AURKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protein localization to kinetochore (GO:0034501)5.44519958
2DNA unwinding involved in DNA replication (GO:0006268)5.44411459
3DNA strand elongation involved in DNA replication (GO:0006271)5.38240727
4telomere maintenance via semi-conservative replication (GO:0032201)5.19729847
5mitotic sister chromatid segregation (GO:0000070)5.13107854
6DNA strand elongation (GO:0022616)5.12224488
7mitotic metaphase plate congression (GO:0007080)4.92889582
8mitotic chromosome condensation (GO:0007076)4.91113365
9sister chromatid segregation (GO:0000819)4.85682036
10kinetochore organization (GO:0051383)4.84744809
11* protein localization to chromosome, centromeric region (GO:0071459)4.79037504
12DNA replication initiation (GO:0006270)4.75557684
13CENP-A containing nucleosome assembly (GO:0034080)4.69082118
14telomere maintenance via recombination (GO:0000722)4.68039066
15mitotic recombination (GO:0006312)4.67393898
16chromatin remodeling at centromere (GO:0031055)4.52827038
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.51688715
18establishment of integrated proviral latency (GO:0075713)4.49720928
19metaphase plate congression (GO:0051310)4.38051047
20DNA replication checkpoint (GO:0000076)4.36640342
21DNA replication-independent nucleosome organization (GO:0034724)4.27613513
22DNA replication-independent nucleosome assembly (GO:0006336)4.27613513
23mitotic nuclear envelope disassembly (GO:0007077)4.22333947
24establishment of chromosome localization (GO:0051303)4.19992812
25kinetochore assembly (GO:0051382)4.17676027
26* attachment of spindle microtubules to kinetochore (GO:0008608)4.13768826
27telomere maintenance via telomere lengthening (GO:0010833)4.10300689
28DNA replication-dependent nucleosome organization (GO:0034723)4.09249114
29DNA replication-dependent nucleosome assembly (GO:0006335)4.09249114
30nucleotide-excision repair, DNA gap filling (GO:0006297)4.01501462
31meiotic chromosome segregation (GO:0045132)4.00442144
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.97511648
33nuclear envelope disassembly (GO:0051081)3.89864536
34membrane disassembly (GO:0030397)3.89864536
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.84173709
36histone exchange (GO:0043486)3.84139231
37positive regulation of chromosome segregation (GO:0051984)3.76834050
38* regulation of spindle organization (GO:0090224)3.75134727
39ribosomal small subunit assembly (GO:0000028)3.73548555
40* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68351829
41nucleobase biosynthetic process (GO:0046112)3.66139676
42nuclear pore organization (GO:0006999)3.64494451
43chromosome segregation (GO:0007059)3.63875588
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59664296
45formation of translation preinitiation complex (GO:0001731)3.58389349
46DNA topological change (GO:0006265)3.57968699
47regulation of mitotic spindle organization (GO:0060236)3.54452982
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54320775
49negative regulation of mitosis (GO:0045839)3.53893832
50* regulation of chromosome segregation (GO:0051983)3.53743896
51establishment of viral latency (GO:0019043)3.53286648
52negative regulation of chromosome segregation (GO:0051985)3.52522400
53spindle assembly checkpoint (GO:0071173)3.51306006
54* protein localization to chromosome (GO:0034502)3.50740002
55* spindle checkpoint (GO:0031577)3.50565217
56microtubule depolymerization (GO:0007019)3.49944510
57nuclear pore complex assembly (GO:0051292)3.48038908
58negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46998800
59negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46998800
60negative regulation of sister chromatid segregation (GO:0033046)3.46998800
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.46998800
62DNA duplex unwinding (GO:0032508)3.43476558
63DNA geometric change (GO:0032392)3.42952848
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.42484903
65chromatin assembly or disassembly (GO:0006333)3.42472487
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.41516734
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.41516734
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.41516734
69DNA deamination (GO:0045006)3.39812777
70mitotic spindle assembly checkpoint (GO:0007094)3.38090623
71IMP biosynthetic process (GO:0006188)3.37514147
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36991560
73chromosome condensation (GO:0030261)3.35883645
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.34854624
75folic acid-containing compound biosynthetic process (GO:0009396)3.33028293
76purine nucleobase biosynthetic process (GO:0009113)3.28974285
77mitotic spindle checkpoint (GO:0071174)3.27307802
