AURKA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.70395417
2protein localization to kinetochore (GO:0034501)5.45053761
3mitotic sister chromatid segregation (GO:0000070)5.03243387
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.00464961
5protein localization to chromosome, centromeric region (GO:0071459)4.95422145
6metaphase plate congression (GO:0051310)4.86956396
7sister chromatid segregation (GO:0000819)4.51716724
8mitotic nuclear envelope disassembly (GO:0007077)4.48011705
9attachment of spindle microtubules to kinetochore (GO:0008608)4.47729840
10establishment of chromosome localization (GO:0051303)4.41404302
11kinetochore organization (GO:0051383)4.35481307
12* regulation of spindle organization (GO:0090224)4.31962003
13CENP-A containing nucleosome assembly (GO:0034080)4.31629656
14regulation of mitotic spindle organization (GO:0060236)4.29333823
15mitotic chromosome condensation (GO:0007076)4.29137672
16DNA replication checkpoint (GO:0000076)4.23595405
17chromatin remodeling at centromere (GO:0031055)4.23016392
18DNA strand elongation involved in DNA replication (GO:0006271)4.22367827
19positive regulation of chromosome segregation (GO:0051984)4.21196397
20nucleobase biosynthetic process (GO:0046112)4.19593849
21DNA replication initiation (GO:0006270)4.17593889
22membrane disassembly (GO:0030397)4.15392452
23nuclear envelope disassembly (GO:0051081)4.15392452
24DNA replication-dependent nucleosome organization (GO:0034723)4.15159849
25DNA replication-dependent nucleosome assembly (GO:0006335)4.15159849
26purine nucleobase biosynthetic process (GO:0009113)4.12607345
27spindle checkpoint (GO:0031577)4.04697278
28kinetochore assembly (GO:0051382)4.04001515
29regulation of chromosome segregation (GO:0051983)4.01431959
30DNA strand elongation (GO:0022616)4.01396272
31DNA unwinding involved in DNA replication (GO:0006268)4.00931107
32DNA replication-independent nucleosome assembly (GO:0006336)3.98015236
33DNA replication-independent nucleosome organization (GO:0034724)3.98015236
34negative regulation of chromosome segregation (GO:0051985)3.90293813
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.89570760
36nuclear pore organization (GO:0006999)3.87720547
37negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.86086803
38negative regulation of sister chromatid segregation (GO:0033046)3.86086803
39negative regulation of mitotic sister chromatid separation (GO:2000816)3.86086803
40negative regulation of mitotic sister chromatid segregation (GO:0033048)3.86086803
41histone exchange (GO:0043486)3.84291517
42formation of translation preinitiation complex (GO:0001731)3.83144929
43telomere maintenance via semi-conservative replication (GO:0032201)3.83095850
44spindle assembly checkpoint (GO:0071173)3.80795250
45ribosome assembly (GO:0042255)3.79869373
46mitotic spindle checkpoint (GO:0071174)3.77764139
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.77335446
48mitotic spindle assembly checkpoint (GO:0007094)3.77097428
49mitotic sister chromatid cohesion (GO:0007064)3.75328982
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.72420065
51protein localization to chromosome (GO:0034502)3.71653209
52positive regulation of histone H3-K4 methylation (GO:0051571)3.71002269
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.65968260
54establishment of integrated proviral latency (GO:0075713)3.60846571
55maturation of SSU-rRNA (GO:0030490)3.60384619
56ribosome biogenesis (GO:0042254)3.57387334
57regulation of sister chromatid segregation (GO:0033045)3.53825718
58regulation of mitotic sister chromatid separation (GO:0010965)3.53825718
59regulation of mitotic sister chromatid segregation (GO:0033047)3.53825718
60nuclear pore complex assembly (GO:0051292)3.52733407
61telomere maintenance via recombination (GO:0000722)3.52020786
62chromosome segregation (GO:0007059)3.51678764
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.51192152
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51192152
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51192152
66mitotic recombination (GO:0006312)3.49549463
67pore complex assembly (GO:0046931)3.48555341
68* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46534828
69DNA topological change (GO:0006265)3.42881288
70DNA ligation (GO:0006266)3.42141081
71meiotic chromosome segregation (GO:0045132)3.38547675
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34304015
73nuclear envelope organization (GO:0006998)3.33680635
74microtubule depolymerization (GO:0007019)3.33046033
75ventricular cardiac muscle cell development (GO:0055015)3.29980324
76spliceosomal snRNP assembly (GO:0000387)3.28738384
77IMP biosynthetic process (GO:0006188)3.28401183
