ChIP_MESCs_Mouse0.87545647
141AR_25329375_ChIP-Seq_VCAP_Human0.87424136
142CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87175555
143* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87142268
144CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85626924
145ESRRB_18555785_Chip-Seq_ESCs_Mouse0.85534482
146KLF4_18555785_Chip-Seq_ESCs_Mouse0.85427431
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.85267173
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84728726
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84603410
150LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83996935
151PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83541187
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.83118128
153* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82986539
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82903149
155* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82769684
156ZFX_18555785_Chip-Seq_ESCs_Mouse0.82745428
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.82481221
158NANOG_19829295_ChIP-Seq_ESCs_Human0.82208915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.88735486
2MP0002837_dystrophic_cardiac_calcinosis3.81786066
3MP0005365_abnormal_bile_salt2.71228930
4MP0005085_abnormal_gallbladder_physiolo2.64800386
5MP0005360_urolithiasis2.59935764
6MP0003122_maternal_imprinting2.57411741
7MP0002139_abnormal_hepatobiliary_system2.53723356
8MP0005670_abnormal_white_adipose2.45961505
9MP0000751_myopathy2.21731675
10MP0000749_muscle_degeneration2.19394254
11MP0006036_abnormal_mitochondrial_physio2.16658215
12MP0003567_abnormal_fetal_cardiomyocyte2.09653355
13MP0008877_abnormal_DNA_methylation2.02662835
14MP0004145_abnormal_muscle_electrophysio2.01466112
15MP0004147_increased_porphyrin_level1.98197051
16MP0002822_catalepsy1.90214580
17MP0003787_abnormal_imprinting1.89467309
18MP0004215_abnormal_myocardial_fiber1.89448477
19MP0004036_abnormal_muscle_relaxation1.85564060
20MP0003195_calcinosis1.84637040
21MP0006276_abnormal_autonomic_nervous1.79061053
22MP0005083_abnormal_biliary_tract1.79052718
23MP0001666_abnormal_nutrient_absorption1.77462621
24MP0004142_abnormal_muscle_tone1.76820063
25MP0006035_abnormal_mitochondrial_morpho1.76436163
26MP0004130_abnormal_muscle_cell1.76340040
27MP0005332_abnormal_amino_acid1.74196430
28MP0003123_paternal_imprinting1.73095050
29MP0008875_abnormal_xenobiotic_pharmacok1.71604718
30MP0004510_myositis1.68339382
31MP0004270_analgesia1.66502721
32MP0003880_abnormal_central_pattern1.63825586
33MP0001188_hyperpigmentation1.57813206
34MP0005330_cardiomyopathy1.56413737
35MP0003656_abnormal_erythrocyte_physiolo1.54073490
36MP0005535_abnormal_body_temperature1.53311610
37MP0001984_abnormal_olfaction1.49539179
38MP0001661_extended_life_span1.45852769
39MP0005646_abnormal_pituitary_gland1.45332615
40MP0002638_abnormal_pupillary_reflex1.45062016
41MP0005451_abnormal_body_composition1.42831746
42MP0004084_abnormal_cardiac_muscle1.40934145
43MP0005645_abnormal_hypothalamus_physiol1.40051761
44MP0002735_abnormal_chemical_nociception1.37450412
45MP0006292_abnormal_olfactory_placode1.37225449
46MP0008057_abnormal_DNA_replication1.36802494
47MP0003137_abnormal_impulse_conducting1.36155245
48MP0003879_abnormal_hair_cell1.34611156
49MP0002163_abnormal_gland_morphology1.34244943
50MP0003186_abnormal_redox_activity1.32498876
51MP0002876_abnormal_thyroid_physiology1.32331147
52MP0004859_abnormal_synaptic_plasticity1.31529978
53MP0001986_abnormal_taste_sensitivity1.31367735
54MP0004043_abnormal_pH_regulation1.29503703
