

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.09849969 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.51208881 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 6.51208881 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.86810677 |
| 5 | respiratory electron transport chain (GO:0022904) | 5.52336366 |
| 6 | electron transport chain (GO:0022900) | 5.38523294 |
| 7 | proteasome assembly (GO:0043248) | 5.28344771 |
| 8 | ribosomal small subunit assembly (GO:0000028) | 5.23036555 |
| 9 | ribosomal small subunit biogenesis (GO:0042274) | 5.06771362 |
| 10 | viral transcription (GO:0019083) | 5.06307697 |
| 11 | translational termination (GO:0006415) | 4.91339180 |
| 12 | DNA deamination (GO:0045006) | 4.81910871 |
| 13 | protein maturation by protein folding (GO:0022417) | 4.76759033 |
| 14 | cotranslational protein targeting to membrane (GO:0006613) | 4.66536509 |
| 15 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.65688650 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.64712337 |
| 17 | protein targeting to ER (GO:0045047) | 4.59543363 |
| 18 | GDP-mannose metabolic process (GO:0019673) | 4.58975619 |
| 19 | chaperone-mediated protein transport (GO:0072321) | 4.57538531 |
| 20 | translational elongation (GO:0006414) | 4.44286005 |
| 21 | protein localization to endoplasmic reticulum (GO:0070972) | 4.43481570 |
| 22 | protein complex biogenesis (GO:0070271) | 4.42801916 |
| 23 | regulation of mitochondrial translation (GO:0070129) | 4.42230205 |
| 24 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.41495579 |
| 25 | NADH dehydrogenase complex assembly (GO:0010257) | 4.41495579 |
| 26 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.41495579 |
| 27 | oxidative phosphorylation (GO:0006119) | 4.40194552 |
| 28 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.36321888 |
| 29 | maturation of SSU-rRNA (GO:0030490) | 4.28349761 |
| 30 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.20501386 |
| 31 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.17621095 |
| 32 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.17027011 |
| 33 | ribosomal large subunit biogenesis (GO:0042273) | 4.13823122 |
| 34 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.13174185 |
| 35 | translation (GO:0006412) | 4.11856473 |
| 36 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 4.11416983 |
| 37 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.06379229 |
| 38 | termination of RNA polymerase III transcription (GO:0006386) | 4.06379229 |
| 39 | protein neddylation (GO:0045116) | 4.03937870 |
| 40 | translational initiation (GO:0006413) | 3.95330066 |
| 41 | viral life cycle (GO:0019058) | 3.94908549 |
| 42 | protein targeting to mitochondrion (GO:0006626) | 3.94321667 |
| 43 | establishment of protein localization to mitochondrion (GO:0072655) | 3.94072985 |
| 44 | cellular protein complex disassembly (GO:0043624) | 3.92970179 |
| 45 | GTP biosynthetic process (GO:0006183) | 3.86644359 |
| 46 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.85467836 |
| 47 | negative regulation of ligase activity (GO:0051352) | 3.84654078 |
| 48 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.84654078 |
| 49 | cullin deneddylation (GO:0010388) | 3.84369499 |
| 50 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.83740043 |
| 51 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.80897754 |
| 52 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.80791035 |
| 53 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.77920602 |
| 54 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.77353338 |
| 55 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.77353338 |
| 56 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.77194968 |
| 57 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.77194968 |
| 58 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.76593638 |
| 59 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.72257779 |
| 60 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.72257779 |
| 61 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.72257779 |
| 62 | protein deneddylation (GO:0000338) | 3.68125558 |
| 63 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.65465745 |
| 64 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.65465745 |
| 65 | protein localization to mitochondrion (GO:0070585) | 3.64984339 |
| 66 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.63239301 |
| 67 | NADH metabolic process (GO:0006734) | 3.61133703 |
| 68 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.60397424 |
| 69 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.60062043 |
| 70 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.59296362 |
| 71 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.58563085 |
| 72 | cellular component biogenesis (GO:0044085) | 3.54906282 |
| 73 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.54882481 |
| 74 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.53986554 |
| 75 | ATP biosynthetic process (GO:0006754) | 3.52898299 |
| 76 | formation of translation preinitiation complex (GO:0001731) | 3.51272354 |
| 77 | aldehyde catabolic process (GO:0046185) | 3.50587108 |
| 78 | UTP biosynthetic process (GO:0006228) | 3.49790856 |
| 79 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.49602235 |
| 80 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.48220000 |
| 81 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.47192168 |
| 82 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.46320860 |
| 83 | deoxyribonucleotide catabolic process (GO:0009264) | 3.45321950 |
| 84 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.42512597 |
| 85 | nucleotide salvage (GO:0043173) | 3.42262217 |
| 86 | 7-methylguanosine mRNA capping (GO:0006370) | 3.41656326 |
| 87 | respiratory chain complex IV assembly (GO:0008535) | 3.39916867 |
| 88 | iron-sulfur cluster assembly (GO:0016226) | 3.37461977 |
| 89 | metallo-sulfur cluster assembly (GO:0031163) | 3.37461977 |
