AUP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24028329
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24028329
3L-phenylalanine metabolic process (GO:0006558)4.23513674
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.23513674
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.10810317
6L-phenylalanine catabolic process (GO:0006559)4.10810317
7antigen processing and presentation of endogenous antigen (GO:0019883)3.85680039
8aromatic amino acid family catabolic process (GO:0009074)3.83976482
9lysine metabolic process (GO:0006553)3.80494120
10lysine catabolic process (GO:0006554)3.80494120
11pinocytosis (GO:0006907)3.78125056
12Golgi transport vesicle coating (GO:0048200)3.76870901
13COPI coating of Golgi vesicle (GO:0048205)3.76870901
14cysteine metabolic process (GO:0006534)3.74943070
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.68136620
16glyoxylate metabolic process (GO:0046487)3.65367948
17tryptophan catabolic process (GO:0006569)3.64132609
18indole-containing compound catabolic process (GO:0042436)3.64132609
19indolalkylamine catabolic process (GO:0046218)3.64132609
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62488121
21kynurenine metabolic process (GO:0070189)3.56246172
22alpha-linolenic acid metabolic process (GO:0036109)3.51863092
23negative regulation of erythrocyte differentiation (GO:0045647)3.47950905
24tryptophan metabolic process (GO:0006568)3.45955075
25sulfur amino acid catabolic process (GO:0000098)3.41107836
26urea cycle (GO:0000050)3.39589476
27urea metabolic process (GO:0019627)3.39589476
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.35977243
29valine metabolic process (GO:0006573)3.34545571
30proline biosynthetic process (GO:0006561)3.33395291
31serine family amino acid biosynthetic process (GO:0009070)3.31794000
32GDP-mannose metabolic process (GO:0019673)3.22136862
33glycine metabolic process (GO:0006544)3.22040704
34protein maturation by protein folding (GO:0022417)3.21273752
35bile acid biosynthetic process (GO:0006699)3.19608864
36negative regulation of fibrinolysis (GO:0051918)3.19013182
37peptidyl-glutamic acid carboxylation (GO:0017187)3.17338691
38protein carboxylation (GO:0018214)3.17338691
39homocysteine metabolic process (GO:0050667)3.15450084
40NIK/NF-kappaB signaling (GO:0038061)3.14985319
41nitrogen cycle metabolic process (GO:0071941)3.12504966
42complement activation, alternative pathway (GO:0006957)3.11707776
43regulation of superoxide anion generation (GO:0032928)3.10118323
44amino-acid betaine metabolic process (GO:0006577)3.05751971
45serine family amino acid metabolic process (GO:0009069)3.05478552
46serine family amino acid catabolic process (GO:0009071)3.01729268
47regulation of triglyceride catabolic process (GO:0010896)3.01383048
48high-density lipoprotein particle remodeling (GO:0034375)3.01372588
49response to peptidoglycan (GO:0032494)3.00758792
50mannose metabolic process (GO:0006013)2.94303057
51negative regulation of cholesterol transport (GO:0032375)2.91842745
52negative regulation of sterol transport (GO:0032372)2.91842745
53regulation of protein activation cascade (GO:2000257)2.90560771
54aromatic amino acid family metabolic process (GO:0009072)2.89010811
55positive regulation of gamma-delta T cell activation (GO:0046645)2.88062759
56pentose-phosphate shunt (GO:0006098)2.87500835
57plasma lipoprotein particle clearance (GO:0034381)2.86476257
58aldehyde catabolic process (GO:0046185)2.83834385
59ribosomal small subunit biogenesis (GO:0042274)2.82293836
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.80959852
61positive regulation of lipoprotein lipase activity (GO:0051006)2.80686435
62positive regulation of triglyceride lipase activity (GO:0061365)2.80686435
63disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.80449465
64killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.80449465
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77091920
66cellular modified amino acid catabolic process (GO:0042219)2.76466421
67regulation of complement activation (GO:0030449)2.76195935
68phospholipid efflux (GO:0033700)2.76021951
69regulation of fibrinolysis (GO:0051917)2.71994342
70modulation by virus of host process (GO:0019054)2.70340689
71L-serine metabolic process (GO:0006563)2.70129388
72protein retention in ER lumen (GO:0006621)2.69608528
73plasma lipoprotein particle remodeling (GO:0034369)2.69300172
74protein-lipid complex remodeling (GO:0034368)2.69300172
75macromolecular complex remodeling (GO:0034367)2.69300172
762-oxoglutarate metabolic process (GO:0006103)2.68690797
77regulation of cholesterol esterification (GO:0010872)2.67867293
78urate metabolic process (GO:0046415)2.67682894
79regulation of cholesterol homeostasis (GO:2000188)2.67477973
80plasma lipoprotein particle assembly (GO:0034377)2.67149664
81amyloid precursor protein catabolic process (GO:0042987)2.66105404
82alpha-amino acid catabolic process (GO:1901606)2.65723746
83glycosphingolipid catabolic process (GO:0046479)2.64774749
84reverse cholesterol transport (GO:0043691)2.63444436
85ethanol oxidation (GO:0006069)2.63179219
86NADH metabolic process (GO:0006734)2.62957605
87modulation by symbiont of host cellular process (GO:0044068)2.62766685
88UV protection (GO:0009650)2.62232217
89NADPH regeneration (GO:0006740)2.62010972
90regulation of interferon-beta biosynthetic process (GO:0045357)2.60531975
91glucose catabolic process (GO:0006007)2.59031328
92bile acid metabolic process (GO:0008206)2.58567771