55MP0003868_abnormal_feces_composition1.28336093
56MP0002078_abnormal_glucose_homeostasis1.27990954
57MP0001544_abnormal_cardiovascular_syste1.27262201
58MP0005385_cardiovascular_system_phenoty1.27262201
59MP0004484_altered_response_of1.26582424
60MP0009697_abnormal_copulation1.26250597
61MP0001502_abnormal_circadian_rhythm1.25923976
62MP0003121_genomic_imprinting1.25679347
63MP0002118_abnormal_lipid_homeostasis1.23121111
64MP0009745_abnormal_behavioral_response1.23032209
65MP0005379_endocrine/exocrine_gland_phen1.22211567
66MP0008775_abnormal_heart_ventricle1.22103772
67MP0002972_abnormal_cardiac_muscle1.19224244
68MP0001501_abnormal_sleep_pattern1.18550543
69MP0002909_abnormal_adrenal_gland1.16895079
70MP0005620_abnormal_muscle_contractility1.15115261
71MP0002734_abnormal_mechanical_nocicepti1.14367539
72MP0002067_abnormal_sensory_capabilities1.13231554
73MP0000747_muscle_weakness1.12912384
74MP0005075_abnormal_melanosome_morpholog1.12840150
75MP0003221_abnormal_cardiomyocyte_apopto1.11651188
76MP0002269_muscular_atrophy1.11269742
77MP0005171_absent_coat_pigmentation1.10969281
78MP0002272_abnormal_nervous_system1.10713144
79MP0002971_abnormal_brown_adipose1.10627621
80MP0000015_abnormal_ear_pigmentation1.10015110
81MP0001764_abnormal_homeostasis1.10002069
82MP0001486_abnormal_startle_reflex1.08756107
83MP0004085_abnormal_heartbeat1.06011844
84MP0001970_abnormal_pain_threshold1.04926439
85MP0005334_abnormal_fat_pad1.04704049
86MP0005636_abnormal_mineral_homeostasis1.03996846
87MP0003252_abnormal_bile_duct1.01892523
88MP0002106_abnormal_muscle_physiology1.01803183
89MP0010329_abnormal_lipoprotein_level1.01750180
90MP0006072_abnormal_retinal_apoptosis1.00413026
91MP0005584_abnormal_enzyme/coenzyme_acti0.99469962
92MP0000230_abnormal_systemic_arterial0.98842318
93MP0001529_abnormal_vocalization0.96452446
94MP0008995_early_reproductive_senescence0.95269691
95MP0003806_abnormal_nucleotide_metabolis0.95236334
96MP0002733_abnormal_thermal_nociception0.95135732
97MP0004087_abnormal_muscle_fiber0.94869849
98MP0005666_abnormal_adipose_tissue0.93642464
99MP0006138_congestive_heart_failure0.93118926
100MP0005386_behavior/neurological_phenoty0.92506486
101MP0004924_abnormal_behavior0.92506486
102MP0000639_abnormal_adrenal_gland0.92421729
103MP0005266_abnormal_metabolism0.92091950
104MP0002127_abnormal_cardiovascular_syste0.91799178
105MP0002009_preneoplasia0.90858193
106MP0003045_fibrosis0.88735030
107MP0003191_abnormal_cellular_cholesterol0.88217042
108MP0000759_abnormal_skeletal_muscle0.87772864
109MP0002332_abnormal_exercise_endurance0.87762662
110MP0008874_decreased_physiological_sensi0.87008203
111MP0005174_abnormal_tail_pigmentation0.86692512
112MP0010630_abnormal_cardiac_muscle0.86465173
113MP0001765_abnormal_ion_homeostasis0.86237188
114MP0002229_neurodegeneration0.85862306
115MP0002064_seizures0.85734403
116MP0001905_abnormal_dopamine_level0.85552442
117MP0002693_abnormal_pancreas_physiology0.84039030
118MP0005084_abnormal_gallbladder_morpholo0.83339594
119MP0002063_abnormal_learning/memory/cond0.83176753
120MP0002184_abnormal_innervation0.83045280
121MP0009643_abnormal_urine_homeostasis0.81883779
122MP0010386_abnormal_urinary_bladder0.80811214
123MP0001270_distended_abdomen0.80685516
124MP0005319_abnormal_enzyme/_coenzyme0.80202025
125MP0001968_abnormal_touch/_nociception0.80151646
126MP0003953_abnormal_hormone_level0.79093703
127MP0003635_abnormal_synaptic_transmissio0.78498906
128MP0005551_abnormal_eye_electrophysiolog0.76930284
129MP0009046_muscle_twitch0.76860617
130MP0005369_muscle_phenotype0.76749376