| 90 | inner mitochondrial membrane organization (GO:0007007) | 3.36848673 |
| 91 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.36078784 |
| 92 | deoxyribose phosphate catabolic process (GO:0046386) | 3.35919428 |
| 93 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.34352728 |
| 94 | L-methionine salvage (GO:0071267) | 3.32396941 |
| 95 | L-methionine biosynthetic process (GO:0071265) | 3.32396941 |
| 96 | amino acid salvage (GO:0043102) | 3.32396941 |
| 97 | RNA capping (GO:0036260) | 3.31254302 |
| 98 | 7-methylguanosine RNA capping (GO:0009452) | 3.31254302 |
| 99 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.26955340 |
| 100 | protein complex disassembly (GO:0043241) | 3.26601090 |
| 101 | regulation of cellular amine metabolic process (GO:0033238) | 3.25348692 |
| 102 | mitotic nuclear envelope reassembly (GO:0007084) | 3.25090798 |
| 103 | nuclear envelope reassembly (GO:0031468) | 3.25090798 |
| 104 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.24742143 |
| 105 | mitochondrial transport (GO:0006839) | 3.22244966 |
| 106 | hydrogen ion transmembrane transport (GO:1902600) | 3.21681834 |
| 107 | base-excision repair, AP site formation (GO:0006285) | 3.21250043 |
| 108 | regulation of cellular respiration (GO:0043457) | 3.20986920 |
| 109 | UTP metabolic process (GO:0046051) | 3.20008076 |
| 110 | positive regulation of ligase activity (GO:0051351) | 3.19563016 |
| 111 | proline biosynthetic process (GO:0006561) | 3.19062036 |
| 112 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.18244887 |
| 113 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.15649400 |
| 114 | macromolecular complex disassembly (GO:0032984) | 3.15168957 |
| 115 | rRNA modification (GO:0000154) | 3.15122475 |
| 116 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.14512024 |
| 117 | CTP metabolic process (GO:0046036) | 3.13210007 |
| 118 | CTP biosynthetic process (GO:0006241) | 3.13210007 |
| 119 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 3.12515923 |
| 120 | cytochrome complex assembly (GO:0017004) | 3.09883216 |
| 121 | DNA strand elongation (GO:0022616) | 3.08968459 |
| 122 | pentose metabolic process (GO:0019321) | 3.07830399 |
| 123 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.07615753 |
| 124 | histone arginine methylation (GO:0034969) | 3.07518456 |
| 125 | pseudouridine synthesis (GO:0001522) | 3.07052929 |
| 126 | protein targeting to membrane (GO:0006612) | 3.05547050 |
| 127 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 3.04537455 |
| 128 | establishment of viral latency (GO:0019043) | 3.03665483 |
| 129 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.03550044 |
| 130 | establishment of integrated proviral latency (GO:0075713) | 3.02487803 |
| 131 | ribosome biogenesis (GO:0042254) | 3.02140707 |
| 132 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.01500981 |
| 133 | nucleoside salvage (GO:0043174) | 3.00987344 |
| 134 | aerobic respiration (GO:0009060) | 3.00126805 |
| 135 | rRNA processing (GO:0006364) | 2.99176302 |
| 136 | purine nucleotide salvage (GO:0032261) | 2.98680917 |
| 137 | transcription from mitochondrial promoter (GO:0006390) | 2.98488801 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.66050954 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.20297960 |
| 3 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.15270522 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.14128263 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.10212481 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.03388113 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.97632853 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.91388217 |
| 9 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.71800707 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.50533528 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.41962580 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.13977039 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.10719783 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.96834977 |
| 15 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.81651512 |
| 16 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.65811850 |
| 17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.64336520 |
| 18 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.55830199 |
| 19 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.50520862 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.50483492 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.49657318 |
| 22 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.49431755 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.46632543 |
| 24 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.42647016 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.40788734 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.37845992 |
| 27 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.35413050 |
| 28 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.22168038 |
| 29 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.14650820 |
| 30 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.08719208 |
| 31 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.05914315 |
| 32 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.01555893 |
| 33 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.96684483 |
| 34 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.88537833 |
| 35 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.87640965 |
| 36 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.85036065 |
| 37 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.83544258 |
| 38 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.83475541 |
| 39 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.80351021 |
| 40 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.79019596 |
| 41 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.76205476 |