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27077170
79negative regulation of ligase activity (GO:0051352)3.27077170
80regulation of mitotic sister chromatid separation (GO:0010965)3.25812537
81regulation of mitotic sister chromatid segregation (GO:0033047)3.25812537
82regulation of sister chromatid segregation (GO:0033045)3.25812537
83protein K6-linked ubiquitination (GO:0085020)3.24802376
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24476414
85regulation of centrosome cycle (GO:0046605)3.24158273
86heterochromatin organization (GO:0070828)3.23686250
87regulation of sister chromatid cohesion (GO:0007063)3.21926024
88ATP-dependent chromatin remodeling (GO:0043044)3.20764252
89maturation of SSU-rRNA (GO:0030490)3.20721731
90protein complex localization (GO:0031503)3.19145813
91DNA conformation change (GO:0071103)3.17596129
92telomere maintenance (GO:0000723)3.17099609
93mitotic sister chromatid cohesion (GO:0007064)3.16126057
94telomere organization (GO:0032200)3.15722267
95translesion synthesis (GO:0019985)3.14555640
96regulation of double-strand break repair via homologous recombination (GO:0010569)3.14005449
97viral transcription (GO:0019083)3.13405080
98somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13388581
99somatic hypermutation of immunoglobulin genes (GO:0016446)3.13388581
100* mitotic cell cycle (GO:0000278)3.12503537
101L-serine metabolic process (GO:0006563)3.11047562
102proteasome assembly (GO:0043248)3.10806300
103translational termination (GO:0006415)3.10745671
104negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.10232772
105base-excision repair (GO:0006284)3.09874556
106nuclear envelope organization (GO:0006998)3.07394793
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07239079
108ventricular cardiac muscle cell development (GO:0055015)3.06516678
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06360710
110DNA packaging (GO:0006323)3.01477038
111mismatch repair (GO:0006298)3.01234498
112IMP metabolic process (GO:0046040)3.01120191
113DNA strand renaturation (GO:0000733)2.99836812
114negative regulation of nuclear division (GO:0051784)2.99497252
115spliceosomal snRNP assembly (GO:0000387)2.97779809
116postreplication repair (GO:0006301)2.96746427
117double-strand break repair via nonhomologous end joining (GO:0006303)2.95869084
118non-recombinational repair (GO:0000726)2.95869084
119DNA ligation (GO:0006266)2.95727807
120regulation of spindle checkpoint (GO:0090231)2.95480404
121ribosomal small subunit biogenesis (GO:0042274)2.94205979
122negative regulation of RNA splicing (GO:0033119)2.93337888
123cell cycle G1/S phase transition (GO:0044843)2.88757095
124G1/S transition of mitotic cell cycle (GO:0000082)2.88757095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.89506388
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.12622382
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37442020
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.94532820
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.76500606
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62052468
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79723095
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65036188
9AR_21909140_ChIP-Seq_LNCAP_Human2.63619521
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54672282
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50960974
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.50702015
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33102880
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.27615832
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.25365965
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24603716
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22995182
18* E2F1_21310950_ChIP-Seq_MCF-7_Human2.22929486
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.20048454
20XRN2_22483619_ChIP-Seq_HELA_Human2.19517736
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18648681
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18285375
23* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98356960
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94032854
25VDR_23849224_ChIP-Seq_CD4+_Human1.93660677
26MYC_22102868_ChIP-Seq_BL_Human1.93422992
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85390939
28FOXP3_21729870_ChIP-Seq_TREG_Human1.83841922
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82342388
30DCP1A_22483619_ChIP-Seq_HELA_Human1.78991155
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77783545
32CIITA_25753668_ChIP-Seq_RAJI_Human1.75023364
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73881560
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71482242