93negative regulation of myeloid cell apoptotic process (GO:0033033)2.57546059
94complement activation, classical pathway (GO:0006958)2.57123982
95heme metabolic process (GO:0042168)2.57119600
96protein-lipid complex assembly (GO:0065005)2.54661787
97complement activation (GO:0006956)2.53788583
98positive regulation of triglyceride metabolic process (GO:0090208)2.53409245
99regulation of gamma-delta T cell differentiation (GO:0045586)2.53078431
100regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52313190
101immunoglobulin mediated immune response (GO:0016064)2.51687426
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.50861228
103heme biosynthetic process (GO:0006783)2.50515715
104tyrosine metabolic process (GO:0006570)2.50221117
105protoporphyrinogen IX metabolic process (GO:0046501)2.49794092
106glycolipid catabolic process (GO:0019377)2.49750642
107benzene-containing compound metabolic process (GO:0042537)2.49089849
108disruption of cells of other organism (GO:0044364)2.47365199
109killing of cells of other organism (GO:0031640)2.47365199
110proline metabolic process (GO:0006560)2.47017712
111cellular amino acid catabolic process (GO:0009063)2.47016605
112cofactor catabolic process (GO:0051187)2.46143108
113aspartate family amino acid catabolic process (GO:0009068)2.45184785
114carnitine metabolic process (GO:0009437)2.44961103
115positive regulation by symbiont of host defense response (GO:0052509)2.44761936
116modulation by symbiont of host defense response (GO:0052031)2.44761936
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44761936
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44761936
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.44761936
120modulation by symbiont of host immune response (GO:0052553)2.44761936
121drug transport (GO:0015893)2.44599096
122drug transmembrane transport (GO:0006855)2.44267490
123nicotinamide nucleotide biosynthetic process (GO:0019359)2.43105218
124pyridine nucleotide biosynthetic process (GO:0019363)2.43105218
125lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42348187
126positive regulation of B cell differentiation (GO:0045579)2.41297190
127indolalkylamine metabolic process (GO:0006586)2.41278279
128triglyceride homeostasis (GO:0070328)2.40434998
129acylglycerol homeostasis (GO:0055090)2.40434998
130positive regulation of Cdc42 GTPase activity (GO:0043089)2.40278466
131response to thyroid hormone (GO:0097066)2.39553834
132positive regulation of interferon-alpha production (GO:0032727)2.39264264
133intestinal cholesterol absorption (GO:0030299)2.38407813
134fatty acid beta-oxidation (GO:0006635)2.37705370
135cellular biogenic amine catabolic process (GO:0042402)2.37574505
136amine catabolic process (GO:0009310)2.37574505
137response to muramyl dipeptide (GO:0032495)2.35977276
138retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.35532945
139pentose metabolic process (GO:0019321)2.35379911
140oxaloacetate metabolic process (GO:0006107)2.34974726
141regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.31434994
142neutrophil activation involved in immune response (GO:0002283)2.30484894
143deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.29486496
144viral transcription (GO:0019083)2.28664075
145regulation of type I interferon-mediated signaling pathway (GO:0060338)2.28536259
146mature B cell differentiation involved in immune response (GO:0002313)2.27432376
147peptidyl-arginine omega-N-methylation (GO:0035247)2.27191295
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.25331590
149formation of translation preinitiation complex (GO:0001731)2.24555843
150detection of bacterium (GO:0016045)2.23118413
151cellular response to interleukin-4 (GO:0071353)2.22107518
152positive regulation of nuclease activity (GO:0032075)2.21090580
153negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.16837439
154negative regulation of cell killing (GO:0031342)2.16837439
155glucose 6-phosphate metabolic process (GO:0051156)2.16510102
156spliceosomal tri-snRNP complex assembly (GO:0000244)2.16115339
157nucleobase-containing small molecule interconversion (GO:0015949)2.13839698
158regulation of necrotic cell death (GO:0010939)2.13439595
159positive regulation of extracellular matrix organization (GO:1903055)2.11932877
160negative regulation of cell size (GO:0045792)2.11577165
161positive thymic T cell selection (GO:0045059)2.11425782
162endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.10686744
163detection of other organism (GO:0098543)2.09655588
164chaperone mediated protein folding requiring cofactor (GO:0051085)2.08921592
165myeloid dendritic cell differentiation (GO:0043011)2.08776444
166regulation of monocyte differentiation (GO:0045655)2.08616750
167pyrimidine nucleoside salvage (GO:0043097)2.07414680
168pyrimidine-containing compound salvage (GO:0008655)2.07414680
169regulation of mast cell degranulation (GO:0043304)2.06025550
170nucleotide salvage (GO:0043173)2.05913896
171protein localization to endosome (GO:0036010)2.05888530
172cellular hyperosmotic response (GO:0071474)2.05342252
173response to interleukin-4 (GO:0070670)2.04900539
174myeloid dendritic cell activation (GO:0001773)2.04726857
175regulation of translational fidelity (GO:0006450)2.04592689
176poly(A)+ mRNA export from nucleus (GO:0016973)2.04315572
177negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.02218802
178regulation of nuclease activity (GO:0032069)2.01770711
179positive regulation of antigen processing and presentation (GO:0002579)2.01266226