| 42 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.72742903 |
| 43 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.68811718 |
| 44 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.66386746 |
| 45 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.64109823 |
| 46 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63662242 |
| 47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.59329847 |
| 48 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.55853328 |
| 49 | MYC_22102868_ChIP-Seq_BL_Human | 1.53447572 |
| 50 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.50223131 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.49562835 |
| 52 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48489498 |
| 53 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.46266894 |
| 54 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.45168015 |
| 55 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.44595284 |
| 56 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.44488284 |
| 57 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.43357972 |
| 58 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.42548768 |
| 59 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.41935552 |
| 60 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.41488910 |
| 61 | P68_20966046_ChIP-Seq_HELA_Human | 1.41443226 |
| 62 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.39925572 |
| 63 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.37733489 |
| 64 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.35389731 |
| 65 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.34636446 |
| 66 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.34122068 |
| 67 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.33122719 |
| 68 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.32894714 |
| 69 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.31720948 |
| 70 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.29525867 |
| 71 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.29049906 |
| 72 | * ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.28864901 |
| 73 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.28250422 |
| 74 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.25146371 |
| 75 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.23871962 |
| 76 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.23343691 |
| 77 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.22602427 |
| 78 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.21104488 |
| 79 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.19410157 |
| 80 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.18362299 |
| 81 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.17844728 |
| 82 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.17224667 |
| 83 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.15805923 |
| 84 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.14980041 |
| 85 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.14811802 |
| 86 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.13727651 |
| 87 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.12529414 |
| 88 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.11834894 |
| 89 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.10837426 |
| 90 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.10061799 |
| 91 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.09221446 |
| 92 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.06830243 |
| 93 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.05183260 |
| 94 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.04822772 |
| 95 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.04248129 |
| 96 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04184662 |
| 97 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.03355495 |
| 98 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.03351264 |
| 99 | * MAF_26560356_Chip-Seq_TH2_Human | 1.03340768 |
| 100 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.02884729 |
| 101 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.01998207 |
| 102 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.01884625 |
| 103 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.01328260 |
| 104 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.01224653 |
| 105 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.98821060 |
| 106 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.97636145 |
| 107 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.96429187 |
| 108 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.95641930 |
| 109 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.94902177 |
| 110 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.93388944 |
| 111 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.91890423 |
| 112 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.91845973 |
| 113 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.89278809 |
| 114 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.87311752 |
| 115 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.86381214 |
| 116 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.85821237 |
| 117 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.84969620 |
| 118 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.84109239 |
| 119 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.83748603 |
| 120 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.82526483 |
| 121 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.82201982 |
| 122 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.81276726 |
| 123 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.80362548 |
| 124 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.79698786 |
| 125 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.79134865 |
| 126 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.78805956 |
| 127 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.76959543 |