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69621549
36TTF2_22483619_ChIP-Seq_HELA_Human1.65353591
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63976445
38GABP_19822575_ChIP-Seq_HepG2_Human1.63050639
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59637197
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57963179
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57365524
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56394017
43* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53313846
44VDR_21846776_ChIP-Seq_THP-1_Human1.48309222
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48270272
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44593637
47ELK1_19687146_ChIP-ChIP_HELA_Human1.43174579
48KDM5A_27292631_Chip-Seq_BREAST_Human1.41903405
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39427590
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39393876
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37826583
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35780679
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35300267
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33310948
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.27765838
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26728912
57* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26020661
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25402764
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23844228
60* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20131609
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15498204
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15311087
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.15116483
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11233513
65TFEB_21752829_ChIP-Seq_HELA_Human1.07056537
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06924559
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05824047
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05090420
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05005439
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.04959846
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03869269
72SPI1_23547873_ChIP-Seq_NB4_Human1.03684676
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.03410994
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02647513
75NANOG_16153702_ChIP-ChIP_HESCs_Human0.98565207
76* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96984056
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96840854
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94417312
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93606291
80* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93548005
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93457479
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91128911
83* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90950338
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90506929
85* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90093975
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89779839
87* SOX17_20123909_ChIP-Seq_XEN_Mouse0.89365665
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89326837
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88612171
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87972567
91MYC_18940864_ChIP-ChIP_HL60_Human0.86973099
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85332285
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81915108
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81881396
95MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80429243
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79787506
97NANOG_21062744_ChIP-ChIP_HESCs_Human0.79523250
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78162805
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77389341
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77097498
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76857186
102UTX_26944678_Chip-Seq_JUKART_Human0.76667940
103MAF_26560356_Chip-Seq_TH1_Human0.75956424
104* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75308550
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75041487
106MYB_26560356_Chip-Seq_TH2_Human0.74499798
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74096053
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74084351
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74005097
110* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72976034
111* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71560839
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71444005
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70320460