131MP0008569_lethality_at_weaning0.75811420
132MP0004019_abnormal_vitamin_homeostasis0.75640769

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)4.15234592
2Increased serum pyruvate (HP:0003542)4.02878764
3Ketoacidosis (HP:0001993)3.92616814
4Pheochromocytoma (HP:0002666)3.90146839
5Abnormality of glycolysis (HP:0004366)3.80730106
6Neuroendocrine neoplasm (HP:0100634)3.77225745
7Hepatic necrosis (HP:0002605)3.70007234
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.62754126
9Ketosis (HP:0001946)3.57573146
10Abnormal mitochondria in muscle tissue (HP:0008316)3.48925621
11Acute necrotizing encephalopathy (HP:0006965)3.46785440
12Acute encephalopathy (HP:0006846)3.46489103
13Hypoglycemic coma (HP:0001325)3.35616983
14Hepatocellular necrosis (HP:0001404)3.26118711
15Myokymia (HP:0002411)3.25952386
16Abnormality of fatty-acid metabolism (HP:0004359)3.19086691
17Mitochondrial inheritance (HP:0001427)3.10133662
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.07298389
19Dicarboxylic aciduria (HP:0003215)3.07298389
20Conjugated hyperbilirubinemia (HP:0002908)3.00790935
21Exercise-induced myalgia (HP:0003738)3.00652551
22Cerebral edema (HP:0002181)3.00365747
23Generalized aminoaciduria (HP:0002909)3.00095302
24Myoglobinuria (HP:0002913)2.99044889
25Increased muscle lipid content (HP:0009058)2.95689909
26Palpitations (HP:0001962)2.89438964
27Progressive macrocephaly (HP:0004481)2.87613660
28Atrial fibrillation (HP:0005110)2.85769793
29Increased CSF lactate (HP:0002490)2.84720053
30Muscle fiber inclusion bodies (HP:0100299)2.84083695
31Lactic acidosis (HP:0003128)2.83735962
32Hyperglycinuria (HP:0003108)2.81374664
33Abnormality of alanine metabolism (HP:0010916)2.79086290
34Hyperalaninemia (HP:0003348)2.79086290
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79086290
36Increased intramyocellular lipid droplets (HP:0012240)2.78565900
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77273341
38Myotonia (HP:0002486)2.75198238
39Nemaline bodies (HP:0003798)2.71176807
40Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.68685024
41Hyperammonemia (HP:0001987)2.68603171
42Sudden death (HP:0001699)2.68057138
43Renal cortical cysts (HP:0000803)2.67590164
44Scanning speech (HP:0002168)2.66688921
45Primary atrial arrhythmia (HP:0001692)2.61430279
46Hyperglycinemia (HP:0002154)2.58390520
47Prolonged QT interval (HP:0001657)2.54053360
48Prolonged partial thromboplastin time (HP:0003645)2.52916287
49Impaired vibration sensation in the lower limbs (HP:0002166)2.50756341
50Supraventricular tachycardia (HP:0004755)2.46776804
51Muscle hypertrophy of the lower extremities (HP:0008968)2.46044288
52Nonprogressive disorder (HP:0003680)2.44453935
53Hypothermia (HP:0002045)2.42599220
54* Febrile seizures (HP:0002373)2.42401050
55Lethargy (HP:0001254)2.41857056
56Absence seizures (HP:0002121)2.41451887
57Proximal tubulopathy (HP:0000114)2.40911950
58Calf muscle hypertrophy (HP:0008981)2.40852087
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40282513
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.40282513
613-Methylglutaconic aciduria (HP:0003535)2.40149525
62Abnormality of glycine metabolism (HP:0010895)2.38969142
63Abnormality of serine family amino acid metabolism (HP:0010894)2.38969142
64Asymmetric septal hypertrophy (HP:0001670)2.35948629
65Intrahepatic cholestasis (HP:0001406)2.34720823
66Rimmed vacuoles (HP:0003805)2.34424119
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33666067
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33666067
69Supraventricular arrhythmia (HP:0005115)2.31780437