| 128 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.76702233 |
| 129 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.75985906 |
| 130 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.75175332 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 5.19242317 |
| 2 | MP0006036_abnormal_mitochondrial_physio | 3.82959843 |
| 3 | MP0009379_abnormal_foot_pigmentation | 3.61673706 |
| 4 | MP0001529_abnormal_vocalization | 3.52518585 |
| 5 | MP0003186_abnormal_redox_activity | 3.33092324 |
| 6 | MP0003693_abnormal_embryo_hatching | 3.02327598 |
| 7 | MP0006035_abnormal_mitochondrial_morpho | 2.88688632 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.83056720 |
| 9 | MP0002139_abnormal_hepatobiliary_system | 2.70548342 |
| 10 | MP0004858_abnormal_nervous_system | 2.33463818 |
| 11 | MP0005670_abnormal_white_adipose | 2.30800014 |
| 12 | MP0001764_abnormal_homeostasis | 2.22277974 |
| 13 | MP0008057_abnormal_DNA_replication | 2.16411646 |
| 14 | MP0001905_abnormal_dopamine_level | 2.13992447 |
| 15 | MP0000678_abnormal_parathyroid_gland | 2.12376042 |
| 16 | MP0005083_abnormal_biliary_tract | 2.10362768 |
| 17 | MP0003718_maternal_effect | 2.05763264 |
| 18 | MP0005360_urolithiasis | 2.00562538 |
| 19 | MP0004185_abnormal_adipocyte_glucose | 2.00249200 |
| 20 | MP0004142_abnormal_muscle_tone | 1.97446274 |
| 21 | MP0008007_abnormal_cellular_replicative | 1.97078372 |
| 22 | MP0005332_abnormal_amino_acid | 1.94787280 |
| 23 | MP0004147_increased_porphyrin_level | 1.94019136 |
| 24 | MP0005085_abnormal_gallbladder_physiolo | 1.89159963 |
| 25 | MP0008932_abnormal_embryonic_tissue | 1.87803956 |
| 26 | MP0003656_abnormal_erythrocyte_physiolo | 1.87769465 |
| 27 | MP0003646_muscle_fatigue | 1.82328843 |
| 28 | MP0002837_dystrophic_cardiac_calcinosis | 1.80129851 |
| 29 | MP0003195_calcinosis | 1.80000627 |
| 30 | MP0004233_abnormal_muscle_weight | 1.78169183 |
| 31 | MP0008875_abnormal_xenobiotic_pharmacok | 1.77456847 |
| 32 | MP0002877_abnormal_melanocyte_morpholog | 1.76883970 |
| 33 | MP0005501_abnormal_skin_physiology | 1.75050738 |
| 34 | MP0005408_hypopigmentation | 1.65756838 |
| 35 | MP0005365_abnormal_bile_salt | 1.63009513 |
| 36 | MP0010030_abnormal_orbit_morphology | 1.61555644 |
| 37 | MP0005266_abnormal_metabolism | 1.57557915 |
| 38 | MP0003136_yellow_coat_color | 1.52391233 |
| 39 | MP0005075_abnormal_melanosome_morpholog | 1.51048244 |
| 40 | MP0002796_impaired_skin_barrier | 1.49543871 |
| 41 | MP0008058_abnormal_DNA_repair | 1.48254023 |
| 42 | MP0006276_abnormal_autonomic_nervous | 1.48007135 |
| 43 | MP0005636_abnormal_mineral_homeostasis | 1.47179075 |
| 44 | MP0005451_abnormal_body_composition | 1.45860078 |
| 45 | MP0003077_abnormal_cell_cycle | 1.45847937 |
| 46 | MP0000358_abnormal_cell_content/ | 1.44155423 |
| 47 | MP0000751_myopathy | 1.44041082 |
| 48 | MP0009333_abnormal_splenocyte_physiolog | 1.42861904 |
| 49 | MP0001986_abnormal_taste_sensitivity | 1.40341254 |
| 50 | MP0001666_abnormal_nutrient_absorption | 1.38524600 |
| 51 | MP0003011_delayed_dark_adaptation | 1.37472302 |
| 52 | MP0000350_abnormal_cell_proliferation | 1.36427730 |
| 53 | MP0005666_abnormal_adipose_tissue | 1.36244487 |
| 54 | MP0002132_abnormal_respiratory_system | 1.36157675 |
| 55 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.31512840 |
| 56 | MP0000490_abnormal_crypts_of | 1.28809367 |
| 57 | MP0001727_abnormal_embryo_implantation | 1.27595737 |
| 58 | MP0010094_abnormal_chromosome_stability | 1.27392287 |
| 59 | MP0009840_abnormal_foam_cell | 1.24708809 |
| 60 | MP0005376_homeostasis/metabolism_phenot | 1.24047072 |
| 61 | MP0009697_abnormal_copulation | 1.20346913 |
| 62 | MP0003786_premature_aging | 1.19706880 |
| 63 | MP0003880_abnormal_central_pattern | 1.19372683 |
| 64 | MP0008260_abnormal_autophagy | 1.18770432 |
| 65 | MP0009785_altered_susceptibility_to | 1.18576778 |
| 66 | MP0000759_abnormal_skeletal_muscle | 1.18311931 |
| 67 | MP0005623_abnormal_meninges_morphology | 1.15841607 |
| 68 | MP0001661_extended_life_span | 1.15828077 |
| 69 | MP0005319_abnormal_enzyme/_coenzyme | 1.13808305 |
| 70 | MP0002736_abnormal_nociception_after | 1.12842440 |
| 71 | MP0004510_myositis | 1.11172708 |
| 72 | MP0002249_abnormal_larynx_morphology | 1.10503538 |
| 73 | MP0002876_abnormal_thyroid_physiology | 1.10309090 |
| 74 | MP0008872_abnormal_physiological_respon | 1.08855521 |
| 75 | MP0005058_abnormal_lysosome_morphology | 1.06852691 |
| 76 | MP0000749_muscle_degeneration | 1.06738012 |
| 77 | MP0003075_altered_response_to | 1.05745773 |
| 78 | MP0009278_abnormal_bone_marrow | 1.04720613 |
| 79 | MP0002019_abnormal_tumor_incidence | 1.04298925 |
| 80 | MP0003111_abnormal_nucleus_morphology | 1.02468570 |
| 81 | MP0005375_adipose_tissue_phenotype | 1.01972582 |
| 82 | MP0003191_abnormal_cellular_cholesterol | 1.01712482 |
| 83 | MP0002080_prenatal_lethality | 1.01615313 |
| 84 | MP0002332_abnormal_exercise_endurance | 1.00806007 |
| 85 | MP0003123_paternal_imprinting | 0.99907506 |
| 86 | MP0009643_abnormal_urine_homeostasis | 0.98980694 |
| 87 | MP0000681_abnormal_thyroid_gland | 0.97077469 |
| 88 | MP0008469_abnormal_protein_level | 0.96778592 |
| 89 | MP0001881_abnormal_mammary_gland | 0.94698570 |
| 90 | MP0006082_CNS_inflammation | 0.93896256 |
| 91 | MP0005084_abnormal_gallbladder_morpholo | 0.92726388 |
| 92 | MP0005330_cardiomyopathy | 0.91360144 |
| 93 | MP0003453_abnormal_keratinocyte_physiol | 0.91102678 |
| 94 | MP0000372_irregular_coat_pigmentation | 0.87293643 |
| 95 | MP0003705_abnormal_hypodermis_morpholog | 0.87237950 |
| 96 | MP0004145_abnormal_muscle_electrophysio | 0.87214343 |
| 97 | MP0001542_abnormal_bone_strength | 0.85783311 |
| 98 | MP0005165_increased_susceptibility_to | 0.85186068 |
| 99 | MP0000733_abnormal_muscle_development | 0.84794609 |
| 100 | MP0003436_decreased_susceptibility_to | 0.82805572 |
| 101 | MP0005410_abnormal_fertilization | 0.82136746 |