180type I interferon signaling pathway (GO:0060337)2.01243665
181cellular response to type I interferon (GO:0071357)2.01243665
182amino sugar catabolic process (GO:0046348)2.00677108
183endoplasmic reticulum unfolded protein response (GO:0030968)2.00397385
184tricarboxylic acid metabolic process (GO:0072350)1.99636415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.03639352
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.48114018
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.38269353
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.27869864
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.13573491
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81781539
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.63115978
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.54298954
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.42708542
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26008459
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19529794
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16369880
13MYC_22102868_ChIP-Seq_BL_Human2.15026255
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.13697267
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11621060
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04894585
17VDR_21846776_ChIP-Seq_THP-1_Human2.03549394
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96492154
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92778381
20E2F7_22180533_ChIP-Seq_HELA_Human1.91112385
21ZNF263_19887448_ChIP-Seq_K562_Human1.88783229
22* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86525064
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86022587
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.84457570
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84135124
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78488304
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75802639
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70093394
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67401680
30MAF_26560356_Chip-Seq_TH1_Human1.64931661
31* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63706015
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63253773
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62901940
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61728700
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59511377
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.57667856
37* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57320286
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54083722
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52966144
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50665884
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48297377
42GATA1_22025678_ChIP-Seq_K562_Human1.46953510
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46008393
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.45717312
45SCL_19346495_ChIP-Seq_HPC-7_Human1.43408078
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41601201
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41434391
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41342367
49SPI1_23547873_ChIP-Seq_NB4_Human1.41045580
50UTX_26944678_Chip-Seq_JUKART_Human1.40360080
51* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39431619
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39376989
53GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38424112
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37448368
55* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36521878
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34954733
57VDR_24763502_ChIP-Seq_THP-1_Human1.34854503
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.34141857
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33850984
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.33190682
61* RUNX1_22412390_ChIP-Seq_EML_Mouse1.32893981
62LXR_22292898_ChIP-Seq_THP-1_Human1.32488277
63MYB_26560356_Chip-Seq_TH1_Human1.31845052
64* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31518740
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31246962
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30783740
67MYB_26560356_Chip-Seq_TH2_Human1.30574554
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28173854
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26162844
70P68_20966046_ChIP-Seq_HELA_Human1.25303607
71* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24387937
72KDM2B_26808549_Chip-Seq_DND41_Human1.23493357
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23064602
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22925477
75* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22194609
76* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21977828
77MAF_26560356_Chip-Seq_TH2_Human1.21872530
78CIITA_25753668_ChIP-Seq_RAJI_Human1.21754108
79GABP_19822575_ChIP-Seq_HepG2_Human1.21695508
80* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20103150
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19870622
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19698505
83NCOR1_26117541_ChIP-Seq_K562_Human1.18247271
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17079414
85BCOR_27268052_Chip-Seq_Bcells_Human1.16661916
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16449277
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15702530
88TCF7_22412390_ChIP-Seq_EML_Mouse1.15280807
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15098602
90* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14333630
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13799607
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.13786950
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.13636864
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13035437
95TFEB_21752829_ChIP-Seq_HELA_Human1.12864144
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12155564
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.12000213
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11798077
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11333158
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10629353
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10093564
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09651941
103XRN2_22483619_ChIP-Seq_HELA_Human1.09288094
104CLOCK_20551151_ChIP-Seq_293T_Human1.08869446
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08073028
106* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07286348
107ATF3_27146783_Chip-Seq_COLON_Human1.06419880
108* ETS1_20019798_ChIP-Seq_JURKAT_Human1.05544058
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05069232
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.04952637
111* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04805769
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.04450425
113* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02298841
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02267404
115GABP_17652178_ChIP-ChIP_JURKAT_Human1.01834580
116DCP1A_22483619_ChIP-Seq_HELA_Human1.01791363
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99522083
118BCL6_27268052_Chip-Seq_Bcells_Human0.98775738
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98458437
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97879762
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97857548
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97134718
123TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97006621
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96867844
125FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95360411
126EST1_17652178_ChIP-ChIP_JURKAT_Human0.94974773
127* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93928754
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93548202
129FOXP3_21729870_ChIP-Seq_TREG_Human0.93518144
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93024473
131KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92869824
132RACK7_27058665_Chip-Seq_MCF-7_Human0.91461448
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.89983201
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89831621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.44215511
2MP0002139_abnormal_hepatobiliary_system4.44085810
3MP0005365_abnormal_bile_salt3.37112353
4MP0005085_abnormal_gallbladder_physiolo3.05959045
5MP0009840_abnormal_foam_cell2.95381766
6MP0008260_abnormal_autophagy2.87124259
7MP0008875_abnormal_xenobiotic_pharmacok2.48392131
8MP0003191_abnormal_cellular_cholesterol2.48012135
9MP0003806_abnormal_nucleotide_metabolis2.42140620
10MP0003436_decreased_susceptibility_to2.37781470
11MP0005083_abnormal_biliary_tract2.36080251
12MP0001835_abnormal_antigen_presentation2.34710780
13MP0000685_abnormal_immune_system2.26621615
14MP0003656_abnormal_erythrocyte_physiolo2.23002076
15MP0010329_abnormal_lipoprotein_level2.03683267
16MP0003252_abnormal_bile_duct1.97251058
17MP0009785_altered_susceptibility_to1.96412343
18MP0001666_abnormal_nutrient_absorption1.86031549
19MP0005332_abnormal_amino_acid1.84639152
20MP0002138_abnormal_hepatobiliary_system1.77293434
21MP0005058_abnormal_lysosome_morphology1.76935268
22MP0003303_peritoneal_inflammation1.76260834
23MP0005025_abnormal_response_to1.75524159
24MP0000609_abnormal_liver_physiology1.72877231
25MP0003724_increased_susceptibility_to1.71184399
26MP0001800_abnormal_humoral_immune1.71067037
27MP0002877_abnormal_melanocyte_morpholog1.67239078
28MP0001790_abnormal_immune_system1.66062178
29MP0005387_immune_system_phenotype1.66062178
30MP0005671_abnormal_response_to1.64507846
31MP0005464_abnormal_platelet_physiology1.64327490
32MP0002419_abnormal_innate_immunity1.62770869
33MP0006082_CNS_inflammation1.60979240
34MP0005000_abnormal_immune_tolerance1.59165305
35MP0008469_abnormal_protein_level1.55713716
36MP0005319_abnormal_enzyme/_coenzyme1.54642693
37MP0003186_abnormal_redox_activity1.53807605
38MP0002452_abnormal_antigen_presenting1.51851641
39MP0009643_abnormal_urine_homeostasis1.51615315
40MP0002723_abnormal_immune_serum1.48793411
41MP0003300_gastrointestinal_ulcer1.45684823
42MP0001845_abnormal_inflammatory_respons1.40607725
43MP0009333_abnormal_splenocyte_physiolog1.39453770
44MP0003763_abnormal_thymus_physiology1.38575683
45MP0002420_abnormal_adaptive_immunity1.38170149
46MP0001819_abnormal_immune_cell1.36994455
47MP0001853_heart_inflammation1.36586933
48MP0001873_stomach_inflammation1.34820396
49MP0002148_abnormal_hypersensitivity_rea1.34812921
50MP0009764_decreased_sensitivity_to1.31823166
51MP0010155_abnormal_intestine_physiology1.30522994
52MP0002166_altered_tumor_susceptibility1.30466823
53MP0005584_abnormal_enzyme/coenzyme_acti1.28445150
54MP0003453_abnormal_keratinocyte_physiol1.28259506
55MP0002396_abnormal_hematopoietic_system1.28057504
56MP0000689_abnormal_spleen_morphology1.27989971
57MP0002398_abnormal_bone_marrow1.27817098
58MP0002405_respiratory_system_inflammati1.27717667
59MP0003195_calcinosis1.27549763