78regulation of DNA methylation (GO:0044030)3.28353792
79folic acid-containing compound biosynthetic process (GO:0009396)3.25993747
80telomere maintenance via telomere lengthening (GO:0010833)3.25031056
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23369885
82chromosome condensation (GO:0030261)3.22391005
83protein K6-linked ubiquitination (GO:0085020)3.20216209
84positive regulation of DNA-dependent DNA replication (GO:2000105)3.19284023
85ribonucleoprotein complex biogenesis (GO:0022613)3.18272033
86chromatin assembly or disassembly (GO:0006333)3.15395007
87spindle assembly involved in mitosis (GO:0090307)3.13411738
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.13139993
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12767395
90mitotic G2/M transition checkpoint (GO:0044818)3.10941633
91* regulation of centrosome cycle (GO:0046605)3.10781566
92ribosomal large subunit biogenesis (GO:0042273)3.08797420
93rRNA processing (GO:0006364)3.07945192
94negative regulation of mitosis (GO:0045839)3.06123087
95regulation of exit from mitosis (GO:0007096)3.05798808
96DNA deamination (GO:0045006)3.05384633
97regulation of centriole replication (GO:0046599)3.04772291
98* mitotic cell cycle (GO:0000278)3.03488121
99folic acid metabolic process (GO:0046655)3.02758078
100nucleotide-excision repair, DNA gap filling (GO:0006297)3.02745483
101proteasome assembly (GO:0043248)3.01993458
102ATP-dependent chromatin remodeling (GO:0043044)3.01059311
103rRNA modification (GO:0000154)3.00959795
104rRNA metabolic process (GO:0016072)2.99188438
105meiotic cell cycle (GO:0051321)2.98811504
106regulation of sister chromatid cohesion (GO:0007063)2.96766252
107regulation of DNA endoreduplication (GO:0032875)2.96539584
108mitotic cytokinesis (GO:0000281)2.95008358
109cell cycle G1/S phase transition (GO:0044843)2.94850097
110G1/S transition of mitotic cell cycle (GO:0000082)2.94850097
111DNA conformation change (GO:0071103)2.94718385
112positive regulation of cytokinesis (GO:0032467)2.93538133
113maturation of 5.8S rRNA (GO:0000460)2.92863419
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91585715
115* mitotic nuclear division (GO:0007067)2.91538582
116DNA packaging (GO:0006323)2.91139716
117IMP metabolic process (GO:0046040)2.88104091
118transcription-coupled nucleotide-excision repair (GO:0006283)2.87685871
119protein complex localization (GO:0031503)2.86888890
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86512342
121negative regulation of ligase activity (GO:0051352)2.86512342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05174989
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.91764100
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.08863024
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03762329
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.86532868
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44956984
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20569345
8* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.11445440
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95953303
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.83432039
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.78423261
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77710827
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75391257
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74422568
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72606426
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.61323616
17AR_21909140_ChIP-Seq_LNCAP_Human2.60207191
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42075972
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37546805
20XRN2_22483619_ChIP-Seq_HELA_Human2.32196424
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21463912
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20697607
23VDR_23849224_ChIP-Seq_CD4+_Human2.10652122
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10183399
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08569630
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06164995
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.98590205
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92964559
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92941280
30* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91889802
31DCP1A_22483619_ChIP-Seq_HELA_Human1.91759749
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88004343
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.83292199
34* GABP_19822575_ChIP-Seq_HepG2_Human1.80774792
35TTF2_22483619_ChIP-Seq_HELA_Human1.74463158
36* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73964857