| 102 | MP0003221_abnormal_cardiomyocyte_apopto | 0.81749837 |
| 103 | MP0001853_heart_inflammation | 0.80047744 |
| 104 | MP0005166_decreased_susceptibility_to | 0.79188430 |
| 105 | MP0001873_stomach_inflammation | 0.79003209 |
| 106 | MP0005025_abnormal_response_to | 0.78068907 |
| 107 | MP0009672_abnormal_birth_weight | 0.78035770 |
| 108 | MP0000747_muscle_weakness | 0.77718848 |
| 109 | MP0001730_embryonic_growth_arrest | 0.77611341 |
| 110 | MP0000003_abnormal_adipose_tissue | 0.77586453 |
| 111 | MP0002148_abnormal_hypersensitivity_rea | 0.77306415 |
| 112 | MP0004043_abnormal_pH_regulation | 0.77227298 |
| 113 | MP0000750_abnormal_muscle_regeneration | 0.74725168 |
| 114 | MP0002751_abnormal_autonomic_nervous | 0.74508713 |
| 115 | MP0002638_abnormal_pupillary_reflex | 0.74475964 |
| 116 | MP0003724_increased_susceptibility_to | 0.74234770 |
| 117 | MP0008873_increased_physiological_sensi | 0.73767491 |
| 118 | MP0004087_abnormal_muscle_fiber | 0.72736999 |
| 119 | MP0009053_abnormal_anal_canal | 0.72088874 |
| 120 | MP0004381_abnormal_hair_follicle | 0.71428730 |
| 121 | MP0002163_abnormal_gland_morphology | 0.70367756 |
| 122 | MP0005671_abnormal_response_to | 0.70087018 |
| 123 | MP0000537_abnormal_urethra_morphology | 0.69705757 |
| 124 | MP0003329_amyloid_beta_deposits | 0.69643814 |
| 125 | MP0001346_abnormal_lacrimal_gland | 0.68857297 |
| 126 | MP0002118_abnormal_lipid_homeostasis | 0.68511724 |
| 127 | MP0000920_abnormal_myelination | 0.68330130 |
| 128 | MP0005535_abnormal_body_temperature | 0.67628456 |
| 129 | MP0002822_catalepsy | 0.67314437 |
| 130 | MP0000313_abnormal_cell_death | 0.67173511 |
| 131 | MP0010307_abnormal_tumor_latency | 0.66843125 |
| 132 | MP0002429_abnormal_blood_cell | 0.66818106 |
| 133 | MP0000858_altered_metastatic_potential | 0.64548044 |
| 134 | MP0000703_abnormal_thymus_morphology | 0.63957071 |
| 135 | MP0001697_abnormal_embryo_size | 0.63657125 |
| 136 | MP0004019_abnormal_vitamin_homeostasis | 0.62602471 |
| 137 | MP0000689_abnormal_spleen_morphology | 0.61341240 |
| 138 | MP0002234_abnormal_pharynx_morphology | 0.60702427 |
| 139 | MP0002722_abnormal_immune_system | 0.60097582 |
| 140 | MP0005464_abnormal_platelet_physiology | 0.60011717 |
| 141 | MP0000609_abnormal_liver_physiology | 0.59454495 |
| 142 | MP0003941_abnormal_skin_development | 0.59059974 |
| 143 | MP0005384_cellular_phenotype | 0.58434558 |
| 144 | MP0002269_muscular_atrophy | 0.58348092 |
| 145 | MP0000343_altered_response_to | 0.57643478 |
| 146 | MP0010329_abnormal_lipoprotein_level | 0.56977231 |
| 147 | MP0003315_abnormal_perineum_morphology | 0.54540325 |
| 148 | MP0009765_abnormal_xenobiotic_induced | 0.53399383 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.38359301 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.98069908 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.78258222 |
| 4 | Hepatocellular necrosis (HP:0001404) | 5.67219406 |
| 5 | Acute encephalopathy (HP:0006846) | 5.66623740 |
| 6 | Hepatic necrosis (HP:0002605) | 5.29256396 |
| 7 | Increased CSF lactate (HP:0002490) | 5.20343726 |
| 8 | Progressive macrocephaly (HP:0004481) | 5.16851878 |
| 9 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.59377622 |
| 10 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.59377622 |
| 11 | Abnormality of glycolysis (HP:0004366) | 4.45906434 |
| 12 | Increased serum pyruvate (HP:0003542) | 4.45906434 |
| 13 | Cerebral edema (HP:0002181) | 4.35305508 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 4.26698714 |
| 15 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.25376333 |
| 16 | 3-Methylglutaconic aciduria (HP:0003535) | 4.17864191 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 4.06287061 |
| 18 | Abnormal number of erythroid precursors (HP:0012131) | 4.02553146 |
| 19 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.98099097 |
| 20 | Increased serum lactate (HP:0002151) | 3.96568650 |
| 21 | Lactic acidosis (HP:0003128) | 3.95153099 |
| 22 | Respiratory failure (HP:0002878) | 3.88917754 |
| 23 | Renal Fanconi syndrome (HP:0001994) | 3.72950348 |
| 24 | Increased intramyocellular lipid droplets (HP:0012240) | 3.71345686 |
| 25 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.59065230 |
| 26 | Exercise intolerance (HP:0003546) | 3.54372240 |
| 27 | Increased muscle lipid content (HP:0009058) | 3.41894504 |
| 28 | Leukodystrophy (HP:0002415) | 3.39914945 |
| 29 | Progressive muscle weakness (HP:0003323) | 3.31423151 |
| 30 | Cerebral hypomyelination (HP:0006808) | 3.27256807 |
| 31 | CNS demyelination (HP:0007305) | 3.20621466 |
| 32 | Reticulocytopenia (HP:0001896) | 3.19386074 |
| 33 | Optic disc pallor (HP:0000543) | 3.03882400 |
| 34 | Macrocytic anemia (HP:0001972) | 3.03672398 |
| 35 | Lethargy (HP:0001254) | 3.00141141 |
| 36 | Testicular atrophy (HP:0000029) | 2.92061026 |
| 37 | Myopathic facies (HP:0002058) | 2.87536221 |
| 38 | Exertional dyspnea (HP:0002875) | 2.82562065 |
| 39 | Emotional lability (HP:0000712) | 2.76713525 |
| 40 | Microretrognathia (HP:0000308) | 2.73848953 |
| 41 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.61299044 |
| 42 | Respiratory difficulties (HP:0002880) | 2.57462199 |
| 43 | Trismus (HP:0000211) | 2.52873968 |
| 44 | Microvesicular hepatic steatosis (HP:0001414) | 2.50699694 |
| 45 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.49046523 |
| 46 | Dicarboxylic aciduria (HP:0003215) | 2.49046523 |
| 47 | Abnormality of urine glucose concentration (HP:0011016) | 2.48872271 |
| 48 | Glycosuria (HP:0003076) | 2.48872271 |
| 49 | Distal lower limb muscle weakness (HP:0009053) | 2.48809526 |
| 50 | Hypertensive crisis (HP:0100735) | 2.48108118 |
| 51 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.42687260 |
| 52 | Neuroendocrine neoplasm (HP:0100634) | 2.41967656 |
| 53 | Achilles tendon contracture (HP:0001771) | 2.41690775 |
| 54 | Vertebral compression fractures (HP:0002953) | 2.41402388 |
| 55 | Pallor (HP:0000980) | 2.40133337 |