60MP0003705_abnormal_hypodermis_morpholog1.27224984
61MP0004947_skin_inflammation1.27108679
62MP0004019_abnormal_vitamin_homeostasis1.26453032
63MP0005397_hematopoietic_system_phenotyp1.25567048
64MP0001545_abnormal_hematopoietic_system1.25567048
65MP0001533_abnormal_skeleton_physiology1.25142339
66MP0003075_altered_response_to1.25049903
67MP0001764_abnormal_homeostasis1.22484764
68MP0000678_abnormal_parathyroid_gland1.22389473
69MP0002118_abnormal_lipid_homeostasis1.20344118
70MP0002722_abnormal_immune_system1.19684466
71MP0000716_abnormal_immune_system1.19196866
72MP0000598_abnormal_liver_morphology1.19112178
73MP0000858_altered_metastatic_potential1.16449754
74MP0003111_abnormal_nucleus_morphology1.15684127
75MP0002429_abnormal_blood_cell1.12617579
76MP0004185_abnormal_adipocyte_glucose1.09353939
77MP0009763_increased_sensitivity_to1.08530756
78MP0005636_abnormal_mineral_homeostasis1.05471435
79MP0008007_abnormal_cellular_replicative1.05170459
80MP0003172_abnormal_lysosome_physiology1.04019729
81MP0004808_abnormal_hematopoietic_stem1.03140514
82MP0001849_ear_inflammation1.03027236
83MP0005501_abnormal_skin_physiology1.02746201
84MP0002136_abnormal_kidney_physiology1.02723040
85MP0005076_abnormal_cell_differentiation1.00782574
86MP0006054_spinal_hemorrhage1.00714079
87MP0000490_abnormal_crypts_of1.00677254
88MP0002796_impaired_skin_barrier0.95117471
89MP0002998_abnormal_bone_remodeling0.94613766
90MP0003566_abnormal_cell_adhesion0.92949469
91MP0005023_abnormal_wound_healing0.91929919
92MP0003183_abnormal_peptide_metabolism0.91759535
93MP0003786_premature_aging0.89603197
94MP0000604_amyloidosis0.88590085
95MP0005165_increased_susceptibility_to0.87294967
96MP0002933_joint_inflammation0.86865931
97MP0002006_tumorigenesis0.85510307
98MP0000313_abnormal_cell_death0.85506006
99MP0006036_abnormal_mitochondrial_physio0.84494478
100MP0002132_abnormal_respiratory_system0.83694648
101MP0005220_abnormal_exocrine_pancreas0.82622840
102MP0004264_abnormal_extraembryonic_tissu0.82092443
103MP0004381_abnormal_hair_follicle0.81705096
104MP0005451_abnormal_body_composition0.81083396
105MP0001756_abnormal_urination0.80662210
106MP0009931_abnormal_skin_appearance0.80531688
107MP0000343_altered_response_to0.80420322
108MP0000465_gastrointestinal_hemorrhage0.79672539
109MP0009642_abnormal_blood_homeostasis0.79076802
110MP0001216_abnormal_epidermal_layer0.78236894
111MP0004957_abnormal_blastocyst_morpholog0.77774719
112MP0001663_abnormal_digestive_system0.77557818
113MP0002060_abnormal_skin_morphology0.77411509
114MP0003866_abnormal_defecation0.76732508
115MP0001661_extended_life_span0.76009032
116MP0000703_abnormal_thymus_morphology0.75661397
117MP0004147_increased_porphyrin_level0.72235366
118MP0005166_decreased_susceptibility_to0.71212669
119MP0003448_altered_tumor_morphology0.70917256
120MP0003011_delayed_dark_adaptation0.70433959
121MP0003693_abnormal_embryo_hatching0.70245210
122MP0002019_abnormal_tumor_incidence0.69383801
123MP0009278_abnormal_bone_marrow0.68571204
124MP0008438_abnormal_cutaneous_collagen0.67925032
125MP0005670_abnormal_white_adipose0.67868922
126MP0009765_abnormal_xenobiotic_induced0.67817040

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.15793250
2Deep venous thrombosis (HP:0002625)3.85235377
3Xanthomatosis (HP:0000991)3.79897797
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.76822207
5Abnormality of liposaccharide metabolism (HP:0010968)3.43868942
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.43868942
7Abnormality of glycolipid metabolism (HP:0010969)3.43868942
8Intrahepatic cholestasis (HP:0001406)3.39912878
9Systemic lupus erythematosus (HP:0002725)3.34761604
10Complement deficiency (HP:0004431)3.23172491
11Increased cerebral lipofuscin (HP:0011813)3.19517808
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09555118
13Prolonged partial thromboplastin time (HP:0003645)3.06613799
14Recurrent gram-negative bacterial infections (HP:0005420)3.05939907
15Eczematoid dermatitis (HP:0000976)3.03671830
16Hyperammonemia (HP:0001987)3.01671895
17Joint hemorrhage (HP:0005261)3.01523585
18Hypobetalipoproteinemia (HP:0003563)3.00747167
19Hyperlipoproteinemia (HP:0010980)2.97579856
20Abnormal gallbladder physiology (HP:0012438)2.96672974
21Cholecystitis (HP:0001082)2.96672974
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.96132139
23Vertebral compression fractures (HP:0002953)2.95324497
24Abnormality of complement system (HP:0005339)2.93153928
25Ragged-red muscle fibers (HP:0003200)2.92855519
26Elevated erythrocyte sedimentation rate (HP:0003565)2.89573209
27Vacuolated lymphocytes (HP:0001922)2.88843960
28Recurrent bacterial skin infections (HP:0005406)2.87733486
29Abnormality of pyrimidine metabolism (HP:0004353)2.83746151
30Recurrent abscess formation (HP:0002722)2.81304543
31Abnormality of fatty-acid metabolism (HP:0004359)2.77162005
32Ketosis (HP:0001946)2.70895764
33Obstructive lung disease (HP:0006536)2.70405163
34Chronic obstructive pulmonary disease (HP:0006510)2.70405163
35Autoimmune thrombocytopenia (HP:0001973)2.67626906
36Hypertensive crisis (HP:0100735)2.66610707
37Abnormality of the common coagulation pathway (HP:0010990)2.66593691
38Abnormality of sulfur amino acid metabolism (HP:0004339)2.66560946
39Hyperbilirubinemia (HP:0002904)2.66293634
40Myocardial infarction (HP:0001658)2.63818397
41Loss of speech (HP:0002371)2.63803209
42Hepatosplenomegaly (HP:0001433)2.57579448
43Petechiae (HP:0000967)2.56198225
44Hyperglycinuria (HP:0003108)2.53150359