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69148257
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63468552
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.62479973
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62111204
41* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61398887
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60920859
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58055683
44CIITA_25753668_ChIP-Seq_RAJI_Human1.54325831
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52183881
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.51547874
47KDM5A_27292631_Chip-Seq_BREAST_Human1.51187516
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45414927
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43407644
50ELK1_19687146_ChIP-ChIP_HELA_Human1.43150867
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42543822
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41989885
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39530335
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36506585
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36039002
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31372322
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29946139
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29703561
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29147016
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28297748
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26836619
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25299032
63MYC_22102868_ChIP-Seq_BL_Human1.25295513
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23048684
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22836005
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20223370
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19760784
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.19115625
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.13890785
70* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12856194
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11477987
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11020169
73* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10357086
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03956224
75TFEB_21752829_ChIP-Seq_HELA_Human1.03791874
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03610119
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03431286
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02918157
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.01113451
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.99516704
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97443278
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97403647
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96278063
84ZNF263_19887448_ChIP-Seq_K562_Human0.95967309
85RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94323637
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92418425
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91981535
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91860512
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91376551
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89851787
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88693881
92SALL1_21062744_ChIP-ChIP_HESCs_Human0.88635274
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88248206
94MYC_18940864_ChIP-ChIP_HL60_Human0.88138474
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87205762
96* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82961156
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82881396
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.82289623
99* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79572677
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79466194
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78344175
102OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77741689
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.77331198
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76711261
105* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76567127
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76406915
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75159147
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73875160
109CHD1_26751641_Chip-Seq_LNCaP_Human0.73665970
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72931064
111POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.72758187
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72513416
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.69934146