| 56 | Methylmalonic aciduria (HP:0012120) | 2.39091299 |
| 57 | Hyperthyroidism (HP:0000836) | 2.38080608 |
| 58 | Abnormality of renal resorption (HP:0011038) | 2.35655071 |
| 59 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.32570791 |
| 60 | Hypokinesia (HP:0002375) | 2.28007679 |
| 61 | Generalized aminoaciduria (HP:0002909) | 2.25474087 |
| 62 | Reduced antithrombin III activity (HP:0001976) | 2.25272237 |
| 63 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.24573644 |
| 64 | Hyperglycinemia (HP:0002154) | 2.23521136 |
| 65 | Hyperphosphaturia (HP:0003109) | 2.21187592 |
| 66 | Oral leukoplakia (HP:0002745) | 2.20755506 |
| 67 | Pheochromocytoma (HP:0002666) | 2.20489005 |
| 68 | Multiple enchondromatosis (HP:0005701) | 2.19338412 |
| 69 | Broad distal phalanx of finger (HP:0009836) | 2.17220489 |
| 70 | Abnormality of the Achilles tendon (HP:0005109) | 2.16596943 |
| 71 | Truncus arteriosus (HP:0001660) | 2.16050773 |
| 72 | Vomiting (HP:0002013) | 2.15303072 |
| 73 | Type I transferrin isoform profile (HP:0003642) | 2.11211754 |
| 74 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.09839051 |
| 75 | Abnormal trabecular bone morphology (HP:0100671) | 2.09078384 |
| 76 | Gliosis (HP:0002171) | 2.08620049 |
| 77 | CNS hypomyelination (HP:0003429) | 2.06641266 |
| 78 | Spastic paraparesis (HP:0002313) | 2.04084993 |
| 79 | Nausea (HP:0002018) | 2.00582895 |
| 80 | Fasciculations (HP:0002380) | 2.00142946 |
| 81 | Prolonged neonatal jaundice (HP:0006579) | 1.99249473 |
| 82 | Abnormality of alanine metabolism (HP:0010916) | 1.98130675 |
| 83 | Hyperalaninemia (HP:0003348) | 1.98130675 |
| 84 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.98130675 |
| 85 | Abnormality of the umbilical cord (HP:0010881) | 1.96994070 |
| 86 | Chronic obstructive pulmonary disease (HP:0006510) | 1.96528697 |
| 87 | Obstructive lung disease (HP:0006536) | 1.96528697 |
| 88 | Nemaline bodies (HP:0003798) | 1.94901443 |
| 89 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.93658440 |
| 90 | Abnormality of glycine metabolism (HP:0010895) | 1.93658440 |
| 91 | Ragged-red muscle fibers (HP:0003200) | 1.93467858 |
| 92 | Bulbar palsy (HP:0001283) | 1.92701715 |
| 93 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.92064086 |
| 94 | Hyperglycinuria (HP:0003108) | 1.90765279 |
| 95 | Delusions (HP:0000746) | 1.90349280 |
| 96 | Muscle fiber inclusion bodies (HP:0100299) | 1.89655264 |
| 97 | Hyperammonemia (HP:0001987) | 1.86968115 |
| 98 | Hypobetalipoproteinemia (HP:0003563) | 1.85272404 |
| 99 | Muscle stiffness (HP:0003552) | 1.84501695 |
| 100 | Aplastic anemia (HP:0001915) | 1.83875682 |
| 101 | Axonal loss (HP:0003447) | 1.83427896 |
| 102 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.83395554 |
| 103 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.81465792 |
| 104 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.81465792 |
| 105 | Abnormality of glycolipid metabolism (HP:0010969) | 1.81465792 |
| 106 | Abnormality of the tricuspid valve (HP:0001702) | 1.81414728 |
| 107 | Stridor (HP:0010307) | 1.80617326 |
| 108 | Seborrheic dermatitis (HP:0001051) | 1.80480405 |
| 109 | Neoplasm of head and neck (HP:0012288) | 1.80178482 |
| 110 | Esophageal neoplasm (HP:0100751) | 1.80178482 |
| 111 | Opisthotonus (HP:0002179) | 1.79556866 |
| 112 | Hepatosplenomegaly (HP:0001433) | 1.78839176 |
| 113 | Degeneration of anterior horn cells (HP:0002398) | 1.77889859 |
| 114 | Abnormality of the anterior horn cell (HP:0006802) | 1.77889859 |
| 115 | Abnormal gallbladder physiology (HP:0012438) | 1.77757504 |
| 116 | Cholecystitis (HP:0001082) | 1.77757504 |
| 117 | Abnormality of serum amino acid levels (HP:0003112) | 1.77555830 |
| 118 | Rough bone trabeculation (HP:0100670) | 1.77251444 |
| 119 | Poor suck (HP:0002033) | 1.76794714 |
| 120 | Pancytopenia (HP:0001876) | 1.76408009 |
| 121 | Carpal bone hypoplasia (HP:0001498) | 1.75587078 |
| 122 | Birth length less than 3rd percentile (HP:0003561) | 1.75324911 |
| 123 | Petechiae (HP:0000967) | 1.74926923 |
| 124 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.74844667 |
| 125 | Blindness (HP:0000618) | 1.74585211 |
| 126 | Selective tooth agenesis (HP:0001592) | 1.74442208 |
| 127 | Abnormality of placental membranes (HP:0011409) | 1.74425023 |
| 128 | Amniotic constriction ring (HP:0009775) | 1.74425023 |
| 129 | Cerebral palsy (HP:0100021) | 1.74101115 |
| 130 | Sparse eyelashes (HP:0000653) | 1.73781235 |
| 131 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.71643712 |
| 132 | Abnormal urine phosphate concentration (HP:0012599) | 1.71301094 |
| 133 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.70950754 |
| 134 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.70950754 |
| 135 | Abnormal protein glycosylation (HP:0012346) | 1.70950754 |
| 136 | Abnormal glycosylation (HP:0012345) | 1.70950754 |
| 137 | Postnatal microcephaly (HP:0005484) | 1.70687258 |
| 138 | Rhabdomyolysis (HP:0003201) | 1.70028714 |
| 139 | Breast hypoplasia (HP:0003187) | 1.69228208 |
| 140 | Methylmalonic acidemia (HP:0002912) | 1.68875747 |
| 141 | Abnormal pupillary function (HP:0007686) | 1.68804741 |
| 142 | Brushfield spots (HP:0001088) | 1.68065427 |
| 143 | X-linked dominant inheritance (HP:0001423) | 1.66677158 |
| 144 | Metabolic acidosis (HP:0001942) | 1.65781647 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.40735090 |
| 2 | BUB1 | 4.09945306 |
| 3 | NME2 | 3.90546319 |
| 4 | STK16 | 3.77303776 |
| 5 | BCKDK | 3.28807767 |
| 6 | EIF2AK1 | 3.19760117 |
| 7 | TLK1 | 3.08963639 |
| 8 | SMG1 | 2.87657035 |
| 9 | NME1 | 2.83662655 |
| 10 | TESK2 | 2.74597738 |
| 11 | MAP3K12 | 2.65228562 |
| 12 | WEE1 | 2.63075844 |
| 13 | PBK | 2.30213632 |
| 14 | ARAF | 2.22314193 |
| 15 | TRIB3 | 2.19530399 |
| 16 | MAP3K11 | 1.96505836 |
| 17 | SRPK1 | 1.93146498 |
| 18 | EIF2AK3 | 1.91958854 |
| 19 | CDK19 | 1.88246359 |
| 20 | VRK1 | 1.87364236 |
| 21 | TSSK6 | 1.84808187 |