45Thrombocytosis (HP:0001894)2.52492381
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.52128339
47Fat malabsorption (HP:0002630)2.51299834
48Pustule (HP:0200039)2.50003436
49Increased serum ferritin (HP:0003281)2.48961627
50Abnormality of nucleobase metabolism (HP:0010932)2.47606564
51Colitis (HP:0002583)2.44168511
52Microvesicular hepatic steatosis (HP:0001414)2.40619579
53Abnormal platelet function (HP:0011869)2.38856834
54Impaired platelet aggregation (HP:0003540)2.38856834
55Abnormality of iron homeostasis (HP:0011031)2.37448944
56Chronic otitis media (HP:0000389)2.36390028
57J-shaped sella turcica (HP:0002680)2.34436819
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33891564
59Abnormality of serine family amino acid metabolism (HP:0010894)2.33753189
60Abnormality of glycine metabolism (HP:0010895)2.33753189
61Mediastinal lymphadenopathy (HP:0100721)2.33464759
62Gingival bleeding (HP:0000225)2.32289271
63Cellulitis (HP:0100658)2.31325844
64Epistaxis (HP:0000421)2.30236938
65Abnormality of purine metabolism (HP:0004352)2.29536771
66Hypolipoproteinemia (HP:0010981)2.29523703
67Hypercholesterolemia (HP:0003124)2.29056381
68Nasal polyposis (HP:0100582)2.28657859
69Glomerulonephritis (HP:0000099)2.26570976
70Abnormality of transition element cation homeostasis (HP:0011030)2.24975263
71Myositis (HP:0100614)2.24190230
72Abnormality of the intrinsic pathway (HP:0010989)2.23230409
73Abnormality of the nasal mucosa (HP:0000433)2.22722646
74Generalized aminoaciduria (HP:0002909)2.21591901
75Steatorrhea (HP:0002570)2.20810653
76Gastrointestinal inflammation (HP:0004386)2.20680397
77Agammaglobulinemia (HP:0004432)2.19044147
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17684677
79Polycythemia (HP:0001901)2.17539061
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17382320
81Dicarboxylic aciduria (HP:0003215)2.17382320
82Gout (HP:0001997)2.17378828
83Recurrent viral infections (HP:0004429)2.17206351
84Hemorrhage of the eye (HP:0011885)2.16438222
85Fatigue (HP:0012378)2.15279390
86Hyperglycinemia (HP:0002154)2.14999814
87Progressive muscle weakness (HP:0003323)2.14126498
88Recurrent skin infections (HP:0001581)2.13985278
89Seborrheic dermatitis (HP:0001051)2.13886393
90Hypoglycemic coma (HP:0001325)2.13552716
91Abnormality of methionine metabolism (HP:0010901)2.13299263
92Urticaria (HP:0001025)2.12010139
93Poikilocytosis (HP:0004447)2.11552579
94Reticulocytosis (HP:0001923)2.10346719
95Achilles tendon contracture (HP:0001771)2.09916341
96Abnormality of macrophages (HP:0004311)2.09488457
97Dysostosis multiplex (HP:0000943)2.07325258
98Hypoalphalipoproteinemia (HP:0003233)2.06361370
99Rough bone trabeculation (HP:0100670)2.06238777
100IgM deficiency (HP:0002850)2.05744551
101Nausea (HP:0002018)2.05587287
102Abnormality of the heme biosynthetic pathway (HP:0010472)2.05471798
103Prolonged neonatal jaundice (HP:0006579)2.05452823
104Recurrent fungal infections (HP:0002841)2.05217867
105Abnormality of polysaccharide metabolism (HP:0011012)2.04765741
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04765741
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04765741
108Purpura (HP:0000979)2.04141228
109Thrombophlebitis (HP:0004418)2.03998936
110Abnormality of the Achilles tendon (HP:0005109)2.03188275
111Nonimmune hydrops fetalis (HP:0001790)2.01318868
112Hepatocellular carcinoma (HP:0001402)2.00755592
113Spastic diplegia (HP:0001264)1.97017929
114Centrally nucleated skeletal muscle fibers (HP:0003687)1.95255767
115Abnormality of reticulocytes (HP:0004312)1.94997623
116Distal lower limb muscle weakness (HP:0009053)1.94837716
117Meningitis (HP:0001287)1.94485853
118Pancreatitis (HP:0001733)1.94246089
119Interstitial pulmonary disease (HP:0006530)1.93807988
120Spontaneous hematomas (HP:0007420)1.93764627
121Inflammation of the large intestine (HP:0002037)1.91721649
122Increased IgE level (HP:0003212)1.91344367
123Esophageal varix (HP:0002040)1.91109243
124Urinary glycosaminoglycan excretion (HP:0003541)1.90189843
125Mucopolysacchariduria (HP:0008155)1.90189843
126Metabolic acidosis (HP:0001942)1.90093660
127Trismus (HP:0000211)1.89609578
128Menorrhagia (HP:0000132)1.88351379
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87848275
130Abnormality of proline metabolism (HP:0010907)1.87135025
131Hydroxyprolinuria (HP:0003080)1.87135025
132Vascular calcification (HP:0004934)1.86318730
133Acanthocytosis (HP:0001927)1.85176342
134Hypertriglyceridemia (HP:0002155)1.84425619
135Gastrointestinal stroma tumor (HP:0100723)1.83918526
136Polygenic inheritance (HP:0010982)1.82360148
137Delayed CNS myelination (HP:0002188)1.82292774
138Malnutrition (HP:0004395)1.81812606
139Periodontitis (HP:0000704)1.81276229
140Axonal loss (HP:0003447)1.80749418
141Late onset (HP:0003584)1.80682026
142Abnormal enzyme/coenzyme activity (HP:0012379)1.77558126
143Elevated alkaline phosphatase (HP:0003155)1.77238676
144Abnormality of the thoracic spine (HP:0100711)1.75094470
145Amyloidosis (HP:0011034)1.74175789
146Thoracic kyphosis (HP:0002942)1.73682784
147Villous atrophy (HP:0011473)1.73385410
148Abnormality of small intestinal villus morphology (HP:0011472)1.73385410
149Abnormal trabecular bone morphology (HP:0100671)1.71867831
150Distal upper limb amyotrophy (HP:0007149)1.71655858
151Upper limb amyotrophy (HP:0009129)1.71655858
152Abnormality of alkaline phosphatase activity (HP:0004379)1.70847919
153Cholelithiasis (HP:0001081)1.70473717
154Abnormality of glycolysis (HP:0004366)1.68242837
155Distal lower limb amyotrophy (HP:0008944)1.68063895