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.69934146
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.69934146
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68002652
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67898595
118* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66162315
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.65419712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003693_abnormal_embryo_hatching5.75917861
2* MP0003111_abnormal_nucleus_morphology5.29933377
3MP0004957_abnormal_blastocyst_morpholog4.75079967
4* MP0010094_abnormal_chromosome_stability4.70961587
5* MP0003077_abnormal_cell_cycle4.42643056
6MP0008057_abnormal_DNA_replication3.81990689
7MP0008058_abnormal_DNA_repair3.33706559
8MP0008007_abnormal_cellular_replicative2.99475190
9MP0008932_abnormal_embryonic_tissue2.92775087
10* MP0001730_embryonic_growth_arrest2.60618251
11MP0003718_maternal_effect2.60190087
12MP0003123_paternal_imprinting2.57630287
13MP0008877_abnormal_DNA_methylation2.33213631
14* MP0000350_abnormal_cell_proliferation2.32884669
15MP0003786_premature_aging2.16358882
16MP0010307_abnormal_tumor_latency2.13625233
17MP0003950_abnormal_plasma_membrane2.03355598
18MP0005380_embryogenesis_phenotype1.99890555
19MP0001672_abnormal_embryogenesis/_devel1.99890555
20MP0001697_abnormal_embryo_size1.92773802
21MP0010234_abnormal_vibrissa_follicle1.81306214
22MP0010352_gastrointestinal_tract_polyps1.76901056
23* MP0002080_prenatal_lethality1.75119015
24MP0009697_abnormal_copulation1.73364867
25MP0003984_embryonic_growth_retardation1.73208887
26MP0002085_abnormal_embryonic_tissue1.71244408
27MP0002088_abnormal_embryonic_growth/wei1.69355226
28MP0002396_abnormal_hematopoietic_system1.69349645
29MP0002210_abnormal_sex_determination1.59672935
30MP0008789_abnormal_olfactory_epithelium1.54713402
31MP0002084_abnormal_developmental_patter1.52902890
32MP0001929_abnormal_gametogenesis1.49386304
33MP0002086_abnormal_extraembryonic_tissu1.47201845
34MP0010030_abnormal_orbit_morphology1.45336943
35MP0000490_abnormal_crypts_of1.43641968
36* MP0000313_abnormal_cell_death1.43583170
37MP0001145_abnormal_male_reproductive1.40554074
38MP0003567_abnormal_fetal_cardiomyocyte1.39273252
39MP0003315_abnormal_perineum_morphology1.38962661
40* MP0002019_abnormal_tumor_incidence1.30468458
41MP0004197_abnormal_fetal_growth/weight/1.29599258
42MP0002653_abnormal_ependyma_morphology1.28854602
43MP0003806_abnormal_nucleotide_metabolis1.27128168
44MP0005076_abnormal_cell_differentiation1.24553164
45MP0002877_abnormal_melanocyte_morpholog1.23469575
46MP0000653_abnormal_sex_gland1.23259963
47MP0005394_taste/olfaction_phenotype1.20735904
48MP0005499_abnormal_olfactory_system1.20735904
49MP0004233_abnormal_muscle_weight1.19140992
50MP0001293_anophthalmia1.18364609
51MP0004808_abnormal_hematopoietic_stem1.15606730
52MP0005501_abnormal_skin_physiology1.14326922
53MP0003121_genomic_imprinting1.09897779
54MP0009333_abnormal_splenocyte_physiolog1.09423368
55MP0002160_abnormal_reproductive_system1.06815046
56MP0001545_abnormal_hematopoietic_system1.06467212
57MP0005397_hematopoietic_system_phenotyp1.06467212
58MP0000537_abnormal_urethra_morphology1.06417990
59MP0002234_abnormal_pharynx_morphology1.04164983
60MP0001346_abnormal_lacrimal_gland1.02733821
61MP0003890_abnormal_embryonic-extraembry1.02680324
62MP0003941_abnormal_skin_development0.99806783
63MP0002697_abnormal_eye_size0.98224075
64MP0003119_abnormal_digestive_system0.97778205
65MP0003937_abnormal_limbs/digits/tail_de0.97730108
66MP0009053_abnormal_anal_canal0.97714219
67MP0009672_abnormal_birth_weight0.96943884
68MP0000358_abnormal_cell_content/0.95853944
69MP0000762_abnormal_tongue_morphology0.94603881
70MP0003698_abnormal_male_reproductive0.93497596
71MP0005389_reproductive_system_phenotype0.93027581
72MP0002796_impaired_skin_barrier0.91550516
73MP0005360_urolithiasis0.88598650
74MP0001119_abnormal_female_reproductive0.88210395
75MP0002233_abnormal_nose_morphology0.88074080
76MP0006292_abnormal_olfactory_placode0.86661022
77MP0002132_abnormal_respiratory_system0.86086286
78MP0005384_cellular_phenotype0.85187099
79MP0002111_abnormal_tail_morphology0.85105391
80MP0005621_abnormal_cell_physiology0.82857726
81MP0005410_abnormal_fertilization0.82733855
82MP0008260_abnormal_autophagy0.81995108
83MP0002161_abnormal_fertility/fecundity0.81842349
84MP0003221_abnormal_cardiomyocyte_apopto0.80816919
85MP0000703_abnormal_thymus_morphology0.80488059
86MP0005395_other_phenotype0.79249296
87MP0003755_abnormal_palate_morphology0.78953759
88MP0003935_abnormal_craniofacial_develop0.73453402
89MP0000428_abnormal_craniofacial_morphol0.72559992
90MP0003699_abnormal_female_reproductive0.71263861