| 22 | ERN1 | 1.84635777 |
| 23 | LIMK1 | 1.83398593 |
| 24 | PIM2 | 1.81272595 |
| 25 | MST4 | 1.77207941 |
| 26 | MYLK | 1.68449419 |
| 27 | TESK1 | 1.66347728 |
| 28 | STK39 | 1.65226878 |
| 29 | BRAF | 1.51466930 |
| 30 | KDR | 1.39419905 |
| 31 | OXSR1 | 1.28710347 |
| 32 | PAK4 | 1.20080991 |
| 33 | ABL2 | 1.19451148 |
| 34 | AURKA | 1.19140526 |
| 35 | MAP2K3 | 1.10667882 |
| 36 | WNK4 | 1.02557807 |
| 37 | IRAK3 | 1.02231612 |
| 38 | TTN | 0.97271022 |
| 39 | PDK2 | 0.96206047 |
| 40 | PRPF4B | 0.96041918 |
| 41 | BLK | 0.93156735 |
| 42 | DAPK3 | 0.91701758 |
| 43 | PRKD3 | 0.89401277 |
| 44 | MAP3K3 | 0.86206060 |
| 45 | PDK4 | 0.84627151 |
| 46 | PDK3 | 0.84627151 |
| 47 | PNCK | 0.84102822 |
| 48 | TAOK1 | 0.83418422 |
| 49 | PLK4 | 0.83282839 |
| 50 | ILK | 0.81199493 |
| 51 | CSNK1G3 | 0.80784296 |
| 52 | MAP2K6 | 0.77266440 |
| 53 | GRK6 | 0.77075775 |
| 54 | ADRBK2 | 0.76659869 |
| 55 | SIK1 | 0.76560992 |
| 56 | CASK | 0.76388348 |
| 57 | MAP4K1 | 0.76010779 |
| 58 | IRAK4 | 0.75834910 |
| 59 | CCNB1 | 0.75678249 |
| 60 | PLK1 | 0.73902658 |
| 61 | ZAP70 | 0.73014689 |
| 62 | CSNK2A2 | 0.71982347 |
| 63 | CSNK2A1 | 0.70520186 |
| 64 | BRSK2 | 0.70067368 |
| 65 | DYRK2 | 0.69400835 |
| 66 | SCYL2 | 0.68191991 |
| 67 | AKT2 | 0.67485725 |
| 68 | IRAK2 | 0.67135951 |
| 69 | OBSCN | 0.66481120 |
| 70 | PAK1 | 0.65785809 |
| 71 | MAPKAPK5 | 0.64638548 |
| 72 | RPS6KB2 | 0.63880223 |
| 73 | MAPKAPK3 | 0.63177871 |
| 74 | CHEK2 | 0.63139072 |
| 75 | ICK | 0.62315429 |
| 76 | NEK1 | 0.60575616 |
| 77 | TAF1 | 0.60142673 |
| 78 | IRAK1 | 0.59779063 |
| 79 | BCR | 0.59483922 |
| 80 | CAMK2G | 0.59108352 |
| 81 | GRK7 | 0.57130273 |
| 82 | GRK5 | 0.57042379 |
| 83 | AURKB | 0.56600644 |
| 84 | TXK | 0.54825753 |
| 85 | DYRK3 | 0.54352292 |
| 86 | RPS6KA5 | 0.52602754 |
| 87 | PRKCI | 0.51403799 |
| 88 | MOS | 0.49870643 |
| 89 | TAOK2 | 0.49636017 |
| 90 | PDPK1 | 0.48767835 |
| 91 | MAP2K2 | 0.48662188 |
| 92 | CDK7 | 0.48420077 |
| 93 | MAP3K1 | 0.48272901 |
| 94 | EPHA2 | 0.48138572 |
| 95 | MAP3K8 | 0.47878274 |
| 96 | ATR | 0.47563973 |
| 97 | CDK4 | 0.46280829 |
| 98 | DAPK1 | 0.45876576 |
| 99 | CDK11A | 0.45452680 |
| 100 | ZAK | 0.44937774 |
| 101 | RPS6KA4 | 0.44349792 |
| 102 | ACVR1B | 0.43509772 |
| 103 | NEK9 | 0.42306358 |
| 104 | STK10 | 0.42098463 |
| 105 | CDC7 | 0.40381354 |
| 106 | PRKG2 | 0.40279182 |
| 107 | CAMK2B | 0.40055708 |
| 108 | LRRK2 | 0.39201137 |
| 109 | STK4 | 0.36939940 |
| 110 | PIK3CG | 0.36707026 |
| 111 | BRSK1 | 0.36638014 |
| 112 | CSNK1G1 | 0.36500947 |
| 113 | CDK15 | 0.35939455 |
| 114 | CAMK2D | 0.35203020 |
| 115 | CDK14 | 0.34305872 |
| 116 | CHEK1 | 0.34226623 |
| 117 | ADRBK1 | 0.34182942 |
| 118 | MST1R | 0.33833820 |
| 119 | MAP2K7 | 0.33810925 |
| 120 | CSNK1A1L | 0.33564287 |
| 121 | EIF2AK2 | 0.32106647 |
| 122 | SYK | 0.32041702 |
| 123 | MAPK11 | 0.31502082 |
| 124 | TYK2 | 0.31328803 |
| 125 | TBK1 | 0.31231085 |
| 126 | CDK18 | 0.30833018 |
| 127 | MUSK | 0.30625269 |
| 128 | CDK8 | 0.30519572 |
| 129 | TTK | 0.30316138 |
| 130 | PLK3 | 0.29952904 |
| 131 | EEF2K | 0.29925610 |
| 132 | PASK | 0.29902205 |
| 133 | PHKG2 | 0.29547719 |
| 134 | PHKG1 | 0.29547719 |
| 135 | LMTK2 | 0.29457800 |
| 136 | IKBKB | 0.28118422 |
| 137 | CDK9 | 0.27673807 |
| 138 | RPS6KL1 | 0.25091068 |
| 139 | RPS6KC1 | 0.25091068 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.61721677 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.41179708 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 4.31219395 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 4.02285655 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.04638741 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 2.82888272 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.71075202 |
| 8 | Protein export_Homo sapiens_hsa03060 | 2.57393642 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.51404510 |
| 10 | DNA replication_Homo sapiens_hsa03030 | 2.20089020 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.98744959 |
| 12 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.82082471 |
| 13 | Mismatch repair_Homo sapiens_hsa03430 | 1.77215785 |
| 14 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.72628737 |
| 15 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.69642114 |
| 16 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.66688376 |
| 17 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.66499503 |
| 18 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.64728984 |
| 19 | Sulfur relay system_Homo sapiens_hsa04122 | 1.61753010 |
| 20 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.48589786 |
| 21 | Spliceosome_Homo sapiens_hsa03040 | 1.46009255 |
| 22 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.40013298 |
| 23 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.39890113 |
| 24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.39827155 |
| 25 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.38433367 |
| 26 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.36825453 |
| 27 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.35768965 |
| 28 | Carbon metabolism_Homo sapiens_hsa01200 | 1.34761388 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.34084156 |
| 30 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.34040038 |
| 31 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.31627466 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.23954877 |
| 33 | Homologous recombination_Homo sapiens_hsa03440 | 1.22321202 |
| 34 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.20952987 |
| 35 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.20951813 |
| 36 | Base excision repair_Homo sapiens_hsa03410 | 1.20602690 |
| 37 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.12368684 |
| 38 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.12076897 |
| 39 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.08373432 |
| 40 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.08101170 |