156Prolonged bleeding time (HP:0003010)1.67558353
157Progressive neurologic deterioration (HP:0002344)1.67528087
158Gastrointestinal infarctions (HP:0005244)1.66885617
159Granulocytopenia (HP:0001913)1.64841005
160Rhabdomyolysis (HP:0003201)1.63007570
161Abnormality of T cell physiology (HP:0011840)1.61605757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.24058838
2MAP4K13.42001875
3BCKDK3.25436185
4TRIB32.90389295
5TBK12.71943578
6SMG12.69297772
7NME22.69113362
8PRPF4B2.56186190
9TYK22.44071455
10PKN22.29484051
11PIM22.17767893
12BLK2.17402538
13FGFR42.07039377
14ZAP702.01594173
15EIF2AK11.89892212
16IKBKE1.87429286
17MAP3K141.75236710
18RIPK41.74667252
19FLT31.69714099
20MAP3K101.68123276
21MAP2K31.68101435
22TAOK31.67462333
23IRAK41.67108559
24ICK1.62246457
25KIT1.61603758
26VRK21.59968085
27IRAK31.57688465
28JAK31.57488069
29GRK61.57150449
30TXK1.54010866
31STK101.52931221
32MAP3K111.50174167
33TGFBR21.50105038
34KDR1.50058399
35BUB11.49580673
36BTK1.46235981
37EEF2K1.41578722
38LRRK21.39173026
39SIK11.36747123
40NEK91.34910598
41TESK21.33445029
42EPHA21.29607791
43PDK21.27927209
44RPS6KA41.25151662
45IKBKB1.24353326
46CSF1R1.21598283
47JAK11.14861841
48ARAF1.11995742
49SIK31.10037168
50CSK1.09069146
51PIM11.08336153
52MAP3K31.03246003
53TLK10.99769912
54SYK0.99743533
55PTK60.98713284
56MAPK110.97973701
57EPHA30.96301397
58ITK0.93674248
59TEC0.92296968
60JAK20.88996245
61PAK40.85030654
62MAP3K10.84545244
63EPHB10.83445930
64TESK10.83356562
65PIK3CG0.83030043
66SCYL20.81372201
67PDPK10.76384309
68CHUK0.76050986
69LCK0.75433000
70CDK120.74054855
71LYN0.73748801
72CDK40.73570010
73NEK20.71079928
74MAP3K80.70027857
75NME10.67433398
76DAPK10.66916425
77MAPKAPK30.65586834
78DYRK1B0.65556620
79HCK0.65545300
80TAOK20.65104636
81MATK0.63407861
82FGFR30.63308047
83TAOK10.63298228
84STK40.62091740
85MST1R0.60035137
86CDK70.59495122
87CDC42BPA0.58308071
88ABL20.58283128
89TTN0.57714216
90CDK80.57381294
91MAP2K20.56976049
92SIK20.56536690
93RPS6KA60.54528155
94BMX0.53983336
95ILK0.53127765
96PRKD20.51571936
97MAPK40.50462280
98MARK30.49703236
99CDK60.49617990
100STK160.49068114
101MAP3K70.48009452
102ACVR1B0.47903718
103MAP3K50.47569710
104IRAK20.47220735
105PDK10.46804384
106DAPK30.46049009
107RPS6KC10.44431973
108RPS6KL10.44431973
109RIPK10.42734120
110BRAF0.41678407
111TGFBR10.41059181
112FGR0.39126531
113MTOR0.39106006
114EIF2AK30.38582024
115ALK0.38308683
116MAPKAPK20.38201610
117MAP3K130.36370685
118TNK20.35143757
119AURKA0.34854777
120PAK10.34348978
121HIPK20.34099140
122NLK0.33049309
123IRAK10.32116841
124MAPK120.30976194
125PRKCD0.30332015
126DYRK30.28945086
127MAP2K60.28896415
128CLK10.27351138
129PRKG20.26938669
130FES0.26126759
131RPS6KB20.25321053

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.06905932
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80412238
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.53586522
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22220533
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15672500
6Staphylococcus aureus infection_Homo sapiens_hsa051502.11336959
7Fatty acid degradation_Homo sapiens_hsa000712.06700947
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02531321
9Complement and coagulation cascades_Homo sapiens_hsa046101.97629701
10Tryptophan metabolism_Homo sapiens_hsa003801.96543054
11Arginine biosynthesis_Homo sapiens_hsa002201.91417050
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87273804
13Caffeine metabolism_Homo sapiens_hsa002321.82179528
14Peroxisome_Homo sapiens_hsa041461.69510130
15Sulfur relay system_Homo sapiens_hsa041221.69381623
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.67553571
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.62850638
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62341290
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58451454
20Folate biosynthesis_Homo sapiens_hsa007901.57679388
21Selenocompound metabolism_Homo sapiens_hsa004501.55369334
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.53804742
23Nitrogen metabolism_Homo sapiens_hsa009101.48360386
24Pentose phosphate pathway_Homo sapiens_hsa000301.42579968
25One carbon pool by folate_Homo sapiens_hsa006701.38199452
26PPAR signaling pathway_Homo sapiens_hsa033201.37224945
27Propanoate metabolism_Homo sapiens_hsa006401.35700368
28beta-Alanine metabolism_Homo sapiens_hsa004101.33242493
29Biosynthesis of amino acids_Homo sapiens_hsa012301.32913889
30Carbon metabolism_Homo sapiens_hsa012001.28554783
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27534912
32Histidine metabolism_Homo sapiens_hsa003401.27147496
33Allograft rejection_Homo sapiens_hsa053301.25112661
34Other glycan degradation_Homo sapiens_hsa005111.24739016
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24107125
36N-Glycan biosynthesis_Homo sapiens_hsa005101.23989328
37Chemical carcinogenesis_Homo sapiens_hsa052041.21687331
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21395787
39Fatty acid metabolism_Homo sapiens_hsa012121.20456036
40Primary immunodeficiency_Homo sapiens_hsa053401.18924458
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16883646
42Fat digestion and absorption_Homo sapiens_hsa049751.15113883
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15111958
44Spliceosome_Homo sapiens_hsa030401.12470437
45Shigellosis_Homo sapiens_hsa051311.10697877
46Leishmaniasis_Homo sapiens_hsa051401.10481906
47Bladder cancer_Homo sapiens_hsa052191.09892022
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.08593093