91MP0002722_abnormal_immune_system0.71103474
92MP0002938_white_spotting0.71078125
93MP0009703_decreased_birth_body0.70251349
94MP0000566_synostosis0.69984488
95MP0003878_abnormal_ear_physiology0.68705082
96MP0005377_hearing/vestibular/ear_phenot0.68705082
97MP0003656_abnormal_erythrocyte_physiolo0.68603695
98MP0005408_hypopigmentation0.68586074
99MP0006035_abnormal_mitochondrial_morpho0.68495716
100MP0002102_abnormal_ear_morphology0.68216631
101MP0005023_abnormal_wound_healing0.68209505
102MP0001849_ear_inflammation0.67888148
103MP0004133_heterotaxia0.67628442
104MP0003186_abnormal_redox_activity0.67465752
105MP0000627_abnormal_mammary_gland0.67353614
106MP0000647_abnormal_sebaceous_gland0.67281674
107MP0002092_abnormal_eye_morphology0.67189897
108MP0001919_abnormal_reproductive_system0.66930807
109MP0004185_abnormal_adipocyte_glucose0.66725515
110MP0001881_abnormal_mammary_gland0.66607336
111MP0010678_abnormal_skin_adnexa0.66251987
112MP0003705_abnormal_hypodermis_morpholog0.66038940
113MP0003861_abnormal_nervous_system0.65937794
114MP0000750_abnormal_muscle_regeneration0.65194872
115MP0003566_abnormal_cell_adhesion0.64553308
116MP0000689_abnormal_spleen_morphology0.64288110
117MP0002163_abnormal_gland_morphology0.63275092
118MP0000858_altered_metastatic_potential0.61981841
119MP0004264_abnormal_extraembryonic_tissu0.61601572
120MP0002398_abnormal_bone_marrow0.61362737
121MP0002098_abnormal_vibrissa_morphology0.61192170
122MP0003136_yellow_coat_color0.61114220
123MP0009278_abnormal_bone_marrow0.60159421
124MP0001915_intracranial_hemorrhage0.59341099
125MP0001286_abnormal_eye_development0.58760628
126MP0001727_abnormal_embryo_implantation0.57536746
127MP0005647_abnormal_sex_gland0.57429991
128MP0005197_abnormal_uvea_morphology0.57303012
129MP0000377_abnormal_hair_follicle0.56857110
130MP0005623_abnormal_meninges_morphology0.56059702
131MP0003938_abnormal_ear_development0.56046630
132MP0000432_abnormal_head_morphology0.54866630
133MP0003115_abnormal_respiratory_system0.53576488
134MP0000477_abnormal_intestine_morphology0.50577082
135MP0002429_abnormal_blood_cell0.49901312
136MP0009840_abnormal_foam_cell0.49874087

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.17933128
2Breast hypoplasia (HP:0003187)4.63059182
3Carpal bone hypoplasia (HP:0001498)4.21627435
4Chromsome breakage (HP:0040012)3.92463530
5Impulsivity (HP:0100710)3.91202565
6Patellar aplasia (HP:0006443)3.89030386
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87263427
8Aplasia/Hypoplasia of the patella (HP:0006498)3.70816533
9Selective tooth agenesis (HP:0001592)3.52801852
10Abnormality of the anterior horn cell (HP:0006802)3.52524410
11Degeneration of anterior horn cells (HP:0002398)3.52524410
12Reticulocytopenia (HP:0001896)3.43186710
13Volvulus (HP:0002580)3.38658197
14Meckel diverticulum (HP:0002245)3.37283201
15Oral leukoplakia (HP:0002745)3.36827087
16Rough bone trabeculation (HP:0100670)3.34638108
17Absent radius (HP:0003974)3.27158571
18Abnormality of the preputium (HP:0100587)3.20124183
19Cerebral hypomyelination (HP:0006808)3.19864914
20Abnormality of the ileum (HP:0001549)3.18628714
21Abnormality of chromosome stability (HP:0003220)3.09052742
22Aplasia involving forearm bones (HP:0009822)3.04515173
23Absent forearm bone (HP:0003953)3.04515173
24Small intestinal stenosis (HP:0012848)3.04387804
25Duodenal stenosis (HP:0100867)3.04387804
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.03813503
27Hypoplasia of the capital femoral epiphysis (HP:0003090)3.03081523
28Abnormality of the labia minora (HP:0012880)3.02789558
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.94543955
30Colon cancer (HP:0003003)2.94093637
31Abnormal gallbladder physiology (HP:0012438)2.85808091
32Cholecystitis (HP:0001082)2.85808091
33Ependymoma (HP:0002888)2.84315438
34Abnormality of cells of the erythroid lineage (HP:0012130)2.78298664
35Supernumerary spleens (HP:0009799)2.71637515
36Absent thumb (HP:0009777)2.71261095
37Abnormal number of erythroid precursors (HP:0012131)2.69753696
38Medulloblastoma (HP:0002885)2.69653478
39Abnormal lung lobation (HP:0002101)2.68484321
40Sloping forehead (HP:0000340)2.65573301
41Premature ovarian failure (HP:0008209)2.64026526
42Myelodysplasia (HP:0002863)2.59294420
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54960221
44Bone marrow hypocellularity (HP:0005528)2.51086513
45Neoplasm of the pancreas (HP:0002894)2.50721987
46Cortical dysplasia (HP:0002539)2.47960583
47Horseshoe kidney (HP:0000085)2.47140594
48Abnormality of the duodenum (HP:0002246)2.46967611
49Secondary amenorrhea (HP:0000869)2.44818566
50Ureteral duplication (HP:0000073)2.43041491