| 41 | RNA transport_Homo sapiens_hsa03013 | 1.07584799 |
| 42 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.04471888 |
| 43 | Peroxisome_Homo sapiens_hsa04146 | 1.03961205 |
| 44 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.03603913 |
| 45 | Purine metabolism_Homo sapiens_hsa00230 | 1.03138167 |
| 46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.00464149 |
| 47 | Metabolic pathways_Homo sapiens_hsa01100 | 1.00421327 |
| 48 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.97916851 |
| 49 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.96288713 |
| 50 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.92381071 |
| 51 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.88598239 |
| 52 | Basal transcription factors_Homo sapiens_hsa03022 | 0.84395241 |
| 53 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.83733841 |
| 54 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.83708497 |
| 55 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.82737513 |
| 56 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.79597689 |
| 57 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.79503724 |
| 58 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.76481294 |
| 59 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.76169241 |
| 60 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.76027237 |
| 61 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.75484990 |
| 62 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.74792498 |
| 63 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.67079628 |
| 64 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.66811333 |
| 65 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.65624303 |
| 66 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.65293530 |
| 67 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.64932829 |
| 68 | RNA degradation_Homo sapiens_hsa03018 | 0.63452510 |
| 69 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.63349542 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60451990 |
| 71 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.58518538 |
| 72 | Histidine metabolism_Homo sapiens_hsa00340 | 0.57973592 |
| 73 | Bladder cancer_Homo sapiens_hsa05219 | 0.57611951 |
| 74 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.56794663 |
| 75 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.54661915 |
| 76 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.54427721 |
| 77 | Shigellosis_Homo sapiens_hsa05131 | 0.53319738 |
| 78 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.53045644 |
| 79 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.50736375 |
| 80 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.50708034 |
| 81 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.50237495 |
| 82 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.44633382 |
| 83 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.44591123 |
| 84 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.42318272 |
| 85 | Galactose metabolism_Homo sapiens_hsa00052 | 0.42002606 |
| 86 | Prion diseases_Homo sapiens_hsa05020 | 0.39551949 |
| 87 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.39344568 |
| 88 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.38944870 |
| 89 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.38657455 |
| 90 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.37555179 |
| 91 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.37483190 |
| 92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.36339443 |
| 93 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.36237481 |
| 94 | Lysosome_Homo sapiens_hsa04142 | 0.33757277 |
| 95 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.32457772 |
| 96 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.31680846 |
| 97 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.29672607 |
| 98 | Salmonella infection_Homo sapiens_hsa05132 | 0.27888858 |
| 99 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.27259087 |
| 100 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.27173674 |
| 101 | Apoptosis_Homo sapiens_hsa04210 | 0.27120039 |
| 102 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.26999739 |
| 103 | Other glycan degradation_Homo sapiens_hsa00511 | 0.26957451 |
| 104 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.26769276 |
| 105 | Cell cycle_Homo sapiens_hsa04110 | 0.26199725 |
| 106 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.23288615 |
| 107 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.22020150 |
| 108 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.21492766 |
| 109 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.21415650 |
| 110 | HTLV-I infection_Homo sapiens_hsa05166 | 0.21008096 |
| 111 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.20927919 |
| 112 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.20797372 |
| 113 | Retinol metabolism_Homo sapiens_hsa00830 | 0.19926337 |
| 114 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.19921434 |
| 115 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.19833395 |
| 116 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.18196897 |
| 117 | Asthma_Homo sapiens_hsa05310 | 0.17261237 |
| 118 | Alcoholism_Homo sapiens_hsa05034 | 0.15723217 |
| 119 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.14497334 |
| 120 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.14406619 |
| 121 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.14396960 |
| 122 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.12972361 |
| 123 | Viral myocarditis_Homo sapiens_hsa05416 | 0.11992809 |
| 124 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.10557760 |
| 125 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.08732036 |
| 126 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.07331832 |
| 127 | Thyroid cancer_Homo sapiens_hsa05216 | 0.06908605 |
| 128 | Endocytosis_Homo sapiens_hsa04144 | 0.05593205 |