70* Metabolic acidosis (HP:0001942)2.30542881
71Lipid accumulation in hepatocytes (HP:0006561)2.30437613
72Hypobetalipoproteinemia (HP:0003563)2.29761003
73Syncope (HP:0001279)2.27251924
74Right ventricular cardiomyopathy (HP:0011663)2.26316004
75Exercise intolerance (HP:0003546)2.22955630
76Atonic seizures (HP:0010819)2.22357563
77Optic disc pallor (HP:0000543)2.21564160
78Hypoglycemic seizures (HP:0002173)2.19798081
79Heart block (HP:0012722)2.15804223
80Papillary thyroid carcinoma (HP:0002895)2.12793573
81Microvesicular hepatic steatosis (HP:0001414)2.12334193
82Methylmalonic aciduria (HP:0012120)2.11326177
83Abnormality of urine glucose concentration (HP:0011016)2.10396653
84Glycosuria (HP:0003076)2.10396653
85Left ventricular hypertrophy (HP:0001712)2.09707527
86Hyperactive renin-angiotensin system (HP:0000841)2.09702892
87Dialeptic seizures (HP:0011146)2.07853935
88Bundle branch block (HP:0011710)2.07326483
89Increased hepatocellular lipid droplets (HP:0006565)2.06879666
90Vomiting (HP:0002013)2.05820932
91Abnormal EKG (HP:0003115)2.05783633
92Oligomenorrhea (HP:0000876)2.05497451
93Abnormality of serum amino acid levels (HP:0003112)2.04866493
94Metabolic alkalosis (HP:0200114)2.04434877
95Dilated cardiomyopathy (HP:0001644)2.00453630
96Pancreatic islet-cell hyperplasia (HP:0004510)2.00412374
97Hyperinsulinemic hypoglycemia (HP:0000825)1.99408822
98Sensorimotor neuropathy (HP:0007141)1.99224011
99Large for gestational age (HP:0001520)1.98936547
100Hyporeflexia of lower limbs (HP:0002600)1.98877391
101Hypochromic microcytic anemia (HP:0004840)1.98186727
102Increased circulating renin level (HP:0000848)1.98052129
103Atrioventricular block (HP:0001678)1.97635805
104Renal Fanconi syndrome (HP:0001994)1.97146787
105Methylmalonic acidemia (HP:0002912)1.96300919
106Central scotoma (HP:0000603)1.95630041
107Respiratory failure (HP:0002878)1.95319678
108Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93992347
109Abnormality of the calf musculature (HP:0001430)1.92384900
110Abnormality of the corticospinal tract (HP:0002492)1.91676037
111Ragged-red muscle fibers (HP:0003200)1.90235787
112EMG: myopathic abnormalities (HP:0003458)1.89978784
113Focal motor seizures (HP:0011153)1.89639220
114Hyperaldosteronism (HP:0000859)1.89630678
115Acute hepatic failure (HP:0006554)1.89207626
116Muscle stiffness (HP:0003552)1.88625091
117Increased serum lactate (HP:0002151)1.88250908
118Poor speech (HP:0002465)1.87585451
119Insulin-resistant diabetes mellitus (HP:0000831)1.87313256
120Clitoromegaly (HP:0000057)1.86155814
121Hypomagnesemia (HP:0002917)1.85975992
122Hypercholesterolemia (HP:0003124)1.84783621
123Late onset (HP:0003584)1.84684817
124Abnormal atrioventricular conduction (HP:0005150)1.84419337
125Exertional dyspnea (HP:0002875)1.84238661
126Tinnitus (HP:0000360)1.82843201
127Alkalosis (HP:0001948)1.81368046
128Decreased circulating renin level (HP:0003351)1.81316159
129Gout (HP:0001997)1.81002745
130Rhabdomyolysis (HP:0003201)1.80754036
131Deep venous thrombosis (HP:0002625)1.80314598
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79293356
133Ventricular arrhythmia (HP:0004308)1.78007000
134Action tremor (HP:0002345)1.77037732
135Osteomalacia (HP:0002749)1.75480555
136Proximal amyotrophy (HP:0007126)1.75021672
137Abnormality of the left ventricular outflow tract (HP:0011103)1.74664391
138Subaortic stenosis (HP:0001682)1.74664391
139Hyperkalemia (HP:0002153)1.73810923
140Abnormality of endocrine pancreas physiology (HP:0012093)1.73754060
141Abnormality of the pancreatic islet cells (HP:0006476)1.73754060