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69855019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.75526021
2MP0010094_abnormal_chromosome_stability5.05472894
3MP0003111_abnormal_nucleus_morphology4.93118601
4MP0008057_abnormal_DNA_replication4.34893141
5MP0003077_abnormal_cell_cycle4.34717119
6MP0004957_abnormal_blastocyst_morpholog4.33503848
7MP0008058_abnormal_DNA_repair3.06487498
8MP0002396_abnormal_hematopoietic_system2.89896180
9MP0008007_abnormal_cellular_replicative2.87591453
10MP0008932_abnormal_embryonic_tissue2.52023465
11MP0001730_embryonic_growth_arrest2.33635764
12MP0000350_abnormal_cell_proliferation2.31513568
13MP0010307_abnormal_tumor_latency2.13784844
14MP0006292_abnormal_olfactory_placode2.09972123
15MP0010352_gastrointestinal_tract_polyps2.03884398
16MP0003123_paternal_imprinting1.97743973
17MP0000490_abnormal_crypts_of1.95100034
18MP0004808_abnormal_hematopoietic_stem1.86080556
19MP0009697_abnormal_copulation1.83213693
20MP0008877_abnormal_DNA_methylation1.77067654
21MP0001697_abnormal_embryo_size1.73197582
22MP0001672_abnormal_embryogenesis/_devel1.72174866
23MP0005380_embryogenesis_phenotype1.72174866
24MP0003786_premature_aging1.65192083
25MP0002080_prenatal_lethality1.60735495
26MP0002019_abnormal_tumor_incidence1.60405137
27MP0003984_embryonic_growth_retardation1.54739603
28MP0001545_abnormal_hematopoietic_system1.53832557
29MP0005397_hematopoietic_system_phenotyp1.53832557
30MP0000313_abnormal_cell_death1.52932292
31MP0005076_abnormal_cell_differentiation1.52179685
32MP0002088_abnormal_embryonic_growth/wei1.50267288
33MP0002085_abnormal_embryonic_tissue1.46267978
34MP0006054_spinal_hemorrhage1.45674420
35MP0002086_abnormal_extraembryonic_tissu1.40283978
36MP0002398_abnormal_bone_marrow1.38740220
37MP0006035_abnormal_mitochondrial_morpho1.38312170
38MP0003941_abnormal_skin_development1.37840535
39MP0002938_white_spotting1.37597883
40MP0001346_abnormal_lacrimal_gland1.36300337
41MP0009333_abnormal_splenocyte_physiolog1.35427432
42MP0000703_abnormal_thymus_morphology1.34499478
43MP0004197_abnormal_fetal_growth/weight/1.32993370
44MP0002084_abnormal_developmental_patter1.29995133
45MP0003567_abnormal_fetal_cardiomyocyte1.27156971
46MP0002722_abnormal_immune_system1.26985252
47MP0003763_abnormal_thymus_physiology1.26590551
48MP0009278_abnormal_bone_marrow1.23531389
49MP0009379_abnormal_foot_pigmentation1.22560584
50MP0000689_abnormal_spleen_morphology1.20179945
51MP0002697_abnormal_eye_size1.18928059
52MP0003121_genomic_imprinting1.18225040
53MP0003718_maternal_effect1.10602408
54MP0002163_abnormal_gland_morphology1.06252220
55MP0002429_abnormal_blood_cell1.06064762
56MP0006036_abnormal_mitochondrial_physio1.05137805
57MP0010030_abnormal_orbit_morphology1.03998420
58MP0001286_abnormal_eye_development1.03781961
59MP0000566_synostosis1.01061456
60MP0000049_abnormal_middle_ear1.00030463
61MP0002210_abnormal_sex_determination0.98714025
62MP0003136_yellow_coat_color0.98023635
63MP0001293_anophthalmia0.97665008
64MP0000858_altered_metastatic_potential0.97138987
65MP0000716_abnormal_immune_system0.94021400
66MP0001529_abnormal_vocalization0.91515351
67MP0001145_abnormal_male_reproductive0.89286901
68MP0008789_abnormal_olfactory_epithelium0.87658937
69MP0003890_abnormal_embryonic-extraembry0.86753395
70MP0009672_abnormal_birth_weight0.86506363
71MP0002234_abnormal_pharynx_morphology0.85913099
72MP0003656_abnormal_erythrocyte_physiolo0.85284332
73MP0001800_abnormal_humoral_immune0.84277143
74MP0004147_increased_porphyrin_level0.84084803
75MP0005501_abnormal_skin_physiology0.82691359
76MP0002233_abnormal_nose_morphology0.82688616
77MP0001835_abnormal_antigen_presentation0.82075180
78MP0003705_abnormal_hypodermis_morpholog0.81460111
79MP0009053_abnormal_anal_canal0.79990153
80MP0003315_abnormal_perineum_morphology0.79318907
81MP0003861_abnormal_nervous_system0.79065333
82MP0002420_abnormal_adaptive_immunity0.78784759
83MP0000537_abnormal_urethra_morphology0.78614151
84MP0005023_abnormal_wound_healing0.78463547
85MP0000372_irregular_coat_pigmentation0.78190739
86MP0005621_abnormal_cell_physiology0.77636415
87MP0001819_abnormal_immune_cell0.77401740
88MP0005384_cellular_phenotype0.76898266
89MP0000685_abnormal_immune_system0.76427225
90MP0001929_abnormal_gametogenesis0.75833564
91MP0001915_intracranial_hemorrhage0.75761202
92MP0002132_abnormal_respiratory_system0.75740964
93MP0002452_abnormal_antigen_presenting0.74911761
94MP0002111_abnormal_tail_morphology0.73975014
95MP0002405_respiratory_system_inflammati0.73396430
96MP0001853_heart_inflammation0.73063804
97MP0000653_abnormal_sex_gland0.71868863
98MP0001661_extended_life_span0.68591585
99MP0000358_abnormal_cell_content/0.68501497