51Abnormal trabecular bone morphology (HP:0100671)2.42125584
52Ectopic kidney (HP:0000086)2.34880274
53Trismus (HP:0000211)2.34869402
54Agnosia (HP:0010524)2.33328325
55Macrocytic anemia (HP:0001972)2.32586901
56Multiple enchondromatosis (HP:0005701)2.31697484
57Microretrognathia (HP:0000308)2.31417495
58Rhabdomyosarcoma (HP:0002859)2.30475091
59Abnormality of the umbilical cord (HP:0010881)2.29854586
60Premature graying of hair (HP:0002216)2.27221352
61Increased nuchal translucency (HP:0010880)2.27156569
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.24446710
63Absent epiphyses (HP:0010577)2.24446710
64Choanal atresia (HP:0000453)2.22146918
65Tracheoesophageal fistula (HP:0002575)2.21747639
66Aplastic anemia (HP:0001915)2.20649797
67Abnormality of glycolysis (HP:0004366)2.20168795
68Atresia of the external auditory canal (HP:0000413)2.17190479
6911 pairs of ribs (HP:0000878)2.17052166
70Facial hemangioma (HP:0000329)2.16759546
71Triphalangeal thumb (HP:0001199)2.14176562
72Duplicated collecting system (HP:0000081)2.13902746
73Cafe-au-lait spot (HP:0000957)2.13444692
74Atrophy/Degeneration involving motor neurons (HP:0007373)2.11339461
75Short thumb (HP:0009778)2.10095173
76Cellular immunodeficiency (HP:0005374)2.09016791
77Aplasia/hypoplasia of the humerus (HP:0006507)2.08611317
78Cleft eyelid (HP:0000625)2.08258464
79Abnormal number of incisors (HP:0011064)2.06274464
80Squamous cell carcinoma (HP:0002860)2.06230857
81Aplasia/Hypoplasia of the sternum (HP:0006714)2.06118565
82Abnormality of methionine metabolism (HP:0010901)2.03331785
83Abnormal spermatogenesis (HP:0008669)2.02193527
84Urethral obstruction (HP:0000796)2.02099050
85Increased serum pyruvate (HP:0003542)2.01948801
86Proximal placement of thumb (HP:0009623)2.00473980
87Duplication of thumb phalanx (HP:0009942)2.00379630
88Prominent nose (HP:0000448)2.00226694
89Papillary thyroid carcinoma (HP:0002895)1.99780242
90Abnormality of the fetal cardiovascular system (HP:0010948)1.98995663
91Abnormal umbilical cord blood vessels (HP:0011403)1.98995663
92Single umbilical artery (HP:0001195)1.98995663
93Embryonal neoplasm (HP:0002898)1.98509725
94Nephroblastoma (Wilms tumor) (HP:0002667)1.96844215
95Irregular epiphyses (HP:0010582)1.96721289
96Microvesicular hepatic steatosis (HP:0001414)1.95391201
97Pallor (HP:0000980)1.94699377
98Abnormality of the carotid arteries (HP:0005344)1.94544878
99Microglossia (HP:0000171)1.94146821
100Personality changes (HP:0000751)1.93775786
101Deviation of the thumb (HP:0009603)1.92485690
102Basal cell carcinoma (HP:0002671)1.92211110
103Overlapping toe (HP:0001845)1.91162405
104Neoplasm of the colon (HP:0100273)1.90113710
105Entropion (HP:0000621)1.89292612
106Breast aplasia (HP:0100783)1.88992171
107Absent septum pellucidum (HP:0001331)1.87477721
108Aplasia/Hypoplasia of the breasts (HP:0010311)1.87228773
109Megaloblastic anemia (HP:0001889)1.86562510
110Hypoplastic pelvis (HP:0008839)1.85882141
111Abnormality of the proximal phalanges of the hand (HP:0009834)1.85502838
112Abnormality of abdominal situs (HP:0011620)1.85325792
113Abdominal situs inversus (HP:0003363)1.85325792
114High pitched voice (HP:0001620)1.85274223
115Hypokinesia (HP:0002375)1.83905003
116Spinal muscular atrophy (HP:0007269)1.83890838
117Progressive muscle weakness (HP:0003323)1.83518365
118Intrahepatic cholestasis (HP:0001406)1.82226699
119Abnormality of the septum pellucidum (HP:0007375)1.82167131
120Facial cleft (HP:0002006)1.82047841
121CNS hypomyelination (HP:0003429)1.81832926
122Median cleft lip (HP:0000161)1.81121573
123Embryonal renal neoplasm (HP:0011794)1.81088533
124Oligodactyly (HP:0012165)1.81054668
125Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80610912
126Heterotopia (HP:0002282)1.79112550
127Oligodactyly (hands) (HP:0001180)1.78879180
128Broad distal phalanx of finger (HP:0009836)1.78808384
129Sparse eyelashes (HP:0000653)1.76359213
130Abnormality of the phalanges of the hallux (HP:0010057)1.76048905
131Capillary hemangiomas (HP:0005306)1.75569643
132Clubbing of toes (HP:0100760)1.74330411
133Ankle contracture (HP:0006466)1.74163736
134Arteriovenous malformation (HP:0100026)1.70714277
135Poikiloderma (HP:0001029)1.70524885
136Lip pit (HP:0100267)1.65992571
137Septo-optic dysplasia (HP:0100842)1.63587350
138Stillbirth (HP:0003826)1.61182744
139Abnormality of chromosome segregation (HP:0002916)1.61058189
140Deep philtrum (HP:0002002)1.60924776
141Hypergonadotropic hypogonadism (HP:0000815)1.59978980
142Abnormal foot bone ossification (HP:0010675)1.59512514
143Abnormal auditory evoked potentials (HP:0006958)1.57219008
144Conjunctival telangiectasia (HP:0000524)1.55861892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.67963617