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71585799
143Muscle fiber splitting (HP:0003555)1.71010038
144Termporal pattern (HP:0011008)1.69172726
145Insidious onset (HP:0003587)1.69172726
146Abnormality of calcium-phosphate metabolism (HP:0100530)1.68331143
147Abnormality of vitamin metabolism (HP:0100508)1.68047758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.54883180
2PINK13.93199870
3BMPR1B3.18306934
4CDK83.12784906
5INSRR2.77159893
6MAP3K62.69443113
7BCKDK2.64243213
8EPHA42.55432496
9STK162.28354707
10TRIM282.15277319
11MAPK152.04238601
12GRK51.96205727
13ARAF1.94850574
14PHKG11.94631513
15PHKG21.94631513
16MAPKAPK31.86845125
17NTRK31.66223881
18NEK11.64664428
19BCR1.62465822
20MAPKAPK51.61870402
21ACVR1B1.61442913
22MAP2K71.61441260
23MST41.55452809
24TXK1.55243659
25MAP3K111.54746354
26DYRK1B1.50120369
27CASK1.49993939
28CDK91.47804127
29EPHA31.46908371
30OBSCN1.43205137
31TAOK31.38263729
32ERBB31.37848476
33SGK21.33088832
34MAP3K121.32860096
35BMPR21.31103030
36TAOK11.30506729
37PRKD21.29962666
38WNK41.29220427
39AKT31.29040366
40CAMK41.28841645
41MAP3K131.28051139
42PAK31.26212013
43BRD41.22358125
44SRPK11.21842281
45SGK4941.18788618
46SGK2231.18788618
47UHMK11.18671564
48DMPK1.17665850
49BRAF1.15405576
50EIF2AK31.14091358
51HIPK21.13814426
52NTRK21.10594717
53FLT31.09116022
54LMTK21.06970737
55MYLK1.05837286
56PRPF4B1.03650357
57PRKAA21.02610334
58TESK21.01765026
59STK38L0.99820401
60MAP4K20.98768053
61TNK20.93153494
62TGFBR10.92918287
63DYRK30.91895506
64MAP2K40.91637597
65NUAK10.91478509
66MAPK130.90060275
67SGK30.89125500
68GRK70.88487730
69SIK30.87123921
70PDK20.86946437
71LATS10.85864355
72MINK10.85625570
73LATS20.85324959
74MAP3K50.85094958
75TTK0.83290779
76MAPK110.83166848
77TRPM70.82640821
78PRKAA10.82378205
79STK380.81203261
80NLK0.80350002
81CAMK2G0.79917302
82OXSR10.78916301
83CAMK2D0.78895895
84CSNK1G20.78640046
85TNIK0.78470667
86MAP3K10.73771910
87CSNK1A1L0.70541911
88CDK50.69456077
89CDK190.69148690
90MARK10.69144335
91RAF10.68755075
92YES10.68580967
93ICK0.68496850
94PIK3CA0.67701709
95WNK10.67646034
96TIE10.67053872
97TEC0.65729162
98CAMK1D0.65177567
99TTN0.65127866
100SCYL20.63778719
101RET0.62655959
102CSNK1G30.61747883
103WNK30.59922766
104ZAK0.59495281
105CAMKK20.59275137
106MARK20.58353439
107CAMK2A0.58071445
108PRKCG0.57540968
109STK390.55476305
110IRAK10.53032436
111PRKCQ0.52570101
112PRKG20.51413344
113CSNK1G10.51279140
114PBK0.50623643
115FER0.50413357
116PDK10.48347001
117PIM20.46740350
118PRKACG0.46699232
119GRK10.46585942
120FGFR10.45120410
121MAPK120.44960789
122SGK10.44797501
123PIK3CG0.44790511
124MAP2K60.44688791
125PRKACA0.44337568
126ADRBK20.44225949
127KSR20.44039026
128IRAK40.43882353
129KIT0.43765522
130CAMK2B0.43167400
131PRKD10.42953932
132MAP4K10.42843145
133CSNK1D0.42470631
134PKN10.41458719
135CAMK10.41172729
136PRKG10.41094540
137RPS6KA30.39931904
138SYK0.39322070
139DYRK1A0.39071376
140DAPK10.38700469
141RPS6KB10.38175020
142CSNK1A10.38173909
143PRKACB0.37988336
144MATK0.36647764
145PRKCE0.36532938
146ATM0.35992504
147JAK20.35458043
148DAPK20.35274629
149NEK90.34552006
150MAP3K40.33099400
151MAP3K90.32740593
152CSNK2A20.32448946
153KSR10.32359012
154MAP3K70.32321580
155CAMKK10.32203293

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.24811692
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.23369699
3* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.05045885
4Oxidative phosphorylation_Homo sapiens_hsa001902.90690520
5Parkinsons disease_Homo sapiens_hsa050122.76862986