100MP0005394_taste/olfaction_phenotype0.67869297
101MP0005499_abnormal_olfactory_system0.67869297
102MP0000477_abnormal_intestine_morphology0.67597921
103MP0003566_abnormal_cell_adhesion0.67131069
104MP0001119_abnormal_female_reproductive0.67094685
105MP0003755_abnormal_palate_morphology0.66827335
106MP0002161_abnormal_fertility/fecundity0.66543374
107MP0002095_abnormal_skin_pigmentation0.65487540
108MP0004233_abnormal_muscle_weight0.65091587
109MP0009703_decreased_birth_body0.64682156
110MP0003699_abnormal_female_reproductive0.64609357
111MP0002877_abnormal_melanocyte_morpholog0.64069541
112MP0002160_abnormal_reproductive_system0.62804024
113MP0004264_abnormal_extraembryonic_tissu0.62658745
114MP0001849_ear_inflammation0.61668015
115MP0003806_abnormal_nucleotide_metabolis0.61157834
116MP0003698_abnormal_male_reproductive0.60167468
117MP0005395_other_phenotype0.60129852
118MP0000465_gastrointestinal_hemorrhage0.59988726
119MP0003942_abnormal_urinary_system0.59973330
120MP0002723_abnormal_immune_serum0.58998221
121MP0008995_early_reproductive_senescence0.58765814
122MP0005623_abnormal_meninges_morphology0.57697356
123MP0006072_abnormal_retinal_apoptosis0.57399327
124MP0003943_abnormal_hepatobiliary_system0.57186309
125MP0003938_abnormal_ear_development0.57164099
126MP0003935_abnormal_craniofacial_develop0.57015916
127MP0003436_decreased_susceptibility_to0.56840216
128MP0003448_altered_tumor_morphology0.56378056
129MP0002092_abnormal_eye_morphology0.55989094
130MP0004185_abnormal_adipocyte_glucose0.55891287
131MP0000428_abnormal_craniofacial_morphol0.55808779
132MP0003186_abnormal_redox_activity0.55464101
133MP0001727_abnormal_embryo_implantation0.55235892
134MP0003119_abnormal_digestive_system0.54241380
135MP0005174_abnormal_tail_pigmentation0.53712953
136MP0010155_abnormal_intestine_physiology0.53647580
137MP0005671_abnormal_response_to0.53520131
138MP0003937_abnormal_limbs/digits/tail_de0.53408439
139MP0002114_abnormal_axial_skeleton0.52583927
140MP0001881_abnormal_mammary_gland0.51927758
141MP0002006_tumorigenesis0.51799381
142MP0000647_abnormal_sebaceous_gland0.51330546
143MP0009250_abnormal_appendicular_skeleto0.51092152

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.50084037
2Chromsome breakage (HP:0040012)4.33715969
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.15121617
4Reticulocytopenia (HP:0001896)4.08065553
5Abnormality of cells of the erythroid lineage (HP:0012130)3.59820282
6Colon cancer (HP:0003003)3.56160063
7Abnormal number of erythroid precursors (HP:0012131)3.53556221
8Breast hypoplasia (HP:0003187)3.52705380
9Patellar aplasia (HP:0006443)3.38506630
10Abnormality of chromosome stability (HP:0003220)3.36673720
11Meckel diverticulum (HP:0002245)3.32204163
12Selective tooth agenesis (HP:0001592)3.30938472
13Abnormality of the ileum (HP:0001549)3.18924718
14Abnormality of the preputium (HP:0100587)3.16047846
15Oral leukoplakia (HP:0002745)3.13681541
16Aplasia/Hypoplasia of the patella (HP:0006498)3.13570844
17Small intestinal stenosis (HP:0012848)3.07019406
18Duodenal stenosis (HP:0100867)3.07019406
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.01196616
20Myelodysplasia (HP:0002863)2.97455345
21Carpal bone hypoplasia (HP:0001498)2.96854222
22Increased nuchal translucency (HP:0010880)2.94253870
23Medulloblastoma (HP:0002885)2.91582644
24Agnosia (HP:0010524)2.91027483
25Ependymoma (HP:0002888)2.84142072
26Impulsivity (HP:0100710)2.82379750
27Abnormal lung lobation (HP:0002101)2.81960860
28Cortical dysplasia (HP:0002539)2.79181438
29Microvesicular hepatic steatosis (HP:0001414)2.73185834
30Abnormality of the anterior horn cell (HP:0006802)2.71438976
31Degeneration of anterior horn cells (HP:0002398)2.71438976
32Aplastic anemia (HP:0001915)2.69066699
33Absent thumb (HP:0009777)2.56472723
3411 pairs of ribs (HP:0000878)2.55024532
35Bone marrow hypocellularity (HP:0005528)2.54795989
36Acute necrotizing encephalopathy (HP:0006965)2.54603019
37Hypoplasia of the capital femoral epiphysis (HP:0003090)2.52686593
38Abnormal mitochondria in muscle tissue (HP:0008316)2.49819911
39Abnormality of the duodenum (HP:0002246)2.48841045
40Sloping forehead (HP:0000340)2.46073864
41Broad distal phalanx of finger (HP:0009836)2.45695335
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43014314
43Short 4th metacarpal (HP:0010044)2.43014314
44High pitched voice (HP:0001620)2.41515155
45Rough bone trabeculation (HP:0100670)2.41435456
46Ectopic kidney (HP:0000086)2.39272960
47Acute encephalopathy (HP:0006846)2.38618587
48Absent radius (HP:0003974)2.38556127
49Neoplasm of the pancreas (HP:0002894)2.37945176
50Abnormality of glycolysis (HP:0004366)2.37902129
51Basal cell carcinoma (HP:0002671)2.37798382