2WEE15.01276855
3MAP3K94.43395781
4CDC73.51982764
5NEK23.39333395
6EIF2AK12.98259370
7TTK2.94094267
8BRSK22.66000106
9NEK12.63853033
10PLK42.48811311
11PLK12.35426493
12TSSK62.17188618
13SRPK12.14696161
14VRK22.02451948
15BRSK12.02126964
16TAF11.90742999
17TESK21.87243016
18AURKB1.83432390
19PLK31.82774097
20ARAF1.75860563
21STK161.65418112
22STK101.64061632
23EPHA21.62379840
24CCNB11.58417825
25ACVR1B1.57441880
26MAP3K81.57096678
27MKNK11.56958079
28CHEK21.53166592
29CDK71.49875542
30DYRK31.44994141
31EIF2AK31.42682281
32NME21.42071521
33VRK11.41453466
34TLK11.40686167
35ATR1.38750216
36MKNK21.37454784
37* AURKA1.30685368
38RPS6KB21.26297469
39STK41.22594471
40CDK41.21671781
41PNCK1.21583560
42CHEK11.21190761
43RPS6KA41.21079483
44MST1R1.20947875
45CDK121.18693431
46PDK41.17901905
47PDK31.17901905
48EEF2K1.14611973
49MET1.14342476
50SMG11.13207711
51MST41.11882725
52PASK1.09730219
53ZAK1.07014873
54TESK11.03463265
55TRIM281.02540051
56PAK41.02161291
57BRAF1.01787986
58CDK90.96626495
59MAP3K130.91857414
60MELK0.91393215
61STK30.89351198
62NEK90.83225624
63LATS20.79286007
64CDK20.79020569
65ATM0.77930532
66STK38L0.76300159
67EIF2AK20.75476862
68NEK60.74915988
69PBK0.73551043
70MOS0.67872273
71PDK20.67640845
72ERBB40.67244306
73RAF10.65116938
74* CDK10.63294471
75* PAK10.62742296
76PIM10.61342086
77KSR20.60369980
78PRKCI0.60354628
79ALK0.59877870
80MAP3K100.58613545
81AKT30.58254198
82CSNK2A10.56347604
83SCYL20.56187580
84PTK20.55192380
85CDK60.54697283
86CSNK2A20.52009242
87IRAK30.51669986
88KSR10.45551405
89STK240.44783892
90TGFBR10.43335208
91KDR0.42205324
92MAPKAPK30.38955344
93NUAK10.38241938
94PIM20.37954253
95CDK80.37250257
96RPS6KA50.36839069
97BRD40.36229921
98LRRK20.35628450
99MAP3K110.35500274
100MARK30.34423446
101MTOR0.33711636
102CSNK1E0.32004087
103AKT20.31957199
104ICK0.30335185
105TAOK20.23649886
106LATS10.23335370
107PRKDC0.22656340
108BCR0.22145925
109LIMK10.21685726
110DYRK20.21401983
111TNIK0.20509767
112CLK10.19495155
113ILK0.19210322
114MAP2K30.18234878
115NME10.18118417
116CSNK1G10.17912089
117FLT30.16887120
118CDK11A0.15690516
119MAPK140.15392152
120MAPKAPK20.14332145
121CDK150.13686344
122CDK180.10978629
123PKN20.10901193
124CDK140.10444368
125BCKDK0.10222201
126RPS6KA10.10101581
127PAK20.09599677

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58754228
2Mismatch repair_Homo sapiens_hsa034304.00075505
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85155318
4RNA transport_Homo sapiens_hsa030133.47302685
5RNA polymerase_Homo sapiens_hsa030203.35542301
6Proteasome_Homo sapiens_hsa030503.31584312
7Spliceosome_Homo sapiens_hsa030403.29437209
8Cell cycle_Homo sapiens_hsa041103.25903740
9Base excision repair_Homo sapiens_hsa034103.04585349
10Homologous recombination_Homo sapiens_hsa034403.03151180
11Nucleotide excision repair_Homo sapiens_hsa034202.81017781
12Ribosome_Homo sapiens_hsa030102.73902196
13One carbon pool by folate_Homo sapiens_hsa006702.46544321
14Pyrimidine metabolism_Homo sapiens_hsa002402.45238202
15Vitamin B6 metabolism_Homo sapiens_hsa007502.44923420
16Fanconi anemia pathway_Homo sapiens_hsa034602.43746143
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42245520
18Basal transcription factors_Homo sapiens_hsa030222.14851842
19p53 signaling pathway_Homo sapiens_hsa041151.94414129
20RNA degradation_Homo sapiens_hsa030181.84878588
21Non-homologous end-joining_Homo sapiens_hsa034501.77425672
22mRNA surveillance pathway_Homo sapiens_hsa030151.77284730
23* Oocyte meiosis_Homo sapiens_hsa041141.42810962
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40242350
25Purine metabolism_Homo sapiens_hsa002301.37187306
26Systemic lupus erythematosus_Homo sapiens_hsa053221.27208203
27Epstein-Barr virus infection_Homo sapiens_hsa051691.25875912
28Pyruvate metabolism_Homo sapiens_hsa006201.23830815
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22269282
30Pentose phosphate pathway_Homo sapiens_hsa000301.18192976
31Biosynthesis of amino acids_Homo sapiens_hsa012301.09115352
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.08714893
33Folate biosynthesis_Homo sapiens_hsa007901.04240113
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02436803
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98875902
36Viral carcinogenesis_Homo sapiens_hsa052030.98492507
37Selenocompound metabolism_Homo sapiens_hsa004500.96721412
38Steroid biosynthesis_Homo sapiens_hsa001000.84118112
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82218394
40Fatty acid elongation_Homo sapiens_hsa000620.81143949
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.80717429
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79793536
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78805286