6Fatty acid degradation_Homo sapiens_hsa000712.64002768
7Butanoate metabolism_Homo sapiens_hsa006502.28677002
8Cardiac muscle contraction_Homo sapiens_hsa042602.21239054
9Fatty acid metabolism_Homo sapiens_hsa012122.17840266
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12567425
11Alzheimers disease_Homo sapiens_hsa050102.10090121
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06086625
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.99922125
14Peroxisome_Homo sapiens_hsa041461.98952019
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95950489
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94768538
17Fatty acid elongation_Homo sapiens_hsa000621.94729943
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.90549242
19Pyruvate metabolism_Homo sapiens_hsa006201.87287269
20Tryptophan metabolism_Homo sapiens_hsa003801.86874367
21Vitamin B6 metabolism_Homo sapiens_hsa007501.79580048
22beta-Alanine metabolism_Homo sapiens_hsa004101.78733881
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78352868
24Huntingtons disease_Homo sapiens_hsa050161.63802529
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57608025
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.57093867
27Circadian rhythm_Homo sapiens_hsa047101.55746862
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50498392
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39830124
30Folate biosynthesis_Homo sapiens_hsa007901.37276213
31Taste transduction_Homo sapiens_hsa047421.34676800
32Steroid biosynthesis_Homo sapiens_hsa001001.30729817
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28615024
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24352631
35Olfactory transduction_Homo sapiens_hsa047401.23445182
36Carbon metabolism_Homo sapiens_hsa012001.23078238
37PPAR signaling pathway_Homo sapiens_hsa033201.22520360
38Arginine biosynthesis_Homo sapiens_hsa002201.20138432
39Starch and sucrose metabolism_Homo sapiens_hsa005001.19382690
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11490814
41ABC transporters_Homo sapiens_hsa020101.10088937
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09743927
43Regulation of autophagy_Homo sapiens_hsa041401.08306202
44Histidine metabolism_Homo sapiens_hsa003400.96628036
45Non-homologous end-joining_Homo sapiens_hsa034500.96022385
46Renin-angiotensin system_Homo sapiens_hsa046140.94320378
47Fatty acid biosynthesis_Homo sapiens_hsa000610.93697308
48Insulin secretion_Homo sapiens_hsa049110.92822144
49Retinol metabolism_Homo sapiens_hsa008300.91817440
50Arginine and proline metabolism_Homo sapiens_hsa003300.88992555
51Caffeine metabolism_Homo sapiens_hsa002320.88967480
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88888848
53Sulfur metabolism_Homo sapiens_hsa009200.86207223
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85346099
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85277453
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83887277
57Fat digestion and absorption_Homo sapiens_hsa049750.80847301
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79387339
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79272153
60Tyrosine metabolism_Homo sapiens_hsa003500.77025582
61Complement and coagulation cascades_Homo sapiens_hsa046100.76330360
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76259019
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75737560
64Synaptic vesicle cycle_Homo sapiens_hsa047210.73994871
65Insulin signaling pathway_Homo sapiens_hsa049100.72656878
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72137123