52Volvulus (HP:0002580)2.36333103
53Abnormal number of incisors (HP:0011064)2.36296081
54Rhabdomyosarcoma (HP:0002859)2.35170226
55Thrombocytosis (HP:0001894)2.34315285
56Pallor (HP:0000980)2.32820243
57Microretrognathia (HP:0000308)2.32516788
58Tracheoesophageal fistula (HP:0002575)2.31755188
59Proximal placement of thumb (HP:0009623)2.27413244
60Nephroblastoma (Wilms tumor) (HP:0002667)2.26753993
61Cafe-au-lait spot (HP:0000957)2.25987169
62Atresia of the external auditory canal (HP:0000413)2.25388556
63Premature graying of hair (HP:0002216)2.25376005
64Abnormality of the carotid arteries (HP:0005344)2.23981580
65Hypoplastic pelvis (HP:0008839)2.21391253
66Absent forearm bone (HP:0003953)2.19750884
67Aplasia involving forearm bones (HP:0009822)2.19750884
68Duplicated collecting system (HP:0000081)2.19271425
69Deviation of the thumb (HP:0009603)2.18764206
70Increased serum pyruvate (HP:0003542)2.18245663
71Embryonal neoplasm (HP:0002898)2.16183327
72Macrocytic anemia (HP:0001972)2.15239540
73Cellular immunodeficiency (HP:0005374)2.15201581
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.14989365
75Mitochondrial inheritance (HP:0001427)2.14117610
76Increased CSF lactate (HP:0002490)2.12090304
77Lymphoma (HP:0002665)2.11409768
78IgM deficiency (HP:0002850)2.11275803
79Clubbing of toes (HP:0100760)2.10101514
80Embryonal renal neoplasm (HP:0011794)2.09872416
81Duplication of thumb phalanx (HP:0009942)2.09233894
82Hepatocellular necrosis (HP:0001404)2.08781842
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07612448
84Prominent nose (HP:0000448)2.07105172
85Abnormality of cochlea (HP:0000375)2.06054478
86Progressive muscle weakness (HP:0003323)2.06020445
87Facial cleft (HP:0002006)2.05155168
88Neoplasm of the colon (HP:0100273)2.02949961
89Abnormality of reticulocytes (HP:0004312)2.00926605
90Horseshoe kidney (HP:0000085)1.99801417
91High anterior hairline (HP:0009890)1.98232562
92Increased hepatocellular lipid droplets (HP:0006565)1.98179124
93Choanal atresia (HP:0000453)1.96650255
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96390199
95Type I transferrin isoform profile (HP:0003642)1.96252789
96Slender long bone (HP:0003100)1.95004106
97Squamous cell carcinoma (HP:0002860)1.94946129
98Pancytopenia (HP:0001876)1.94823504
99Multiple enchondromatosis (HP:0005701)1.94789399
100Short thumb (HP:0009778)1.94788321
101Abnormality of the labia minora (HP:0012880)1.93823917
102Facial hemangioma (HP:0000329)1.93046181
103Abnormality of the calcaneus (HP:0008364)1.92823209
104Cleft eyelid (HP:0000625)1.92493603
105Single umbilical artery (HP:0001195)1.92131699
106Abnormality of the fetal cardiovascular system (HP:0010948)1.92131699
107Abnormal umbilical cord blood vessels (HP:0011403)1.92131699
108Abnormality of the renal collecting system (HP:0004742)1.91851822
109Trismus (HP:0000211)1.90577047
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.89305693
111Abnormality of the umbilical cord (HP:0010881)1.88874441
112Triphalangeal thumb (HP:0001199)1.88026265
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85345018
114Absent epiphyses (HP:0010577)1.85345018
115Cerebral edema (HP:0002181)1.84845256
116Arteriovenous malformation (HP:0100026)1.82682065
117Increased serum lactate (HP:0002151)1.82550894
118Irregular epiphyses (HP:0010582)1.82436999
119Progressive macrocephaly (HP:0004481)1.81235751
120Amaurosis fugax (HP:0100576)1.79153487
121Lipid accumulation in hepatocytes (HP:0006561)1.78829530
122Cellulitis (HP:0100658)1.78463853
123Hepatic necrosis (HP:0002605)1.77326056
124Missing ribs (HP:0000921)1.75893909
125Ovarian neoplasm (HP:0100615)1.74284779
126Neoplasm of striated muscle (HP:0009728)1.72361338
127Abnormality of the astrocytes (HP:0100707)1.71870965
128Astrocytoma (HP:0009592)1.71870965
129Poikiloderma (HP:0001029)1.71453784
130Abnormality of DNA repair (HP:0003254)1.70309465
131Reduced antithrombin III activity (HP:0001976)1.67914539
132Overlapping toe (HP:0001845)1.67539459
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.66133708
134Abnormal trabecular bone morphology (HP:0100671)1.65657013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.46757234
2CDC74.51505219
3WEE14.39801351
4VRK23.72877963
5NEK23.60978485
6NEK12.77185052
7BRSK22.71508661
8TTK2.54746705
9EIF2AK12.33413308
10PLK12.18996398
11CCNB12.03141488
12ACVR1B2.02663338
13TAF11.97864177
14BRSK11.96812778
15PLK41.94840181
16SMG11.92913719
17TESK21.91954156
18SRPK11.88290073
19* AURKB1.84925680
20STK101.84576349
21MAP3K101.81219672
22EEF2K1.72805224
23CDK71.67281430
24ATR1.65486020
25CHEK21.56160290
26CDK41.55086732
27VRK11.54754987
28RPS6KA41.54408758
29MAP3K81.51402723
30CDK121.51292462
31NME21.49339116
32TSSK61.49041238