44Antigen processing and presentation_Homo sapiens_hsa046120.78228912
45Herpes simplex infection_Homo sapiens_hsa051680.72583362
46HTLV-I infection_Homo sapiens_hsa051660.68686179
47Parkinsons disease_Homo sapiens_hsa050120.68660432
48Carbon metabolism_Homo sapiens_hsa012000.65339245
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62910980
50Glutathione metabolism_Homo sapiens_hsa004800.62226868
51Propanoate metabolism_Homo sapiens_hsa006400.62191847
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.60998870
53MicroRNAs in cancer_Homo sapiens_hsa052060.58269208
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57175599
55Fructose and mannose metabolism_Homo sapiens_hsa000510.57052863
56Sulfur relay system_Homo sapiens_hsa041220.56121303
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55479983
58Small cell lung cancer_Homo sapiens_hsa052220.53202720
59Oxidative phosphorylation_Homo sapiens_hsa001900.52894902
60Lysine degradation_Homo sapiens_hsa003100.50718657
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49894242
62Regulation of autophagy_Homo sapiens_hsa041400.48209899
63Hippo signaling pathway_Homo sapiens_hsa043900.46466536
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45971395
65Arginine biosynthesis_Homo sapiens_hsa002200.43496411
66Thyroid cancer_Homo sapiens_hsa052160.43183799
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41576852
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41449486
69Huntingtons disease_Homo sapiens_hsa050160.41341790
70Legionellosis_Homo sapiens_hsa051340.39151402
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36902236
72Wnt signaling pathway_Homo sapiens_hsa043100.36536530
73Alcoholism_Homo sapiens_hsa050340.36248170
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35940226
75Apoptosis_Homo sapiens_hsa042100.35399741
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35196573
77TGF-beta signaling pathway_Homo sapiens_hsa043500.32603897
78Basal cell carcinoma_Homo sapiens_hsa052170.32169565
79Pancreatic cancer_Homo sapiens_hsa052120.29908040
80Hedgehog signaling pathway_Homo sapiens_hsa043400.29799934
81Sulfur metabolism_Homo sapiens_hsa009200.27824531
82Bladder cancer_Homo sapiens_hsa052190.27593943
83Alzheimers disease_Homo sapiens_hsa050100.27545400
84HIF-1 signaling pathway_Homo sapiens_hsa040660.24820920
85Metabolic pathways_Homo sapiens_hsa011000.24544177
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24497328
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24309368
88Colorectal cancer_Homo sapiens_hsa052100.24125593
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23856634
90mTOR signaling pathway_Homo sapiens_hsa041500.23778519
91Proteoglycans in cancer_Homo sapiens_hsa052050.22658707
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.22527293
93Gap junction_Homo sapiens_hsa045400.21608564
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19422912
95Galactose metabolism_Homo sapiens_hsa000520.19299743
96Shigellosis_Homo sapiens_hsa051310.18677563
97Renin-angiotensin system_Homo sapiens_hsa046140.18517601
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17701591
99Vitamin digestion and absorption_Homo sapiens_hsa049770.17657142
100Notch signaling pathway_Homo sapiens_hsa043300.17572225
101Endometrial cancer_Homo sapiens_hsa052130.17303768
102Hepatitis B_Homo sapiens_hsa051610.17168223
103Protein export_Homo sapiens_hsa030600.16954101
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16930112
105Non-small cell lung cancer_Homo sapiens_hsa052230.16846381
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.15343307
107Arachidonic acid metabolism_Homo sapiens_hsa005900.14801819
108N-Glycan biosynthesis_Homo sapiens_hsa005100.14718814
109Melanoma_Homo sapiens_hsa052180.14673224
110Linoleic acid metabolism_Homo sapiens_hsa005910.14667104
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13938581
112Pathways in cancer_Homo sapiens_hsa052000.13872817
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13457749
114FoxO signaling pathway_Homo sapiens_hsa040680.12854485
115Arginine and proline metabolism_Homo sapiens_hsa003300.11843758
116Tight junction_Homo sapiens_hsa045300.11216774
117Adherens junction_Homo sapiens_hsa045200.10921707
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09798615
119Influenza A_Homo sapiens_hsa051640.09491082
120Chronic myeloid leukemia_Homo sapiens_hsa052200.08611917
121Prostate cancer_Homo sapiens_hsa052150.08010376
122Measles_Homo sapiens_hsa051620.06311982
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.04211223
124Primary immunodeficiency_Homo sapiens_hsa053400.03235695

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