67Amphetamine addiction_Homo sapiens_hsa050310.71377096
68Morphine addiction_Homo sapiens_hsa050320.71340049
69Nicotine addiction_Homo sapiens_hsa050330.69939564
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69129663
71* Metabolic pathways_Homo sapiens_hsa011000.67942605
72Phenylalanine metabolism_Homo sapiens_hsa003600.67104355
73Bile secretion_Homo sapiens_hsa049760.66679851
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65042594
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64631387
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63982379
77Ovarian steroidogenesis_Homo sapiens_hsa049130.63459110
78Dopaminergic synapse_Homo sapiens_hsa047280.62983980
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62880358
80Galactose metabolism_Homo sapiens_hsa000520.62849131
81Fructose and mannose metabolism_Homo sapiens_hsa000510.62038150
82GABAergic synapse_Homo sapiens_hsa047270.61566901
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61287101
84Lysine degradation_Homo sapiens_hsa003100.58461884
85Chemical carcinogenesis_Homo sapiens_hsa052040.58143137
86Circadian entrainment_Homo sapiens_hsa047130.55163498
87Glucagon signaling pathway_Homo sapiens_hsa049220.55058152
88Glycerolipid metabolism_Homo sapiens_hsa005610.54766063
89One carbon pool by folate_Homo sapiens_hsa006700.54255554
90Sulfur relay system_Homo sapiens_hsa041220.52192501
91Dilated cardiomyopathy_Homo sapiens_hsa054140.51863085
92Thyroid hormone synthesis_Homo sapiens_hsa049180.50077594
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49068883
94Calcium signaling pathway_Homo sapiens_hsa040200.48755098
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.48659343
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48395535
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46319929
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45790005
99Base excision repair_Homo sapiens_hsa034100.44857069
100AMPK signaling pathway_Homo sapiens_hsa041520.44119316
101Linoleic acid metabolism_Homo sapiens_hsa005910.43902971
102Vitamin digestion and absorption_Homo sapiens_hsa049770.43745094
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42779825
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42526020
105RNA degradation_Homo sapiens_hsa030180.42224902
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42069621
107Long-term potentiation_Homo sapiens_hsa047200.42031298
108Insulin resistance_Homo sapiens_hsa049310.41768317
109Purine metabolism_Homo sapiens_hsa002300.41280382
110Nitrogen metabolism_Homo sapiens_hsa009100.41162645
111cAMP signaling pathway_Homo sapiens_hsa040240.40265819
112Pentose phosphate pathway_Homo sapiens_hsa000300.39928883
113Salivary secretion_Homo sapiens_hsa049700.39919874
114Serotonergic synapse_Homo sapiens_hsa047260.38988429
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38973078
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38792128
117Biosynthesis of amino acids_Homo sapiens_hsa012300.38310632
118Cocaine addiction_Homo sapiens_hsa050300.36615377
119Glutamatergic synapse_Homo sapiens_hsa047240.34798943
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31485738
121Type II diabetes mellitus_Homo sapiens_hsa049300.31079620
122Renin secretion_Homo sapiens_hsa049240.30624462
123Prolactin signaling pathway_Homo sapiens_hsa049170.30010771
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.29088353
125Protein export_Homo sapiens_hsa030600.28403870
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.26164768

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