33PLK31.48144578
34PASK1.46394743
35MKNK11.43892917
36MAP4K11.34722515
37AURKA1.33630432
38TLK11.32592494
39RPS6KB21.31413641
40STK161.29977064
41EIF2AK31.25701089
42DYRK31.22479536
43NME11.14830706
44* CHEK11.13172910
45PAK41.12709920
46SCYL21.08431040
47CLK11.08265199
48NUAK11.00358941
49CDK60.97976625
50TGFBR10.97865661
51PKN20.90078632
52PIM10.88372144
53FLT30.86606562
54LRRK20.85493546
55ATM0.82873738
56CDK20.81763220
57MELK0.81630837
58KDR0.78989465
59MKNK20.78424876
60MST40.76919991
61* STK40.76193541
62BLK0.75786865
63BTK0.67437806
64ZAK0.67030281
65CDK10.66872770
66PAK10.64147702
67PIM20.62873121
68CDK80.62702593
69GRK60.62100305
70TESK10.62032069
71EIF2AK20.61953349
72TRIM280.61313046
73BRD40.57688450
74BCKDK0.55711730
75CSF1R0.55272896
76PDK20.54950291
77CSNK2A10.54820881
78STK30.53625624
79MAP2K30.53358010
80CSNK2A20.49857724
81CDK90.46033375
82CSNK1G30.44494742
83ALK0.44261659
84MAP3K110.43866999
85BRAF0.42057061
86ZAP700.41268486
87RPS6KA50.41160220
88TRIB30.40410477
89CSNK1G10.39706655
90DYRK20.39157054
91PRKCI0.39054411
92IRAK40.38766441
93PBK0.38757634
94DAPK10.38369972
95AKT20.38093803
96CDK140.37327128
97MARK30.36083857
98TEC0.35386971
99NEK90.34515479
100EPHA20.33684937
101CSNK1A1L0.32488912
102MAPK110.31597522
103PNCK0.31412760
104UHMK10.30860296
105TNIK0.30578328
106LYN0.30468368
107KIT0.29561131
108MTOR0.28978576
109MAPKAPK20.28911651
110CDK11A0.27619441
111ERBB40.27615852
112CDK30.26887775
113PRKDC0.25860425
114ILK0.25357527
115CSNK1E0.25117581
116CDK150.24906618
117JAK30.23736229
118CDK180.23365790
119MST1R0.23103773
120RPS6KL10.22694319
121RPS6KC10.22694319
122RPS6KA60.21609887
123MAPKAPK50.19567374
124CSNK1G20.18328050
125DAPK30.17187397
126FGFR10.16123979
127PLK20.15190717
128IRAK30.14258838
129LATS20.13657968
130MAPK140.13002835

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.69333188
2Mismatch repair_Homo sapiens_hsa034304.74935514
3Base excision repair_Homo sapiens_hsa034103.65132459
4Homologous recombination_Homo sapiens_hsa034403.34093039
5Cell cycle_Homo sapiens_hsa041103.26587863
6Spliceosome_Homo sapiens_hsa030403.19582532
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94170384
8Nucleotide excision repair_Homo sapiens_hsa034202.93622718
9RNA transport_Homo sapiens_hsa030132.87916345
10Ribosome_Homo sapiens_hsa030102.86883306
11Proteasome_Homo sapiens_hsa030502.54155083
12One carbon pool by folate_Homo sapiens_hsa006702.52592768
13Fanconi anemia pathway_Homo sapiens_hsa034602.49447333
14RNA polymerase_Homo sapiens_hsa030202.33323828
15Non-homologous end-joining_Homo sapiens_hsa034502.26005475
16Pyrimidine metabolism_Homo sapiens_hsa002402.25502729
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12376104
18RNA degradation_Homo sapiens_hsa030181.78253502
19p53 signaling pathway_Homo sapiens_hsa041151.76851329
20mRNA surveillance pathway_Homo sapiens_hsa030151.68533822
21Parkinsons disease_Homo sapiens_hsa050121.61101769
22Oxidative phosphorylation_Homo sapiens_hsa001901.54580702
23Basal transcription factors_Homo sapiens_hsa030221.54465063
24Systemic lupus erythematosus_Homo sapiens_hsa053221.47989748
25Huntingtons disease_Homo sapiens_hsa050161.38932316
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30920603
27Oocyte meiosis_Homo sapiens_hsa041141.21115296
28Pyruvate metabolism_Homo sapiens_hsa006201.20107239
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17406095
30Epstein-Barr virus infection_Homo sapiens_hsa051691.15250582
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11425607
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10804919
33Viral carcinogenesis_Homo sapiens_hsa052031.10733030
34Purine metabolism_Homo sapiens_hsa002301.08844002
35Herpes simplex infection_Homo sapiens_hsa051681.05689025
36Antigen processing and presentation_Homo sapiens_hsa046120.98128065
37Fatty acid elongation_Homo sapiens_hsa000620.97816195
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93126418
39Primary immunodeficiency_Homo sapiens_hsa053400.92964260
40HTLV-I infection_Homo sapiens_hsa051660.90480130
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87941539
42Alzheimers disease_Homo sapiens_hsa050100.87783355
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85848332
44Pentose phosphate pathway_Homo sapiens_hsa000300.85073443
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84841857
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84242145
47Small cell lung cancer_Homo sapiens_hsa052220.79960892
48Steroid biosynthesis_Homo sapiens_hsa001000.79815725
49MicroRNAs in cancer_Homo sapiens_hsa052060.79568711
50Biosynthesis of amino acids_Homo sapiens_hsa012300.70740986
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69541914