49Starch and sucrose metabolism_Homo sapiens_hsa005001.06789370
50Antigen processing and presentation_Homo sapiens_hsa046121.06555176
51Autoimmune thyroid disease_Homo sapiens_hsa053201.05888416
52Pyruvate metabolism_Homo sapiens_hsa006201.05400811
53Chronic myeloid leukemia_Homo sapiens_hsa052201.04873209
54Ribosome_Homo sapiens_hsa030101.03722367
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03441758
56Asthma_Homo sapiens_hsa053101.02808359
57Graft-versus-host disease_Homo sapiens_hsa053321.02144833
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00260920
59Prion diseases_Homo sapiens_hsa050200.98964695
60Epstein-Barr virus infection_Homo sapiens_hsa051690.97731999
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.95946061
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95582464
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.95182301
64Non-small cell lung cancer_Homo sapiens_hsa052230.94058452
65TNF signaling pathway_Homo sapiens_hsa046680.93634663
66Butanoate metabolism_Homo sapiens_hsa006500.92671832
67Retinol metabolism_Homo sapiens_hsa008300.90917583
68Glutathione metabolism_Homo sapiens_hsa004800.90822362
69Legionellosis_Homo sapiens_hsa051340.90415370
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.90225504
71ABC transporters_Homo sapiens_hsa020100.90013455
72Vitamin digestion and absorption_Homo sapiens_hsa049770.89394151
73Measles_Homo sapiens_hsa051620.87642001
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.87147549
75Hepatitis B_Homo sapiens_hsa051610.86841838
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86704992
77Vibrio cholerae infection_Homo sapiens_hsa051100.86070976
78Hepatitis C_Homo sapiens_hsa051600.85770345
79Galactose metabolism_Homo sapiens_hsa000520.83456727
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82588435
81Pancreatic cancer_Homo sapiens_hsa052120.82561358
82Viral myocarditis_Homo sapiens_hsa054160.82497623
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81754705
84Arginine and proline metabolism_Homo sapiens_hsa003300.81474215
85Phenylalanine metabolism_Homo sapiens_hsa003600.81391581
86DNA replication_Homo sapiens_hsa030300.79868767
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79333503
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78984180
89Rheumatoid arthritis_Homo sapiens_hsa053230.76937348
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76004158
91Salmonella infection_Homo sapiens_hsa051320.75936503
92Lysosome_Homo sapiens_hsa041420.73680526
93Bile secretion_Homo sapiens_hsa049760.73247435
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71489673
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70905710
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70648279
97Fructose and mannose metabolism_Homo sapiens_hsa000510.70630613
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.70615439
99Lysine degradation_Homo sapiens_hsa003100.69066272
100Phagosome_Homo sapiens_hsa041450.67534584
101Osteoclast differentiation_Homo sapiens_hsa043800.66793636
102Viral carcinogenesis_Homo sapiens_hsa052030.66615296
103B cell receptor signaling pathway_Homo sapiens_hsa046620.65450453
104HTLV-I infection_Homo sapiens_hsa051660.65333816
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64551045
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63637417
107Glycerolipid metabolism_Homo sapiens_hsa005610.63444248
108Herpes simplex infection_Homo sapiens_hsa051680.63185394
109Apoptosis_Homo sapiens_hsa042100.62940015
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62919354
111Tyrosine metabolism_Homo sapiens_hsa003500.62798880
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62726785
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62714875
114Pertussis_Homo sapiens_hsa051330.61124118
115VEGF signaling pathway_Homo sapiens_hsa043700.59303795
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57271623
117Influenza A_Homo sapiens_hsa051640.57062031
118Notch signaling pathway_Homo sapiens_hsa043300.57047154
119Type I diabetes mellitus_Homo sapiens_hsa049400.56373104
120Base excision repair_Homo sapiens_hsa034100.56281406
121Sulfur metabolism_Homo sapiens_hsa009200.56098895
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54778623
123Mismatch repair_Homo sapiens_hsa034300.53503186
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53483623
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53164869
126Proteasome_Homo sapiens_hsa030500.52309168
127Hematopoietic cell lineage_Homo sapiens_hsa046400.49781247
128Acute myeloid leukemia_Homo sapiens_hsa052210.48871713
129Steroid biosynthesis_Homo sapiens_hsa001000.48788774
130Nucleotide excision repair_Homo sapiens_hsa034200.47689365
131Malaria_Homo sapiens_hsa051440.47235984
132Small cell lung cancer_Homo sapiens_hsa052220.46384979
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45192034
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44572631
135Fatty acid elongation_Homo sapiens_hsa000620.44566971
136Toxoplasmosis_Homo sapiens_hsa051450.44528340
137Pyrimidine metabolism_Homo sapiens_hsa002400.44523870
138HIF-1 signaling pathway_Homo sapiens_hsa040660.42729615
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.41554899
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.41351210
141Endocytosis_Homo sapiens_hsa041440.40457606
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39340158
143Tuberculosis_Homo sapiens_hsa051520.38708845

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