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68691722
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.66482754
54Selenocompound metabolism_Homo sapiens_hsa004500.64151622
55Thyroid cancer_Homo sapiens_hsa052160.63869574
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62263800
57Legionellosis_Homo sapiens_hsa051340.61477309
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.60589638
59Apoptosis_Homo sapiens_hsa042100.60364889
60Propanoate metabolism_Homo sapiens_hsa006400.59833387
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.57315574
62Alcoholism_Homo sapiens_hsa050340.55823032
63Folate biosynthesis_Homo sapiens_hsa007900.55007647
64Chronic myeloid leukemia_Homo sapiens_hsa052200.54532884
65Shigellosis_Homo sapiens_hsa051310.54096328
66Hepatitis B_Homo sapiens_hsa051610.53760299
67Colorectal cancer_Homo sapiens_hsa052100.52375730
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52066516
69Metabolic pathways_Homo sapiens_hsa011000.49611949
70Sulfur relay system_Homo sapiens_hsa041220.49039188
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48667933
72Vitamin B6 metabolism_Homo sapiens_hsa007500.48303040
73N-Glycan biosynthesis_Homo sapiens_hsa005100.48121675
74Measles_Homo sapiens_hsa051620.47990704
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46346215
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46316296
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44563964
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.44082136
79Bladder cancer_Homo sapiens_hsa052190.43774230
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42946972
81Viral myocarditis_Homo sapiens_hsa054160.40938142
82Arginine and proline metabolism_Homo sapiens_hsa003300.39840881
83Glutathione metabolism_Homo sapiens_hsa004800.38522766
84Protein export_Homo sapiens_hsa030600.36183687
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36051044
86Non-small cell lung cancer_Homo sapiens_hsa052230.35740736
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.34957714
88Carbon metabolism_Homo sapiens_hsa012000.34316138
89Hematopoietic cell lineage_Homo sapiens_hsa046400.34127970
90B cell receptor signaling pathway_Homo sapiens_hsa046620.33840609
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33449008
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31798862
93Pancreatic cancer_Homo sapiens_hsa052120.31585973
94Notch signaling pathway_Homo sapiens_hsa043300.30408933
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30108300
96Wnt signaling pathway_Homo sapiens_hsa043100.30007843
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29957205
98Hippo signaling pathway_Homo sapiens_hsa043900.29541948
99Influenza A_Homo sapiens_hsa051640.29290030
100Leishmaniasis_Homo sapiens_hsa051400.29255865
101Hedgehog signaling pathway_Homo sapiens_hsa043400.28725496
102TGF-beta signaling pathway_Homo sapiens_hsa043500.28540745
103Pathways in cancer_Homo sapiens_hsa052000.27560639
104Acute myeloid leukemia_Homo sapiens_hsa052210.27159250
105Cardiac muscle contraction_Homo sapiens_hsa042600.26429395
106Basal cell carcinoma_Homo sapiens_hsa052170.26003448
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.25094339
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23898183
109HIF-1 signaling pathway_Homo sapiens_hsa040660.23460662
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.22866298
111Renin-angiotensin system_Homo sapiens_hsa046140.21511974
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21439999
113Lysine degradation_Homo sapiens_hsa003100.20067096
114Prostate cancer_Homo sapiens_hsa052150.19834907
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19474387
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19080485
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18743889
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18073863
119Fatty acid metabolism_Homo sapiens_hsa012120.18022001
120mTOR signaling pathway_Homo sapiens_hsa041500.17377203
121Adherens junction_Homo sapiens_hsa045200.16785286
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16761246
123Galactose metabolism_Homo sapiens_hsa000520.16137674
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15443548
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15201756
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14690057
127Fructose and mannose metabolism_Homo sapiens_hsa000510.13392822
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10391712
129Melanoma_Homo sapiens_hsa052180.08333437
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07869913
131Tyrosine metabolism_Homo sapiens_hsa003500.07029924
132Phenylalanine metabolism_Homo sapiens_hsa003600.06121373

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